Modulating resistance to bcl-2 inhibitors

ABSTRACT

This invention relates to compositions and methods for identifying the network that modulates, controls, or otherwise influences BCL-2 pathway inhibition, for example, energy-stress signaling, mitochondrial metabolism, vesicle transport, ribosomal components, and proteolysis. The invention also relates to identifying and modulating target genes and/or target gene products that modulate, control, or otherwise influence BCL-2 pathway inhibition.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. Provisional Application No.62/744,081, filed Oct. 10, 2018. The entire contents of theabove-identified application are hereby fully incorporated herein byreference.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH

This invention was made with government support under Grant No. CA206978awarded by the National Institutes of Health. The government has certainrights in the invention.

REFERENCE TO AN ELECTRONIC SEQUENCE LISTING

The contents of the electronic sequence listing (BROD_4430_ST25.txt”;Size is 4,955 bytes and it was created on Oct. 10, 2019) is hereinincorporated by reference in its entirety.

TECHNICAL FIELD

The subject matter disclosed herein is generally directed tocompositions and methods for identifying the network that modulates,controls, or otherwise influences BCL-2 pathway inhibition, for example,energy-stress signaling, mitochondrial metabolism, vesicle transport,ribosomal components, and proteolysis. The invention also relates toidentifying and modulating target genes, target gene products and/ortarget pathways that modulate, control, or otherwise influenceresistance to BCL-2 pathway inhibition.

BACKGROUND

The B-cell lymphoma 2 (BCL-2) family includes both pro- andanti-apoptotic proteins that govern mitochondrial apoptosis. Inleukemias and solid cancers, apoptosis dysregulation can result fromoverexpression of the anti-apoptotic BCL-2 protein that can sequestercertain pro-apoptotic BH3-only proteins (BIM, BID) to avoid BAX and BAKoligomerization and subsequent mitochondrial outer membranepermeabilization. Within B cell tumors, BCL-2 dysregulation commonlyarises from genetic abnormalities such as the translocationt(14;18)(q32;q21), which places BCL2 under the control of IGH promoter(in follicular lymphoma)^(1,2); or focal deletion of chromosome 13(del[13q14]), which leads to loss of a negative regulatory microRNA ofBCL-2, miR-15a 16-1 (in chronic lymphocytic leukemia (CLL))³. Thus,BCL-2 has been a rational therapeutic target in lymphoid cancers.

Venetoclax (formerly ABT-199/GDC-0199) is a first-in-class BCL-2inhibitor and has been recently FDA-approved for the treatment of CLL⁴.It displaces pro-apoptotic BH3-only proteins from BCL-2, allowing themto activate the mitochondrial pore-forming proteins BAK or BAX⁵. Despiteits potent clinical activity in CLL cases failing control withchemotherapy regimens such as those carrying disruption of TP53⁴,disease progression on venetoclax is becoming an increasing therapeuticchallenge^(6,7).

Citation or identification of any document in this application is not anadmission that such a document is available as prior art to the presentinvention.

SUMMARY

In one aspect, the present invention provides for a method of inhibitingtumor growth of a BCL-2-driven cancer in a subject in need thereofcomprising administering to the subject one or more agents capable ofinhibiting the oxidative phosphorylation system (OXPHOS). In certainembodiments, the method comprises administering to the subject acombination therapy comprising an inhibitor of BCL-2 and one or moreinhibitors selected from the group consisting of an AMPK inhibitor andmitochondrial electron transport chain (mETC) inhibitor. In certainembodiments, the BCL-2 inhibitor is venetoclax. In certain embodiments,the AMPK inhibitor is dorsomorphin (compound C). In certain embodiments,the mitochondrial electron transport chain (mETC) inhibitor comprisesoligomycin or antimycin.

In another aspect, the present invention provides for a method ofinhibiting tumor growth of a BCL-2-driven cancer in a subject in needthereof, the method comprising administering to said subject atherapeutically effective amount of one or more agents that induces orenhances expression, activity, and/or function of one or more BCL-2inhibitor resistance signature genes selected from the group consistingof those listed in Table 1, downregulated genes in Table 3, and/ordownregulated genes in Table 4; or an agent that inhibits expression,activity, and/or function of one or more BCL-2 inhibitor resistancesignature genes selected from the group consisting of those listed inTable 2, upregulated genes in Table 3, and/or upregulated genes in Table4. In certain embodiments, the agent increases expression, activity,and/or function of one or more target genes or one or more products ofone or more target genes selected from the group consisting of: PMAIP1,BAX, NFKBIA, IKZF5, BAK1, ID3, EP300, ZEB2, NFIA, BCL2L11 and OTUD5; orFNBP1, CD9, PLXNB2, TTC39C and DENND3; or XBP1, CYBB, PAG1 and DIRAS1;or CD9, PLXNB2, TTC39C, DENND3, ICAM1, GNG7, ID2, FNBP1, FBP1, ACY3,CDKN1A, GALM, PTK2 and CYBB. In certain embodiments, the agent decreasesexpression, activity, and/or function of one or more target genes or oneor more products of one or more target genes selected from the groupconsisting of: BCL2L1, BCL2L2, BCL2, MCL1, SRPX, RNF26, HSPB9, OR1S2,ADIPOQ, PIGF, CSGALNACT1, OTUD6A, SLC25A3, PRKAR2B, DNM2, SPHAR,APOBEC3C, RPL17, INMT, THADA, SBNO2, PRKAA2, BRMS1L, TRNAU1AP, CNNM3,ADAM33, PRKD2, FCHSD2, LOC399886, BABAM1, C1orf146, LMAN2L, ZNF460,TEX2, YRDC, ARHGAP11A, SPEG, FBXO9, USP54, SLC22A6, RPS4Y1, FAM71C,SH3BGRL2, HCRTR1, BST1, PHF10, UCKL1, ATG5, RPS15A, CDC20B, PPIE, TUT1,RPL36, HSD11B1L, MTERF4, PTS, S1PR4, HJURP, HMMR, BOLA2, DNASE1L1,OSGEP, TMBIM4, BTNL3, CHRM3, FBX015, KLK8, ASPN, STYK1 and SRSF6; orSYT11, PARM1, ROBO2, CD48, FCRL1 and MCL1; or PLCL2, KCNA3, TNFRSF21,CYP2U1, TRAM2 and RAPGEF5; or TSTD1, DNAJC12, TRAF3IP3, OPTN, DOCK10,PYHINI, CD48, P4HA2, PLCL2, AOX1, CDK6, GATM, GLUL, PAPSS1, MCL1 andGATM.

In certain embodiments, the tumor overexpresses BCL-2. In certainembodiments, the tumor is resistant to an inhibitor of BCL-2. In certainembodiments, the tumor is resistant to venetoclax. In certainembodiments, the method further comprises administering to said subjecta therapeutically effective amount of an inhibitor of BCL-2. In certainembodiments, the inhibitor of BCL-2 is venetoclax.

In another aspect, the present invention provides for a method ofinhibiting tumor growth of a BCL-2-driven cancer in a subject in needthereof comprising administering to the subject a combination therapycomprising an inhibitor of BCL-2 and one or more NF kappa B inhibitors.In certain embodiments, the NF kappa B inhibitor is selected from thegroup consisting of denosumab, disulfiram, olmesartan, dithiocarbamates,anatabine, BAY 11-7082 and iguratimod.

In another aspect, the present invention provides for a method ofincreasing sensitivity of a cell or population of cells to a BCL-2inhibitor or decreasing a BCL-2 inhibitor resistance signature of a cellor population of cells, comprising contacting the cell or population ofcells with one or more agents that enhance expression, activity, and/orfunction of one or more BCL-2 inhibitor resistance signature genesselected from the group consisting of those listed in Table 1,downregulated genes in Table 3, and/or downregulated genes in Table 4;or decrease expression, activity, and/or function of one or more BCL-2inhibitor resistance signature genes selected from the group consistingof those listed in Table 2, upregulated genes in Table 3, and/orupregulated genes in Table 4. In certain embodiments, the one or moreagents enhance expression, activity, and/or function of at least onegene selected from the group consisting of: PMAIP1, BAX, NFKBIA, IKZF5,BAK1, ID3, EP300, ZEB2, NFIA, BCL2L11 and OTUD5; or FNBP1, CD9, PLXNB2,TTC39C and DENND3; or XBP1, CYBB, PAG1 and DIRAS1; or CD9, PLXNB2,TTC39C, DENND3, ICAM1, GNG7, ID2, FNBP1, FBP1, ACY3, CDKN1A, GALM, PTK2and CYBB. In certain embodiments, the one or more agents decreaseexpression activity, and/or function of at least one gene selected fromthe group consisting of: BCL2L1, BCL2L2, BCL2, MCL1, SRPX, RNF26, HSPB9,OR1S2, ADIPOQ, PIGF, CSGALNACT1, OTUD6A, SLC25A3, PRKAR2B, DNM2, SPHAR,APOBEC3C, RPL17, INMT, THADA, SBNO2, PRKAA2, BRMS1L, TRNAU1AP, CNNM3,ADAM33, PRKD2, FCHSD2, LOC399886, BABAM1, C1orf146, LMAN2L, ZNF460,TEX2, YRDC, ARHGAP11A, SPEG, FBXO9, USP54, SLC22A6, RPS4Y1, FAM71C,SH3BGRL2, HCRTR1, BST1, PHF10, UCKL1, ATG5, RPS15A, CDCl20B, PPIE, TUT1,RPL36, HSD11B1L, MTERF4, PTS, S1PR4, HJURP, HMMR, BOLA2, DNASE1L1,OSGEP, TMBIM4, BTNL3, CHRM3, FBX015, KLK8, ASPN, STYK1 and SRSF6; orSYT11, PARM1, ROBO2, CD48, FCRL1 and MCL1; or PLCL2, KCNA3, TNFRSF21,CYP2U1, TRAM2 and RAPGEF5; or TSTD1, DNAJC12, TRAF3IP3, OPTN, DOCK10,PYHINI, CD48, P4HA2, PLCL2, AOX1, CDK6, GATM, GLUL, PAPSS1, MCL1 andGATM. In certain embodiments, the one or more agents enhance expression,activity, and/or function of one or more genes selected from the groupconsisting of: PMAIP1, BAX, BAK1, or BCL-2L11, NFKBIA, IKZF5, ID3,EP300, NFIA, OTUD5, or UBR5; or FNBP1, CD9, PLXNB2, TTC39C, DENND3,XBP1, CYBB, PAG1, DIRAS1, ICAM1, GNG7, ID2, FBP1, ACY3, CDKN1A, GALM orPTK2; or decrease expression, activity, and/or function of one or moregenes selected from the group consisting of: BCL2L1, BCL2L12, BCL2 orMCL1, ADIPOQ, PRKAR2B, PRKAA2, SLC25A3, RFN26, DNM2, PRKD2, ATG5, RPL17,RPS4Y1, RPS15A, OUTUD6A, FBXO9, or USP54, or SYT11, PARM1, ROBO2, CD48,FCRL1, MCL1, PLCL2, KCNA3, TNFRSF21, CYP2U1, TRAM2, RAPGEF5, TSTD1,DNAJC12, TRAF3IP3, OPTN, DOCK10, PYHINI, CD48, P4HA2, AOX1, CDK6, GATM,GLUL, PAPSS1 or GATM.

In another aspect, the present invention provides for a method ofscreening for one or more agents that increases a BCL-2 inhibitorsensitive signature or decreases a BCL-2 inhibitor resistance signatureof a cell or a population of cells that expresses BCL-2 comprising:delivering to the cell one or more candidate agents and selecting one ormore agents that: a) increases expression, activity, and/or function ofone or more target genes or one or more products of one or more genesselected from the group consisting of those listed in Table 1,downregulated genes in Table 3, and/or downregulated genes in Table 4;or b) decreases expression, activity, and/or function of one or moretarget genes or one or more products of one or more target genesselected from the group consisting of those listed in Table 2,upregulated genes in Table 3, and/or upregulated genes in Table 4. Incertain embodiments, the one or more candidate agents increaseexpression, activity, and/or function of one or more target genes or oneor more products of one or more target genes which comprise inhibitorsof the NF-Kappa B pathway, lymphoid transcription factors andmodulators, ubiquitination components, and/or pro-apoptotic BCL-2 familyproteins. In certain embodiments, the one or more candidate agentsdecrease expression, activity, and/or function of one or more targetgenes or one or more products of one or more target genes which compriseenergy-stress sensor signaling pathway components, a mitochondrialenergy metabolism component, vesicle transport/autophagy components,ribosomal components, and/or ubiquitination components. In certainembodiments, the one or more candidate agents increase expression,activity, and/or function of one or more target genes or one or moreproducts of one or more target genes selected from the group consistingof: PMAIP1, BAX, NFKBIA, IKZF5, BAK1, ID3, EP300, ZEB2, NFIA, BCL2L11and OTUD5; or FNBP1, CD9, PLXNB2, TTC39C and DENND3; or XBP1, CYBB, PAG1and DIRAS1; or CD9, PLXNB2, TTC39C, DENND3, ICAM1, GNG7, ID2, FNBP1,FBP1, ACY3, CDKN1A, GALM, PTK2 and CYBB. In certain embodiments, the oneor more candidate agents decrease expression, activity, and/or functionof one or more target genes or one or more products of one or moretarget genes selected from the group consisting of: BCL2L1, BCL2L2,BCL2, MCL1, SRPX, RNF26, HSPB9, OR1S2, ADIPOQ, PIGF, CSGALNACT1, OTUD6A,SLC25A3, PRKAR2B, DNM2, SPHAR, APOBEC3C, RPL17, INMT, THADA, SBNO2,PRKAA2, BRMS1L, TRNAU1AP, CNNM3, ADAM33, PRKD2, FCHSD2, LOC399886,BABAM1, C1orf146, LMAN2L, ZNF460, TEX2, YRDC, ARHGAP11A, SPEG, FBXO9,USP54, SLC22A6, RPS4Y1, FAM71C, SH3BGRL2, HCRTR1, BST1, PHF10, UCKL1,ATG5, RPS15A, CDC20B, PPIE, TUT1, RPL36, HSD11B1L, MTERF4, PTS, S1PR4,HJURP, HMMR, BOLA2, DNASE1L1, OSGEP, TMBIM4, BTNL3, CHRM3, FBX015, KLK8,ASPN, STYK1 and SRSF6; or SYT11, PARM1, ROBO2, CD48, FCRL1 and MCL1; orPLCL2, KCNA3, TNFRSF21, CYP2U1, TRAM2 and RAPGEF5; or TSTD1, DNAJC12,TRAF3IP3, OPTN, DOCK10, PYHINI, CD48, P4HA2, PLCL2, AOX1, CDK6, GATM,GLUL, PAPSS1, MCL1 and GATM. In certain embodiments, the cell orpopulation of cells overexpresses BCL-2. In certain embodiments, themethod further comprises exposing the cell or population of cells to anagent that modulates the expression or activity of at least one BCL-2antagonist of cell death (BAD) pathway component. In certainembodiments, the method further comprises exposing the cell orpopulation of cells to an agent that inhibits BCL-2. In certainembodiments, the agent that inhibits BCL-2 is venetoclax.

In certain embodiments, the agent is a small molecule, small moleculedegrader, genetic modifying agent, antibody, antibody fragment,antibody-like protein scaffold, aptamer, protein, or any combinationthereof. In certain embodiments, the genetic modifying agent comprises aCRISPR system, RNAi system, a zinc finger nuclease system, a TALEsystem, or a meganuclease. In certain embodiments, the CRISPR systemcomprises a Class 2, Type II, V, or VI CRISPR-Cas system. In certainembodiments, the CRISPR system comprises a dCas fused or otherwiselinked to a nucleotide deaminase. In certain embodiments, the nucleotidedeaminase is a cytidine deaminase or an adenosine deaminase.

In another aspect, the present invention provides for a method ofdetecting a BCL-2 inhibitor resistance signature in a subject in needthereof comprising detecting in a tumor sample obtained from the subjectthe expression of one or more genes selected from the group consistingof those listed in Table 1, Table 2, Table 3, and/or Table 4. In certainembodiments, the genes selected from the group consisting of: PMAIP1,BAX, NFKBIA, IKZF5, BAK1, ID3, EP300, ZEB2, NFIA, BCL2L11 and OTUD5; orFNBP1, CD9, PLXNB2, TTC39C and DENND3; or XBP1, CYBB, PAG1 and DIRAS1;or CD9, PLXNB2, TTC39C, DENND3, ICAM1, GNG7, ID2, FNBP1, FBP1, ACY3,CDKN1A, GALM, PTK2 and CYBB, are downregulated as compared to areference value. In certain embodiments, the genes selected from thegroup consisting of: BCL2L1, BCL2L2, BCL2, MCL1, SRPX, RNF26, HSPB9,OR1S2, ADIPOQ, PIGF, CSGALNACT1, OTUD6A, SLC25A3, PRKAR2B, DNM2, SPHAR,APOBEC3C, RPL17, INMT, THADA, SBNO2, PRKAA2, BRMS1L, TRNAU1AP, CNNM3,ADAM33, PRKD2, FCHSD2, LOC399886, BABAM1, C1orf146, LMAN2L, ZNF460,TEX2, YRDC, ARHGAP11A, SPEG, FBXO9, USP54, SLC22A6, RPS4Y1, FAM71C,SH3BGRL2, HCRTR1, BST1, PHF10, UCKL1, ATG5, RPS15A, CDCl20B, PPIE, TUT1,RPL36, HSD11B1L, MTERF4, PTS, S1PR4, HJURP, HMMR, BOLA2, DNASE1L1,OSGEP, TMBIM4, BTNL3, CHRM3, FBX015, KLK8, ASPN, STYK1 and SRSF6; orSYT11, PARM1, ROBO2, CD48, FCRL1 and MCL1; or PLCL2, KCNA3, TNFRSF21,CYP2U1, TRAM2 and RAPGEF5; or TSTD1, DNAJC12, TRAF3IP3, OPTN, DOCK10,PYHINI, CD48, P4HA2, PLCL2, AOX1, CDK6, GATM, GLUL, PAPSS1, MCL1 andGATM, are upregulated as compared to a reference value. In certainembodiments, if a BCL-2 inhibitor resistance signature is detected themethod further comprises administering a treatment to the subjectaccording to any embodiment herein.

In another aspect, the present invention provides for a method ofidentifying a signature gene, a gene signature, or other genetic elementassociated with a BCL-2 family function, activity or phenotypecomprising: a) contacting a cell or population of cells with an agentthat inhibits an anti-apoptotic BCL-2 family protein or a gene thatencodes the protein; and b) identifying one or more gene loci whoseactivity is modulated by step (a); thereby identifying a signature gene,a gene signature, or other genetic element associated with a BCL-2family function. In certain embodiments, the cell or population of cellscomprises a Cas protein or nucleic acid encoding the Cas protein and oneor more guides or nucleic acids encoding the one or more guides, whereinthe guide(s) target one or more nucleic acid(s) in the cell orpopulation of cells, whereby one or more nucleic acid(s) in the cell orpopulation of cells is modified, whereby the viability of a cell orpopulation of cells comprising the one or more modified nucleic acid(s)is modulated. In certain embodiments, the cell or population of cellscomprises nucleic acids modified by a CRISPR-Cas system comprising a Casprotein and one or more guides. In certain embodiments, the viability ofthe cell or cell population comprising the one or more modified nucleicacid(s) is correlated with representation of one or more of the one ormore guides. In certain embodiments, the cell or population of cellscomprises one or more gene knock-outs. In certain embodiments, theCRISPR-Cas system comprises a Cas9. In certain embodiments, the BCL-2family protein is BCL-2.

In another aspect, the present invention provides for a kit comprisingreagents to detect at least one gene or gene product according to any ofthe preceding claims.

These and other aspects, objects, features, and advantages of theexample embodiments will become apparent to those having ordinary skillin the art upon consideration of the following detailed description ofexample embodiments.

BRIEF DESCRIPTION OF THE DRAWINGS

An understanding of the features and advantages of the present inventionwill be obtained by reference to the following detailed description thatsets forth illustrative embodiments, in which the principles of theinvention may be utilized, and the accompanying drawings of which:

FIG. 1A-1I—Orthogonal genome-wide screens for genes driving venetoclaxresistance. a, Experimental schema of the parallel knockout andoverexpression screens using the BCL-2 driven OCI-Ly1 cell line (twobiologically independent experiments for each screen). b-c, sgRNAs andORFs frequencies, respectively, at different timepoints during thescreens (two independent experiments shown), black bars are mean+/−s.d.,two-sided t-test. d-e, Scatter plots showing the average log2fold-change (LFC) for each gene in both duplicates of theloss-of-function and gain-of-function screens, respectively (only geneswith LFC>−1 are shown). Genes with a significant increase of sgRNAsrepresentation (using the gene-ranking algorithm STARS, Broad Institute)and within the top-50 ORFs are highlighted. f, Dose-response curves tovenetoclax of 2 representative knockout OCI-Ly1 cells with relatedwestern-blots for quantification of the target protein. g, Differentialexpression of eight genes. h, Cumulative growth over time of each of thegenetically perturbed OCI-Ly1 cells. i, PKA and AMPK are centralregulators of cellular energy metabolism.

FIG. 2 —Expression changes related to acquisition of venetoclaxresistance and MCL-1 targeting. a, Dose-response curve of both thegenerated drug-resistant (OCI-Ly1-R) and the drug-sensitive parentalcell line (OCI-Ly1-S). b, Scatter plot reporting log 2fold-change (LFC)of both transcript (X-axis) and protein (Y-axis) levels betweenOCI-Ly1-S and OCI-Ly1-R cells. Red label indicates adjusted P-value<0.05 at the protein level (see Methods). c, Western-blot showing MCL-1,BCL-XL and BCL-2 proteins expression in OCI-Ly1-S and OCI-Ly1-R cells.d, Dose-response curves of OCI-Ly1-S to venetoclax and varying doses ofthe MCL-1 inhibitor S63845 (5, 10 and 100 nM). e, Combination indexaccording to the fraction affected (top) and normalized isobologram(bottom), Chou-Talalay method (see Methods). f, Viability of theOCI-Ly1-R line 24 hours after exposure to venetoclax 100 nM, S63845 50nM and both drugs (and DMSO as control), data are mean+/−s.e.m. fromthree biologically independent experiments, P-value is from ANOVA testwith adjustment for multiple comparisons. g, Relevant gene setenrichment plots based on differential RNA expression changes betweenOCI-Ly1-S and OCI-Ly1-R.

FIG. 3 —Investigating oxidative phosphorylation in the venetoclasresistant OCI-Ly1 cells. A diagram of the Seahorse assay describedbelow.

FIG. 4 —Metabolic changes associated with resistance to BCL-2inhibition. a, Oxygen consumption rate over time in both OCI-Ly1-S andOCI-Ly-1-R lines upon the use of inhibitors to derive parameters ofmitochondrial respiration (Seahorse assay, see Methods). b, Histogramplot showing the ratio of mitochondrial DNA (mtDNA) over nuclear DNA(nucDNA) in both OCI-Ly1-S and OCI-Ly-1-R cells. c, Histogram plotshighlighting quantification of the reactive oxygen species superoxide byflow cytometry in both OCI-Ly1-S and OCI-Ly-1-R cells. d, Oxygenconsumption rate and e, Extracellular acidification rate over time inboth OCI-Ly1-S and OCI-Ly-1-R lines upon the treatment by venetoclax,with or without prior zVAD treatment, or DMSO as control (representativeexperiment of 3 biological replicates). f, Dose-response curves ofOCI-Ly1-S to venetoclax. The cell line has been exposed to increasingdoses of the AMPK inhibitor dorsomorphin (left), the inhibitor ofelectron transport chain complex 3 antimycin (middle) and theF1Fo-ATPase inhibitor oligomycin in addition to venetoclax (right). g,Histogram plots showing the viability of the OCI-Ly1-R line afterexposure to DMSO as control, venetoclax 100/500 nM with and withoutantimycin 10 nM or oligomycin 1 microM. Data are mean+/−s.e.m. fromthree biologically independent experiments (panel b and g) and onerepresentative experiment of three biological replicates (panel a, d ande), * means P<0.0001. P-value is from two-sided two sample t-test.

FIG. 5 —The resistance circuit related to ID3 repression implicatesmetabolism. a, Western-blot for quantification of MCL-1 in geneticallyperturbed OCI-Ly1 cell lines. b, Dose-response curves to the MCL-1inhibitor S63845 of OCI-Ly1 cells engineered as indicated. c, Heatmapreporting genes differentially expressed at the RNA level between theOCI-Ly1-S and OCI-Ly1-R cells. d, Volcano plot showing transcriptschanges in ID3 knockout OCI-Ly1 cells compared to non-targeting sgRNAtransduced OCI-Ly1 cells. e, Western-blot for quantification of ID2 andID3 proteins in PRKAR2B (PKA) and PRKAA2 (AMPK) overexpressing OCI-Ly1cell lines. f, Histogram plots showing the viability at 24 hours ofsingle-cell clones from ID3 knockout OCI-Ly1 cells compared tonon-targeting sgRNAs transduced OCI-Ly1 cells after exposure todorsomorphin and oligomycin in addition to venetoclax. Data aremean+/−s.d. from three biologically independent experiments and P-valuesare from ANOVA test.

FIG. 6 —Clonal evolution in CLL patients developing resistance tovenetoclax. a, Somatic copy number variations in both OCI-Ly1-S andOCI-Ly1-R cells. Red is gain and blue is loss. b, Subclonal compositionand clonal evolution of 6 patients developing resistance to venetoclax.Driver mutations associated with each clone are indicated. c, Comparison(modal cancer cell fraction (CCF) with 95% CI) between pre-treatment andrelapse samples for select drivers recurrently observed in CLL or in thesetting of venetoclax resistance. d, Representation of the minimalgained region in the 1q locus across both the OCI-Ly1 cell lines and thepatient samples. e, Proposed model for venetoclax resistance.

FIG. 7 —Validation of gene hits from orthogonal genome-wide screens. a,Cumulative growth of cells during loss-of-function and gain-of-functionscreens. b, Log 2fold-change (LFC) of sgRNAs (4 per gene) for genes withsignificant change in representation during the loss-of-function screen(significance as determined by using the gene-ranking algorithm STARS,Broad Institute), horizontal line is mean and error bars indicate s.d.c, Scatter plots showing the average LFC for each gene in bothduplicates of the loss-of-function screen with known pro-apoptoticproteins and anti-apoptotic proteins highlighted. d, Protein expressionlevels in single gene knockout isogenic cell lines (2 lines per gene),before and after selection with venetoclax. e, Western-blot for thetarget proteins (PRKAR2B [PKA] and PRKAA2 [AMPK]) in ORFs transducedOCI-Ly1 cells. f, Venetoclax IC50 fold change of single gene knockoutisogenic cell lines compared to OCI-Ly1 cells transduced with controlsgRNAs. Data are mean+/−s.e.m., *P from extra sum-of-squares F test. g,Frequency of frame-shift indels in single gene knockout isogenic celllines before and after 2 weeks of venetoclax treatment.

FIG. 8 —Metabolic changes associated with resistance to BCL-2inhibition. a, RNA-sequencing of parental vs. venetoclax-resistantOCI-Ly1 cells, significantly dysregulated genes (adjusted P-value <0.05)with log 2fold change >2 indicated in red and log 2fold change <−2indicated in blue. b, Evaluation of mitochondrial membrane potentialusing JC-1 staining in each of the OCI-Ly1-S and OCI-Ly1-R cells. Dataare mean+/−s.e.m. from three replicates, P-value is from two-sidedt-test. c, Analysis of synergism of venetoclax with antimycin,dorsomorphin, and oligomycin. Combination index according to thefraction affected (left) and normalized isobologram (right),Chou-Talalay method (see Methods). d, Western-blot showing ID3expression in single-cell clones from Cas9 expressing OCI-Ly1 cellstransduced with ID3 targeting shRNA. e, Sensitivity of AMPK and PKAoverexpressing cells to venetoclax when used in combination withdorsomorphin (2 μM) and oligomycin (1 μM). Data are mean+/−s.e.m. fromthree biologically independent experiments, P-value is from two-sidedt-test.

FIG. 9 —Genomic investigations of OCI-Ly1 cells and primary CLL cellsfrom patients developing resistance on venetoclax. a, Somatic copynumber variations calling from WES data (AllelicCapseg plots andAbsolute segmented plots) of OCI-Ly1 cells. b, Mutation burden inbaseline and relapse samples. c, Bars plots related to subclonalcomposition inferred from cancer cell fraction (CCF) estimation usingthe ABSOLUTE algorithm (see Methods). Phylogenetic trees were builtbased on Absolute estimations. Driver mutations associated with eachclone are indicated in Table 8. c, Comparison (modal cancer cellfraction (CCF) with 95% CI) between pre-treatment and relapse samplesfor selected drivers recurrently observed in CLL or in the setting ofthis study.

FIG. 10 —Somatic copy number variations calling from patient WES data.AllelicCapseg plots and Absolute segmented plots of patient tumorsamples before (Pre) and after venetoclax (Post).

The figures herein are for illustrative purposes only and are notnecessarily drawn to scale.

DETAILED DESCRIPTION OF THE EXAMPLE EMBODIMENTS General Definitions

Unless defined otherwise, technical and scientific terms used hereinhave the same meaning as commonly understood by one of ordinary skill inthe art to which this disclosure pertains. Definitions of common termsand techniques in molecular biology may be found in Molecular Cloning: ALaboratory Manual, 2^(nd) edition (1989) (Sambrook, Fritsch, andManiatis); Molecular Cloning: A Laboratory Manual, 4^(th) edition (2012)(Green and Sambrook); Current Protocols in Molecular Biology (1987) (F.M. Ausubel et al. eds.); the series Methods in Enzymology (AcademicPress, Inc.): PCR 2: A Practical Approach (1995) (M. J. MacPherson, B.D. Hames, and G. R. Taylor eds.): Antibodies, A Laboratory Manual (1988)(Harlow and Lane, eds.): Antibodies A Laboratory Manual, 2^(nd) edition2013 (E. A. Greenfield ed.); Animal Cell Culture (1987) (R. I. Freshney,ed.); Benjamin Lewin, Genes IX, published by Jones and Bartlet, 2008(ISBN 0763752223); Kendrew et al. (eds.), The Encyclopedia of MolecularBiology, published by Blackwell Science Ltd., 1994 (ISBN 0632021829);Robert A. Meyers (ed.), Molecular Biology and Biotechnology: aComprehensive Desk Reference, published by VCH Publishers, Inc., 1995(ISBN 9780471185710); Singleton et al., Dictionary of Microbiology andMolecular Biology 2nd ed., J. Wiley & Sons (New York, N.Y. 1994), March,Advanced Organic Chemistry Reactions, Mechanisms and Structure 4th ed.,John Wiley & Sons (New York, N.Y. 1992); and Marten H. Hofker and Janvan Deursen, Transgenic Mouse Methods and Protocols, 2^(nd) edition(2011).

As used herein, the singular forms “a”, “an”, and “the” include bothsingular and plural referents unless the context clearly dictatesotherwise.

The term “optional” or “optionally” means that the subsequent describedevent, circumstance or substituent may or may not occur, and that thedescription includes instances where the event or circumstance occursand instances where it does not.

The recitation of numerical ranges by endpoints includes all numbers andfractions subsumed within the respective ranges, as well as the recitedendpoints.

The terms “about” or “approximately” as used herein when referring to ameasurable value such as a parameter, an amount, a temporal duration,and the like, are meant to encompass variations of and from thespecified value, such as variations of +/−10% or less, +/−5% or less,+/−1% or less, and +/−0.1% or less of and from the specified value,insofar such variations are appropriate to perform in the disclosedinvention. It is to be understood that the value to which the modifier“about” or “approximately” refers is itself also specifically, andpreferably, disclosed.

As used herein, a “biological sample” may contain whole cells and/orlive cells and/or cell debris. The biological sample may contain (or bederived from) a “bodily fluid”. The present invention encompassesembodiments wherein the bodily fluid is selected from amniotic fluid,aqueous humour, vitreous humour, bile, blood serum, breast milk,cerebrospinal fluid, cerumen (earwax), chyle, chyme, endolymph,perilymph, exudates, feces, female ejaculate, gastric acid, gastricjuice, lymph, mucus (including nasal drainage and phlegm), pericardialfluid, peritoneal fluid, pleural fluid, pus, rheum, saliva, sebum (skinoil), semen, sputum, synovial fluid, sweat, tears, urine, vaginalsecretion, vomit and mixtures of one or more thereof. Biological samplesinclude cell cultures, bodily fluids, cell cultures from bodily fluids.Bodily fluids may be obtained from a mammal organism, for example bypuncture, or other collecting or sampling procedures.

The terms “subject,” “individual,” and “patient” are usedinterchangeably herein to refer to a vertebrate, preferably a mammal,more preferably a human. Mammals include, but are not limited to,murines, simians, humans, farm animals, sport animals, and pets.Tissues, cells and their progeny of a biological entity obtained in vivoor cultured in vitro are also encompassed.

Various embodiments are described hereinafter. It should be noted thatthe specific embodiments are not intended as an exhaustive descriptionor as a limitation to the broader aspects discussed herein. One aspectdescribed in conjunction with a particular embodiment is not necessarilylimited to that embodiment and can be practiced with any otherembodiment(s). Reference throughout this specification to “oneembodiment”, “an embodiment,” “an example embodiment,” means that aparticular feature, structure or characteristic described in connectionwith the embodiment is included in at least one embodiment of thepresent invention. Thus, appearances of the phrases “in one embodiment,”“in an embodiment,” or “an example embodiment” in various placesthroughout this specification are not necessarily all referring to thesame embodiment, but may. Furthermore, the particular features,structures or characteristics may be combined in any suitable manner, aswould be apparent to a person skilled in the art from this disclosure,in one or more embodiments. Furthermore, while some embodimentsdescribed herein include some but not other features included in otherembodiments, combinations of features of different embodiments are meantto be within the scope of the invention. For example, in the appendedclaims, any of the claimed embodiments can be used in any combination.

Reference is made to Guieze et al., Mitochondrial ReprogrammingUnderlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies,Cancer Cell. 2019 Sep. 4. pii: S1535-6108(19)30373-3.

All publications, published patent documents, and patent applicationscited herein are hereby incorporated by reference to the same extent asthough each individual publication, published patent document, or patentapplication was specifically and individually indicated as beingincorporated by reference.

Overview

Embodiments disclosed herein provide the determinants of venetoclaxresistance by using genome-scale survival screens, phenotypiccharacterization of venetoclax-resistant lymphoid cell lines, andexome-wide sequencing-based analysis of drug-resistant cell lines andprimary CLL samples, discussed in further detail below. Thesecomplementary analyses revealed venetoclax resistance to involve notonly modulation of BCL2-family members, but also broader changes inmitochondrial metabolism. The present invention provides BCL-2 inhibitorresistance gene signatures and target genes that confer BCL-2 inhibitorresistance. The BCL-2 inhibitor resistance signature(s) may becharacterized by expression of the gene or gene products (see, Tables 1,2, 3 and 4 herein).

Inhibition of apoptosis is regulated by the B-cell lymphoma 2 (BCL-2)family and is a hallmark of many cancers, including lymphoidmalignancies. The first-in-class BCL-2 inhibitor venetoclax istransforming the treatment landscape of diverse malignancies, butresistance to this agent has emerged as a therapeutic challenge.

To systematically discover the determinants of venetoclax resistance,Applicants conducted parallel genome-scale knockout (loss-of-function(LOF)) (Table 1) and overexpression (gain-of-function (GOF)) (Table 2)genetic modifier screens of the BCL-2-driven OCI-Ly1 lymphoma cell lineafter venetoclax exposure. Applicants identified genes involved inregulation of lymphoid transcription (IKZF5, EP300, NFKBIA, ID3) andcellular metabolism (PKA, AMPK), and known BCL-2 family members.

Further, integrated transcriptome, proteome and functionalcharacterization of candidate hits of an OCI-Ly1 cell line renderedresistant to venetoclax (OCI-Ly1-R) from the parental cell line(OCI-Ly1-S), and genetic characterization of tumor DNA from patientswith venetoclax-resistant chronic lymphocytic leukemia implicate rolesfor both inner (oxidative metabolism) and outer membrane (MCL-1expression) mitochondrial adaptation. The RNA-seq and spectrometry-basedproteomics revealed coordinated dysregulation of transcripts (Table 3)and proteins (Table 4) in the resistant line originating from genescritical to cellular metabolism, cell cycle, B-cell biology andautophagy.

Of the transcripts and proteins significantly associated with theresistant cell line, only MCL-1 overlapped with the gene hits from thegenome-scale screens. Treatment of the OCI-Ly-R cells with the MCL-1inhibitor S63845 synergized with venetoclax. Given the dysregulation ofproteins critical to metabolism in both the GOF screen and in OCI-Ly1-Rcells, the role of metabolic reprogramming in venetoclax resistance wasassessed, for example by measuring the oxygen consumption rate. Comparedto OCI-Ly-S cells, OCI-Ly1-R cells demonstrated markedly higherrespiration levels, suggesting a state of higher oxidativephosphorylation (OXPHOS). Direct measurement of oxygen consumptionfollowing venetoclax exposure, consistent with impairment of OXPHOS byvenetoclax, demonstrates both an immediate decrease in oxygenconsumption and an immediate burst of glycolysis following venetoclax inthe OCI-Ly1-S cells, but not in the OCI-Ly1-R cells. In line with thesefindings, the AMPK inhibitor dorsomorphin and mitochondrial electrontransport chain (mETC) inhibitors synergized with venetoclax inOCI-Ly1-S cells. A transcriptome related to ID3 (identified as one ofthe LOF screen targets) was characterized in isogenic ID3-knockoutOCI-Ly1 lines. It revealed PRKAR2B overexpression as a key effect,indicating a role for ID3, and other lymphoid transcription factors inregulating metabolic reprogramming associated with resistance, andexposure of ID3 knockout lines to mETC inhibitors overcame resistance tovenetoclax.

To determine if there is a genetic basis for the drug resistance seen inOCI-Ly1-R cells, whole-exome sequencing (WES) results of DNA isolatedfrom the OCI-Ly1-R and OCI-Ly1-S cell lines were compared. A clearregion was amplified on chromosome 1q23, which includes MCL1 and PRKAB2(the regulatory subunit of AMPK). Similarly, a WES-based analysis ofpaired CLL DNA samples isolated from 6 R/R CLL patients just prior tovenetoclax initiation and at time of progression on venetoclax wasperformed. In the patient sample, non-silent somatic single nucleotidemutations in BCL2 or its family members were not observed at baseline orat progression, despite marked clonal shifts in all patients, but thepresence of the amp(1q23) as acquired at relapse after venetoclax wasobserved in 3 out of 6 patients.

Venetoclax resistance implicates changes not only for outermitochondrial membrane (MCL-1 expression) but also for inner membrane(oxidative metabolism). Such mitochondrial reprogramming represents anew vulnerability that can potentially be exploited throughcombinatorial therapy with metabolic modulators to overcome resistance,including through combinatorial therapies with metabolic modulators, toovercome resistance.

Accordingly, embodiments disclosed herein provide methods for detectingBCL-2 inhibitor resistance signatures, methods for treating tumorscharacterized by BLC-2 inhibitor resistance, and methods of screeningfor and identifying therapeutic agents useful in treating BCL-2inhibitor resistant tumors.

Diagnostic Methods BCL-2 Responsive Genes, Signatures and Pathways

The invention provides methods and compositions and identifiedgenome-scale loss-of-function (LOF) (Table 1) and gain-of-function (GOF)(Table 2) genetic modifiers of resistance to BCL-2 and BCL-2 familyinhibitors, such as but not limited to venetoclax. The invention alsoprovides for genes (Table 3) and gene products (Table 4) differentiallyexpressed between BCL-2 inhibitor resistant and sensitive parental BCL-2driven tumor cells. In certain embodiments, one or more target genes orone or more products of one or more target genes that have beenidentified as genes responsive to the BCL-2-related perturbations (lossor gain of function) are detected, such as for use as diagnostictargets. In certain embodiments, BCL-2 inhibitor resistant tumors have alower overall survival or increased risk of not responding to anytreatment (e.g., BCL-2 inhibition or standard chemotherapy). As usedherein, “BCL-2 inhibitor sensitive” may refer to a pro-apoptotic cell orpopulation of cells, an anti-proliferative cell or population of cells,or a cell or population of cells that is sensitive to treatment. Incertain embodiments, BCL-2 inhibitor sensitive cells are sensitive totreatment with BCL-2 inhibitors (e.g., venetoclax, aka, Venclexta,Venclyxto, GDC-0199, ABT-199 and RG7601). As used herein, “BCL-2inhibitor resistant” refers to a non-apoptotic cell or population ofcells, a proliferative cell or population of cells, or a cell orpopulation of cells that is resistant to treatment. In certainembodiments, BCL-2 inhibitor resistant cells are resistant to treatmentwith BCL-2 inhibitors (e.g., venetoclax, aka, Venclexta, Venclyxto,GDC-0199, ABT-199 and RG7601). A BCL-2 inhibitor resistant signature isa gene signature present in BCL-2 inhibitor resistant cells.

All gene name symbols refer to the gene as commonly known in the art.The examples described herein that refer to the human gene names are tobe understood to also encompasses genes in any other organism (e.g.,homologous, orthologous genes). The term, homolog, may apply to therelationship between genes separated by the event of speciation (e.g.,ortholog). Orthologs are genes in different species that evolved from acommon ancestral gene by speciation. Normally, orthologs retain the samefunction in the course of evolution. Gene symbols may be those referredto by the HUGO Gene Nomenclature Committee (HGNC) or National Center forBiotechnology Information (NCBI). Any reference to the gene symbol is areference made to the entire gene or variants of the gene, including thegene products (e.g., proteins). The signatures as described herein mayencompass any of the genes described herein. In some embodiments, theone or more signature genes are selected from those listed in Tables 1,2, 3 and 4 shown below.

TABLE 1 CRISPR-Cas9 LOF screen hits (STARS output): Gene symbols PMAIP1CACNA1D AJUBA FAM86C1 BAX ZNF706 TUBB8 PON3 NFKBIA DUSP7 PMAIP1 ZEB2IKZF5 HMGB1 BAX FATE1 BAK1 NCK1 NFKBIA CCDC71L ID3 NUDT1 IKZF5 VPS13BEP300 GRHL3 BAK1 CXCR2 ZEB2 LGR6 EP300 IZUMO1 NFIA TRNP1 BCL2L11 SLC22A6BCL2L11 LRRC47 OTUD5 ASNS OTUD5 HIPK1 UBR5 RAX UBR5 ZC3H6 TMPRSS15TMEM47 GALNT6 RAB9B NFIA C3orf58 FBXO11 FOXE3 REXO4 YES1 PRR12 CUL4BDTNB BZW2 FRMD7 MYLK C8orf44-SGK3 CDK2AP2 GDF1 RUVBL1 ID3 FRAT1 OR6C65QSNER1 ALG13 TFEB RC3H1 GAMT ALG11 SRP54 TAF9 KIF3C VIP YTHDF3 FAM122ABEND4 JCHAIN SPIN2A BGLAP BIK ASAP2 CPVL ATOH1 FTL ATG9B PDCL SNX19 FLG2STIP1 TMEM190 PDE5A TRAF3 KCNJ10 CT47A5 ARHGEF39 PDZD8 ARHGEF39 DEFB108BRAX ITPKB PABPN1 RNF219 CHRNA4 ACOT8 PRR12 MED19 HPR GABRG3 NR1I2 LAMB3STIP1 BEX4 LTBP3 ZFP30 KLK15 RWDD1 OR51E2 SLC5OA1 FOXO1 AZIN1 AJUBAFAM86C1

TABLE 2 ORF GOF screen hits BCL2L1 BCL2L2 BCL2 MCL1 SRPX RNF26 HSPB9OR1S2 ADIPOQ PIGF CSGALNACT1 OTUD6A SLC25A3 PRKAR2B DNM2 SPHAR APOBEC3CRPL17 INMT THADA SBNO2 PRKAA2 BRMS1L TRNAU1AP CNNM3 ADAM33 PRKD2 FCHSD2LOC399886 BABAM1 C1orf146 LMAN2L ZNF460 TEX2 YRDC ARHGAP11A SPEG FBXO9USP54 SLC22A6 RPS4Y1 FAM71C SH3BGRL2 HCRTR1 BST1 PHF10 UCKL1 ATG5 RPS15ACDC2OB PPIE TUT1 RPL36 HSD11B1L MTERF4 PTS S1PR4 HJURP HMMR BOLA2DNASE1L1 OSGEP TMBIM4 BTNL3 CHRM3 FBXO15 KLK8 ASPN STYK1 SRSF6 WWC2-AS2FAM84B PTCD2 C19orf47 AADAC TSSK6 MED9 NR2E3 VCP PMEPA1 CCDC144A DNAJB11BEX3 PRDX3 ZBTB9 FASTK BAAT AASDHPPT DHRS11 MAPKAPK2 XLOC_005244TMEM132A TYROBP PLGLB2 ADK TMEM151A MED18 KCTD16 NPL TM2D2 LYG2GLIS3-AS1 CFAP74 SNRK CGRRF1 RRAGD CTBP1-AS2 TFPI2 HACD1 GMNN PRRT2CCDC115 CDKN2A C2orf82 CCK PIAS1 S100A4 SNRNP48 RUVBL2 FAM234B TOX2LGALS9 BTLA GDPD5 LSAMP XLOC_I2_015937 C5orf49 IL36A LAPTM4A EFCAB1 GNAZRBP7 NECAB1 IGSF11 CA5B ERGIC2 GNPDA1 ARL16 PPID GPRC5B FHIT LTA4HLOC107987001 LYN SIAE STK32A MTERF2 MMP28 COQ8B TMEM147 CRYGD CD7 PBRM1ZMYND10 PIPOX FAM53C NOP56 NOTCH2NL IL10RB SRSF10 RHBDD1 GLYCTK MAXGPR45 FOS DUSP19 STAMBPL1 TGM5 TMEM131 CELA2B ZNF267 HSPB8 TAS2R10C1QTNF3 VSX1 CYCS USP30 C8orf4 ABHD12 SNX20 RBBP6 DIMT1 RPUSD2 IRF2ADAM18 AURKA CIAPIN1 STAM2 SLC38A1 Sf3b3 KHK GTF2B SLC36A4 ACVR1C OR10G2SLC12A9 EMC4 RAB40C FABP5 HIST2H3C OR4F15 ALDH1B1 UGT1A9 LOC554206 CA8SCD5 COMT AP1S1 CCL4 CD86 UBLCP1 CAP2 ABCA3 HCP5 PPP4C LATS1 H2AFJPKMYT1 GAGE7 FUZ POPDC3 MTFP1 C2orf69 TMEM133 EFNB3 C15orf39 BIRC5 SGK3ACTRT2 KDELR2 DOHH CD2 TFPI KLK1 POLR1D BCOR ATOH7 SLC17A8 FFAR4 SFTA2SYCP1 OR2A25 AURKB RET CACUL1 RBM43 NME3 RPLP2 FIGN MARK3 DHCR24 IL37NUFIP2 GATA1 APOBEC3D AKR1C3 PSMA8 CAMTA2 C5orf58 UBE2J1 SLAMF6 LPAR3METTL21C ITFG2 TVP23A C2 TRMT112 PDZD7 CTSE TMEM59 C20orf166-AS1 CT47A11FAM206A FYTTD1 SBNO1 CCL3L1 PADI1 SLC25A31 FCGR2A HYPM NEU2 POLR1C NPHP4C9orf62 FCGR3B XKR3 BUB3 TKFC BPIFB3 GPR65 PHF6 RCCD1 TP53I11 NDRG4TAS2R3 THAP8 RETN GPR176 LRRC8E ZNF436-AS1 ERC1 ADH6 DGKE HIST1H2ALABHD17A FTHL17 NME2 KBTBD4 AXIN2 TAGAP CT83 NEUROG3 TOMM7 EIF2B1 RSL24D1RANBP3 PTGFR Rpl3 XLOC_I2_009328 MKNK1 TECTB FAM104A NR2C2 C19orf25PPP1R3C TRAPPC13 IL20RB CLEC4A ANKRD16 MIR99AHG KCNK6 GAD1 LEAP2 MXD4DCK TPH1 C5AR2 BUB1 NBPF6 SELENOS DLST PLA2G1B PDGFRB SMYD3 ANK1 CCPG1TMEM120A ZNF181 RFTN2 SNRNP70 SPIN2A EFEMP1 CLIC1 CHRNA7 LINC00898CYBRD1 USP49 NUCB1 TCTN3 SPACA4 XLOC_I2_007488 OR2T33 SMOC1 CEACAM21MKNK2 UHMK1 PDE6H SLC35G2 TMEM80 GBP3 EFNB2 KIAA0391 PNCK ADAM7 C14orf1ZNF763 OXCT2 PHLDA2 PODXL XLOC_005712 FAHD1 MMP10 SAMD4A PAAF1 DYNC1I1NPY XCL1 FKBP7 MRPL49 CRMP1 GPR55 DDX60 TNFAIP8L2 SYT14 RPL30 NDUFS5C1orf220 OR6F1 C7orf26 SLC25A2 TAF1C MCOLN1 IL22RA2 LDOC1 ZNF488 DUSP7RSL1D1 GNL1 MCEE GAS2 CRYZ ZNF706 PTPRM ASPHD1 EQTN CAMK2B PTBP1 HAUS3CH25H EIF1AD FRMD6 NDUFB10 WISP3 CD276 Bnip3 EPB42 DPH3 HIST1H3C C9orf16MAP3K7 DIEXF ERN1 P2RX7 PURB XLOC_005466 ZNF624 CAT ARPC3 DDX1 HSPA8LOC107987587 KLHL1 CXCL3 AGTR1 KIR2DS2 CYP4F12 TARP TSR3 THAP10 FAAP24GPR180 UBALD1 SMIM11A CHPF TUBGCP4 HLA-DRA NPHS2 MRPL43 ABL2 ACOT6 PAIP1NF2 RAMP2 CCDC167 BEND7 LIPT1 C3orf18 TPK1 KRTAP13-4 PDP1 TXNRD3NB NEK7ELAVL2 GIF DLG3 Nrbp2 CDS1 FA2H VPS39 SPATA6L EPS8L1 CRY1 MKRN3 S100PXLOC_I2_013931 SPHK1 CKMT2 CNNM3 H1FOO NPPB SOX12 MVK CTDSP1 CCDC51 INSRZNF100 CD96 CCL4L1 LOC390877 HORMAD1 PFDN2 Pi4ka RUVBL2 P4HA2 KLK15CTNNA1 LENEP SGO1 EFCAB14 ABCG2 BAMBI NFKBIA ERICH2 NT5DC3 TRIM48 SNHG11RBM26 AK5 LOC650293 STXBP4 CD46 AHNAK NUP50 MRPL35 RBP2 GSK3A NCAPGZBTB44 PSMF1 LYAR FAM65B KIAA0408 CCR1 SLC25A18 USP7 TXLNA MIS18A LBPMAPK15 LOC613266 CDKL1 PPTC7 CATSPER4 FAM120C PRAMEF5 OAZ3 DOCK4 UQCR10POP4 TMEM234 C11orf84 EXOC3-AS1 ANXA5 SPCS2 ADPRHL2 ZNF776 PRKAR2AADGRG3 PCP4 MRI1 PPIH HIST1H3B CEACAM21 STARD7-AS1 IFNA4 CGB8 OLFM1CRCT1 INGX STK33 NUTF2 CPT1B HSPBAP1 TSPAN8 TNFRSF13B MND1 TMEM208 SRPRAARSG GAGE1 PIM3 RPN1 SMIM7 TNP1 RNF7 PRPF4B TAAR8 TMEM26 CYSRT1 RBP5IGFBP2 ZNF189 SCG5 C19orf54 ALG9 KRAS C20orf85 PPARA AKR1B1 VPS37ATSG101 LARP4 F2RL2 GPR160 ACOT11 NARS2 PLAU GLYAT PDPN NIPAL3 NRBP1CAPN13 CSNK1G2 NDUFA11 GALNT3 GPR37L1 CAPS PTGFR CDCA8 MRPL53 TRIM51MRPL4 CTBP1-AS2 MAPK7 EIF4EBP2 PGK2 TWF1 TMSB4X RSPH1 STK3 MTAP FAM45AHBP1 TTC29 TMEM82 FFAR2 ACAD11 LELP1 CCND3 KRT6A MYCL PYY TBL1YXLOC_008618 ZNF438 TMEM154 RIBC1 STAT1 LINC00602 LYRM7 SNF8 RACK1 CLK3CARNMT1 C5AR2 Emilin1 TRIAP1 NSG1 TAS2R41 HDAC6 DAP B4GALNT2 PPP1R1CMAP3K3 CLPS IP6K2 LTF PWP1 TBC1D7 CRABP2 DIRAS2 LOC148413 DSCR10 APCDD1FAM221A KCNAB1 PDLIM3 ZMAT4 LIMK1 LINC00638 XLOC_I2_008131 HCRTR1 ADAD1TYW5 TCEAL8 HAT1 TAS2R1 SNAPC1 LOC102724229 HNRNPUL1 CAMK4 AGTRAP PFDN5EEF1A1 CPA2 TMEM47 WDFY3 PAPSS2 IL17RC RUVBL1 MSRB1 NEK11 ASB13 PI4KBFAM228A FMO5 LXN SHMT1 PPIG PCDHAC1 HAO2 PSMF1 DIAPH3 ALG1 PTPRS ZFYVE21C17orf67 INPP5A NAGK PAK5 R3HDM2 PLA2G5 TKFC C5AR1 GK5 S100A10 CSNK2A1KIAA1586 HAUS4 TNFAIP1 Ergic2 HAX1 NECAP2 SCLT1 SLC30A8 FAM189B IP6K2SERPINC1 CKMT1A OAT PRDM5 TET2 AURKC STX2 GRM8 PXK LILRA4 MPP3 FBXL14GNPDA1 HSD17B1 RPN2 MRPS33 MGAT4C RPS27A AK5 CLEC18C PTPRN S100A6 LIPT1ZBTB37 FGF8 IMMP1L ATP6AP2 MPPED1 AQP4-AS1 MRPL27 DUSP23 POMP SCML4VENTX SCD5 SP3 DPCR1 PIKFYVE SAMD12 WFDC11 LOC107984064 ISOC1 POLE2RWDD4 TMEM64 SULT4A1 DDX19A PKD2L1 SLAMF7 SLC30A2 BNIP1 DEFA1 HIST2H2AA3RPS7 FAM64A WBP2NL PSMA2 BCS1L SUGCT HCAR1 IFT20 XAGE2 CHRM3 ZNF776 SNCACLIP4 GPX8 CDH19 DDX31 DMWD IL23A PITPNC1 CMPK1 GXYLT1 GSDMC TMUB2 CNDP1SPEF1 SPINK6 TMEM237 KARS VEGFB CCDC70 LOC653513 SLC25A47 ASCL2 RBM45PFDN4 UGGT2 GALR1 Mon1a ETFB HNRNPR RAB32 RHOC ENPP1 GPR39 COQ8BMGC70870 GPSM3 NUTM2F PSMB8 EGFR OR6C4 BTK PHACTR4 C3orf56 PDP2 BAALCZNF354A TMEM91 PAK4 DAPL1 TRHR OARD1 NUMB Hdac7 UGT1A6 POMK CCDC113 INSHILPDA BIK CAP1 PNKP NAT16 GINS3 CHORDC1 PPP1R36 SNX3 COX17 DNAJB3 KCNE2BCL2L12 XLOC_I2_013192 KPNA1 TMEM205 HPSE2 FGFR3 CDYL RUBCNL HK1 FCER1GLEF1 CD248 PAQR6 FAM173B RPL39L DNAH14 RNGTT HMGCLL1 SRP9 EPB41L4A-AS2FAM122C EVI2B LPAR1 CDY2A SUCLA2 RXFP3 PCDHB11 EPHB2 MC3R PITPNB UBE2L6TGS1 KRT18 CCL13 FLYWCH2 DUSP16 DHRS2 TSPAN16 TRIP10 CST9L ZNF829 CCDC68NME5 LRG1 LGI3 LOC100287896 USP36 CASP6 KCNK16 VEGFA TM2D2 THYN1 SQSTM1DNM3 CCDC60 LOC644936 SZRD1 PRSS21 SGK2 CPM OR6N1 C11orf74 TNF P2RY6RPL22 SLC25A51 TAS2R10 CCT6B ZDHHC15 ZNF124 BCKDK VIP LRRC45 LPAR3 MDH1FMR1 HMOX1 TROAP RPS12 REPS1 TYSND1 RRM2 XLOC_013491 MBL2 SPOCK3 FGF11AXL TTLL10 GMCL1 PCED1B RPL18A AVP MBIP DPY19L4 COPS8 LINC01547 GKN1EDNRA SLC12A8 VNN2 KLK7 RGL4 SERF1A CCNE2 ERP44 ATP6V1C1 RPLP0 GPR1 GNG7SCAND2P PPME1 SURF1 TMSB10 STOX1 CEACAM1 BRK1 SMUG1 MRPL15 LYPD5 MSR1CCNH PCBP4 COMT WFDC10A RPS6KA5 TRIB3 FGR LRRC25 KLK1 SPATA8 TFPT MKRN2SYT17 E4F1 ATRAID GCGR SIAH1 GPR19 THRAP3 PSKH1 CELA3B CNIH3 PLGRKTGPR132 CCM2L FASTKD1 NT5C1A KIAA0368 FES ODF2 CYCS GBA2 LHFP PCDH12NELL2 ACAD9 NAGK PI4KA APOC2 TMX1 HDC PRKCE TECRL ASTE1 CD22 LBH DHRS7RHOG MSRB3 SKA1 C9orf72 FAAP24 STARD5 SPHK1 BEND5 SELENOW DHX29 SLC14A1ZNF398 SSBP3 MRPS11 ATP5C1 RAMP3 C1QTNF2 PDCD2L CATSPER2 LOC102724993PDLIM2 ATP5G3 IFRD2 OR4C6 FBXO3 RAB5A CACNB1 IL5RA ASAH2 IFT46 SRPK3QRFPR PAX4 MAPT TRAPPC6B MGAT1 DRG2 GPR50 EEF1D AP2S1 EPB41L3 CABP7 PTMACCDC58 CCL25 FBXO38 IGFBP4 TSLP STK38 CDKN2AIPNL D2HGDH ASIP FBXO10OR2G3 TBPL1 C16orf59 OR5I1 PIM1 PFN1 KCNA10 PLEKHA7 TUBE1 YTHDF2 ZNF571AIFM1 PSKH1 SAP130 IFNL1 TMEM208 NOP2 TAF5L HIST1H2BF PRSS48 TAAR8TNFAIP3 SYPL1 OPN1SW FMO2 REM1 BSCL2 DND1 PAQR3 SCIMP PIK3C3 TSR1 GRTP1TAGLN2 C1QTNF1 CDK3 STAR SMG1 LGI4 PDGFRA SLC25A4 SF3A3 BORCS8-MEF2BCYP2A6 CASP5 NRG1 LRWD1 MNAT1 MAGEA4 ANGEL1 TAX1BP3 DDX47 INS-IGF2 PAK1N4BP2L1 WDR86 RCAN1 PAK1 PHF20L1 XG ACP6 SLC28A1 TK2 ASNS CLEC7A LCKZNF778 METTL8 ATP6V1G2 RIPK2 FCGR3B ANXA13 NDUFB1 ASAH1 DTWD2 RLIM PLIN3TUBB3 TRIM31 HCAR3 SOAT1 XLOC_012222 WBP2NL COMMD1 SYT4 PEX19 CHRNDCALHM3 ANP32A-IT1 USP38 EIF4A2 MTMR9 TFPT KRT83 WDR47 UBE2K SH2D1BTNFRSF9 GPR50 TMEM159 ATG14 CSF1R LSM10 WNT3A WDR4 SPINT1 H1FX-AS1 TAF15PCDHA10 LRFN4 ZNF549 STK40 LINC01270 DYNC1U1 IDNK DNAJB7 HOMER1 SLC39A12MYOCD AK2 TANK MED22 SLC35B4 TESK1 ATF2 PRKCSH SENP8 S1PR5 CELA3B MGST2LPAR4 NR0B2 GPM6B FAM131C RASL12 ZNF669 TINF2 KLHL29 RAF1 SCGB1A1 ACBD4ST8SIA4 IRF2BP1 CHPF2 FOXJ1 MRTO4 NUMB RNF167 GABRA6 ALDH18A1 PODNL1C20orf96 TAS2R40 GPRIN3 SLC25A41 CRIM1 NCMAP ADRB2 DDX20 SCYL2 POLR2MCCL23 FDFT1 SCYL1 EMC3-AS1 ORC4 CABYR WNT4 NIFK NREP SCO1 ACYP1 TEX37CPEB2 ERO1A STK40 MRPS30 LIG1 RNASE3 STK38 PRND CCKBR TMC5 OR6V1 CADM1ZC3H7A TAZ HAUS2 TNFRSF19 ANXA4 CLCA2 GATS GJB2 CHRM3 EFS ENC1 PLEKHH2SPATA6 IL12A FKBP8 ENOPH1 CCT8L2 TIGD7 EIF4E3 S100A11 ZNF436 FBL POLR3FSUSD4 ZNF483 EEF1G MTUS1 CD28 NRP2 GDPD3 CSNK1G1 DNAJB1 IST1 RFWD3 ACTR8CDH6 SPRR2A STMN1 CD9 SLC7A1 LOX Ola1 ASMTL-AS1 CIART RGR PLAC8 UHMK1MAPT DTX4 ZNF419 SLC35A2 CEP126 RARG ZIC1 GLRX2 EIF2AK4 STX18 DIMT1GUCY1A3 PAPLN SLC36A3 XLOC_013119 TRMT12 XCR1 FABP12 BOLA2 KIAA0930 NAT8SPACA3 CALM1 XLOC_I2_008203 SLC51B WDR92 CCNE2 ATPIF1 GHRH CAMKK1XLOC_013643 ABO VPS26B KCNE3 PQBP1 LINGO2 HPS1 YPEL1 PCDHGB3 APOH ARF6KIAA0040 PTCHD3 WRAP73 TMEM211 RPL23AP64 LTF MTNR1A MYOG SHISA4 KITRAB39B FAM172A CETN2 GJA5 GPN2 NCK2 OIP5 PRKG1 OSCP1 RHOBTB1 PIK3R3TSEN15 HTR6 TSSC4 BACH1 CRBN HM13 CAPZB PRKAG2 C20orf24 EBF1 SBNO1ARHGEF7 CASP2 TTC16 SETD7 MAPRE3 TRIP6 BTN2A1 SLC6A15 ZCCHC7 PPAN RTN1KIAA0087 RBKS BPGM HVCN1 CA12 MELTF M1AP FAM60A LHB SRPK3 PRDM14 PTCD1NRM NFIA TEFM TALDO1 FAM46A SULF2 SYT11 NR1D1 POLR3C SERPINA4 ZNF695KRTAP3-3 PLSCR1 NT5C1B DYNLRB1 STK35 BMP7 PSPC1 DPEP2 IFNA21 SRP9 MRPS36AGL CSNK2B SLC31A1 CCNYL1 CSNK1A1L KRT8 ASF1A MOBP QARS TEKT2 GADD45BELK4 VWA5A TSPYL5 DAGLB TRIM16 LRFN4 ELANE OXNAD1 EPHX1 AK2 ZIM2 H2AFVPTH1R MB21D2 STX3 NEK8 EDA C1orf27 VAPA UNKL MSS51 ISLR2 STK26 ADGRG5PAQR7 ZNF501 MCRIP2 CAMK2A CNST TSSC4 MSH4 SLC35E2B C4orf3 NME8 FAM207ALINC00238 OR14C36 MAX ENSA MT1A OPCML RASSF5 PRKD3 TMEM8B DOCK8 AKR1C2RPS19 TMEM106A FAM212B CYFIP1 TMEM9B ZSCAN20 C1QTNF9B-AS1 TEX13A TECTBAURKB ADD1 AKR7A3 NIT1 SERPINB10 SLC27A6 PIM2 PIM1 ASPH SPINT2 ADAP1ACYP1 CPXM2 BMI1 CDC26 YWHAQ RGS17 TP53RK TBC1D19 ADRB2 COX6A1 CASC2SMR3A TSPAN5 DBF4 HCFC1R1 ZNF281 C4orf36 SRMS SHD ORMDL1 DAND5 GPM6ABEND5 ZBTB10 EXOC4 AKAP14 ZRANB2 C20orf173 GALNT4 FTL FGF6 SGK1 KBTBD3GORASP1 ZNF285 TATDN1 FAM90A1 GPR84 PRMT8 CKMT1B H2BFWT HK2 ZNF468C2orf40 OPTC FAM166A HIST1H3F FAM189B PYCRL PWP1 RSPH3 PKN2 PEX7 PRUNE2CPA3 FBXO7 TIAM1 FAM222A ITM2B C9orf163 LSP1P3 COQ10B ZNF792 ACTRT3RAP2C MAL IFNA10 CCDC27 CSMD2 RFXANK ING1 CD40 THOC3 KRT18 PSMB4 ESRRGEWSR1 DCTN5 ZNF295-AS1 C12orf57 DCAF5 DKKL1 FAM118B CACNG2 ALDH1A3 Myo5cKCNS2 SMIM14 ATG9A EGFR LINC00312 MYH7B TP53TG3 WWP2 PRKACB LOC102724428DEUP1 SOX14 MPP1 FGFRL1 ASRGL1 NUBPL CCDC117 SCPEP1 MAP2K3 AK4 MTMR14ARSE MAGEB3 MAPK10 MAP3K5 TSSC4 RNF167 FEM1C IMPA1 PLD3 WASHC1 NME4 GJA4PTCHI PIM1 PIM2 G6PC2 FBXL13 GP1BA KLHDC3 MRPL9 KRT6B ASB2 FGFR4 JAM2REG1B XLOC_I2_009889 ROM1 KLHDC3 MAATS1 MITF DAW1 ARHGAP25 DNASE2 ERBB2CDKAL1 Adamtsl1 C2orf83 CCL18 CNBD2 NR2E3 STRADA PPIA UBAC2 CXCR5 COPS5BCDIN3D DCAF7 C19orf66 IRF4 GALK2 NDNF ELSPBP1 SMCO3 PDK1 ALPI CXCR4STAG2 KRT40 GATC GABRB2 RDH12 TSHR CXCL16 MEMO1 PRPSAP1 DUSP14 ZCCHC17ANXA2 IGLL5 P3H1 GCC2-AS1 GNG10 RAB37 GRP TAS2R16 TRIM31 CDK7 IWS1 TKTACTR10 FAM89B WBP2 ILKAP TMEM54 OPN4 EEF2KMT ZNF768 TICAM2 NUDT10 VN1R4TBCCD1 AGTPBP1 PTHLH NSUN5 ATP2B2 B4GALT5 TMBIM1 SERPINB9 C4orf26 RASSF1ISM2 SPPL2A GSTZ1 C4orf19 OR10K1 PARL GRK5 SMOC1 JKAMP GUCA1C CST5 PRKCZC2orf73 DEPDC7 GSTT2B LRIT3 PRR14L SELENOT SPINK4 BLM PRELID3A ERCC8HOMER1 VANGL2 AGMO CALD1 METTL6 PSKH1 TMEM43 LINC01341 NUDT11 CTHZSCAN26 KCNAB2 LOC90768 CCL21 CLDN8 FTO CLC MAPK1IP1L PCDH10 CHN2 STK4FAM83F MED7 CRABP1 SPPL2C FAP SBDS C10orf91 CALHM1 HIST3H2BB TMTC1C15orf54 UBE2W GABRR1 ART3 FASTK NEK9 SPATA17 LETM2 CFAP52 OXLD1 CAMK2GMMADHC HLA-C TTI2 ETFRF1 HEXB MRGBP 42981 AP5M1 SGK3 C8orf49 LSMEM2ZNF322 PRTN3 NTMT1 MYO19 TMEM218 LGALSL WDR33 PTPN20 USP16 ICOSLG MIXL1ANKRD20A4 CACNG4 SH3BGRL3 EIF3D COMMD6 ST6GALNAC4 YIF1A MUCL1 MRPL21FGFR2 COASY OR8H2 XLOC_I2_014086 SNRPE LOC107987235 TGFB2 OR10X1 TDGF1XLOC_I2_009790 EIF5A2 LTK VASP GORASP1 GPR119 LAPTM4A GTSF1 GPR151KRTAP4-1 SCIMP GLRX ALPK1 AKT2 PRSS2 SPATA18 UCP2 TMEM246 GPR61 DUSP22CIDEB NKAP PIM3 CD226 ARL17A STX8 SHISA3 CD86 PKM MLLT11 ADM PPP6CTREML2 FYN XAF1 GLT8D2 DCAF12 OLR1 CYP2A7 CENPA NEMP1 EMG1 LDLRAD4 RAB4ACCDC26 TTC25 CCNL2 FAM227B PURG ZNF496 NMBR SERPINF1 TMEM259 CDK2 IL23ACDK10 KPNA2 APCS COMMD8 XLOC_I2_000581 RNF216 TP53 AIPL1 JAK1 GOSR1 SDSLSDS SLC25A35 FRK GLMP PSMD2 MAGEA10 PGC CD300LB CHRNB1 CD302 AP3M1 OMPCBWD1 RAB30 HMGB4 CASC10 AGPAT2 PGAM2 LSM2 PLPP7 MTUS2 TMEM242 GPX4PSMG1 NUBP1 CYP2F1 PDE6G OR10X1 ERLEC1 ANPEP KAT2A PDDC1 FANCI OXCT2ABCB9 OR2T10 IFNA8 TMEM196 LIN9 LY6H APOPT1 NARF ZNF24 CRACR2B ULBP1LSM1 PSTK NLK ATP5J ERICH6 MRPL34 ATP6V0A4 NACC1 TMCO6 MFSD10 CYSLTR1NGLY1 OR56B1 IRAK1 CMPK1 PAK4 ADGRD1 RDM1 TMEM43 SSTR2 OLFM3 SLC50A1KIAA1644 MAP4K3 C5orf64 PSENEN TMEM184B PHTF2 TRNT1 RNF11 CCDC88C PIK3CAUBA52 GLRA3 BAG1 ST3GAL5 TBC1D29 BCL2L12 XLOC_I2_005179 GPR139 PKD2PAQR7 DPY30 TTC26 FAM26E FRZB SYT1 TNNT2 WDR31 TUBB3 UBR7 ANAPC10 RNF130SFXN5 NME7 MTUS1 DEPDC1 LTB4R CNN1 THNSL1 NR2C2 LIM2 DIP2A C20orf203SC5D CHMP5 CRK MICU2 EPN2 GAL DEFB123 CXCR3 SERPINA6 MAPK12 MIF FAM166BKLRC1 PROKR1 GBA MFAP4 LSP1 XLOC_I2_015578 STARD3 KDELC2 KLK1 IMP3 FDPSRC3H2 STPG1 JRK ROPN1B XLOC_I2_007835 CXCL9 PMS1 BPIFC FUNDC2 OCIAD1C14orf159 TUBB6 DHRS2 DEFB127 DRD2 TMEM268 MAPKAPK3 ECHDC3 CRYM PSMC4ANKS6 PTGDR2 MAP2K3 ENKUR MAP3K19 LAMC1 CD300C CNKSR3 XLOC_I2_009492SMPDL3B KRTAP13-3 COLQ VCY RTP4 C3orf35 GDF15 CD8B WNT2 LOC101927905RHOXF2 MRGPRD MBOAT2 RNF151 ACTR3 ESRP1 NRG4 GPR32 CHRNA4 LRRN4CL LATS2CPNE8 RABL2A TSPO2 C10orf53 PPIL3 MAP3K7 ZWILCH CELA3A CDK5R1 FUOMAKR1B10 GMPPB LSM5 ICK NEDD8 FCGR3B AATF LOC653513 ING5 SH3GL2 KCNIP4ZNF784 UCHL5 LRTOMT ABCB1 PML MAGED1 F2R LTA KLHL28 SNX10 CRP HMGB3 SLPIALDOC UHMK1 KDM4B H1FNT CDK7 TNFSF14 PSMD6 LHFPL5 RHBG YIPF2 TBC1D13DDR1 RGR RAB25 WRNIP1 TPRN ASZ1 FCAR VIPR2 TRIM73 GABARAPL1 CDC16 APOECAMK2N2 PLD5 MPLKIP RGS13 PLA2G1B SRSF10 FDXACB1 EIF5A C7orf13 RYBPACTR6 MCFD2 TNFRSF21 CIB2 TLE1 STAP2 WDR77 NAA38 Hoxa10 IL20RB CPE MAELACP1 POLE4 CCDC28B DNAJC2 DGCR14 SULT2B1 MAPRE1 DNAJC22 VPS28 IRAK4SLC18A3 CDCA4 NDST1 XLOC_I2_006804 SSR3 ING5 FMN1 MYL6 PDIK1L PLSCR4CARD8 PTGER4 ZFP14 SPX CDK2 GRID1 TPX2 TMEM52B NMUR1 KLHL33 HS3ST3A1TAS2R20 ERBB2 CCDC148 KCNE4 AARD EIF1AX NPM1 TESK2 DUSP23 PRR15 CSTF3NUDT5 GMDS HMBOX1 TMEM74 HLA-DQA1 MPC1 SPIN2B TULP1 MAPK10 ALDOB HPNCSNK1A1 C18orf54 BTF3L4 HRAS STX7 H1FNT GPR26 RDH12 GNAT2 XLOC_013923XLOC_002741 CIB3 GNPTAB YWHAEP7 SSMEM1 NUDT12 ZNF705D CACFD1 MLF2 NUSAP1TMEM53 KRTAP19-4 PDK3 HCK MRPS14 CCDC25 STEAP4 EHD4 B3GNT6 RPRD1AGRAMD1B SNHG7 RPL23A ANKRD44 SIRT4 ENTPD7 CD36 TOX PSORS1C1 ABT1 GALNT16RPS2 PDK4 RNFT1 ARL17A CNR2 TPT1 TRAPPC2 EFCAB12 CORT NMUR1 FAM175APPIL6 FDPS TTLL2 IL1RL2 NUP62 PEX5 LINC00671 LEP SLC25A43 DEFB118 NPY2RGBP5 PIM2 B3GNT9 STAMBP PROSER3 RFPL4B RALYL MYOZ2 UPRT PPP1R26 SUV39H2XLOC_I2_004840 OGFOD3 NRXN3 LOC440461 SRD5A1 ITLN2 RPL23A CHCHD4 APOC1XLOC_004269 SKP2 TNFSF9 XLOC_013901 UBE2W IKBKB LINS1 IFNA13 SH3RF2MRGPRE CCKAR SETD3 NRIP2 TPK1 IL23R PLSCR1 KIR3DX1 CIRBP SH2D4A CHRNA7SATB2-AS1 GLIPR1 MCAT GTPBP10 DNAJB2 STK26 MAFG SMLR1 MCM5 PRKAR2A TIPRLRAD51AP1 PITX1 HAND1 RPIA TACR3 ACP1 OR14I1 FAIM EPHB3 CNTN4 GPR157ITGB8 LINC01580 PTGES2 ADAT2 DEFB119 ING3 RASL11A GRK4 PTPRCAP C6orf25FZD1 HIST1H4J HNRNPC PLSCR5 HNRNPH2 KCNJ11 NTSR1 GPN1 OPCML ATP6AP2LOC100101148 CDRT15 KRT36 PLCG2 NDUFA8 CLMP OR5H6 MT1M MAP3K20 QKIHIST1H2AG NTSR2 PFKM FMO4 SH2D1A TMEM120A HTR4 FAM107B GNG7 OR8G5 GPR146ATAD1 ANKRD13A HMGN4 BDH1 UBXN2B FGF22 THUMPD3 SLC25A10 TESK1 MAPT FRG1SLC35E2 GNG8 DUSP22 XRCC4 IP6K1 C3orf33 FXYD2 FXYD1 SMCO1 SNX24 MDK NOP9PLEKHF1 KDELR1 TSNAX RPL6 HOOK3 DQX1 PSMD2 CLIC5 MAD2L1 HSF2 VSIG1 CAV3CHST6 LMBRD2 WDR90 GHSR SYNC CDK5 TCTN3 GPX7 MAP3K9 MBNL1 CDK17 GGTLC1GPN3 SIGMAR1 SC5D RCBTB1 HMGA1 HOOK2 OR11H4 TRIB3 UBE2V1 SUSD3 CHRM2HMGN2 OTUB2 CCL2 AURKA LIMS3 MGARP REEP3 CYB561A3 SLC10A7 FAM109B PEF1CLUAP1 KYAT1 CTRL FAM127A RBM7 FFAR1 CD244 MAS1 CTRC HMGCL SDF2 PTGIRPCMTD2 COL20A1 GPR34 PTPA GPR63 CD3G PTAFR CTSK SPCS1 HIST2H2AA3 XPR1MOK NMT2 XLOC_I2_009281 NXPH2 GFM2 TRAF4 RALY PPP1R32 PPP1R3B SSBP3IFT74 TMSB10 RRM2B ACPP EIF3E CBFB RXFP2 AKR1B10 Tex261 GFRA2 CPD EDDM3AAK1 SAV1 FOXD4 TM6SF1 ASNA1 SLC7A11 DEFB105A ARHGEF26 EIF3G PRH2 CSF2APOOL BPHL ARL13A RSL24D1 MAP4K4 MRPL43 ARHGEF3 UCK2 STATH ARL6IP6 MAP6TPT1 SPHK1 RCSD1 C4orf33 SUPT4H1 KCTD17 MAN2B1 PEX10 NCCRP1 XLOC_005602SLC25A6 PMCH B3GAT2 ZFAND6 DDIT3 PPARG MED20 SLC29A1 LOC107983965 DYNLT3LOC439933 TOE1 TCEAL1 SCD5 ZNF671 SPHK1 GPR182 CHTF8 NUDT1 B3GALNT1RPP30 NUDT3 MAPKAPK2 SCGB1C2 ABI3 PCGF6 GLRA2 GYPB CRTC3 EMCN CCSAPPRR19 FAM83A XLOC_I2_006131 TNFSF9 ATG7 PVR SELENOF CXCL13 TMEM256ZNF597 EFCAB2 S100A16 THPO OTUD6B MRGPRF XLOC_010651 ZNF75A SRSF2 PCCBSLC22A15 PELI1 EGFR NIPA1 TMEM126B ZDHHC20 SYNE3 NAT2 AQP3 ATPAF2ARHGEF9 TESK1 QRFPR CPT1A RND3 IRAK1BP1 GALNT15 EPM2AIP1 TOP3B PDXKTPD52L3 RAPSN PAK1 HLA-L GPR143 TSHR AGK CX3CL1 CYSLTR1 C8orf31 NHSL2LMNB1 C10orf35 C5AR1 FAM199X POU2AF1 TP53TG5 CAPSL MMP28 GOSR2 HIST1H2ACCXCR3 SPRY4 NO_MATCH_203 IL21 ZNF662 ZDHHC5 FADS3 NO_MATCH_181 NEK6TOMM20 NCR3 UCN2 TMA16 GCDH BCL2L13 CSNK1G1 METTL18 RAMP1 STK33 BRAT1BAK1 CMTM8 OR1D2 HDHD3 EGR1 SPRYD7 ABHD17B NPM3 ASTN2 NO_MATCH_25 TWF2TNFAIP8 RHBDL2 RPSA GPR87 FHL3 MXRA8 IPCEF1 ERP29 ZG16 TRIB3 STK16 AURKAFAM220A SIK3 NOTCH2NL FNTA SH3BP5 LRRC42 TUBA1A TAF6L HUS1 RPL6 MAPK14SRSF8 MOG BID AMHR2 PSMB5 PABPN1 RAB27A CUEDC2 CDK5 VRK3 NDUFV1 SLC25A51TOMM6 QPCTL EGFR CCL14 GPR162 PUDP CMPK1 TNFRSF6B TAS2R45 TAS2R8 AUP1NKIRAS2 PRKAG3 GDF11 C12orf76 CSAG3 TMEM116 RAPGEF5 MAPK8 TTC12 COX8CRPL4 IFNA6 APOF SLC39A9 CDK9 CFAP20 ATP12A MZT2B NR2C2AP GRK3 SNX31TSGA10IP CHAC2 ERBIN CDK16 AKT2 FRYL GFOD1 MGAT2 OXER1 PRRT1 GPSM1TADA2A PIM3 CREB3L1 AKAP7 PIGH NO_MATCH_209 ARL6IP5 TMEM231 MIR7-3HGHSDL1 CTRB1 RPF1 SNAP47 UBE2S SOCS3 CCDC172 ORMDL2 URB2 POGLUT1 C9orf40POLR2C ZFAND2A EGFR HESX1 HSD17B11 P2RY4 PIP5KL1 MLIP NUP62CL KRTAP10-5RNF148 P2RX6 HNF4G EPDR1 CYSTM1 CPO CDK6 PAFAH1B1 C1orf35 C8G RELL1METTL21A KIRREL2 NOTCH2 MMGT1 BAGE TMC8 XLOC_I2_013503 PYM1 ADAM2LINC01366 MYO1D GCFC2 UBQLN4 BCAS4 HK2 LDLR ANGPT2 CTRC CLK3 NAB2 DNAJB5VIM NO_MATCH_218 WDR5 SLC17A2 DYNLL2 GPR148 ARMCX6 SEMA7A SLC35C2RPS6KB2 RPS19BP1 OR5AP2 RPS6KB2 TMEM254 HOXC11 COPS7A NO_MATCH_12 STK3CPA6 PRR4 WFDC6 NEK2 HCRTR2 SRD5A1 OXGR1 PPM1B GCA C1orf226 INSL4 SCAPERHTR2A UBE2D4 C11orf74 GNG2 AGBL3 TXNL4B SUSD6 POMK APOC4 Mchr1 RNF111CHAC2 KAT7 AURKB FBXO46 GSTM3 KRTAP10-9 ATP6V1C1 SULT1A1 ALKBH4 FGAHSD3B1 CDK2AP2 CYP27B1 CSF1R PIP4K2B GABRB2 MAPT TMEM71 COMMD10 PAQR5ZNF417 RBMY1J MAGEC3 SPEG ZG16 PSG3 RBSN XLOC_I2_011027 HIST1H2AKANKRD50 MARCO NDUFA13 NO_MATCH_233 SUMO2 TNIP3 HIBCH C16orf52 SLAMF1EMC2 ST14 EGFR TEX19 FAM216B CPNE2 G0S2 ECHS1 CFP CCNDBP1 TCL1B PDCD1LG2TCEAL9 TUBB2B PCMT1 PLEKHF2 SGMS2 MTX1 OR1OS1 ZNF24 IDI2 CD99L2 MPP6SSUH2 ACTC1 PTGDR2 MACROD1 AMIGO1 DYM STK40 SLC9A2 PARVA XLOC_003385LIME1 C22orf29 ZNF449 WLS PQLC2 LINC01600 RBX1 SRP9 PYHIN1 NCSTN CDR1ST6GAL1 HLA-A PYROXD1 NO_MATCH_10 SMTNL2 SH3YL1 COL9A3 ABHD18 NNMTNO_MATCH_65 CAV1 PDLIM4 FCRLA WNT1 IZUMO1 GREM2 IGSF6 CDK5 TSPAN12C21orf2 NO_MATCH_253 AVPR1A STK32C CLK3 XLOC_I2_008285 AK3 NUP62 PLEKHG7AEBP2 PREB TMEM231 ARL10 EIF5 CNPY2 MRGPRD USP6 NPAS1 TNFRSF14 HSD17B3LHFPL1 OR5P2 SVOPL PEPD BEND6 ACKR1 SAA2 MRPS22 LRRC8D C15orf32 PHLDB1FAM204A CLK1 CFAP47 CNPPD1 FAM127B PTPRR CD207 LINC00305 TGM5 TSPAN32CGNL1 GPR171 PIKFYVE FYCO1 IFIT2 CREB1 ZC3H8 USP32 DDI2 C5orf46 FSD2LTB4R HGF Pin4 H2AFY2 TDGF1 SLC25A51 ZFP28 C1orf112 PIEZO1 ITGB3BP SSTR5SYPL2 DUS2 DDX55 PREPL PUS7 PDILT NUSAP1 MKNK2 RAB11FIP2 TRAP1 C6orf203SCAMP4 HGF TCF4 PTP4A1 MAD2L1 BEX2 NO_MATCH_137 MYF6 FAM167A ACER1 ACTG1STRADB PLB1 TMED10 NO_MATCH_130 RPUSD3 LURAP1 NXNL1 UBE2G1 TERF1 OVGP1IL1A TRIML1 NECTIN4 UCHL5 TMEM129 CER1 ETV4 RABL3 GRIN2A HMGCS2 SLC25A35MRPL37 ZDHHC7 FAM46C GTF2A1 MIPEP ATP6V1D TMOD2 CSNK1G1 SRSF11 RPS6RABEPK BCAS1 STK40 NUDT10 LILRB4 ACSS3 NAT8B HCLS1 LRRIQ3 FAM69A MMD2PRPS1 JAK2 CELF3 RPS27L LZIC TAS2R42 RELT LGALS8 SUCLG1 RAB42 IMPACTRPL23 ENPP7 DUSP18 FAM49B TGFB3 BCHE PIP5K1A ARMT1 FOXN3-AS2 ST8SIA1ANKRD36BP1 TCEAL3 BDKRB1 HEY1 B9D1 RIMS2 KCMF1 C19orf43 DCAKD GPR20ATP6V0C ID2 ISCU TMEM155 TBATA MFSD1 CEBPG TOLLIP LFNG CSNK1D AUP1PHOSPHO1 RAE1 TMEM234 NIFK GPRC5D ZFAND5 ERP27 DOC2A GOLGA8EP SNRNP40IL21R TMEM25 TEC NME1 OLR1 MYOF FBXW12 HHATL SMCP TGFBRAP1 C18orf21Zyg11b NO_MATCH_29 ARL6 PARP3 RFK SF3B4 PLPP1 CXADR NO_MATCH_57 FTH1ZDHHC9 BCL2L15 SKAP1 ATG9B XLOC_013207 BCKDK TMEM72 GRK6 NACA2 PROSER2CKB LINC00486 RPL24 PSMD3 GPATCH11 SLC2A1 AK1 PCSK9 DDX18 LEXM EPHA4APBA3 PRSS50 DRD5 ZCCHC7 FAM19A3 NOSIP PLEKHJ1 Cdk11b VPREB3 OR52B2HOXB1 CMA1 SCG2 ERMAP ADCK2 NO_MATCH_85 TTI2 POLR3D FSHR MMP12 SERPINB5TMED4 CCDC66 M1AP ZNF526 KIAA0753 BBS9 NO_MATCH_60 C17orf62 P2RX4LOC100289561 ANKRD34B MAGED4B ACTR3B OR2S2 TPBG RWDD3 C11orf71 UQCRC2TRIM42 NR0B2 IGLL1 MRPL17 PRR14 HIST1H3E PROCA1 PDGFRA LANCL3 TXNDC12CST8 CTDNEP1 GAL3ST3 PRPS1 SUV39H2 NIPSNAP3B TNFRSF11B CTBP2 GDNF MRPL1STK40 BOD1L1 CDH5 LYNX1 ARCN1 PSME2 TAS2R38 MAPK3 FASTK PTGER4 Grid1PCBP3 RPL21 IQCH NUAK2 GNB1 MTRF1 TOPBP1 RCAN2 RASGEF1B RPS6KC1 SMARCD3SGK2 TMEM62 TMEM255B MROH8 GPR143 POLR2E HCAR2 MAPK10 RET ZBTB44 SLC19A2GJB5 MDFI PTBP2 HLA-A MRAS C11orf45 PRKAB2 SEMA4D SETBP1 PDGFB CCDC9AKAP13 UBE2DNL 42984 PDXK GPR35 ADIRF ACOT4 RPS27 CAMK4 MGC16025 KLRG2MAP2K2 OR10G8 STRADB FUT1 DUSP12 KLK5 MAPT AIMP1 FSTL4 TMEM30A AGBL2UTP15 CLEC4C HIST2H2AA3 VTCN1 COX16 CST6 RIC3 SPEM1 SIX1 RPS28 ST3GAL1PLA2G7 RELL2 SERTM1 RAG2 SNAPC3 MNS1 DNPH1 CCDC74A NOG CA11 IL12RB1AIMP2 CLN8 NAT1 TOMM40L HIST2H2BF SPDYE11 TNFRSF9 RPLP0 SPPL2B MAP2K2LONRF1 TMPRSS12 METTL2A BCL2L14 C16orf74 YY1AP1 CHCHD2 TMEM164 MPP6ATMIN RGP1 DNAJC30 C15orf40 RUSC1-AS1 CHST5 PBRM1 Mbd5 EXO5 RORCHIST1H4H FAM64A ARL11 STX19 XLOC_I2_006862 CDK10 FGFBP2 DEFB104A NLGN3GIMAP6 ZNF148 PDXDC1 KLHDC2 SNAPC3 ALDOA CABP5 DGKE MMP13 ZNF543 YBEYCHRNB2 GDPD5 TRMT61A SEPHS1 BRE TMCO2 DCDC2B OGT GMCL1 SAT2 TSSK4 CALM2UBXN10 ELOVL7 CLEC4A BORCS8 LGALS3 CELA2A ALKBH2 DEXI FGR SLC22A2 NPIPA1RNF10 GTPBP3 FLT4 TWISTNB LHX8 PPARG ZXDC RNASE13 VASH2 NO_MATCH_166CDK20 GRM2 POLR3K OR4D1 QRFP CSNK2A2 FBP1 MRPS12 EIF2S1 LMBR1L DCTN3FURIN C7orf43 NO_MATCH_183 SRP68 LOC440700 SLC10A1 AGTR1 SLC22A7 SIGMAR1P2RY13 SLC41A3 NCALD PCP2 PRSS2 SLCO4A1 PANK1 RAD54B CELF4 DPP10 CFLARFUBP3 CISD1 GALR1 TIMM8A PIGK CFAP45 MSLN BRI3 CHCHD10 ASCC2 PDK4C1orf131 C1QTNF3 CEP135 P2RY12 SMIM2 UPP1 GPRC5D SIGLECL1 CLHC1 OCIAD2SGTB PRG2 C9orf139 MUC1 FAM122C ACOT1 AK4 ZNF581 METTL9 LNX1 TDRD10CCP110 ZNF80 PI4K2B KLHL15 HSD11B1 PLA2G3 PPAN CENPO NAA60 CD300E RTN4RGTF2IRD2B BTBD1 HNRNPDL IGLL5 MAP2K2 TMEM123 C22orf31 PRKCH AKR1B10 KDF1TMEM35B DGUOK SAE1 SAMD11 ZSCAN2 NO_MATCH_46 RPL13A SLC9B1 ATF2 FOXRED2RASSF2 HIST1H2AM BMPR2 ASB6 LY6K HIST1H3F HSD17B10 E2F6 PDK1 FAM110DHLA-DMA NAP1L5 PTGES3 B4GALT3 XLOC_004271 PTGES SPTSSA TPM1 GFAP CNRIP1RAD51 MBLAC2 C11orf54 KCTD1 MAZ UBL4B CYSLTR2 KIAA0141 PTK6 MVD ARAFZFHX3 SUDS3 ZHX1-C8orf76 ZNF644 PPIA EIF4A1 NO_MATCH_201 NO_MATCH_87PHKG2 TMEM189 RRP7A PDE1A VEPH1 TMEM106B AIRE MRPS6 LOC641367 RHOF ROPN1THRA CLDND2 SLC17A4 Cpsf3l P2RY13 RGCC SERPINB5 MFN1 LOC105372824 OR2T33GALNT9 PCDHB4 CCL2 PRKCI HIST1H4C RPS17 DMRTB1 C11orf70 SPACA3 LGALS3BPNSMCE4A HECTD3 PARP11 TP53BP1 BLK MLC1 CAMK2A LGALS7B CNTF CCDC84 KLK15SUPT3H ANGPTL3 TMEM82 MOB3C RNF183 KRIT1 TCF23 SCTR KRTAP19-1 IKZF2CELA2A HMG20B GRIK2 SCYL1 PSG2 PRR3 STK19 HLA-DRB1 PPP2R5C CLEC12A GLRX3RNH1 CXCR3 SNAP29 DGAT2 MZB1 LGI2 CD274 DOK1 NPEPPS ZMAT3 ZKSCAN4CLEC11A UBE2T TUBA3D HAGH GPSM3 NECAB1 KRT81 PEX2 PARPBP LINC01588 KMT5ANAXE TESK2 LIN52 MTHFS HYOU1 SKA3 C5orf38 WNK1 RPL14 ITGA6 CATIP NOXRED1GABRG2 PRR11 IL36B GJB3 MGLL OR2A12 NO_MATCH_190 CERS3 ZIM3 CCNJ MAP4K4EXOSC7 SYS1 LSM6 OR7A5 PTH1R FAM58A TAS2R19 SCEL CXCR1 NPL MOS BMF SRP14SREK1IP1 CRISP3 TMX1 CAMKK1 GSTA4 RDX RPE DKK4 EIF3I TM2D3 NOVA1 OR10A2KCNJ11 MC5R CCKAR B3GAT3 DACH2 FRMD3 DRD5 BSCL2 TUBGCP3 TMEM88 RIPK2GDPD2 SSBP4 XLOC_001866 KRT15 ACSF3 IFNA17 LINC01260 PACSIN3 MCM7XLOC_I2_005978 HIST1H1E FGGY MOB1B LRRC15 ADGRG1 METTL15 FXN GPR18 CREB3KRT71 APLN NO_MATCH_187 GPATCH4 SEC63 DFNA5 LDLRAD1 PCDHB10 TMED5KIR2DS4 ADIPOR1 IQUB C1orf54 CDK6 GCM2 LGALS4 LOC442132 GGTLC2 LIG3 RPL9ANAPC5 MAPK14 CCR7 FUT9 FSBP EXOC8 NO_MATCH_48 TLDC2 USP18 NSUN5 EPN1ANKRD13D OR14I1 TADA2A C3orf14 PRAMEF5 TAAR9 MCTS1 CST8 COX14 ADGRE2ETV5 DDR1 STARD7 AP1S3 TBK1 TAC3 MTHFD2L MAGT1 GGA2 MYCT1 EXOC5 ZFYVE27PSMD14 RPS16 GPR52 MAPK14 VPS52 CST2 TPM3 AGA F2RL2 FKBP14 RADIL P3H4EIF1AY PLIN2 RGR ANAPC11 EAPP ECI2 THAP6 EEF1D EGFR RAB17 RXFP2 SNN LGI3G3BP1 TREML4 PDIK1L HEYL UAP1 ILK SYCN FHL1 C17orf97 TMEM67 ACSBG1SLCO4A1-AS1 ARL17A PUSL1 CRHR2 IGF2 LIPC MUC1 USP32 MTHFD1L BBS5 ADGRF1LOC440570 EVA1B DDX39A FAM214B RGS22 CYP4F2 CST4 CRYZL1 AGBL4 STMN4C2orf68 MT1E DDX28 GLT1D1 PCED1B IL10RA DBNDD1 CD80 ATP1A3 MAN1B1TBC1D3J ZDHHC2 DDX50 TRIM29 ZMYND19 ILK SALL2 CYP2C9 HARS2 MAGEB2 FOSTMSB4XP8 ZNF621 PSMB5 DRG1 MET FGFRL1 TMEM70 FCGR3A CPVL PAQR8 BEX5 PF4MSRA GPR20 IPO5 PRKACA SERHL2 KIAA2013 PSMA6 CHCHD7 TFAP4 MOB1A NR1I3CALCB JPH1 LCP1 UBE2R2 TNFSF12 MLKL NMRK2 EGFR NO_MATCH_95 MAGEA5 PLLPTWISTNB ARHGAP5 UGT2B4 EIF2AK3 OPALIN CYSTM1 ZNF384 FGB CSHL1 DXO HP1BP3RUNDC3B ULK3 MUC20 PADI3 SLC6A3 ALOX15 TDRD3 MET CHCHD6 INTU SNAI3ALKBH8 OR3A1 SLC2A3 RIC3 KHDRBS2 SCG3 LZTS2 GPR34 SLCO1B1 Rictor DUSP1DGUOK C7orf49 FBXO48 KRTAP19-7 SIAE MRGPRG PGR AKR1C1 FBXL21 SLC25A36UBE2Q1 TESK2 HTR5A ZKSCAN3 VAMP4 GNAL ZFYVE9 MAPT IL23R MTPAP RNF32IKBIP P2RY11 SAMD10 HACD2 LY6G6D SH2B3 CACNG3 SIRT6 SUCNR1 HPRT1SERPINA3 HDAC11 ADAM30 EMSY CPSF4 CARD11 FLT1 CHD9 LRRC40 KCNJ10 GABBR1FAM168A PHYHD1 MRGPRX4 PCGF6 PCNX4 ZNRF1 ACKR4 TNNT3 SARNP RPL17 ADGRL1DNASE1L1 LRRC20 ACBD6 CLDND1 PPP2R3C DLEU7 DTD1 ARAF LYZL1 TK1 RNF170CRB3 RAB33A OR2T10 LY86 COG6 SRR LYPD2 OR2T27 RPS18 MTMR7 DENND2C HIPK1FBXO22 PARK2 NEUROG1 CD72 U2AF1 A1CF BET1 NEK2 SREK1 MBTPS1 TBCA GRK3FAM57A PPP4R3A TTC6 HRH4 OGN TUBAL3 GLTP TMC5 USB1 DVL3 SMU1 SLC23A1RPSA STK32C SULF2 NDUFB6 FGFR1 MTIF3 LCN1 TBC1D9 FCGR2A ZG16B LIPH CHRM3FBXL8 THEG NO_MATCH_272 UBE2Z TRDMT1 RGS20 DYNLL1 SEMA4F GSG1 ERCC6L2SEMA6C COPRS DEFB128 CCNY CAMKV TTC5 LMO2 OR2B2 HBZ VWA3B LRRC37A5PRNF19A FAM153A PRKAB2 NRBP1 C5orf60 VPS37B DPYSL2 NSUN5 LCK GLB1L2XLOC_011297 CD70 PDIK1L ALDOC RACGAP1 SERINC2 ZNF287 ZNF19 CLDN20ANAPC16 ISCA2 ABHD14A COL8A2 ABCB5 SCAP FAM92B KRT222 MFSD10 EDNRBTCP11L1 RPL13AP17 GPR151 ISG20 RSL1D1 FAM222B NIN RPGRIP1 SHARPIN RUNDC1CFAP161 WDR60 ABHD14B NO_MATCH_58 MID1IP1 CCNH PPIA RRP8 NO_MATCH_213NDUFB3 PRKACA KCNC1 ICE2 SMPD1 TNIK UCP1 LINC01547 BTBD6 FGFR3 RHOT2CALM3 GPR87 EGFR KRTAP10-11 DIO1 PLA2G2A LOXL2 OXTR ADRM1 MRPL45 MEAF6ZBTB49 FMC1 XLOC_I2_009136 GPR52 RNF114 STK17B RXRG HEATR9 NUMA1 CHRM5STK16 CDKN2D CUTA GNG3 C1QL4 TMEM169 PON1 NR4A1 GRM8 CHD1 RIOK1 PRKAA1HBG1 RNASEH2B MVB12A SLC25A27 ERBB3 COPZ1 FGGY TBC1D26 FOXP3 HPXMAPK8IP3 WDFY1 KPNA2 NAT14 KLHDC1 PTPN9 LACRT PDRG1 KRT8 PRICKLE4 PBKCSRP3 NYX SLC25A10 COMT ZFYVE19 TNFSF13 ASPM ADCK2 WASL TMEM39B EGFRKHNYN NO_MATCH_141 PLA2G10 UCHL1 DEFA4 CCL7 Kdr C10orf71 BMX MCHR2SPATA8 ABCC4 CT45A10 KLK3 NO_MATCH_26 SMNDC1 SUPT5H TAAR2 F2RL1 APOBEC3GTH ANXA2 KLK7 CDC42SE2 SLC2A5 POLR2K LIPE BOC C18orf25 NMUR2 KRTAP26-1AP4E1 AHDC1 CIB4 TBC1D28 TLDC1 MGST3 CCDC57 RAB39A NPR2 TAF8 GUK1 IFT80UCK2 ATP6V0C KCTD17 CIPC PI3 EREG CNR1 ABHD4 PARP6 ST3GAL2 PRPS2 HSPBAP1TMEM86A METTL13 NO_MATCH_161 SNX3 FXN SNRPF CAMKK2 ZNF223 OR1D4 CPXCR1MGST1 SAMD7 SLC2A6 CAPNS2 STAG3L2 RPL26L1 ZIC3 AKIP1 MGC34796 TCEAL4FZD4 LRRC10 SGK494 AMY2B CRYBB1 IDO2 PROK2 C22orf46 KCNH1 CCDC83 ATP1A4ADGRD2 CC2D1B SPATS2 CCR7 FLJ13224 UQCRFS1 GSTP1 GLUD1 RLN2 BRK1 CHIC1AADAT PRSS2 ALG6 DDAH1 GNB3 USP49 GRINA KIF14 ASL DZANK1 PSD4 INPP4BTRIB1 ADAMTSL1 SLC45A2 SRD5A3 RPS4X ZNF550 Olfr981 CLRN3 Dolpp1XLOC_007690 RITA1 ADORA2A SYTL2 ACVRL1 NPM2 ILK PCDHB15 CXorf57 SLC6A1NO_MATCH_5 OLFML3 CCL15 SLC13A5 FAM175B CDCA4 B4GALT7 FAM96A TTC39CELOA3B DOLK PGLYRP1 TLX3 JAML TTC39B MS4A1 FAM163A NOP16 AVPI1 NUDT2ALS2CR11 CT55 LYSMD2 NT5C EGFR MRPL10 RSPO1 ZC3H3 MICU2 CCNG1NO_MATCH_63 LEMD1 NT5DC2 OR13C5 CFAP77 NO_MATCH_281 OR52N4 MRPL10NO_MATCH_160 ZNF474 PRELID1 CLDN9 C22orf23 RPL26 TMSB4X HES6 LRRC55 RRM1RASSF4 ERCC2 RGS2 TMEM230 MRGPRX2 STK17B MFAP3L GDAP2 SF3B3 PSMC1 NDUFB6IFNA7 KIAA0232 LSM4 SLCO1B1 ZNF346 THEM4 IGFBP6 C14orf105 HRH4 HSD3B2MOCS3 MSMO1 TXNRD2 SLC5A9 LBX2-AS1 FXYD3 NAGPA FKBPL IFI30 MYL12ALOC105371303 SMIM5 RSPH14 NO_MATCH_82 PAPD7 TAS2R20 NSDHL LSM14B MRPL16ISG20 ACVR1B MILR1 COL9A1 MPPE1 BRIP1 BRICD5 SYNE4 PRKAB1 TAS2R60 DDX21MAF1 HIST1H4G EEF2K CHCHD3 SLC5A2 DTL RAB28 TTC9B TP53RK NO_MATCH_140APBB3 ADGRF1 DPM3 UQCRH QTRT1 MRGPRE CNPY1 TCF19 TRMT11 NSUN5 CSNK2A2SGCZ PRKCI CDC42EP4 LHFPL3 PRAC1 HYAL3 CFAP46 PGR NT5C SULT1C4 OSTNATP5F1 SH2B1 LOC107984064 XLOC_I2_000915 SLC9A8 ZNF519 SLC41A3 PON2TMEM81 C9orf116 CXCL14 PKLR FAM71E1 RHAG XLOC_012148 PSMA5 EFCAB3 SPTLC2EBLN2 CER1 PDZD9 GLT8D1 TMEM216 GRM5 MLH3 SHISA5 FCRL2 XLOC_010007 USP29GCC2 GOLGA7 HAX1 WBP1 PEX11A NO_MATCH_219 LIMS1 CETN3 TSSK1B ARHGAP45PRMT2 ACTA2 C17orf49 KIT DRD3 LXN RMND5A NDEL1 OTOR SNRPD1 TSPAN10 CWC15MYZAP SLC25A48 FERMT2 F11R XLOC_I2_001972 LOC107984344 TMEM220 PEX7CDKL3 CASC4 RBFOX2 SPPL2B PIK3CA DPPA2 SORCS1 ZCCHC11 DSCR8 CCR1 BCAR3SWT1 RBL1 42796 ISYNA1 ZNF26 NO_MATCH_241 CXorf57 PPP2R5D VCPLOC107984065 ST8SIA2 TUBA3FP SIGLEC5 KDR SLC4A2 LAIR1 HIST1H3G ACBD7PF4V1 ITM2A GCM1 DNAJC14 NCLN NEU1 ADI1 ECEL1P2 HIST1H2AC ACP5 UBE2IMSRB2 MAGEC2 CATSPERB RBM25 RPL18 BMT2 DGKE B2M Eri3 HNRNPF SPATA19ADAT3 VPS26A PRKRA DTD1 CCDC110 GPR155 PAPOLB RNLS DICER1 DCUN1D1 TMX2CCL17 PLXNA2 GPR174 SEC16B CD164L2 NMNAT2 LCN15 NDUFAF8 KANK1 LIPARBFOX1 GRM7 C14orf177 NSL1 HTR3D CYP19A1 IL31 VPS41 GPR52 C11orf65 EDNRAPHACTR1 STK19 GPR27 HAT1 MOS PTPRO AXDND1 MPST ZNF385C LRPPRC EIF2AK4TNKS2 LOC105369201 PRKCH ERBB3 SLC2A4 TEAD4 DYRK2 MYO1F ALDH1A2 ZNF462CX3CR1 TMEM170A GAL3ST1 LCN8 NTRK1 SIRT6 PNKD CSNK1G2 CCDC158 GALNT1C11orf53 ANKS1B RNF185 NO_MATCH_227 SLC8B1 RPS4X AGTRAP UPP2 ADGRF3COX7A2 AURKC FIGNL1 IL21R CLEC2D TESK2 HLA-DOA ZDHHC11 CST9 TECR LPGAT1SHISA2 TTC33 DNAJC4 NR1I3 TAS2R41 RAD54L2 Akt1s1 OLR1 ADGRG7 JUNBXLOC_003758 CDC42EP3 CHAD PFN2 CPSF4L ADRA2C TMEM40 NEK5 FCGR2B SGK494ANKAR KIF26A CFHR4 CBY1 MAPT TSC22D4 VCAN JAG1 DLX1 TMEM55A TRIM27 INSRRZNF207 NADK2 AIMP2 RPS6 ACVRL1 GPR63 FASTKD3 CUL3 GPR68 PRKAB1 NPY6RGPR173 BCAP29 PRSS38 MKNK2 NANS NDST3 CLCN2 PRPF4B CDC42EP4 OTOA AGRNCDH26 RAB39A EFCC1 CKAP2 RAB20 TMEM267 CKS1B FAM71F1 TNNI2 TMEM126BPAPD7 GRM1 PRPF4B IPPK SWSAP1 LNX2 DHX8 CD69 NDUFV3 ELOVL7 PPY STRNRAB9A DLD BSPRY UEVLD CYTH4 ZDHHC1 NO_MATCH_7 PI4K2B TRIM39 ALG8 RBM15BKIT GRIN2A CALM3 TBXAS1 RBP3 HOXC8 NGEF SLFN5 DAP LUZP2 MAPK12 CLSPNGPR155 ARHGAP12 CER1 FAM71A S100A8 KIAA1143 IL10RB RPL13 CYP3A4 CENPSGMFG ECE2 NO_MATCH_23 FASTK CTNNBIP1 SDR9C7 AFF2 PIGN ATAD3C CYP1B1 SAA1DTWD1 TSSC1 FAM104B HIST1H1T CDK9 PHTF2 SERPING1 YPEL3 NO_MATCH_198Ccdc28a NMT1 PCYOX1L MOXD1 RETNLB ART4 PNO1 LIMK1 RHO AURKAIP1 MRPS27IL1RAP ZNF431 Bloc1s1 FLJ44635 NOTCH1 AMMECR1L TMEM185A TBK1 FARP2MRGPRF ARMC12 TLCD1 TMCO3 RGMA PLAC1 FBXO6 DSN1 CLEC4M ALS2CR12 HMG20BNPR1 RFESD EPHA2 CDK1 INPP1 ANAPC5 F2R ZNF616 CFAP47 MEPCE FGF12 PIK3R4DIS3 PARS2 NO_MATCH_274 OIT3 MRPL11 GAD1 ADGRE1 STK24 ECSCR CACNA2D4GNLY TIMM21 SDHB HSPA14 GAR1 ADGRB1 ZNF615 CYP27A1 SPANXC FAAP20 DAPK1MERTK BTRC TRUB2 DDI1 CD200 FABP9 CNDP2 AK1 LCOR P2RX1 GRM1 NXPH1 CLCC1CCDC110 NOTCH3 SLC38A4 KLHDC9 VSNL1 Ttyh1 POGZ COQ8A EPHX3 GPR21 UBAP2LPSG11 STXBP6 ASS1 SSR4P1 SCAF8 CAMK2A PNLIP PAQR8 ERBB4 PTK2 MS4A2 EXD3OR5F1 HHEX EIF4H TM7SF3 MATK USP15 PCP4L1 SYT16 SERPINA1 BCKDK CACNA2D3SLC35E3 SLC22A9 CASP3 COA7 EMIDI PRSS22 GLYATL1 ARHGEF2 AHNAK2 MEA1TTBK2 MESDC1 DZIP3 NME3 OPRM1 GCHFR MPZL2 POLR3GL KCNA1 OR8B4 PCNA LIN7CNHLRC2 PSMB3 LHPP NCS1 CNTNAP3 ZNF575 NXF3 GNB5 STK26 XLOC_I2_005718RUVBL2 C16orf70 MOGAT2 ALKBH7 COX6A2 POU2F2 CLCN6 KLK12 DNTTIP2 COX18TALDO1 SNX20 HSPBP1 PRPF4B SLX4 CCL24 REPIN1 ANTXR1 RANGRF EXOSC4 BBS1CHMP3 CD28 CAMKMT SPTLC1 CHRNA1 TXNDC15 PLCB2 OR13C3 INTU CYSLTR1 LYPD2NPDC1 CD3E CA8 IGFL3 ACKR4 GPRIN1 RTP2 CYP1A1 PPFIA1 ZNF595 OR52B4ADGRA1 INTS6 HK1 NO_MATCH_200 TNFAIP8L3 CDK10 COA5 FAM118A RNF166DEFB106A TLR10 KRTAP23-1 KIF6 RPL23A CDK5 ASPHD2 CYB5R1 PHLDB1 SEMA4GTSPAN17 CDK15 OR2D3 WDPCP NAV1 SPO11 C9orf85 FGFR2 HERC4 JAK2 FGL2KIAA1161 ZNF789 NO_MATCH_226 SLCO1C1 PFKFB3 ABL1 ETFDH SC5D FUCA1TRMT10C DUSP18 ANXA11 IRF3 HACL1 REG3G KDELR1 NIPAL3 S1PR3 ZNF30 CLDN2NINL CERS3 DXO OGFOD2 BCL2L10 OLA1 PDCD1LG2 NFATC2IP ACVR2B HINT2 MCF2LBANF2 AREG XLOC_I2_007111 MEN1 SLITRK3 ACYP1 PADI3 DHX33 C11orf16 USPL1PIK3CA TFR2 TMED3 DTYMK TRPC7 RAB40A TPM4 KIR3DL2 CD160 SENP5 TRMT13TSPY1 RPS6KC1 CYYR1 TSLP COPS6 SEC61A2 DLG3 IL17B NO_MATCH_208 ALPK2FZD6 FAM189A2 ZEB1 CSAD PLP1 HMGB2 ASAP3 AMY2B C17orf75 ZBTB20 SFXN2UPP1 MFSD13A IL33 ERI2 CSPP1 USP42 MRPL23 HLA-DMB UCN3 RAD1 CEP72 BTBD16CCDC59 RMI1 PRR13 42988 RTN4 TRMT10B XRRA1 RRP1 INPP5J MRPL41 TARSL2 PTSSLC39A2 KCNV2 NPC2 FGL1 CHRNA6 VDR CACNG7 ZACN NHP2 NLRP10 IPPK NKPD1SCRN3 WDR83OS MYLK MSH2 XLOC_009142 TMEM11 PANK1 TMEM222 CSNK1A1L TPP2NRF1 HAUS8 PRDX3 TAS2R41 NAPRT PIH1D2 PUS7L MAF1 VAPB DDB1 MEGF10 NCOA3TSC22D4 BPIFB2 LYSMD4 AFAP1 ARMCX5 ZC3H10 ANO6 FKBP9 VAMP1 ATG4D MMP10EFNA4 HTR3D EIF2B2 HIST1H2BM TPPP2 OR4N4 UBE2Q2 SPZ1 ACTL6B TAAR5 COASYREEP5 FAM20A NO_MATCH_11 MAP2K2 HIST1H2AA HIST3H2A PRB3 DYRK4 MAP3K5NPIPB9 RARRES2 HHEX CCDC150 AVPR1B TSC2 SMARCA5 GSTT1 ACVR1CLOC102725035 GPR137B FBXO44 NEK3 UHMK1 COL23A1 NUMB SPATA31E1 LY9 Fam76bEGFR C11orf65 LRRC29 SNRNP27 CHMP6 MACC1 SV2B RBMS3 RXRB CLIC5 MIA2ATP23 IQCH LOC149950 NRIP3 BLCAP HSP90AA1 USP25 HSP90B1 SPAG11B OSBPL8FGFR3 LIMK2 C2orf48 NME1 ANKRD26 KDELC1 DDIAS CA14 ERCC5 STOML3 TMEM165PIK3CA FPGT CCRL2 NBPF9 DCAF12L2 FFAR4 DTX2 KCNJ10 NICN1 MRPS24 ALPK1IGF1R MCOLN3 KIAA0922 STAM KLHL9 TTLL4 NTNG1 ACSL3 SLC48A1 ZNF263KRTAP19-5 MEIS2 DUSP6 TIMM10 MPZL2 KRTAP10-3 YPEL4 OPN5 CD8A TSPYL1 CCNCKDR EPHA3 CNBP CCL4 INO80E HPS5 ITLN1 SLC25A39 RTN4IP1 TNFRSF9 GPR15NOL6 PRKAR2B ZGRF1 42982 LCOR KRT26 ANKRD27 TSTD2 ZNF260 FAM19A4 SSSCA1ZNF738 KCNJ14 CASP1 GGT2 TAS2R9 ANXA2 SLC35G5 MAFB LINC00895 FAM208ADNAI2 SORCS3 OR6T1 FAM135B ULK2 NHLH2 GPR173 CCDC42 HIST1H4A ZNF610TOB2P1 SBSPON ADCY9 ADGRA1 IMPDH1 NCOA3 GNAZ XPO6 AHSA2 MIR31HG RPSALRRC10 ZNF473 PCDHB1 PIH1D3 LITAF LINC01105 YIPF4 NRN1 RPS6KB1 LATS1PDZD4 MAP4K2 NRSN1 PEX11G XLOC_I2_004840 CRYAB ZNF574 OR11H12 SHMT2 MPP5TPK1 HRH3 Fbrs ANXA2R MTHFD1L ALPP HOMER2 KLF7 STT3A HRH2 PNCK ATF7IP2OR1S2 PDE3B KCTD21-AS1 IFT80 AQP7P5 HSPH1 RBM15 MET LIPC Cdk13 TMEM168KISS1R PON1 42803 LHFPL1 TSPY26P NUP155 KCTD17 PNMA5 TMEM214 UPP2TBC1D10B GPR65 WEE2-AS1 HDAC10 GYS1 THY1 ACLY SPIN4 MC3R RBM10 FBXO38C9orf24 PCSK1 CORO1B LATS2 B3GALT5-AS1 CACNG1 TM2D1 ADGRB3 TMC6 ABCC3TRIM74 C1QA LIN37 HNRNPU LRR1 DLGAP2 DYNC1I2 MCM2 TEX11 TBRG1 PNMT CCL13DAZAP1 SLAMF1 PHYHIPL BAGE2 UNC45A MMRN1 RXFP1 IARS2 TRAPPC8 CUL4B UPK1ASTARD5 PITHD1 ABHD12B LRRK1 SCMH1 GSTCD CUL2 OGFR LGR5 SLC37A3 CENPPDNAJC4 TPK1 PER1 MAPK4 EML1 KIFC2 TUBA3E FAM171A2 XLOC_006950NO_MATCH_22 TM4SF18 TNFAIP8 DDR1 PDSS1 XKR8 OR2A7 AK2 HPF1 C1D CDK20ERLIN2 HYDIN CGB8 CXCR6 MBIP GAGE2E B3GALT1 CD99L2 RASSF8 NANOS3 ATPIF1MAP3K13 NUAK2 PIK3R4 AGFG1 OR10H3 RBP4 ZNF839 AOAH PTAFR ZNF16 WWP2 GAB2EMC1 MAPKAPK5 NAA50 DDX6 CDK10 S100B TNNI3K TIMM50 ADAMTS5 LRRIQ3SLCO1B3 LCE2A RPS26 OXR1 VCX3A ADGRG6 SLC35D2 HSPA2 LIMS2 ZSCAN29 RIOK3COL18A1-AS1 FHL2 GPR101 TMEFF1 MDM4 RNF38 LRFN5 SLC16A10 EXOC6XLOC_I2_015133 HACL1 TRIM37 PNPLA8 YTHDC1 OR1A1 RNF126 BANF1 KLHL32MIR17HG CRH IL11 PHC2 CPA1 AMY2A KRTAP9-6 CKAP5 MTO1 CMAHP IFITM1 CHMP5C11orf49 CASP8 ALKBH3 HSPA2 AGTR1 DNAJB14 A2M ADGRD2 PLCB2 HRAS SKP2PGPEP1 EPHB1 CLDN17 ZNF512B ADORA3 C19orf12 IFNE RPRM DNAJC10 MEOX1AVPR2 TMEM56 LYPD1 HIPK3 CCDC54 PVRIG NOD1 TSR1 PDZD8 GABBR2 PTP4A3RPL7L1 CLEC19A FGF19 MS4A6A ZFPM2 HTR2B SPICE1 ZP1 HINT1 TMEM19 TMEM102SUZ12 CKB LPAR5 DGKG DUS1L SLC22A16 GPR141 HERC3 ZNF41 CCDC170 TLR1KRTAP3-2 ERGIC1 NO_MATCH_35 HLA-C METTL4 ZNF317 UFSP1 OR52B4 C1orf189ADIG TRIM10 HTATSF1 NO_MATCH_74 SNX16 PFKFB3 INSR HK3 ADGRG3 SEL1L3CELF6 DES PTRHD1 PI4KA ZNF782 GYS2 IFITM2 SLC4A5 RTP5 TPPP PLPP4NO_MATCH_43 BCO1 CUEDC1 ANKHD1 IDI1 ZCCHC14 HIF1A NDUFAF7 CBS RSBN1LZWINT PSMD12 ADAM18 PIK3CA C3orf36 SLC25A16 XKRX RPSA KCNH7 MAML3 PFN4USO1 TP53AIP1 ZNF804B WNK1 GPR85 TBXA2R TNNI3 ZNF140 GYPA AP3S2 TAS2R50ZNF280A WDR63 SIPA1L3 ERAP1 HTR1B UVSSA FAM58A CD59 MAG BMS1 MYPOPDIS3L2 INSL3 PTH2R INTS7 PIK3CB ZNF625 GPR62 IFITS CNOT11 DGUOK BLOC1S6GTPBP8 MZT1 TSPOAP1 MRPL28 PPP1R13L MYO1C COX10 TROVE2 NO_MATCH_6 MXD3IRF5 PIK3CA SSX4 TLE2 KLHL20 MCTP1 SOST SCCPDH PIGB XK PEMT CFI CHMP2AELAVL4 KANSL3 SLC13A2 RPTOR RSAD2 IDH3G RPS21 XLOC_001973 POMC CAGE1CACNG1 ADGRG7 NO_MATCH_185 EIF4E2 SPG11 FLT3 PALD1 GPR156 IDH3A WLSGPR87 GRM2 AGGF1 ATF6B DIO2 ETNK1 ARMCX5 CENPL KMT2E TMEM68 GPC1 MYO6PIK3C2G SHF KANSL1L PAQR7 SLC47A1 PRPSAP2 STARD8 MYO16 TXNDC9 PCDHGC3WBP4 REG1A PLEKHG5 ATP6V1F SLC10A1 AK3 PRSS35 ENDOV DCK ADGRG6 BCKDK RETADGRB1 KIF21B TTBK2 DNAJC10 FAM50B ZNF329 SELENOK DECR2 HDAC5 RBM12BC9orf64 KIF22 CDKN2AIPNL ZNF418 EFCAB11 DST SMYD1 GGA1 ADAM21 CDK17PDE10A FAM71B LOC100653061 PGC SLC38A11 PPP1R14D FNBP4 FEN1 MRPL50 AOC3SERPINB1 AK4 ASPDH MAP1LC3C TRMU SLC7A3 HMGB1 SETD5 DLGAP5 ZNF423 42980DHRS4 CFHR3 APBB1 PATE2 ALX1 CYP11A1 NENF LINC00174 PCDHGA9 CALML3 YIPF6PIK3CA WBSCR28 PPP1R27 C3orf52 CSNK1E ADPRHL1 PIK3CA FGFR1 PIGZ C1orf174FYB RORA CDK7 IL20RB RAB28 CLPSL1 C1QTNF9 SLC10A7 RASGRF1 PALLD DNAJC7PODN HRH3 FYN FAM135A CALCA GEMIN7 STRADB LDLR OLFML2B GDAP1L1 TBC1D2BXRN2 ASAP2 HYAL4 OR8H1 CDC34 ACOT4 ZNF8 ZNF444 TPRA1 GPR146 METNO_MATCH_211 NAA15 DDX54 AP2A2 ACTN4 CLRN1 LOC100653061 TMEM14C TAF7RPL14 PNKD GNG5 HRH1 PRRG4 PRC1 LAMTOR5 TSC1 WDR44 TLR1 TIMM17A TRMT61BATF4 ZNF680 WIFI ADGRG2 FBXW12 ESYT1 GPR18 RPL8 SLC48A1 ASPRV1 FLT3CLVS1 L3MBTL2 NANOG NEU4 MAATS1 CDON DAB2IP CLCNKB PCMT1 FRMPD2LOC107984056 SORBS3 RPGR STYX NOTCH2 PRKACG FCMR PRG3 MAOB PSAT1 RBAKPHKA2 Nalcn PIWIL2 ZNF280C PTH2R PRIM2 MST1R MLST8 NAF1 PSMB1 DGKB NR3C2VHLL RAMP1 ACAT1 BTC IL18 ZNF529 SLC46A1 TAMM41 CLK3 DHX32 OR52B2KRTAP12-2 KRT13 CDK19 SH3GLB2 CCR3 ZBTB8A NOL8 ANK1 CCDC26 JAK1 RBBP8PRKX NO_MATCH_16 BDKRB2 CPSF6 ID2 INHA CLDN18 KIF2A PDCD10 FAM171B GHSRZKSCAN5 ACVR1B APIP SEC63 ABL1 IGF1R SDF2L1 SLC20A2 FLT3 COMT PIAS2 PDK1HERC6 PPFIBP1 CFAP43 CLCN5 TTK CHEK1 SMURF1 NCAPH2 INO80 TPD52 TLK2STK31 ALG5 HIST1H3D ABCE1 RPL13A DNAJC25 IFI16 FBXO28 LOC554223 ARF3KCNMB2 BHLHB9 P2RY10 NME5 SRD5A1 IGF2BP3 CLK2 CHRNB3 L1TD1 PTGER3SLC6A14 HNRNPUL1 C11orf87 GRM3 ARHGEF35 ENPP5 PTRF DUSP26 ZNF410 CHCHD5RPLP2 FAM134B SAMD9L USP7 LOC102724159 RNF5 TAS2R9 PXDN CD80 FAM184ANTRK3 CABS1 EPS8 COL10A1 YEATS4 FAM78B FER1L6-AS1 GGN CHCHD2 LACE1 TRPM1OGFR SLC22A11 TRIM27 CAB39 COPG1 DNAJC6 RPP25 HSD17B8 RAD51B ENTPD1 AQP2BPIFA1 LIF IPO11 IFT122 KANK4 FANCB ALK NTF3 RASL10A PPP4R4 VIM C11orf72CDK8 SELENOH EPHB4 EXOG EIF3G RPL15 SEC11A KIAA1551 SLC5A9 MERTKHIST1H2AI ADGRA2 GK WDR49 XIRP2 IL36RN HTR4 CCDC97 EXT1 SOCS4 KDELR3PLCB1 RIT2 CDK1 SGSM3 NFE2L2 TMEM63C EPB41L3 ZNF83 XPR1 GTF2H2C CSKUBE3B PLEKHG2 SLC10A2 Tia1 SMARCD1 ECD TNK2 LOC284009 ZNF578 PRPF3TAS2R14 MAP7D2 TTC14 DIP2A LDLRAD4 RGL1 CSNK1G1 GHRL CCDC94 STAT3 CYB5APLCD3 TACC3 SSTR2 FLT3 PKNOX1 APOC2 QPRT DDX21 ACSM5 SEC61G DIP2C DSG4FAM107A PHF8 RTCB ADD2 TMEM241 IRAK1 PCYOX1 H2AFB1 BCKDHB CASD1 EFCAB6MCHR1 ARAP1 C22orf39 ITPKB OR1L3 CD74 PNRC2 SEC23B VTI1B ARHGEF16TMPRSS3 NISCH DPH5 CDC20 MRPL1 ERG TMEM241 KRT1 OR51F2 AKT1 JAK3 PHACTR4ELMO1 BDKRB2 SH3BP4 CNFN DIP2C HAO1 TTK ZNF816-ZNF321P ZNF114 NUP37 LIG4STK16 ATP6V0A4 MAPT BRD4 PSMC1 ZNF10 ZNF667 MPC2 LAGE3 CDC27 A1BG ULK2USP15 ANKRD18A PSMD3 IFNG CEP70 COG2 HAUS6 PCLAF Mbtd1 EPHA2 RPP40PRPF4B CALCOCO2 TAS2R60 VPS54 RND1 ASZ1 VDR MATN4 PSD2 ZNF770 GPR132PHIP RFC1 SYT16 BBS10 GSTK1 MC1R TMEM248 NXF2 LOC441242 PRPF38B PCDHA11LPAR6 PAK6 TGM4 C19orf18 GAS8-AS1 TAS2R31 DCP1A CSNK2B ADGRF5 CDC25BCDK9 SDHA PIK3CA CHEK2 C17orf82 ZNF546 KIT ADGRB2 ZNF781 ASB10 GPRC5DAK1 RFXANK SNX7 PNPT1 PRSS57 CD274 EPC1 DLGAP5 FOSL1 PCMTD2 PLRG1 SEMA4AAP5B1 COASY CSNK1D RBM26 SMARCAL1 DTYMK HEY2 CENPA NO_MATCH_256 GBAARAP3 RYBP KDM8 PROKR2 ABL1 SLC7A13 LCA5 HENMT1 CDV3 VPS33A PHF21B COPB1ELP2 MAPK9 ZNF211 RNF130 RAPGEF4 ZNF461 SLC35F3 SMIM12 CRYGB TCAF2SLC7A2 IL16 WDR66 C12orf10 ZFP2 P3H2 NOP16 MAN1C1 RPL5 ZNF511 RPS6KA3PRKAG2 ZMYM4 ADGRF5 TNFSF12 DIRAS3 EDA2R COPS5 SCNN1B AGPAT3 HSPD1 FLT3SCYL2 DPP4 KCTD3 NO_MATCH_96 UPK2 PDE7A MINK1 OMG KANSL1L BSND SLC6A15NCR3LG1 COL4A3BP EGLN3 MAPK10 RBM14 FAM134B SCGB2A2 CPSF6 WBSCR17 CENPXOR6C65 MET FBLN2 BRPF1 HDAC3 LOC642249 PLD1 NIPA2 SLC13A4 FCHO2 PRPF31MAP4K3 PSG9 CUL5 HIPK3 Dock10 KLB MED24 SLCO1A2 METTL21A NT5E OCRL CSN3LINGO1 DPPA4 RBPJ LRRK1 ZNHIT2 IL13 ALPK1 Nrbp2 PSG8 SLC6A7 APH1A GEMIN2OR56B1 CCNC SMARCC2 ZC3H12D RHOA FAM3A HSPA9 TMEM144 ALPI RNASEH2CBCL2L12 GAS8 C11orf71 ARHGAP27 EFHC2 PMPCA OASL VPS33B MOGAT3 STK33NSUN5 DHX36 UBA2 MAP10 CCDC62 NR2C1 EYS SNX22 H2AFB3 TAAR6 RAB1A HIPK4FNDC1 GMEB1 SATB2 DMRTA1 SCYL2 DDX23 LIG3 MAGI1 ATP6V1C2 CTLA4 C1QTNF9BRRH HSPA8 LRRTM3 CLK3 APRT THAP12 RASL10B PDIA3 MIOS MT1X HLA-DPA1 ELK1TRMT5 PIWIL4 IRS1 SMC1B USP54 TLK2 EIF3C KRTDAP LENG1 SPINK13 GLULSLC9A3R2 RBMS2 ZNF266 NO_MATCH_279 CALM2 SH3BGRL2 ZBTB21 KIAA1324L BATF2SESN2 LMX1B LINC00597 KRT4 DRAM1 MCM2 RAPGEF6 TPST1 ECSIT ZNF175 GAS2L1AK6 CHRNA3 PLCG2 PHKB DPH7 MCM7 OR8D4 LCLAT1 OR52L1 ADGRL4 TRIM24 SOCS5NDUFAF2 ZNF503 C7orf33 PLCG2 KRTCAP2 LATS2 CCKBR LTN1 RFC1 NR0B2 MILR1DCLRE1A NEK11 BFSP1 TPCN2 WDCP SRFBP1 OXER1 AZU1 APEX2 NME6 GRM5C21orf58 MASTL SSH2 LHX4 AMBRA1 LPAR5 CYB5R2 FLT4 TCIRG1 KIAA0895ATXN7L1 NO_MATCH_28 ZNF556 LCE3D KRTAP9-3 HAVCR2 KIF2B CCNC L2HGDH CIB2ABI3BP FGGY FGF21 Spcs2 EPHA3 CBWD1 ZMIZ2 EPHA2 PXDNL FZD6 USP8 IDECCDC66 ZBED4 TAS2R45 SLC16A4 DNASE1L3 GRIA1 TGFBR2 HMGA1 HTR2A ZNF484NO_MATCH_67 BCAT2 TAS2R4 SEZ6L2 PDE4DIP DENND2A GAS6 PPIB LYZ PZPTMEM38B E2F8 FAM149B1 App GRM8 ZNF131 MCCC1 ADGRF1 ABRACL MAS1L OXER1OR4D6 ZNF608 CDH7 VN1R2 CADPS NO_MATCH_8 HIST2H2BE FAP SLC35F6 SHKBP1NO_MATCH_123 GAN MAP3K14 PPCS LINC01554 EIF2AK3 NO_MATCH_125 COBL RIPK4FBXL4 VCX2 SNX14 CDC7 ZMYM1 LOC254896 GPRC6A MIS18BP1 FRMD8 ADGRL4 TKTL2PHOSPHO2 ZNF85 CKS2 DAPK1 SGSM2 CCDC148 STKLD1 ARG2 TRDN IL12RB2 DDR2PRPS2 UGT2B7 PROKR2 ZNF268 LGR5 BMPR2 QARS MYEOV AP3B2 BRINP3 FBXO11CSTF2T PTGER1 DMTF1 ARMCX2 MYLK NO_MATCH_240 ZNF253 SHOC2 PKDCC COL4A3BPMET TNXB RASA1 XLOC_013840 LOC100506127 RGS1 DPYSL3 NMRK1 PSMB9 RUNX1ULK4 DDX27 ELF3 SIX2 RPF2 TAS2R4 GRIA2 ZNF638 PPP1R13B S100A7 ARID5AFAM229B MIA2 LOC81691 ZNF761 STAT3 ETFBKMT FBXO8 EPM2A TTLL4 FLT3 PPARAL3MBTL4 C8orf22 RDH11 SLC28A2 BRCC3 TFCP2 GABRP RSL24D1 SLC43A3 ELP5ZNF418 FAM120A CYLC1 MEF2D DDX20 VHL ITPKA TCF25 AKR1C1 C18orf21 DKK3PSMC4 CD93 COX4I1 SLC30A1 BOLA1 ATF7IP NO_MATCH_37 SIX4 ADSSL1 APLFGPR162 ALOX15B RBP2 PART1 CDKL2 MAN2B2 FAXDC2 SLC9A6 KLC2 UBE2D2 MUM1L1CXCR2 CYSLTR2 ERBB4 SLC25A52 MADD TTK GSE1 ZNF816-ZNF321P NOA1 KCNH6CLK3 BRCA1 CEP95 ARR3 RSPH10B PITPNA C11orf1 TONSL RBKS MRPL52 ADGRB2C1orf50 EPHX2 USP4 CSF1 NO_MATCH_238 NID2 ABL1 HNRNPC SLC22A17 HIP1 UFL1PPY SLC26A2 ZFYVE16 AQP7 ANXA6 FASTKD2 RAB9B TSSK1B LTBP2 CSNK1G2 FGF3TMEM213 Zfp317 ITSN2 ZNF35 ZFP37 STH ZNF343 CORO2A TASP1 EPHA7 MAPRE2NPFFR1 SP6 EVL TLK1 TSPAN2 MYCBPAP IFNGR1 KIT WNT9B MAP4K3 MAPK14 VARSTSPAN3 MATN2 LPP UCK2 E2F7 RPS14 ITIH5 PCGF3 C11orf54 C6orf10 COQ7TMEM161B GCLC ERVV-1 PLAT ENTPD4 ITPRIP GPC3 RERGL DNMT3A GALNT8FAM160B2 HNRNPCL1 FAM71F2 ZNF311 MCM2 GLIS3 ALDH1A3 PCDHA4 DIS3L MEP1AMAGEA9 C7orf31 DEDD MCM6 NUMB OR10AG1 PARP6 ICA1 PITRM1 SNRPA1 TRIM3DPYSL3 FPR2 GPR101 NBPF15 TAP2 DLC1 CDAN1 C9 GSG2 CLCA4 RPS18 TWF2 KIF3AFAAH2 HFM1 ZNF569 EIF2AK3 MRPL44 PAEP PLK4 TMEM255A CCDC178 LRGUK TMEM92USP14 RAB2B LGR5 OR6B2 SLC20A1 SRC CC2D1B TAS2R7 SDHD JMJD1C-AS1 PLCD4WBP11 PC KIF3C TMEM39A RAB3D C21orf91 PJA1 ASMTL ANKRD20A3 LNPEP PEA15EPHA7 ACVR2A FBXL20 DSTYK LYSMD1 FAM72B RAB3IP NDUFV2 SRPK1 OR3A4PNUDT13 LPAR1 BANP NAE1 NO_MATCH_73 STX5 AVIL RNASE4 TAS2R13 SLC22A11IQCA1 MINK1 CALN1 TAF9 FGFR3 HIST1H4L RGS3 TMEM63A ZDHHC6 COX7A2LOlfr981 SNRNP25 RHEB TREML2 ZNF107 VIT ADGRA1 RSPH10B UBE3B VPS35PIP5K1B TMC7 STARD13 PDE6B POLI NCKIPSD MRGPRX1 RNF111 APEH ADRB3 NDUFA9PCK1 C9orf78 SUPV3L1 GALR2 NO_MATCH_50 STRIP1 SNRPB NFATC1 LEPROT AASDHXLOC_I2_013393 ADSSL1 TAS2R7 PCDHGB5 LIAS FAM102A KLB XRCC6 NFE2L3 FAN1TRIM11 RHOA LBR IFT27 KCNIP3 ARPC4-TTLL3 BMPR1B ACYP2 RXFP1 UCP3 EDEM3CEP162 HEXIM1 INTS10 TMEM182 S100A12 PROKR1 ZSCAN12 CARD6 GRAP2 PTTG2ORM2 NLN NPY1R C9orf3 NO_MATCH_163 TTLL4 CALCRL IQSEC1 EPB41L1 PIK3CAPIK3CA USP3 CFL1 ANXA4 NDUFAF1 SLC52A2 LRRCC1 ERAL1 PARN DGUOK OR2J2SATB1 PCDHGB1 IQGAP3 ZPBP2 ADCY2 C7 ALG11 COA6 EBAG9 FRMD5 ARHGAP5BHLHA15 ADCK5 PLCG2 DR1 LINC00242 RPS29 MST1R GTF2IRD2B WDR1 DDX11 OR8G2ZNF44 HDAC6 CPA4 PTK7 HCST EXTL3 SUMO1 KRT86 EGLN3 RBM12 PIGA DDRGK1POLR2J GPR85 GPAT4 PRDM1 NTPCR NADK2 DDX59 DUSP28 KPNA5 NME6 MCM9KIR2DL4 OGDHL CARS DCAF4 MYBPH ANGPTL1 OXSR1 ATF7 BGLAP JAKMIP1 TEKT1SLC5A7 LINC00636 ZNF532 ATP1B1 FAM160B1 SARDH ZNF85 KLHL10 LMBR1L VSTM1DYNC2LI1 PAPOLA ACAT2 BAG6 SERTAD4 ZNF267 UTP23 TCF4 VPS11 ZNF227 LRCH2VAV1 TLK2 ARMC3 GHITM EHD2 SETDB2 BRD4 NDN TM9SF3 PAK4 COASY BANK1 MLNCLCN4 ARMC1 KRTAP9-8 TPTE2 ITM2C NSUN6 OR5T1 SETX CNOT10 SPHKAP KIF12MTM1 GPR139 KRTAP10-1 PCDHA6 CLK1 LYN ITGAE FPR2 BMP2K ZFP41 MCM3 HOXD3XYLB MAPKAP1 OR14J1 OR8D1 ZC3H12B CASC4 SMPX MAP2K6 FAM111B DARS MARK4G2E3 XIAP CDK16 BLID RBM17 TMEM144 SLC38A2 SGK2 NO_MATCH_54 TMEM185APRNT LINC01567 TTC8 WDR55 AKTIP Churc1 ASGR2 PDE4B MAST1 XPO1 XPO7 MIER1BBS7 SLC52A3 ZNF184 JUP PNPLA6 VPS53 MAP2K6 RPS6KA6 SLC41A1 ZNF138CXCL10 VAMP3 LY9 HMBS WDR41 COQ9 TLK2 XPO5 RPS6KA2 NARF STK10 ZNF43SLC30A6 Thap12 KCTD9 ZNF420 ARHGEF10L TANGO2 GYPB KCNJ12 PTPRA ZNF12GNG12 SNX6 PPP2R3B GRK6 MAP3K13 ADCY4 CLEC4G HIST1H4I OR2B3 ZNF77LOC102724428 LCA5L OR52W1 TRMT1L ATP10D OR1J1 GSK3A MAP4K1 FKBP4 FSIP1OARD1 COQ3 GIMAP8 RPS6KA1 ADGRG7 ADGRB3 CKAP2L ANAPC7 DPP3 42799 ZNF846MORN5 EARS2 ARHGAP44 GPR141 RAB3GAP1 CHL1 NARFL TNC CRHR2 TLR7 PRPHARL8A ANKRD39 RUNX1-IT1 NO_MATCH_145 EXOC1 LRSAM1 ARMC7 UGT2A3 KMOPLEKHN1 BBOX1 RERG ZNF518A ABHD12B SRBD1 MT3 LPAR4 HVCN1 SKIV2L2 ALMS1P1SYPL1 IGFBP7 PTPN6 SERINC1 UCK1 SLC2A13 ACADS NME1-NME2 ECHDC3 NEK4NO_MATCH_84 CFAP65 FNDC7 KPNA2 USP26 POGK ACO1 ZNF678 BUB1 PTK7 TSPAN3SUMO3 CHGB NO_MATCH_17 SLC2A4 ABL1 CDHR2 TAS2R43 FZD2 LRRN1 GFPT2 FBXO42FAM151B PCNX2 GRM7 TSR2 AK8 TAS2R50 USP6NL CDC42SE1 DHFR2 DYRK2 HIST3H3WNK1 MSH5 RFX6 SSTR4 CTLA4 DNAJB12 PCDHA12 B4GAT1 TNFSF14 AKR1D1 EML3GRK2 PHLDB1 UIMC1 CNIH2 LGR6 PUS10 KBTBD2 STXBP3 P2RY11 EPS15 FAM234BRIOK2 SAMM50 GFM2 SERPINA9 TAS2R60 PDCD4 RUFY2 ACOT12 HDAC8 EPHB3 EGFLAMPKN3 CYP17A1 PIGO MAP7 CASK HSD17B14 KIT ZNF555 CLDN7 Med1 NEK3 EPS15L1RRS1 AFG3L2 ZNF572 BIN3 NO_MATCH_149 RBAKDN KCNIP1 EXOC2 CYP3A43 DUSP1IFIH1 SIRT2 COPA ATP6V0A2 C2orf66 LOC102724984 WNK4 CHRM2 ACVR2A SLC22A1POLR2B JAK3 EIF4E2 ZNF300 OR2K2 MRM1 RET GJD2 FTSJ1 UHMK1 C8orf59 ATRIPNO_MATCH_33 RAD21 ZNF718 PNMA3 ANO4 SLC5A2 PLA2G3 PIK3R2 PTK2B BMP1LRRTM4 SLC52A1 CACHD1 MAP3K6 F2RL2 ERBB4 PDGFRA ZNF141 SCGB1D4 CHD1LFLT4 ZNF628 TMEM187 KLK1 UGDH NO_MATCH_105 GBP1 NO_MATCH_4 GPBP1 GRK2ATP6V0A1 ZNF37A PADI4 XLOC_010017 HS6ST1 RNASEL PCDHGA2 NKRF DDR1 PRDX5XLOC_00H64 EIF4A3 PHF14 GPR149 GRM4 NADK PLEKHG3 HIST2H2AC DENND5A PRMT6RSBN1L AMPD2 USP53 CDK18 RBBP4 BAG5 YARS PKP2 FER MTMR7 DGKG CSRP1 WDR36WARS2-IT1 FSTL1 SKP2 MZF1 ANKHD1 ZNF596 BBS4 FAM3C PTPN14 DDR1 C3orf58TBL1XR1 ZNF701 MAP3K14 INSR MATK C14orf180 PHACTR3 HLA-DPB1 GTF2IRD2BFAM120A NHLRC3 PLS3 TAS2R8 ZDHHC13 CHRAC1 SLC32A1 FSHR ACVR1CNO_MATCH_71 MASTL CDK1 SYDE1 PAM16 EDNRB DPF3 RCBTB2 LINC01553 TGM3HSD17B4 GLRX3 ZNF276 MRPL19 TSEN2 ADK VANGL1 ESCO1 ACSBG2 VIPR1 ACTR1BGPS2 RTCB SLC2A3 MYDGF RPS15A PPM1F SCRN3 FAM60A BICD2 TMEM97 DCLK2RPL27 TVP23B SUN2 STXBP1 ZNF79 DRD2 RTKN POLD1 GPR62 TMEM135 Alkbh3SUMF2 HCAR3 HBS1L NO_MATCH_225 FAM105A DAZ1 CMA1 LCLAT1 PFKM CYBBCCDC189 PRSS30P LINC00521 MAPK6 STYK1 SIK3 SCLY POT1 ACOX2 TMEM156 HIPK4IST1 SLC16A11 RNF213 HELLS RAD51C MDP1 APLP1 ZFP28 HNRNPUL1 UNC93B1ZNF92 GK CNOT4 SLC12A8 ARHGAP8 MRPS35 MYLK3 OR6A2 EXOC3L4 TMEM120BDYNC1I1 HK3 PDIA3 PAAF1 PRDM7 YIPF3 ERO1A ANGPTL7 UHRF1BP1L GPR17 SPRR3CLGN ZBED5 COLEC12 RPS6KA4 SLC12A4 C20orf144 OR51Q1 PHKG1 EML1 CYB5R1TTLL12 NO_MATCH_2 SMO OS9 OS9 CPB2 OR52B2 KSR1 CNNM4 FAM126A COG7XLOC_I2_004844 HRH4 ORAI1 FABP3 SLC44A3 NO_MATCH_191 FAM32A LINC00173PIK3CG NPBWR2 RET ESYT1 NANP ZNF485 IDH2 KCTD15 P2RX5 GLRA1 CTSE ADAM2F2RL1 MECOM CCDC140 RPP14 CLDN19 TRPC3 AFM PIK3C3 PSMC3 AGPAT3 TAS2R14TPRKB ZMYM3 CAMKK1 CCDC151 ERN1 AAMDC RPH3AL MTMR9 DUOXA2 TP53RK TPM3MAST1 GLB1 UGT3A1 ATP4B EPHB6 TTBK2 METTL22 SLC9A9 UCK2 EIF5B ZCCHC12FLT3 TRAF6 ATP5A1 STAT6 HLCS CDK8 SLC2A3 TP63 BLVRA LRGUK NEDD9 RHBDF2OR9Q1 KLHDC4 KAZN C11orf98 RIN1 ATP6V1D CS DISC1 TUFT1 FCF1 GEN1 AFAP1L1HAVCR1 HS3ST2 AMPH ADGRF3 SIL1 AMACR GPCPD1 SPG21 MAPK15 EPHB1 TPRA1CARD11 SOWAHB RPA1 FANCD2 MXD1 GLP2R INHBC METAP1D LEO1 TP53INP1 OR4X2CAMKK1 SBNO1 PRKCQ OR5D18 DYNC1H1 PAPSS1 ATP5F1 LIPM ULK3 DMD SPECC1LIMPA1 GTSF1L PAK3 OSGEPL1 MAP10 PRAG1 MAP3K19 MRPL4 XLOC_008362 PDCD6IPEXOC3L4 STK3 ADCK1 RNF6 ADAM32 XLOC_I2_000394 TAS2R5 RFC4 PDGFRL SNRKRABGGTB KCNG3 FRMD5 MC3R GLTSCR1L DNM1L POU5F2 PCDHA8 CPSF2 KIAA1324RAB31 KLHL26 NME2 ODF2L NO_MATCH_3 FASTKD2 NXT2 C6orf58 VRK2 OSM BRD8MST1R BLK TCOF1 SLC35F5 RHNO1 PTEN APBA2 PRKX AK1 BRS3 ALOX5 SLCO6A1ITPKB RARS HBG2 TOMM40 NO_MATCH_61 HECTD2 SEMA6D SLC6A2 OXTR RNF34 PPWD1NFE2L1 SYTL5 MARK3 CYP11B1 CKS2 HIKESHI ZNF433 MAP2K4 CAMKMT CNMD CMTM4PBX4 ABL2 CAPN9 BUB1B PPM1A PLA2G4C TMEM110 CES1 ZDHHC20 GALNT14 S100A13NUP210 IRAK4 SLC14A2 OR8B12 TEC DTWD1 MERTK TPGS2 CBLB NXPE3 RAB41 THADATFAM TCHHL1 RAB34 HSD17B7 OR4K2 BMP7 FAM19A2 PCDH20 MAP4K5 TRMT1 PWWP2BMRE11 PPP3R1 TCTE1 OPTN NOX1 ZNF660 PNLIP THEMIS2 CNTN2 RECK PTH2R CNGA4DDX27 FAM208B CERS4 TUBD1 HTR1E RPAP3 PAK5 CFHR3 IQCB1 TFE3 ADGRG7 SCYL2IGSF8 PIP CALR3 SAMD4A NO_MATCH_223 LRRTM4 ZNF3 TRAPPC1 ECT2 KIFC3 EPHA1PAGE4 NDUFA2 TPD52L3 PIP5K1B RET MCEMP1 PDGFRB TTC30B UGT1A4 PRKAA1B3GALT2 42989 MINK1 TMPRSS13 PCDHGA6 HTN3 ALG10B ARG1 NR1H2 LY6G6FNFATC3 ZNF302 DFNA5 SNCAIP TAS2R14 CSNK2B AGTR1 TMEM2 PPP1R12A SPATA13TDP1 NDUFA4 TAS2R13 KIAA1524 SRSF4 WDR93 PANK4 DGKG ZNF331 VPS39 LRRC37BTAS2R50 PDPK1 PRPF40B TYK2 MRPL28 RABEP1 COL5A1 SEC23IP SRPX2 PPDPF EME1SLC2A1 MAT2B XPO5 EXT2 FOXN4 CERK IL2RB ACADVL ADRA2B GPR31 BUB1 TDRD9GPR6 ARMCX3 RPS6KA1 TAOK3 DHX38 AQP4 PCSK9 DYRK1B DRAM2 TAS2R31 ACVR1BCKS1B C1orf186 MTERF1 CDK9 PRPF6 C9orf170 SAP30BP PUM3 PACSIN1 ZFYVE21PCK2 SLC5A7 SPINK2 ADGRG5 EIF2S2 MSN DGKZ CCR8 PER3 ERBB2 MAPK8IP2ADGRE3 RTN2 FGA MTMR10 EFHB LILRB1 SLC22A7 R3HDML MAPK1 CCDC141 WFIKKN1OTUB2 CWC22 ADGRE1 MC2R COPS7B PCDHGB4 SENP6 CLK2 EXO1 CHID1 LY96 DEKATP9B C1orf101 MYLK4 KCNK7 GPSM1 TCEA1 DHX40 NPHP1 MARK3 MORC3 LRCH3PFKFB1 OR5B12 ATRNL1 IL17F FRK CRTC1 ATM NO_MATCH_280 KIF7 POMGNT2 ADIGMIA2 HORMAD2 PFKL HINT3 DGKK MX1 OR2D3 VEZT ZNF260 TFIP11 VASN NCAPD3GPR149 RCHY1 DEFB4A DARS2 KLHL2 GJA4 NRROS PDGFRA RPUSD3 SIK2 PHKA1ACKR3 SQLE Xkr6 ABCF3 INSRR SHC4 GALNT7 CHD2 DZIP1 MAP2K2 SS18 PCDHA12RING1 PRR16 RAB27B TIMP3 ROCK2 LIMK2 ANKS3 EPHA3 AGPAT2 CPNE8 ADORA3BSCL2 AP1G2 PFKP PAK4 SART3 PTK2B RBM19 SPDYA MAST3 TLE1 PTK2 C19orf70ANGPT1 ERC2-IT1 KATNAL1 SLC27A1 SLC22A14 CLK4 DLX4 BMX MCM2 USP2 VPS25BCL2L14 MAST2 PIAS4 APP NPBWR2 ZNF677 MRGPRX4 CDK4 PPP1R13B USP1 ACVRL1ZNF786 LOC55338 RNPC3 HIF1A MAP4K5 RBMX2 RHBDD3 ASPSCR1 DEFB104A ACAA1ALG14 ERMN PYGB PGLS MMP19 DTNBP1 NECTIN3 SERPINB3 RBM6 GLB1L3 MRPL3ZCCHC5 ABL1 EEF1A2 CCDC89 YY1AP1 RXFP3 MSL2 PRKACG BRAF ADGRF2 SYK MAPK7MCM5 SLC5A11 MGAT3 SCFD2 HSPD1 PPP1CC FCRL5 SSRP1 TXNDC16 PAGE3CH507-42P11.6 DHX57 ACSL5 OR52N5 CLVS2 IGHMBP2 GAS2L3 UBL4A ELL TRAPPC12SLC15A1 PNMA2 CCDC40 UBE4A HTR1E IGFBP1 SNAPIN CBR4 FAM234B GPR183 HDXMDM1 KLHL12 ZNF513 TUBGCP3 IFIT3 OR51E2 PIPSL ANXA2 PRAF2 FAM200A FAM30ASLC28A2 CAPN1 PRPF19 PUS7L RPL35 FAAP100 SORCS1 CYLC2 IMMP2L WDR46 ATAD2NSUN5 SYK NEK4 LZTS2 YY1AP1 INSIG2 SORCS3 RHBDL2 CD200R1 SMTN SP100TPRG1 CHST15 PPP1R16A LARS2 ADH1C FAM98A ELF4 ACKR3 GPR39 ADGRE5SERPINE2 CYP19A1 NAA30 C6 ABCC3 KIAA0391 OR2AK2 ZNF670 MAGEB6 ABL1ZNF124 GRM6 EXOC3 HCFC2 SPANXC PPP3CA RALBP1 ERGIC3 AXDND1 GRIP1 GPR101OGFR KLC3 ANKEF1 PLCL2 TRPV5 TAS2R43 MTDH ERBB4 CALM3 LINC00574 TKTL1ITGA5 MYOD1 CASQ1 SPATA6L FZD3 PPFIBP2 SLC4A3 HSP90AA1 TYK2 TEX10 TRPS1FGFR3 POLK KRT2 CDY2A PDK3 CEP57L1 ADGRG1 ACKR4 CLK2 HIST1H2BH PAPSS1MAN2C1 GLIPR1L2 GRPEL2 NO_MATCH_216 PTK2B KIF2C OR52K2 GTF2A2NO_MATCH_176 RABEP2 NHLRC4 MAPKAPK5 PJA2 MTFP1 HCAR2 GIP NUSAP1LINC01312 ARHGAP44 JAGN1 MYL2 DPP8 PSME4 CDH23 VWCE PCDHA2 TAOK3 NMITOR1B SMURF1 TNIP1 GAREM1 SAMD3 KLK11 ST5 OR10W1 BZW1 DDX39A STK33NUDT16 GPR75 ADCK1 ZNF678 ERN1 HCK ZNF112 SERTAD1 Nalcn PFKP RPS6KB1E2F3 DYRK2 NET1 ZNF791 FKBP9 RNF40 TBK1 SNRK NLRC4 GLP2R PRPF4 DTX3LZNHIT1 GSTA1 UBE3C MMP2 POMT1 N4BP2L2 CHRM1 ZNF23 ZBTB48 DHTKD1 CLK2CTXN1 NTRK3 KRTAP5-6 PRKG1 MTM1 NO_MATCH_231 LCK TAS2R31 ATP6V0E2 ZNF136SORBS1 SPAG8 ARHGAP17 FOXM1 EPB41L2 DDX55 SF3A3 WDR91 FTSJ3 PLPP4LOC105371493 PFKL LOXL2 PFKFB3 SSTR1 GPSM1 FKBP2 RBM10 ZFP2 P4HA3 AFPPTPRH TSKS MAPT GOLM1 FZD5 LUM DHX38 FAM217A FPR3 ZNF426 ZNF177 CFHR3ISOC1 NMUR1 PKN3 SPG20 ACVR1 IFI27L1 STK16 SCYL1 CTPS2 DUSP6 IPPK DDX18MAP3K6 RIT1 PRIMPOL OR5C1 PCDHAC2 HSPA12B STRBP LILRA1 DNAJB6 CTNND1ELAC2 FPGT-TNNI3K KCNJ3 OXGR1 RINT1 BCL2L11 ATP6V0E1 RIC8B MAX LMLNZNF658 MAP2K5 TRIM5 BVES SSTR1 CYP2C18 DDX19B 42985 ADCY2 SIK2 MAT2BCHRM3 PPM1E LRFN3 RPS6KA1 PDGFRB RAB3B TUBA1B SPEG SPPL3 BMX PFKL NGRNTRIM15 EPHB1 PANK2 MEIOC TRAFD1 NR3C1 IL13RA2 PTPN12 TGFBR1 TMPRSS11BNECAB3 ELMOD3 LTB4R2 ZNF326 IREB2 USH1C SLC30A4 DYNC1I1 SH3GL3 TRPC1LOXL4 LYZL6 GPR153 LOC102724334 NKAIN1 SNAP47 USP15 NO_MATCH_234 RPS11MCRIP2 AP2B1 S100PBP MAGEB3 OAS2 RPL23AP7 BMX KLHL23 PRKCD IFIT1 FMODNTRK3 SAMHD1 NPSR1 PANK4 PTPN3 OR51M1 SARS SPDYE17 PCCA GPR101 FGFR3PRKC1 GRHL1 PLOD3 AGT SLC35F2 CENPC TACR1 PHKB Zfp777 ZNF586 UTP3 TGFBR3TBC1D10A HFM1 MAP4K2 BCAP31 SLC27A2 C17orf105 ROR1 STX5 SLC2A2 ADAMTS15CPEB1 BCO1 NOXO1 ADRB2 UNC45B MYL3 BRD4 DPH1 AFTPH CALM2 PHEX LRRC6PTPRN2 MAPT GPR75 EMP1 TK1 SPP1 SULF1 PTK7 ZNF219 PFKM IL12RB2 PYGL CLK3CCDC162P TMEM182 SLC52A2 GNPDA2 ATAD3A TGFBI PRF1 PLCL1 HSP90AA1 MORC2FGD5 SIM2 ENTPD5 TRIB2 GTSE1 REC8 HNMT GRIA3 Clpb TXNL1 WWOX CKB GTF2E2SERPIND1 WDR34 DDX18 TSTD2 GNAO1 DNA2 RPL34 CAMK2B C8A C2orf15 CD36 NEXNNO_MATCH_38 RASGRP3 TLK2 VILL CLOCK NO_MATCH_246 NCAPH2 DDX41 FAM49BNKD1 POLR2D Osbpl6 EPHA1 CTSS GNAI1 SMYD4 ASIC1 MFSD14C PPP1R16B ST8SIA5UGP2 TPP1 RFX4 SIK2 ARHGEF40 TLE3 TMEM260 MOXD1 ZFP3 JKAMP CDC20 RTCBDPP7 JAK3 FAM111A ZNF214 DSC2 CBR4 MRGPRX2 NO_MATCH_196 ERBB2 CASC1Tmprss7 IRAK4 MAS1 CEP63 PRB4 TECPR2 KIZ ETV6 PIGX DEFB125 GJA1 XRN2ADRA1B RGL3 MLNR HDAC7 NTRK2 NMRK1 KIF3C CKAP4 FLT4 PIK3CB PEX6 LLPHFAM13C DEFA3 PRAME PHF20L1 NO_MATCH_89 DSE TAS2R16 SPTY2D1 E2F8 ELL3VLDLR NO_MATCH_244 HIST1H2BA METTL17 FHOD1 CWC27 SARNP LASP1 SMARCAD1NTRK2 CACNB2 SLC28A3 LOC102724023 USP11 LARP1 PARD6B TESK2 TP53BP2URB1-AS1 NPHP3 PTER XLOC_I2_004594 EIF4B ZNF775 PFKM EEF1D IDI1 NPY2RCHGB OTC BIRC2 NR4A2 APOBEC3B RDH11 PLB1 LILRA3 TBC1D2 PPP3R2 ABCF2FRMPD2 SLC35A3 NPR2 CORO7 MAPK7 SLFN12 OR10H1 VCAM1 PPP4R2 IFNL2 SYNGR4OPTN FZD7 CCL20 CSNK2B MRPL33 RUNX3 LFNG STK24 MIA2 TOMM70 LCP2 DUS4LACADM PIK3CB CRTC2 NO_MATCH_275 TGFBI C7orf49 LARP1 CSNK1D FZD7 PDXKZFP64 CYP8B1 CD6 TCF25 NEXN UGT3A2 XAGE3 FGR ADRB1 AXL CAPN6 FRMD3OSGEPL1 DTYMK PRKG2 FASTKD3 FER LARP7 DERL1 B4GALT6 SKIL BBX DRC3 CHMP1BNO_MATCH_189 WAC MYBL1 ZNF645 SNX9 KCTD3 MEF2A ODF1 HIST1H2BG PGAP2DEFB106A QPRT ANXA10 FGGY ZNF394 FAM45A LAG3 SIRT1 OPRL1 FZD4 RNF20MPEG1 KCTD12 PIK3CG NAT10 PKN1 RAD51AP1 LGR6 CCNC KIAA2013 ACAP3HIST1H3H PAK5 ELOA2 ART1 KCNRG SP4 C10orf67 ZNF34 ETS2 NO_MATCH_62PPP1R42 XLOC_I2_004840 LOC107986912 NO_MATCH_121 IGF1R CBLC NO_MATCH_210KRBA1 KDR ADRB3 ARID3A TRPC4AP GSG2 DCST1 CNBD1 BPI CLK3 CARD9 TMEM5ULK4 ABCF3 GPR139 DRD1 FAM161A PPP2CB ATP1B2 FAM114A1 FBXW7 AMOT GNRHRMUSK SLC7A8 FGFR2 SELENOT SLC35A4 SLITRK4 MRRF PITPNM3 LYN PEX6 DPF2EYA4 PSMD14 KRT24 ATP5B TCF25 ADPGK NO_MATCH_27 CEP19 FXR2 CKB FHTAS2R39 TRIM6-TRIM34 SMAD1 SLC7A9 GNE L3MBTL1 PLA2G12B CHRM3 PPARGC1BTTLL7 GPBP1 NEK8 NPM1 MAP2K5 MYD88 AP2M1 DPP6 ZFY LRIG1 PTK2B RSPH1NO_MATCH_162 EZH2 GCLC WWTR1 SLC44A5 USP2 WASF1 RMND5A ARPP19 PINK1PPP3CB PIK3R1 PRKG1 GPR68 GTSE1 OCLN TLR8 RPL6 CGA P2RY4 GOLPH3L TMEM252TNIP1 TNP2 TAS2R43 ICOS PPP1R21 GTF3C3 CFAP97 PRRT3 PRAM1 LINCO1711 TPH2ZNF350 TMEM108 AP3D1 TAS2R20 HP CASR SRPK1 MCOLN2 PPIL3 DNAAF2 ZMYND11STAT4 CORO6 MYO10 ALCAM TM7SF2 DNAH6 ZKSCAN1 ALAS2 TLK2 CDKN3 DNAJC3PYGB HNRNPH1 SLC1A1 ZNF554 EIF2S2 KCNE4 FAM19A1 NSMF IFNAR1 ZCCHC14CAMKV CEP290 CDC45 PRIM1 MAP3K20 INPP4A SLC23A3 TMEM229B HNRNPF CNOT10ATL1 WDR47 PIGY ADRA2B DET1 MMACHC ADCK2 TGOLN2 PRPF4 TBL3 RPS6 F2RL1DDHD2 GRIN1 C10orf25 DIRAS3 THOC1 GPM6A CHRM5 COL20A1 PTGS2 ALDH2SLC5A11 NUAK1 EXOSC3 TEX30 C11orf24 SNX14 CAMK2A GSDMB ZNF213 OR8I2MGEA5 UBE3C PAK4 PCDHGA5 CCT5 USP46 RELT TTC9B CADPS ANKLE2 RNF213SLC28A3 SYNPO2L CXCL2 AZIN1 BEST1 CCR8 ANKRD54 NO_MATCH_184 SPRR1B SYKWDR19 CDADC1 EYA2 MAP3K20 UQCC1 42801 USP33 ZNF783 LMOD3 ZAR1L CEP76PRKAA1 RCN3 TRAF3IP1 SYTL4 MTHFR ILDR1 CAPN13 KSR2 LRRC18 SLC47A1 RPEL1PNLIP TNFRSF1A HNRNPA1 GALNT9 KCNAB3 EGLN1 KNOP1 NTRK2 TPPP WDR76 BMP5ADGRG2 XLOC_I2_006010 NAB2 RFK CDYL2 FAR1 DIP2A FBXO30 SLC22A14 PTPN9ZNF567 SMAGP LGR6 POF1B LOC107987253 CIRBP-AS1 IGFBP5 MEPE CDC14A FUKTINAGL1 LUM OSBPL11 PKMYT1 SYNCRIP FBXL16 RASGRP1 ZNF18 MAX SPON1 HECTD3SRSF5 MISP UBXN1 THUMPD3 TBCEL TSPO IFT57 BMPR1B ATP5H PAX8 CSNK2A1USP30 SRPK2 KLHDC4 DPYSL4 ZNF800 NTRK1 SLC28A1 EPHB2 AQP10 NPBWR1 OR2L2HADHB C9orf142 ANKHD1 ZRSR2 ZGPAT ADGRL4 JADE2 PGM2L1 FYCO1 EDNRB LIPFLUC7L DNAJC19 FBXO5 NOP2 G3BP2 SLC3A2 SERPINA10 P2RX1 CHST12 NPR3 SOX5ZNF34 MAP2K1 TTC19 CSNK1G2 RAF1 TP53BP2 IMPG1 HOXA9 PES1 GADL1 TNFRSF1ACOMP SUMO1 SPHK1 CREB3L1 SUPT20H ZNF485 OGDH OR11A1 RUNDC3A LPAR4ATP6V1B2 TKFC EID1 PDE3A CRYGS RXFP1 DRD4 SLC12A1 SELL PDZD11 ICAM3ACSM3 CAMK2B PPP1R7 ANKRD10 PALM2 NO_MATCH_133 LGALS3BP TBK1 SPARCZNF530 LAMTOR3 MFGE8 BRS3 COG5 ZSCAN21 TNFSF14 ARRB1 ZNF224 RXRA RARBDCAF8L2 ZNF33A SHTN1 TRPC4 WDR20 MRGPRX4 EEF2K MINK1 SLC2A9 GPR87 GPT2MPND ARHGEF28 SMAD5 ATP6V0E2-AS1 PCDH9 REP15 OAT TAS2R40 MOAP1 G6PDDACT2 GK GMPR MTR TIGD4 TMEM243 PAX7 ZNF449 ALPK1 HSPA1L SIRT6 ZNF829CPEB1 TTLL7 PI4KAP2 AXL POLH YIPF1 SYCE1 ELAC1 ZNF254 YTHDF3 COL8A1BMP2K REN Myt1 EIF2AK3 RTKN SCGN NO_MATCH_264 SOX3 RBM28 RYK GSC MRPL43PA2G4 GATM SPNS1 NO_MATCH_15 MAP3K7 SYNJ2BP OR4F16 TTC6 SFSWAP DCBLD1NR0B1 ST7 42990 DAPK1 CABP1 ANKRD13D RPL35 POP5 GCK FYN SRP54 PDE1C EOGTAGRP BRD8 ERH PIK3CD NO_MATCH_220 HIPK2 APBB3 ADSS FAM86C1 TOR1AIP2MAPK9 SULF1 TNPO2 NPR3 C20orf27 RIOK2 SACM1L OMD SRC NO_MATCH_172 MPP3ZFP82 GRHL3 FSCN3 PEAK1 C12orf60 BTK PDE1B SLC25A21 Rassf3 PDE9A AGTR2ZNF532 CHUK OR6B2 NELFA C12orf40 GRIN3A NOX5 LDHC NFYC NEK5 RARG CAPN11ADGRG2 TAAR2 JAKMIP2 PRPS2 PPIL4 C2orf73 ZNF655 DRD4 CXCL8 FAM83B POMT2PKN2 NLN ADAMTS12 ZIK1 NELFE NR1H3 DYRK3 SSX2IP ZNF607 UMPS NO_MATCH_91PLK2 RASGRP2 TGFBR1 TDRKH TULP2 HPGDS AQP9 DYNC1I1 PPM1D EML3 RNF219ADORA1 MIEF2 STOM NDUFAF5 HK2 ZNF544 CERS2 WNT5A ARHGAP8 ZNF2O2 MOXD1TRPC5 CCDC38 XLOC_005923 CNR2 SLCO3A1 WNK4 CHRM1 MRPS18B TRPM8 TRAM1OSBPL5 CDK16 EIF2AK2 S1PR5 DNASE2B RANGRF DEFB119 PSKH2 FBXO25 PTENHLA-DPB2 SF3B2 PPP2R2D DUT PSMD4 ARMC5 LIMK1 PDZK1 PIK3R5 TRMT6 GGT7ZNF404 BST2 HMGCR NOL9 FUT2 CFHR5 BMPR2 HNF4A LOC101060386 NME1 CLHC1CCDC186 GZMA ARFGAP3 FUK ANKRD44 S1PR3 APPL2 MLPH PRIM2 RPL21 UBA5AMMECR1 SCYL3 GUCY1B3 OCLM CHRM4 VILL MAGEC2 CSNK1G2 SENP2 CLP1 KLK15LAIR2 POLR3E TOR1AIP1 CD1B FAM209A RPL22L1 CLINT1 ZNF345 DMC1 ARHGEF7KCND2 PCDHGC4 ALDH6A1 TAF1B RSRC1 ZNF333 XPNPEP1 PHYHIP ACAA2 ZNF558NO_MATCH_69 PTPRO KIAA1143 P2RY13 TOM1 AGBL5 CYP4A11 HCRTR2 RASA3 GPR82Acss2 RIOK3 NO_MATCH_271 BEX1 TNFRSF1A TSSK1B CCR4 LCK SERPINB6 SPHK2PLEKHO1 MOXD1 PPP1R18 SYK CDC5L TACC3 PRKCI DAPK3 AK9 PDPK1 TRHDE FIGNL1MAP3K9 WDR74 ISL1 NPR2 PITPNA GNE FOXRED1 PNPLA6 POLR1B SSBP1 CAPN5 MIIPNARS RBKS MGST3 GNA12 RPS6KA3 GRK3 PAPSS1 EIF2AK2 PRSS1 ADGRG7 ESRRBNO_MATCH_134 GAB2 NO_MATCH_215 DNHD1 42988 ASXL2 STK11 GRM8 ZC3HAV1IFNAR2 ADH4 SPATA22 CCHCR1 PPP1R8 DIP2A NAGK COQ6 UBE3A MAPK8 SRPK2Usp48 POLD4 ZNF253 ZNF334 CHRM5 TCEA2 SIK3 ALKBH5 AGTR2 ZCCHC8 ACCSSH3BP5L IGF2BP3 RGS3 NLRP4 PRKCA CDSN JAK3 EIF3L LPL WDTC1 NPR2 HDHD2SRP54 UBAP1 SBSN ZNF622 GRK2 LARP1B XLOC-013189 PCM1 MRFAP1 NO_MATCH_195FAM161B RGS13 KIF5C WDR1 POTEB3 SRGAP1 UNC45B FBLIM1 STK3 PAK4 CCNL1ARV1 TRAF3 GBP6 BRD2 KXD1 LATS1 C3orf30 MAPKAPK3 BICDL2 DTNB GNAS GRM2NUMBL KLC1 TTI1 GGT5 KRT23 SSH1 RLF DKC1 PRKX FXR2 MAP3K14 NSD3 ARNT2NO_MATCH_108 CYB5R4 POC5 HSPA9 ICOS PPP1R15A IRAK4 C3orf62 RPL7 MDM4C11orf57 C3AR1 ATP6V1B2 SGPL1 DNAJC7 LIPG IRF8 NO_MATCH_126 FASN PLK2L3MBTL3 UTS2 CCDC136 TAAR1 FAM134C GPR85 TAS2R42 MAPK14 HSPA1B CMTR2DDX21 VPS45 MATK GGTLC1 ZNF695 ODAM ATG3 TAOK3 TPR CPT1B ZC3H11A AP4B1CYP4F11 DBN1 TRIM41 C6orf48 TNK1 PLK2 QRICH1 TRPV3 HES1 ZNF146 DAZ4 CD86HOXC10 MPP5 FSHR ALPP INSR PRC1 ZNF618 RBM47 PLXNA3 GCC1 SSX2 TRIP4CRIPT ZNF439 SLC2A11 ZCCHC9 USP37 CRY1 DCBLD2 MMP15 DBNL MAP4K2 GCSHDDX11 KLHDC2 RIC8A DMPK PCSK9 LASP1 SLC5A7 TSN ZMYND8 PSMD13 ZDHHC17HIKESHI EPHA5 ZNF467 SYNDIG1 ENTPD3 ECT2L XLOC_013689 PAX3 PDCD1 CLK3CLK3 MORN2 TAS2R19 RIOK2 MTPN UTP11 GALK2 ACTR1B AKT3 ALPP EBF3NO_MATCH_51 SLC39A1 NXF1 IGFN1 TIMM29 MFSD13A TAS2R19 KLHL11 CERKSLC27A4 PSMC5 TM4SF19 ADRA2A CRISP2 IL1R2 PCDHGB2 SLC22A5 CDC25A ZBTB8OSAPP PFKFB1 GPR156 HIST1H2BC AOC2 PLK3 TESK2 SLC4A1AP RHOBTB1 USE1 PLVAPSTAU2 BLZF1 CLMN EPHA2 LRRC49 LCN2 SELENOI MRPS17 ZBTB24 HCAR3 AGPAT1ELOVL5 TGFA C19orf57 FABP4 FCGR3B CAPZA2 LRRC14 ZNF577 PPIP5K1 EIF2S1ZNF273 POPDC2 CELA2B GLUD1 PTPDC1 POLD3 FAM71B BMPR2 42982 PPP4R1LEEF2KMT KCNK15 ABCA9 FUZ SLC35A5 EEF2 C19orf44 FBXO24 ULK2 SEMA3C CTC1HMMR TFDP1 GLOD4 ZBTB14 LLGL2 NR1D2 NUP37 SPHK2 MAPK6 CDIPT PCK2 YAP1MPZL2 ASIC4 PRICKLE3 CPNE4 BTBD10 DNAJC14 CDK18 LOC153684 TM9SF1 MSI2MAPK8IP1 EDNRA CLK3 MS4A10 CA5A STK38L PREPL MDM1 RIPK1 OSGEP HSPA6XLOC_014105 ERBB3 MANF KLC3 DRAXIN NPSR1 YTHDF1 ZFAND4 GNS PMM2 STAG3KLHL36 KRTAP22-1 SUN5 XLOC_010072 BAALC-AS2 TIGD5 OR5M11 SLC26A2 TMEM177PASD1 RSPH4A SLC2A2 NTRK3 DDRGK1 GLP2R PRPS2 LRRN3 KCNS3 OPCML MAP4K2SRPK1 CDC23 VIP EML4 RASSF6 OR8B8 ACSF2 SH3D19 MC2R KRT6C RBM5 C17orf47EXOSC3 NEK6 MPHOSPH6 RNF182 KRTAP8-1 CHRM4 PDZRN4 SLC52A2 SLC35A5 DCTN2ZBTB12 GPR25 PNLDC1 KRT7 STAT5A ORM1 KIF3C PPBPP2 DLG5 DSCR8 AVPR2PRPF39 SERBP1 TLK1 PTCD3 UBE3D PAK5 PLK1 MFAP1 PPOX CNOT3 TCF7 RNF139PRKAG2 CELF5 SDCCAG3 KCNA6 NEDD1 DMTN SNX32 IMMT VPS50 BLK RHBDL2THUMPD2 CLK4 NCOA4 MAPK10 OPRL1 REXO4 SLC35A5 DPH2 HPGD MAP4K4 ABCD3UMPS IL18RAP PRKAA2 SEC22C CFAP57 ZNF764 BAZ2B HDGF MAP3K8 LINC00477BTN3A2 ATG16L2 TMCC1 TRIM65 CCDC81 GAPDH ILVBL ZNF645 GPD2 KIF12 XPO5PMPCB BMPR1A HIGD1A ZFYVE26 PCSK5 BIRC8 TYW1B Aak1 FLT3 CDKL3 STK25FADS2 EPSTI1 U2AF1 CMIP CXorf21 HK1 ATP5A1 BMPR1A RABGAP1L ZNF415NO_MATCH_132 C3AR1 RWDD1 ZFYVE1 PCK1 PRKCZ OPN5 DLG1 CLASP2 LRRC19CCDC112 MLX ZNF76 ESR1 SPRED1 VN1R10P IQCC CALCR CISH FAM213A NAP1L1GPR85 ZNF837 ATOH1 CTCF PLTP EP400 WDR76 CAPN8 EPB41L1 ZNF75A UBAC1C11orf58 DONSON COMMD4 ABCB6 HTR3A PHF20 KIF9 MRGPRX2 NPY5R MAP2K7 CLIP3PFKL SLIRP SLC28A3 CDC123 SMCR8 IP6K3 TBX22 YES1 LRRK2 PAIP2 RSL24D1CNDP1 FGG RNF31 PALM SPDL1 NTRK3 HOXA1 USP10 ZBTB39 GALNT1 MSTO1 TBX15ATPAF2 HOXC9 GPBP1L1 XLOC_I2_006797 FOXO3 PHF21A Ube2o AHCYL2 DHX30ST6GALNAC2 SRD5A2 GPR61 MESP2 SYK ARHGAP17 CHPT1 PCOLCE2 CYTH3NO_MATCH_112 ADAMTS1 ZNF599 AK9 NCF2 SNW1 NMD3 FADS1 BRPF3 C22orf34SLC41A2 OR13A1 TRIM44 CKM IFNL3 MCM7 RHOH FZD10 ADGRE2 CNBP POLE2 RBM48PPP2R2C PICALM FAM43A FANCC PDK1 ZFP91 OR7C1 42980 GANAB NO_MATCH_124KIAA1324 IL13RA1 TUFT1 POLR2M ZNF257 MCMDC2 RARS2 CRTC1 ARHGAP22 MAJINGFOD1 SLC2A13 NDUFB11 OVOL2 TCF4 KIAA1257 RGS22 ACVR2A PRMT1 RBM46 PRKCQSEMG1 ASS1 OXCT1 CNOT9 HDAC1 EFTUD2 PDK2 TCF7L2 DAB2 HIST1H1C IKBKE ILF3NEK10 INTS4 POU5F1 IKZF3 ZC2HC1A NCOA5 GAD1 ACTBL2 EXOSC10 RYK CCNG1STYK1 NOP10 CDK5R1 MVP KIAA0319 ARHGEF25 MAP2K3 GPAM PSKH2 ZNF225 NADKHTR2B GPR139 OGFOD1 CMKLR1 ATXN3 PPIL2 MKNK1 KNG1 RPS6KA3 MAP3K7 SPERTSASS6 SLC2A2 PAMR1 XLOC_001272 MRPS15 GRAMD1C SUFU ZNF613 LYSMD3CHRFAM7A LMO2 MINA SREK1IP1 SSX2IP MYOC TLR2 GRM7 PIK3R5 ENTPD2 KIT GAAPAK3 AASDHPPT CKMT1A EYA1 PRKCB ORC6 PRDM4 NO_MATCH_154 NO_MATCH_102HEATR1 MLLT3 TOB1 CBX6 FGFR2 VDAC2 PDCD6IP MAPK11 FZD10 OSBPL3 MAP2K2TSPAN1 HDAC6 DNAJB3 LRTM1 SOCS6 SPRED2 RFX3 DUSP19 KCNN2 SORD MYO3BHADHA SMIM8 KIAA0319L LSR SCARB1 JAM3 RSBN1L SEMA3E XLOC_I2_006166 PRAMEFAM114A2 NUDT16L1 BTF3 PPP4R2 LHCGR CCL22 EPHA7 GCLC RNF135 SNX25 SFPQZGPAT SSR2 42984 TOR1A SLC26A11 CYP3A5 TEPP RPS3A BMP10 NPR2 TYW3 FOXA1ART3 TAC4 ASGR1 C9orf43 PSAT1 NT5C3A UTP4 GPR78 SULF2 TMEM39A PNN NSMCE1IFT81 FAM150A GPKOW MAPK4 MARVELD3 DPH6 MCF2L2 RIOK1 TOMM34 B3GNT5 CAPS2CFB HLA-DRB1 FYN HIST1H1A LSS TFG HIF1A FBLN7 ARHGAP28 TRMT1 GTF2H1ADPGK PLPP3 DHRS9 VAT1L TSEN54 GPR35 CYP20A1 SLC26A2 SULF2 LRRFIP1 SDHDAMHR2 NO_MATCH_103 EEF2K IFI27 OR8G5 KIFC2 GNA14 GLTSCR2 CLSTN2 GPBP1L1CYP39A1 HTR3E SPIN1 RLN3 RHBDF1 KLHL31 PHB NMB MEIOB TSNAXIP1 NRP1CTDSP2 SPESP1 COLGALT2 FAM83F JOSD2 PDGFRL SPRTN TMEM42 EPS15L1 GSDMCJAK1 FGF7 GMCL1 SERPINH1 OPRL1 SNX7 RBBP5 PYGB STXBP3 AKIRIN2 PIN1 USP44PDXK AKT1 ARRDC3 PMF1-BGLAP INPP5E NO_MATCH_19 LALBA HS1BP3 RSU1 MMEDGKE DPYSL5 ICAM4 COPS4 OR2H1 CCR3 TCF7L1 SAMD4B STAU1 HSPA1B CDC73PPIL2 BOLL TBXA2R SEC61A1 FGFR1OP CDK11B TMEM14B FGFR3 BABAM1 KIFC2LRRC37B ZNF57 B4GALT4 CDKL1 URI1 ZCCHC10 PAK2 GPR26 RANBP10 SUCLG2 HLA-FTRO ARNTL SLC18A2 ADORA2B EFHC1 ADSS NR1I2 GPR151 CST11 DGCR8 TMEM45ARRAGC METTL25 DEFB121 CDC7 ALG10 CCDC91 STRADA ACSM1 NDUFAB1 SLC17A1ABAT IKBKB PLEKHG6 OTUD3 TRAM1L1 SNU13 HOOK1 PSG5 INPP5D FASTKD5 BTKMYNN PPP2R3C STRADA NSUN2 GPR119 SYN3 CPPED1 KLHL36 FGF9 EPHX1 NR3C1 CA2ELMOD1 RACK1 SYTL5 PPP1R2P9 ZBED1 PCDHB5 NO_MATCH_174 SLC26A9 SP1XLOC_009028 XLOC_003546 ERO1B ZNF561 MTHFR HSD17B10 Olfr981 MAS1 ZNF366CLIC3 AIFM3 ETAA1 TRAT1 DDR1 NO_MATCH_262 TNK1 OR4C12 TNFRSF14 ACVR2BNO_MATCH_36 TCEAL5 GSPT2 GAPDH HTR7 PUF60 ACPP MCPH1 GPC4 NUMB APOBRRBM4 GPBAR1 PAPSS2 TXLNB CXCL11 MB21D1 HDGFRP2 WSCD1 RHOBTB2NO_MATCH_175 VPS28 PIGP MCM10 EIF2S2 IRX2 NUAK2 DCAF8 CX3CR1 MAP3K20KRAS REC8 ETFA PDXDC1 CCR8 ANGEL2 ADA SULT1A3 MKX CCR5 SULF2 KLHL4OR51B4 TNNT1 SRPK3 ARMC10 CCNI MAST3 C7orf25 PGD IFT22 MOXD1 PUF60ADGRE5 PTER CDKAL1 AP3M2 ZNF232 EFCAB7 RHOD JADE3 BMP4 SIRPA ZNF264COX7A2 GNG13 ZC3H12A CIDEA RNMT CHKB Rbp1 KRTAP4-12 TYRO3 FCGR3B BMP2KSCAMP1 NO_MATCH_21 NR2C2 KAT5 SRRT DKC1 TIMP1 GABRA4 SCYL3 COMT PCGF5MTMR14 OR8G5 SCPEP1 TXNDC5 FFAR1 CHRNA7 THRA HCRTR1 KIF12 TEPSIN SYCE3DLAT ALAS1 NGDN DEDD2 NPSR1 MAOA MAP3K11 NOL4 QSOX1 PDHA1 KRAS ANKDD1AENKD1 DNAJA1 CCBE1 ZNF792 MITD1 UPP1 USP5 BLMH SCYL1 KIF2C JSRP1 PRMT6RANGAP1 SERPINA7 MAGEF1 GNL3L PAPSS2 DNAH17 CHGA Csrp2bp TRAF5 KPNA3 CSKCCM2 EDIL3 PCGF1 PPWD1 COQ8B COPS5 KCTD13 FTH1P3 C17orf80 WLS USP54HSD17B11 BMPR1B DGKA MAP3K5 TSPAN6 P4HA3 PROKR2 DDX53 IL2RG S1PR2 MIER1TCAIM DCLRE1C NT5DC2 NBN DHX57 BAIAP2 DDX39A RGMB CALY FAM46DNO_MATCH_56 MPZ HCK TMPRSS11A PHF1 IRAK4 ENTHD1 VRK1 BRINP2 ARHGEF10TSPAN18 SMO VIPR2 UQCRC1 TAGAP MRGPRE ZNF454 SMG6 S100A2 TFR2 GNAI2PLAUR FAM124A USP12 RCVRN NO_MATCH_117 SFN VIPR2 GABBR2 NSMAF VMP1 TIGITRHPN1 SNTG2 ABTB1 NDUFS1 GPATCH2 INTS5 ZRSR2 FOXB1 ROR2 SCP2 ITIH3SEMA4C ADGRG7 RABL6 ZNF266 USP27X-AS1 PRR3 FUT8 PCDHGA7 ATCAY PDE1BDNASE1L2 WSCD2 AURKB SNAPC5 GSTK1 MAS1L SLC38A6 DBR1 TNK2 SERPINA12SLC25A13 ACVR2B FES RGS6 RNF144A GPNMB PLEKHA8 ABL1 HOXB13 ATXN1 GPR101SLC2A5 CERCAM LMOD1 PEPD EPHA7 STK38L SMG5 HNF4A SIRT1 AP1M2 GPR161DIDO1 GPR4 DRAM1 LDHAL6B EIF2AK1 OSBPL5 CLEC2B PPARA VEGFA SPOPLMAPKAPK2 GDI2 GPR6 PRKACB MID2 NO_MATCH_239 MATN4 RASEF PARP15 MS4A15ARSF WAPL TBC1D22A NECTIN3 GPR157 ATG4C OR13G1 ORAOV1 CFH BTD TMEM14BZNF286A CDH8 SLC43A2 PATH HTR1A TAB1 PRH1 ACTG1P17 TLR3 NPRL2NO_MATCH_92 KRT31 GLMN KLRC4 LIPG BOD1 MSL3 PTK7 ADCY2 NEK8 AGFG1 TK2PNPO NOP58 CYTIP OR2G6 SSX2 GNPNAT1 HUNK TRAF3IP1 USP48 SDF4 FRMD5PRKACB CLEC4E C6orf141 TRIM21 ATP6V0B MAGEE1 TUBE1 FSCN2 ASB9 STK11LINC01561 DNAJC11 HIST2H2BF ST7L SAR1B DCTN6 RNF214 NOL12 HDHD2 BATFEYA2 ATP13A4 FAM81A MST1R NEK11 CLK4 TOR1AIP2 CDH17 CNNM2 CBARP PRKD1PNLIPRP3 SDHB GPER1 NPR2 PLEKHA8 NR2C2 SH3KBP1 HAS3 GDF9 ALDH1A1 ABCB8ADRA2A ETHE1 IGF2BP2 TCP10L2 NO_MATCH_18 RPS6KA5 LMNA FAM83A CDKL3 EYA3GPR89B DNAJC7 ACBD4 WWP1 CTTN FGF17 HLA-DOB MAPK13 XLOC_I2_014804C1orf162 NAT10 ZC3HC1 UGCG RTN2 VWA9 NR2C2 APH1A CNST HSPA9 PHAX CLK2RPA4 RMND5A ZNF341 AHCYL1 URGCP SLC22A1 PSME1 SLC46A3 NECTIN1 BTN3A3NAA38 KCNK2 COQ5 SMAD3 OR2B6 ADGRE3 MYLIP SOX14 RPL8 PLSCR3 PIGG OR51B5BCAM PHKG2 ALG1L NTRK3 CLEC14A ANAPC15 CMTM2 LARP4B SERF2 CPNE9 RNF32WIPI1 Hkdc1 ZSWIM2 SLC35G1 GPAT2 NPBWR2 BZW2 NO_MATCH_192 XLOC_I2_004840TBC1D23 HIP1R STK32C ZDHHC23 UTP14A FLOT1 ZCCHC9 LIX1L TPCN1NO_MATCH_119 EWSR1 CENPT MT1B XLOC_010217 SLC22A7 LPCAT4 IGLL5 MPP6TAGLN NSUN7 HEXIM2 PLK1 GPR4 FEZ1 HLA-DRB1 ADCK1 RAI1 NO_MATCH_94 CTSDPPP1R12C DRD2 P2RY10 CNDP1 CCNG2 MEF2A LAMTOR3 CALCA SLC28A1 ACTG1BPESC1 TMEM129 CREBRF ZNF486 TULP3 ZBTB1 TSNARE1 RCHY1 LONRF3 COTL1TOR3A SPATA2 KSR2 SMARCE1 HHAT GYPA IKBKE ATP6V1B1 CCDC17 SYBU HEATR9ERVK3-1 GLYR1 HIGD1A UGT1A10 PIK3R1 STX11 HID1 HAGHL COG3 EPHB3 NUDT15LYN SLC2A1 IL1RAPL2 GPR55 PRKCD BCAS1 FAM106CP GPR22 PRKAR1A TLR5C16orf92 EPHA4 NPY1R NCOA4 CDKN1A UGP2 NR2C1 GPR132 CPED1 OPN1MW2ANGPTL2 WDR18 RPAIN SPRTN RFWD2 REL LINC00852 PRUNE2 KCTD19 MAPT ADARB1NPHP1 PTGER3 EEF1B2 ATAD3B COQ8A ARHGAP20 GOLGA7 RSG1 C3orf20 PTGR2 BCANP2RY2 ADSSL1 DTNA ZNF490 ESRRG SEC22B MECR MAP3K8 C3AR1 GRPEL1 HTR3BKCNN4 GNL3 BTAF1 ZBTB45 COG4 C5AR2 MARS2 Ddx17 GABRR2 NLK USH1G MAP3K3CPSF7 PSEN2 EIF3L MKNK2 AKAP5 FZD9 KIAA1683 CDH13 PITRM1 POM121 TNFRSF17FKTN PANK3 PDPK1 PDLIM7 GCK CDKN2AIP MED31 GTF2A1L EPHB6 SNX4 TPO DMPKDCAF4 CTNS RMDN3 RBFA CD63 TUBGCP2 IKBKE PAK6 CEP44 SLC22A4 RBM24 BRS3IRAK3 APP PTGES3L-AARSD1 IFI6 CRY1 TPT1 C4BPB RORA CCDC14 NR1H2 TLDC1TAS1R3 BMPR1A PRKAA2 MARS FN3KRP NEUROD2 DNAJB4 SCYL3 MYH7 PSMD5 SCARB2GLDC PANK3 HMG20B CDK5RAP3 RTN4 ACAD9 DHX37 ZNF134 NO_MATCH_221 ILF2TGFBR2 NRBP1 PPARG VAMP3 ANXA1 NSA2 SLC35A1 SLC26A5 SERPINB13 REM2 FARSBCMKLR1 PGM2 FAM98A AMPD3 AK6 CD27 PPM1G LACC1 CHEK2 DAXX RHBDD1 MT1ARABGGTA MRPL47 LPIN3 CCDC122 ACVR1C TUFM CES1 HTR2C UGT1A1 LMO3 LRRTM1XLOC_I2_008203 SOAT1 PTPDC1 RTFDC1 RSPO3 CASP5 ASB6 GALK1 GNA15 ATXN7L3TSPEAR-AS2 LUC7L DNAJC3 EIF3J CDR2 XLOC_I2_004840 TMEM33 C1orf109PCDHB16 TNNI3K CXCR4 KPNA6 ADRA1D TTYH3 C14orf39 DAO DUPD1 PRKCE ST7FAM20B SOAT1 TRAF3IP2 TRIML2 DNAJB8 ACSM5 NPY5R SPTLC1 ESRRA VASP GCPRPF31 GRM4 ALPI ZCCHC7 SLC25A25 TSTA3 B4GALNT2 CDK14 GDI1 CDK19 CAPN2LGR4 PRKAG2 C1QL2 TMEM257 NRCAM ACKR2 ICMT NR2F1 STK19 ANXA1 CHRM1 AK5ADRA2C RPP21 FOXN2 GALK2 ABHD8 KCNRG JUNB ENTPD1 SLC26A1 SLC33A1 ENOPH1ERICH5 HOMER2 DENND6B GSK3B MIER2 MAPK4 TMEM121 COMMD5 SULF1 CHRNA9LTB4R2 ARHGEF3 LPL KMT5B SPDEF CDK18 TMIE CDHR3 AMBP ADGRE5 SLC6A20UGT1A4 SLC29A4 FERD3L RNF146 USMG5 Atr FYN ZSCAN9 EMD C1GALT1C1 GNL2PDLIM3 GK2 FIS1 KIAA0825 LIMK1 GRPR KATNA1 ZNF276 NEDD9 AGO3 PEX16NO_MATCH_242 MAPK9 RBMX USE1 STK25 DYNC2LI1 ENOSF1 MYBL1 ARHGAP26CSNK2A1 LCE4A TAS1R3 PRDX4 CBX7 ESR1 NT5C3A PPP1CA SLC39A3 PSMD3 OR2W1MELK ETNK1 TMEM204 NAT10 ZNF563 UGP2 GBP2 TKT SPRY2 LSM14A HTR2C PDE10AITK CERKL PRKAR1A MRPS27 GPR173 TOMM5 ZNF324B SEMA4B SPSB3 CHST11NO_MATCH_150 SRPK2 ALDH3B1 MEOX2 SYVN1 ASB3 UST PPP1R2 CALR ASIC4 ARSGXLOC_I2_009464 RHBDL1 ELMOD2 SUGCT ARPC1A GFOD2 LYPD6 ECE2 TPRA1 CXXC1TACR1 TSHR LRRC31 MRPS5 GNA15 XLOC_I2_004840 ULK4 CSNK1A1 HIRIP3 MFAP3RNASE2 SRSF12 ZNF101 SLU7 PCSK9 RCOR3 LY6E POC1A HNRNPK IRAK1 MAP3K13ACAA1 UTP14C FGF5 ARPP21 CCT3 ALG12 SHOX2 LIPG EVI2A CRCP ZBTB6 TFDP3LINC00115 ZNF821 TPMT MAPT CYP51A1 DDR2 SLC39A1 KIF16B BCAP31 GJB7KIAA1429 HLA-DPB1 HLA-DRB1 KISS1R KLHDC3 TMED8 BPHL RGS11 BIN2 NCEH1ELOVL2 HTR2B TRAF2 KIF1B MTA1 TRIM16L VMA21 ST6GALNAC3 BMX DPP7 SLC29A3PRPH2 ORAI1 PPIF POPDC2 FBXL5 ANKMY1 INPP5K NO_MATCH_164 TMEM209 RNF5JUN VKORC1 TAS2R38 DUOX1 FMO3 STK24 PTGER3 PRKCE IL20RA MRPL51 MTMR12NPR1 RABL6 KIAA1683 GPR137B PAK4 ZNF274 MCRS1 SUGP1 TRIM59 TMEM14A EYA1KCNG4 STS PAPSS1 RPS2 TF ZNF582 TMEM200A PHIP CCNA2 CEP72 NELL1 ANOS1TRAK2 NO_MATCH_235 DGUOK WNK1 NUDT8 GATA3 TMPO TRMT61B ZNF512 RORCALDH3A2 RHOT1 OPN4 MCAM KIR2DS4 PIWIL1 CINP GLB1L3 PCDHA9 CNP POLR3CCSH1 PHTF2 MVK AFF4 ZMAT1 ZNF250 TFRC TEX43 GALNT2 RIPK2 ICK PDCD2ZDHHC22 CREG2 SARAF ACAD11 YIPF5 PDCL2 KCNK1 KCNJ1 C15orf57 DNAJA4 STRCFCN1 MEIOC CAMK1 CDC25A ING3 WDR89 DDR2 CTAGE1 CDKL4 ABCF3 GPR12 DYRK2NDRG2 OXTR ASB17 GRAMD1B GPR107 LOXL3 PCMTD1 HRASLS ZNF219 FZD7 TBX18RAB11A NFATC1 POLR2F HRH1 NOB1 ACTL7B TNFSF13B GLIPR1L1 RGSL1 POC1BTMEM14B CCDC28B SAMM50 C12orf50 S1PR4 ZNF695 APOBEC3F SLC34A1 CDKN1AZNF416 TAS2R45 ZNF559 GPR4 TAL2 SLC35D1 P4HA3 ZNF2 CYP4V2 LRPAP1 IGF1RGPR88 GCKR TSGA10 FGFR2 PCDHB3 IRAK2 MAGEB10 TFB2M TUSC2 BCL6 BUD13STK26 B3GNT2 LACTB ID1 DCAF15 PRKCB PTDSS1 PGLYRP4 SMARCE1 SYT12 SULT4A1CEACAM8 AMT HTR6 ADAL HTRA4 ZBTB18 UBE2S RPL3 HNF4A GPBAR1 AUH HSP90AB1UBE2S RNASE6 MBNL2 SSTR1 GLYATL2 DFNA5 CLRN2 C12orf4 RPL15 HECTD2 CAMKVFRS3 TMBIM6 SLC9A3R2 MAP2K6 BMP15 C16orf58 SOX2 OR56B1 PCDHGC3 FAM13CMTG2 TSSK2 CD24 GNL2 DNAJA3 DENND1A TBCK KCNG1 RPS3 ADAMTS18 EPN3 BRCA1CRHR1 PLK3 LRP2BP CORO2B DFFA C17orf53 SLC4A1 SYCP3 MAPKAPK5 EEF2KPAPSS1 ZDHHC7 PTK2 CETP COX7B2 NFIB ABI1 SLC25A33 CDK4 PCDHGC5 VDAC2ARIH2 DDOST ZNF512B BRAF CCDC120 POU3F2 AFF4 DACH1 HSPB8 UVSSA APLNRXLOC_000477 AKR7A3 RPRD1A TGIF1 EIF3E ADORA1 GPR162 HBM RPS24 C16orf72NO_MATCH_178 SLC13A5 AKT3 XLOC_I2_004129 HIST1H2BN SLC9A1 MYRIP DRD1TCN1 TRIM28 PLXNA4 VSX2 ACP6 MLLT10 PDXK COX7C MAK16 LOC102724428 GATSL3NEUROD4 SLC2A13 CEP83 MRGPRX2 C6orf118 FAM71B DNAJC11 ZNF200 GPC5 CENPQACKR3 RFX2 BROX GPR161 TAGLN2 SLC34A2 CASQ2 SH3BP5L H2AFZ BRSK1 SIGLEC6NR1D2 PTCD1 REPIN1 DDB2 NBPF19 PFKL PPEF1 ZNF296 DENND6A MGLL S100A6NO_MATCH_222 ZZZ3 PTPN5 SPOCK3 RABGEF1 PXN GIT2 PDHA2 TFAP2A RPL3FLJ25758 CNPPD1 P2RY1 PAK5 GALNS ZNF133 LIMCH1 RAD23B TKTL2 TIMM23SIGLEC10 GNB4 UMODL1-AS1 GOT2 FLCN CLEC1A NDRG1 OR2F2 MCCC2 FCER1A CLK1NTS GALR3 NAP1L3 FGFR2 DNAJC28 CSNK1E ADORA1 OLFML2B CD55 SLC35B1 FANCGPLA2G12A UFD1L MARK2 WDR20 CFAP36 HSPA8 TRNT1 PTGIR CCDC86 UHMK1 TAAR1UNC93A EPS8L1 TBCC PRM1 EPHB2 GPR3 C1R XPC FDFT1 SSX5 ACVR2ANO_MATCH_199 C17orf102 CAMK2D TRPM8 SRSF10 GPLD1 FOXRED2 HEY1 ZCCHC12CTSV NEBL NO_MATCH_113 KRT81 EPHX1 STPG2 ABHD18 CDH16 TM4SF5 HDDC2 TOR1AC1orf228 FAF2 NO_MATCH_255 METTL16 RFPL2 SCTR LRRIQ1 LMBRD1 TTYH2 SFXN1SNX12 SULT6B1 PRKD3 HNRNPK NEK7 SBF2 NO_MATCH_115 UEVLD IWS1 PRTFDC1MYL6 DNAJC8 JADE1 TRABD ZBTB22 LIN7A KLHL34 GNB2 FLOT2 ARHGAP11B SOX10FAM217B GPR89A AAK1 P2RY2 PTPN2 C17orf75 ENPEP DCAKD EEF1E1 ACER3 GIPRGOLT1B OR12D3 MEDAG IRAK2 IP6K3 NO_MATCH_39 CD33 ZYX HNRNPDXLOC_I2_008259 CRAT ICMT SNX1 MTHFD2L RFTN1 PRKAA1 CACNB4 ZNF248 IKBIPUPB1 MPP7 BCCIP MAS1L CYP2W1 FIBP CEP55 DDIT4 HGF OR5K2 PXK SARS ATP5C1ZNF653 CCDC186 ARHGAP22 DCTN1 ZCRB1 DUSP22 GALR3 TTPAL DUS3L ESR2 NUDT9ATF6 MPP2 CPOX GAGE12B MID1 PAGE1 ITGA4 APPL1 RPS6KA4 PBK OR2C3 EZRATXN7L1 ARNTL2 USB1 TMEM200B CENPN FAM226A SLC7A8 AP3S1 NUDC HNRNPF SHPKMRPS25 CDC37L1 NELFCD CUL1 ABTB2 NOCT ERVFRD-1 CHEK2 HAS1 RASGRP4 PKD2L2TTLL2 PPP3CC PSMD7 SLC9A3R1 SLC18A1 GPR108 EPHA8 PPIE RAF1 CXCR5 CPLX1TACC1 ADGRE1 UBASH3B SFRP1 AKT3 TMEM115 SNX24 KIF25 ANKRD1 PTPRE CDK17GCK GOT1L1 TSPYL6 MLH1 SDCBP2 PMEL CYP20A1 SLC35F1 CBSL PLEKHG3 ZFP2MRPL46 GGPS1 P2RY12 HSD17B12 LATS1 CWF19L1 GRIN1 TEX28 TFDP2 STK33DDX19B SKA3 RUFY1 CDCA7L CCDC155 IRAK1 SLC13A5 PINX1 CSK LMNA DHPS KLKB1C10orf120 PCID2 CD53 PPIE POU2F1 AKT3 PROKR1 CCDC127 SLC43A1 ZNF114 PDK2TBC1D14 BRD3 TACSTD2 MCCC2 Prpf39 CYP4X1 TUBB1 IZUMO2 LOC102724428ETNPPL RAD17 KLHDC9 THEMIS PTGER3 ZNF85 FAM221B SYAP1 DYRK3 LMX1A TYRP1LAMP2 GUK1 HS3ST3B1 MAPK7 ASTE1 GPR161 LTV1 MORN4 Tardbp PARVG SIDT2IL23R HOXC4 TSGA13 PMPCB TCP11L2 MOXD1 LCK NDUFA7 INTS12 GPR107 OTUB2NO_MATCH_217 SLA RENBP EIF2AK4 TMEM199 P4HB PRLHR PRKCE DDX49 GMIPRSL24D1 ZNF132 S1PR5 ZNF341 TGFB1 PRAMEF15 TPH2 NAGS COMMD2 CFAP100PSMB4 TBR1 MICA DUSP10 MAP2K7 ACKR3 YWHAE RAP1GDS1 CXCL11 CLEC4MSLC16A13 SVOP ITPRIPL2 IL10RA ASB7 AGK SLC25A1 HPS6 BCL7A HTR1B SERBP1PRR30 AVPR1A NROB1 LIAS C1QTNF6 IL10 CSGALNACT2 CNTN5 OSBP PHC2 ACADSBSTK38L MED21 TMEM139 SLC4A8 PPP1R14C AMDHD1 DVL1 NO_MATCH_265 CEP170BGID8 CCDC121 C5orf34 JPH3 DHDH NME7 SPPL3 GPR45 PLXDC2 ZBTB49 CPA5 EDIL3KCND1 CCDC114 RAD51D ACER2 TRAPPC5 MRPS7 MRPL32 ANXA2 ACTR3B BEGAINATMIN PPA2 CIRBP RPS6KL1 KLHL40 LIX1 SAFB2 RCL1 ATIC LBHD1 BIRC8 DKK1NO_MATCH_20 ADGRG5 DNAJB14 LGALS8 CCND1 MEX3B PSTPIP2 OPN1MW2 PTMASLCO2A1 CYB561 BRSK2 VDAC1 ABLIM1 LMBR1L MRPL39 FAM221B PSMA4 FGFR1OP2DMP1 MGAT4B TEKT3 IL17RE PAK5 TRH ADAM32 EYA3 CTNNA3 CDK7 LOC107984086MALSU1 GTF2F1 OR6C1 RACGAP1 PPARD GRM6 PRC1 TOX4 FN3K ENO1 CAMK2D GUCA2BGUSB MAPT PLPP5 C10orf82 GTPBP3 AHCY UXS1 CD83 LEPROTL1 RSBN1 LRRC27STK25 PKIG VAC14 TBC1D23 MRFAP1L1 IKBKB ZMYM5 GPS1 PRKCI SMAD2 ACOT7ZRSR2 GPR52 EPS8L2 GCK DFFB C15orf41 CSNK1G3 DCAF4L2 ZNF566XLOC_I2_007271 ROM1 PTH1R ARFIP2 ADPRH TRAK1 PAK6 GDF5 CLPTM1 WEE1 CECR1FAM151A HGFAC GYS1 DCLRE1B CD28 TANGO6 STX10 CUTC RNASE9 HSF1 GBA3 TEKCCND2 GTPBP2 SSC4D REPS1 PTEN STK17B RDH12 KLF12 SIRT7 TCAP HERPUD2DEFA6 ASIC4 NO_MATCH_276 MAGT1 SIPA1L2 CYB561D2 NLRX1 PGAP3 ARL15 PRSS1VIPAS39 TMC4 KIF6 EBNA1BP2 SMYD3 FAXC RNF168 RPL13A PGD RPL36AL ELOVL1KLF4 GPR135 TRAP1 MAPK13 SH3YL1 DNAJB9 GRK3 U2SURP NEK2 DDHD1 EEPD1RNF217 DCUN1D2 ADRB2 TAS2R1 SARS2 SLC22A23 TKTL1 CALCOCO2 PRRG1 SPACA1ZNF3 VDR N6AMT1 MAP3K2 PITX2 GKAP1 G6PC ZBTB38 LOC102724334 NQO2 WDR62ACSBG1 YY1 ARHGAP18 NO_MATCH_252 CLEC1OA CSNK2A1 NME7 LINGO4 C10orf88WWTR1 CRAMP1 DSTYK FGF7 WNT7A OVOL1 GATAD2B RABL2B BFSP2 PBK CLK2 PDAP1TFB1M PSMC2 TMPRSS2 CTBP1 UBE2D3 CCDC36 GPR26 CCDC105 DEGS1 BTN3A1 HDAC1ALDH8A1 RAC1 CSNK1G1 RPL3 ECEL1 PTAFR HUNK ACVR2B AKR1C2 OR51E2 KLF2HHIPL2 RASSF3 PABPC5 FAM3A P2RY1 FZD9 FRMD1 PDHX RNF113A RNF180 PRR23BSULT1E1 MMP8 TMEM134 EOGT GNAS SRC TWF1 ZNF548 LAX1 FRK PRKCB EMC2 ENSATCF3 DACT3 MIR650 THRB KIF24 GPR78 THRB TMTC4 AAR2 TRIB2 CHRM1 RIN2 SF1PTGER3 FSCN2 PLG PPP2R2B MIP HLA-A AGTR1 DIDO1 SERPINB11 TGFBR1 COL21A1MAP3K8 CCR4 NO_MATCH_143 CHAF1B SDCBP MAN1B1 GRB2 SHC1 DNAJA2 STMN2SETMAR S1PR1 WASF2 CA4 GRAMD1C EDDM3A SMAP1 NAPB ARHGAP15 ARHGEF6 TESK1ARSK XLOC_I2_004840 UQCC1 CLK2 IFNA4 PDHB HLA-DQB2 SSTR4 COQ8BNo_MATCH_127 TSSK2 FAAP100 DRC3 PSG1 MICAL2 KRBoX4 ICA1 IRF2 RARA EHMT2ANXA7 SLC22A13 LZTFL1 NO_MATCH_173 TSHB KRT6A ZNF71 OR51E2 BCL7C PTBP1UBQLNL NECTIN2 TMEM161A GLE1 IL7R LOC554223 GTF3C5 PDGFD SNAPC2 METTL14NMRAL1 PLXNB2 SCNN1G CBWD5 NUP88 IRAK3 SNX16 SYTL3 DYRK2 FGFR2 EIF2AK2SPA17 MEI1 RIPK3 EZH1 ADAT1 LRRC8B STAT6 TANK ASNS UPP2 ZNF98 NEK6 NTSR1LZIC C14orf37 TRIT1 PNOC GIPC2 EVA1A C4orf47 CLEC4F TBC1D25 TMEM79CBFA2T2 PRODH PGRMC2 ZCCHC10 OR7A17 MAP4 PPAN PDLIM7 FOS LINGO1 PKN1HTR6 NR5A2 HEBP2 NPM1 PIGF WTAP PPFIA4 ZNF32 TAS2R39 WDR88 CEP57SLC22A24 SCO2 DNAJA4 FBXo16 TGDS HIST1H4H TES PGM3 CCDC142 ZNF30 FAM153ALIMK2 RORB SLC1A7 HAL FMO1 THAP2 PTGES3 LRCH1 CES3 ZNF98 NAP1L2 CAMK4SLC35F1 SLC52A1 ENOX2 TAS2R7 TSPEAR GBAS SORT1 HARBI1 GALK2 PDLIM5 MAPTATP1B3 COPS2 FBP2 SLC25A38 DPEP3 ESRRB GPR176 TMEM236 UBL3 PDK3 GZMMBCAN C6orf223 SLC25A18 PoLR2G FANK1 XLOC_I2_006014 ADRA2C CCNH SEC31BTMCO3 ETV1 ZNF285 GPR183 GEM WDYHV1 CXCR1 P2RY8 UPK3B PPM1D NUP160HNRNPCL2 ZNF689 RBM4 ADH5 GAL3ST2 FGFRL1 TMC8 SLC52A1 COQ3 SUV39H1 RoS1ATG13 STAMBP PRR7 TRMO PPAN SEC14L1 SCAMP2 FZD10 RRAD GOLGA8B SAMD4ANDUFV3 ZBTB44 RFC5 GAPT KIFAP3 TXNRD1 NLGN4Y NO_MATCH_59 XLOC_I2_015194GPD1 SPAM1 NME6 ACKR3 CFAP53 SCTR YIF1B PPP1R15A TMSB4Y MRPL38 GALK1CNOT7 TMEM184A ITPK1 PRICKLE1 NDUFA9 NR2F1 NEFM IRAK3 WDR27 ACTL6A ATG4ASMYD2 ZKSCAN1 NO_MATCH_70 DCPS ARAF RNF5 HSPB8 SCOC QRSL1 EIF4A3 PTGIRSH3YL1 KCNJ13 OLAH GCLC AIFM2 NELFE MTERF3 LRMP CGGBP1 FAM98C TAAR3RILPL2 HLA-DRB3 CCR3 RIMKLB TTLL9 C8orf37 GJA3 DLGAP1-AS1 DRD1 CAMK1DSRSF3 SMCHD1 CKM HLA-DRB1 SLC25A11 HOXB6 TMEM101 KIF1BP SEMG1 ARAFALDH3A1 CCDC138 FMR1NB NOLC1 B4GALT4 TNFAIP6 EHD1 MESP1 PAX8 LCE3C RBM23NR5A1 SRPK3 EGFL6 KBTBD7 PHKG1 NO_MATCH_32 SSX2 FBXL19 BTBD18 PROSCFAM71D GPRC5A XLOC_005142 NR2F6 ARID3B CTBP2 XLOC_I2_015600 PRKAR1BPNMA1 PENK GNAZ SFRP2 RAB23 NO_MATCH_243 CXCL13 PLEKHB2 MPP1 EGFL8MTERF1 TMEM263 LRTM2 RABEPK PDGFRL ERVW-1 NT5C3B NAPSA ABHD5 RIMBP3 CCT7CMSS1 KL NADK2 SUMF2 MAGIX JMJD6 ETV7 ZKSCAN8 KERA AGFG2 FAM117BC14orf79 CPEB4 SNRPC HAGHL F2R APOA1 LIMK2 CDCA7 LRRC36 IRAK3 SPANXA1NO_MATCH_107 ELMOD3 GINS1 STAT5B CCDC96 ADAP2 DEPDC5 CRY2 CNKSR1 PIGKIDO1 CPA1 MYLK2 ST3GAL3 SHC1 L3HYPDH PIF1 SLC25A44 FBXL12 XRCC4 RPS6KA4LONP2 GPN2 FBXL3 ZNF772 EEF1G LECT2 MPP2 SSTR3 FAM133A NKD2 ESM1 CCDC65EIF3E SMARCB1 CCDC6 UPF3A GLP1R BRAF C8B PDS5B EXD1 CHN1 FBLN5 ATG14TNFRSF10D CCAR2 NR4A2 ETNK2 CAMKK2 CCDC102A RPL13 GRPR CD79A FFAR3PPP1CB TMEM206 CCRL2 OSGIN1 EBAG9 VBP1 ACTRT1 MRGPRX1 ARMC9 ENO3 HM13TERF2IP RNF220 RNF8 Prkd2 MIR4697HG SSTR3 NR1H2 HIST1H4F SLC40A1 IL22RA1CELA3A SERPINB11 EPHX4 PNKP HINFP LAPTM5 UBE2D3 P2RY8 CD1E CDX2 VRK1FOXD4L6 SLC35B3 EVA1C CRY2 CAPNS1 BYSL PSAT1 AHCYL1 C5AR1 RPAIN NXF5STRN3 SLC39A6 C16orf46 ROR1 ATP6V0D1 CXorf66 MYLK3 PRKAA1 TRIM52 MTFR2MAGEB4 MTFMT LINC01555 CANT1 LOC100653049 TEX101 PDGFRB BTN3A3 RASL11BNMUR2 CD8A C10orf107 NTRK1 DCT SFXN5 PSMG2 SMARCD2 ZNF414 OR6W1P STK25MMP7 CD151 MYOZ2 PIGQ GNAL PRKCB CSNK2A2 KRR1 KCNG1 CBWD2 CLASP1 EIF2AK1LNX1 CSNK1E SWAP70 MDH2 DHRS4L2 POLE3 CCER1 SSX3 VEGFA CDK5RAP1 GPR87PILRB COMMD3 LSM3 HLA-E ZNF230 NR1I2 KRR1 CLECL1 HLA-B DAZ2 S1PR2 PRKCZCYSLTR2 NDUFA12 XLOC_011321 EXOSC9 CRISPLD1 MUC15 AGO1 PDIA4 KCNG4 DSCR3PUF60 ZNF212 APH1A BTBD8 SNAP91 TXNDC11 NFYA TAF8 BRD3 VRK2 FAM153BITGB7 KCTD6 BRAF PDIA6 PRKCG DHDDS TRIB1 POLA2 CLU PLXNA4 WDR54 INSL5FOXJ2 NBPF8 SLC45A3 SFR1 FBXL15 UNC50 ONECUT1 MPP4 TBC1D31 EIF4A2 HMGB1ASH2L DVL2 KISS1R KIAA1147 TSSK6 CCDC137 FHL5 PDK4 ASPA OSGEP RPH3ALNUDCD3 ZNF816 SLC45A2 BRAF CACNB3 CBFA2T2 EPHA3 RABGAP1L RBM4B GDF10S1PR2 ALOX5AP APOA5 NUDT18 GKAP1 LETMD1 CYP3A7 AP1M2 EEF2KMT TSGA10IPTMEM192 IDS POTEB3 C8orf44 SELPLG CDK1 TRIB2 FCHO1 BTBD9 TRAIP SP8LGALS3 DCLRE1C PCSK9 KCNK9 UCK1 TNFAIP2 QRFPR HDAC1 CLDN7 LRRC15 ELF2HPCAL4 FAXC B4GALT1 MS4A12 WNK1 LRRC28 STRADA KCND3 SHTN1 TAPBPL PRELPHIPK2 SLC29A3 MORF4L1 TBC1D28 KCNJ5 PLPPR1 TMC6 SLC25A23 DDR2 TMEM207IQCF2 PYROXD2 LARP4 CSRNP2 ST6GALNAC6 HLX EIF3E HS6ST2 ACTA1 ATMRALGAPA2 MS4A13 TARP MKNK2 TUBG1 FDXR ERF CPZ BHMT2 TXNIP NME5 CAV3BEND3 UMPS ASCC1 GPR19 TIGD3 FAM3B FRMD6 CCDC96 TRIP11 TPRA1 STARD3DAPK2 GPR19 F2RL3 SSH2 CETN1 CHAT MPV17 TBC1D7 DMRTA1 SLC29A4 TEX12UBE2A ZNF774 USP22 SLC37A4 MKS1 STARD3 CGB8 OR1Q1 TBCK ABCC11 SIAH1ACVR2B SPINK1 KCNQ2 RP2 CSNK1D DBH ELOVL6 NO_MATCH_100 NUP210P1 ZBP1FAM188A GPR174 GOLGA4 ALKBH1 LMBR1 PIGR GRM8 PPP2CB MADCAM1 PARVA LAMPlOSTF1 IL13 TRIP6 AKT1 NIPAL1 CALHM2 ZMAT2 KCNK13 TASP1 HLA-DRB5 VASH2IGIP PRAMEF10 NEK11 OR5AK2 HOXA3 STK17A LCORL TNK1 GDF3 MRGPRG SERPINI2LCMT2 GIMAP7 DENND2D CMAS TSHZ3 TRIM62 ERMP1 PSMA1 LYZL2 WARS2 HNRNPLLOPN3 RPL19 GPR157 ZNF354C C1orf106 SPG7 NDRG2 FAM127C SPATA1 SELENOFMICU1 ENPP6 SPATA4 DYRK2 FKBP3 PIP4K2A PPARD EIF2B4 NFU1 MFF TNK1 IFRD2HOMER3 PPP1R12B GCAT RBM34 IL12B GABRA5 GCNT2 GCSAML TRAF1 CDKN3 ARFRP1GOLGA6L9 ACTG2 GABARAPL2 ZSCAN22 HPD SALL4 HTR5A FOXP4 PNLIPRP2 CNNM1TPPP3 THSD4 PRKCZ PCBP3 NAPA PSEN1 GRB2 Fgd6 TP53I11 OPRK1 NAPG CCDC7NOXA1 DMBT1 RBM3 RIOK1 ZNF587 P2RY8 RSRC2 NR1H4 MAP2K3 SSTR4 ARHGAP36AGXT TGM3 KLK3 DNAJC10 RRN3 CSNK1G3 PGLYRP3 PID1 GDA TMPRSS4 ACSM5 AKT3GPR84 MYL6 MS4A7 DIRC2 TRIM60 GPR21 GCNT3 BTG1 PTPN2 PRKCA FAM193B PLAUCPA3 NUFIP1 BRMS1 TMED6 ADSS MLPH KYAT3 HMCES PHACTR2 TMPRSS11E C3orf36RIC8A FEZF2 DENND1B PGK2 OR1E2 OR2T2 CHRM2 GPR17 GRK2 TMLHE GRM4 CPNE7LPAR6 HTR3B Atp11b SGK1 PANX1 APTX CDK16 KCNC4 NPY5R VPS4B FOXP2 KIR3DL1PRKCA CLEC1B CA10 CHRM3 GPR119 SLC39A11 ZNF252P-AS1 ALDH3B2 MELK Srgap3EMC7 SLC35D3 RTCA FNTB NUP58 TTC23 NUP85 Laptm4b MATK TMEM45B SNAI1LPAR3 GPN2 LGMN FLJ37201 ITGB1BP2 RPL32 RPL35A RPL6 Rnf150 NIM1K CCDC12SPATA7 MOGS PYCR1 CHRNA3 RIC3 DNAL1 ZNF155 COX11 IP6K2 RTP4 TSPY10 CXCR6ASB8 OPN4 GPC6 CSPP1 DHRS7B ABCA8 DPAGT1 RAB3A GPATCH2L NFIL3 FANCM NFICMLYCD GPR141 FAM234A TCN2 LOC105379861 ACAD10 RWDD2A GNB2 LOC55338 ALDOASNUPN CXorf67 RAET1E CEP70 GRM4 YWHAB Rasl10a SYF2 NUFIP2 GRM3 CCDC13CHRNA3 EXD2 LYZL4 NAMPT CHMP4C AHCY GBP7 PGRMC1 TBRG4 GBP7 IL21 ENO2CCR1 TMEM9 CETP ADCYAP1R1 PHKG2 SMPD3 SYT2 PCLO DECR1 CHSY3 TWF1 FAM196ANDUFA5 SSTR5 PRLHR GPA33 ANKZF1 PI4K2A FEZF1 CNIH1 HTR3C EDNRA CSNK1G1REEP4 OSBPL2 SPRY1 AMZ1 WIPI2 GCGR SLC11A1 TKTL1 ATP5F1 HERPUD1 MURCROGDI HOMER3 GPR15 SPATA12 CTGF CCDC17 ZDHHC16 CD209 DIXDC1 SCGB1D1 PLAUHSD17B2 ZNF517 DMPK FERMT3 XLOC_007477 ZFP36L1 IER2 DYX1C1 PMM1 C3orf62GINS2 CASP7 CXorf40A APOC3 CYP24A1 BEX5 GCGR HEXA LRRC32 UBE2Q2 IRGMPIH1D1 STMN3 KCNAB2 UBTD1 NPRL3 ANKS1B ILVBL DTX3 TWF2 PPIB IL26 VWC2LHMX2 C9orf106 RARS2 ACRV1 TRAM2 CHUK ADRA2B TAF1D DYNC2LI1 MGME1 PDGFRLPIAS4 XXYLT1 ARL6IP4 DVL2 SLC5A8 NO_MATCH_34 EPN3 ATP6V1E2 42987 AKR7A3UXT ZPBP LSP1P3 PSMA4 NOL10 DNAJC17 IYD HDAC3 DYRK4 MAPT LCMT1 P2RY6NO_MATCH_207 ARHGEF19 CYC1 PACSIN2 ESRRG SNF8 TMEM43 ATP5G1 RPS6KB2LSMEM1 TTC7A DCAF11 CYP2B6 ARRB2 Fam122a KAZN LAG3 RND2 HEMGN LRRC74AFBF1 CCRL2 FRA10AC1 BIN3 VAMP5 RORB COQ8A SFRP4 PFKFB3 MT1H NR4A1 WDR83NAGK LINC01600 ATF6B TTK GUCD1 CLYBL FBXO39 OR10J5 NEFL SRSF9 TMEM27NEUROD6 PPIL4 DCANP1 RPH3A TLE6 PAICS MTCH2 P4HB LDLRAP1 MYCT1 STBD1CASS4 ATP5S RAB6A NAT9 TRIM9 PITPNB BCAS1 ATG16L1 PHB2 LILRB5 EDNRB DDI1TBC1D13 ALDH1L1 SSMEM1 HHLA3 PLBD1 ZNF747 YAF2 KCNQ1 HMGN1 MFSD7 RPS6KL1AGER PRKAG3 C2orf49 GMPR2 TOM1L2 NOTCH2NL VNN2 TMEM50B AFMID NO_MATCH_47KANSL1 MLF1 GGTLC1 RPL14 KIF16B WASF2 MED11 PRCC NO_MATCH_257 COX4I1STAP1 CLEC3B ZBTB43 ADRB3 KLF3 SLC37A2 IL10RA PACRG VPS4A YWHAG SLC25A6TUBB4A C1orf127 PATZ1 ERLIN1 ZNF720 RAD23A RARRES3 TAF7L HTR1D SLC18A1GSK3A DYRK2 STRADA NTF4 CHST13 ADRB1 ZNF75D KLHL32 ARC WBSCR22 SIRPDGABRD DEGS2 BSND NIF3L1 TRAPPC13 MSC TUBA4A TRMT44 P4HA3 WNT16 ESRINT5DC1 SENP1 SERBP1 GJB4 RAD51D GSK3A PFKP SPATA1 TAAR5 PSMD3 TNFSF8C16orf78 YES1 RCN2 TRIM50 C17orf51 XLOC_002741 MTNR1A GHRHR CCR6 PPP2CAEGR2 NOTUM 42984 PLPP2 THAP4 RIBC2 ABI2 C2orf73 RIMBP2 PELI3 NUP62 PIGCGBGT1 FIBCD1 ANKRD26P1 OLR1 DDX39B C19orf47 FNIP1 SMAD4 HAX1LOC100128554 EEF1B2 USP39 PSMC1 GPRC5C HLA-F GCK MTNR1B ANKRD29 RPS14GPAA1 CHIT1 PDE1C MARK2 NPY2R PAK6 NATD1 OXSR1 SEC22A TXN2 AMN1 C8orf34DNAJC15 XPNPEP3 SSNA1 CAMK2B NO_MATCH_224 CXorf58 FRMD8 C6orf89 CYP7B1LRRC25 CDK18 COG8 LAMP3 OTULIN KCTD8 OR1A2 SYT17 DGCR2 SRSF7 VPS53 IFIT3NCR3 HARS TRAPPC10 SNX15 ACVRL1 RAB24 SYT9 DTL ALDH18A1 FGD4 RASGEF1ASIGLEC7 CPLX2 HSD17B12 MAPT XLOC_I2_005687 CDK20 SEMG2 PIK3R3 LARP6GATAD2A OXT EYA4 PTPRR CDK5R1 GABPB1 XLOC_012729 RAB11FIP4 GPR18 NSMFLIN7B CCDC102B PHLDB3 NDUFB6 SLC25A42 ROR2 SLC2A14 HLA-DPB1 ACBD5 TRIM2B9D2 NO_MATCH_55 TRA2A PPP1R15B DHRS13 C15orf48 RNF14 P2RY1 NR1I3HIST1H2BD AKR1A1 RIMKLA MAP2K3 XLOC_001087 CD300A MSMB PSTPIP1 AGO2 BFARMUS81 PODN DGKA POLG2 NPM1 GNA11 FA2H PSG6 PGK1 ADORA2A FFAR2 CALML4CRTAP GMPPA PHB BARX1 CCR10 PCDHB7 CCDC185 FAM189B C20orf96 LACTB2 DHODHHCCS STX4 EPB41L4A ZNF333 FANCE RIPPLY1 ARRB2 PNPLA2 ARMC6 SENP8 GTF3C4TUBB2A TUBB4B XLOC_I2_014048 C6orf222 OTUB1 PCBP1 TYRO3 MFSD8 CAMK1GPFKFB1 SMOX CXCR3 MASP1 KYAT3 MAGEE2 CYP4B1 KRT18P55 TYMSOS PPARG MAPK11NPY MRPL13 TUBA1C DLK1 AVIL PSRC1 SPIRE2 ADIPOR2 TMOD1 LOC107984064CDK20 SPATA5L1 CAMK1 BIVM SLC23A2 CAPG ALDH1L2 TAS2R8 FZD5 BHMT GRIK2KCNC4 TNS4 ACP7 CCR9 SET DCUN1D1 IKZF1 ZNF26 AAGAB LOC107986810 KCTD4HNF4A AQP1 PGD UBE2M ACSL6 CD59 PHYH FLVCR2 BNIP3L C9orf153 SLX1B GPR182ZP2 KRT20 LCN10 ADSS PRKX SETD9 PLIN5 PPAT KATNAL2 USP15 CACNG5 HLA-GGAST ACOT1 AK3 OOSP2 ASB16-AS1 CSNK1G3 AEN PLPPR2 MKNK1 RNF125 TPMT RFX5CNGA3 CENPK LUC7L2 TCTN1 CYP46A1 SEMA4B CORO2A KHK SRPK2 NFAM1 MRM1CDC73 ASTL CNIH4 COQ8B MMP14 FAM216A METTL7A IL20 TACR2 PRKAB1 MC2RCELF5 C7orf31 CDK2 GNAI2 EMILIN3 CNPY4 KCNMB1 SLC2A12 TEX35 TP73 SNRPD2CCDC181 CCL28 RHPN1-AS1 TEX29 CCT4 CHRM5 Vps16 XLOC_I2_005179XLOC_013643 CHMP5 COCH C16orf71 ACADL SPPL2B CDK2 ATF1 P2RX1 ZNF446SUGP2 ZKSCAN8 MITF MAMDC2 MREG HTR5A FGD2 HYI WDR18 CTSD METTL10 RWDD2BCAMK1D PTGER3 CHRNB3 MLLT6 PLEKHA1 PIP5K1A CYP4A22 LTB4R VWC2 STAU2 NXT1UBXN4 ZNF843 PBX3 CLEC2B S1PR5 C5orf51 SUN3 PMPCA NAPSA ANKRD46 SULT1B1LRRC41 GPR68 RNF128 CHIA STIM2 SLC10A6 TNFSF18 RALA PDE4D PTGER1 MKL2SLC13A5 Pds5a SLC30A5 CCR9 HSCB SLC6A11 PI4KB GYG2 PRM2 VDAC3 TACR1OR2T10 FBXO21 INTS4P1 SMPD4 FUT8 GABRQ CYSLTR2 POMGNT1 MAP3K15 SEMA4BTHG1L CBS FAHD2A ZBBX LGALS13 STK38L CDHR4 FMNL1 SOD2 UGT3A1 PRRC1 RGS9STK26 HRH2 SLC29A2 CXorf38 HIGD1A GPR119 CRIP1 SCD TADA3 PINK1 RNF126HIST2H4A NO_MATCH_182 POTEB3 CD247 CAPG TGOLN2 ACSBG1 NECAB2 TAS2R5MOCS2 PPP2CA LPAR5 ABT1 JPH4 DAP3 TSSK1B TXNDC17 IL17RD CCDC90B WASF3P2RY12 PRKD2 MIOX CD300LF UCMA CNP PCAT4 FNDC11 AMBN PCYT1B KCNK5 DNM1NO_MATCH_111 PYCR2 IRF9 PAN3 PELO GIPR SSX2 TDP2 SPATS2L SNX8 RBBP7KLK13 BAD SP2 SLAIN2 SPATC1L CRYL1 HMGN1 GPX2 MYL10 PRKAA1 CDK15 ANAPC15WEE1 STK32B SNX32 TRIM39 CHRNB4 C16orf59 GPR37 SYT6 SLC13A5 KAT2A CDKN1BGADD45G PCK2 AGTR1 HSPB7 MON1B C8orf86 DRG1 LCMT1 SYTL1 DUSP10 SKP1 NEK6TMEM30B MSANTD2 ACKR2 PRPF18 PBXIP1 ZAP70 DUSP6 ROR2 BMP3 SLAMF6 BTF3SNRPA NAA40 DYRK2 HIST2H2BE PPARD RSPH9 KCTD5 CCDC47 KEL MIF4GD S1PR1MOXD1 SNPH RPL37A SCN1B POLR2I VASH1 SNRNP35 MFSD4A SOHLH1 C21orf59KRTAP12-1 CDHR5 FOXI1 SMOC1 HNRNPH2 AMOTL2 RIOK1 HOMEZ TMEM266 MTX2LRRC4 GNAT2 TVP23C SERPINE2 STN1 MPI ISCU VEGFC TBC1D22B H2AFY UBE2E2LYPLAL1 CXCL1 GAS7 RNF13 CCRL2 TRIM13 PIN4 NME1 RRAGA IGSF10 METAP1VGLL3 KRT38 SPAST ABHD13 ZBTB42 FNTA SSC5D SGK2 HMGN3 CDCP1 IP6K1 CST1PSMD9 PPP2R3B NEK2 CDK1 RAB3C FDX1 DMKN BRWD1 ARL13B CXCR4 CATSPER4KCNN1 THAP11 CELA2B CDCA3 SLC37A2 DENND1B SLC2A4 CCDC174 TRIM28 HSD17B7GPR21 TRMT112 CYP2J2 SQSTM1 MRPS26 GABRA3 PHF13 RCN1 OXA1L CD79B GNAI3KRTAP9-6 LRRC4C TMED5 LYRM1 POP5 NR2E1 NDUFA10 MARVELD2 PDCL SGO2 KCNA7PTDSS1 CCNB1IP1 RIPK3 NEUROD1 CXorf56 CCL19 SLC39A5 NKAPL ARL4D TRIB1THAP4 OR2T4 CKMT2 HNF4G FUNDC1 SMAD7 RNF181 LCE1B CLCN2 ADORA2A HRGSTMN1 ZFYVE19 Lztr1 HAVCR2 HSPBP1 FAM76A WBSCR22 EYA2 OR5L1 SERPINB4WSB2 VSIG8 EFHD1 EXOSC5 CSNK1A1L RNH1 OPN5 DNAJA3 PHLDA3 NR1H3 AP2M1UBA7 TMEM171 VASH1 LGALS8-AS1 MAK PRDM5 CKMT1A AKT1 KLKB1 SCAMP1 FAM209BP2RY14 TFF2 LYPD1 ZBTB24 PCYT2 DNAJC1 TRPT1 HP1BP3 SGPP2 TRIM17 PIGMANXA9 RPS10 ABHD16A CDK6 P2RX2 RGS8 EDN3 EFNA5 ADCYAP1R1 TSPAN14TNFRSF10A MINPP1 KRT72 MYL12A PPIA GIMAP4 ATG9A FOXG1 KIR3DS1 RPS20 DOK6AKNAD1 CFDP1 MFSD2A IL6R ZAP70 RHOJ PHKG1 SELENOT NR1H4 PPID SYNPRLOC107984065 RMDN2 GABPB1 GEMIN8 UTS2R ABCA11P ICAM1 TSSK3 CA9 PDE4DTYW5 FN1 CATSPERD FLRT1 CD2BP2 RBM33 PPP2R1A ARSI CIDEC ADRB2 GABPB2LNPK CRHR1 BAIAP2L2 MAP2 CAPNS1 TSSK2 TMEM176A DPEP2 GSTA2 IQCF3 PARP16AVPR1A RP2 BRF2 TAAR9 PANK2 MSX2 TTYH2 MLNR PHC3 DECR2 MSANTD3 TPM1BTN3A3 PCED1A IMPDH2 CSNK1D INTS4P1 SNRPG GSK3B TAS2R38 DCTN1 RANBP3LPELI2 SSX4 RSL24D1 GPER1 CSF1R PANK3 CPNE1 CDK1 GORAB LPAR2 TNFSF9LZTFL1 BCL6B CEP41 REEP6 KCNC4 DHFR SPC24 SLC39A7 VSTM2A NCALD RNF175KCNMA1 IL4 P4HA2 UBR2 CAPG SEPHS2 HAUS7 PMP2 RAB43 MTFR1 ADCK5 SLC47A2OR5M8 LDHD SMPD2 CCDC34 CYP2C9 FOPNL CXCR6 PI16 ZNF221 CS ATF4 POLR2HTESPA1 GPR25 XLOC_014209 PHF7 LINC00467 DMKN C9orf78 P2RY13 B4GALT2SLC25A32 ITGA9 BUB3 KHK TEN1 MMAA LCTL PGRMC2 ARHGAP29 ATG10 TMEM95CCKBR LAMA4 FABP1 TMEM179B Pkdcc AP1AR CAMK1G DLX2 TUBAL3 RPL28 ITM2CMIF CD99 ZSCAN5A DPMI DAZ3 MRPL12 NXPE1 KCNA3 GALNT5 THUMPD1 OLFML2ANFIX CMBL GTF3C2 ADCYAP1 SURF6 XLOC_011808 CSNK1A1 MUSK OR2F1 KLHL7 KRT8SLC39A8 RAB29 AIF1 PRR20A AIM1L MTHFD2 SCHIP1 CX3CR1 NIM1K SPATA2LPIP4K2C SS18L1 POMK PCYT1A SNX17 DPYS PPP2CB S1PR3 MRGPRD GPRC5B DHRS1CCT8L2 COX7B NGB CRX MRM3 CIB1 TOMM20L AMHR2 AZIN2 STC2 OR52I2 NUP43FMO9P MSX1 TRHR AK5 NO_MATCH_251 MORN3 H2AFX ADORA2B FBXW11 GGACT HOMER3GHRHR ODF3 PDXK CPA5 DUSP26 ETNK2 TSNARE1 GPN3 BAG4 PPIL1 SNRPD2P2 NPY5RATG13 ATP6AP1 GCNT1 ATAD3B POLD2 SIVA1 MAPK15 CHRM4 RELB GATA2 NOL7 SYT5TRIM49 XLOC_I2_006624 RRP36 DCLK3 KIFC1 PRSS23 PIAS3 AEN VRK3 OPN1SWCCNI2 EIF2AK2 GALNT1 HIST1H4B XLOC_I2_001669 CIB4 NPBWR1 PPCDC STK17BARL2 GPR142 C7orf69 42979 NIPBL MGRN1 HTR3E PTGER4 C1orf87 RDM1 TRPM8CRACR2A TRIM69 MAST2 ARFGAP1 MB21D1 SLC24A5 TREML1 RSL24D1 FTMT CORO1AFERMT1 RARA NME4 XLOC_I2_004840 SLC16A14 SMR3B GFER CCDC134 FA2H TMOD3BCKDK C1orf43 SRPRA CERS6 ALG3 IL2 F2RL3 PRR15L DYNC2LI1 NO_MATCH_180TCTEX1D4 GPR37 MAP3K12 MRPS31 HAPLN4 PRRT2 MAPK9 LGALS9B PHF23 CALML5CMC2 SP2 CPA2 HSD17B11 PHC1 ATP6V1G1 CAMKK2 CLDN10 SLC6A13 NDUFS7 PEX13CCDC92 CD1D PSMA1 LPAR2 RBM42 C19orf73 DCTPP1 CPOX DUS1L GPR156 NONOXLOC_I2_000791 MRPL2 MAK TSPAN31 FAM9B 42795 BCL10 CSH2 SLC36A2 EIF3HSLA2 TMEM98 MBLAC1 SCARA5 LOC105379861 PRPF40A TNNC1 DCUN1D4 FOSL2 TKTKCNA5 PRKCZ NAALAD2 SERPINB2 APOA2 LPL SHMT2 TAB1 PEMT PHTF2 LRRC3BSYNGR2 TMEM230 KRT80 OXGR1 HEPACAM2 NTSR2 SPDYE4 RNF115 MAS1 CDK1MAP1LC3B KLK6 INSL6 MC1R AURKA GPR18 RPS4Y1 NO_MATCH_53 LAP3 GSTM5TOLLIP SDC1 NO_MATCH_93 NSFL1C USP30 NR2E3 FKBP6 TRIM4 ARMC8 MAPK12DYNLRB2 SNX18 PATE1 TTC25 GALNT6 NEURL3 NKAP EMILIN2 TESK1 ASB16 WDFY3EEF2KMT ANKRD12 SNIP1 MRPS34 DUSP15 OR56B4 SEC14L3 GPR157 TTLL1 PRAMESHBG FAS C12orf43 IL20RA COX4I2 POLDIP3 DIABLO DCLK3 NAA16 DGUOK NUP35EPB41L4A-AS1 XLOC_I2_009833 HTR1B NOL9 C10orf111 C16orf58 PPM1K GRAP2TEAD2 BUD31 CA1 TPST2 ZAP70 TARBP2 IFNLR1 HAGHL GNAL NASP ATAT1 PDS5BSPDYE1 SCGB3A1 HTR1F SRMS C6orf201 DPY19L3 SPIB SESN3 RAP1GDS1 OAS1CREB5 SLC6A2 VKORC1L1 WRAP73 C1orf198 DOK4 P2RX1 CEBPE NUDT9P1 F11 TRIB3MAPT HIST1H4E SLC5A10 INHBA TMPRSS6 FPR3 PIP4K2C DPPA3 LINC00588 ECI2PRR13 WISP2 CYP27C1 PLA2G16 CAPNS1 ABCG8 TIMMDC1 NO_MATCH_228 COLEC10ANXA8L1 PSMD10 TCEANC2 SECISBP2 GPR171 CSNK2A1 IMP4 CCDC130 LIN28B CCR5FBXO2 TGM2 DOK3 DAOA MC1R SPIN3 PRPF38A KDSR WDR48 ZC3H14 KIFC3 TPM4FLT1 TSSK1B ADH1A DTYMK RUSC1 AZGP1 THAP1 CIAPIN1 C8orf48 HOXA6 SERINC2EPHA6 GATA3 TMEM59 HHIPL1 ACTB Usp32 RNF141 PEA15 SSX2 GPR82NO_MATCH_254 DHDDS MSL1 GALK1 DCAF8 PLOD1 LRRTM2 CFL1 PTH1R NPR3C20orf141 DIP2A PRKAG3 FCER1G GBP4 PAFAH1B2 AKT2 HIGD2B THBS3 KITLGIL20RA NUDT22 TTLL6 RWDD2B WRAP53 DAPK3 SIGLEC12 F2RL1 FFAR2 PNPLA1TTC41P CCDC82 BTN2A1 MFSD5 RSPH3 PMP22 FUT3 AVPR2 CIDEC HSD17B13 OTUB1ESAM TOR3A SMG8 ROR1 TMED7 GBX2 DYRK3 TAAR2 TGIF1 ZDHHC4 NSUN4 CFHR2ENDOD1 PPP1R2 CHMP7 CNP DNAJC5B UBE2J2 ABLIM2 KIAA1456 ALG2 XPA ABHD4GNMT UNC5CL C11orf49 ACTR1A KRT19 LPCAT2 OR14C36 ZAP70 FAM212A SDC2FUT10 CDK5 KCTD6 KRTAP5-9 SAR1A SH3GL1 TRAF3IP3 AQP12B FAM181A OR4D10C1QBP RAC3 COX20 GRB14 POLR2E RPL11 HS1BP3 COG4 MRM2 ACD LIMK2 TXLNAATP13A1 CDC20 FOXN3 SLC39A4 TCL1A NO_MATCH_83 TCAP ECH1 NXT2 C14orf28OR2B11 PTGIS KCTD14 ZCCHC11 SNRPN MLLT6 CYB5A ST3GAL4 IFT22 COPE PLA2G2DPLD6 NR1H4 SELENOM DAP FSD1L RAB33A ATP6V1C1 TADA3 SDHAF2 EEFSEC CLDN3LCN12 Sgsm1 AURKC HAGH COL2A1 ATP6V0D2 SLC29A1 MMP3 SUB1 DPF1 STRAPSLC1A5 CCL3L1 NO_MATCH_248 NO_MATCH_118 LOC102724652 PCDHGC3 PRKCI PIGTJADE2 C14orf119 GPR135 SLC35G2 TADA1 LGALS12 CRYBA1 EXOSC1 BDNF MED4SLAMF8 JTB SLC25A18 STK25 NO_MATCH_273 ST6GALNAC5 MAGED2 GABRE GIPRFLOT2 RBM18 GNAI3 ISY1 RNF166 MIA3 CD3D SRM PIFO CNN2 ORMDL3 TMOD4 ELMO3BVES CCDC78 SLAIN1 EYA3 FBXL15 CSNK1A1 THRA IFI27L2 MAPK13 RPS6KL1 HSDL2DTYMK TRIM62 CDK16 RBM42 MORF4L1 FOXS1 LHCGR RBKS MAPK1 ZBED8 PMS1 NR4A2HMCES PSMB1 PNKP IFNW1 HIST2H2AB MAT1A NXPH4 DUSP10 TYRO3 ITPK1 ACVR1GGH CNR1 FBXL17 PIP5KL1 CCDC146 FAM189A1 NOV MUM1 TCP10L TMIGD3 APBB1IPADRA1A KHDC1 STK38L FBXO4 DLX5 TGIF2LY TDO2 DRD5 APOL1 KIRREL RIPK3C19orf45 CCDC107 REEP2 FNDC3B FAM126B MPP1 WDR5B C5orf22 CD14 AP1S2 ATF3EML4 TSC22D4 PRDX3 TUBB TCERG1L OTX1 LINC01620 MAPK3 NUF2 BLVRA TACO1ADK PSMB4 LMAN2 TMEM167B GRK7 SPHK1 RPL10A ZADH2 TMPRSS4 TRIP13 S100A14ZNF641 CCDC183 ATP5E ACOT8 MEMO1 SUOX LIN28A VN1R4 RAB15 SDHAF1 HLA-CZFC3H1 SAYSD1 PLEKHO2 RNF32 IQUB ARNTL2 PAQR8 CYGB DFNB59 CD82 THTPAASB11 HIST1H2AJ LOC100130950 DUSP4 ALDOC CDK1 CBLN2 SQRDL LYPD4 DNPEPRAB11FIP1 VWA2 CAPN3 RPS2 FGF10 TRIM27 RDH11 XLOC_I2_005151 PCBD1 SGSHECHDC1 MAGOH CHST4 SEC61B AIG1 VDR VPS36 GDE1 NR1D2 RNF133 TSC22D3 MC4RGHSR Egln2 WARS GM2A TPRG1L LMO2 ANKRD49 GABPB1 CDK5RAP1 DBNLLOC102724813 C1orf43 PARP12 GPR22 B4GALT3 KIRREL3-AS3 GPR139 TMEM116NMNAT1 OSER1 ZC3HC1 CCDC43 APIP CADMl HTR3C CHRNA7 HAUS1 EPHA6 STPG3TWF2 ETNK1 NO_MATCH_151 SLC25A29 FDPS C1orf115 GPR12 APLNR HOXB7 EID3SSFA2 NO_MATCH_116 PTPN18 NO_MATCH_168 STOML2 DCAF10 GATA4 TBC1D21 ADAD2GATAD1 PNKP KLC3 IL6R PIGZ PPM1L S100A1 SORT1 POLM PMVK NPRL2 PAK1IP1OTOP1 SAMSN1 OPRM1 FAM135B PRELID2 GPR12 Hkdc1 PPP1R1A TACR1 PLCXD2SULT1A3 GTF2H3 TK1 CEP104 GTF2H5 SPATA4 KLHL18 HFE2 RPL38 ABAT TRIM55CHST8 MAPK8 TMEM143 CDK4 RAN ANKRD53 FLJ33534 GCSH DSTN ADORA2A LPCAT1UCP1 TMX4 SSX1 PRKCE SLC17A3 HMGB4 SLC25A6 SERPINB8 HSF5 GSTM1 TTC23LZSCAN1 MSX1 CYTL1 POLDIP2 CYSLTR2 ZNF581 SH3GLB1 SLC41A3 ZBTB47 CALYMICB GPR32 TTC28 GPR61 SCRN2 AUNIP CAMK1 DNAJC27 PRKRA BTN2A1 NPB ABLIM3SRRD AK5 NAA30 CLEC10A UFC1 LOC102724151 HEXDC OR8D2 CYB5B MRAP VNN1CTSG GNGT1 OR1Q1 ELF2 KLK14 PPP2CA ST8SIA3 TMEM11 TNFRSF1B PIP4K2A FN3KSERHL2 TSPAN11 XCR1 RPS6KB1 NR2E1 HM13 AHNAK GSDMD CD5L PAH NO_MATCH_77SLC35C1 CKM TCTA LRRC52 TEF ZMYM6 CHMP2B SEC13 SFN Arnt NTN5 BTG3 NAA10NO_MATCH_90 PORCN TXNDC12 CHI3L1 AAAS RSPH3 DOCK8 INHBE BCL7A PRSS45CDC42EP2 ALPL LYPD3 AGMAT ACSF2 EIF2B2 LOC652276 ADAM22 DUSP3 TPD52L3RASD1 SLC25A14 XRCC3 GET4 CASP14 CD38 FFAR3 CATSPER2P1 HNMT GOLGA2P11MOGAT2 FABP6 MTHFD2 TRIM49C NCF1 OPRD1 ADSL ZFAND3 GPR83 MMP23B SETD3KLRC2 PEX3 RCC1 HNF4G VNN1 C19orf53 ACTL8 TBC1D20 MPPE1 XLOC_007668BTN2A2 CEPT1 MOB3B TAC1 SHMT2 LRRC56 EMC3 NPY RPL31 LOC401296 TIMD4 AENSGCD MYADM HTR1F TAT NPY1R GPR3 LOC107984086 F10 SSX3 GMFB ARL4C KRT18TMEM106B GPR108 SPANXN3 SDHC MRGPRX3 SPOCK1 LOC338797 FAR2 LYPLA1 KCNE1NUBP2 STX1B AMIGO3 OCM BRINP1 GALM CAMK1D IL26 MRPL48 ARHGEF38 CSNK1DTMBIM1 ZNF707 UBAC2 LANCL1 UBL7 ZCCHC24 OTX2 RSL24D1 IKBKG GXYLT2ANGPTL4 GOLGA7B FOXR2 NO_MATCH_188 CA8 LOC107984058 BTN3A1 LRIF1SLC22A12 FCER2 SOD1 CDC25C DOCK5 FBXL19-AS1 RPL13 RBKS SDHA PI15 SLC35G1VEPH1 ATP5I NEK6 PDXK MOK SFXN3 TWNK C2orf50 GPX1 RPP38 RAB34 TNNC2RPUSD3 TCTN2 LMNTD1 HS6ST1 RBM4 RPSA H3F3B ALPPL2 C12orf74 CSHL1 BORCS6NXT2 SPSB2 HSPA4 HBEGF GLP1R STX17 RER1 Sec31a CDK5R1 HACD4 CSNK1A1 PROCSKP1 TPM3 DUOXA1 CBX8 OPRK1 IL17A SFT2D1 CREB3 ZNF343 CSNK1E DYRK4MAB21L1 CCNJL ERCC1 CAMK2N2 BCAT1 NO_MATCH_49 EIF6 MPPED2 CBR3 OLFM4IFNA1 SH2D2A TMED2 U2AF2 P3H3 OR1M1 XLOC_I2_000048 FBXL2 NDUFA10C20orf197 TFEB CRNN CPNE5 LGALS14 RAB14 AKR1B1 GPR162 PCMT1 FAM78A STUB1PMEPA1 ZNF428 MRM3 SLC6A5 OLR1 NUDT14 PIP5K1A MAPK10 ZNF2 EFNB1 RAD9BPGRMC2 STYK1 STAC MAFK SGK494 AHSP YIPF2 TNFSF10 ARIH1 SMPDL3A THOC7SRGN OR2D3 TESK2 MYCBP IFNB1 PXYLP1 DYNC1LI2 PPM1K FUT2 RPS13 STX1AFBXO17 RGS18 FNDC5 BOD1L2 RPLP0 SFTPA2 MS4A4A NCK1 OR51E1 TXN TCF4TPD52L2 EEF1G SCAMP3 C1QTNF4 MB FAM109A GMPR2 EMC9 ZFAND3 GPR63HIST1H2BO PKMYT1 PCGF5 CXCR1 RASD2 LAMP5 FN3KRP XRCC3 MANSC1 ANLNC6orf106 ZNRD1 XLOC_I2_009493 MBTPS2 NO_MATCH_282 GPR3 FFAR4 CRYBA4ANTXR2 TEKT4P2 TPRA1 LAMTOR4 MTFR1 RSRC1 DRD2 PTTG1 ESR2 DCK GIP TMPRSS5SPRYD4 KCNS3 SELENBP1 DYRK1B RPA2 ELOVL3 ASTN2 IRAK1 DAD1 MSI2 RPSAAPOC3 PNKD EIF2S3 COQ8A GSTM4 ALDH3B1 PGK1 AVPR1B NO_MATCH_41 GLO1 TPK1IP6K3 KLK3 OTULIN C12orf65 PTRH1 GABARAPL2 TIGIT RPUSD4 KIR2DL3 PSTKNO_MATCH_205 UQCC3 FGF1 TACR3 IL34 SRSF2 NO_MATCH_170 C12orf66 TACR3PI16 MYH7 UBXN1 OR56A1 POC1A RGN GPSM3 ZNF320 FECH SPANXA1 PTX3 PRRG3SSX2 KRTAP4-2 DDAH2 TAS2R40 LYZL4 KLHDC10 ELOF1 PIGV AGFG2 ALX3 CCR6ODF4 MYL1 OR2L13 DCAF4L1 ZBTB26 ECHDC2 TRAPPC2L NDUFS3 CYP19A1 AREG KIF9DPYD C14orf80 POLE FAM219B PMS1 HTR3C HLA-DRB1 IL1RN PMPCB TMEM234 HDDC3TP73-AS1 PAF1 ENSA CYP2B6 RAP1A Spire1 LAMTOR2 SPIC CERS2 CSH1 ETNK1KDELR2 SLC38A7 TAAR3 CYP46A1 PRSS37 MCUR1 KLHL3 HSFY2 RBM17 TEX33 TUBG2HNRNPC CARNS1 TYRO3 NHLRC1 C1orf21 CLIC2 WDR53 KHK PRSS58 SGK2 AURKAZNF576 HTR5A ARFGAP1 UBOX5 PRKX NAA20 MED10 CAMLG TIGD6 BMF PYCR1ATP6V1D FGFBP1 CLIC4 DLX3 POU6F1 SYT14 CNR1 CT45A3 C3orf49 CDX4 NABP2OPN1MW PLEKHS1 OR13A1 CDC42BPG CSN2 DCAF15 PRL KLK1 MARK4 ANKRD23 RLN1ZNF397 CD68 CD4 ARPC1B RIDA HEMK1 ELF5 HCAR1 CCDC50 MAP3K11 ABHD10ZNF585A GPR83 TADA2B LPAR2 SAAL1 NO_MATCH_177 OR51E1 SULT1C2 HOXB-AS3DIAPH1 PIGO KYAT1 CSN1S1 NDUFA4L2 ATL2 PDIA5 TOM1L1 TUBGCP4 KLRK1 TICAM1C16orf87 CAMK1 CD80 NO_MATCH_106 PCED1A PDIK1L POP7 MAP3K12 CLEC17A GHSRTMEM186 ZNF497 SLC22A23 INSR C19orf57 IQCC FPR1 ADH7 POLR2A PNP AURKAUGGT2 ECSIT MRPS24 ZBTB32 APIP ZNF785 GPR84 NR0B1 NR2E1 SSMEM1 PPIF NME7UPK1A IMPAD1 GNPTG USP28 BPNT1 POLR1D C11orf63 PKLR IP6K3 LOC105379861MEIS2 KRT79 LRRC46 TEX26 GPRC5A ID3 TMEM184C KIAA0513 PTGDR PLD4 SLC8A3IFT43 B3GNT3 MAPK15 UQCRB MRPL18 ANKRD55 NTMT1 FUNDC2 ENAH COASY PDLIM1MBP TMEM87A LRRC39 EEF1AKMT1 RPS8 SYP CAMP SERPINF1 CCR10 NKG7 NAALADL2ZMIZ2 PRKACA MAPK15 ATP1B4 MECP2 EXOSC8 RELA PTPN18 RBM11 SECISBP2 RPL14SLC38A5 DEF8 PRAF2 MTHFSD PTGER2 CDO1 SNRPB2 CSNK1A1L MYLK2 PPM1M TMCC2R3HDM2 LRRN2 CDX1 AKAP9 C2orf54 DNAJB12 SPCS3 CNN3 PSMB4 TIMP4 FTL BTNL9ASPH YAE1D1 TRIM43 ANKRD22 NPPA ARHGAP6 CPSF4 TGIF2LX SLBP SFXN1 TEKT5OR51E1 TIRAP GP6 ZNF169 TRIB3 CD52 ARPC4-TTLL3 SLC25A15 IL20RB CHIC2MAB21L3 PGK1 ACKR1 CHMP4A CYP2E1 SLC22A7 PIK3IP1 SLC13A2 STARD7 GPR108USF1 GAGE5 ACOT13 ROPN1L ZNF254 DAPP1 EMP3 SUCNR1 NMUR1 TTC1 P2RY2 F3LOC541473 RNF2 PLIN3 SLFN5 SPATA32 CATSPERD GSAP XLOC_I2_009464 TMEM185BMVK GPX4 NO_MATCH_14 GPR84 DCTN4 GIMAP5 RPL3 ZFC3H1 PHPT1 GLOD4 NMUR1ADTRP FAM151B ADAT3 TMED9 Mok MC1R CXorf40B FUT7 DPM1 ACAT2 HTATIP2CRIP2 RHEB DYRK3 FDFT1 GATA2 ZNRD1 AMZ2 MAD2L1BP WT1 ADAMTS4 DUSP12B3GALT4 RPLP0 CDRT4 IRX6 STRADB STK17A KLRF1 ZNF830 TYR FLAD1 IKZF5 VRK2GPR6 TPGS2 TSSK6 VIPR1 NFYB MTMR14 DNAL4 CCR6 PRCC DUSP14 LINC00526RAB34 TEAD1 SLX1B FBXW4 ZNF626 HMOX2 CHRFAM7A IL20RB HOMER1 LNP1LINC00482 SAP18 GALNT10 HNRNPA2B1 AIF1L ESD C19orf38 PPP1R14A HYAL3HAND2 GPR37L1 FBXO27 PNCK PSME2 OPN1MW TGFBR2 USP47 MOB3C CHIT1 TMEM176BHNF4A ARHGAP32 APCDD1L NMRK2 RXFP4 VTN GPR84 PQLC2L C2orf27B CLEC12APBDC1 GPR160 MRFAP1L1 MRPS18A RABL2A WNT10B GCLM RIMS3 AQP11 AIDA BBS10PAQR5 CDNF RARB CALM2 ZC4H2 SGCA KRTAP10-7 KRT73 OR8A1 IRGC TIGAR HVCN1ZFP57 TPD52L1 C8orf46 HLA-DQB1 WDR25 TMEM140 SYNE3 NCOA7 KLHDC7B CHMP4AAIM2 SLC46A2 GPR151 CBR1 CYB5D2 VASH2 EP400 CLASRP MOCS1 PRKACG STAU2CEP170P1 ZNF169 MTCH1 AKR1C4 NO_MATCH_153 LMO1 RASGEF1C HS3ST5CYP1B1-AS1 ATP6V1G3 GRB7 IL15 BAX RPL14 S1PR5 MTRF1L ADORA2A PRH2 POLLFSD1 TRIB1 LINC00260 MKRN3 BET1 GRPR ASF1B SH3BGRL FADD A4GALT NUDT21SPINT2 TSSK2 SEC14L3 RAB1B ZNF684 TIMM17B RAB2B RPS17 SPATA45 KLHL14KLK3 SNX12 FUCA2 OR1A1 NO_MATCH_104 NETO2 OBP2A EIF3F HRH1 MTFR2XLOC_I2_011954 HBE1 ZNF562 AKR1A1 ATP5L2 ACAT2 NO_MATCH_30 GPR25 TMCO6GALE CYP1A2 CDK10 PM20D2 TRUB1 PCNP AK4 NKX2-5 DKK2 RNF25 ADORA2B FGF14SF3B6 PTGFR IRF3 DNAJC5 FFAR4 C11orf42 PGLS SMIM12 FAM192A METTL1 HHIPL2CTSL UBQLN2 DDX51 NO_MATCH_270 MRPS2 AKR7A2 STARD3NL CCDC106 PDE4DIPINVS NUDT4 SELENOP SBDS DGCR8 AK4 RNF43 DRD3 NUDT1 KCNK17 CRHBP SPATA24TFF3 RAB7B LMCD1 RBM15B YIPF7 DOK2 GPAA1 MCCD1 CD48 NEIL1 LINC01465 MAPTDENR BAG2 PSMG3 GIN1 MXI1 EPYC BCAS2 PGK2 AKR1C3 KNSTRN UHMK1 TMEM177MRPS23 HNRNPA0 TESK2 SLC25A5 ODF3L1 FANCD2OS NO_MATCH_146 CCR9 RGRSLC25A39 VPS29 MGAT5B SPNS3 MORF4L2 GPR1 LIN37 SCGB1D2 PPM1N MVB12ANO_MATCH_260 NEU4 NKX2-3 ZFAND6 POLR2L RET SPC25 TSPAN15 ASCL4 SETD4MC5R SCAMP3 ZNF277 MAPT SLC5A12 Dmc1 THEM6 GPR152 EXOC3L2 HLA-DRB4 ARF1FPR1 BTNL8 KIR2DL2 COX5A HAPLN3 PCBD2 SPSB1 C1orf210 GPR182 BCL7C LARP1BPCGF2 PGLYRP3 LINC00982 CDIPT-AS1 WNK1 GPR137B PVALB F8 FGFR4 PACRGFBXO6 UROD DLL4 TNFSF4 NO_MATCH_186 RHOF KRTAP9-2 THEM5 KDELR2 RTKN2NO_MATCH_197 DHRS12 SPANXB1 GNRHR TXNDC8 NTRK1 ZNF580 MRPL20 TEKT4BPIFB1 OR6K6 STK11 CAPS2 NO_MATCH_24 OSTC TMEM183A IDH3B FAM170A PVRIGPBLD NO_MATCH_194 PARP11 UTS2R LPXN PYHIN1 MS4A3 DPEP1 BLOC1S5 HTR1D TFGPSMB7 FTL PAX8 ST6GAL2 CELA3A TTC9C CLEC18A DSCR4 CSTA C1orf94 GTF2H2C_2C11orf52 CDIP1 TMEM100 C6orf136 OR13A1 HIST1H2BJ COMTD1 HTR3E CCDC103NCOR1P1 LHX9 MAFF ZNF692 GPR39 CCDC43 SPATA2L MGST1 PPIG HLF UBXN2A CRCPWDR45 APOBEC4 GPRC5C XRCC2 TRIM61 TIMP2 PRPS2 OPRK1 SYT11 SURF4 DYRK4PNMA6A MYL12B PTH FAM102B BLOC1S2 AK4 CDKN2C MRGPRG-AS1 TIPIN NO_MATCH_1ZCCHC13 TEAD3 NCOA1 HIF1AN C1D GSG1 RAB6B C5orf24 SURF2 RCSD1 MMABCEACAM3 FAM136A IL17A LINC00471 ITGB3 RAB3IL1 TUBA1B SPAG9 GNGT2 NAXDPI4K2A XLOC_I2_011911 FAM53B TSPAN7 RAP2B ARMCX1 HOXD4 NUPL2 S100A9GPR171 CCDC71 NEGR1 NIPSNAP3A CXCL5 IZUMO4 EDEM2 LINC01559 RPRM PYCARDZFP36 RELA SLC12A7 RALB DEFA5 ZSCAN32 GLYCTK MYL5 CYR61 RNASET2 CIR1ARSJ SPRY2 TRIB1 HOXB1 KTI12 CABP4 DESI2 IDNK PELI1 LRAT FABP7 ZMAT5MAP3K12 Trim72 TMEM150A DPY19L2 NT5E FAM19A5 ZNF542P BCKDHA OR51G2 ACMSDAES XLOC_I2_015213 SNX21 MRPL47 MRGPRF LOXL4 TMEM18 YBX2 PAQR5 WISP2AP5S1 DALRD3 NO_MATCH_13 PHB ARHGAP5-AS1 TREML2 GNB1L WASHC3 MUSTN1 C1QCPHF19 CYP17A1 UQCR11 GPR152 ATF5 FAM122B PEF1 CCNJL CHMP1A PTMS SLC19A3LRRC61 UBE2B S1PR4 RDH13 RAB17 RASSF7 NO_MATCH_169 MPZL1 CTSZ GALK1TMUB2 GALNT6 TSSK3 DMRT1 SMPDL3B GPR176 MYBPHL SCRN2 DRICH1 VMO1 HOPXNRAS SLC1A7 EGFEM1P COPS3 AKT2 ZNF521 Mok MZT2A GPER1 MAPK10 SCP2D1PTPN23 SLC10A1 TCTEX1D1 ZNF593 DIO3 STEAP1B HPSE SLC35C2 TMEM55B BSCL2CRYBB3 WFDC2 PNCK TIAL1 EPPIN ETS2 NO_MATCH_206 SKA2 HIST1H3F CHKA GDAP1TGM1 PDLIM5 PANK2 GPANK1 GPIHBP1 SF3B4 HOXD10 PAFAH1B3 TARP R3HCC1LPLAC9 ZBTB25 SPP1 C22orf31 Timm8b UBXN11 NUS1 INPP5K ASB9 MT2A SELENOVAGTRAP TMEM41B TTC32 AGR3 MAB21L2 FCRL2 NAPRT HTR3A ALDOB REG4 SCAND1CD2 HLA-DRA BTN2A2 TSFM TBPL2 NIT2 TBC1D3H AURKC POGZ CRB3 CTRB1 APOMARPC5 CLEC7A ZNRF4 PDCD5 PKMYT1 IL36A GABARAP FAM219A NDP HAPLN2 AURKCTAAR2 DEFB129 KCNMB4 PFDN1 OGFOD3 CSH1 HSD3B7 TTC21A ASTN2 CSNK1A1 KLF10RDH5 RPE65 RHBDD2 TIMM10B RNF41 SH3BP5 SERPINE1 ERLIN2 RAB40AL PTP4A2TMEM51 CHST10 RCE1 XLOC_I2_004853 CSRNP1 CYB561 GABRR1 IFNG DHH NYAP2ELK3 GRN TTC31 PMF1 HOGA1 SNX11 CAPN3 XLOC_I2_003293 DNALI1 TtLL5 SNCGKIR2DS1 PDCD6 DNAJC12 RNASE1 EGFL7 EAF1 TAPBPL DUSP21 RPS14 SLC22A23WISP1 VSTM4 CCDC114 CCR2 CCDC74A C21orf62-AS1 SLC25A37 MLST8 SDC3 GPR68LGALS9C CEACAM7 P2RY2 STYK1 VGLL2 ANKRD33 KRCC1 BAIAP2-AS1 ABHD15 ART3NEK10 DPH7 CLEC5A CLN6 DTYMK EIF4EBP1 OLR1 ECE2 SFT2D2 PRNP C12orf45ZG16 EMG1 LYRM2 HLA-DQA1 PSMB2 FPR2 GPNMB PIP PPIAL4C FKBP11 JTB OLIG3SSH3 ZSCAN16 C2CD2 ZNF550 NO_MATCH_247 NSMCE3 ATP5L THRSP IL5RANO_MATCH_120 F2RL3 BOD1L2 IL32 PSMD8 ICAM2 GPR148 RPL13A HYAL2 LEFTY1EBP HSPB6 CHRD MCUB SOX15 NMUR2 DRD3 GSTO1 SERPINA5 DIDO1 PKMYT1 GPX3GSKIP FN3K KCNJ15 MMS19 OR13J1 GPBAR1 TMEM51-AS1 GTF2I SRPRB ADGRG3TUSC3 ROM1 ANG AP1S3 TSPAN33 GUCY1A3 ADAM17 RNF144B GTDC1 PAGR1 BDKRB1NO_MATCH_157 CRP CLK4 HS2ST1 EIF3K KLHDC8A IGFL2 RNPS1 RABL2B CCDC74BRFFL TIMM50 FNDC4 VGLL4 FIBIN CPLX4 LPAR6 SGK3 C12orf10 NO_MATCH_114GEMIN8 TTC4 PSG1 RAB26 SIN3A CORO1C NOSIP MED20 UBTD2 DHRS3 GPX1 IHHGJB6 MAX SERP1 CHI3L2 RPL15 XLOC_I2_010511 TIAF1 KCNIP2 TCTEX1D2 TMEM86BMED20 NPTN ZNF385B OR2AE1 COBLL1 SEMA4G IQCF1 TMEM51 BTNL3 PCBD1SND1-IT1 CXCR2 SLC47A1 ZC2HC1B XLOC_010930 EID2B PHF19 BGN ALG13 MRPS16TNFSF11 ALG2 SPN TMEM89 RGS4 IDI1 KDELR3 MAPK3 HTR1D RGS5 SLAMF9 RETDCAF10 GPR18 SEMA6C PMVK XLOC_I2_015196 HCFC1 ZNHIT3 SERINC4 CCM2FAM103A1 GRN STC1 TXNDC9 C1orf94 ACKR2 PCSK9 MTRF1L SURF1 DCAF12L1 PIPOXTMIGD1 PRDX6 LRRC71 NDFIP1 DUSP4 RTN4RL1 CCL13 TAS2R3 NR0B2 POGLUT1CDK5R1 MT1E TMEM44 PRPS1L1 RABIF PDIK1L UBL5 IMP3 PLPP6 CCDC51 CLEC3ASPAG7 TSSK3 GH1 NO_MATCH_31 NO_MATCH_269 GNRH1 SPATA3 SLC1A7 TPD52L3 LATNO_MATCH_267 RASAL3 SLC22A18 S100A9 DUT CD300E MMD SPSB4 FASLG DCKLINC00314 OR2T4 Scrn2 PRPS1 PTK6 STAC3 C17orf78 APEX1 DHRS1 GRIN2B RFKGP6 FCRL1 GDE1 KRTAP1-1 ARSA SLAMF1 LOC107984065 MAP4K3 GCSAM PSCADPY19L2 TM4SF4 LRRC37A FAM177A1 RNASE11 M6PR HYPK ARF5 ZCCHC16 FAM46AP2RY6 NFKBID XLOC_005712 LDHAL6A TCTE3 NME1 CCL16 SCNM1 BDH2 NRN1L NAIF1C15orf59 VIPR1 YOD1 NPFFR1 APOD DYDC2 ASB4 MIR1-1HG TRIB1 42802 DCDTMEM261 TXNL4A TMEM107 RPL23 AKT2 LSM7 OR6V1 SMAD9 SMIM19 GPR162 EFNA1PIANP ZNRF2P2 DKFZP434K028 NDUFB2 SYT3 CLDN14 IP6K2 ACKR1 EIF4EBP3KCTD21 P2RY4 FAM122C VSIR Tmem208 TM2D3 HBQ1 GP6 SUN1 B3GALT5 ATG10AURKA RAMP3 BORCS7 CTAG1A KIF26B HRASLS5 KRTAP19-4 HSD17B6 WDR6 NR4A1FOXP1 FXYD3 TBX20 FCGR3A PISD SERPINA3 NPBWR1 C3orf38 VMAC NFE2 INSIG1HSD17B7 URM1 ITM2B GAGE1 CSTL1 HEATR1 PTGER2 GPRC5D GNB5 HCN3 FCGR3BTDGF1 RPL37 DSCR9 SLA2 HN1L C1orf123 PTGER4 SLC51A RUFY4 QRFPR C8G RPL28TWIST2 NXNL2 SRI FAM63B HIST1H1T RAD9A ZNF524 FAM213B ISG20 SLC25A30 HBBXLOC_I2_006425 TAF9B TMEM37 POFUT1 HTR3A RWDD3 IL3 SDR39U1 COMT STK32APrrc2b PRKAG1 TBP NO_MATCH_165 Clk3 SNAP23 PDLIM7 PHTF1 S100A9 GINS2STAG3L4 U2AF1L4 CRADD LINC00508 CLDN12 WDFY2 SCIMP APEX1 B3GALT5-AS1P2RY14 MIS12 RNF138 SFXN4 UBD SERP2 RNF212 ORAI2 RPS16 KLK5 KRAS CCDC33GPR157 GADD45GIP1 ZFHX2 MYL6B SGF29 TAS2R13 GEMIN6 POP4 LOC650293 SPATS1NRBF2 LHFPL4 IL6R NUPR1 FAM8A1 MIF RPS3 UQCC2 AURKA FFAR1 PRUNE1 NINJ1ELP6 CLSTN3 EMB HYI ODF3L2 CRKL EDF1 AANAT CCDC102B SMAGP TRHR PRR22MLC1 COA3 SERBP1 PHKG2 SMN2 LGALS1 PYY PDCD1 MRPL43 NO_MATCH_266 DHRSXPARP16 AHSG SLC25A17 APTX SNX27 PFN3 NO_MATCH_64 ZNF672 RBPMS MBD3L1 RGRKYNU OR10H2 NME1-NME2 TPM3 MVD SFR1 TAS2R42 ZDHHC12 LSM12 NAAA TSACCSAT1 PKD1L2 MAP1LC3A CD300LF MAPKAPK3 RPS2 SH2D1A QPCT CMKLR1 SSBP2WNT9A CLIP1 AK2 PDCD1 C8orf74 NO_MATCH_110 SEM1 GNG4 TYRO3P ARL2BP RXFP4OXSM TNFSF11 MLLT11 ZNF324 DEFB134 THAP8 RAC2 MTCH1 EBAG9 NPFF MPG DCNTMEM107 GALNT12 XLOC_I2_009500 AICDA HN1 PI3 OR6B1 CISD2 PLPPR5 RPP25LNaa10 SPANXD UBA6 GPR152 S100A3 TMEM174 YIPF1 IL7 RIPPLY2 TPRX1 HIST1H3HRpl36a FOXS1 PTH2 C1orf158 OPN3 HYAL1 CDPF1 FCGR1A FOXR1 TEX264 RNF24SFTPB NO_MATCH_129 GGCT ATP6V1G3 UQCRQ C7orf34 CNPY3 GH2 DEDD2 MTAP CROTZNF718 KLHL35 IGFLR1 FAM167B OR6N1 INIP TREM1 FAM198B S100A2 PNPLA1NO_MATCH_122 PRR5 C11orf57 OSMR SCN2B MRPL30 SCRG1 PRKRIP1 WFDC5 DUSP3GFRA1 OR2A2 ADCYAP1 ZNF544 C16orf54 IPMK RHOQ UFM1 SMDT1 RAB8B TMUB1RARA SIK3 FBXO32 TXLNGY SLC25A22 BLVRB OPN5 LAG3 C1QB MAPK3 NO_MATCH_99WFDC9 FTCD XLOC_012726 TAS2R60 GPR142 NRSN2 HMP19 SEC11C C17orf64 ENY2STK35 NT5C SERTAD3 ZSCAN31 CHRDL1 NRP2 NAT8L LRRFIP1 SOCS2XLOC_I2_007111 TMEM55B BIRC7 NTRK2 RGS8 SECTM1 NRG1 TPO KLF6 AK4 NDUFA1CHRNA1 ST8SIA1 PTGDR EHBP1 ARPC4 REEP1 GPR34 IFT20 MRPS18C ANAPC10PNPLA5 SPACA9 COX5B HIST1H4I MCHR1 TMEM35A RAB40B C1orf74 ANKRD42 ZPLD1CCL8 PQLC1 FAM174A HSPB11 XLOC_I2_010863 MRPL57 TAF12 KRTAP13-1 UNC119CH25H PAGE2 GINM1 KCNK4 CYB561D1 A4GNT DLX6 TMEM171 TMEM31 PLPP6 CTLA4OAZ1 ANG SUB1 NO_MATCH_78 C8orf58 RCAN3 PLA1A CHCHD1 C15orf53 KRTAP15-1G6PC3 XLOC_I2_009492 GNRHR XCL2 CLDN4 SMCO4 DUSP7 TTR SMIM21 TMEM239LRP1 TUBA1B CENPW AP5B1 LURAP1L TEX36 PRKAG1 UBE2J2 PDE6D PLAC8L1 DMRTC2ACOXL-AS1 C2orf76 NO_MATCH_171 ATP5H DERL2 KIRREL3-AS3 FAM189B KRTAP13-2FXYD7 FKBP1A DBNDD2 MRGPRX3 PTPN22 SCGB2A2 CCDC24 NPFFR1 C2orf88 IL9TIMM22 EPO CIB1 FADS2 ATP5D XLOC_013551 VSIG2 OR2A4 STPG3 CELA2A ERBB3GPR148 DNPEP ZFPL1 TEX261 THAP7 BHLHE23 LCN6 NDUFS6 CDCA5 CCL5LOC100653061 PARM1 KLK4 TPST2 FOXA3 FCGR3B CELA3A NDUFAF5 RPS10HIST1H2BN ATP6V0C INO80C DUSP13 PERM1 FDX1L CNOT7 CELA3A RAB7A LY6DPEX11A SEC22C OSR2 ATP23 SOSTDC1 EMC6 NO_MATCH_136 APOC2 PAGE5 KIF19VAX2 HIST1H2BK GOLT1A IL36G PHF5A GNG11 HOXB5 GSTA4 SLC10A3 OR6M1RUSC1-AS1 LOC151760 RAMP2 C1orf105 CELA1 CCDC126 OBSL1 XAGE2 BIN3-IT1RNASE7 GP9 EIF4E KLHDC9 FAM46B C12orf49 MRPS11 LOC400710 MRO SYNGR1ST20-AS1 DPF1 DUSP9 ATP11B TESMIN TMEM14B NKAIN4 LINC01657 FXYD3LINC01667 MARCKSL1 NDRG1 HSPBAP1 GPR20 GPR146 UBE2V2 GZMB NINJ1 MUM1CLDN6 ISOC2 PTGDS XLOC_I2_006955 MTMR11 HTR3D LOC403312 MAIP1 CYSLTR1NFKBIB SUMO1 OPCML CRYGC SFTPA2 CA13 TACR1 ATP5J CXXC4 42796 CCDC69NPBWR2 LHX6 SPATA25 TREX1 NXPH3 RPL27A PLA2G4D MRAP2 OVCA2 FAHD2BLINC00346 KCNE5 C6orf226 NTM ZDHHC16 TTC9B NO_MATCH_159 OSTM1 XBP1 IL23AFAM74A1 NINJ2 LOC107987001 TACR2 AXIN2 HSBP1 HIST1H3A CDK3 FXYD6 PILRAAPLNR DEFB127 C8orf33 APBB2 KLK10 CDC42EP1 ABHD17A RXFP4 C6orf120CCDC189 ACY3 BATF3 KCTD7 COQ4 NO_MATCH_109 HOXA5 SSTR2 Trim41 NTF3FAM180A AGPAT2 VAMP2 OR2T27 LDB3 KLRC1 FDCSP HOXD9 LOC146880 PCBD1 RD3TMEM17 LRRC28 TDGF1 MAGEA1 ANAPC13 GHSR GPRC5C TEX264 MORC2-AS1 CXCL6RNF152 NO_MATCH_44 STX12 NO_MATCH_167 IFNL1 HMGN2 GPR180 MEX3D TBXA2RNO_MATCH_139 AQP5 PLA2G15 UBE2D1 POLR2E TM6SF1 C11orf68 RAMP3 DCXR SFTPCNDUFAF4 SLC35E1 FRMPD4 Ccdc28a ROR2 CSF3 C19orf48 SLURP1 SPINK7 TGIF2NECAP1 GZMH CKLF FAM218A PTGES2-AS1 LOC105376844 ZNF300P1 CRYGA VAMP4FAIM2 LACRT LIMD2 CTBS KRTCAP3 NGF GTPBP8 YKT6 NO_MATCH_142 SLC10A3SDHAF3 MT4 OR6B2 CER1 PEX11B LINC01587 TMEM51 SWSAP1 RPS27L TSSC4 PTPN22PNPLA4 LEFTY2 EIF1B XLOC_013281 SCGB2A1 AMTN SLC31A2 SPATA46 MPDU1 LYPD1FABP2 FGFBP1 KIF25-AS1 PLP2 PSMF1 C9orf24 NFATC2IP GALR2 IFNA2 ATG12LOC107987205 IFITM3 DLK2 KLK2 C1orf64 HOGA1 CSDC2 ACYP2 C10orf55 IFNA5DIRC1 CDA GNG7 FAM124B REG3A KRTCAP2 IMPA2 TMEM136 TRIM35 CCL26 KRTAP3-1GULP1 HIST1H2AJ LINC00479 XLOC_013643 ATOX1

TABLE3 RNAseq of OCI-Ly1-R vs OCI-Ly1-S SYT11 PARM1 MAP1A GPM6A ROBO2RGS16 AOX1 CDK6 IGKV1-5 RP11-539I5.1 BEST3 TRIM46 PLCL2 GLUL YES1 P4HA2CD48 NOL4 IGLC6 GATM PYHIN1 TRO C7orf72 DZANK1 TLR7 CRYBG3 RP11-284N8.3SGCB PLEKHO1 KCNA3 MIAT BACE2 FCRL1 KIFAP3 DOCK10 KIF5C NPL C14orf132FSD1 SLAMF1 NRP2 SOX4 SLC12A8 CD69 MORC4 SPIRE1 CNKSR2 VANGL2 ST20-AS1KIAA0040 HMHB1 QSOX1 TNFRSF21 GALNT2 NAP1L3 LY9 CEACAM1 RP11-544M22.13AMICA1 LRP6 BMPR1A CDYL2 CYP2U1 CBFA2T3 KCNMB2 SIGLEC10 PRAMENP OPTNATP8A1 STX16-NPEPL1 BEX2 ADAM22 PDE4DIP SNED1 ANKRD50 LINC00649 ZNRF2NFATC4 ADAM19 TRAM2 ARHGEF6 CTSH FAM198B CD1D NPNT PAPSS1 TWSG1 PELI1IGF1R ADARB1 HEY2 RAPGEF5 RP11-196G18.23 C4orf36 CENPL TP73 ARHGAP30RAB39B AFAP1-AS1 LAMC1 MED12L CTD-2561B21.5 MEF2D MSANTD3-TMEFF1 PBXIP1PCDHB15 PRCC S100A10 MEGF11 UBE2E2 NBPF9 CDC42EP3 MAGEA3 TRAF3IP3 PRAF2GLDC CTD-2517M22.14 DNM3 WHAMMP2 LRRC8C ZBTB38 COL18A1 DNAJC12 RCSD1ATP8B2 CHST15 LINC01138 SMCO4 MSTO2P SLC25A24 CD80 NRG3 CBLN3 PEA15CCDC74A MEX3A SESTD1 TSTD1 TRBC2 WDR35 NPIPB9 LDOC1L ASH1L-AS1 MCL1NBPF11 RP1-152L7.5 TMEM2 ABCD2 DTD1 RIT1 RP11-876N24.1 NUDT17 AGMATSNX27 ATRNL1 RP11-796E2.4 DUSP12 ADPRH NFATC2 RPS27 ACP6 CHD1L TRPS1SUCO RNF2 ARNTL2 WDR17 TMEM256-PLSCR3 PHLPP1 ASAP3 MEST DYRK3 ITGA3SLC9A9 ADAMTS6 RP11-16K12.1 NBPF19 PCDHGC3 CAND2 CADPS NETO2 FAM163BPYURF NBPF15 CDC42SE1 ACBD6 AC006978.6 DLEU1-AS1 TET2 UBQLN4 VPS72 HACE1SLC18B1 SF3B4 MPP1 ETV3 MAGEE1 YY1AP1 RASGRP1 IQGAP3 MGST3 RFX5 RNASELFZD3 SEC14L2 HIST2H4B KLHL20 PRDM5 UMODL1 IFI16 RP11-495P10.1 ARHGEF2PIP5K1A MRPS21 GORAB MPC2 CICP16 PPOX ADIRF-AS1 TNFRSF13B CEACAM21 SIAEPMF1 FCRL5 SLAMF6 TADA1 ILF2 ENSA METTL18 PROX1 LINC00869 CTIF TSC22D1RP11-514P8.8 NBPF12 GPR89B PDZD2 SCYL3 VAMP4 CCR7 SSH3 SETDB1 NUF2 HAX1FCRL2 QKI B4GALNT1 SGCE AXIN2 VWCE RGL1 LBH CKS1B UBE2Q1 NBPF14 SLC25A44PIGC MYEF2 VPS45 PYGO2 PRUNE GPATCH4 PITPNM2 COLCA1 S100A4 BTNL9 BTLAARNT AC074289.1 AZI2 DTX3 ZC4H2 TMEFF1 CARD16 COPA NME7 PMF1-BGLAPCTA-293F17.1 HDGF IGSF8 SEMA4A POGK RP5-940J5.9 APLF MRPL9 WI2-1896O14.1PELI2 USF1 XPR1 TTC3P1 CYP2R1 CCT3 LRP4 RP11-44F21.5 ZSCAN9 RGS8 BBS9RAB3IP PSMD4 RPRD2 HEG1 PRKCB PFDN2 LINC00921 FAM102B PTPN12 RELL1BCL11A PRELP MTURN UBASH3B ANXA2 POLR3C AC006129.2 AFAP1 SLC26A1 IRS1C1orf112 ADAR PI4KB PODXL2 C1orf220 ANP32E LRRN3 STAMBPL1 CREBBP PIK3CAPLEKHG2 FAM167A FMO5 FIG4 PLK2 APBB2 SPA17 ARHGAP21 PSMB4 TPM3 MARCH3ISG20L2 RHOU CH17-472G23.2 CDHR3 PHYH DCAF8 NCSTN GON4L PKP4 MYO5A HELBABI2 ZNF845 PMVK ADA SELL TIPRL PEX11B GFOD1 CGN HIST2H2BE PCGF5 ZNF831SHC1 LINC00441 RUSC1 TBC1D3G APCDD1 FAM175A DEDD UFC1 ATP6V1G2 USP46RMDN2 PRDX6 SCAPER FOSL2 ZBTB37 PARP15 PDGFD RP11-404F10.2 MSTO1 PSD3CCSER2 GGT7 ZNF641 RP11-196G18.22 PPP1R3F NPAS2 RGS3 TSEN15 CLK2RP11-294J22.6 GATAD2B RASSF6 SLC39A1 PRPF3 CARD11 CFAP73 RP11-458D21.5CH17-472G23.4 TICAM2 AHDC1 RASGEF1B EDN1 SGMS1-AS1 XXbac- SNAPIN SHOX2NFKB2 BPG252P9.9 BIN1 XXbac- RP11-543P15.1 INTS3 ATOH7 EVI5L BPG154L12.4DUSP10 TUBA1A CHST6 SLK CYP1A1 RP11-337C18.8 FER ITPRIP ELL2 KCNMB4HDAC4 LMO7 PDE4B CAMK4 UBAP2L FLAD1 RAG1 RASGRP3 GPR155 BCL9 CA8 BLZF1PRKAB2 GBAP1 PIAS3 CERS2 MAST4 JTB SCAF1 ITK NIT1 PRRC2C FCRLA CCDC167CREBL2 VPS54 RNF144B RP11-296O14.3 DCAF6 HIST1H1C CCNB3 LINC00461 SSR2DAP3 RAB9B SLC19A2 FCGR2B PCDHGA12 APH1A NBPF20 RP11-175B9.3 INPP5F SMG5MPZL1 GCSAM CHTOP RNF115 APOA1BP SH3BP5 BCAT1 MAP2K6 RP11-134O21.1 UAP1IGLC3 ABCB4 PAPSS2 CTTNBP2NL CTD-2368P22.1 DDX54 CRTC2 ATP1B1 GOLGA8NRBM8A LPP TNFSF8 AFF1 PEX19 CASP1 CTC-490E21.11 XXbac- POGZ STARD3NLSCNM1 SEMA3F BPG283O16.9 ZBTB7B RP5-1028K7.2 RP11-87G24.2 CTD-2036P10.5TIAM1 MIR3180-1 RFNG PCDH9 RALGPS2 ATG9B KRTCAP2 PRDM15 ID3 RP11-830F9.7AC009299.3 C1QTNF6 RRNAD1 TOR1AIP2 RFWD2 CRISPLD2 ILDR2 TARS2 MEX3BSYNE1 NPHP1 ARHGAP17 IGLV3-27 KCNJ1 SETD1A GPR89A ALDH9A1 SYBU GBP2MRPS14 PEG10 SNTB1 CD84 GAS5 GABPB2 IL23A CMAHP LRIG1 LYSMD1 PLGRP5-1068E13.7 SPOCK2 NOTCH2NL AGO4 CACYBP GARNL3 FCRL3 ABHD6 AC240274.1MPP2 METTL13 LAMTOR2 CTC-436K13.5 EFNA5 TAGAP NBPF1 ATP8B1 RP11-452N17.1USP21 GNG2 KIAA1211 AC091132.1 C3orf52 PCDHB14 CEP350 RP11-1070N10.3CSGALNACT2 LINC00624 MTM1 CEP70 SFXN5 EFHC1 TMEM79 GIMAP2 SNAI1 ARPC5DENND4B CP LINC00863 IGHG1 PTPN4 ZNF71 STX6 RP3-428L16.2 RP3-455J7.4SPHK2 TMEM14A GPR137C CACYBPP2 CTSS ARHGAP5 RGS5 UCK2 ABL2 MAP7D3 TUBB2ASTK38L KCTD17 HCST MRPL24 RP11-132N15.3 C11orf49 MICA NYNRIN DPYSL2LRP5L RP11-156K23.3 OXTR YPEL1 MIF-AS1 FBXO16 IPO5P1 DUSP6 RBMS1ARHGEF38 CUZD1 LYPD1 C1orf43 IRF4 DDAH2 NANOS1 ZNF653 RECK PXYLP1 ARL3PFN2 PTRHD1 ASH1L ZNF80 TMCO1 CH17-189H20.1 DLGAP1-AS2 RP11-77P6.2 GSPT2RP11-363E7.4 NPIPA5 RIC8B TCAF2 RP11-843B15.4 PPP2R3B PPP2R3B SRGAP2BAIF1 MYL12B MLLT11 STOX1 MYO3B LRRC1 TSC22D1-AS1 SRGN UGT8 PRRT3 PLEKHA3SMG7 KCNH2 GPD2 KYNU ARL4C NBPF3 FMNL1 EDEM3 KIAA0907 SYDE2 CYTH4 ROBO1FAM157A WDPCP CACNA1C LRRC16A PCNXL2 SDHC C3orf62 AP3S1 EGR1 CCDC141TRMT1L MYOM2 RP11-564D11.3 RP11-428K3.1 MOB2 LRRC70 TOLLIP PRCAT47 SYNE3CCDC122 RPGR TMCC1 FRMD3 IGLC2 ICA1L CORO2B F11R ANKRD36BP2 SWT1 SLAIN1C9orf72 CMTM8 BDNF-AS ATF6 EFNA4 PCNX MAP2 ZDBF2 FCRLB FDPS PPFIBP2WDR86-AS1 DYRK4 SDCBP INPP4A CRNDE PHF21B GOLPH3L SETBP1 RGS5 ZNF521PDCD11 SLC36A4 EFNA3 TCEAL4 SCAMP3 CACFD1 CECR1 RP11-67L2.2 HIST2H4AFAM189B ABCA6 AGK ITPR2 HABP4 ZBTB8A LCMT1-AS1 CTD-2162K18.4 FILIP1LAFAP1L2 TMTC2 ZNF493 SEMA6A-AS1 LLGL1 KLHL25 SCIMP ZNF511 SFR1 IVNS1ABPRP11-160O5.1 OSER1-AS1 SLC14A2 AC005795.1 RELB ABHD12B CEP126 TPST1C2orf48 ACVR2B RP11-734K23.9 GBA AP001062.7 PKIA ADAMTS7P4 PLA2G4B TRIM8MREG ATG4C FAM72D RP11-422P24.12 WASF1 NBPF26 LRRC37A6P POLR3GL TRPM1ABCA5 CH17-353B19.1 AC245100.1 GALNT18 STX11 BBS5 RNF144A SNURF PEPDENPEP TCP11L1 ARMCX6 ACSF3 TNFSF4 ZNF90 DDR2 AIM2 ACER2 CAPSL FGGY SOAT1RP11-471N19.1 ZDHHC2 MAP3K1 TSPYL4 NCF2 GNA12 IKZF5 MAN2A1 RP1-178F15.5EXOG CNIH3 PNMA1 MFI2-AS1 RP5-1098D14.1 HIST1H3G CSPG4P12 RPS6KC1 MINPP1RP11-326G21.1 DARS2 BTBD9 PDCD4 TGFB3 SYNGAP1 AC099342.1 GLYATL1 TOM1L2S100A6 RIMS3 PANXI RP11-887P2.3 CCDC17 ZC3H12B BLNK CDKN2D PHGDH NCK2LGALSL PYGL ST3GAL5 ASB8 BORCS7 RP11-876N24.2 GADD45A BCORP1RP11-290F5.1 KIZ RP11-337C18.10 TNFAIP8L2 NUGGC NBPF10 SLC50A1 TOR3ATUFT1 MTSS1 TAF9B USMG5 RPS6KA2 NOD1 ADGRB2 BDH2 FCGBP RP11-437B10.1ANKH HS6ST1 KLF5 ANKRD34A ITGB8 DNAJA4 FANCC RGS10 DUXAP8 CCDC28BRP11-336K24.12 CBX1 ANKRD20A2 LPP-AS2 CAMK2B STAT5B JARID2 SAP30 USP27XCALD1 H3F3AP4 IL17RA CLGN DRP2 ZNF780B TBCK RP11-105N14.1 SMIM24 S1PR3FAM72C PACS2 USP2 DUS3L SCRN1 MCF2L2 ANXA11 CCL3L3 ATXN3 ICKATP6V0E2-AS1 ACTN1 DGAT2 TCEAL8 JAZF1 TNFRSF17 RP11-73K9.2 LHX4 ACKR3SPRED3 EML5 SRGAP2D AHR RPLP2 FBXO15 ZNF687 SSBP2 MSRA CFAP157 DHX9SFT2D2 SLC25A28 SASH3 RP11-53B2.6 LL22NC03-N64E9.1 HBEGF NPHP3-ACAD11UHMK1 RP11-159H10.3 GKAP1 FAIM LPIN2 SIX4 PNOC BTD OPN3 FZD5 DUSP8RP11-126K1.6 MAD1L1 KDM5B GLMP LINC00278 FAM219A ADAM32 PPP5D1 TCAF2P1PIANP KLF9 ANKS1B KIF20A FZR1 TNRC6C JAG2 ERMN RAB25 PJA1 RP11-774O3.3RP11-522I20.3 CDK5R1 AC021106.1 GNAZ ZDHHC8 SETP9 LRRC47 TLE1 JAK1 MTMR2NEDD4 DHRSX DHRSX ENC1 HK1 SLC30A1 PCGF1 CTD-3222D19.9 PLEK ZDHHC14IL10RA BCL2L2 NT5C2 FOXD3-AS1 BOLA1 SNHG8 DPF1 ARPP21 TXNIP ZSCAN12P1HIST1H2BJ MGLL B9D2 RP11-56M3.1 DOPEY2 EYA2 SMARCD3 LIX1L GHITM CMTM7SSR4P1 CBX6 SLC10A5 CNR1 SUPT3H RP11-352M15.2 BTRC PKD1P5 IRAK1BP1 BRSK1KATNAL2 CD160 SCN1B YPEL2 WDFY2 HDAC5 RPS13P2 LINC01102 RGPD6 CORO1AMICAL1 RP11-363E6.4 CTC-436K13.1 TCAP RCOR2 STARD10 IGKV4-1 RNASEH2CGTF2IRD1 TNNC1 ARMCX2 RAB23 AC006946.16 ARHGAP44 TAF8 SNX24 RAVER2RP11-365P13.5 KLHL32 SLC9B2 MED12 VARS APBB1 RPS6KA4 GLTSCR1 LEF1 NPIPA8IFI27L2 GSAP RGL4 TMSB15B KCNN3 PITPNM1 PTEN FSD1L CALCOCO2 PCDHGA10TMPRSS13 RCN2 ZNF583 SBNO2 GAK GGH AP001372.2 POLD1 RP11-1415C14.3ZNF862 RGS13 IMPA2 PIM2 AC093724.2 ZC3HAV1L RP3-382I10.7 DCAF15CTA-390C10.10 GSTO2 SLC25A29 AOC2 NUDT4P1 NUDT4P2 PIGCP1 IFIT5 ZBED1ZBED1 RP11-542M13.3 CD247 UCHL1 RP1-111C20.4 AC007040.11 KIF16BRP4-647J21.1 VAV3 NAP1L5 PRR29 RP11-278C7.3 PIP5K1B TERT PAQR6DLGAP1-AS1 C3orf18 SEMA4C RP11-875O11.1 GVINP1 RARA RP11-620J15.3 FLNARP11-119F19.5 GPC1 KIF13B OAZ3 THUMPD3-AS1 SRP54-AS1 VILL PPP4R1L TAPBPLSH2D3C GALNT1 CDK18 ZSCAN16-AS1 RP11-29H23.5 AC019118.3 ASPHD2 ULK1SLAIN2 CD1C PTBP2 GRAMD1A CARD10 HCN2 PPM1H RAB37 CSRNP2 FAM120C CBX4RP11-10K16.1 ESR2 RP11-196G18.24 LINC00667 CERCAM RP11-422P24.11CTD-2270L9.4 FNBP1L ZNF230 NDNL2 MYH3 SENP3-EIF4A1 SYNGR3 TIGIT PLTPAC129492.6 RP11-93K22.13 BRF1 HNRNPA1P7 H1FX-AS1 AC006128.2 ARID5B SORT1CFAP20 GAB3 TESK2 VPS9D1 CLCN5 BANP POU4F1 AL365181.2 C10orf76 RHBDF2USP46-AS1 GABBR1 TAGLN2 RP11-121L10.2 HIST1H4H HIST1H3H RP11-216L13.19RP11-706D8.3 PDE11A PPFIA3 PLGLB1 ST3GAL4 NDUFS2 STARD5 DUSP5 ABCB1EP300 PRSS16 MED25 SMARCC2 NATD1 RBM12 ASMT ASMT EVL FZD2 TOR1AIP1CCDC61 RP11-91K8.4 CAMKMT LINC01226 ZNF516 TAB2 DMWD ZBED3 RGS2 THAP8PPP1R13B RP11-641D5.1 LPAR4 RP11-398C13.6 CBX2 KCNMB3 CTC-378H22.1PPP1R14BP3 ENTPD1 LIPT2 TOMM40L RP11-611O2.3 MAP3K14 KEAP1 RP11-673C5.1ISL2 ERAP2 AKR1B1 WAPL TMEM265 DGKD RNF146 SNX22 UBQLN4P1 C1QTNF3FAM110A DLG4 RP11-21K12.2 SPRED1 CYP4F29P KLHL7 ZNF571 A2ML1 METTL25PIP4K2A IL16 ZC3H4 GPR19 ARHGAP23 TTTY15 ZNF443 RP11-571M6.7 IER3ZMYND11 PRC1-AS1 FERP1 GH1 CELF2 RUFY2 RP11-403I13.8 KLC2 CCDC191 FOXP1RP11-36C20.1 FAM24B CHD3 TEX41 SH2D2A MAP1S RP11-706O15.5 GOLIM4 MXRA8DPM3 TSPAN18 ACBD7 CBX7 HIST1H2AC TMEM254 TMEM170B EHMT1 ZNF850RP11-35G9.5 BZRAP1-AS1 DEPDC1B GUSBP9 RP11-404F10.6 C4orf32 CDC42BPBGABARAPL1 RP11-481J2.2 SPATA7 TOX2 EFNB2 MAGED1 USP11 POU2F2ATP6V1B1-AS1 KLRC2 AICDA ZNF438 HIVEP2 MMD RP11-197N18.7 ACRC RP6-74O6.2CYB5R2 LENG9 LINC01559 MTCL1 GLUD1 C1orf198 PGBD1 PLPP1 GLTSCR2 ZEB2NUDT6 B4GALT3 CTD-2336O2.1 CH17-373J23.1 RP11-771K4.3 FCGRT SCN4AHIST1H2BD PSRC1 CTD-3203P2.1 IKZF3 FAM153B AC004623.3 ARL4DRP11-277B15.3 ALDH16A1 CALHM2 TIGD3 AC116366.5 HIST1H2BL FAM195B MARCH9PHC1P1 FNDC5 RP11-464F9.1 TPM4 RBM11 HIST1H2BC ITGB2 LINC01481 PHC1MAPKBP1 AC010642.1 ST6GALNAC6 JADE3 HORMAD1 USP12 TGFBR2 C22orf34 TYK2IGF2BP2 ANO6 DKFZP434I0714 RP3-486I3.7 HSF2 GALC CTNNA1 MYO1G FAM156BTTC24 FAM89A HIST2H2BF KIAA0355 SSX2IP LTBP1 FOXD2 CTD-2270P14.5 PAK1GPATCH2L RP11-1280N14.3 HECTD2 XPNPEP1 PIK3R3 RP11-76I23.7 ZNF385ADNAH11 RP11-328P23.4 KIAA1614 KCNC3 XXbac- ATRN NCEH1 BPG299F13.17DHFRP1 ZNF765 ARL10 FAM20B RP11-367G6.3 RFPL4AP1 TMEM67 SIT1CTD-2521M24.6 FAM45A KRT18P34 RABGAP1L IDS MYLK3 RP11-1079K10.3 TAF5FAM212B ANG PDK3 CA5B RP11-1070N10.6 ZNF559 LIPE C11orf24 TP53BP2 H1FXAKIRIN2 TOP1MT AB019441.29 KBTBD11 AC093642.5 SRRM2-AS1 AKT3 CAPN10-AS1FAM215B GPR161 RNF19A RAD51B MANF PKD1 ABAT OVOS2 RAB11FIP2 PKD1L1ZBTB42 CTC-490E21.14 ACTN4 KCNIP4 CCDC112 RP11-133K1.7 SBF2RP11-20I23.13 RP11-10N23.2 RP11-553L6.2 RP11-111F5.8 BAG3 FAM174B LIMK1RPL23AP21 SORL1 TNRC6B EHD1 RP11-967K21.1 KIF11 OGG1 HPSE HLA-DQA1RP11-53B2.3 KCNA2 EGR2 RP11-500C11.3 SNRPEP4 C16orf74 KLHL6 RAP2C GPR55CGRRF1 C11orf84 GS1-358P8.4 PDE6D DOCK4 RP11-175K6.2 TMEM216 ZNF439MAP3K4 TCF7 RP11-67C2.2 ZSWIM5 FAM168A R3HCC1L CCT8P1 TCF3 ACACB STK39EGLN1 LDB1 CA14 DIRC2 L3MBTL3 LLNLR-245B6.1 WDR27 FKBP7 RASGRF1 EXOSC1PAFAH1B3 RP11-312J18.5 MIR34AHG XXYLT1 ANKRD13B RAP1GDS1 CTD-3222D19.12PRKCA KCNK12 SLC1A2 ZBTB39 ELL2P1 TUBGCP2 UBE2C RP4-570O12.3 EHBP1L1NELL2 FAM161A HEBP2 KCTD12 LINC01297 RP11-175K6.1 RP1-178F15.4 CEP170P1S100A1 IRF6 RAB11B-AS1 FTO B3GLCT CTD-2287O16.5 RP11-343C2.12 ZNF35VPS41 IGLC7 HGS CUX1 GOLGA2P7 RP11-797H7.1 PTPRU OGFR CBX8 AC241585.2RAD51 ALDH18A1 SAMD4A ZNF708 FST RP5-940J5.6 NUTM2A-AS1 AKAP3 PDCD2LEPOR KIAA0319L AC072062.1 DDX10P2 ADGRL1 ARHGAP19 ZNF816 APITD1-CORTRP1-193H18.2 ANKRD6 TRIB1 MARCKSL1 MX2 LOXL2 RP11-517A5.5 ANTXRLP1CDC14A PFN1P8 RAB3B PIPSL EGLN2 RP11-467H10.1 RP11-468E2.5 RNF25 IQCDMYB SIX5 CTC-453G23.8 MT2A AKAP5 AP003068.23 RP11-110I1.14 ETV6 MSANTD3CD2BP2 MURC LGALS1 RAG2 ANKRD24 RAP2A ATL1 RP11-696N14.1 MTX1 SLC35D2ZNF93 SYT17 C4orf3 OVOL2 NR5A2 ZCCHC18 BIRC3 ZFP30 RP11-761N21.2 WBP5EVC2 RALGPS1 UMPS MRO CTBP1 YPEL5 KMT2B FAM221A CTD-2562G15.3 RNF24APOC3 PPP2R2D KATNB1 OTUD7B RP11-286N22.6 OVAAL IGLV10-67 RP11-753C18.12GNA11 RN7SK SPINK2 NAGK RP11-34F20.7 RP11-573D15.9 GLRX ARHGAP25 TIAM2CEP55 TRIM17 BCL6 AC144449.1 AP001432.14 MZF1-AS1 METTL12 IKZF1 FABP5P7ZNF177 CD244 KCTD1 CTB-31O20.4 SAMD9L RP1-267L14.6 NLK LYRM4 APOC4-APOC2TRIM3 HMGN3 MARCH2 CAMSAP1 SPATA5 THEM4 CTNNB1 RP3-467N11.1 MYL12A ASB2PCDHGA1 PPP1R26 RP11-506M13.3 CABLES2 MAP3K14-AS1 CAPS U47924.6 RAB31FAM57A KIAA1024 BCL2L1 TTC31 RP11-757F18.5 FGD2 RP11-196G11.1 PHC3 UXS1KMO CTD-2545G14.6 EAF1-AS1 CIB2 GTPBP1 NUDT4 ARID1B FTX CCNYL1 CASP9ALG14 CH17-174L20.1 SNORA59B MAPRE2 RP11-713N11.5 CASK MARS TSPAN11RAB11B C2CD3 CLDN4 RP11-466A19.8 RUSC1-AS1 ZNF136 KCNK9 CCDC186 BBIP1B4GALNT3 MSI2 RRN3P3 FAM222B SPOCD1 RP11-308D16.2 PSIP1 ZFYVE27 SGK1ERCC1 TUBB3 LINC00854 KCNJ16 ST3GAL3 CREB3L4 TAPT1 CTD-2583A14.10LINC01311 RP11-87G24.6 FZD8 TLDC1 NOLC1 ZYX RP11-328C8.4 ALS2CR12 ST13P3C18orf32 AVPR2 DNMBP TBC1D23 KHNYN PTPN9 RGS20 RP5-894A10.6 NUDT22RP11-131L12.3 EIF1B-AS1 C2orf42 RNF41 SETP14 TFDP2 CD5 CTB-50L17.8 NOMO3C1orf226 SPATA13 C17orf53 EXTL3 RAB11FIP3 CTD-2319I12.10 SLC39A10HIST2H2BD FLOT1 RP11-566K11.4 SON CAPN10 GPLD1 ATP2C1 LINC01054RP1-223E5.4 BAIAP2L1 RP11-624M8.1 CNPY4 RRP12 RP11-466F5.8 TMEM129 LEPRMICE MTA3 TM9SF3 CXorf21 FUT8 RP1-153G14.4 U1 ZFP82 CEND1 ZXDB SLAAF011889.5 PGM2L1 PLEKHM1 TPM1 RP11-378A12.1 BMI1 RABL6 RPLP0P6 AGO3C6orf1 RP11-26J3.4 NRL Z84812.4 DDA1 LY86-AS1 TTC3 C14orf79RP11-1319K7.1 MIF AC006129.3 AC009303.2 KIF15 CYB561D1 UBE2FP1 CRHR1-IT1KDM1B KCNAB2 SPIN1 HOXC4 FMOD SSBP3 RP11-532F6.3 AGAP7P GBF1 KIAA0430DDIT3 HIST1H2AI MPZ C5orf66 TUBB6 TPH1 LIN7B AC006548.28 RP11-848P1.9HSD17B7 TSC22D2 ARHGAP12 FAM53A POU2AF1 SEPT7P9 PHF2 LINC01480 FCGR2CIL20RB ACSBG1 RP11-172H24.4 HOXA6 ELL3 CTC-343N3.1 WDR1 ZNF730 DMRT1RPL22L1 ACE RP11-347I19.8 LGI4 KPNA5 SMAGP RP5-890O3.9 SLC35E4 CALCBAC098614.2 FKBP1C FAM35A ZNF75D FAM104B CTXN1 RP11-111M22.2 RP11-135F9.3MCF2L RP11-367J7.3 POLRMTP1 SEC23A VLDLR VAT1 KLHL22 SEPHS1CTD-2020K17.1 ZNF22 EDC4 SHMT2 WDFY1 EPB41L2 RPL12P28 CTSK DUSP28 GPANK1KDM5D AC020571.3 CKS1BP3 ZNF473 KIAA0513 MICU3 TRIM32 SLC26A10RP11-452F19.3 EGFL8 AIP GMDS HELQ IGLV5-45 RP11-158I13.2 GPR63 BPGMRP11-862L9.3 BTG3 KATNAL1 TMEM206 LINC01296 TELO2 ZNF137P ERC1CTD-2373J6.2 RP11-17P16.1 DENND5A ENOX2 VAMP1 GOLGA2 REXO2 GAS5-AS1IQCJ-SCHIP1 MIDN GMPSP1 AC090957.2 FOXC1 SLC2A8 RP11-542C16.2 MT1XNAALADL2 ADAM10 ADAMTSL4 CLDN12 MIR600HG RP11-50C13.1 TIGD2 PRKD3MSANTD2 C16orf62 RP11-461A8.4 PDE5A SRP9P1 HOMER3 GGT1 HES6 WFDC21PLINC01024 RP11-158K1.3 RAB27A SCML2 SLC25A53 RP11-475C16.1 PSMF1 NFYBTOMM7 RP11-495P10.10 KLHL17 RBM8B ZNF772 ASPH RP11-864N7.2 VIL1 IL2RAATG2A MIS12 PAK4 GGACT KIFC1 SLC7A7 RP11-474I16.8 AIM1 PDE4D RCAN1 POTEGHIST2H3D PPP2R1A PABPC1P7 HIST1H2BK CTB-55O6.12 RALGAPA2 FBXW8 RPS6KA5POLR1A RP11-147L13.13 ACADSB CBX3P9 CAMSAP2 ATP7A CTD-2267D19.3RP11-162G10.1 REM2 SUV420H2 HMGB2 ZNF561-AS1 CTC-523E23.11 LA16c-306E5.2EIF2AK3 PDIA3P1 STAT2 RP11-393I2.4 RP11-465L10.10 AP2A2 FYN DENND5BRC3H1 RP11-1023L17.1 CTD-2291D10.4 DHPS ASPRV1 AF001548.5 RASAL1AC073869.20 RP11-29H23.6 LAMB4 RP11-399J13.2 RP11-307C12.12 RGS12RP11-155G14.6 RP11-203L2.3 ASS1P12 MROH6 XYLT1 CCNY HIST1H2AG PLEKHG4BEEFSEC LTBP4 IKBKE CTC-444N24.6 ACOT7 GS1-114I9.1 HMGN2P5 RP11-631N16.4RP11-422P24.10 RP11-881M11.4 SIPA1L1 Sep-07 RP11-927P21.5 AC079610.2FBXL14 KIAA1551 YEATS2-AS1 LINC00936 TRAM2-AS1 LINC00630 ANGPT2 MLLT4RP11-229E13.4 PCGF6 MATR3 SF1 FAM214B AC129778.2 KIAA1107 KIF20B IL12RB1IER5 ARL8A GTF2H4 VGLL4 RPGRIP1L CACNA2D1 EHD3 C5orf30 ANKRD16 RGPD2CTC-351M12.1 EFNB1 LINC00672 FBXO27 ITFG1 C11orf42 MRFAP1L1 HMGN4 THG1LPPIP5K1 ATXN7L1 TMX4 MGRN1 ABHD4 FLT3LG ELOVL7 PRX TP53INP1 ZEB2-AS1RP11-2E11.9 AC020743.2 TNS3 RP11-46H11.12 RP11-650L12.2LL22NC03-N14H11.1 KRT8P12 UQCRFS1P1 RP11-359J14.2 CLPTM1L RP11-104F15.9ALLC ASAP1 NAP1L1 PBX3 FBXO46 RP11-705O1.8 DDX26B RHEBL1 CH507-513H4.4CH507-513H4.6 CH507-513H4.3 IGLJ3 MVP GPT2 GOLGA2P10 FAM50A RP1-292B18.1RP11-88E10.4 CASC3 SNRPGP2 KBTBD2 RP11-264E20.1 AZIN1 RP11-226L15.5FBXW4 AL162151.3 RP4-669P10.19 RP11-638I2.6 WDR60 HCG18 RP11-552M11.4RP11-142C4.6 UBE2S RGPD3 PCDHGB1 CDC42EP2 ZNF28 TVP23A RP11-35G9.3 ADAM9GDI1 CTD-2116N17.1 MTHFSD CUEDC2 GABPB1 RP11-1035H13.3 RP5-882C2.2PDCD4-AS1 SLC2A13 SOS1-IT1 EXOC2 Sep-01 SOX2 FAM43A AC016700.5RP11-6N17.4 AKAP7 ZNF844 EMC3-AS1 AGTPBP1 EIF4BP6 TRIM28 SMC3 ADORA2BB3GALT4 TPM3P9 IL22RA1 BACH2 HNRNPA0 ZNF629 PRKD2 RP11-321N4.5 STMN1LINC00163 PIGM KLHL11 PRKCE CUTC THBS3 AP3B1 PHF19 KLHL7-AS1 DHX16TRIM22 KDM1A FAHD2B C9orf64 RP11-968A15.8 RP11-893F2.18 KAZALD1 PKN3ATP6V0E2 EIF5AL1 HIST2H3C HIST2H3A RP11-739L10.1 AC011747.4 CTC1 CD5LZNF711 OTUD7A MYPOP RP11-798M19.6 PRH1-PRR4 RP4-635A23.6 RP11-443B20.1RPL18AP3 PTP4A3 TDRD3 AP2B1 PHLDA1 PIK3AP1 POLR2J4 SLC25A45 ATXN10RP11-1246C19.1 RP11-484K9.4 OTUD1 RCAN2 ATP2A3 RP11-830F9.6LL0XNC01-237H1.2 KIAA1614-AS1 PDZD8 PLXNA1 KCP WRAP73 DYNC2H1 RPSAP15SLC25A27 BUB3 MTERF2 LRWD1 ZC3HC1 FITM1 SAFB DACT3 RP11-180M15.7 TTC5PPP1R16A TPT1P9 TMEM136 CXADR AL513523.2 RN7SKP80 GNAS-AS1 RP11-187C18.3RB1CC1 PFAS RAB26 EFCAB2 RP11-1191J2.5 STEAP1B RP11-330H6.6RP11-441O15.3 RP11-211G3.2 RPP30 RYK MATIA SAP30L-AS1 ABLIM2 PHF8 CDCA2XYLB GLI4 PGAP1 KIAA1324 CHFR BNIP3L SNW1 USP49 CWF19L2 AP000251.3ZNF513 PAPD7 KCNJ2 AGAP3 RP11-111F5.2 TTC8 SMG1P4 SLCO5A1 TXK CADM1AC007389.3 AC007386.2 TOP3BP1 MEX3C RP11-403I13.5 RP1-41C23.2 FAM65BPOLH YPEL3 POLM HCFC2 CARD6 AEBP1 CYSTM1 COPS4 RNASEH2B ZNF407 CLDND1TCEAL1 LEF1-AS1 SLC35E2 CD81 RP11-57H14.4 TMEM117 CORO2A RP4-765C7.2HAUS5 SLC12A2 PIGN CD52 RNF220 C9orf163 INTS4 BEND4 TCTN1 RP3-424M6.4CNNM2 MLF2 IL2RG CRLF1 PCNXL4 PABPC3 KLHL24 BRICD5 THAP3 RP11-530A18.1RBKS SUGCT RP11-343H5.4 RP1-150O5.3 BFSP2-AS1 C7orf60 SIRT1 SAV1 TAF6KMT2E GDPD1 ZNF804A WWP2 MCPH1-AS1 NR1I3 TRPC1 C17orf62 NT5DC2 EMC3PCGF2 TTLL4 RP11-262H14.4 C11orf95 EIF4E3 CDIP1 AC015849.16 RP9 BTAF1AC093673.5 FN3K SNORD17 RP11-65L3.3 INSIG2 SLC44A2 RITA1 NRDE2 DCBLD1RP11-146F11.1 AC138035.3 NUP50-AS1 FCHSD1 TRIM24 RP11-594N15.3 CPNE2ADAM1A RP11-15F12.1 AHCYL2 STXBP5 PDZK1 RXRB FIZ1 HERPUD1 MAGI2 PRR12SLFN5 HCLS1 ETV4 PGAM1 AP001347.6 POLE4 SPAG4 CDKN2AIP RP11-652L8.4PRICKLE3 RP11-182L21.6 TES WSB2 TBL1XR1 MORN3 HOXA7 PWP1 SLC27A2 FAM213ARP1-34B20.21 RP11-380I10.4 MARCH5 ATAD1 CTC-281F24.3 CRB2 FRMD6-AS1CDKN2C TMEM185B RP11-29G8.3 NTAN1 CRMP1 RP3-395M20.9 RP11-295H24.4 MCTP2RP11-253E3.3 RBBP4 CCDC77 SUMO1P3 PI4K2A RP11-20I23.8 LANCL1 BMP2K PAQR3FXYD1 INCENP L3MBTL1 TAB3 TM7SF3 NUDCD3 CCNJ HJURP CHDH CTC-425O23.2ELAC2 RP1-241P17.4 PEMT CCDC168 ITGA2 AC090804.1 AC009542.2 CAPN5 TOM1L2RP11-5O17.1 FCHO1 UBQLN2 P2RX2 HIP1 ZSWIM7 RP11-713M15.2 CD3E PPP1R14DLINC00894 Z83844.1 SNRPGP10 ABCG1 BLOC1S2 SCPEP1 CTD-2287O16.1 PDPK2PZSWIM8 MAPK8 ZNF555 TNKS2 RP11-932O9.7 ZNF157 FLNB CSNK1G2 FANCI TRIM7PDCL3P5 RBM12B-AS1 ARHGEF26 GPR31 DYNC1LI1 SOGA3 AC109486.1 BAIAP3RPS10-NUDT3 EML4 CEP97 MAGEF1 RP5-1136G13.2 RP11-651P23.4 BMPR2LINC01560 ZXDA COMMD3-BMI1 CTC-523E23.5 ZFAND2A WDR86 GRIN2C TMEM65FOXD4L1 CTD-2227E11.1 ITPR1 C5orf42 TUBA3D CH507-396I9.7 RP11-139H15.5RHOH FBN1 MFSD2A PARN HILPDA LCLAT1 AC058791.1 SEMA4G SLC35A4 MAGEH1ANKHD1 ACOX3 C1orf56 GTF2IP4 LINC01144 PDS5B SGOL2 RP11-138C9.1 GABRB2CYLD C7orf26 IGKV3D-7 ST13 ZNF615 RP5-894A10.2 OTULIN ZNF10 SIGIRRHIST2H2AC EFTUD1 RP11-324E6.10 TBC1D27 PPL RP11-566K11.5 RNPC3 GTPBP3CSTF2T NCOA5 RP3-508I15.18 AC016831.7 HARBI1 RTKN2 BCL3 ARNTL IL24 LAX1SAFB2 RP1-47M23.3 RP11-61K9.3 RP5-1159O4.1 C2 RP13-608F4.5 GLCCI1 SNX8SPI1 IGF2BP1 CENPV AC010547.9 FIP1L1 BEND3 RP11-22N19.2 RP11-53O19.1PCGF7P AC021224.1 KIAA1586 RP5-961K14.1 RP11-412D9.4 SH3BGRL3 ZNF384CNPY2 SLC6A9 ZNF878 EHMT2 SMAP1 PRCD CFDP1 MFN2 XKR7 HERC3 FLII DEDD2SH3BP1 ZNF496 RP11-490B18.6 PITX1 CENPW ZNF580 RP11-320L11.2 TLE4RPL23AP97 DGKQ NELFA CTB-119C2.1 ZNF605 FBXO32 RPL15P3 HPS6 VAV3-AS1ZADH2 AOX3P RP11-61F12.1 CASC4 SUGP1 PPP1R10 MAPK8IP3 RAD52 RPLP1P6NCOR1 PPP1R2 HPS1 RAB43P1 OR6L2P ZNF343 FAM120B KCTD7 ASMTL ASMTL SNHG5GCN1 DSE TMSB10 ZNF529-AS1 ACTR1A ZNRD1 KIAA1683 LRRC37A16P DENND2CRP5-1126H10.2 GMEB1 TMEM151B FAM193A THOC3 ADRBK1 ZNF321P CDK2 TFIP11TMEM133 AC008522.1 UTP14A PKMYT1 AC002310.14 SUMO2P17 ACMSD ASB16-AS1LINC00282 AC092835.2 TMCC2 QDPR KIF21B MIR3142HG STXBP4 SAXO2RP11-196G11.3 RP11-83J16.3 TOX LINC01096 CTDSP2 IL17RB ARRDC1-AS1 BAZ2ATTC32 RP13-616I3.1 AC004540.4 ITGB3 SAMD12 EPS8L1 ALDH3B1 FCRL4 AKTIPGPSM3 LINC01206 ATXN7L2 AMBRA1 CTD-2647L4.4 PTCH1 KATNA1 TNFRSF13CDNASE1 DUXAP9 SPTBN4 RP11-326I11.3 CLOCK ZNF623 KAT6A STOML1RP11-649A18.12 ZNF888 RP11-114O18.1 PRKCQ-AS1 INPP5D RP11-44F14.7 ZNF140AK9 CITED2 NCOA2 BX255923.2 ZFP92 SERPINH1 SEC31A CLIP3 ZNF451 TTLL13POPRD1 EMILIN2 RP11-177C12.1 AKNA RP11-33O4.1 RNU12 AC005776.1CTD-2527121.15 RPS6KA3 STX18-AS1 IGKV1D-8 RSAD1 IL10RB-AS1 INTS6-AS1UBE2D1 RP1-28H20.3 GPATCH2 RP1-8B1.4 SLC4A11 ATAT1 RHBDF1 PRKCZ IFI27L1CLPP KHDRBS3 HNRNPA3P12 SCAND2P IGKV3-20 RIPK3 EZR UBE2F-SCLYRP11-351D16.3 RP11-168J18.6 CTB-25B13.12 GOLGA8Q OCRL RP3-399L15.3 CASC5RASGRF2 PLAGL1 CTSF ZNF226 LINC01431 GNRHR2 MAGED4B LAPTM4A PEX10CTC-564N23.2 SLC27A3 ZNF37BP RP11-344P13.6 GK KCNH4 RFX2 AP1S2 BACE1-ASRP1-179N16.6 SAMD15 AKAP8L SNHG14 AC007969.5 CTD-3214H19.6 GNG3 E2F6ASB12 FUOM SKI MOSPD3 GTF3C1 RP11-271K21.12 LINC00324 PAF1 LRRC37A9PC14orf28 SEMA4F RP11-135J2.3 RP11-596C23.2 HCFC1 PJA2 RP11-173A8.2 NBEAMAP2K4 NLRC3 ADM ZCCHC3 DUSP8P5 ERCC4 ZBTB1 COLGALT2 RP5-942I16.1ARFGAP3 YEATS2 DNAJC4 RP11-588H23.3 CASP7 SRI RP11-479O9.4 AC068580.6RFWD3 LINC00237 VPS13B CTC-575D19.1 ARL13B LA16c-3G11.7 FANCG EIF3A MCM4TSC22D3 HUS1 ARHGAP11A RCHY1 TMEM163 TIGD1 LINC01087 KLF12 CCDC24 WIZMTRNR2L8 PSMB8-AS1 RP11-134N1.2 PLEKHM3 HIST2H2AA4 PHOSPHO2 PARP1 VEGFBRP11-746P2.3 RP11-722G7.1 SPDYE2 SNRNP35 C9orf24 RP11-68L18.1 ZNF432TRMT2A IGHV4-59 N4BP2L1 AC005339.2 TIFA DDX50 LRCH3 RP11-430B1.2RP11-211G3.3 RP11-15H20.6 CUL1 ZNF670-ZNF695 TSHZ1 TRANK1 EID2B MCM3APP2RY8 P2RY8 WDR76 COX6A1P2 WDR13 ZBTB18 PLK1 ZNF518B CHUK RP4-568B10.1AC006547.13 ZNF598 KIAA1147 PRPF31 HAPLN3 MAST3 RP11-332H14.2CTD-2342N23.3 ZFAND5 ZRANB1 ZNF271P ERICH6 GZMM RP11-325K4.2RP11-403P17.6 RP11-204L24.2 SNAP47 TSHZ2 KCNK15-AS1 TAS1R3 UROS THRILMBD4 TAS2R12 RP11-91P24.6 RP11-475I24.1 RRM1 ENO1P1 STARD13 HSPA8P3CHIC1 FAM45B TTL PHKG1 RELA RP11-53B2.2 PCDHB12 ZNF749 FUT8-AS1 PLEKHG1ANO8 GAPT HTATSF1 ARHGDIA VSIG10L MAGED2 RP11-863P13.4 ZNF20 AC079630.4NOC3L SIN3B RP11-91G21.1 SIDT1 ZNF133 RP13-103211.7 KIF2A AP002884.2RP4-800J21.3 C1orf50 HNRNPA1L2 RHOC RP11-244O19.1 E2F2 CCL4L2 MKI67RP11-1378G18.1 ZNF416 SLC24A4 CASC2 STYK1 RP11-298I3.5 LDHAP4 RALGAPA1DNMT3A LINC00294 LMLN LINC01011 DGKZ RP11-298J20.4 DMAP1 CAMLG ZNF552RPS28P7 AFG3L2P1 ARL11 HMGN2P4 NPIPA3 RP11-171I2.5 ZNF441 MIR181A1HGBAHD1 FAM27C TTK ZFAND3 RP11-408O19.5 AC002398.13 MED22 ALPK1 IDERN7SL738P RN7SL172P CTD-2530N21.4 POU5F1 HNRNPKP4 POU2F1 COL5A2RP11-110I1.13 RPL23AP2 ABLIM1 ITGA4 CTC-559E9.5 ZBED5 TRMO OSBPL9SIPA1L3 MAPKAPK2 HLTF RP11-643M14.1 DIAPH2 IFT52 CECR2 GPR137 MCMBPKCNE5 CTB-31O20.2 ADD3 HMCES ZBTB5 PTBP1 TRPT1 LRRC8E TMEM235 TROAPMCIDAS RP11-850A17.1 RP11-192H23.7 MAP2K4P1 TFAP4 LINC01089 TNFAIP3 GNB5CMB9-55F22.1 RDH16 EMC2 C12orf57 SCRN3 SCAMP1 AP001619.3 IPO9-AS1 FAUP1ECM1 ZNF331 KCNIP2 SSUH2 TMPOP2 EEF1A1 CORO6 UTY NDUFB8 RUNDC3AAC079250.1 CTC-444N24.13 RP11-359K18.4 KLHL26 CERKL RNF20 DSTN PDK2RP11-567J20.3 LGMNP1 AC004076.5 FUNDC2 TONSL ATP7B RP13-554M15.5RP11-195F19.5 MDFIC PLXND1 KMT2A HNRNPCP2 ANKRD44 DDX24 RP11-75L1.1LINC00426 SNHG6 RP11-428J1.5 ZER1 RABEP1 NR1D2 COL5A1 INO80CRP11-727F15.11 CDC20P1 SEC24D GJB7 TEX29 ZNF624 LIG1 KCNQ5-IT1 EXTL3-AS1FKRP ATP1B2 CTC-205M6.1 CTB-13F3.1 FOXN3 RP11-670E13.6 C11orf30 NPM3 SP9ELF2 GRAP PKIG AC092159.2 LA16c-60H5.7 AP4M1 LRRC8A ACSBG2 ABCD3RP11-690I21.1 LRMP RP11-588G21.1 CTD-2555O16.2 NT5C MED31 TBL1X TRDMT1TBC1D5 ZNF277 IFT27 SEC23IP RP11-353N14.1 HELZ2 RP11-166P13.3 FAAHZNF707 ZRSR1 PRRC2B BMP6P1 PELP1 RP4-798A10.7 JUN RP11-726G1.1 INTS10RP11-540A21.2 CAMK1D OBFC1 RP1-172N19.5 GTF2IRD2 RORA TIA1 CTD-2339L15.3ERLIN1 LINC01483 HNRNPCP7 LTBP3 SPCS2P4 LRRIQ3 RP11-640L9.1 NUP62CTA-373H7.7 CTD-2165H16.4 IRF2BP1 AHSA1 LIG4 LACTB CDYL AC006994.2AC064850.4 RNF31 RP11-706O15.1 GALNT8 MYLK4 RAB43 TRIM41 AC096579.13C9orf131 CMTM1 WDR11 LSM14B LIMD2 PARPBP AK6 DOPEY1 CLMN CRADD PTPRONCKAP1L RP11-375N15.2 CA11 PTMAP5 CTD-2349P21.5 RP11-368I7.6RP11-1228E12.1 RP11-159D12.6 RP11-677M14.7 RPS11P5 RP11-315O6.1RP11-793H13.3 TMX2-CTNND1 GOLGA6L10 FAM98A TRIM2 RP11-424N24.2KB-1980E6.3 AL022393.9 FNTB TMLHE-AS1 ADO DLL3 CTC-559E9.8 ZNF248 FKBP1APNRC1 CCNG2 SKA2 GAL3ST4 SLC52A1 AC159540.2 WBP2 DOK3 PRDM11 RP4-781K5.2SLC44A1 RP11-139H15.7 RASAL3 IL4R TSPAN9 RP11-167N5.5 RP11-114M5.1 DTX4TRIM26 HIST1H2BE OGDHL DLG1 RP11-379K17.4 HNRNPUL1 DDX46 ZBTB8OS TAF7E2F1 VPS35 RP11-227G15.12 IGHVII-22-1 APBB1IP WDR41 TUBB CH17-264B6.3PAICSP1 RP5-994D16.9 LINC01250 RACGAP1 CTC-332L22.1 GPR153 ADD3-AS1NUTM2B-AS1 LIX1 F8A3 RP11-794P6.1 MAP10 SOCS4 RP4-758J18.2 FBRSAC004381.6 MRPL43 LINC01305 SLC13A5 FAM63B LINC00235 HIBCH AC009120.6CTDSPL2 RPL32P3 PUDP ANKRD12 PGP METTL7B RP13-494C23.1 SMARCA5RP1-60O19.1 CHRNG NDUFS4 SFMBT2 PGK1 NISCH RP11-4L24.4 ELMO2 RYBP DCTN1SNX11 RP11-345P4.9 TSNARE1 PTCHD2 TEC CTD-2527I21.14 SEC63P1 MYBL2FAM107B AC012358.4 AC007041.2 IQCB1 YWHAZP3 BTBD10 RIPK1 PIAS1 MKL1NBPF2P ZNF16 RP11-505K9.4 CTD-2033A16.2 RPS2P46 XRCC6P2 RP11-252K23.2PPP1R12C XXbac- PRKAR1A BBS1 MBD6 RP11-411B10.2 PDLIM1 BPG27H4.8AC097662.2 GNMT PPP2CA SOX7 RP11-93H24.3 HMGB3P22 SCNN1G PPM1L TSSC1-IT1SCMH1 FAM153C LDLRAD2 RP11-525A16.4 RP11-36B15.1 CTD-2116N20.1CTD-2162K18.3 SLC9B1 GNG5 RP11-380B4.3 ZNF274 SYNPO2 CXorf65RP1-265C24.8 LMO7-AS1 AC007191.4 MOB3B STAM RP11-727A23.4 SUMO4RP4-742C19.13 RPL23AP65 RP11-293A21.1 SENP7 RP13-766D20.2 DRAM2 GTF2H2BITPKC FAM3B AC097461.4 RP11-11M20.4 RP11-415J8.3 IFT172 CKAP2L KIF4ACTB-58E17.1 SART1 AC000068.5 RP11-454F8.2 PRH1 SMAD1 FIGNL1 GPD1 LEMD3MYL6 RPS12 AC078942.1 KRTAP5-AS1 SLC45A4 NDUFA3 SIMC1 FEM1A TNRC6APPP1R3E RP11-686O6.2 CCDC142 METTL4 MDM4 AMBP PSMD2 ASNS ZNF329HIST1H2AB SYNPO CEP164 AKAP2 GSTO1 RP11-553L6.3 TMEM177 TMEM263AC006449.2 EIF3CL RP11-823P9.3 N4BP2L2 MAGED4 ZNF428 KRBA1 MSL3 ATP6V1E2RHOQP1 RP1-203P18.1 MAGOHB IRAK3 SLC4A8 LL0XNC01-7P3.1 ANKRD52 ZNF510RP11-1334A24.6 MAFK ANKRD20A11P PEX14 TKFC FOXO3B RP11-707M3.3 TIAL1SKIL ACSL1 IKBKAP SLC38A4 TDRD7 GPRIN1 WBP1L KCTD9P2 TRAC FPGT-TNNI3KCHSY1 RP11-78J21.7 RP5-968P14.2 ELAC1 NAB2 BCL10 FUT1 KCTD6 ZNF610RP11-456K23.1 DAXX CEP63 LINC01578 C21orf2 TNNT1 RBM17 LRP8 PHC2 AKT2TRIM36 EEF1A1P5 SP2 CBLL1 AMPD3 DTX1 ZSCAN20 PXK FANCL SC22CB-1D7.1RP11-156P1.3 SH3BGRL RPL12P37 MORF4L1 RP11-603J24.7 AC004156.3RP11-467D6.1 UBE3D CSNK1G3 SUFU RP11-334C17.3 RHOBTB3 DLEU2_6 HTRA3TGIF1 CTC-559E9.4 FITM2 INTS1 SOX6 AC005307.3 ARHGEF3 PSTPIP1 HIST2H2BCFBXO28 C9orf47 GSTCD ZMAT1 ZGPAT CIRBP RP11-446E9.1 WDR48 CCNT2-AS1RP3-406P24.4 RNF170 PI4K2B RP11-230C9.2 TAGLN2P1 LIPA RP11-53B2.1PLA2G16 APTR NSFL1C AC027601.1 STK4-AS1 LINC-PINT FAM86HP RP1-257A7.5HIST1H4C PLEKHA8 INTS9 RNF6 CTD-2619J13.19 HCG25 RP11-667K14.4 LYPD6BPER2 AXDND1 PELO ZNF350 HIST1H2BO DCAF12 PEX3 RP11-134D3.1 EML2-AS1CTD-2371O3.3 HIPK2 U62631.5 KRCC1 ZACN ZNF738 IL17D SART3 RIMS2 SYNE4LINC01012 WDR47 RP11-325I22.3 STAMBP RP11-96K19.4 AP001462.6LA16c-329F2.2 RP11-763B22.4 FGF11 KLF10 ZNF621 RWDD2A APOF PSMC3RP5-1182A14.7 ST13P5 PARP11 CTC-325H20.4 C10orf111 GS1-44D20.1 DLEU1_2ZNF131 RP11-61J19.5 SKIV2L LL22NC03-27C5.1 KIAA0101 MCM10 ZNF227 SLF1AP001258.4 BRAT1 ZNF688 AC002550.5 RP11-634H22.1 VPS28 GOLGA8OAP000936.1 JPX_1 HIST1H2APS4 RP11-429G19.3 AC083949.1 AC012363.7RP4-669K10.8 KRT8P46 IGHG2 CENPN FZD6 RP11-573M3.3 RP11-818O24.3 VKORC1MTG1 LDB3 TNS4 RPL41 TJP3 RP11-863K10.4 MINA RP11-178H8.7 POTEH TDP1TRIM37 PPIG CIDECP CTD-2256P15.2 SNX32 RP11-111F5.3 DHX32 RPL13ALINC01058 LMNB2 SLC7A6OS RP4-555D20.2 RP11-20I23.10 RP13-650J16.1 GDAP2RP11-296A16.1 AC092641.2 DGCR2 RBMXP2 ST7 CCDC102B TBX19 CTD-2184D3.6MYLK-AS1 ZNF581 ZNF799 SLC25A25 WIPF2 AC112497.1 HIST1H3A C4orf33RHOA-IT1 ZNF252P-AS1 YTHDC1 RP11-166B2.1 SLC35G1 LINC00115 RP11-313P13.5UBR4 C15orf41 PLA2G6 PPP1R15A HIST1H3I CTD-2561J22.2 GNPDA2 ELP5 ZFXRP11-481J2.3 RP11-401L13.4 DCAF13 FLJ37453 NEK7 TCEANC CFL1 HEATR5ASND1-IT1 DNAL4 ZNF710 RP11-140I16.3 TCEB2 RP11-746M1.1 CIT RPL37AC010733.5 MUM1 TOP2A ANKRD30BL KB-1608C10.2 GALNS EMX1 RPS4XP16C7orf55-LUC7L2 CBX5 MAN1A2 KCNG3 AARS PSMD1 C22orf23 MEX3D RASA2AC092798.2 BORCS5 TBCB RP11-407G23.5 PACSIN1 RP11-216B9.6 TUBBP1 ZFP62CTD-3105H18.16 POLRMT POM121B TMEM234 AC113404.1 PBRM1 RALY FNIP2CTD-2293H3.1 GNAI2 ERCC2 POP1 FOXK2 CTD-253719.18 NAGS CTD-2161E19.1SNUPN MESDC1 TMEM182 RP11-181G12.2 ZNF512 SCARF1 PARD6G-AS1 Metazoa_SRPAC012358.7 SIPA1 ZNF322 RP11-261P13.5 GPX3 TRAK2 ZMYND8 NRGN CAPS2PCDHB10 RP11-338I21.1 RAD21 CTC-428H11.2 MERTK AK7 MTMR4 COMMD3 HOMER1FRA10AC1 RP11-958N24.2 BEST4 CTR9 RPL26P30 LEO1 RP11-463O9.9 PSTKCTD-2006C1.10 AC073043.1 TRIM21 KIAA0319 DLX4 TMPO-AS1 KIAA0586ADAMTSL4-AS1 KRT8 MCPH1 TNFSF10 RP11-582J16.4 PHACTR2 LSM11 AC084219.4RASAL2 RP11-134G8.6 DGKA ECI2 CTC-436K13.6 KCNH1 RP11-398K22.12 TRPM2RP11-85G18.6 CKAP5 LDLRAD4 C14orf169 DHX37 IGF2BP3 SHF RP11-29B2.6RP11-417L19.6 LINC01497 RP1-92O14.6 NBPF8 CTD-2550O8.5 ZKSCAN8 EPC2DHTKD1 ABCA2 SPRY3 SPRY3 HIPK1 UXT-AS1 PKD1P1 EAF2 RP11-714G18.1 DECR1RP11-677M14.2 ALKBH8 WDR33 ATXN7L3 AC005546.2 UGDH PLIN2 AC011290.5RNF111 CTBP1-AS MIB1 RP11-195C7.1 RP11-16N11.2 LMO4 HIRIP3 CTD-2033C11.1MDK HLA-DOA FOXD4L6 BRD9 ARL1 PRR3 UBE2Q2P2 CKLF-CMTM1 HNRNPA1P59 ING4NUP93 ZNF175 NUP188 AAK1 AC010900.2 GLRX5 RP11-750H9.5 ZNF740 TMEM55AAPPL2 HIST1H2BG USP39 MAP3K5 MFAP4 AC005062.2 MAFG-AS1 RP11-32B5.1ZNF213 SNRPN RP11-287D1.2 GPR156 TRAFD1 TBC1D3D PRRT1 ITGB5 ADNP2 FBXO10AUTS2 TRMT112 ANKRD33B SLC47A2 DIP2B RP11-54D18.4 RP11-356M20.2AP001437.1 ESYT2 L34079.4 UBR5 RP11-81A1.6 GTF2E2 PRICKLE1 ANKAR SUSD5CDRT15 RP11-341N2.1 LNX1 C10orf88 TBPL1 HSPBAP1 ASF1A TRMT6 PTMA PKMP3RFX3-AS1 AC063976.7 BGLAP H3F3A RP11-242D8.1 RGMA RP11-301O19.1 EXT2RP11-571M6.17 MRPL55 SMAD5 SPDYE8P CAPN14 STS COG4 TAF1C PTPDC1 TNXBCKMT2-AS1 RN7SL23P SAMD4B PIN4 PADI2 ZNF285B TRIM38 GABRR2 RP11-131L12.2FAM173B VWA5A RMDN2-AS1 RP11-715J22.4 HPS3 ANKRD36 TRIM44 TEAD3 RPS2RP11-114F3.4 ITPK1 EIF1AXP1 KRI1 DYNC1H1 RP4-621N11.2 MAGEB6 PDE7A BCRLRRC7 HIST2H2AB CGGBP1 FBXO43 RP4-536B24.4 PGM2 LMNB1 RP11-677M14.3AC093484.4 BLOC1S5-TXNDC5 AP4S1 CDK7 RP11-524F11.1 TBC1D3F FOXP4RP11-792A8.4 CLK2P1 NLGN3 RP11-386I14.4 RP11-552F3.10 TREX2 EMILIN1TTPAL NET1 SOD1 FAM60CP DLEU2 CTD-3222D19.4 LIN54 RP11-128A17.1 RPSAP58RP3-402G11.28 POMK HELZ IGIP KANTR ZFP91 EML3 NXPH4 VN1R83P FBXO5 RPS2P5CDON CNIH4 NPM1P6 CAP1 DUBR HMGB1P1 EBF4 CNOT2 CHRNB2 PAQR8 LINC01278AC007950.2 RP11-158I9.5 HIST1H2AH FNDC3B RP11-154J22.1 RP11-358L22.3DPYD RP11-449H3.3 DND1 SCX HNRNPH3 RP11-830F9.5 ITPKB METTL9 KIF3A KLF6AC016292.3 PBK RP11-43N16.4 CTD-2630F21.1 AC069513.4 FAM222ALA16c-431H6.6 EIF4E2 BCL9L DLGAP5 RP11-67K19.3 PRKAA1 SNRPA GIT1 AMDHD2RP11-533E19.7 TSSK1A FAM220A SUV39H2 ZBTB2 RAB13 RP4-773N10.4 ATPAF1BLOC1S1 TMEM110 GLYATL1P1 ZNF316 CTNNAL1 ARRDC2 TESK1 SPAG9 ZNF142C17orf67 RP11-53B2.5 PTPN23 RP4-569M23.2 LRRCC1 RP11-5G9.5 SPATA25 FKBP9JAKMIP2 CCDC12 KDM2B TERFI SLC26A2 SYF2 IL12A SERINC4 CRTC3-AS1 STK40KHDC1 PCBP2P1 HSDL1 CPAMD8 ZFAND1 RHBDL2 STAG2 RP11-65B7.2 ADM5 RGS1WDR34 RP11-195B21.3 DPY19L1 CEBPB-AS1 WDR70 EBF1 LDHB RP11-294J22.7HLA-J ZNF808 ZNF174 MGST1 FAM19A2 ZNFX1 CTC-457L16.2 CTC-248O19.1 XRN2RP11-283I3.6 CD58 MAPK6 CTC-487M23.5 HDAC2 SLC7A8 RP11-147L13.11 CHD4ZNF425 HDAC9 FBXW5 HYOU1 AC009948.5 HIF1A PDIA2 PLEKHA6 CTD-2532N20.1F2RL3 LL0XNC01-116E7.2 MBNL1-AS1 ROPN1B HNRNPR MATR3 NCBP2-AS1 KIAA0226LHIPK3 NACAP1 RHEBP2 RRAGA KCND1 PURG CTD-2384B9.1 GDF11 C17orf49 FCMRPATZ1 DGKG RP11-181C21.4 EVC LUZP1 H3F3C EP300-AS1 RNF186 UBC PGM1CTD-2619J13.16 CEP295 ZDHHC13 RP11-356N1.2 CTD-2201I18.1 SH3GLB1RP11-2C24.9 CES2 RP11-532M24.1 UBR1 NR1H2 RP11-762I7.5 AKT1 AC074117.10FAM175B ZNF562 C18orf65 CDT1 RP4-734G22.3 RP11-540B6.6 RPL7P21RP11-78O7.2 RP4-801G22.2 RP1-29C18.9 RP1-45N11.1 ZNF544 AMH SNCAIPLINC00638 AC083873.4 NXPE3 ALOX5 TLR8-AS1 WBSCR16 RP11-727A23.5 NFE2L1RAB6B CRELD1 ACRBP SOX12 RP11-51F16.9 IKZF4 ARHGEF19 TMEM135RP4-612B15.3 GOT1 FUBP1 CKAP2 GPR61 ZFP36L1 CATSPER3 COX10-AS1RP11-29H23.7 BCRP3 CXorf40B HOMER2 AC093323.3 NPIPA1 KIAA0556 ARHGEF10CMB9-55A18.1 CTD-2012K14.5 GLT8D2 RP11-119B16.2 AF196970.3 RP11-849F2.5RP11-21M24.2 GZF1 SNHG25 ENY2 FAM172A NUP210L TCF19 ILK SDF2L1 IGLV1-44MED17 RP11-165J3.6 POLR2I PCNT PGBD2 ARFGAP1 ZNF286B CTC-301O7.4 MTERF4C2orf68 PPRC1 NT5DC3 POC1B-GALNT4 HHAT TTC4 AP000275.65 PET117 THSD1PIK3CD KIAA0895 ZNF250 MAD2L1BP RHEB HIST1H1B SLX4 Sep-06 RP11-1023L17.2NSMAF AC004906.3 NAMPTP1 SLC3A2 AC079922.2 GREB1 ARSB HERC4 MTCP1SLC35A1 ACTBP2 CTB-109A12.1 C1orf53 SCAF4 SFXN2 RP11-164P12.3CTC-398G3.2 SP1 RANBP3 PTK7 EZH2 RP11-4L24.3 PARP10 CENPE CALCOCO1 MNAT1AC020951.1 CD99L2 MAP7D1 CACNA1A ZBTB14 MEA1 MTA2 KDM5A CNOT4RP3-466P17.1 NPAT RP11-111M22.5 SATB2 SCD5 RP11-384P7.5 PROSER3 CSRP2EDRF1 JUND ROM1 RNVU1-15 LRP10 RAF1 HNRNPA3P11 PPP4R1 PIH1D2 HDAC7 HGH1CTD-2639E6.9 RPL12P4 GAPDHP62 STK32B MFAP1 CTD-2555A7.3 RP11-10L12.4EML2 KLHL31 RP11-45M22.2 RP3-469D22.1 CTC-273B12.10 HNRNPUL2-BSCL2 WHAMMRBL1 TCN2 CYP2E1 DHX29 ZNF594 LEAP2 AC019097.7 ACIN1 KIAA1324LRP11-360F5.3 HECTD3 EXOC5 B3GNT2 RP5-1028K7.3 RP11-178C3.2 RPS2P55 AMPD2RP11-540O11.1 TSSC4 HIST1H4L SPC24 SNX18 CASP2 C19orf57 USP38 AKR7A3CTBP1-AS2 ZNF48 MKKS FSTL1 ZBTB17 TOP2B CAT HMGN1P38 RBM12B NDUFV2-AS1NUFIP1P MUS81 FAM13A SDF2 RP11-24M17.4 MSH6 AC007463.2 RP11-115C21.2RP11-893F2.14 HMGB1 COL10A1 RARB AP001412.1 POLR3B PFKP BCL7C SDHAP2TCTEX1D2 SOCS2P2 RP11-392P7.1 ACP2 ARSA AKAP12 TMTC4 SENP3 CTC-429L19.3RP11-368J21.3 RP11-325L7.1 ANKRD17 GS1-279B7.2 PRPSAP1 ZNF654 AP5B1WDR83 RP11-274A11.4 ALS2 C19orf44 GPRASP2 FAM204A RNVU1-14 TPM3P8 RHPN1TLN1 RP11-203J24.9 RP11-646I6.6 KDM3B CEBPG PGGT1B GSTM2 SNRPG PLK3RP3-402G11.25 C10orf71 CLEC2D SCML2P2 RP11-110H1.4 AC002059.10RP11-395N3.2 SERINC2 RP11-568J23.5 JMJD6 HOOK3 SUPT5H CCNK RNF139 UBBP4NEIL3 CEP128 ZBTB12 RP11-248J18.2 CCDC81 RP11-421N8.1 CNGA1 CCDC138SNX10 PITHD1 ZBTB33 RP11-176H8.1 BTBD7 RP11-1348G14.8 RP11-264B17.3RP11-75L1.2 AC096772.6 PCAT14 PMS2P10 LINC00665 AC011330.5 H2AFVRP11-435O5.7 PTMS RP11-62C3.8 RP11-10L7.1 LILRB3 SLC22A20 MSANTD4 TADA2BPSMD11 PSMC1 TMC3 NPM1P25 AL023875.1 MTIF3 RP11-75C10.9 STOX2 PRR19 DPCDHIST2H2AA3 BIK DOK1 ATG4A TMEM191B RP11-526D8.11 DNAJC25-GNG10 ZKSCAN4KCNN4 L1CAM ACO1 PRNP AP001469.7 OSER1 PRR13P5 PTPN18 COPB1 UBE2I TVP23CPIK3CD-AS1 RABEP2 TRNAU1AP PPM1E C9orf66 MYH7B ATG10 KIF22 DLEC1 CDKN1BIRGQ RFPL3S RP11-425D17.2 LINC01023 RP1-56K13.3 SPEN CNOT10 NCK1 HERC1ZNF609 NKD1 CDH12P3 CDH12P1 CTPS1 CCDC74B RP11-466A19.7 MTHFD1P1 RFFLMTMR6 RP13-941N14.1 CTC-429P9.2 PDZD11 CENPBD1P1 RP11-701H24.8RP11-498C9.12 ZNF468 RBMX PLCE1 RP11-429P3.5 GPR83 SOCS5 CTD-2619J13.9RAB8B SERHL2 PRDM2 CTB-55O6.8 ZSCAN2 LINC00265 NUCKS1 CROCC PP2D1 SP3ZSCAN16 RP11-574F21.2 TAF4 NOTCH2 LNX2 RNPS1P1 IL4I1 DBF4B XYLT2 SMARCA4RP11-566E18.1 RP11-83N9.5 SPSB2 PRKCH CTD-2207O23.3 RP11-276M12.1 CTSBTMEM18 TXNL1 PHBP9 SYT12 WNK2 PIP5K1P1 SERAC1 MED19 RP5-983L19.2 R3HCC1UBXN2B C5orf56 ADNP GS1-114I9.3 GSK3A RP11-33B1.1 ARMC6 CORO7 ASB3 WASDHX30 ZNF781 MRPS6 RP11-90B9.3 ZFYVE1 RP11-656D10.3 MAPK1 PLEKHM2HNRNPA3P3 DGCR8 HIST1H4I SERPINF2 RP11-536K7.5 ZMYM5 IGLV9-49 DVL2 GLRX3RP11-542A14.1 RP1-41P2.7 SMG8 FAM122C RP11-701H24.4 SP4 RAB21 MKRN2ZNF649 TCF4 COIL RP11-439L18.1 ZC3H13 C8orf59 CCDC174 CTD-2323K18.1RP11-773H22.4 C1DP1 PALB2 ZNF608 TCTN3 TPRN PCDHGA9 HSPA8 RBM22P2 TCEA2SNORA73A SHOC2 POLA2 TPT1 SRSF3 AC004987.9 AC010492.2 ZNF767P KIAA0391SMG7-AS1 NPDC1 RP11-401P9.5 C4orf19 C2orf44 BLK VPS37D ANKRD13C PAIP2MCM3AP-AS1 AGO1 DNAL1 LPAL2 SPIB MDH1B RNVU1-6 RBBP4P1 LIN9 ADHFE1ASAH2B RP11-361L15.5 Clorf116 PUS7L KDELR3 CYCSP34 ULK4P3 RP11-446E24.4CTD-3105H18.18 PDE3B RP11-572P18.1 TBRG4 PHACTR2P1 RP11-275F13.3 ZNF524RP3-337H4.8 RP11-325L7.2 RP11-275I4.2 NFYA EEF1A1P11 UBE2W CCDC66 GDE1INPPL1 ADAM20P1 LINC00152 RP11-255H23.2 PTGES3P1 RP11-977G19.11 ZNF101P2SUPT20H B3GNT8 KRT18P4 RP11-6L6.4 RNF103-CHMP3 CHD2 ZC2HC1A CPQ ZFYVE21NUDT1 LRRFIP2 VPRBP C17orf107 AC018462.2 RP11-111K18.1 TTLL3 CD226LRRC14 DPH3 GTF2F1 ZNF281 RP11-182J1.12 SRRD DGCR14 PCAT6 CYTIPRALGAPA1P OTX1 SMC4 TINCR HTRA2 SLTM VLDLR-AS1 PEX1 KATNBL1 CT45A11PC10orf2 AP1M1 CTD-2666L21.1 SMG1P2 ARHGEF11 NIPSNAP1 C2orf76 ZAP70 BAATRP11-144L1.8 C6orf226 TNRC18 ARL6IP4 RP11-177H13.2 FAM160B1 ATG9A ATP5ERNVU1-4 KSR2 LLNLR-304A6.2 GAPDH RAB11A CYBRD1 ATF4 RP11-213G2.3CTC-436K13.3 ABHD5 SGPL1 LPCAT4 SH3TC1 ST13P6 CTD-2382E5.6 COX7CP1AMMECR1 RP11-276E15.4 UCN RP1-86C11.7 RP11-667F9.1 SCNN1B PAFAH2CTD-2547G23.4 SSBP3-AS1 ATIC RP11-1391J7.1 BRPF1 CTD-2357A8.3 KLHL5 MYNNNFYC-AS1 INSR SENP6 LYPD3 PPP1R12A RP11-390F4.6 MYBL1 ARHGEF25 CEP112RP11-667F14.1 RP11-338K17.5 CTD-2192J16.15 RP11-304L19.11 SCAF11 BRD4FSIP1 PAIP2B RP11-135L13.4 AC007952.5 RP11-533E19.5 AC006538.1AC002056.3 RP11-11N9.4 DOCK2 SHFM1 RNF214 FAM229B RPL35P5 OSGEPL1 ETS1AC094019.4 TGS1 PKM IDH1-AS1 NHEJ1 RP11-108M9.3 CAMSAP3 RP11-147L13.8RNF185-AS1 APC2 RBM22 KCNQ4 FAM161B HMGB3 RP11-344B23.2 PPP2R5CRP11-520H14.7 LRRC29 RP13-465B17.4 RP13-465B17.4 HSP90AA5P TTC34RP11-10A14.9 ARMCX5 OSGIN1 ANKRD36B RP11-755F10.3 CTC-487M23.7AP000350.6 DUSP1 CCDC113 ZBED6 STKLD1 OGFOD2 GHET1 COL7A1 COX6C RBM14UBAC1 RP11-927P21.1 TCL1B LZTS2 RP3-395M20.12 TUG1 HIST1H4JRP11-297L17.6 FAM170B KLHDC3 RP11-394I13.2 INVS ENAM GSK3B NCOA4AC009506.1 FAM111A HNRNPA1 CHMP4BP1 CDKL4 RLTPR AF131215.8 TBC1D15RP11-147L13.14 CFP GDPD3 EEF1A1P19 KDM3A NCLP1 RP11-553D4.2 RP11-390F4.3SOCS1 PLCB2 KCTD9 ATP2B1 RP11-463O9.1 PCDHB9 CDKAL1 SMARCE1 TTC25 SV2ARNF7 TBCC PRL AC110615.1 ALG12 RPPH1 AC092301.3 ECD RP11-629B11.5SLC39A8 MS4A7 CH17-258A22.4 UTAT33 IL6R USP27X-AS1 COMMD10 RNF145 WDR20CRNKL1 MLLT6 TMEM139 SCFD2 ZNF782 ZNF786 TP53RK RP11-173M1.5 STIP1LINC01420 WNT5B HMGN1P36 CLASRP MORF4L1P1 CDK5RAP2 BIRC2 AC090286.2AC006116.22 ZNF529 ADGRG2 PPP1R9B RP11-297B17.2 FUS ATG5 RP11-307L3.2CTB-161M19.4 RP11-649A18.5 NAMPT TUBB8P2 TRIB2 RP11-961A15.1RP11-118H4.1 TACC3 RPL24P8 RP11-849F2.7 RP5-875O13.7 NPTN ANKRD10 LIMS2TPX2 RP4-545K15.5 GTSF1L CROT RP11-153M3.1 HMBOX1 DIP2A GOLGA6L9 RUBCNZNF225 GLYR1 CTD-2047H16.4 UBA2 EXOC3L1 MYH10 HMGA1P2 PSPC1 PHF6RP11-528A10.2 AC002550.6 ITGB1BP1 SEC16B LINC00640 HLA-B SEC61G DMTF1TSPAN10 RP11-968A15.2 DEXI EHMT1-IT1 NUTF2 UBN1 SNRNP200 C19orf43AC006042.7 STRN4 FHDC1 TPGS2 RP11-359E3.4 SLC4A9 RNF122 CLIC6 ATF3RP4-665J23.4 CSPG4P10 NPIPB8 RP11-350N15.5 C5orf60 TBC1D10A KIF18ATMEM231 RN7SL192P PDP1 AC010091.1 ID1 CTA-313A17.2 SLC39A6 TRPC5 PRMT2RP11-1023P17.2 SPRN TIGD5 RP11-488I20.9 ASAH2 RNVU1-3 RAB41 ZNF417CTD-3131K8.2 RPL12P12 COPG2 MANEA-AS1 PRAP1 ARMC5 ACTR10 C4orf46 NOS1APTMEM189-UBE2V1 RPS20P14 NSMCE4A NDUFA1 CENPI PCK1 H1F0 ZNF557 GLYCTKPPP3CB KRT18P5 NOP2 RPS4X RP13-415G19.2 PDE1B RNF8 CYP1A2 PKI55AE000661.37 FBXL5 AC073052.1 PNISR RP11-142C4.4 DDX41 RP1-221C16.8KB-1836B5.1 TECTA RP11-551G24.2 RAC1P2 PPP2CB ALMS1 RP5-1091N2.9RP11-493E12.3 RP3-497J21.1 RP11-651L5.3 PECR GPC5 RIOK2 TMEM56-RWDD3VPS8 RRP7BP PBLD MAP3K11 LYN RP11-159G9.5 ARG2 CWC25 IL7R GLTSCR1LRP11-894J14.5 MRPL52 LINC01176 BCAR3 TUT1 BTG1 IRF2 CEP72 B3GALT1ZNF559-ZNF177 DSTYK PRPF18 FGG NGRN TRIOBP IGLV2-8 USP28 RP11-463D19.2RP11-216M21.1 SF3A3 NUTM2B CTD-2124B8.2 AC005224.2 AL589743.1 C3orf38SUMO2 CFAP58 DYM U2AF2 ABCC11 APBB3 AC074391.1 KANSL1L RP5-1184F4.7GTF3C5 CLASP2 RP11-407G23.2 LY75-CD302 MBD3 AGAP2 RHOQP2 AP001258.5KRBOX4 SMN1 RASSF7 TEX21P ST6GALNAC2 RHBDD1 YEATS4 RPS24 DAZAP1 HPS5C22orf24 RP11-108M9.5 AC027612.1 GSDMD SERPINA10 MAZ RMND5ARP11-492M23.2 NRBP1 DNAAFI NUTM2G RP1-286D6.5 GUSBP2 RP11-279O9.4HSPD1P1 RPL21P110 RARA-AS1 HAGH MAPKAPK5-AS1 TRIM59 IL11RA GGA2 EPHB6FSCN3 ZNF346 NR1D1 RBM15B ZPR1 AC007279.2 EBLN2 ZDHHC16 CSRNP1 VPS18ZBTB11-AS1 RPL12P1 RP11-632K20.2 RPL23AP64 RP11-514O12.4 SOCS6AC079767.4 AC073333.8 SUCLG2P2 RP11-206L10.8 BAD TMSB4X DOCK3 C10orf12KIAA0141 UBL3 IGLV4-60 KCTD10 SUDS3 RPS23 RPL26P19 RINL SFPQ E2F5 ZNF566RP11-87G24.3 ANK2 SNX6 RP11-541N10.3 SRP72 RP11-385F5.5 RP11-536L3.4CTD-2541M15.3 ELMSAN1 ZBTB4 MBTD1 DCUN1D2 IPO8 CDK2AP1 CMTM6 HIST1H3FRBBP9 SPATA31B1P SAR1B RP11-108M9.6 CDR2L ZBTB24 ARRDC1 FKBP1BAC079742.4 TAF3 FGD5-AS1 CTD-3203P2.3 RP11-155D18.13 RP4-545L17.11 KCNH8UHRF1BP1L C1orf74 HPN TSTD2 C9orf85 ACAP1 AC004383.3 RP11-344N10.5S100A13 SLC41A1 ENSAP2 EFCAB12 DYRK1B CNOT3 POLR3D CDC23 DNAJC19P9 RFTN1RHOT1P1 PDZRN3 RP11-297C4.6 YKT6 UBL4A EPHX2 CTC-338M12.6 CH507-9B2.5RGPD1 LRFN3 RP11-140K17.3 SF3B1 LRRC75B FBXO18 SH3PXD2A SLC4A5 HMGXB4RP11-160E2.11 TCAF1P1 RP11-475O6.1 RP11-572O17.1 CHST12 SPARCL1 ZC3H3RP11-112J1.1 UBE2E3 PAPOLA LINC00539 RP11-313D6.3 ZNF85 WARS2 CLDN11RP11-147L13.2 STAM-AS1 RP11-680H20.1 EIF4HP2 RP11-434H6.6 AVEN ZNF442AC000078.5 RP4-675C20.4 XKRX PFN1P2 BMS1P22 EBAG9P1 ZNF574 KB-1980E6.2AC062028.1 ULBP2 RP11-25K21.1 CFLAR-AS1 RP1-283E3.8 RP11-371A22.1RPL23AP42 CHD5 CTD-2319I12.4 NAT14 C1R GABARAP TPRA1 COPZ1 WHSC1RP11-810P12.7 CTD-2054N24.2 GLRX3P2 CHD6 ANP32A TRIM52-AS1 PAFAH1B1AC004069.2 RP11-369G6.2 DHX8 OR7E7P FZD7 CCDC88B RP4-814D15.2RP11-347C12.12 SMAD1-AS2 CTB-31N19.3 CECR5 HIST1H2BF BRMS1L CSF1C2orf27A LMF2 MGAT5 C4A HNRNPK XXbac- RP13-580F15.2 ALDH4A1 ROCK1P1BPG294E21.9 ADH5 BRAF RP11-542H15.1 MAPKAPK5 RP5-875H18.10 KDM2ACTD-2341M24.1 WWC3 MKL2 MGEA5 RP11-560J1.2 PARP2 RP11-727F15.9 FKBP8C8orf76 TIGD4 DDB1 KHDRBS1 FAM9C PCM1 MBNL3 UBA6-AS1 LCP1 SLC16A9 USP1CTD-2027I19.2 RPL13AP25 PAN3-AS1 CD38 FOXD4L5 CCDC144CP C14orf93 TEX10BOD1L1 AC068831.10 CTU1 RP11-373N22.3 CTD-3220F14.3 SERTAD1 LCORL FTLP3MRPL1 RBM19 PDCL AC024704.2 C1orf95 ZNF121 RPL31 PPP4R3A PTPRF FAM234BZNF207 ZBED8 RP11-104N10.1 KPNA2 TSTA3 AP000442.1 FKBP5 KLHL42 NUSAP1FLJ21408 NUMA1 RP4-756H11.3 RP5-1092A11.5 ZNF532 RP11-426C22.4 PHACTR1C16orf89 GNRHR CDK3 AC147651.4 IGHV4-34 CAHM RP11-85A1.3 ADRM1RP11-133K1.11 MCM2 RAD54B ZNF232 CC2D1A TMEM238 TNFRSF25 NONO LINC00623CHCHD4P3 AC073254.1 TOP1 SUPT6H HSP90AA1 DDTL LINC00933 BICD1 FAM118BRP11-96K19.2 RPA1 PPP1R35 SLC28A2 NUDCD1 RP3-322G13.7 CRTC3 RBP5 C9orf40CAPN15 N4BP1 ZBTB22 ALG11 MYO9B CTD-3113P16.11 POLR2C SCARNA2 SUMO2P1RP11-245J9.6 YIPF5 ENO4 CTD-2231E14.2 AC097713.4 COQ5 IFT43 CSTF2RP11-144G6.12 GSDMA SLC25A43 UQCC1 PSEN1 THEG C1orfl32 MORC2 SKA1 ZNF8CACNA1C-AS2 MECR RP11-173P15.9 MMP25 GPX4 C2CD5 TARS RP11-98J23.2 ZNF275GNB2 CTB-47B11.3 RP11-178L8.4 EHBP1 KIF1C AC093838.4 RPL5P18 ZNF33BTCF7L1 PEX2 RGS9 GAB1 ALCAM RP11-366M4.11 WDR44 DTL ZNF565 ATF4P3LA16c-360H6.1 SCYL2 MOK RP11-157P1.4 ERMARD RPL35AP PRRC2A MIOS UBE2SP1SELV MPRIP-AS1 RP13-16H11.5 AD000864.6 GATSL3 GPSM2 CCDC97 CTC-425F1.4CRP CDK8 CPSF6 RP1-37M3.8 IGLVI-70 RP4-583P15.14 MMS19 SESN3 AC006509.7RP11-562A8.4 HSPA8P7 ERBB4 TUBB2B MKLN1 GBE1 NUB1 RP5-1125A11.7 RSPH14PPP1R1B ARHGEF18 CHAD RP11-160H22.5 ZSCAN32 RP11-379H18.1 RP11-285J16.1CDC25C RAB39A AP000476.1 LINC01372 FAM21A NDC80 TP53TG1 CACNA2D2 CISTRADRB2 CLSPN RP11-428J1.4 MMP7 MGMT PDK1 UBA6 TMC4 NUDT5 ZNF778 SLC37A2PARL TRAPPC1 RP11-87H9.5 ITGAL BEND3P1 XXbac- SAA1 RP11-464F9.22 ORC6CAPRIN2 B476C20.9 AC007256.5 PRMT7 CHAF1A FAM71D MGAT1 ZNF233 GMFGIGLV3-19 UTP18 SMNDC1 FOXD4L3 TMEM123 PIGY WDR89 RAP2C-AS1 PITRM1-AS1APOE CLTC IGKV1-12 SPECC1 CH17-437K3.1 RRM2 MIATNB HIST1H2AK ANKRD11RP11-466H18.1 TTC37 SEMA4D KCTD21 ORMDL2 CEMIP GPR39 PLEKHM1PCTC-471F3.5 IRX5 TMPO ZNF345 KCTD18 CAMK2D PRKCQ TMEM86A SNORA63RP11-96L14.7 TRIM39-RPP21 NDUFA4 LINC01251 KLRC4-KLRK1 BTN3A3 SEL1L3NUDT3 IGLC1 USF2 HEATR5B SAE1 CTD-3138B18.6 MIER3 GPATCH11 OCIAD2CTD-2192J16.22 AC104134.2 RP4-620E11.8 CTCF RP1-43E13.2 RP11-57K17.1CCDC80 RP11-21L23.2 C5orf28 BCCIP ZNF280C GAA RP11-119F7.5 EFCAB5RPL24P4 CIC SLC38A2 RP1-168L15.6 MMACHC C8B PIFO ERAP1 GAN FHL3 ZNF672AC009060.3 LRRC40 PLPPR2 FCHSD2 GOLGA8IP RPP38 TBC1D9B KIAA0196HIST1H2AJ DNAJB1 SPATA3-AS1 IGKV2D-30 SFTPB CDCA8 RP11-334E6.3 HMGB1P5ABHD17B AC142472.6 MTND4P15 CMBL RP11-1105G2.3 LMBR1L CIZ1 ALDH1L2POMGNT1 AC138969.4 ALOX5AP ONECUT1 ARID1A BMPR1APS1 HS1BP3 PRKYRP11-385F5.4 SMIM5 TTLL11-IT1 FANCD2P2 ZNF3 FABP1 PPP1R12B DHODH ATP10BTRIP4 GIPC1 RP4-761J14.10 THUMPD2 CCAR1 LRRC42 TBC1D10B MEF2CRP11-61A14.4 RP11-331F9.3 PLCD4 CPM SMARCC1 KIF23 NIN PHKB NBPF25PRNF139-AS1 GUSBP4 IGKV3-11 MIR497HG RP11-332H18.3 AC068831.6CTD-3252C9.4 HSPA5 NCAPD2 COMMD7 AC004471.9 CDC26 ING3 APC SPTB SERPINB6ZNF449 RP11-94I2.4 SETD5 HOXA3 SSRP1 RPL7AP10 BBS10 RLF KLHDC4RP5-1073O3.2 KIAA1524 AC005682.5 AAED1 MED23 CTD-2649C14.2 RP11-326I11.4C17orf89 CROCCP4 RP11-289I10.2 DSCR9 IK EIF1B RP11-22B23.1 RASSF1-AS1DDIT4L TARDBP TMEM108 HNRNPM TTC7A ZDHHC17 XXbac- RP11-290F24.6 YIF1AAMN1 BUD13 B444P24.13 DDC LSP1 AC006994.1 SBSPON SHKBP1 KB-1592A4.15RP11-84C10.4 RP11-329A14.1 CTA-246H3.11 AOX2P EIF3FP3 ZSWIM3RP11-46J23.1 CTC-524C5.2 LDAH MYO1H RP11-644F5.10 GPR108 YTHDF3 UBB WTAPNPM1P37 RAD54L2 TRUB1 RP11-662J14.2 HNRNPC CDS2 ANAPC7 RP11-545M17.1ZNF706 SFXN3 CLECL1 RP11-264B17.4 RP4-753P9.3 ARL6 HIF1A-AS1 CD79AGPR146 AC138035.2 RP11-108O10.8 RNU1-28P RNU1-27P RNU1-1 RNVU1-18 RNU1-2RNU1-4 RNU1-3 U1 U1 SIAH1 SCNN1D RP11-798M19.3 FHL1 RP11-313J2.1 RAB8ASYK PUS3 LRR1 KIAA0232 RBM39 RP11-396C23.2 SMG9 PAQR7 RPSAP54RP11-113D19.9 CTD-2619J13.14 SCARNA5 CCDC127 RP11-534L6.3 DNALI1 RPS20ZMYM1 ANKRD46 GALNT7 PDE8A TMEM64 YTHDF2 RAB5B RP11-615I2.6 PARGRP11-174O3.1 KRT10 UBQLN1 IGLV1-40 POLL RP11-35J23.1 RP11-215A21.2RP11-126K1.8 MOSPD1 AC002117.1 SCRN2 CTD-2260A17.1 NEXN RP11-252C15.1RNF40 CTC-499B15.5 G6PC TP53 GCC1 MAP3K9 ZNF517 RP11-298I3.3 PTMAP2 PHF3CCDC9 SLC25A1P5 GLUD2 RP11-152H18.3 CHGB CLINT1 ATP5G2 TIGD7 AC025335.1KB-1208A12.3 RP11-297C4.1 RP11-305O6.4 RNF38 UNC5CL TERF2 KANK3HNRNPA2B1 AC078899.1 RP11-517B11.7 MARK2 RP11-44N11.2 RP1-118J21.25RP1-63M2.7 RP11-785D18.3 RNF103-CHMP3 CMSS1 RNU2-63P ARL15 HEATR6CTD-2021A8.3 MAFA GPR174 CTD-2270P14.2 HYLS1 RER1 RP11-252A24.2 SLX1BMBIP FIBP TOLLIP-AS1 ZNF43 ASNA1 ZNF419 LRRK2 C5orf34 TATDN1P1 PODNL1CTD-2006C1.2 RP11-286N22.8 CTD-2540L5.5 SELK SIM2 AC073046.25RP11-816J6.3 DDX3Y FAM46D TEF TINF2 FSIP2 RP11-717D12.1 SEC31B PCDH11XRP1-159M24.1 SCARNA16 C9orf147 KIAA0922 PTK2B RP11-552F3.9 DCLRE1B PHF1UBE4B RP11-730G20.2 RP11-253A20.1 ENTPD1-AS1 RP3-508I15.22 RP11-386M24.4TAX1BP1 RP11-304L19.13 OPRL1 C19orf68 DBI WASH4P AC022210.2RP11-361L15.3 SPC25 ZEB1 ARL5B POLR2J4 YBX3 PLXNA3 RP11-805J14.5LINC01003 CTD-3199J23.6 CTD-2192J16.26 AC007405.6 C15orf38-AP3S2 PHEXRP11-365F18.6 C10orf95 NFE2L2 ERI2 SNRPFP4 NPM1P39 RP11-343H5.6 BTBD10P2ASCC3 IP6K2 KCNN1 MLKL ACYP2 RP4-784A16.2 CPSF7 RP4-539M6.22 PCSK5 ARRB1TRAF2 CCP110 EEPD1 VCP NME1-NME2 RAB28 AC020743.3 PLS3 NOTCH3 EPC1 PCCACNOT6 IGFBP4 PCBP4 RP13-942N8.1 SCRG1 GMIP NUP155 RHOG VDAC1P2RP4-724E16.2 GNB1 YWHAQ SLC16A7 LINC01183 H2AFY2 RP11-480G7.2 RPS19BP1NUP153 TNFRSF10A CAPZA2 POM121C LINC00310 ZNF211 RP11-724O16.1 SVIL-AS1ZNF273 RP11-173A16.2 RP11-712L6.7 RP11-170K4.2 RP4-583P15.10 RAD9B PCLORP11-455F5.6 C2orf49 CTD-2524L6.3 RP4-622L5.7 PBX1 AP001469.5 AC083884.8CERS1 LINC00954 LRRK1 ZNF569 RP11-245C17.2 DHX40P1 RP11-455I9.1 RUFY1DSCC1 ARL6IP5 RP11-459F6.3 IGHEP2 ZPBP2 WDR62 RFX3 EIF4A3 PRMT9AC079448.1 MAT2B RP11-285G1.14 MTCYBP18 LL0XNC01-240C2.1 RP11-68I3.10INTS12 SLC7A5P1 TOE1 RP11-574F21.3 ADPRM AC007566.10 FNBP4 CDCA7LRP11-495K9.5 CHD7 NNMT RBM10 CTC-277H1.6 FAM98B DNTTIP2 ZMYM4RP11-843P14.1 AC007906.1 FAM168B RP4-756H11.5 SLC4A1AP RP11-108M9.4ZNF607 TESPA1 RPL21 G6PD RP11-164H13.1 PRAME ARHGAP6 KIF3C AC006129.1AFF2 NHLH1 SAYSD1 FNTAL1 KIF14 BMF RP11-3P17.5 TRMT12 AC006116.13 DDX20RP4-803J11.2 SPPL3 ZNF408 RP11-147I3.1 ZNF776 CTB-50L17.10 RP11-22OI1.2ARRDC3 CTC-529I10.1 RPL39L EIF3EP1 ZHX2 AMER1 RPL26 RP11-353N4.6 MDH1LINC00526 ATXN1L ZEB1-AS1 MINOS1-NBL1 TTLL9 ZNF143 RNF219 TSC2AC005775.2 ZNF337 NINL AMBN CCDC7 CTD-2544H17.1 RECQL APOLD1RP11-532F6.5 SALL2 ACTR5 CAND1 AP005901.1 SPSB3 RP11-305M3.2 GOLGA3RAD23B SLC25A47P1 YWHAZP4 PSMD14 C1QL4 ESPL1 SNX30 NBEAP3 RP11-463O12.5RP11-35G22.1 RP5-1042K10.14 NDUFA9 MXRA7 RP11-10L12.2 RP1-283E3.4 XXbac-ABCC1 BPGBPG55C20.1 WIPI1 CRIM1 FRG1BP RP11-173E2.1 ZNF431 CCDC157 CPNE1HUS1B CTB-4E7.1 ALAS1 DIAPH1 PBX2P1 RPL10AP6 AGPAT1 ORMDL3 CDC5L NPM1P29SPATA9 RP11-490H24.5 RP11-347C18.1 RP5-1142A6.9 RMRP TNKS1BP1CTD-2313J17.1 RP11-10N16.2 MSNP1 RWDD4 EPHX3 ZNF385C RP11-368N21.5RPS23P8 MED1 C11orf68 RP11-177C12.4 CTD-3075F15.1 RP11-488C13.7 SLC35B1HLCS RN7SL832P RP11-613F22.6 EID1 RP11-295H24.3 RP11-231G3.1 AMIGO1CPSF3L REPS1 RP11-138I1.2 QSOX2 SMG6 MAP2K7 AC015849.13 IER2 SYNGR1 KLC4SFMBT1 RP11-256L11.3 WTIP TAS2R50 RPS29 RP13-516M14.2 AC097495.3CTD-3138B18.5 ANO1 C17orf100 TRAIP ABALON SRPK3 EIF1 PDIA4 PFDN4 SPIN4TNPO2 ALDH1A3 RP11-449P15.1 SH3D21 KATNBL1P6 LGALS3 SCARNA7 USP51RP11-552C15.1 LASP1 XRCC2 SORBS1 CCDC15 MED9 PDE1A AP000866.1KB-1125A3.11 ZNF865 ACTL10 NCAPH RP11-68I3.4 MORF4L2 CTD-2184D3.7 MZT2BMMP19 RP11-370B6.1 HYAL1 PTGES3P3 AP000577.2 ASCC2 Sep-05 LINC01346TMEM191C SPATA20 RP3-512E2.2 EFNB3 AC108479.2 PRDM10 TRAPPC12-AS1RP11-69L16.5 ZUFSP RAB33B BAK1P1 GPA33 MMRN2 TXLNA CUL4B RP11-715J22.3ZNF32-AS1 FAM134A RPL34 ZFP64 CSNK2A1 IFITM4P RP11-259G18.1 FAM180BRP11-173B14.4 EXO1 RP11-158M2.3 MLEC AATBC RP11-862L9.2 TBC1D13 ZFATUSP9Y FLJ13224 PCDHGC5 AC018766.4 RP11-486G15.2 SLC25A18 IPO5 RAB6C-AS1QPCT RP11-414C23.1 RP11-288K12.1 NDUFA5P11 COX7C CSTA CYP2D7CTD-2369P2.5 TMEM200A MGAT3 ZNF184 RP11-755B10.3 AC012368.1 EXOSC10HPCAL4 RP11-347C18.3 FLVCR2 RP11-546K22.1 NFKBIA RP11-679B19.1AC017074.2 FRRS1 RP11-482D24.3 GJA9 PHAX CXXC1 RXRA SUZ12P1 ZNF627 CPSF2LINC00657 TTBK1 PLEKHA3P1 LRRC37A RP3-375P9.2 SLX1A HUWE1 RP11-70L8.5CBX3 PLCB1 ABHD3 RP5-1057120.6 RP11-455G16.1 GTSE1 FPGT RAB11FIP5RP11-131M11.2 FOXO4 RP11-1137G4.4 CSDC2 ZBTB8OSP2 RP11-548H18.2 EIF4G2DYNLRB1 BBS12 TVP23C-CDRT4 RP11-572M11.3 ARID5A MEGF8 GLYATL1P4 NFKBIDCTD-2509G16.3 RP5-1024G6.5 RP11-12D24.10 EVI5 RP11-550I24.2 IGHMBP2APOA2 CPEB3 RP1-20N2.8 RUNDC1 HS3ST3B1 THOC5 DCLRE1A RP5-875O13.6AC137932.4 GNAS CTD-2035E11.3 METTL21A SMC2-AS1 PPP1R18 SLC39A13 FAHD1PROM2 RPL10 PLEKHG5 AC018755.17 AMD1P3 CYP26A1 CCDC107 AC007325.1 ATAD3ARP5-827C21.6 TTC28-AS1_2 SNX2 PCBP2-OT1 HSD17B1 CCDC71L MAP4K3 STK16CSPG5 CNOT8 NDUFS5 AP004290.1 FGB PARGP1 DEPDC4 RP11-981G7.6 CDKL3 ZPBPRP11-923I11.3 NADK CENPJ RPL7AP60 RP11-325L12.5 IGKV2D-26 CFAP45 NPIPB5AC003090.1 GUCA1A TCOF1 SH3KBP1 CDKN3 ZNF846 LL21NC02-1C16.2 RPLP1P11CCL3 ZNF571-AS1 ALDH5A1 SMAD7 RP11-950C14.7 RP11-347C12.4 RP11-345J4.4DBN1 GS1-590J6.3 RP11-209D14.4 KLF3 HNRNPDL CYP2A6 LONP2 MTF2 MTCO3P11PMS2P2 CPT1C ATF7 TRIM34 GTF3C3 TTC39B RP11-752D24.2 RP11-468E2.1 KDM4AKAT2B RP11-44N11.1 PAPOLG PSMA3-AS1 ITGB2-AS1 ANAPC1 SHISA9 AC090498.1TTC22 OVGP1 BICD2 RP4-569M23.5 AC009120.3 IGHM DROSHA STK31 HELLS CASQ1RPS3AP2 DNAJC13 LDHAP7 ZNF543 PRDX3 TTC16 FAM20A RP11-57A19.2 TWISTNBSLC38A1 WAC-AS1 FTH1P11 MSMP HNRNPD AC004556.1 RP1-20B11.2 AC073842.19TMEM204 PRELID3A RP11-388C12.8 SULT1A3 RP11-287F9.2 IFFO1 AC016734.2ZNF436-AS1 SPON1 RPL10P15 KRT18P28 P3H1 RP11-548H3.1 MARK3 CTD-2246P4.1AC090587.4 HADH STK26 ARX ENPP5 DCAF5 LRSAM1 NPIPP1 CCT2 AURKC SEC14L5PSMD9 SIRT4 CDC42 FAM218A ELK1 RP11-49O14.2 RPL6P27 SRF RP11-435O5.2RP11-847H18.3 CTD-2591A1.1 KLRK1 RP11-777F6.3 HSPE1 SUMO3 HOXA1 MDM1NSG1 SMIM10L1 FGA HEIH ALDOB ZKSCAN1 AF129408.17 CHRNE Metazoa_SRPRPS6KL1 HCP5 UVSSA HSPE1-MOB4 LRRTM2 FDPSP7 RP11-440L14.4 RP11-314A20.1FGF13 FBXW7 TFAP2E RP11-671J11.5 NARFL MTMR1 F8A1 RP11-531F16.4 USP7AC093074.1 DNAH10 UBE2F LINC01374 GAB2 ARID2 SPNS3 KCNK13 EIF1AY CDCA7TSKU AC005606.14 CDK9 PHF23 PPP5C BTNL3 RP11-282K24.3 RP11-134D3.2CTA-223H9.9 DCUN1D4 HSD17B4 EPM2A NDUFA13 AC000123.3 RP11-482M8.1RP11-192H23.5 FTH1P3 ETV2 RCBTB1 SEC13P1 AE000662.92 LIMS3L EIF4A1P7CDC6 CAMK1 RP11-464D20.2 ZNF385B RN7SL15P KDM6A SOS2 RP11-730K11.1RP11-152N13.5 SNRPGP15 TWF1 RP5-956O18.2 TUG1_1 SAP130 LINC01119 DEPDC7AC022007.5 CTC-260E6.2 RPL13AP5 HMGN2 TRIP12 RP1-39G22.7 GRIPAP1 NXF1PHLPP2 C18orf25 FAF1 RPL12 RP13-753N3.1 RP11-48G14.3 VPS50 UPK3BL TADA3C1orf174 EID2 RP11-195L15.2 C11orf58 TRNP1 RWDD3 RP11-350J20.5 NDUFA12CTD-3220F14.1 DYNC1I2 ZNF519 TNPO1P1 RN7SL381P AC093166.1 RPS11 NUDT2SNRPD3 PPA2 CLPTM1 CTD-2192J16.20 CFL1P5 ATG16L1 ZMYND19 ZNF236 SMC2CYP3A7 ENHO RPL39P3 ATXN7L3B CAPN3 BUB1 RP1-257A7.4 CLIC4P1 KDM5C FAM83DUBE2G1 GRTP1 GIT2 TCL1A CTD-2235C13.1 SRPRB GNB3 AP1G1 FEM1B U2AF1L5RP11-54O7.1 DYNC1LI2 KLK1 SYT7 C12orf29 SRA1 RP5-935K16.2 SRBD1AC079807.2 DBNL C1orf54 RP11-583F2.2 DNAJC16 RP11-571I18.5 FRMD8 RANCOPZ2 INO80B-WBP1 POC5 IRF3 RP11-589P10.5 RP11-420A23.1 LRRC46CTD-2555A7.1 RABL3 HNRNPA3P5 RIMBP3B C6orf62 RP11-95D17.1 AZIN1-AS1RP11-346C20.3 SPAG16 RP11-460I13.6 PAIP1P1 CRABP2 RP11-368P15.3 TOPBP1SNX18P12 TMEM183A RP11-662J14.1 USP14 SPATA4 CTC-493L21.1 SLC25A39HNRNPA3P6 RP11-839D17.3 STUB1 HMX2 TRERF1 XRCC3 RP5-836N17.4 ABHD13TRERNA1 RP11-181C3.1 UBE2Q2 MEIS2 RBM42 C11orf80 SYCE3 RP11-64K12.4MALT1 IGKV2-29 C6orf132 GCLC GDI2P2 RP11-408P14.1 RIMKLBP2RP11-1157N2_B.2 ZFYVE16 FLJ31104 CASP8AP2 GPC6 LINC00304 GNE FTOP1 FGD4BBS2 RP11-669E14.6 RP13-33H18.1 PPM1J FXR1 RP11-520A21.1 AC004837.5 ATE1UBL5 NAALADL1 STRADB CDK13 PTPN2P2 CSNK2A3 STIL CTC-490E21.10 S100A14NRIP1 RP11-640N20.4 ST6GALNAC4 ADH1A NMT2 CRYZ CTD-2006H14.2 TSPAN6CTC-296K1.3 KCNJ11 TRPM4 RP11-367J11.2 EXO5 TOPORS ATP8B3 GGT5RP11-659E9.4 RPL8 RAE1 CTA-280A3.2 RP11-706P11.2 RAB6C P2RX7 PNMA6A CLMPRP11-793H13.10 AC005780.1 RPL3 COX10 FAM27B GTF2IRD2B HSD17B10SC22CB-1E7.1 TUBA3FP ZFPM1 TUBB8P12 KNTC1 RP11-240G22.4 BRF2 ENTPD7 RCN3FAM179B H2BFS STAU2 RP11-247A12.2 MESP1 KDM8 RP11-1193F23.1 POLDIP3 PI16PEX11G CNOT7 SERPINB9 AL133243.1 RP1-315G1.3 RP11-434D9.1 CALM2 ANXA4METTL10 RP11-889L3.1 SNHG7 RFC4 RPS15A EFCAB7 VPS53 CCDC88A PTTG1 BDH2P1RP11-365F18.3 CICP22 RP11-390E23.6 NGFRAP1 COX6A1 SCG5 CFAP53 GAPDHP38SNAPC2 RP11-148O21.2 RP11-501C14.5 RTEL1 TACR2 RP11-961A15.3 PPP2R3AANKRD65 RPS9 H2AFZ SLC26A4 NT5CP1 PLCD1 RPIA PSMD10P1 SUCLG2-AS1 SPAG5ARFIP1 CTC-448F2.6 RP11-257K9.8 SLF2 HNRNPH2 RP11-494O16.4 SLBP MCTS2PMIA EEF1B2P3 RP11-824M15.3 RP11-74D7.3 RP11-175D17.3 GTF2IP1 TMEM221PIGH CCDC14 CTB-33O18.3 RAD51L3-RFFL RP11-214N9.1 FTH1P7 BAZ1BRP11-758H9.2 VRK1 ZNF784 EIF4EP1 RAB2B CRY2 ZNF506 RP11-391L3.5 SPINK13QRSL1P3 RASGRP2 SEL1L ARHGAP32 CTD-2659N19.9 RP11-977G19.12RP11-326K13.4 FGFBP3 RP11-474P2.4 ZDHHC11B GINS2 HSPE1P3 CTD-3037G24.3PRPF6 ZMYND12 XXbac- RP3-394A18.1 RFC3 B135H6.18 AC008592.3 NDUFA9P1AC007246.3 RP11-758M2.1 RP11-656D10.5 NDUFS6 NFIL3 RBMXL1 CCDC28A ZNF630IGHV3-72 RP11-461L13.3 RPS3AP5 APCS ACTR3B PAM METAP1 SMPD3RP11-571I18.4 RP11-88I18.2 CTD-2370N5.3 USP32 SDHAF1 RPS15AP16 VEZTCHST10 CAGE1 AC012513.4 RP11-326C3.16 MFSD3 URM1 CYP39A1 RP11-204C16.4MAP4K1 PKP3 CLEC4A IFI6 TMEM159 CIDEB RBMS1P1 RP5-943J3.2 MCM6 SOX2-OTGPR87 FRMPD1 MED21 GTF3C6 ABCC9 CTD-3105H18.8 RPL10AP2 FOXD2-AS1 TLR4GPN1 RTCA-AS1 AC115617.2 ZSCAN21 RP11-110J1.2 RPS18P9 DHX40 AC109829.1TRIM6 FXYD3 CCNB2 AC016739.2 HACL1 GPR65 GRWD1 TTLL11 HNRNPL CHAMP1RP3-437C15.1 BHLHB9 NEURL4 CDC42P4 TRAF6 UBD CHL1-AS1 ING1 C12orf65LINC01554 CTD-2145A24.4 ZBTB40 RAB3GAP2 RP11-457M11.5 HM13-AS1 CDCA3PHBP6 DIAPH3 AUNIP RP11-122K13.12 SPATA5L1 TATDN1 SGOL1 NPLOC4 ARHGAP18U1 ROGDI ARPC3P1 BACH1 NOS3 RP3-388N13.5 KIF2C ARL14EP RP11-318C24.2 TTRRP5-864K19.4 CTD-2235C13.3 ZNF212 RP11-665E10.5 RPUSD1 CTD-2554C21.1RP11-629N8.5 TERF2IP CD109 NR2C1 SCLT1 MAX TMF1 TEX22 PEBP1P3 MYH15PIP5K1C CTD-2325M2.1 AP003391.1 SET RP5-1047A19.6 MAN2A2 RP11-575L7.4YBX1P10 BABAM1 RSRC2 COL1A1 FKTN RP11-566K19.5 BZW2 DHDH CLUHP3 MGC16275RP11-261P13.6 TNFAIP1 TEP1 DDX11 PKD1L2 FAM35DP FBXL19 JOSD2 RPS18P12CTD-3099C6.11 C17orf80 HEXDC-IT1 VPS51 AC144652.1 U2AF1L4 MAPRE3RP13-270P17.2 ZNF436 CSTF1 RP11-351C21.2 RAB3GAP1 CTD-2583P5.3 CARS-AS1RP11-700P18.2 NEDD8 SETD6 ACADVL ATP2C2 FAM185A CDC14B SPECC1LRP11-345J4.6 CTD-2619J13.8 CWC22 SMU1 TMEM5 SCP2 EIF3D ERF XRCC6RP4-536B24.3 SNF8 CCDC90B SAP30L RP13-20L14.4 GLYATL1P3 DNAJC14RP11-517I3.2 CTD-2537I9.12 KAT7 SPAG7 RP11-203F10.6 BNIP3P5 C2orf81TUBB4B RP11-795F19.5 BSDC1 RP11-196B3.3 CCNA2 CTD-2619J13.13 SNX12FTH1P16 RP11-817O13.9 AARS2 E2F3 CD2AP RP1-234P15.4 SDK2 GUSBP11 ARL6IP1PPIAP16 RSF1-IT2 RNF187 HTT CDC27 RASD2 FOXO3 HPRT1 MAPK7 RP11-727A23.10ADCY1 RP5-1056L3.3 ANAPC4 LINC01266 NRAV TMEM19 AC009950.1 GLMN SNX6P1NAA60 EIF3L RP11-317N8.3 NDRG1 DNAJB7 RP11-311P8.2 RP13-582O9.6 PSTPIP2AQR RP11-12A20.7 C12orf4 NRD1 NRBF2 CTD-2215E18.1 RPS3AP47 RP11-87C12.5CNFN IQGAP2 ZNF652 AC015987.1 JAG1 RP11-251G23.2 RP11-98D18.15 TAS2R4SFSWAP STX17 SNORD3B-1 HHIP LTA4H CCT7 RPS19P3 RP11-315I20.1 STX8 APOBGLIPR1L2 MIS18A AC007308.7 SNX9 GSKIP RP11-219B4.3 CTSV ARMC8 AP1ARAC015971.2 IFNGR2 NAT16 CHCHD2P6 PNRC2P1 ZCCHC6 FAM35BP RP13-93L13.2CTD-3220F14.2 CTD-2509G16.5 RGS17 SCAF8 REPS2 KLHDC2 RP11-435J9.2 CCNIKCNT1 CTDP1 DVL3 CHMP4B RP11-1017G21.5 MAGOH DTX2 SHISA3 CHL1-AS2FAM109A KLHDC8B RP11-235E17.2 TWF2 CRTAM RP11-262H14.5 TTYH3 AC114730.11FBXO7 TMEM74B NRF1 RP11-376N17.4 RP11-191L17.1 AXL BCLAF1 DPH3P1RP11-5C23.2 C9orf116 ZNF444 KAT6B RP11-406H23.2 YOD1 CSAD LDHA CASP3VPS13D IARS TCP11 ICA1 RP1-101A2.1 RPARP-AS1 PPWD1 MRM1 CTD-2510F5.4AC004453.8 ATP1B1P1 SFI1 TPRKBP2 CBFA2T2 LPP-AS1 LSM8 RP11-417F21.1RP5-890O3.3 TMEM266 TRIO ARHGAP22 AP000569.9 CFH AC009120.11 HAPLN2OSCP1 NXT1 AC068831.16 C6orf48 SLC25A5-AS1 DYNC1I2P1 UBAP1 CYFIP2 NNTDMC1 ZCCHC5 INIP CTB-50L17.16 MAPK9 KIF7 STAG1 PTPRN2 RPS7P3 FSCN2FAM189A1 RDX FBXO22 RP5-881P19.7 TSPYL1 SLC30A9 PREP ITPR1-AS1 SPACA6PSEC16A TRMT2B CCDC144NL-AS1 LINC00479 COPG1 RP11-797A18.6 KBTBD4RP11-34P13.16 HAVCR2 RP4-796I17.5 RP11-214K3.21 EIF4A2P1 ACTL6A MOGSDNAJB9 BX842568.2 RP5-940J5.3 RP11-61L19.3 RPL28 CDS1 CAPRIN1 LINC00958RP11-160E2.19 SERF1B RP11-481J2.4 PPP1R36 RP11-275I4.1 SLCO3A1 YBX1P2UQCRBP1 PRKX USP6NL OAF GPRC5A UBXN7 TMEM39B BMS1 UBXN2A RP11-334L9.1LAGE3P1 FBXO11 ATR STXBP1 RP4-680D5.2 SAPCD1-AS1 AC006116.20 DNAJB2 BRD3PHLDB3 ARMCX4 SHPRH CEP76 TSNAXIP1 RABAC1 RAB40A TOP3A FERMT2CTC-308K20.1 DEPDC5 RPL39 RP11-524N5.1 PXT1 FHOD1 RPL23A GAS6-AS2 RNLSRP11-511H23.2 ZNF709 RP11-422P24.9 PSMB10 ZNF891 RP1-293L8.2 FBXO30RP11-15B24.5 TMEM8B HSPE1P2 BRD1 KLRC1 RAB9A NDUFA4L2 AD001527.4 BCL7AARID4A AC007228.9 ZFAND2B GRAMD4P8 ATF5 B3GALT6 RP3-406P24.5 RP11-73K9.3ENO1 GGCX UBXN6 RAB18 AC007773.2 HOXA-AS3 NELFCD RARRES1 ZMYM2RP11-456H18.2 C14orf80 AC078899.3 CACNA1I PLCG2 SIGLEC16 PIK3IP1-AS1NUDT7 DUOXI AP000295.9 HSPA14 ATG101 SYCP3 RPL15 ACTR6 NDUFB1 CCNF ZNF92RP11-298E9.7 EIF4A2P2 ZNF718 SYCP2 ITGA7 IMMP1L KCNQ1OT1 CRHR2 BRD2LINC00222 NCOR2 C1QTNF9B FOXP1-IT1 LINC00334 BST1 RP11-70C1.3 JADE1ERCC5 CTB-167B5.1 TBC1D3B MRPS17P1 RANBP1 CASP16P CTD-2378E12.1RP5-1115A15.1 UBE2N RP11-483I13.5 ACVR2A HCG11 ASPHD1 RP11-473C18.3FAM103A1 TAB1 FAM162A RGL3 MC1R RP11-104G3.2 ADORA3 JAKMIP3 RPL10A SKP1ZNF32-AS2 RPL36A CH507-9B2.2 RP11-333E13.2 AC016683.5 C21orf62 RPTORRP3-439F8.1 FNDC9 ATP11B CCDC91 KLF15 CLLU1 RP11-91K11.2 AC092573.2FAM73B ERBB2 RSRP1 C9 NGFR AC098826.5 CCDC92 CICP7 RP1-78O14.1 ZNF195TMSB4XP6 AC008746.12 RP11-613M10.6 LURAP1 SQRDL ECHDC3 CXCR4 TMEM8AURAHP SMIM10L2A RPL13AP7 FAM105A RP11-521L9.2 FAM196B NRXN2 SEPT7P2 TOX4ZNF189 ENTPD8 RP11-43D2.2 SEPT4-AS1 TMEM184A SMARCD1 YBEY PSMA1 PCDH1DDX6 RP1-140A9.1 FAT1 MSL1 RP11-15N24.4 RP11-92K15.3 USP54 MED6 TBC1D8BPDCL3P4 RP5-1068H6.6 WIPF1 RSPH1 FUT2 PLBD1 RP11-1415C14.4 ATRX TRPV3RIN1 C1QB DPH7 SERPINA5 C16orf87 CAST WASL PXMP2 RP11-147L13.15 CFHR1SETP3 PNKP AC012074.2 PPCS RCCD1 RPS5 NDUFA2 MEF2B CTC-281F24.1 DICER1UGT3A2 TMA7 NEK5 DLEU7 ABCA17P DAP3P2 RP11-848G14.5 SERPINC1 BYSL ZNF766RP11-138I1.3 RBP4 DEFB1 CTC-459F4.3 ZNF160 METTL15P1 INTS7 TRIM5 PITPNC1RP11-367N14.3 RP11-37N22.1 KRT8P33 ATP2A2 ANP32AP1 G6PC3 RP11-523O18.7AC114730.3 RP1-225E12.2 RP11-541M12.6 RP4-751H13.5 RP11-278A23.1C1QTNF3-AMACR SRSF6 RP11-157K17.5 ELF1 TYMS RP3-467L1.6 RP11-391L3.1RP11-849H4.2 CYB5A BRD7 LINC00959 PCED1A RP11-631N16.2 RP11-92K2.2DNAJC21 RP11-510M2.2 RP11-188D8.1 LEMD2 PEX6 LBX2 TTC9C ID2-AS1 FAM225ARP11-42I10.1 FNDC3A RP11-11N7.4 VN1R82P PPP1R8 TMEM223 PCDH12 PIK3CGRP11-38M8.1 TRIM27 RP11-148B6.1 CDK2AP2 RP11-195F19.29 SRSF1 ELP6SNRPGP4 RP11-817I4.1 FAM149B1 PGRMC1 WNK3 RP11-227D13.4 USPL1 HIST1H2BHAC012456.4 KCNK7 AC005481.5 RP11-445F6.2 SMIM13 RP11-264I13.2RP3-416J7.4 PCBD2 CTD-2270L9.2 RP11-687E1.2 RP3-508I15.10 GINS3RP11-554E23.2 F2 RP11-565F19.2 RP11-618G20.1 ITGBL1 LL0XNC01-250H12.3CTD-2561B21.7 RP11-223I10.1 RP11-15H20.2 CILP2 RP11-74C1.4 AP000343.2VN1R74P IFNL3P1 RP11-105C19.1 RP11-54G14.1 RP11-648K4.2 SPO11 FBXO17NLRP11 FAM171A2 RBSN RASA4DP AC000068.10 GLYATL2 RING1 AC005355.3RP11-27K13.3 EIF4HP1 ATP2B2 MATN1 EP400 C20orf27 C9orf129 LINC00896FKBP2 RPS19 CTNNBL1 PRDM12 WIPF3 IP011 HIF1AN AC004623.2 ABHD17AP1 HSF4CTD-3025N20.3 PACSIN3 ENG DDX27 HMGB1P24 CLIC4 ICE1 AK4 HCG17 AC108868.3ZNF626 SLC44A5 RP4-595K12.2 PRR29-AS1 ARHGDIB EYA3 ADAMTS20RP11-343C2.10 GAS2L2 ATP6V0A2 DUXAP8 TIMELESS RP11-299H22.6 PDE6B ULK3LDHC LINC00882 RP11-66D17.5 LIG3 RP11-379F4.4 CTD-2562J15.4 AC007036.6RP5-844F9.1 SUGT1P3 UBE2H ASH2L LPAR5 ALB SYT15 CHRNB4 AC105339.1 ZNF527MYH11 SEC24B RNF224 AL590763.5 CTB-31O20.8 OTUD5 RP11-295D4.5 C1orf21PHIP SREBF2 ITIH2 FAM53C SEC62-AS1 CTD-2015B23.2 VMAC RP1-140C12.2RP11-394B2.1 RP11-109E12.1 TEN1-CDK3 AC104534.3 FOXJ3 CTD-2310F14.1AC092881.1 RP11-96D1.6 CTB-133G6.1 SMARCAD1 RP11-44F21.3 AC005037.3RBPMS2P1 ATP11AUN USP48 LINC01543 ATP11C TRIM35 MTND6P5 LEFTY1RP11-715F3.2 RP11-230C9.4 HMGN1 PLAC9 RP11-80P20.3 TAS2R43 RAB10 DHRS9GRID2IP SUMO1 MAPK8IP1 RHOT2 LINC00476 RP11-31F15.2 SNRPEP2 GAPDHP65EIF4ENIF1 RP1-30M3.6 UPRT TGIF2P1 RP11-106M3.3 GGCT bP-2189O9.3 MANSC4SMURF2 RP11-512M8.11 ANXA5 RP11-354M20.3 NFASC FLU RP11-84D1.1 ZNF12SIAH2 RP11-142C4.5 CGNL1 PTOV1 CCNB2P1 BRD7P4 SEPP1 AP000640.2 AMZ1RP11-401P9.4 HIST1H4B EEF1A1P30 RNF207 CCR9 SETX RP11-462D18.2AC006539.3 AP4B1-AS1 RP11-22P6.2 AHCYP2 AP3D1 C3AR1 PSMA5 IFFO2 FMO1ATRIP CTHRC1 PPP2R3C EIF5A2P1 MSH2 RP1-159A19.3 MED16 AC096558.1 ORC1GALK2 SKIV2L2 FAM231A RP11-18B3.3 GSDMB CNTNAP3 BCL2L2-PABPN1 HDAC8PATL2 CTD-3065J16.9 IFT74-AS1 UGP2 SLC10A7 RDH10 HSP90AB1 PSMC1P1TNFRSF1B PPM1D FGF7 RP11-872D17.4 ZCCHC7 STAG3 CHP1 RP11-225H22.7RP11-572M11.4 RP13-1032I1.11 RP11-956A19.1 AC007283.5 RP11-223A3.1HOXC-AS2 CCT8L1P RP11-483I13.6 GAR1 BOLA2B RP11-305L7.7 BMS1P20RP11-996F15.5 RP11-488C13.1 RP4-555D20.1 DHX15 RP13-991F5.2 MRPL3P1GPR84 RP11-299P2.2 RPL7AP6 FAM132A RP11-284A20.2 P2RY4 LONRF2 RPL13P4KLK14 RP11-314N13.10 SLC11A1 NFKB1 CSDE1 RPL21P10 FHL2 AC007405.4FAM207A AGGF1P2 SLC5A12 CAP2P1 RP11-73E17.2 OSTC RP11-25D3.1 OTOARP11-146E23.2 NUP43 YTHDF1 ZNF252P DDX25 MFSD2B RP11-182J1.3 DNAH10OSRP11-352G9.1 AIM1L EFCAB6 DISP1 WRNIP1 EBF3 TOR1B RP1-122O8.7 TSR2AC239868.1 RP11-434I12.5 SNX18P13 IGHG3 ALAS2 RP11-605F14.2 SRGAP1TAS2R31 ZFP1 AC004490.1 LINC00598 NCBP2-AS2 RP11-317B17.4 RP11-79N23.1SUN3 AC093495.4 GABPA RP1-309F20.4 FAHD2A RHEBP1 CLUH SLC2A7 SF3B2RP11-454E5.4 RP4-705D16.3 RP11-647O20.1 LINC01297 NCAPG HSFX2CTD-2547L16.3 TPM3P6 RP11-49I4.3 AF224669.3 CFL1P1 AL109761.5 EIF4EBP2CTD-2621117.3 RP11-48B14.1 RP13-131K19.6 NACA2 HTR5BP TP53TG1_1CH17-13I23.3 RPL7P17 RP11-430C7.2 HSPH1 RP13-317D12.3 RP11-118E18.4 GEMCTD-2575K13.6 PRDX3P2 TET3 SMC1A FAM69A SMTNL1 DFFBP1 RPL7P4RP11-638I2.4 FUT3 RP11-693M3.1 RP11-215P8.2 TMEM168 RP11-244J10.1 TRGV5SH2B2 ARID3C ECHDC1 JAM2 RP11-466F5.6 TBC1D30 CRYM MLH3 CEP85 SIGLEC5CTC-436P18.1 CTC-559E9.6 SPATA45 VTA1 HEPHL1 HNRNPCP4 RP11-370I10.12DDIAS SNRPE CCM2 RP11-219B4.7 KIAA1211L AL133493.2 RP13-270P17.1B3GALNT2 RP11-74E22.3 STEAP3-AS1 RP11-567M16.3 RP11-273B20.1 RHOXF2BHIST1H2BM AC019172.2 CX3CR1 MED20 PDE6G RP11-310P5.1 SYNCRIPRP11-234B24.2 RP11-108P20.2 RP11-235E17.4 ING5 RP5-827C21.2 HNRNPA1P48MFSD6 RP11-345P4.6 RPS7P4 RP11-1102P22.3 RHOQP3 ICMT OPN1SWRP11-358B23.7 MAGOH2P RANBP9 PRSS8 RP11-1017G21.6 RP11-417N10.3 YY1P1SGSH GFOD2 BATF3 MORF4 UPF3AP2 CIAPIN1P EBLN3 RP11-157H4.1 RP11-474B12.1KRTAP5-7 ZNHIT6 SLC2A2 HIGD2B SAA2 RCC2 RP1-256G22.2 ERP29P1 MEGF9RP11-396C23.4 C1QBPP2 RP11-126F18.2 TRAM1 RP1-127B20.4 MED28P7RP11-217B1.2 ST6GAL1 LIMS1 PRELID1P3 ST8SIA5 ACTA2 MAP2K3 NIT2 INPP5KNTN5 OLFM5P AC005154.7 RP11-477I4.4 CTD-2047H16.3 SLC25A22 AC010980.2CAMTAI AP001429.1 LHX3 LINC01358 RANBP6 RP11-488L18.3 NDRG3 ARPC4-TTLL3PDPR C14orf2 RP11-220I1.5 CTD-2262B20.1 RP11-128A17.2 THOC7-AS1 SDR42E2ABCC8 TBK1 AC079753.4 MID1 DHX34 MTND4P9 BSN-AS2 RP3-467K16.4 RPS4XP6RP11-254F19.4 SRRT LINC01314 RP11-51J9.5 CECR5-AS1 P2RX4 ZC3H7ARP11-1348G14.1 C10orf55 KB-318B8.7 TRIM62 RP11-146F11.5 RP11-48G14.1RP11-392O18.2 RP11-102G14.1 MORN1 LL22NC03-22A12.9 GTF2IRD1P1RP11-506H20.2 RP11-372B4.3 RP11-365O16.6 METTL21B SREK1IP1 ACTR1BRP4-777L9.2 RP11-367N14.2 CSRP3 COMMD1 NDUFB11 C3 LINC01252 RP3-514P16.1EIF4BP2 HIF3A RP1L1 HNRNPA1P54 GAL3ST2 PIN4P1 ISY1-RAB43 RP11-849H4.4CNOT6LP1 RP11-51L5.5 RARRES2 RP13-383K5.4 AC009970.1 LINC01410 PNPLA6RP11-701H24.3 CTD-2623N2.11 HGF U91328.19 RP5-875O13.1 NCKAP5 BTN2A1CTD-2179L22.1 LINC01301 TRAF3IP2 RP5-1031D4.2 RPS15AP11 LAMA2 ZNF507HNRNPA1P61 ACTA1 SLFN12 BARD1 RPL32 GLOD4 RP11-104H15.8 IPO8P1 SETP22LL0XNC01-116E7.4 RHOT1 RP11-715J22.2 WDR45BP1 CTB-96E2.3 GOLGA6L3EIF5AP3 CTB-175E5.7 HNRNPA1P4 CTD-2308G16.1 MED24 SMG1P1 CTD-2002J20.1TMEM74 RP11-567C2.1 RP11-57G10.8 RP11-452L6.1 AC006145.4 LINC00652PIKFYVE LINC00641 TMEM97P1 RNF103 RP11-192H23.6 C15orf61 FOXL2NB EEF1DANGPTL5 SECISBP2 CNDP1 LCK F13A1 ZNF296 RP11-299G20.2 RP11-20B24.6 RND2RPS18 CTC-308K20.3 GAPDHP1 AP000925.2 DHX35 EFCAB9 COL12A1 ZNF833PRP5-1173I20.1 ZNF117 TCF12 AP000354.2 RP11-894J14.2 CFAP69CTD-2349P21.11 GPR173 NIPAL1 CTA-407F11.8 TEX12 CSF1R MRPS31P5 FEZ1C19orf35 RP11-791M20.1 AC020594.5 RP11-703I16.1 AKAP17A AKAP17ARP11-338E21.1 AL928742.12 CTA-972D3.2 RP11-643G16.3 WFDC2 DUSP22 CTSLLINC00239 RP1-121G13.3 EEF1E1P1 MYB-AS1 VTI1BP2 ANKRD20A17P GCNT7CTA-440B3.1 UTS2 RP1-182O16.2 RP11-37C7.3 ZNF354A RP11-597M12.2 HP09025CTC-510F12.2 RP4-736L20.3 MITF UBE2CP1 CTD-2583A14.11 RP11-58O9.2 CNTN2KLRC3 CNTROB NUP210 RP11-696L21.2 DLGAP1 CATSPER2P1 HMGA1P3RP11-303E16.9 PDXDC2P CDC20 DGCR11 DPP8 RP11-723O4.7 RP11-452G18.1RP11-425D17.1 RP11-62J1.3 FAM133B AC084809.2 VEZF1 SNAP25 RP1-5O6.4CAPN6 SNAPC4 SLC9A7P1 FAM167A-AS1 POT1 SYCE1L RP11-302B13.1 CDH26 HABP2ZNF646 AK3P3 RN7SL809P C15orf48 PPIAP22 TRBC1 RP11-430C7.5 CCNL2P1 CD200GOLGA1 FBXL20 RP11-713N11.4 RP11-119H12.4 SIDT1-AS1 RP11-148O21.4HNRNPUL2 RP11-572O6.1 RP11-350J20.9 RP11-2C24.3 RP11-252I14.1 ELP2RP11-263F14.3 RP11-2H3.7 PLB1 DGCR5 RP11-91A18.4 KIAA0368 PCNXL3HNRNPA1P66 THAP5P1 JARID2-AS1 AC016629.3 PLEC RP11-109E24.2 AP2A1 NXNVPS29 RP11-77M5.1 NME2P1 UBE2E1 GPKOW RP4-730K3.3 ZNF644 KRT18 GBGT1POLR1D BDNF EIF4EP2 FABP5P3 TRAPPC4 CTSC EIF2B1 RP11-162A12.2 RPLP0RP11-363J20.1 ACTG1 PRPF8 C9orf41-AS1 BASP1 TCEB3B RP4-761J14.9 MYO1ECTC-523E23.4 SNHG15 SARS FBXL12 RP11-1228E12.2 SLMAP PCDHGB6 SNHG9 GNG10RNF216 RP11-445P19.3 RP11-285F7.2 TARSL2 PDXP CICP5 ALG1 SS18 NUP107CTC-287O8.1 RP11-1060G2.2 TUBE1 CTC-435M10.12 CYP4F3 TH2LCRRRP11-460N20.7 TTLL7 KIAA0825 CTA-212D2.2 RP11-266K4.14 CTA-113A6.2ZBTB20 RP11-11M20.2 EIF2B5 KRTAP5-8 XRCC5 RP13-614K11.2 DBP AC005562.1ITPA CAPZA1 PEBP4 RP11-439A17.9 RN7SL219P ZNF691 NACC1 RP5-1000K24.2GNAT2 RP11-167N4.4 RP11-357N13.2 OVCH2 OLA1P3 RP11-346E8.1 IFT80ITPK1-AS1 CYP27A1 FAM92A1 RPS3P2 SGMS2 GRASP PLK4 COX7BP1 SHISA7 ATF4P4SPAG5-AS1 RFPL4AL1 RP11-1277A3.1 AC013264.2 RP11-116K4.1 RPEL1 RPS4XP3AL022578.1 BAMBI HNRNPF PTCD1 RP3-324O17.7 MAGI3 RP4-713B5.2 IGHV1-69RP11-9L18.2 LINC00487 RP11-173P15.10 COPB2 RP11-96C23.11 TMEM59LRP5-1074L1.1 RP11-277P12.10 TGFBR3 TLR8 CFI TIMM17B H1FNT RP11-557C18.3HNRNPA1P35 AC005624.2 AC124914.3 RP11-248M19.1 TAS2R10 RP11-734E19.1IGHV3-79 UGT2B7 ATP2B4 UQCRB RHCE CTC-338M12.5 RP11-553L6.5 EVI2ARP11-188C12.2 KCNE2 NUP214 PLAUR CHMP1B RP11-368I7.4 GS1-393G12.14 PLIN4HMGB1P10 RP6-109B7.4 RP11-524O24.2 PTOV1-AS2 KEL GTF2IP9 RP11-1277A3.3RP11-989E6.10 RP11-108F13.2 CCT6A C9orf91 SUPT16H DGKH MTA1 FBXL8BNIP3P39 AL591893.1 RP11-102M11.1 CCL2 RP3-510O8.4 DCUN1D3 RABGEF1RP11-680G24.6 XXbac- CRACR2B SUCLA2-AS1 BPG308K3.5 AC008132.13 RPSAP47HM13-IT1 RP11-89H19.2 CSNK1A1 RP11-142L4.2 FAM47E-STBD1 ZNF280D ID4MEAF6 SERPINA7 ACBD3 IRF8 HNRNPA1P2 IL1A SNORA53 ARHGAP15 DNAJC19P5 BMP3RP11-109P14.9 RP11-130F10.1 LENEP NDUFB8P2 GSG2 RP13-16H11.8 PLEKHA8P1PFDN1 RP3-337O18.9 ALOX12B ACTL7A RP11-413H22.3 AC073283.7 SLC7A2STIP1P3 PTAR1 NDUFB3 ARL13A TK2 NPHP3-AS1 RP11-289H16.1 INO80 TACR1C7orf73 FBXL13 FAM104A AK2P2 RP11-523H20.3 ANGPTL4 RN7SKP110 ATP6V1G1RP11-71H17.1 RP3-395C13.1 KIF5A SLC13A4 RP11-973D8.5 RNF183 AC002310.11CTD-2371O3.2 SNORD94 RP11-126K1.2 IGHV1-69-2 RP11-1012A1.7 LINC01364RP11-133N21.7 TAS2R3 RP1-90J20.8 YRDCP2 CTD-2252P21.1 STX1BRP11-544A12.8 BEND6 SERPINA1 RP11-55K22.2 RP11-67A1.4 PPP4C RP11-46A10.8ZNF253 PANDAR ENTPD4 BACH1-IT2 FMN1 PPFIBP1 VIPR1-AS1 RP11-178C3.6ADGRF3 RP11-272L14.2 AC139100.4 MRLN AC006486.9 RP11-501C14.7 DDX47 OSR2WI2-89031B12.1 UNC93B3 RP11-611O2.1 IGBP1-AS1 RP11-98G7.1 NTSR1 LPAR3JAZF1-AS1 LUCAT1 DYX1C1 MIR3180-4 FAM209A CTC-523E23.1 RP11-342K6.3RP11-229P13.23 PEAK1 RP11-709D24.6 ST3GAL5-AS1 ZNF733P AF131215.3RP11-415J8.7 TTLL12 UBE2D3P1 KIAA1429 ODF2 RP11-708J19.3 FTX_5 ISOC1DIMT1 MINOS1P2 EIF2AK1 AC007560.1 PPIL6 TMSB4XP8 SNORA41 SNORA17 SRD5A2RP11-981G7.1 AIRN AC011738.4 RP11-613M10.9 ZNF835 RPS26P52 RP11-95M15.2RP11-568G11.4 RP11-474D1.2 RCC2P6 GBA3 RP11-375O18.2 RP11-423E7.2RP11-536C10.10 ARL14EPL OR13I1P EIF5P1 GCC2-AS1 PGGT1BP1 LINC00824RP11-314A15.2 RP11-12G12.7 FCAR LINC01605 TMEM14B TTC17 HMGN1P4RP11-535C21.3 RANP8 UBE2E1-AS1 RP11-403I13.10 RN7SL55P CDC25A COPS8P2RPS8P10 RP11-983G14.3 RP11-173A6.2 THAP2 RP11-123M21.2 ZNF649-AS1RP11-582E3.6 AC004837.4 AMN RP11-298O21.7 RP3-403A15.1 RP11-454K7.1ATP6V1G1P4 CTD-3193O13.14 SDHCP4 RP11-15F12.3 AC079305.10 RP4-666F24.3NAA38 RN7SKP249 AC007292.4 RP11-521C20.3 CTA-280A3_B.2 IGLV5-37CTD-2265O21.7 RP4-764O22.1 SUB1P1 RP11-374M1.5 CTD-3193O13.13LOC100421166 IGLV4-3 RP11-1365D11.1 PARK2 RP11-167N4.5 RP1-34B20.4RP11-285A1.1 BCAN RP11-382A20.7 RNASEH1-AS1 FALEC TEAD4 AC073343.13RP11-393N4.2 CTD-2534I21.8 GALNT10 RP11-680H20.2 RP11-120B7.1RP11-290L1.2 RPSA RP11-292F9.1 RP11-367E12.4 KIAA1671 TEX35 CHI3L1RPL5P23 FRK NTN3 RP11-33E12.2 RP11-358B23.6 FAM117A RP11-329J18.5AC092651.1 EMP1 SRP54 HTATSF1P2 RP11-109E24.1 SNX14 KIAA2013 LLPHAC008280.3 AC091878.1 CAPZB AQP1 C6orf52 RP11-425A23.1 MESTIT1 MTND1P9LPXN FICD PAGE2B RAPGEF4 ASPN MORN2 BCL2 RP11-345I18.4 MRC2 ZNF335 REM1RP11-16C1.2 DRAXIN U51561.1 TMEM176B PFN1 CTD-2007H13.3 NUP210P1 BTBD1TNC MYRFL RP5-1024G6.7 TRPC4AP RP11-673E1.3 CCSAP ANKS3 EEF1B2 LINC01287SLPI AC024937.2 RPL21P4 RP11-367J11.3 XX-FW81066F1.2 RP11-545M17.3CTC-329D1.2 RP11-43N5.1 TMEM176A UFD1L RP11-186B7.7 HOPX RPSAP61 CHRNA7CDC42BPG SPRED2 COX17 RPS2P45 SARDH LINC00861 POLR2A MAMSTRRP11-1136G4.2 AMMECR1L AC005042.2 LMTK3 AC005307.1 IST1 GRID1 TMEM154SNORA73B AC016738.3 RP11-253I19.3 RP11-18H21.1 TMEM140 CTD-2410N18.5UBALD1 KIF18B ADAD2 DHX36 RP11-762H8.1 CDH24 KLF7 DCST1 AS3MTRP11-693J15.5 CCDC73 CNTLN RBM20 RP11-484L8.1 POLR1B LINC01555 NSFBTF3L4 RP11-530C5.2 TPT1P4 CTA-963H5.5 TMC3-AS1 CTD-2329C7.2 EEF1A1P4RP11-365H22.2 RP11-707G18.1 NPIPB3 CAMK2N1 SNRPCP3 RP11-731J8.2RP11-597D13.7 GS1-259H13.7 RP11-1017G21.4 NKAIN1 RP11-495P10.5 SNPHRP11-677O4.6 STAT5A LINC00909 PGM3 MICU1 RP1-20C7.6 HIST1H4FRP11-440D17.3 PPIF THAP9 RP11-764K9.1 NSUN5 TNFRSF12A BIN2 TRADD GRAMD2HIF1A-AS2 HNRNPA1P36 RPL18AP2 AC008074.3 RP5-867C24.1 RP11-83B20.1ARHGAP5-AS1 STARD6 AC109333.10 CHCHD7 RP11-455F5.4 NUTM2D AC011816.1FAM90A1 PABPC1P1 AC132217.4 CTD-2600O9.2 EYS HSD17B13 RP11-197N18.8SGF29 TMEM170A RP11-321F8.4 RP11-511H9.3 GRHL1 NEK1 MOAP1 RP11-522M21.3ANPEP DLEU7-AS1 COBLL1 RP4-791M13.3 NPAS3 HEYL SEMA6A EHHADH TMEM236DTNBP1 RP11-798G7.7 GOPC ZNF205 RN7SL211P KRTAP5-2 AP003068.9 RN7SL181PRP11-1100L3.7 AC012314.8 CTD-2528L19.3 SLC1A3 CDC7 RP11-15B17.1 PPP1R2P3RP11-265N6.2 PTX3 RP11-61L19.2 HYI-AS1 CLTA H19 SEPT14P12 RPS12P20FAM209B DMRT3 AL357140.1 CTB-12A17.2 ZNF83 MCM5 WDR5B SYVN1RP11-285E23.2 MRPS34 Sep-10 ENPP7P12 FGF18 HYDIN RP11-204M4.2RP11-315D16.2 SETP5 KLHL15 STX17-AS1 EFTUD1P1 TMEM45B BLM RP11-763B22.3ACTB RP1-274L7.4 ZNF549 SATB2-AS1 ERV3-1 SNRPB2 SPATA6 RPS12P31RP11-129K12.1 RP11-271C24.3 MN1 RP11-814H16.2 TRIM72 FAR2P2 AC100830.4ETFDH GK-AS1 C7orf49 PIK3C2B ADAM11 PYM1 CAV1 PHBP13 THOC6 DEF6 CCDC58P3OSBPL5 FMR1-AS1 CHTF18 RP11-23P13.4 PLAA SPATA6L LAS1L RP11-64B16.2ZNF720 CDH1 SETP20 PRDM8 RPL37P23 RP11-353K11.1 MCM8-AS1 CDH4 LYPLA1P3TGM4 AC006004.1 C11orf94 CLP1 RP11-130C19.3 RP5-1042K10.13 HCG4P3 TFCP2PDE1C YIPF3 R3HDM2 AC013470.6 RP11-193F5.4 SHISA4 RPL4P4 RP11-537I16.2ENAH DDX52 PIR FOXD4 RP11-45M22.4 CROCCP2 RPL21P116 RARRES3RP11-166N17.1 RP1-53O8.2 KRT8P50 LINC01342 EMP2 RP11-206F17.2GS1-393G12.12 ELMO3 CYP26C1 CTC-510F12.7 RP11-24C3.2 RBX1 MAP1LC3BRP11-666A8.8 CTD-2008P7.6 GTSF1 RAD51C STK33 DGCR9 ABHD14A-ACY1 AMZ2P2PDCD1 CTD-3214H19.4 CTD-2095E4.4 SLC17A5 OR6B2 FMR1NB ITPKB-AS1 GCLL21NC02-1C16.1 AC007238.1 RBBP4P4 RFTN2 HDAC6 NKX3-2 PRKCI FRAT2PCDHB13 RP11-406A9.2 ZZEF1 CSDAP1 SNRPD1 ISX RAB2A KLF3P1 AC097721.1DDX5 WBP11 CSNK1D RP11-402D21.2 RP4-639F20.1 ZC3H12C RP5-1031D4.3AC025918.2 RP11-80H5.9 RP3-412A9.17 AC004967.7 APOH LINC01444 CCNE1AP1B1 RP11-17M16.2 EDC3 RP11-305B6.1 CST3 ETF1P2 LL22NC03-23C6.12RP11-603J24.5 STXBP5-AS1 RP11-271M24.2 CXCR6 RP11-390B4.3 RP3-403A15.5LINC01298 ANAPC10P1 CTD-2292P10.4 MEPCE RP11-403P17.3 NCDN POLR2MRP11-778D9.4 ZNF480 NFE2L3 MED8 CKS2 EPS8 CTD-2192J16.11 TEX19AC007386.3 SMCHD1 RTN4R SLC4A1APP1 RP11-527H14.4 RP11-386G11.3RP11-630A13.4 AC017053.1 ANXA2P2 AC015688.3 SNRPF UPF3AP1 TMEM178AAF127936.3 CDCA4P4 ZNF75A COL3A1 MRPS16 PTENP1 RN7SL449P NIFKP6RP11-430L17.1 SMPD2 UTP3 RP11-686G8.2 CCDC42 ANKRD62 EEF1E1 WBP2NLCTD-2135J3.3 ZNF512B LANCL1-AS1 MT-RNR1 MPZL3 CENPQ OR1F12 VPS33A CYP4F2KCTD20 EIF4A1P4 TUBBP5 PPP4R2 ADH1C AC018737.3 uc_338 SLC25A3 PPIAP6SCARNA9 MEI1 RASSF2 AP000265.1 RP11-455J20.3 RPS15AP10 RP11-156L14.1RP11-432J22.2 PCSK1N TMEM169 ZKSCAN7 CDK1 LARS CH17-302M23.1 RSL24D1P6TTC21B RP11-91P24.7 TSKS HSD17B14 CTC-303L1.2 RPS19P1 COG3 RP11-597D13.9RP11-34P13.3 GAS2 NMRK1 PCBP2 PTPRS AC020915.2 MDS2 MAST4-AS1 PABPC1LINC00668 RPL12P8 PKN2 CTD-2514K5.4 RP11-195E2.1 DNMBP-AS1 CTB-179K24.3GUCY2C RP11-386I8.4 AC139103.1 AP006285.2 RP11-903H12.5 RAB4BCTB-35F21.1 WRAP53 LBP GOLGA7B RP3-330M21.5 MTF1 SUPT16HP1 CTD-2555A7.2COL17A1 UNC119 ARPC3P2 TAF5L CTD-2647L4.5 NODAL CTC-436P18.5 SLC2A3P1RPL34P18 BRK1 RP11-77H9.6 ESRRAP1 HHIP-AS1 RP11-2E11.5 MAEA TBC1D10CRPL23 WDR53 RN7SL316P ZNF526 JKAMP RP11-321F6.2 LUZP6 AC005682.6 SERINC5RP11-511P7.5 AC128709.4 MUC5B NAP1L1P2 RP11-525K10.3 RP11-977G19.14AHCYL1 EIF4B TOMM70A RP11-435O5.4 SUCLA2P1 ILF3-AS1 CTD-2256P15.4RP11-423F24.3 COX20P1 PHF13 RP11-840I19.5 AC009502.4 RPL35P2 ZNF37ASNX25P1 TMEM240 RNF169 DDX39B PDCD7 AC079117.1 RP5-837J1.4 BACH1-IT1AC113188.2 HIST1H3C AP3S2 ZNF586 EDAR OST4 CTD-2135J3.4 SMARCE1P6 FGD6ADTRP RP11-420K14.3 RPS7P7 SLC35F2 SIAH2-AS1 RP11-156E8.1 SLC36A1 TRIM29FAM107A LA16c-361A3.3 ASB9P1 RP11-1102P22.2 RP11-9E17.1 RP11-774O3.1ZNF814 CLCN3 ORM2 AC106782.20 CENPA ZNF267 TGFB1 KBTBD3 RP11-278A23.4XXbac- BPG116M5.17 ZSWIM1 FAM58A XPO7 RP4-751H13.7 GDA SAA2-SAA4LINC00648 MYL2 RP11-1197K16.2 RP3-355L5.5 FEN1 AC004980.9 RTN4RL2RP11-216N14.7 TFP1 FAM151B RP11-17G12.2 EIF5AP2 TMEM261 AC009302.2RP11-567M21.3 RPL4P5 HINT1 UGT1A6 RPL34-AS1 AJ003147.11 AAR2 ERI3-IT1CTD-2008E3.1 HSPA4L AC009487.6 RP11-286E11.2 U1 ANP32C RP11-890B15.2RP11-2C24.4 DDX12P SF3B5 CCDC88C OR11H7 DDX19A AIDA RP11-529H22.1 ZNF595COMMD2 AC005578.3 HNRNPUP1 FXR2 FGR C1QTNF9B-AS1 RP11-379F4.8 VIPAS39PHLDA2 ANLN XXbac- CXCL12 RP11-94C24.13 IGHGP RHBDL3 C8A BPG170G13.32TTTY10 CENPF PAX5 ANAPC10 RP11-97O12.7 CTD-2104P17.2 HOTAIRM1_2CTD-2517O10.6 ZNF106 LRRC75A-AS1 NOM1 CWC27 uc_338 RP11-3J10.7 ARR3 MELKTCEAL3 SKA2P1 COL6A3 RP11-6B6.3 RP3-508I15.21 MFSD7 AC144530.1 ADAP1GPR182 CTD-3222D19.8 SKP2 CTC-260E6.6 PIP4K2C AC012531.25 RPS6KA2-AS1PEX16 COL4A4 CTB-54O9.9 PRELID1P1 POTEKP RP1-197B17.3 ADCY10 TMEM160TRMT1 RP11-347C12.8 C3orf67 LEMD1 BEST2 ZNF202 SLC6A16 FBXL16 BAALC-AS1CDK19 CD14 ALDH1A2 RP3-417G15.1 TMPRSS5 BTF3P10 UNC45A ARHGEF7 Sep-03Telomerase-vert DACT3-AS1 AC000068.9 ARHGEF9 RP11-43F13.3 SPATA1 IFNA21IGKV1D-43 CRACR2A BNIP3P22 SPRY1 HP1BP3 RP13-467H17.1 PPP1R27 UBA3 TSC1RP11-1069G10.1 DIRC3 VAMP2 RP11-196G18.3 RP11-330M2.4 ALDH1L1 PRKRALINC01037 RP11-10J21.4 AC018890.6 ZNF721 EIF2A WDSUB1 RP11-461L13.5FAM60A ZSCAN22 FAM207BP GS1-25M2.1 DUSP5P1 DENND2A RP11-343B5.1 PHLDB2B2M HNRNPA1P10 RP11-65N13.8 PTPRR SNORA52 HSPA8P9 RP11-402J6.1 MYL4AC009228.1 MYL6B HOTAIRM1_5 NKIRAS1 BHMT MIIP RP1-29C18.10 RP11-421L21.2DAGLA YPEL4 AP000253.1 CTD-2062A1.2 TSHR RAB28P5 CCDC151 PLXNB1 PKMP1RP11-18I14.11 TANC2 LOH12CR2 FZD1 RP4-669P10.20 RP11-972P1.7 AC114776.1MRPL51 MAN2B2 NSMCE2 MRGPRG-AS1 NAT1 RP11-2H3.6 ZNF669 SLC35E2B CNPY1COL4A3 CTD-2007L18.5 RP11-44N11.3 PNN FBXW2 RPL31P11 TARBP2 FFAR1RP11-266K4.9 SH3GL1P3 RN7SL78P ZNF365 CCDC152 LA16c-390H2.1 STRIP1 KCTD4SRPK2 RP11-197N18.2 SHROOM1 USP50 SCNN1A IPO7 RPL7AP25 MME-AS1 TRIM56ENGASE KHSRP KB-1615E4.3 RP3-337H4.10 UQCRC2 ATOH8 CCDC121 HLA-DPA1FAM60BP HPS4 RP11-409C19.2 APBA1 MZT2A FAM166A NPM1P21 TNFSF12RP11-474P2.6 NEK2 DLEU2_1 ROBO3 LVCAT1 RP11-466A19.1 WDR91 KDM6B UPF3BRP11-56D16.8 LRRC75A RP4-798P15.3 KRT18P37 NPIPA7 RP5-1086K13.1 FAM78BCFAP52 RP11-34P13.7 RP11-537H15.4 LCMT1 Sep-02 IGLJ2 PPEF2 NEUROD4MAMDC2-AS1 IGF2 RP11-424M24.5 RP11-227B21.2 MKNK1 ASS1 RP11-677M14.5SERBP1P6 BFSP1 RP5-837I24.1 FGF14 CTC-428G20.6 CHRD HMGN1P37 ETV5AC025442.3 RP11-27I1.4 PAPPA C1RL-AS1 LARP4P AP000302.58 HIST1H2ALALG1L13P GXYLT1P4 CWC15 RP3-369A17.6 NANOGNBP3 Sep-04 CHRND AP001059.7ZNF382 KLHL14 SPP1 SLC35E1P1 CEP89 ADSSL1 ZNF234 RP11-187C18.4 PVRL4TRIM54 ADGRB1 ZNF180 RP11-274B21.10 RP11-573D15.3 MTUS2 C21orf91-OT1HES7 MARK2P4 CPNE6 RP11-446H18.6 LINC00659 AC015969.3 CLU SNAI2 PHF20L1RP11-848P1.4 AC016629.7 MAP1LC3B2 ZNF30 RP11-227G15.2 CD81-AS1 ZC3H15CTAGE3P SLC22A7 DCT METTL17 CEP250 CLEC18A CHTF8 TPR NFX1 ZWINT FAM134BRP11-339B21.13 CNPY3 RP11-294N21.3 CCDC154 RP11-631M21.7 ATN1 DYNLT1 OSMLAMB2 RP11-60A14.1 C3P1 FTH1P5 RNFT2 BMS1P16 RP11-44N22.3 GPC4 RBMS2LL22NC03-80A10.6 RP11-229P13.25 NR4A2 AC007383.4 RP5-944M2.3 NTRK1 TBX1RPL7P14 EIF4A2 ASGR2 EXOC4 RP11-477J21.2 SLC47A1 RELL2 HLF RP11-53B2.4TBCA OR13E1P CBLB RP11-1136G11.8 RP11-128N14.5 CECR6 RP11-732A19.5AP001631.10 CH507-152C13.6 ABC12-49244600F4.4 Metazoa_SRP PRPH ERH GAREMH3F3AP6 RP11-382D8.3 HMGCS2 DNMT3L RP11-47A8.5 DBH-AS1 RP11-618K13.2PCTP RP11-823E8.3 GNG13 RP11-90M2.5 RP3-441A12.1 GPS2P2 USP13 TCEA1AC023128.1 KB-1027C11.4 LARP7 KCNMB2-AS1 RP11-227G15.11 GTF2A1 GTF2BPAX8 PMS2 MYO1F CCNDBP1 ZBED4 SLC7A11 EIF3G CD248 ZRSR2 CHCHD2 KRT8P39DLG3 EIF4A1P2 PFN4 RBM4 DZIP3 NCLN IGLV2-23 CTB-43P18.1 ADAM20 EXOC6RP11-136K7.2 RP11-290D2.3 UGT1A7 BGN C20orf144 RP11-22B10.3 BPNT1PPP1R11 DLG1-AS1 TMEM150C APEX1 SRSF5 PSMD3 NRG2 ATF1 RP11-689P11.2CNGA4 PGM5-AS1 MT-RNR2 MEP1B AC108004.3 CTD-2081C10.1 EOGT FA2HAC003006.7 AC110781.3 RP13-46H24.1 RASGEF1A RPS25 CCT5 RP11-57H12.5RP11-219G17.8 RP11-153M7.3 CXCL8 AC069368.3 C17orf78 PSMD10 U1RP11-661A12.7 U1 BTBD8 KLHL18 STK4 NECAP2 CTAG2 MR1 CCNO CTC-242N15.1TONSL-AS1 C10orf91 LRRN2 CDHR2 OR6L1P RP11-160N1.10 RP11-156E6.1 ZG16BSLC39A9 UTP15 CTD-2199O4.3 FAM83E GALNT15 CUL2 RP11-395I6.2 TMEM17RNF208 BCAM PLEKHA7 CTD-2O35E11.5 UBA1 RP11-136K14.2 EPPK1 TNFRSF8 AIRECXorf58 CREG1 LA16c-60D12.2 CTD-2083E4.6 PLA2G12AP1 RPS2P4 PPP1R3BFAM83G CTC-459F4.1 ADH4 NAT10 RP11-30L15.4 FKBP10 MZB1 TIMP2 STX7 SMAP2SLC22A1 HIST1H2AD TMEM165 CIR1 BHLHA15 LINC01398 DCAF7 GEMIN2 PPP1R14BDPYS TSSC2 AC099535.4 POLR3E RP11-565J7.1 PIGB AHNAK BUB1B B3GNT5 ZNF429AP000350.5 C14orf166 SMIM3 BAGE2 XRN1 ITFG1-AS1 SNORD10 KDELC2 PPY2PAC017104.3 AC005754.7 AC009963.3 IWS1 AC217773.1 ZNF221 RNU1-106P FTX4RPL39P34 TCL6_3 RP11-318C24.1 SURF2 TLL1 UQCRHL HIF1AP1 RP11-98F14.11uc_338 ITIH3 CACUL1 LACTB2-AS1 RP4-635E18.6 IGLV3-24 RP11-284A20.1CH507-42P11.2 KIAA1522 RP3-406P24.3 SNORD91A LIPH RP11-885B4.1RP13-225O21.2 RP11-571I18.2 RP11-1250I15.1 MTCO2P2 RP11-262M14.2RP11-739N20.3 RP11-1212A22.1 RP4-758J24.4 RP11-589N15.2 SNORA70 Y_RNASNORA10 SNORA5A SNORA14B SNORA40 SNORA24 EXOC3L2 FARSA-AS1 GIMAP1 IRS2PCDH19 AF127936.9 DSG3 RP11-454H19.2 MRC1 RP13-147D17.3 RP11-218E20.3PCDH10 SCN7A ANKS4B TNN PIEZO2 MPDZ RP11-471M2.3 MBL2 PCDHB3 CNNM1 LPAGRK7 ANKRD35 DUSP27 RP11-416I2.1 RP11-1099M24.9 RP11-728K20.2 ABCG2AC005014.5 SNX19P3 CYP7A1 RP5-1186N24.3 CDCP1 P2RY13 CCR1 AC092198.1TNPO1P2 AGBL1 PTPN5 MAPK4 RP11-555J4.4 RP11-976B16.1 RP11-805F19.3RP11-30P6.6 TEDDM1 SLC26A8 RP11-641A6.5 AL360294.1 RPS21P4 UBE3AP2SACS-AS1 RP3-326I13.1 RTP1 ERVV-1 AC104024.1 RP11-1036E20.7 RP11-497D6.5KCNIP3 MRE11B GAS7 RP1-167G20.1 RP13-870H17.3 AC018742.1 NTN4RP11-525E9.1 ZNF33AP1 NKAIN2 AC121251.1 CTTNBP2 LINC00052 FUT5 TDRD9AC009313.2 FIBIN TSLP SULF1 CECR3 GFRAL RP11-325E14.2 CTNNA2 RP1-28C20.1RP3-347M6.2 CTD-2383M3.1 SLC17A8 ENTHD1 MMP2 CAP2 VSIG8 MTND5P6 ZNF501APOBEC4 NPTX2 SNRPFP1 RP11-367H5.8 CYP2G1P CTD-2587H24.5 CCT5P1 LHFPL3PGLYRP2 FAM149B1P1 PRKACG CCT6P2 MATN3 LL22NC03-84E4.8 CTB-113P19.4RP1-269M15.3 RP11-8H2.1 SPTSSB RP11-405A12.1 bP-21201H5.2 NMD3P1C11orf96 REG4 KCNG2 TCAM1P RGSL1 EEF1A1P7 TUBB8 RP11-494M8.4RP11-513D5.5 MKRN9P FNDC4 FKBP4P1 UCA1 HSPB2 PSMC1P4 C2orf27B GNAI1RP11-403B2.10 RP11-334E6.2 FEV KRT18P23 KRT8P26 ZSCAN5B TMPOP1RP11-249L21.4 AP000688.14 ODF3L2 TARDBPP2 RP11-157G21.2 IGFL4 TMEM119FRMD6 EIF4A2P4 LINC00525 POU4F3 RP11-157F20.3 C1QC HNRNPA1P23 ART1ACTBP7 CHODL-AS1 ST13P2 AF131216.5 PTCD2P2 ACTG1P16 OR2AE1 USP12PXRP5-1039K5.16 OR10A5 KRT18P33 GTF3AP2 PGGT1BP2 LDHAP3 KRTAP9-2 PABPN1LGYG1P3 FAM170B-AS1 KRTAP9-3 SPDYC DMRTC1B IFNA5 OR7E28P RP5-907D15.4CT45A3 HOMER2P1 RP11-144G7.2 RP11-1079K10.4 NAT8 NCR1 SLC25A38P1CTD-2199O4.1 OR10AB1P MIR4500HG RP11-1260E13.3 KRTAP5-10 SLC25A5P5CLDN10-AS1 RP11-332G1.1 RP11-286N22.16 SDCBPP1 RPL5P3 OR7E31PRP11-152F13.10 RPL5P17 RP11-415I12.3 C19orf45 MRGPRG CDA RP11-466C23.5AC009506.2 AC068196.1 RP11-18F14.4 MIR99AHG RN7SL812P RP11-1112J20.2RP5-1039K5.17 PPIEL AP000318.2 RP11-141P6.1 AC084149.1 RPS4XP13LINC00629 RPS4XP7 RP5-903G2.2 CTD-2008P7.3 PDZK1IP1 RN7SL787PRP11-344B2.2 FRG1EP RHOXF1 AC084193.1 RP11-287D1.4 AC073869.1 AC012493.1LINC01326 NCAPGP2 SNRK-AS1 RP11-350E12.5 RP4-816N1.7 RP11-20I23.7SNX18P26 MTND4LP14 RP11-799B12.4 HNRNPABP1 TPM3P7 SLC8A1-AS1 RN7SL753PRP11-798K23.5 PGAM4P2 RP1-230L10.1 RP11-73M7.6 RP11-440L14.3RP11-603B24.2 AC009784.3 VTI1BP1 GYG1P1 RP11-354P11.4 CTD-3157E16.2RP11-436D10.3 RP11-77K12.1 XXbac- BPG252P9.10 RP11-485M7.3 TRPC4 ARMC4P1LYPLA2P2 RN7SL513P RP11-553K23.2 Metazoa_SRP RN7SL411P RP11-151G12.2AC008427.2 RN7SKP130 DPYD-AS1 CTD-2196E14.8 RP11-518L10.5 RP4-655L22.4RP11-74E22.6 RP11-3J1.1 ERVH-1 VTI1BP3 C17orf98 RP11-516C1.1 ZNF197-AS1RP11-114F3.2 RPS5P3 RP11-100N21.1 RASA2-IT1 RP11-564A8.4 CTD-2086L14.1RPS3P6 NPM1P32 RP11-477G18.2 CYCSP11 SUB1P3 CTD-2288O8.1 TLE1P1AC113607.3 RP11-662B19.1 RP1-292L20.2 TCEB1P28 RP11-573G6.9 RPS9P1AC006116.24 CCL19 BNIP3P19 CTD-2256P15.3 RP11-77K12.4 RP11-697H9.3CHCHD2P2 RP11-708L7.6 RP11-263K19.6 RP11-698F20.3 RPL9P33 RP11-383C5.8RP11-177J6.1 AJ239321.3 RP11-455P21.3 RN7SL154P CTB-50E14.4RP11-566K11.7 RP11-490E15.2 RP11-930O11.3 RP11-108B14.4 RP11-394B2.6POLR2G RP11-474B16.1 RP11-413H22.2 RP3-472M2.2 LINC00400 RNF138P1RP11-526K21.2 PTMAP3 RP11-770J1.3 CTC-435M10.10 RN7SKP203 RP11-365D23.4RP11-13N13.5 RP11-60I3.4 RP11-543G18.1 CTD-2568P8.1 FAM184A ARF4P4RP11-15A1.2 AC005593.2 TPT1P6 Metazoa_SRP RP11-15I11.3 RP11-295M3.2RP4-680D5.8 AC093106.5 AC108463.2 PIGUP1 AC111200.7 LLNLR-259H9.1DAZAP2P1 RPS26P15 RPS26P31 H2AFB2 IGKV1-33 RPL12P30 RP11-451N19.3RP11-568J23.4 RP5-1092A11.2 RP13-820C6.2 RSL24D1P1 RP11-774O3.2PLCXD2-AS1 RP1-4G17.5 IMMP1LP1 RP11-719K4.3 RP11-996F15.4 RP11-3K24.1RP11-90E9.1 RP11-73M7.9 RP11-181K3.4 RP5-1029F21.4 OR7E62P CTD-2529P6.4CTD-3065B20.2 RP11-342M21.2 AC005757.6 RP11-54O7.11 CTD-2182N23.1IGLV10-54 ARHGAP22-IT1 RPL23AP18 RPL10P3 RP5-1115A15.2 CTC-209L16.1GS1-69O6.1 RP11-665C16.8 RPL34P31 RP11-363I22.3 CH507-39O4.2RP11-259O18.5 RPL31P63 IGKV1D-39 RPL23AP88 RP11-595B24.2 H2AFZP4RP11-625L16.3 RP4-771M4.3 MAGOH3P AC090952.5 RP11-54O7.2 RP11-74C13.4RP11-493L12.7 RP1-41C23.4 RP5-1087E8.3 CTD-2566J3.2 RP11-807G9.2RP11-517O13.1 CTC-498J12.1 C1orf189 RP11-148O21.3 RP11-253M7.4 NUCB1-AS1RP11-571M6.18 CTD-3105H18.9 RP11-3L10.3 RP11-791G15.2 RP11-350D23.4RP1-102G20.2 RP11-666A20.4 RP11-188P17.2 RP11-344P13.1 RP11-713D19.1RP11-313P22.1 AC093159.1 RP11-532F6.4 RP11-154D3.1 CTD-2527I21.9RP11-483M24.2 RP11-244B22.7 RP11-230F18.6 RP11-312B8.1 RP4-585I14.3RP11-474G23.2 PNPLA5 RP5-836J3.1 CTD-3193K9.3 AC005616.1 RP11-697E2.12PRUNE2 CC2D1B NDUFAF5 BHLHE23 GTPBP6 GTPBP6 POLR2D SMYD2 MMP1 NR2F1MPPED1 F7 TBC1D22B RP11-307C19.2 KCNJ2-AS1 ALS2CL RP11-247L20.4 DIO2RP11-359E7.3 RP4-555D20.4 RP11-1100L3.8 RP11-158I9.8 RP11-366M4.1 COQ7CTC-428G20.1 ABLIM3 PLA2G5 GCNT3 INE2 LINC00846 RPSAP6 ARHGEF5RP11-463O9.2 RN7SL328P GOLGA8F C19orf33 RP11-876N24.3 RP4-633O19_A.1RP13-349O20.2 FCN3 RP11-745L13.2 DNMT3B RN7SKP163 CCDC173 ATP9ARP11-10O17.3 ATOX1 AC139099.6 NEMF RP11-756P10.3 LRRC41 PLEKHG3 CPSF4CCNB1IP1 KCNH7 AKR1C4 RP11-259G18.3 RP11-203M5.7 NIF3L1 AC078883.3RP11-363E6.3 RP11-21L23.3 ENOPH1 RBPJ DXO MADCAM1 MIAT_exon5_1 NDUFC1RN7SL748P SCML1 PUM1 BRD7P2 TSSK6 CHCHD10 MNX1 KRT8P27 BTG2 C3orf49RP11-302M6.5 NUDT13 CHRNA10 ANKIB1 RP11-548P2.2 RP11-356K23.1 GLYCTK-AS1CTD-2396E7.9 FAM57B CDH2 RPL3L TBCEL GNAI3 KIFC3 CCDC65 OGFOD1 CSF3TP53BP1 LINC00173 PRICKLE4 DCN SAP18 PROX1-AS1 CWF19L1 TMEM102 FLCNRP11-252E2.1 LINC00578 HMGB1P16 JPX MYO15B KIAA0100 CCDC144NL BNIP3P16RP11-371A19.2 NLGN2 EEF1A1P6 ZNF671 NOX1 LRRC37A5P OR1M1 CCDC126 UTP14CXXYLT1-AS2 RALGAPB THSD7A RP11-3P22.2 GRID2 DPP9-AS1 SHC1P2 C1QTNF5ARL6IP6 AGPS BMS1P4 SNORA23 RP11-33N14.5 AC008937.3 RP11-622C24.2 OSMRRP11-568J23.8 HIST1H2AM ZNF7 PKHD1L1 LIN37 BCYRN1 AC009120.4 SLC35B4ARF4-AS1 SENP1 RP5-890E16.2 GPS2 MTOR RP11-49I11.1 RBM4B RP4-806M20.3SDE2 RN7SL731P PON3 MRPL48 CTA-25406.1 RGAG1 TSPYL2 HMGB1P3 LSM12TMEM232 AC090587.5 BCOR C4BPB FKBP4 ERP27 CPN1 CTD-2369P2.4 S100A11P1AC016738.4 ZNF542P CASR KRT6B HLA-DRB5 FDX1 DNA2 HAPLN4 RN7SKP176CTD-2287O16.4 RP11-684B2.3 Metazoa_SRP FOXP4-AS1 MYL5 PFKFB3 WNT10BCHRNA3 HSPA8P1 UTS2R ABCA3 NAE1 MAML1 COMMD9 AMACR RP11-766H1.1RP13-539F13.2 GNG12 FANCD2 RP11-266L9.8 SNTG2 CH507-154B10.1RP4-693M11.3 HULC RPL13P12 CTC-429P9.4 EIF3E RP5-1021I20.5 CTA-204B4.2SERBP1P1 SPRR1B ATG2B UGGT1 TUBA4B CCNI2 COX8A RP11-359G22.2 NFIXRP11-708J19.1 IL17RE ASNSD1 RP11-63M22.2 ANP32B RP11-434H6.7 SEC23BFMNL2 JMJD4 C1orf115 LINC01170 HSPB9 IFNAR2 RP11-701H24.9 JOSD1 GGNBP1DLGAP3 THBS4 LONRF3 FUZ bP-21201H5.1 HPCA RP11-7F17.8 AP000254.8 BCL2L12FAM21EP ABCC6 HIST1H4A DUSP18 TJAP1 SPAG6 RP11-486L19.2 ACVR1CRP11-90K6.1 CHD8 DNAJA1 ARID3A PRPF38A TRAT1 CTB-63M22.1 TGFBI APOA5CSNK2A2 SLCO2B1 VCAN YME1L1 AC011899.9 RP11-388M20.6 TRAPPC3L LINC01465RPF1 ZNF14 TCF24 CITED1 ANAPC15 FGF2 HNRNPU PUM2 FLT4 BDP1 EXOC7 PARP4P1UGT2B10 STPG2 DOK2 CHMP1B2P RNH1 RP11-872J21.5 FAM160A1 IRF1 TBX2RAD51AP1 CTD-2302E22.4 PDCL3 HRG OSBPL11 RPS15 AP4E1 RP11-366L5.1 HAP1CPB2 INS-IGF2 STK38 NR2C2AP COL6A1 AC003002.6 NF2 PCP2 CDKL2 CCND3RP11-693J15.4 ZBTB49 CTRC SLFN11 RP11-9M16.2 RP11-102L12.2 UNC13A ZNF410LINGO3 TDP2 CADM4 ERCC6-PGBD3 AC009961.3 PZP ATP6V1F UXT DTX2P1-UPK3BP1-PIGR FLYWCH2 HTRA1 PMS2P11 PPP2R5B BTNL8 RAB30 INTS6 ZNF91 ADCK3SNORD3B-2 LCN2 CTD-3128G10.6 C9orf16 SMARCD2 TAF4B WHAMMP3 EIF4G3 USP31CDH12 RIMKLB PPP4R3B LINC00963 GAPDHS HSPA8P15 RP11-327F22.4 USO1KANSL1-AS1 EIF4A1 MAP3K10 AURKAPS1 TCEA1P2 ANKFN1 RP11-203J24.8 MRFAP1STAB1 AFP RP11-429J17.2 YWHAG ZC3H14 NCBP1 SPATA24 RP11-115J16.2 SDF4AC004980.10 MASP1 TFF3 GPX2 PRIM2 SIX1 OAZ2 CCDC180 RP11-529E10.6 SGSM2RP11-269F19.2 EZH1 LINC00634 JADE2 SLIT3 USP8 GPN2 TMEM42 ADAMTS17 ANXA1SLC46A2 BACH1-AS1 TMEM134 RP11-69M1.6 RPL5 DCAF16 YWHAB PCBP1 FBXO38C1orf100 MIP bP-2189O9.2 TEX38 POLD2 ZNF548 RGN GARS RPS16 NOL12MORC2-AS1 METAP2 STK11 RP11-316M1.12 RP11-47I22.2 TCN1 LSM5 AAMDCTNFSF14 RP3-475N16.1 DEK ECI1 ZNF154 MED30 MCM8 ZNF251 C9orf172 CUTASECISBP2L KB-1460A1.5 HMGA2 TLDC2 RP5-997D16.2 TRAF3IP1 C1orf52 CACNA1FRPSAP9 NPIPA2 ETNPPL SYNJ1 RP11-74E24.2 CTB-113P19.5 HAUS8 PSMC5 CIARTTRIM60P14 IGHV5-78 DAZAP2 MPC1 RP11-643G16.4 AP1M2 RP11-338K17.10FAM153A ZCCHC9 GNA13 STK17B TDO2 KLHL9 NADSYN1 ARL5C CYP2C9 LGALS9CCTBP2 CASC11 SPAST SPDL1 PIGA AMOTL1 ZNF292 COX7A1 MPV17 CLIP2 YY2 ADCK5C6orf25 AC093901.1 PCNA SLC25A46 ADAMTS7P1 SNX13 ADGRA3 TCTE3AC017116.11 RP11-20I23.2 PLEKHB1 RPL38 PSMA4 KBTBD8 LINC01344RP11-290L1.4 YARS OGT IL9R IL9R SRP9 XAB2 PLEKHJ1 CTD-2547L24.3 ECT2ELOVL3 HBP1 RP1-257I20.14 TBC1D14 RSPH10B2 CLNS1A MICB MTMR9 IL13RA1PAXIP1 C6 SRFBP1 EAPP UTP23 MTO1 RP11-521B24.5 SH2D6 SLC2A10 CNTD2RP11-646I6.5 RP5-1057120.4 SMURF1 MAGEA2B F9 ZNF326 PAICS RNA5-8S5RNA5-8S5 RNA5-8S5 RNA5-8S5 RNA5-8S5 RNA5-8S5 RNA5-8S5 RNA5-8S5 C16orf59SMPD4 GAREML CETN3 IGF2R ADAMTS1 CROCCP3 TM2D3 LRRC16B MT1E RRAGC MBTPS1SMG1P7 RN7SL4P RP11-160C18.2 SBNO1 HSPA13 SYNJ2 CTC-458I2.2 CD70 PRB2NENF AGAP4 ADD2 UQCR11 ARIH1 ELMO1 DNAJC9-AS1 ATP6V1B2 EPHA2 PRDM1MARVELD1 HP C4orf27 RP11-148K1.12 LINC01447 ZNF684 GNL2 COX7B SSB IDH1RAP2B TMEM41A CYFIP1 HNRNPLP2 SCAP ADH1B CLEC18C PPP1R13L RSU1 KRT6AADAM17 GTSE1-AS1 ADAT3 RNF185 RP11-478J18.2 SNRPC AC006011.4 BORCS6RP11-320N21.2 APLP2 NCAPH2 LINC00899 CTD-2201E18.3 EXOSC3 ELAVL1 UPF2LINC01249 RP11-2E11.6 B3GALT5 ADCY10P1 ZC3H11A SMIM2-AS1 NIPBL PARP6MKNK2 AC107081.5 KMT2C TTF1 DKC1 PUF60 PTGES2 N4BP2 RP11-333E13.4 ARSDZNF263 SHARPIN FAR2 MAP1B SLC7A11-AS1 DDX1 REV3L TMEM187 SSU72 NYX TTBK2FAIM2 FAM66C ITGA5 COX6B2 LINC01624 RP4-728D4.2 RP11-443B7.1CTD-2540F13.2 RP11-15L13.4 ATPAF2 RP11-87H9.4 CTD-3064H18.4 GGNBP2EIF2S3L GTPBP2 SPEG EPG5 GPHN FGF14-AS2 COPS3 CCDC94 TCP1 HERC2P9 DCPSTRABD2A GPR22 SETD2 JAGN1 PRDM4 RP11-135F9.4 OXSR1 SRSF7 DCST2 SERP1QSER1 PLEKHH3 C18orf54 GCC2 CNTRL COL4A2 TNNI3 NME2 ZC3H18 SNRNP70RP11-134L10.1 MRPL36 KNSTRN COLGALT1 PSD4 SAMD9 SLC10A3 CNN2 ADCY5GS1-57L11.1 COX15 RP11-113D6.10 FOSB ACD AC074212.6 CHMP3 PON1 WDR74WDR3 TMEM132B ACSL6 POLR2K AC010761.8 ARL17B IGKC BRWD1-AS2 VPS16 CEP78GABRE MCF2 TLR10 TRAPPC12 CCRL2 STAU1 TMEM125 C2orf69 RP11-496H1.2 TSFMSERPINA9 RP11-508N22.12 SNRPD2 SLC26A4-AS1 RP4-548D19.3 SGTBRP3-477O4.14 SBK1 CEP164P1 ZNF606 ASTE1 ESR1 EIF3J EPN1 TFPI HBS1LHIST1H2AE CERS5 B3GNT9 AC006077.3 ATRIP ST7-OT4 TICAM1 DPY19L2 BMS1P1DDX17 PIN1 ARMT1 NARS2 RPP21 DDX31 NRROS CFTR MYH16 HS3ST1 AOC1 HECW1KLHL13 CYP26B1 HSPB6 PDK4 SLC4A1 PRSS22 ITGA2B ASB4 TMEM98 CX3CL1 ETV1SCIN PROM1 NOS2 DNAH9 MATK TKTL1 SELE FMO3 SYN1 CRY1 PGLYRP1 MLXIPL ETV7SLC6A13 PRSS3 ANOS1 NR1H4 SLC7A14 MAMLD1 DPEP1 NPC1L1 STMN4 IL20RA CLCA4IGF1 VSIG2 MARCO CYP24A1 ADGRA2 SLC7A9 NRXN3 EHD2 INSRR APBA2 EFCAB1 OTCSLC18A1 HOXC8 RAI14 SOX30 RAB27B MYO16 FAM65C USH2A PREX2 ANO2 CC2D2ALMO3 KITLG TNFRSF9 EPN3 COL23A1 FSTL4 METTL24 KCNQ1 ENTPD2 CHRDL2 DCBLD2SERPINB3 TMCC3 TBXAS1 GNA15 CREB3L3 RIMBP2 LZTS1 PRDM6 WNT8A CDH3 LIMCH1TSPAN32 WISP2 ST3GAL6 POU1F1 ROPN1 TLE2 ME1 TIE1 SLC9A3 NGEF MPPED2FGFR2 EML1 PHKA1 PDZD4 ATP2B3 INPP5A STON1-GTF2A1L ADGRF5 MAOB DRD4 HES2PTPN3 ST6GALNAC1 CNGB1 CHAT CAMK2A MS4A12 LMCD1 CDH19 SPP2 RHOBTB1 PVRCYP2W1 PTGS2 PPP2R2C CA12 NUAK1 ARHGEF10L KCNQ2 SEMA3C CACNG5 CACNG4PLD1 ATP12A PAX2 RGS11 PLXNA2 ACTL6B PAK3 DCX ACTN2 FKBP6 CST7 AMPH FAPHOXA9 FGF20 BRINP1 CDH17 OSBPL6 DUSP13 DDX43 SCTR COL5A3 KCNN2 CXCL2CACNA1S PKP1 LRP2 SLC13A1 CADPS2 PCDHB4 PCDHA6 MPP4 PGR OPRK1 SEMA5BTRPM3 GRHL2 SLCO1A2 COL16A1 GCKR MECOM IGSF9 WNT11 FOLH1 EPDR1 HSD17B2ACHE TMPRSS11E CETP MT3 LPCAT2 TFAP2C SULT2B1 SLC15A1 TMEM40 ARHGAP28SMOX SIGLEC1 C20orf194 CPXM1 F11 CFAP61 RPH3A NOS1 HEPH FETUB CD209NRCAM SLC26A3 IL5RA CMA1 DAZL FMO2 TDRD1 CRTAC1 TREM2 PGC NCR2 NRP1IGFALS MISP P2RX6 SLC7A4 SEC14L3 PRODH PLA2G3 LGALS2 SEZ6L RP1-37E16.12SLC16A8 SLC5A1 TPTEP1 TIMP3 APOBEC3H PDGFB ACR PNPLA3 UPK3A IL2RB CHADLKCNK10 GZMB C14orf105 PLEK2 RIN3 LGMN CHGA SLC8A3 BDKRB1 MMP9 VSX1 PROCRHNF4A SALL4 DOK5 HRH3 BIRC7 COL20A1 ISM1 SLC52A3 ANGPT4 RSPO4 PROKR2SIRPB1 FERMT1 PDYN CCM2L PLCB4 ASIP CST4 EPPIN CELF4 CDH20 LAMA1 VSIG1GUCY2F ATP1B4 CHRDL1 PAGE4 GLRA2 BMX LUZP4 SMARCA1 ASB9 PPP1R2P9 GATA1GPR50 CD40LG KLHL4 SRPX2 SYTL4 ZDHHC15 NALCN HTR2A MLNR SGCG IRG1 MEDAGOLFM4 MSLN CCL22 CCL17 NECAB2 WFDC1 FOXF1 AQP8 CPPED1 SALL1 AQP9 RASL12GOLGA8UP CD276 TGM5 PDGFRL CA2 TRPA1 SFRP1 JPH1 DKK4 SH2D4A TUSC3 ADAM2TULP2 CGB KCNA7 DKKL1 CLEC4M NOVA2 KIR3DX1 LILRB1 LILRA1 OLFM2 SYDE1CASP14 EBI3 SHD MYH14 CD33 CEACAM5 CRX SYNGR4 CABP5 LILRB5 SLC5A5 ATP4AATP6V0A4 TFEC CAV2 HOXA2 VIPR2 EVX1 CHN2 GRB10 COBL PAX4 MOGAT3 NOBOXMYL10 MEOX2 GLI3 PRKAG2 GALNTL5 LHX2 SH3GL2 PTGDS GATA3 PKD2L1 PLEKHA1UNC5B TLX1 FGF8 NEURL1 SORCS1 CYP2C18 KRT23 CRYBA1 ASPA HOXB6 SGCA ABCC3CACNG1 PMP22 SULT1E1 ODAM NMU UCP1 TBC1D9 WFS1 ANXA10 SOD3 CPZ SLC2A9CLNK HGFAC FAM149A B3GAT1 P2RX3 MS4A6A MS4A4A CCKBR FOLR1 FOLR3 APOA4UPK2 ELMOD1 CALCA VWF DAO SLC6A12 PRMT8 CUX2 GSG1 RERGL IL26 IFNGSLCO1B3 APOBEC1 NANOG ST8SIA1 RFX4 SASH1 UST OPRM1 TULP1 IL17F MDGA1RBM24 TSPO2 SIM1 COL9A1 SLC17A2 ADGRG6 PDE10A MDFI SMOC2 PRPH2 FAM46ACLIC5 TBX18 NUDT12 SEMA5A C7 GHR NME5 PCDHB5 PCDHB6 HAVCR1 IL12B NPR3AGXT2 PRLR SLC12A7 IL4 LIFR DPYSL3 PDGFRB HRH2 UNC5A CLDN16 AMOTL2 RBP2RBP1 BCHE FGF12 GNAT1 C3orf14 UPK1B SLC4A3 ADAM23 CCL20 OTOF GRB14 CLIP4TLX2 EVA1A EFEMP1 IGFBP5 EFHD1 IL1R2 PRKAG3 SMYD1 IL1R1 IL18R1 IL18RAPSLC9A2 MLPH RND3 KISS1R VAX2 ATP6V1B1 EPHA4 PARD3B PRRX1 MARK1 TNR NPHS2PDC WLS RPE65 CD2 NID1 NT5C1A SIPA1L2 ST6GALNAC5 ADGRL2 MFAP2 RGS4PLA2G2D CR2 MPL ARTN CNN3 F3 FASLG A4GNT MMP8 ZNF541 TNNT2 CTGF STBD1PCDH17 CCND2 FGF23 NR4A3 CSF3R ONECUT2 ESRRB CNRIP1 PPP1R3C PYROXD2PRLHR SFRP5 CRHR1 TEK INSL4 CCDC170 PCDHB8 TNFSF18 TTLL2 KCNJ5 KIAA1217PLXDC2 IQSEC3 ENOX1 TNFSF11 DUSP4 CHRNA2 ADRA1A NPPB TBX4 LRAT TAS2R8KCNJ8 TAS2R9 GJA3 HCRTR1 CCR2 CPXM2 TMIGD3 SV2C MYOG PRM2 OCM KIAA0087NPY INHBA ARL4A PHF24 CNTFR AKR1D1 SFTPA1 CHST3 BICC1 ARL4AP1 SSPNCCDC70 GUCY1B2 HOXC13 HOXC11 NFE2 DBH IL13RA2 PLP1 ATXN3L G0S2 DAW1 INHAOBSL1 FAM124B PI3 ARHGAP40 MATN4 GDAP1L1 EDN3 RBPJL ZBP1 MAGEA10 IQSEC2RP11-663P9.2 IRGC GRM4 BTN2A3P MOCS1 SPDEF TREM1 ATXN1 OPN5 AC105760.3EREG DKFZP434K028 SCGB1D2 WNT1 SLC10A2 BMP4 TEKT3 BARHL1 SRMS LINC00029NPBWR2 C20orf195 IL37 GRIA3 FOXA2 FAM182A BMP2 LRRN4 OTOR DEFB129 GDF5BPIFB9P AMOT SLURP1 GPR42 PRKCG PRDM7 NXF5 OMD EDN2 BCL11B IL22 TSPAN8CRYGN TRPV5 ADGRE2 IL17B TNFRSF19 KDR GAL3ST1 RFPL1 RFPL3 CDC42EP1 MCHR1GALR3 LIF KRT17 RNF112 CPA4 FOXP2 HOXD10 HOXD11 ISLR LOXL1 KCNC1 FAM64ASHBG LRRC6 MTUS1 SIGLEC9 KLK10 EGLN3 FOXJ1 CDH15 SHC2 PLPPR3 NXNL2STARD8 TSPAN16 C19orf80 CNN1 ZSCAN10 PVRL2 GADD45G LRCH2 GDF1 MAS1 PXDNGDF15 HRC OR11H1 OLFM1 SAG TNNT3 CALY RBBP8NL FIBCD1 PNCK DUSP9 LRP3PRRG1 BPIFA2 COX4I2 C1QL1 GFAP PYY CCL25 LRRC4B GFPT2 BARX1 CA6 RHOXF2FSHB LIN28A LRRC9 PPARG HHLA1 RAMP1 RGS22 BTBD3 RHBG ATP1A4 NES VSTM2LKANK4 ATP8A2 TPTE2 GPR12 CHRM3 LGR6 DCLK1 SPG20 RNF128 PRAM1 LGALS12GSTT2B MYO18B FAM83F SEC14L4 ZDHHC8P1 SFTPD TMTC1 LYVE1 DUSP26 GSTM5GSTM3 CHIA PTGFRN ADAM30 CD101 VTCN1 ANO3 CFHR4 CRB1 RERG SLCO1B1 PRH2USP26 FAM127A PIWIL4 MTNRIB HOOK1 CYP2J2 DSC2 DTNA FHOD3 GIF APLNRPDGFRA CLDN10 DZIP1 KDELC1 ADAMTS8 FAM189A2 CCNJL HNF1A TBX3 CD36 UGT2A3FAM71F1 ADGRB3 NT5E MRAP2 LCA5 ELF5 PRRG4 AMHR2 GLS2 NMBR EGR4 DYSFCHST5 KCNK1 CAPN9 LECT1 SCEL EDNRB IL6 DGKB MYCBPAP SCN2A GALNT5 GATA4HLX IL36G IL36A GAD2 KLF4 ZFP37 WDR38 OR1L4 ENPP2 IL33 CCL21 CAPN11 PI15TTPA TRPC6 MMP20 C11orf70 BTG4 POU2F3 FXYD6 FXYD2 MMP13 UNC13C UACASTRA6 ARHGAP29 CLCA2 DNASE2B CYP1B1 CYP2C8 CH25H BTBD16 TACC2 PLA2G12BOIT3 ADAMTS14 STAT4 MSTN SLC40A1 CILP HCN4 HERC5 PRKG2 GPAT3 BMPR1BTRPC3 FRAS1 SHROOM3 C4orf17 PDE6H CPNE8 SLCO1C1 COL2A1 ANP32D LRIG3 TPH2LGR5 PTPRQ LUM SDSL FOXN4 DHH ACVRL1 METTL21C RAB20 SSTR1 RTN1 RDH12SLC25A47 DUOXA1 DUOXA2 DUOX2 HDC ARRDC4 CYP11A1 GOLGA6D RLBP1 WDR93NTRK3 ITGAX CHST4 CLEC18B ADAMTS18 CDH11 CDRT15P1 ZNF287 DPEP3 TOM1L1SKAP1 ABCA8 C17orf64 ASXL3 SLC25A52 ASGR1 PIK3R5 CARD14 SECTM1 RNF165CBLN2 STAC2 CIB3 HUNK COL6A2 IL19 CBLC ADAMTS10 SLC6A3 FBN3 TM4SF5 GPR32ACPT KLK3 CTD-2545M3.6 IGLON5 MMEL1 CFAP74 PRDM16 PADI3 FHAD1 PADI1MYOM3 DMRTA2 HSPG2 TINAGL1 AZIN2 SLC44A3 IGSF3 ZNF697 FNDC7 PROK1 XCL1MAEL DPT F13B LHX9 RORC SELENBP1 FLG2 S100A8 PKLR FLG LEFTY2 SOX13 ETNK2SYT2 ABCG8 TRIM43 MALL THNSL2 THSD7B GULP1 PTH2R ABCA12 TRPM8 GRIP2CNTN4 GADL1 POMGNT2 ACKR2 FAM198A ITGA9 CTDSPL COL8A1 ADGRG7 TAGLN3IGSF11 BOC AGTR1 UCN2 SLC10A4 SLC10A6 SNCA FABP2 SFRP2 RNF175 PDGFCROPN1L ADAMTS16 MYO10 UGT3A1 GZMA MEGF10 ADAMTS19 CXCL14 LECT2 TIMD4SPINK7 CPLX2 TENM2 KCNMB1 DCDC2 SLC17A4 KAAG1 PLA2G7 DAAM2 MLIP HMGCLL1LGSN TPBG GABRR1 CLVS2 TAAR6 TAAR8 TAAR1 VIP SLC22A3 EGFR IGFBP1 ASB15ZAN STRA8 EPHA1 NLGN4X SHROOM2 TMEM47 AKAP4 CXorf36 AWAT2 CPXCR1 NXF3FRMPD3 IGSF1 GPC3 GPR119 CSGALNACT1 DOCK5 ST18 TRIM55 SLC26A7 RSPO2 MAL2IFNA16 IFNK NTRK2 SHC3 OR13C4 ZNF462 ACTL7B HMCN2 IDI2 LCN9 CACNA1BFAM171A1 PARD3 ANKRD30A A1CF CDHR1 ANKRD1 HTR7 NPFFR1 CYP17A1 INA ADAM12SYT8 PAMR1 KLHL35 TENM4 NCAM1 DRD2 GLB1L2 GRIK4 SLC22A8 ZP1 PLCH2KIRREL3 SCN2B JPH2 DUSP15 CDH22 LINC00266-1 SLC22A9 MMP3 CNTN5 KLRF1 MKXFXYD4 FCGR1A LATS2 MIA2 HNMT ADRA2A VEGFC CCDC83 PRSS23 PPP1R1C DOCK1IL18 TKTL2 ENKUR THRB DLG5 MAGI1 ME3 ADAMTS12 CCDC3 POU4F2 EDNRA AKR1C6PWWC2 SLC35F4 GFRA1 GLT1D1 RBM46 ZNF37CP KCNE4 TUBA3E HSPB8 CYSLTR2 PTHGUCY1A2 BOLL ZNF256 OLAH CCDC50 PLEKHH2 GRIA4 IGSF10 GJA1 DDX4 CLEC4FTCTEX1D1 SLC16A12 PTPRK CNTNAP4 RAB3C PLOD2 ZIC1 BMP6 PLA2R1 ADGRF1ADGRF4 FRMD1 FAM81B LURAP1L CNKSR3 TGIF2LX TMPRSS11D PID1 KCTD15 CLCA3PHS3ST3A1 SEMA3D ANKRD29 THY1 PANX3 GPR15 CERS3 ABCA9 ABCA10 TNIK WNT3APPP1R3A GBP5 MMP21 CNTNAP3B PDLIM3 WNT7A EPHB1 Sep-14 UNC93B2 ODF1 VSIG4ALS2CR11 SPAG17 SAXO1 SLC24A2 RAET1L NAT2 MAGEA8 GNA14 GNAQ WIF1 UGT2B4KCNMA1 ALX3 CFAP161 ADAMTSL3 ART3 SLC28A1 CXCL13 NAA11 FUT6 KCNS2 LHFPL4MPV17L SHCBP1L SLC6A1 SYN2 CDCP2 STEAP2 HTR5A IL34 CACNA1D ARSE KITCACNA2D3 MUM1L1 KCNJ6 ERG SVOPL SLC34A2 ACAN DPYSL5 AGAP1 SLC30A2 TRIM63GRHL3 GALNT14 XDH DZIP1L MRAS ESYT3 CLSTN2 COLEC12 SLC13A3 SHROOM4 KCNB1CPA2 CPA5 PPP1R9A POM121L2 SLAMF8 DUSP23 HTR6 ITLN2 NPM2 FGF17 DMTNWNT9B CACHD1 STC1 TNNI1 CBR3 GJD2 CLDN14 GOLGA6A SCUBE1 PADI4 CES5ACELF3 TCHH ADGRG5 DRC7 LRRC36 ZDHHC1 FAM131B LYPD5 PTGIR KALRN TMPRSS3UBASH3A CRYAA LRRC3 ZNF208 LCN1 GPSM1 HIPK4 TMEM190 PLPP7 CCR5 PTH1R HK3COL26A1 DMKN NPHS1 HCRT SIGLEC11 MPP3 IP6K3 TREML1 BCL6B PRR35 MEIOBASRGL1 TAL1 BEND5 ACOT11 LEXM BSND PLPP3 PRKAA2 SLC45A1 KNCN TMEM82 SYNCALPL TTLL10 MEGF6 CCDC27 LRRC53 VCAM1 NLRP3 KCNJ9 OLFML2B FCGR3B FAM71ATDRD5 WDR64 PKDCC IL20 C1orf145 CAPN13 KCNF1 KCNJ3 SPATA18 CFAP221 INHBBHPGDS SMCP IVL SPRR3 BMP10 PGLYRP4 S100A9 TDRD10 GABRB1 C1orf106LINC01116 SLC22A15 IGFN1 PROK2 LMOD1 ADORA1 FBLN2 SPTA1 FAM86KP WDFY3PRICKLE2 ADAMTS9 DCLK3 DNASE1L3 PCOLCE2 CXCL5 TM4SF18 TCF23 DNAJC5GCLEC3B SLC6A20 RTP3 LRRC2 NMNAT3 GRIK3 CFAP100 RHO IGF2BP2-AS1 CLDN19HAND2 MAP9 ASB5 C4orf45 TMEM144 NPY1R SLC45A2 ZNF474 F2RL1 HTR4 ESM1CDC20B ENPP6 FAM170A KLKB1 FOXQ1 ADGRF2 GRIK2 SAMD3 DACT2 FAM183BP MYOZ3GPR85 KIF6 INTS4P1 ZNF704 CHMP4C PGAM2 DLC1 HNF4G TNFRSF11B CA3 ALDH7A1BAALC FREM1 TMEM71 MAMDC2 PRSS37 CPA6 RASEF TRPV6 C7orf34 TMEM246WBSCR27 C9orf84 PTCHD1 OR1Q1 OR1K1 CLDN3 NLGN4Y AQP7 SLITRK5 ARMC3 FAT3CCDC67 GPR101 CLDN2 LRFN5 PHOX2A PKNOX2 NGB FAAH2 DACT1 BEND7 SLC18A2TMEM52B FRMD7 RET RNASE7 OTOGL SERPINA12 PDZRN4 SLC6A5 PASD1RP11-299H22.3 ADAMTS15 SVOP LRTM2 LARP6 ASPG ALKBH3 GABRB3 SCN3B TMEM100MOGAT2 SERPINB7 OR5P1P WDR72 PLD4 TMEM130 FAM86GP CLEC3A BEAN1 SLC38A8CPLX4 RRAD SERPINB12 ACSM1 STRCP1 LDHD TAC3 GREM1 NYAP1 MS4A8 CCDC178MS4A15 SGSM1 B4GALNT2 SUN5 SAMD14 TMEM92 LINC00483 C16orf92 GOLGA6C NOD2LOXHD1 RBFOX3 CD3D OR51I1 GNG8 LPO CA4 LINC00905 ZNF528 AQP2 CDC42EP5LAIR2 PSCA ATCAY TMIGD2 KLK6 KLK11 KRT80 ACER1 CD300C TEKT1 PRR25CASKIN1 RAB3IL1 SLC22A11 SCARA3 SCARA5 ZNF355P OR2B2 KCNJ4 HIST3H3 PTGDRFOXI1 ACOX2 MOBP C8orf22 XIRP1 LINC00917 BDKRB2 SFTPC PHYHIP HFE2 CHRM1ADAM18 GDNF FAM84B KCTD19 CA7 OR13J1 CTRB1 CTRB2 STXBP6 PXDC1 ROR2RP3-509L4.3 AR C8orf46 FAM110B ARMC4 PCSK9 CXCL10 SH3TC2 RP11-220D10.1SHE P2RY12 RNASE6 NPR1 COL22A1 CCDC8 CT55 GJB1 CLIC3 BNC1 ANTXR1 PROKR1LDB2 NLGN1 LINGO1 RBMY1HP CTNND2 MUC3A TM4SF4 FRMPD4 MYO7B MYRIP HMP19RNF150 CCDC144A CR848007.2 ANKK1 CNGB3 CST1 SEMA3E DCLK2 KRT78 FAM71BSLC26A5 SGCD OR5E1P TTLL6 SYT9 GPR37 OR10A4 SDR16C5 OR10A2 OR2AG1 LMOD2CELP CYTL1 OSCAR OR7G2 PKHD1 MBD3L1 PRKCDBP CEACAM3 DDI1 LINC00208 FPR2FPR1 ALK GIMAP8 RLN3 PROL1 SMR3B TMEM37 SOSTDC1 KRT15 KRTAP4-4 PDE7BKRT27 OR1L3 SSX6 OR1B1 SPACA5 COL24A1 RXFP1 NEUROD2 MAP6 PTCRA P2RY6LKAAEAR1 C1orf111 VAT1L KNDC1 ANGPTL7 PRND AQP4 FBXW10 CYP4F22 FOXB1ZNF556 MAL EPHX4 LRRC15 CD8B CALB2 MBOAT1 AZU1 TPSAB1 CLEC7A NEGR1 CERS6SPTLC3 ABCG4 OR5B2 OR9I1 INSL5 EFCAB3 TTC36 PRSS30P FUT9 C2orf54 OR10H5CTSW SMPDL3A OR10AD1 THEMIS MOS HOXC5 OVOL1 FLJ42102 MYEOV XKR3 GXYLT2HPSE2 BNC2 RXFP4 CCDC63 ACSM6 RHOD CYSLTR1 MAB21L3 VANGL1 TERF1P1 DMRT2SLC2A14 OR10K1 NDNF IQCF1 OLR1 GLIPR1L1 DAB1 CCDC36 PTPRM NLRP13 XCR1SULT1B1 HSPB7 CD7 MARCH10 RP11-89N17.1 C1QTNF1 SNURFL RP11-18M17.1 RAX2LRRC63 CD34 MSRB3 NWD2 SNX31 ADCY6 SLC16A11 GLIS1 PODN SLC6A19 ABRAVWC2L GALNTL6 LINGO2 IGDCC3 SLC26A9 TTC9B KLK15 GOLT1A NPAS4 CMKLR1 KYBRSK2 FAM47DP LEP RP11-79L9.2 WDR49 BTC CATSPERD VN2R1P SEZ6L2 P2RY14GPR171 CD164L2 CA5A ZG16 CHST2 WFDC5 TMEM51-AS1 ABO GAL3ST3 CHST1 CST6NRIP3 PCSK1 OR52W1 TSGA10IP UBQLNL P2RY2 PRM1 LINC00521 EIF3KP1LINC01106 C15orf53 CREG2 HOXD8 DOK7 LRRN1 KLHL38 ASCL3 C11orf16 TMPRSS7RP1-146I3.1 MC5R OR11H4 OR51B6 OR4F21 IDSP1 ZNF135 FOXR1 RPL37AP8PFN1P10 PRR18 OR5AN1 PRR15 MAP3K19 HORMAD2 NANOGP1 FOXC2 ZNF843LINC00303 FKBP9P1 MIR7-3HG RP11-432M24.4 GRIN1 SOX11 C8orf4 GCNT4 TOB2P1RPL7L1P11 SCN4B DSCAML1 MRVI1-AS1 LINC00982 CLVS1 SPACA4 LINC01561ENSAP3 FLJ40194 RP4-756H11.4 ERICH5 GPR4 IRX3 RP11-56N19.5 FAM187BC12orf54 C2orf57 SRRM3 FAM20C PVRL3 SLC35G5 CTD-2530N21.5 YIPF7 MYOZ1CCDC184 ODF3 LCN15 C2orf73 TSPYL6 ADAMTSL1 PRSS42 PPP1R42 RP4-682C21.5RNF212 AP000345.1 PRM3 ZNF354B OR2D3 DNAJC22 NEUROG2 CEP295NL TUBAL3 MAFOR6B3 DEFB125 OTOS ACTG1P1 C5orf64 THBD LMO7DN CPN2 FAM101A LGALS7BERICH3 C14orf39 KLHDC7A LL0XNC01-131B10.2 TRIML2 OR13D1 IGSF22 C9orf106FAM133A RP11-458F8.3 MTUS2-AS1 GIMAP7 RPS2P28 GGN HNRNPCL1 TMEM151AWSCD1 GS1-124K5.9 GATA2 VWA1 DNAJB8 OR6W1P AC073072.5 OR9A2 LSMEM2RNF151 GRM8 RPRML CDH5 OR7E22P MRGPRX4 MYADM MRGPRX3 GIPC3 C1orf194B3GNT3 NRXN1 SSC5D SPDYE7P AC079741.2 FAM71E2 ANKRD18A C12orf40 CSNK1A1LLYNX1 TH TDRP FAM71C TPT1P10 SLC9A4 ADGRD2 PNPLA1 DEFB124 KRTAP9-7CYP8B1 ZSCAN4 RNF182 C9orf139 FUT7 MB21D2 RPL21P8 SHISA2 CLRN3 CHST13ARSJ MAP3K15 CXCR2 GREM2 OR56B4 C1orf105 OR56B1 FCRL6 SLC26A11 OR52N4MAPK15 ADIPOQ SDCCAG3P2 OR52P1P C4orf50 HIST3H2A HSP90AA6P CCDC108 AATKZNF467 OR6T1 OR52H1 TMEM252 OR4C6 AP003774.4 CCDC149 RP11-651P23.2PNMAL1 ADIG USH1G TRPC2 TMEM30B CREB3L2 UNC5C LDOC1 ZAR1 SYNM NLRP10FIGN IZUMO1 B4GALNT4 MBD3L3 GLTPD2 KIAA2012 LIPF PDSS1P1 RP5-1142A6.8IFNL1 DNM1P46 OR2B8P TBPL2 CAV3 CLEC4G RP3-341D10.1 EPHB3 EPGN OR2V2CCNYL2 NTM GALR2 SEPHS1P1 RGS6 SLC35D3 HCAR2 MAGEB17 CRIP2 PLCXD3 VMO1GALNT9 ADGRG3 RP11-558O12.1 TSPEAR-AS2 TCEAL7 ODF3L1 NPM1P14 ZNF662MCEMP1 PCP4 FREM3 BEGAIN FAM43B GJD3 CALN1 GABRR3 RP5-1120P11.4 PRR36NF1P3 FAM9A SPDYE4 REC114 GBP6 SYNDIG1L TMEM89 RIPK4 ZBTB8OSP1 SH2D7GPR132 COL18A1-AS1 ACSM5 PGPEP1L GOLGA8G C11orf88 FAM19A1 LINC00518BMP8A EFHC2 OR4N4 LHFP ZNF703 SLC35F3 TCEB3C EMILIN3 FAM162B CCR4CTA-833B7.2 ANKRD45 C1orf64 SH2D1A ST6GALNAC3 TMPRSS2 TREML3PRP11-366I13.3 RPL7AP28 KCNJ12 DGAT2L6 CDR1 POU6F1 PRKD1 CCSER1 COLEC10A3GALT2 CCR10 NCMAP BPIFC POU3F2 PROS1 NUTM1 PTGER4P2 SOCS3RP13-786C16.1 FAM19A3 ZNF72P OR7E14P CLDN6 FAM110C MGAT4EP SATL1 DRD1TCEAL2 CLCNKB OR6A2 WT1 SORCS2 IFNE SLC22A10 RFX6 SLC2A3P2 SLC24A3 FLRT2FAM169B ZNF479 LINC00313 WASIR1 TNFAIP2 GAPDHP24 MAGEA11 ZNF74 KLHL33WBSCR17 NUPR1L IL3RA SFTPA2 C12orf56 GAS2L1 OR2V1 KPNA7 ROR1 TLCD2AC017079.3 POU3F1 LYG2 MORN5 SRL NLRP9 NPAP1 LINC01405 CCDC190 TMEM210TMPRSS11B THNSL1 FFAR3 RTN4RL1 KRTAP5-5 CCIN GRK1 ATP4B HTR3E TAL2 KRT5KRT18P14 AGBL4 ARGFX PRR30 UBL4B CYP4Z1 BPIFB4 EDARADD CYP4F12 MARC1SSU72P4 LCE1E AC016757.3 GPAT2 GABRA5 PRELID2 SLC36A3 SLC36A2 CYP4X1GLDN TRDN TMPRSS12 FAM228A AQP7P1 AKAP14 OR9I2P CLCNKA CEACAM19 SPATC1PDE2A SPDYE17 PRR5 EEF1GP1 CYP27C1 TPI1P3 FOXE3 LILRB4 TNFRSF4 KRT17P2CHCHD2P9 LINC01551 EMID1 C17orf82 C3orf70 TEAD1 AKR1C1 SPATA21 KRT12CIDEC DCC HIST1H1T CDHR4 COL4A1 PLEKHG7 GJA4 ATP13A5 AGMO TLR5 NANOS3TERF1P2 SAMD11 PERM1 ERC2 KBTBD12 THSD4 GABRD AMY1C OR52B6 C9orf153HSPE1P11 TMEM72 PEAR1 RP11-24M17.5 C2orf78 PALM3 C1orf168 AC097382.5LRRC74B DMBT1 OR51I2 LCN10 C2orf66 HS6ST1P1 PLA2G2C ZSCAN23 TPRG1C1orf204 RTP5 C19orf67 CLCN1 NRN1L PRSS45 DAZ1 TMEM215 COL4A5 HEPACAM2SMTNL2 RUFY4 HES4 SLC38A3 AC092171.2 C10orf99 AC018892.9 PPP3R2 GPR21TCTEX1D4 NANOS2 SLC24A5 AC003003.5 INSC CFAP77 FBLL1 PAQR9 GOLGA8MTSPY7P LINC00319 HILS1 QRFP OR13D3P TBC1D3P2 FZD9 TMSB4XP2 OPTC PLET1CATSPER4 TMCO2 DPPA3P2 ASTL GJB3 USP32P1 UTS2B MSANTD1 LRRC66 SBSN RELNAPOD GAGE2A ANKRD34B NKAPL OR14I1 MAOA AC069277.2 SPANXN3 LINC01164 GJB5ANKRD62P1-PARP4P3 RP11-797H7.5 FAM180A C6orf222 FAM179A KIAA0408 CXCL17OR7E12P USP32P3 GJB4 OR2L13 PTPRT AKR1C3 OR11H13P FAT4 KIF19 HRCT1SIRPB2 KRTAP5-3 SFTA2 CGB7 CPNE4 ELAVL3 NUDT11 FUT4 SLC35F1 THEM5NPIPB15 RFX8 ESRRG ARL9 OR9K1P CACNA1H HBG2 AJAP1 UGT2B15 HRH1 ZNF5O2SLC30A10 FAM150A LCE1B COL27A1 CTD-2192J16.17 POTEI PATE2 KRT39HIST3H2BB AC090286.4 TEX43 RP11-88G17.6 ZNF470 SIGLEC15 ZNF300P1 SLC6A17SLC22A4 OR1J2 FAM110D TPSB2 IL27 RAMP2-AS1 SVIL OR8S1 DIO3 CYP2B6HIST1H3D DCHS2 VEPH1 PDGFA AC005276.1 COL13A1 ZNF665 SLC28A3 FAM177BSSPO COL4A6 DMBX1 ZNF841 DPP4 PDCD1LG2 SLC22A24 PARVA LHFPL5 IGKV7-3ADAMTSL2 PRB3 UGT2B17 HRNR ZNF311 ZNF347 ZNF734P CLEC9A DLGAP2 FCGR1BZNF560 TUBA3C ZNF667 AVPR1B SIRPA AKR1B10 SULT1C4 CYP2A7 NUP62CLTMPRSS11F LPAR1 SOWAHC ZNF334 RP11-566K11.2 CACNA1E OR5B21 TMEM239ZNF568 RTP2 SH3BGRL2 PLN SLC34A3 RD3 RP11-611L7.2 NUDT16 MMP17 ZNF534TUSC1 MAGEA1 LINC01565 ABCA4 UNC13B PPP1R14C SMOC1 PLXNB3 EGFL6 APCDD1LMUC2 ALPK2 PAX9 LRRC10 SUCNR1 MTND4LP30 PNMA5 SOWAHA MIR210 RN7SKP184SNORA21 RNU4-39P RNA5SP477 RN7SKP173 RN7SKP74 SNORA17 RNU1-72P RNA5SP452RNU1-120P RN7SKP243 RNU4-32P SNORA71D SNORA38B SNORA63 SNORD118 RNY1P11RNU1-124P RN7SKP180 SNORA80A RNU4-1 SNORA38 RN7SKP87 RNU4-51P RNA5SP202RNA5S9 U3 RN7SKP193 RN7SKP37 SNORA55 SNORA71C RN7SKP237 SNORA16BRN7SKP50 RN7SKP78 RNU12-2P RN7SKP239 RNU1-59P RN7SKP9 RNU5E-4P RNU4-8PY_RNA RNU1-100P RNU1-51P RN7SKP69 RNU1-16P SNORA62 RNU1-122P RNU5E-6PRN7SKP230 RNU4-2 RP11-560A15.3 Metazoa_SRP RP11-277A4.4 ZNF525RP11-25I9.3 LINC01562 LINC01317 CTD-2026K11.6 RP11-217O12.1 RP13-36G14.3BTBD7P1 FAM32B E2F3P2 Metazoa_SRP HMGB1P39 TAS2R2P OR1F2P RP11-542B15.1RP5-1096D14.6 RHOT1P2 AC012456.3 LINC01285 OR2L2 TCP10 CAPN8 LINC00862SAMD5 LINC00272 FCGR3A FANK1 KPRP DDO CCDC162P PLPP4 CHIAP2 CYP17A1-AS1RP11-261N11.8 OOEP C1orf146 C10orf62 FAM127B C1orf141 GLYATL3RP11-188C12.3 LCN8 TRPC5OS LRIT2 LRRC73 FOXO6 TDRG1 NEU4 MAFB BMP2KLRP4-640H8.2 PTPN20 GDF5OS TXNDC8 AWAT1 TCEA3 OR13C3 RP11-219G17.4FLJ45079 BTNL2 C6orf10 CYP21A1P NXPE2 RP11-380J14.1 AC005042.4 LAYNRP11-410N8.4 RP11-65D24.2 CSHL1 LY6G6C XXbac- BPG32J3.20 LY6G6F MCCD1PSORS1C3 ZSCAN5CP AC096670.3 TRIM10 HCG9 NMS RPS26P8 MOG OR2H2 CBY3C9orf57 RP5-100419.1 CTC-281M20.1 ZNF204P ST8SIA6-AS1 PNMAL2 NAT8BAC021218.2 GPR20 SPINK9 LRRC3C PSG5 FAM83A-AS1 ARHGEF34P BLACE PCDHA8PCDHA2 PCDHA1 ERICH4 PRSS1 AARD RP11-46C24.3 SLFN12L LGALS7 C2orf91FAM205A ACCSL TRIQK SLC10A5P1 SCGB2B2 OR7E36P KRT17P5 DGAT2L7P MUC12CTXN3 RP11-352D3.2 MGAT4D KRT17P4 ADGRG1 MT1H MT1M LINC00661 KRT81EXOC3L4 KRTAP10-2 SPDYE18 AC013472.3 RP11-89H19.1 AF064858.6 LINC00898VCX3B CTD-2375G15.1 RP3-416J7.5 ACOT6 CRLF2 RP9P LINC01531 C16orf96TTC23L OR7E91P C22orf42 FAM99B KRTAP5-1 FAM90A2P RP11-3B12.4 ONECUT3RP11-404K5.2 IFITM5 C18orf63 DOK6 IGLL3P SERPINB5 CTD-2008L17.2 HBMANKRD20A9P ANKUB1 RP11-93O17.2 VGLL3 PRSS50 SNORA57 SNORA22 SNORA2ASNORA80B SNORA22 RNU1-73P SNORA6 RNU6-483P SNORA9 SNORA29 RNU4-52PSNORD15A SNORA76A Y_RNA SNORA54 SNORA27 SNORA72 SNORA7B SNORA25 U3SNORA70 SNORA68 SNORA37 SNORA70 SNORA8 SNORA22 SNORA20 SNORA64 SNORA19SNORA80E SNORA46 MIR7-1 AL132780.1 MIR219A2 MIR671 IGKV6-21 IGKV3D-11IGLV8-61 IGLV5-52 IGLV1-50 IGLV2-33 IGLV3-25 IGLV3-16 IGLV2-14 IGLV2-11IGLV3-10 IGLJ1 TRGV9 TRGV1 TRAV13-2 TRAV9-2 TRAV22 TRAV39 IGHV2-5IGHV3-7 IGHV3-13 IGHV3-15 IGHV1-18 IGHV4-28 IGHV3-38 IGHV3-48 IGHV1-58IGHV2-70 U3 U3 SNORA16 SNORA46 RNA5SP323 SNORA74B SNORA75 SNORA75SNORA12 U3 SNORA75 RNA5SP53 SNORA45B KRTAP16-1 KRTAP29-1 KRTAP9-6RP11-134K1.2 AP002414.1 RPS26P3 RPL23AP4 POU5F1B BTF3P12 PTTG3P SYT3RPL23AP80 RP11-383G10.3 RP11-532L16.1 EEF1A1P32 OR5S1P HNRNPA1P34 TPM3P1RPL5P5 EEF1B2P7 RP4-612B18.3 PFN1P11 RP11-760D2.10 yR211F11.2 FAM106ARP5-933K21.2 RP11-613F7.1 ACKR1 PHBP1 NPM1P46 RP3-352A20.1 RP11-306O13.1PPP1R14BP5 ARF1P2 ELK2AP RPL23AP60 RP11-252O18.3 GAPDHP36 RPL36AP48AC016732.2 ARHGEF35 RP11-355O1.7 RPL12P38 ST13P10 EEF1A1P16 RBMS2P1RPL12P42 YWHAZP5 TSGA13 RP11-613M5.1 RP11-212P7.1 RPL18P11 RPL9P18CYCSP19 RPL7AP34 ATF4P1 AC092933.4 RP4-778K6.1 NAP1L1P3 LINC00671GAPDHP71 RP11-779O18.2 RP11-66N11.6 RPSAP46 ANXA2P1 HNRNPA1P33CTB-47B8.5 KRTAP4-12 KRT222 YBX2P1 H2AFZP1 VDAC1P7 HMGB1P37 FIRRERP11-972K6.1 EIF4A1P8 ACTN4P1 TPT1P13 GBP7 AC132008.1 SETP8 AC005522.6AC005077.8 RP4-595K12.1 KRT18P19 AKR1B10P1 RP11-380G5.3 BOLA3P3CTD-2158P22.1 OLA1P2 SLC25A5P3 SEC14L1P1 LA16c-60G3.7 RPS10P14KB-1683C8.1 HNRNPA1P32 PSMC1P2 RP11-941H19.2 AC004129.9 RPL13P2 TAF9BP1RPL7AP64 RPL3P6 RP11-546M4.1 NPM1P33 HBG1 AC092610.12 RP11-94D20.1RP1-102E24.1 KRT18P17 ITGA1 KRT18P29 API5P2 RP11-264F23.1 RPL7AP14AC007277.3 RP11-414H17.5 ATP5F1P3 KRT18P38 RP11-414H17.2 ARPC3P5RP11-169L17.3 AC073310.4 PGAM1P4 IFNA7 RPL6P5 RP11-549L6.2 RPL23AP39CYP4F30P SMCO1 WEE2 RP1-258N20.3 TMEM213 ACTN4P2 RP11-488L18.1RP11-699L21.1 RNF152P1 C12orf74 SETP21 PUDPP3 RAD51AP1P1 AZGP1P1 OR1X5PAC133644.3 NEURL1B AC009967.3 RP11-457K10.2 LCNL1 GOLGA2P8 SEC14L6HIGD1C KRT42P AC130709.1 AP000343.1 AC087491.2 MEG3 POLR3DP1RP11-392M9.2 IQCF6 AC090616.2 CDIPT-AS1 RPL5P35 RP11-429J17.8RP11-54I5.1 AC004870.5 CTD-2509G16.1 HNRNPA1P15 RP5-1053E7.3 HMGB1P4RAD51AP2 RP11-115L11.1 APOC1P1 LINC00243 RP11-229M1.2 RPL23AP3RP11-674E16.4 SPATA31D1 TBC1D26 ISPD RP11-274J2.1 RPL7AP26 HSPD1P7AC114730.5 PRDX2P1 PKMP5 DUSP8P4 DUSP8P3 RP11-30M20.1 NLRP2P MUC5ACGOLGA6B UBE2QL1 LA16c-60G3.8 RP11-62E14.2 NPM1P12 ZNF705D RP11-754I20.1CTAGE12P RP5-890O15.3 BCRP4 RPL27AP FAM230B LINC00189 TTTY5 CNN2P7 GAB4RP5-967N21.2 C20orf202 KRT18P35 GCGR CELA2B LRRC37A14P RP11-364B6.2FEN1P1 MARCKSL1P2 RPL23AP17 C1orf167 MMP23A KRT19P2 RP11-360O19.1MRPL42P2 RPL12P2 RAET1M LINC00955 GAPDHP72 RPL7P25 RP3-355L5.3RP11-812I20.2 TUBB2BP1 AL022393.7 AC131097.4 RP3-329A5.1 RP1-13D10.3RP1-245M18.2 LARP1P1 RP11-360O19.5 RP1-319M7.2 RP1-182O16.1 AC018865.5OR2W2P SSXP10 RP11-474L11.5 RP11-477E3.2 RPS16P5 IQCB2P PTGES3P2RP4-803A2.1 HIST1H2BPS2 RP1-95L4.4 CCT7P1 RP1-303A1.1 RP11-160A9.2AC099552.4 HIST1H4PS1 OR4F7P KRT18P48 HSPE1P8 CICP18 ZNF192P2 PRKRIRP5KRT18P22 KRT8P43 POM121L14P RP11-367G18.2 RP11-393I2.2 HNRNPA1P1 NIP7P3H2AFZP3 RP11-12A2.1 GAPDHP63 RP11-2J18.1 RPL7P28 RPL5P20 AC010150.1RP1-34L19.1 RP3-453I5.2 RP3-340B19.5 HSPD1P16 TDRD15 FAM138C RP1-209B5.2CNN3P1 RP11-528A10.1 SOD1P1 RP11-214N16.2 AC011298.2 HMGB1P20 RPS20P2RP11-397G5.2 RP11-491H9.3 RP11-106E7.1 TEX40 RP11-3B12.3 RPL17P25ZNF259P1 HIGD1AP16 RP11-262H14.11 RP11-532F6.2 RP1-199J3.5 VN1R11PRPSAP45 ATP5F1P6 RPL35P3 RP11-394A14.2 LAP3P1 RP11-307I14.2 AF238380.8HNRNPA1P12 FLJ35934 RPS24P12 RP11-230C9.1 RP3-431A14.4 KRT8P42RP3-520B18.1 YAP1P1 RP1-177A13.1 TUBBP9 RP3-509I19.6 RP3-406A7.3RP11-277I20.3 RP1-92C4.1 IGBP1-AS2 HNRNPA1P41 U3 SNORA11 SNORA81 SNORA34SNORA3 AL590226.1 MIR1307 C7orf65 CTD-2527I21.4 PLXNA4 HMSD NPTXR HEPN1TAS2R40 PRR21 TMEM14EP TTC4P1 LINC01118 PSMB11 LINC01124 AC079354.3POTEM POTEJ RN7SKP285 RNU2-65P RN7SKP16 SNORA73 RN7SKP151 RNU2-17PRN7SKP114 RNU2-33P RN7SKP221 RN7SKP158 RNU2-28P RN7SKP271 SNORA79RNU4-25P RN7SKP235 Y_RNA RNU2-70P RN7SKP123 RN7SKP38 RNU2-7P RNU2-68PRN7SKP259 SNORA57 RN7SKP165 RNY3P8 RN7SKP30 RN7SKP273 KLF2P3RP11-224O19.5 RP11-374M1.4 RP11-408H1.3 RP5-858B6.3 AC016716.1RP4-800M22.2 RP11-274J16.5 RP11-52I18.1 RP11-285G1.9 AC064834.2RP11-310H4.1 RP4-788P17.1 MAPK6PS2 CHCHD2P5 RP11-15M15.1 RP11-763B22.7RP11-397P13.7 RPL23AP53 RP13-297E16.4 KIF28P EEF1A1P8 RP11-24F11.2SMPD4P1 TNRC18P2 RP11-275I14.2 CKMT1A RBMX2P3 RP11-61K9.2 RP3-476K8.4AL356806.3 RP1-292B18.4 EBLN1 AC125634.1 MTCO1P17 AK4P4 AC008277.1RP11-131L23.1 AC012314.20 CTB-111F10.1 EEF1A1P24 RP11-93B14.4 IFNWP18ADH5P3 RAET1E-AS1 SFR1P2 RP5-1172N10.2 LINC01208 RAD17P2 AC007879.5RP11-145E17.2 RP11-321C24.1 RP11-644K8.1 AC007389.2 PSMD4P1 MIR503HGAC008073.9 MED15P9 RP11-54O7.3 RP11-307B6.3 LGALS8-AS1 RP11-403I13.4RP4-593M8.1 BOLA3P4 KRT8P28 AC004870.4 AC008074.4 HLA-DPB1 AC006372.5AC005517.3 GNL2P1 RPL23P4 AC068657.2 ZNF32-AS3 EEF1A1P36 AC079630.2DPPA2P1 RP11-353H3.1 RP11-430G17.1 RP11-458I7.1 PRKRIRP8 ZNF587P1AC002456.2 DDX11L1 BNIP3P42 SMCR2 RP11-528A4.3 AC104809.2LL22NC03-102D1.18 RP3-471M13.2 AC019070.1 RP11-488L18.6 RP11-728K20.1RPL21P32 RP11-274B18.3 AC091493.1 IGKV3D-15 RP11-30O15.1 EGFR-AS1RP11-430K21.2 AC009487.4 AC091729.7 LINC01057 RPL23AP41 AP001630.5ATG12P2 POM121L10P DPPA2P2 MIR548XHG AMMECR1-IT1 RP11-309L24.6 HAGLRRP11-10L12.1 AL590762.6 LINC00466 AC104699.1 OR2L1P AC110299.5 MRRFP1WARS2-IT1 AC090044.2 LINC00403 LINC01133 RPSAP18 RP11-191L9.4 AC005077.7ENSAP1 MSL3P1 RPL7P7 RPL12P14 DPRXP1 AP000357.4 RP11-496H15.2 BICD1P1RP11-462G2.2 MTND2P5 RP11-252P18.1 RP11-814E24.3 RP3-417O22.3RP3-395M20.2 LINC01280 LINC01272 OR6D1P RP5-956O18.3 AC010886.2SLC31A1P1 MKRN5P RPL23AP14 AC017035.2 ATP5F1P1 RP11-439L18.2 PGAM1P6CDCA4P2 AC009313.1 AC073900.4 RP11-495P10.3 TTC21B-AS1 RPL36P4MAPKAPK5P1 KRT8P45 PPIAP10 AC008264.4 RP11-370B11.3 HMGB3P21 AC008065.1RP11-438N5.2 RP11-430H12.2 AC012314.19 RP11-365D23.2 RP5-884C9.2RP11-30B1.1 ZMIZ1-AS1 RPS5P2 BMS1P12 AC096921.2 AC106053.1 PDSS1P2AC106900.6 RP11-397D12.4 AF124730.4 IGHV3-74 LINC00885 PDIA3P2 GAPDHP46ZNF812 UBE2D3P3 RPS17P13 OR11M1P AC025165.8 CITF22-49D8.1 RP11-576D8.4TEX26-AS1 RP11-380G5.2 VN1R21P LINC01167 CR769776.3 MUC20P1 RPSAP50AC006026.9 AP000704.5 KRT18P39 RP11-445O16.3 RP11-235D19.2 TUBB4BP2LINC00853 BEND3P2 SEPT14P13 RP11-307E17.9 RP11-134G8.10 LINC00265-2POPA1-AS1 GXYLT1P2 MTCYBP29 AC007899.3 VPS26BP1 RP11-3B12.5 TIMM8BP2KRT8P30 LINC00184 RP11-82L18.2 PSAT1P4 RP11-403H13.1 LARGE-AS1RP11-160H22.3 RP13-228J13.9 RP11-409K20.7 RP13-228J13.6 RP13-348B13.2AP004289.1 AC091492.2 AC096574.4 RP11-132N15.1 RP11-383G10.5GS1-184P14.2 RP11-426L16.3 WWC3-AS1 RP11-123N4.4 DAP3P1 AL450226.2RP11-15B24.1 SNORA71A RP11-405O10.2 ATP6V1E1P1 AC083900.1 RPL23AP36RANP4 MORF4L1P4 PGBD4P5 AC073957.15 AC012354.6 CTD-2538A21.1 BRI3P1RP5-828K20.1 OSTM1-AS1 RP11-795A2.2 ATP5LP4 AATK-AS1 RP11-388K2.1RP11-481K9.4 ZNF33BP1 LINC00092 RP11-197M22.2 SMARCE1P1 AC007362.3 HSPA7RPL21P10O7 RPS2P1 ZNRF2P2 RP11-466F5.4 RP11-536C5.2 AC018693.6AC005105.2 MTND4P4 RP11-344A5.1 RP11-1086F11.1 RP11-512N4.2 LINC00350LHFPL3-AS2 HMGB3P1 RPL21P66 SNX18P3 RP11-820K3.2 RPF2P1 MIPEPP1PPP1R26-AS1 RP11-3B7.1 AC010878.3 RP11-207C16.4 RP3-509I19.1 AC019330.1AP001626.1 LINC01504 RP4-665J23.2 RP13-93L13.1 ZNF70P1 RFPL1SRP11-262D11.2 RP11-120J1.1 RP11-38J22.2 GBP1P1 AC104651.2 RPL15P4RP11-330C7.3 CYP4A22-AS1 AC005237.4 PAWRP1 LINC01393 ZNF385D-AS1RP11-210H10_A.1 AP000320.6 UBE2D3P2 FAM197Y8 RP11-384B12.3 DRAXINP1EDNRB-AS1 LINC01623 MTOR-AS1 RP11-325P15.1 RP11-70C1.1 ZNF469RP4-604A21.1 HNRNPA3P15 PABPC1P12 RP11-70P17.1 AC005487.2 EIF2S2P5RPL14P5 FCF1P6 CCNT2P1 AL163953.2 FAM225B AC005522.7 PTPRD-AS1RP4-742C19.12 FAM66E AC007000.10 AP001627.1 NPM1P18 LL22NC03-88E1.17AC017002.4 AL773572.7 RP11-267N12.2 RP11-417O11.5 LINC01389 DHRS4L1RP4-603114.3 OR6V1 AC073321.4 MTND4P23 WARSP1 UBXN7-AS1 RPS18P1 NIPA2P1RP11-46A10.2 LINC01529 LINC00694 BMS1P11 RP11-288L9.4 RP11-6J24.3HSPE1P13 RPS27P16 AC009310.1 CACYBPP1 RP3-395M20.7 CTAGE4 RP4-566D2.1PCA3 RP4-575N6.4 C5orf67 NTF4 NRIR RP11-192N10.2 AC010746.3 AC102953.4HMGB1P26 RPL23AP34 RP11-312J18.3 SEPT14P3 RP11-403E24.1 COX5BP7RP11-57H12.3 CDY10P YBX1P8 ZNF503-AS1 MTND4P32 RP11-24H1.1 SLC39A12-AS1EIF3LP3 LINC00937 SEPT7P3 AC111200.8 AC098823.3 RP1-228P16.7 RP1-138B7.5RPS27AP3 SLC25A39P1 LINC01375 LINC00685 RP11-328D5.1 AC007790.4 RPS12P5RPLP0P1 LEMD1-AS1 RP11-276H19.1 RP1-310O13.7 LL0XNC01-221F2.2RP1-18D14.7 PSPHP1 RPL12P10 RP1-80N2.2 OR52I2 RP11-528N21.1 SMARCE1P2RP3-323P24.3 LINC00351 CROCC2 RP11-217B7.2 AC083822.2 HAGLROS AC102948.2ST7-AS2 RP11-358D14.2 MRPL23-AS1 IGLV3-4 AC093642.4 HMGN2P7 RP11-111F5.6RP11-1L9.1 AC018641.7 RP11-551L14.4 OR7H1P RPSAP21 USF1P1 AC104655.3UPK1A-AS1 FAM138B AC126365.1 AC074375.1 BTBD9-AS1 RP11-417L14.1 MYL6P1RP5-1092L12.2 NPM1P49 TRAF6P1 CYP4F26P RP11-505O17.1 RP11-258F22.1UBE2V1P5 IFNWP9 AC017060.1 PAPPA-AS2 AC083855.5 AC092155.4 LINC00974UBE2V1P1 RP13-13A3.1 RP11-128M1.1 AP006216.10 AC019118.4 OR13Z1PRPL23AP30 CHMP1AP1 RP11-526D8.7 RP11-509J21.4 LINC01108 PWWP2AP1 NPM1P4SMCR5 DISC1-IT1 TAS2R46 FABP7P1 GAPDHP54 RP11-654E17.2 TBCAP1 TLK1P1RP1-167F1.2 OSTCP8 AC011893.3 RP5-881L22.5 RP3-419C19.2 RP11-278H7.1PAICSP3 AC004112.4 DUTP3 RP11-569A11.1 AC002472.11 RP11-575L7.2RP4-782L23.2 LA16C-395F10.1 LINC01359 RP11-298J20.3 HIST1H2BPS3 ISCA2P1NRBF2P2 LINC00161 RBMY1J ALG1L5P RP4-714D9.4 RP4-533D7.4 MTCO1P21AC003088.1 ABHD17AP6 RP4-591B8.2 RP11-544A12.5 AL049758.2 FUNDC2P4RP11-234N17.1 LINC00511 GTF2IP7 RP11-395B7.4 RPL6P2 ANHX RP3-340N1.2RP11-12A16.3 FOCAD-AS1 RP3-466I7.1 AC107983.4 RP11-460N20.4 RP3-471C18.1RPL12P44 RP11-545A16.3 DDX11L16 PGCP1 RP11-6C10.1 RP1-45I4.3 MIR663AHGAC009518.8 RP11-121A14.3 CNN2P1 RP5-1100E15.4 SPATA13-AS1 CICP17 TTC39DPRP11-330M2.3 YWHAZP7 RP11-96L7.2 KRT16P2 RP11-95I16.2 RP1-228H13.1RP11-258C19.4 THRAP3P1 MTND5P25 AC079753.5 PPIAP2 RP11-571F15.2 HPN-AS1RNF6P1 AC008746.3 AMYP1 ZMYM4-AS1 RP5-1042K10.12 RP11-109P14.2RP11-397P13.6 MRPS21P2 AC069213.4 FCF1P1 MTND4P30 RP11-158D2.2 LINC01537AKR1B15 RP11-295P9.2 CTA-342B11.1 RPS20P15 RPL7P6 RP3-323B6.1 SFR1P1AC018647.3 RP11-139K1.2 LINC00376 RP13-140E4.1 RP11-119F7.3RP11-162A23.5 ATP5G1P5 RP1-28O10.1 RP1-167A14.2 CERS6-AS1 RP11-492E3.2PHBP11 RP11-431K24.3 SOX21-AS1 RP11-522L3.9 ISCA1P6 UST-AS1 CYCSP24LINC01068 AC087499.10 HNRNPA3P2 RP1-266L20.4 MTND6P18 AC006042.6RP4-565E6.1 CALR4P AP000344.4 VTI1BP4 AC072062.3 RP4-738P11.3 AC007365.4RP11-248J23.5 FAM212B-AS1 RP1-180M12.1 MRPS17P9 AC008850.3 AC093166.2RP11-184B22.2 SEPT2P1 DPY19L2P3 C1orf234 PSPC1P1 FAM66A OR5P4PRP11-141M1.1 RP11-143M1.3 RP6-102O10.1 UQCRBP2 AC003989.4 RP11-312B8.2MTND5P1 DHX9P1 RP11-350G8.5 ZNF680P1 RAPGEF4-AS1 HNRNPA1P46 HCG20AC069257.8 AC019084.7 HSPD1P9 RP4-781K5.4 RP11-15B24.2 RP11-151F5.2RP11-69E11.8 Z83001.1 BOD1L2 IFNA14 PNKDP1 AC003991.3 RP11-15B24.3AC099684.1 LINC01494 RPL3P1 RP11-84A14.4 AC004941.3 RP13-57D9.3LL22NC03-23C6.15 AC097713.3 RP11-455B2.9 RP11-363H12.1 PTPN2P1AL022341.3 RNF144A-AS1 LINC00693 AP001476.4 EFCAB14-AS1 GS1-304P7.2MOB1AP1 RP11-127L20.3 ARMCX3-AS1 AP000593.5 RP11-220I1.4 RP4-686C3.7BMS1P17 GAPDHP45 RP11-522L3.5 RP11-730A19.5 RPL17P43 MIR646HG RPS26P4CELSR3-AS1 RP11-365F18.1 AC106873.4 TXNDC12-AS1 RP5-1125A11.4RP4-575N6.2 AP001468.58 RP1-111D6.3 CDY4P RP11-549L6.3 RP4-633I8.4RPS15AP9 RP11-176D17.3 U51244.2 GRK5-IT1 LINC01013 AC006460.2RP11-339B21.8 RP11-281A20.2 RP11-236F9.2 RP5-1087E8.2 AC073326.3RP3-340B19.3 RP11-114M1.1 AC013436.6 MACC1-AS1 RPL7P52 RP5-872K7.7AC093166.3 ZNF883 RP11-495P10.9 HOTAIR RP4-534N18.2 AC005152.3AC008940.1 RPL23AP58 RP11-791O21.5 RP11-20O24.1 KRT18P1 TRGV5P TTC3-AS1RP4-676J13.2 RP11-492I21.1 RP5-826L7.1 RP11-155G14.1 AP001065.15RP11-316K19.3 AC008781.7 RP13-39P12.3 LIMS1-AS1 AC007327.6 RP11-336N8.3LINC00266-4P HCG22 AC113607.2 RP11-253D19.1 AC073641.2 LAMA5-AS1MARK2P13 RP1-305B16.3 RP11-293F5.8 CT45A5 RP11-112J3.15 ATP5G2P4AC096664.2 RP11-439E19.6 AC008281.1 OR1H1P AP000355.2 AC002069.5SNRPD2P1 AC004485.3 SLC25A6P5 SATB1-AS1 HCG23 UBTFL6 RP11-107G24.3EXOSC3P1 RP5-979D14.1 RP11-224O19.4 RP11-88I18.3 AC067945.3 HMGN1P2DUTP1 AC074338.4 TRBV23OR9-2 PSMA6P2 LINC01548 OR51AB1P AC068491.2AGBL5-IT1 ACTG1P2 SNX18P4 TCP1P1 AC108059.4 RP11-775D22.2 AC103564.7LINC00200 KCTD9P6 LINC00582 AC022201.4 PPP1R12BP1 PNPT1P1 AC098973.1LINC00377 RP11-552D8.1 LRRC37A12P RP11-227H15.4 AC004691.5 AC091493.2RP11-483F11.7 RP1-40E16.2 RP4-580N22.2 AC069154.4 RP11-135A24.2AC006947.1 GK-IT1 RP11-193I22.2 AC007563.3 RP4-639J15.2 SZT2-AS1LINC00452 AC147651.5 MIR5689HG RP11-494O16.3 SFTA3 RPL27AP8 AC007349.4ANKRD26P4 THEMIS3P LYST-AS1 ACTG1P11 RPL39P18 AC105053.3 AC092155.1MYCBP2-AS2 AC053503.4 AC079776.1 RP1-153P14.3 RP4-717I23.2 RPL21P44MYL8P AL590762.10 RP11-390F4.10 MTND5P2 METTL21AP1 AC007879.7 RPSAP22LINC01150 AC007327.5 AC114755.5 RP11-305L7.6 AC011242.5 KARSP1 EEF1DP3RPL23AP19 RP11-556N4.1 U91324.1 RP11-567B20.2 RP11-142M10.2 DYNLT3P2RP4-644L1.2 AC013444.1 AC118754.4 SNRPFP2 RPll-522L3.11 XIST CCNB1IP1P1RP1-308E4.1 RP5-1174J21.2 AC093899.3 RP5-837O21.4 PGA3 RP11-505P4.7RP11-363N22.2 OGFR-AS1 EIF1P1 PAICSP5 HNRNPA1P6 RP11-206L10.4 AC016999.2RPS4XP5 RP1-151F17.1 PRPS1L1 RP11-111F16.2 RP11-93N20.1 B3GALNT1P1FLJ31356 RP11-135A1.3 RP5-1119A7.10 LINC01435 RP11-15I11.2 RP11-574K11.8AKR1B1P1 HMGB3P9 SNAP47-AS1 RP4-568F9.6 RP11-217B7.3 RP11-481H12.1FNTAP2 RP11-95P13.1 CDY11P BIRC6-AS1 AC017104.4 RP11-402G3.5 TRPM2-ASRP11-384C4.6 CDC42-IT1 MTAPP2 STK24P1 TMEM254-AS1 RP11-407B7.1AC018712.2 RP11-431N15.2 CTA-126B4.7 RP11-275N1.1 AC091177.1RP11-163G10.2 EEF1A1P39 RP11-282I1.1 RP4-539M6.18 RP11-305L7.5AC018463.4 ATP5G1P1 HNRNPA1P28 LINC01149 OR4F3 AC005518.2 ATP6V0CP1HSPB1P2 RP11-173G21.1 FMO7P RP11-108M9.2 RAD23BP2 NFE4 AC002539.1MIRLET7DHG HERC2P4 RP1-40E16.9 PGAM1P3 RP11-213G2.2 CICP6 ELOVL2-AS1FEZF1-AS1 BEND7P1 RP3-323N1.2 RP13-455A7.1 NCAPD2P1 RPL23AP52 KARSP2RP5-1139I1.1 AC018717.2 AC007163.6 RP5-902P8.10 LINC00856 XX-C2158C6.1RP11-313A24.1 AC114803.3 CTF2P NEK2P4 ANKRD18B U73166.2 RP11-741G21.1AP000695.6 ATP5G2P3 AC124057.5 OR51A10P AC108463.1 COL6A4P1RP11-297A16.2 BASP1P1 RP11-379C10.4 RP11-305L7.1 LINC00102 HMGB1P11USP17L1 AC092162.1 AC114763.1 AC027612.3 OR6R1P RP13-228J13.5 CCT5P2AC093609.1 RPSAP8 RP11-402G3.3 TSEN15P2 RP11-469A15.2 RP4-781K5.6 DNM3OSRP11-359N11.1 RP5-996D20.3 RGPD4-AS1 PRB4 PRKRIRP1 CEACAM22P AC067945.2SAP18P3 RP11-681L4.1 LINC00332 GGTLC4P RP11-14C22.6 RP4-612B15.2RP11-296L22.8 RP11-478K15.6 AC007036.4 ZNF341-AS1 SNAP23P AC009961.2PSAT1P3 ARHGAP26-IT1 SMARCE1P5 RP11-243J16.8 C2orf27AP3 SRGAP2-AS1KB-288A10.17 RP11-417B4.2 CTD-2186M15.1 AC007349.7 RPEP3 AP001187.11RPL31P2 GOT2P2 LINC00486 FAM204CP AC004840.8 TMBIM7P RP11-395C3.1MIR205HG RP11-314C16.1 RP3-452M16.1 RPL12P15 MTND5P8 RP11-346K17.3OR52B5P RP13-26D14.2 AC105402.4 RP4-760C5.3 AC008154.4 RP11-298J23.5PRELID3BP11 RP1-34H18.1 HLA-T ARHGAP42P2 RPL7P56 EEF1B2P1 RP11-38L15.3RP11-34D15.2 RP11-462B18.2 FARP1-AS1 ZBTB46-AS1 LINC01510 GS1-600G8.3RP11-1M18.1 TRIM31-AS1 LINC00349 RPS3AP3 PSMC1P3 PCED1CP C17orf105IGKV1OR2-108 EZH2P1 TBL1XR1-AS1 RP11-310H4.6 RPL34P6 AC017006.3 VDAC1P6RP11-444C12.1 AC006028.11 AC072052.7 HMGN2P16 NDUFAF4P4 RNF2P1AC007919.19 RP11-310H4.3 RAC1P3 RP11-83J16.1 AC016700.6 AC006050.2LINC01516 RP11-343N15.2 FAR2P4 RP1-14D6.7 AC097359.2 RNASEH1P2RP5-1170K4.7 AC141930.2 RP4-535B20.1 LINC01347 AC007285.7 RP11-187A9.3HINT1P1 FBXO36-IT1 RPS6P2 RSL24D1P11 OR55B1P PTCHD3P2 RSL24D1P3AC091814.3 RP11-245P10.4 Z95114.3 LINC01363 AC021021.1 RP5-943J3.1RP11-296O14.2 CTD-2104P17.1 LINC00283 ATP5BP1 AGBL5-AS1 GHc-210E9.2FSIP2-AS1 AC011742.3 RPS8P6 OGFOD1P1 OR7E111P RP1-27K12.2 NANOGP5RP11-367J7.4 AC004895.4 AF064860.7 COX6CP2 VN1R110P ARHGEF9-IT1RP11-164H5.1 RP11-183I6.2 AC092652.1 LINC01354 AC090960.1 RPL31P50RP11-317B17.3 LINC01388 LINC01198 C18orf42 AC016735.2 RP11-216N14.5XX-FW83128A1.2 HMGB3P14 AC067945.4 AC007875.2 OR5K2 AP001625.5 NDUFB1P1MTND5P15 RP11-29B9.2 SETP10 GAPDHP37 RARRES2P3 AC007682.1 HS1BP3-IT1RP4-706G24.1 GNAI2P2 RP5-967N21.7 RP11-12D24.6 RP11-452K12.7 LINC00202-2AC011899.10 RPL7L1P12 RP11-57H12.2 CAP1P2 RP11-571E6.4 AC074183.4 FAAHP1AC007391.2 ZBED9 RP11-45J1.1 LINC01105 RP1-302D9.3 MRPL35P2 LINC01031LARGE-IT1 RPS6KA2-IT1 RPL31P7 AC079781.8 AL022344.2 RP11-149I23.3RP13-30A9.1 LINC00867 RPLP1P13 RP11-100G15.2 RP1-313L4.3 TOMM22P2AC098824.6 RP3-477M7.5 OR2L6P FTLP8 RP1-149A16.16 LINC00202-1 CDY3PASCL5 BTF3L4P1 XXyac-YX155B6.5 OR52I1 IFNWP15 MTND1P32 RP1-292B18.3AC012485.2 RP11-557H15.4 RP1-249I4.2 AC009299.5 RP11-395C17.1 RPS27AP2RP11-46O21.2 SEMA3B-AS1 ATP5LP2 RP1-102D24.5 RP5-882O7.4 MTCYBP3RP11-308D16.1 OR52U1P NDUFA5P1 RPL5P6 TMPRSS11CP RAD17P1 RP11-511111.1RP11-234K24.3 AC009495.3 CTB-51J22.1 RPL31P15 GXYLT1P3 RP11-103C3.1RP11-487I5.4 RP11-416N4.1 RP4-794H19.1 LINC01450 RP11-337A23.5RP11-241F15.7 TGFB2-AS1 RASA3-IT1 SAPCD2P3 RPL12P11 MRPL45P1 VDAC1P13RP4-673D20.3 RP1-257I9.2 RP11-63K6.7 SRD5A1P1 RSU1P2 RP4-591N18.2RPL23AP35 CTC-303L1.1 LL22NC03-22A12.12 LINC01412 TIMM9P2 RPL23AP31RP11-175B9.2 RP11-365O16.3 HLA-DQB2 MTND2P23 RP11-342C20.2 AC008073.7FAM136BP ACTG1P21 ATP11A-AS1 LINC00442 HSPE1P9 AC012370.2 AC017006.2NUTM2HP RP4-669P10.16 AC016831.6 TRIM80P YWHAEP1 AC007551.2 RP11-767C1.1RP11-15B24.4 RP11-177A2.5 RP1-85F18.6 ETF1P1 RP4-784A16.4 RP11-498B4.5RPL23AP50 OR11I1P FTH1P25 HNRNPDP1 RP11-204M4.1 PRR13P1 GSTO3P LMLN-AS1AF131217.1 RPL34P27 RP4-665N4.4 TRBV29-1 RP11-544M22.3 MTND6P24 USP12PYRP11-98D18.2 RPL23AP87 RP11-390F4.2 IPO7P1 HSPA8P18 LINC00374 HMGN2P20POLHP1 CYP1B1-AS1 RP11-146N23.4 CICP26 AC067959.1 NALCN-AS1 RPEP4SLC9A3P1 HDAC1P2 RP5-908M14.5 FAM204BP AC097523.1 AC016700.2 TTLL7-IT1LINC01271 RP11-5P18.5 RPL23AP25 LINC00892 RP5-837O21.2 MTND3P17RP1-67K17.3 RP11-537A6.9 SYF2P2 HMGA1P8 RPS24P6 RP11-259F16.3RP11-536P6.3 RP3-468B3.2 KLF4P1 RP11-324I22.2 RP11-216N14.9 CNOT7P1NPIPB7 RP3-339A18.6 RP11-445K13.2 RP11-558F24.2 TRGV2 AC009960.3AC018878.3 ZNF90P2 RP11-307L3.4 AC092664.1 RP11-324F21.1 RP4-569D19.5AC104809.4 AP000688.29 PRKAR1AP RP11-296A18.5 RP11-104L21.2 AC012065.5KRT18P67 CYP2AB1P LINC01077 AC125238.2 U40455.1 KRT18P62 RP1-187B23.1RP3-467K16.2 HNRNPA1P60 OR5B1P LINC01518 HCG21 RP1-122K4.2 AC017104.2LINC00690 KRT8P15 RP4-635A23.3 RP11-153K11.3 BTF3P5 RP11-62H7.2 DDX11L10CYP2T1P PGAM1P11 RP5-905G11.3 RP11-491H19.1 OR52T1P CICP1 AC093388.3SPIN4-AS1 AC083899.1 HNRNPA1P27 CEACAMP1 RP11-312J18.7 RPL22P11RP11-342M1.7 AC012506.2 LL22NC03-30E12.11 LINC00284 RPL36AP13 AP001628.7AC004947.2 MTCO1P20 RP11-154P18.2 AP001442.2 AC139887.4 AP000695.4RP11-535M15.2 RP11-135A24.4 AC017078.1 ETF1P3 AC093732.1 AC104113.3AC022201.5 AC026904.1 RPL7P44 RP11-182110.2 MTCO2P17 EZR-AS1 LINC01503XXbac- RPS15AP40 BPG181B23.6 RP11-154D17.1 AC004012.1 LINC01360RP11-288L9.1 RP11-310H4.2 AC016735.3 FDPSP2 RP11-297H3.3 RP11-379J5.5AC013439.4 IGKV3OR2-268 CTD-3105H18.11 RP11-214N15.5 RP11-236P24.3 TXNP6RP11-254B13.4 RP11-452D2.2 FAM96AP1 LL0XNC01-237H1.3 LINC00463 EDDM3CPTPRG1-AS1 RP3-388E23.2 MTND4P11 KRT19P4 RP11-145A3.4 RP11-288G3.4RPL13AP6 RPL23AP83 AC055764.1 RP11-395L14.3 TCEB2P1 RP11-64P14.7RP11-730A19.9 MTCYBP1 AC004854.4 RP5-887A10.1 LINC01191 U82671.8RP5-1050D4.2 RP1-67A8.3 FHP1 RP4-704D21.2 RPL7L1P1 RP11-353N4.5RP11-430L16.1 AC012370.3 RP11-146I2.1 RP1-138B7.4 RPL30P2 COX7BP2RP11-213H15.1 RP13-16H11.7 CLYBL-AS1 RP11-432J24.3 RPL9P2 MRPS10P2BCAS2P2 RPS26P47 PFN1P3 RPSAP31 SNX18P7 AC007278.3 RP11-561O23.5 ELK2BPCCDC188 RPL5P7 CICP13 RP11-213G2.1 RP11-528G1.2 RP11-666F17.1RP11-1275H24.1 AC005534.6 RP11-211N8.6 RP11-266I3.1 CLDN34 RP11-496N12.6OR7E46P RPL13AP20 GS1-124K5.10 FYTTD1P1 C5orf58 PPP1R2P1 RP11-37L2.1RP11-100G15.7 RP3-510D11.2 LINC01309 AC022431.3 TPMTP2 RP4-784A16.1FABP5P14 AC010096.1 RP11-5P18.1 RPL7P11 AC016894.1 OR7E155P AC104820.2ACTBP13 NUS1P2 AC073283.4 GPR50-AS1 RP11-225H22.4 VDAC1P3 PRUNEP1TUBB8P11 CTB-107G13.1 ATP5A1P8 LL22NC03-123E1.5 AP002381.2 RP11-203H2.2LINC00412 LINC01103 RP11-483H20.4 AC114730.7 RFTN1P1 FAM197Y2 AC090505.5LINC01135 U91328.2 AC092687.5 RP11-5P22.1 LINC01239 CDC42P2CTD-3105H18.7 NDUFA5P3 PIGFP2 MTND5P26 AC007879.2 RP11-384C4.7AP000344.3 RP11-101O6.2 GRID1-AS1 SDHCP3 AC104667.3 RP11-356I2.1LINC00700 SHISA8 RP11-534L20.4 RP11-280O24.3 XX-C2158C12.1 CUBNP2AC013429.5 AC016745.3 SNRPCP19 RP11-344B5.4 AF121897.4 RP11-109I13.2AP001626.2 AC097468.7 MNX1-AS2 BMP7-AS1 RP11-61I13.3 AC098820.2 RPL7P8LINC00940 RP11-637O19.2 VDAC1P4 FNDC1-IT1 RPL7L1P3 WI2-85898F10.1RP11-1217F2.1 RP11-83A16.1 RP11-90L20.2 AC128709.3 AC013474.4 COX6CP17RPSAP16 RP5-857K21.2 RCBTB2P1 LINC01366 RP11-348H3.4 RP11-613C6.4AC009495.2 RP1-3E10.2 RP11-121A14.2 TUBBP6 RP11-236P24.1 RP1-151B14.6DANT2 RP11-384B12.2 AC010240.2 TMEM185AP1 KDM5C-IT1 FLJ41941 AC137723.5MRPL53P1 GXYLT1P6 AC012360.4 GEMIN2P2 AC005301.8 AC023128.2 CTA-276O3.4RP11-399E6.1 RPL36AP15 DNM1P51 RP4-764D2.1 GS1-600G8.5 EPN2-AS1RP4-641G12.4 AC005808.3 AC010149.4 KATNBL1P3 SUMO2P10 RP11-342M3.5MTATP6P17 DPY19L2P4 XXbac- RP5-928E24.2 AC006946.15 AC114755.7B476C20.14 LINC01221 RP11-693N9.2 LLPHP2 AC009505.2 MSC-AS1 LINC00402RP11-230B22.1 AC087499.5 SUMO1P4 NOP56P1 AP000477.2 RP3-412A9.12AC073150.6 RP11-448G4.2 LINC00494 AC016644.1 LINC00484 LINC00298RP11-109P14.8 AC018442.1 RP11-395P16.1 CYCSP52 ANKRD34C MFRP AC013268.3AC007349.5 TRIM60P19 PHACTR2-AS1 BRD7P5 DPYD-AS2 AC079779.5 ZNRF3-IT1HCFC1-AS1 MYL6P2 ADAM21P1 RP5-1022P6.5 LINC00837 TBCAP2 BHLHE40-AS1CNN2P3 AC124944.4 HS6ST2-AS1 OR7E145P RP11-338C15.5 RP1-102G20.4ARHGEF7-AS2 RP11-59O6.3 AC023115.2 TSPEAR-AS1 RP11-460E7.8 MTCO2P11NEXN-AS1 RP11-250H24.6 AC007405.8 AC008280.1 AC002543.2 EGOTRP11-472G23.10 VN2R19P AC007050.17 AC105921.5 HIGD1AP12 RP11-160E2.16PATE3 RP11-323C15.2 RP11-90O23.1 AC019117.2 CHIAP1 FABP5P2 AC073410.1GAPDHP14 HSPB1P1 RP5-101101.3 HMGN2P28 BNIP3P2 RP11-630I5.1 DUX4L26RP11-65J3.6 RP11-231P20.2 PRADC1P1 GAPDHP57 RP1-182D15.2 SSU72P6RP11-163G10.4 RP11-297K7.1 PRKX-AS1 RP11-105N14.3 LINC01376 PPP1R11P1RP11-645N11.3 VEZF1P1 AC017048.2 MTCYBP24 RP11-15J10.8 DIAPH2-AS1AC017083.2 LINC01361 RP4-728D4.3 CLEC2L AC114737.3 AC013463.2 NPM1P8EEF1GP7 RP11-340I6.7 TLX1NB OR7E109P RP11-348H3.5 AC019117.1 SLFN14AC005300.5 RP3-486I3.5 RP11-759F5.1 PPIAL4G FMR1-IT1 RP5-1103B4.3AC079584.2 RP11-334A14.2 RP11-440G9.1 POU5F1P5 AC084809.3 RP11-320G24.1RP11-447M12.2 RP11-132N15.2 AC090018.1 RP11-79M19.2 RP11-107M16.2RP11-296A18.6 UBE2L5P ATG10-IT1 AC067956.1 AC130689.5 LINC00427RP11-104D3.2 AC007040.8 RP11-89N17.4 RP3-336K20_B.2 KLF2P4 NPM1P40AC007278.2 RP1-125I3.2 AC097711.1 H3F3BP1 RC3H1-IT1 RP1-118J21.5AC079807.3 RP11-243J16.7 YWHAQP5 RAD23BP1 SNRPGP14 RP4-669L17.2 EEF1DP8IFNA4 CTA-221G9.7 DLX2-AS1 RP11-108L7.4 AC104076.2 RP11-85O21.2RP11-296P7.4 BZW1P1 LINC01010 SMAD9-IT1 RP11-359I18.1 RP11-411K7.1RP5-1184F4.5 RP11-365O16.1 AC078941.1 BCRP8 RP11-383C6.2 RPS3AP12ANKRD20A7P LINC01563 AC091633.2 RP11-239E10.2 LINC01474 AC105393.1RPL23AP23 RP11-44H4.1 RP3-522J7.5 AP001615.9 RPS20P5 XXbac- ASS1P7RP11-128B16.3 RP5-1063M23.2 RP4-651E10.4 RP11-792A8.1 B476C20.11RP3-329E20.2 AC003092.2 RP11-98D18.7 RP11-366M4.8 ZDHHC20-IT1 LINC01141OR52N3P GAPDHP51 ANKRD44-IT1 LINC00614 RP11-544A12.4 YBX1P9 KRT18P52RPL21P33 RP1-315G1.1 RP11-16C18.3 RPL34P1 AC097374.3 RP13-436F16.1RP4-550H1.5 RPL5P2 RP11-168K11.2 EHMT2-AS1 RP11-73E6.2 RP11-342M1.6AC018890.4 TAAR9 RP1-131F15.2 CYP2F2P LINC01056 HAND2-AS1 MRPS6P2DDX10P1 DNAJC19P1 MCFD2P1 RP11-443F16.1 RPL12P27 RPS7P15 AC019080.1RP11-229A12.2 NR2F1-AS1 DLGAP5P1 ZBTB40-IT1 IMPDH1P4 SETP4 RP11-322A17.1TRBV30 MTND2P8 RP4-568F9.3 AC073069.2 AC068492.1 OR51R1P RSL24D1P8RP11-96C23.9 CKMT1B HIGD1AP8 RP4-809F4.1 AP000563.2 RP11-201O14.1 RNF223XIAP-AS1 SYP-AS1 AC004461.4 RP5-1065J22.2 PATE4 RP11-509J21.2RP11-334N17.1 BRWD1-IT1 RPL21P121 RP11-165J3.5 RP11-402L1.4RP11-139I14.2 CAMTA1-IT1 RP11-226L15.1 AP001092.4 XRCC6P1 AC069257.6RP11-305L7.3 RPSAP2 RP1-159A19.4 RP11-15P13.1 RP1-127L4.10 CDC27P2RPL23AP71 CDK2AP2P2 RP11-554F20.1 AP000361.2 RPL7P53 XXbac-RP13-926M18.1 B135H6.15 OR2L9P PKN2-AS1 MTCO3P17 AC096775.2 PYY2 GCSHP3RP11-383J24.2 RP11-20J15.2 IGKV1OR10-1 AF064858.10 OR9A1P MTCO2P19FRY-AS1 HMGB3P5 HLCS-IT1 RNASEH2CP1 KRR1P1 RPL30P4 RP11-360O19.4 IRGMAP004289.2 AC008937.2 EEF1A1P28 P4HA2-AS1 DCTN1-AS1 NPAP1P3 AC002368.4RP3-423B22.5 AC092620.3 RP11-129B9.1 DDR1-AS1 RP11-54A4.2 GFOD1-AS1AC010894.5 CICP11 HNRNPA1P39 RP11-400K9.4 RPS3AP29 RPL23AP33RP11-332O19.2 RP11-432N13.2 RP1-67K17.4 RP4-630A11.3 AC097533.1 POU5F1P4LINC00398 NALT1 RPL23AP32 KLF7-IT1 RP3-393E18.2 AC097523.3 Z95114.5PPIL1P1 AC013267.1 TMEM161BP1 RP11-231N9.1 FLG-AS1 NPAP1P6 COX6CP10RP4-641G12.3 ZDHHC4P1 AF011889.2 RP1-128O3.6 MRPL48P1 PPP1R26P1AC006195.2 LINC01625 AC066692.3 LINC01589 SLC9A3P2 BRWD1-AS1 LINC01053RPS2P35 AC017079.4 RP11-656D10.6 RP5-875H3.2 RP11-69L16.4 GS1-309P15.4HMGN2P17 AC067940.1 RP11-402L1.12 LINC00707 RP3-436N22.3 AC012360.6HOMER2P2 RP11-100G15.4 RP11-431K24.1 RN7SKP198 SNORA81 SNORD97RP11-23D24.2 RNU1-13P SNORA47 RP11-536C10.1 RPL21P106 GAPDHP39 RPL27P12RPS20P22 RN7SL546P RN7SL589P RPSAP4 RN7SL184P RP11-400L8.2 RP11-492E3.51RP11-407P2.1 PCDHA13 CTD-2301A4.1 RP11-101K23.1 CYP4F62P RP11-330L19.2RN7SL569P RPL7P38 KLHL41 RPS3AP41 RP11-163E9.1 RPS4XP18 MARK2P8PLCH1-AS1 RPL9P5 POM121L7 RPS14P8 RP11-9D8.1 GOLGA2P2Y RP11-109N23.1RN7SL12P SETP11 RN7SL388P OR1J4 RP11-449H3.1 RUVBL1-AS1 HMGN1P7RP11-543D10.2 MTND1P3 MYADML RPL9P31 RP4-803A2.2 CTD-3193K9.1RP11-665C16.1 RP3-461F17.1 RP11-6F2.3 RN7SL692P RN7SL688P RN7SL672PRP11-496B10.3 ITIH4-AS1 DENND6A-AS1 RN7SL213P RN7SL754P RP11-767L7.1RPL23AP72 IGKV1-6 RN7SL225P IGKV1-37 RN7SL34P RN7SL674P RN7SL530PRPS10P16 AC015691.13 LINC01471 AP001625.4 RP11-246A10.1 ENPP7P2 YBX1P3RPL7P24 RP11-561B11.1 OR9A3P RPS3AP32 RPL9P30 BMS1P3 RP11-641C17.4RN7SL146P FABP5P11 RP11-204K16.1 RP11-758P17.3 CPHL1P RPS27P29 RN7SL587PRN7SL794P B4GALT4-AS1 RN7SL717P RN7SL100P RP11-841C19.1 RP11-331F4.4AC017002.1 RPL36AP45 VPS26AP1 CTD-2061E19.1 RPL9P3 KIR3DL2 RPS26P34RP11-95I19.1 RN7SL472P RN7SL116P RPL29P2 RN7SL277P UOX RP5-1061H20.3RPL21P123 CTD-2313F11.1 RPL3P9 RP1-184J9.2 AC010153.3 RP11-20L24.1RN7SL258P RN7SL403P C1QTNF9 RP11-174O3.3 RP11-555K12.2 AC006539.2 MYL6P4PNMA2 RPS2P39 RP11-430C7.4 RPS4XP15 KRBOX1 ERLEC1P1 AC098831.4 RN7SL288PRP11-435F17.1 AC073934.6 MTND4LP7 CTD-3236F5.1 AC093627.10 RP11-572F4.1IGKV1-16 RP11-65E22.2 RN7SL209P RP11-372E1.1 HOXA11-AS CTD-2036J7.1RPL29P24 RN7SL709P RP11-689J19.1 RPL7P43 RPL17P40 RPL17P44 FLJ46066PRICKLE2-AS1 RPL22P19 LINC00881 ARHGAP31-AS1 RP4-752I6.1 RP11-106J23.1TDGF1 RN7SL165P SNAPC5P1 RP11-572M11.1 MTND4LP17 RN7SL443P RN7SL801PRP11-275H4.1 AC093620.5 ENPP7P4 RP11-221J22.2 RPL34P33 WDR82P2 SETP6RN7SL385P PMS2P11 RP11-758P17.2 RPL36AP43 HNF1A-AS1 RP11-192C21.1FAM195CP RN7SL505P EEF1A1P25 RPL37P6 CTD-2224J9.4 TDGF1P6 RPL7P19RN7SL182P LINC00635 PTPRG-AS1 RP11-85G20.2 CA15P1 RN7SL767PRP11-624D20.1 ZBTB20-AS1 IGKV2D-24 RN7SL338P PAQR9-AS1 ATP5A1P7PRICKLE2-AS1 RPL23AP8 RN7SL482P RP11-520D19.2 CTD-2007H13.1 KRTAP5-4RP11-34P13.9 RP13-585F24.1 UGT1A1 RPS23P6 INMT RN7SL253P RPS27P12RP11-732A19.1 RN7SL704P RN7SL265P VWFP1 ZNF90P1 XACT RP11-555M1.3RN7SL438P RN7SL390P ENO1P4 RP11-1000B6.2 RPL7P42 RN7SL434P RN7SL363PKLF3P2 RP11-85I21.1 RP11-292E2.2 HOGA1 RN7SL517P HNRNPA1P24 CTC-340A15.2RN7SL76P RN7SL566P RN7SL323P RP11-338L18.1 ALG1L15P RN7SL68PRP11-1396O13.1 RP11-70F11.2 RP11-690C23.2 DNAJB8-AS1 RPS3AP49CTD-2555K7.1 MARK2P6 TOPORSLP1 SERBP1P3 ABCF2P1 ARHGDIG RN7SL127PRP11-568K15.1 RN7SL594P RN7SL306P RN7SL57P LINC00996 RP11-659G9.1RP11-197K3.1 RPL12P32 RP11-875H7.5 CTD-2184D3.1 RN7SL683P RPL6P9RP4-631H13.2 RN7SL800P RP11-267J23.1 C3orf67-AS1 RP11-731J8.1 UPK3BP1RPS15AP32 RN7SL500P RP11-270M14.1 RP3-477O4.5 NDUFB4P1 KLHL6-AS1OR7E100P MRPL42P4 RN7SL144P RPL21P11 RP11-469J4.3 CSAG4 CTD-2339M3.1RPS3AP34 CTC-359D24.3 RPS24P16 RP11-271C24.2 RP11-745A24.2 RN7SL40PCCT4P1 CTD-2015H6.2 RN7SL362P RN7SL806P RP11-562A8.1 RP11-30K9.1 RHOT1P3RN7SL824P IGKV1D-17 RP11-651P23.5 RP11-436H11.1 RPS26P21 KRT8P35RN7SL749P CTC-484M2.1 RP11-190P13.2 RPL5P11 RN7SL413P RP11-298O21.6RPL12P7 EPS15P1 RPSAP3 FTH1P23 RP11-446F17.3 RPL7P40 FTH1P4RP11-697H10.1 RN7SL239P RN7SL16P RPL12P35 RP11-556N21.1 PTMAP8 MARK3P3RN7SL354P GAPDHP47 RP11-58E21.1 RBMY2FP RPL31P58 RN7SL842P RP11-613M5.2LINC00870 RPS3P7 RN7SL452P RN7SL22P RP11-115N4.1 RP11-734J24.1HNRNPA1P17 RP11-286H14.8 AC073130.3 RN7SL350P RN7SL558P RN7SL614PCTGLF9P RPL31P61 RP11-268I9.1 POM121L6P RP11-397E7.1 RN7SL285PRP11-538P18.1 FGF14-IT1 RN7SL174P RN7SL307P RP11-445N18.7 RP11-57G22.1RN7SL775P CTD-2110K23.1 AC012442.5 RP11-454H13.1 RP11-473O4.1RP11-330L19.1 RPL35AP32 RP11-245J9.4 RPL23AP49 RP5-837J1.1 AF165138.7RP11-715J22.1 RPS18P13 INGX RPL7P51 RP11-572M11.2 RN7SL337PRP11-521D12.5 UBA52P5 RPS6P21 RPS23P1 RP11-775J23.2 RP11-627K11.1IGLVIVOR22-2 RN7SL19P CTC-458A3.1 RN7SL649P RN7SL364P RN7SL838P UPK3BRP11-2I17.1 RP11-14I2.2 RPL35AP26 RPS2P44 RP11-281P11.1 RP11-215P8.1RP11-4K3_A.3 WBP1LP1 RPS4XP14 RPS3AP40 OR7E66P RP11-379F4.1 RN7SL598PRN7SL638P RN7SL105P RPL23AP63 RPLP0P2 CTD-3131K8.1 RP11-864G5.1RP11-112N19.1 OR7E89P RP11-390K5.1 RN7SL610P RN7SL67P RN7SL487PRN7SL419P RN7SL320P ELFN2 RPSAP5 RN7SL430P RPS12P21 RN7SL743P RN7SL684PRP11-473P24.2 RPS24P17 RN7SL447P RP1-300I2.2 RP11-1396O13.2 B3GAT3P1RPL35P6 RP11-266K4.1 RPL5P24 RP11-389C8.1 MARK2P17 GSTA2 RN7SL833PRPSAP51 RP11-757F18.3 RP11-1070A24.1 RP11-810P12.1 RP11-114H7.1RP11-379K17.5 FOXP1-AS1 PDZK1P1 ZFAND6P1 RPS4XP10 LINC01330 RPL26P35RN7SL698P GMCL1P1 IFITM10 RP11-139K4.2 RP11-64K12.1 RN7SL168P RN7SL395PRN7SL36P RN7SL845P CTB-47B8.1 RP11-119K6.6 RP11-654C22.2 RP11-531F16.3LY6G6D RN7SL145P RN7SL330P RP11-428G5.1 IGKV3-15 RP11-354H21.1RP11-206M11.7 ERVFRD-1 OR2A1-AS1 RP11-278L15.6 LINC01391 WNT5A-AS1RP11-713H12.1 RN7SL334P RP11-241J12.1 RN7SL863P XKRY2 RN7SL280P RPL10AP1CTAGE8 PTCHD4 RP11-133K1.1 RN7SL47P ASLP1 RP13-1056D16.2 RP11-373E16.3RN7SL153P ALKBH3-AS1 RP11-529F4.1 CTD-3064M3.4 RP11-744N12.3RP11-286E11.1 ARNTL2-AS1 KB-1471A8.1 AC004053.1 RP11-847H18.2RP11-620J15.2 MIR4300HG CEBPA GS1-24F4.2 LINC01513 ALDH1L1-AS2RP11-260E18.1 RP11-77I22.2 RP11-13A1.1 RP11-386I8.6 LINC00968RP11-7F17.5 RP11-1094H24.4 LINC00535 RASSF8-AS1 RGMB-AS1 SOCS2-AS1RP11-700H6.1 CTC-338M12.7 RP11-588G21.2 LINC01498 RP11-273G15.2CTD-2235C13.2 RP11-392P7.6 MIR4458HG CTB-127C13.1 RP3-510L9.1RP11-543C4.1 RP11-422N16.3 DPH6-AS1 INSL3 RP11-709A23.1 CTC-338M12.9SMURF2P1 CTD-2012J19.2 RP11-472K22.1 GAPDHP60 ATG10-AS1 RP11-153M7.1KCTD9P5 CTD-2139B15.2 RP11-366M4.12 AC037459.4 CTB-49A3.2 CTC-499J9.1CTD-2194F4.2 TNXA DDX43P1 CTD-2308B18.3 RP11-717H13.1 RP11-293A21.2LINC00504 RP11-501M7.1 FOSL1P1 RP11-503N18.4 RP11-576N17.3 PRR5-ARHGAP8KB-1269D1.8 GAPDHP61 RP11-1191J2.4 RP11-284A20.3 RP11-321E2.3RP4-598P13.1 CTD-2207A17.1 RP11-640B6.1 DDX11L9 CTC-338M12.2 ZFAT-AS1LNX1-AS2 RP11-145G20.1 CTC-338M12.1 RP11-265O12.1 RP11-174F8.1RP11-10A14.5 RP11-241F15.1 RP11-90P5.1 CTD-2516K3.3 RP11-158I23.1RP11-366M4.6 RP11-302F12.5 LINC00992 TOX4P1 CTC-493L21.2 RP11-377G16.2CTC-236F12.4 NMNAT1P4 ACTN3 CTC-276P9.2 RP11-974F13.5 LINC01095 ZNF807CTB-17911.2 RP11-227H4.5 CTD-2016O11.1 TNFSF12-TNFSF13 CTC-537E7.3RP11-950K24.2 FAM138E RP11-72K17.2 HMGB1P44 BCLAF1P1 CTD-2256P15.1CTD-2113L7.1 RP11-395I6.1 LAMTOR3P2 RP11-87F15.2 RP11-815N9.2RP11-317B7.2 CTNNAP1 SUMO2P6 CTB-113P19.1 COX6B1P5 TBCAP3 RP11-326I11.1RP11-72L22.1 KRT18P25 PCNAP1 LINC01033 WSPAR RP11-478C1.8 C5orf66-AS1AC051649.12 RP11-381N20.2 CTB-35F21.2 SLED1 PRDX2P3 CTD-2290P7.1AC006445.7 RP11-1C1.5 RP11-1C1.6 RP11-304F15.5 CTC-506B8.1 CTD-3080P12.3AC138517.4 ATP5L2 CDH12P2 RP11-452J21.2 BCL9P1 RP11-557J10.3 PGAM1P8RP11-468H14.2 MTHFD2P6 UNC93B8 CTC-436P18.3 ACTR3BP4 FTH1P24 AC010468.2ATP6V1G1P6 RP11-834C11.6 RP11-1C1.4 HMGB3P17 CTD-2234B20.1 RP11-317O24.1IL20RB-AS1 RP11-391J13.1 CTC-563A5.2 RP11-438D8.2 CFAP99 CTD-2224J9.7KRT18P45 LINC01091 CTB-49A3.5 LINC01470 GAPDHP70 EGFLAM-AS1 ZEB2P1LINC01438 RP11-642E20.3 RP11-789L4.1 HSPD1P15 AC226118.1 CLRN2CTB-46B19.2 RP11-703G6.1 OR52V1P RP11-710F7.3 HOXC13-AS RP11-552M14.1OR7E94P C5orf66-AS2 VN1R104P TNRC18P1 CTD-2227C6.2 MIR143HG RP11-217C7.1TUBA3GP KRT19P3 RP11-1336O20.2 RP11-598F7.4 RP11-217E13.1 RP11-60A8.1RP11-563M4.1 RP11-447H19.3 SCARNA22 CTC-428G20.2 PGBD4P3 GAPDHP76RP11-166J22.1 HS3ST5 RP11-983C2.2 CTB-57H20.1 RP11-434D9.2 RP5-1029K10.2LINC01265 CTD-2280E9.1 XXbac- UQCRBP3 CCDC79 B444P24.8 YWHAQP6 TMEM158RP11-814P5.1 RP11-584P21.4 RAF1P1 CTD-2003C8.2 CBX3P3 RP11-148B6.2RARRES2P4 RP11-576N17.5 CACNA1G-AS1 AC107982.4 RP11-553P9.1 MORF4L2P1CTC-498M16.2 RP11-268P4.5 CTC-321K16.1 HMGN1P15 RP13-577H12.3RP11-397E7.2 SEPT14P9 CIR1P2 RP11-9G1.3 SEPHS2P1 LINC01612 RP11-122A21.2RP11-94C24.8 NCAPGP1 ZBED1P1 RP11-44F21.4 MGC32805 KDELC1P1 LINC01340CTD-2272G21.2 RP11-503L19.1 AC008592.5 RP11-22A3.2 TRIM75P CTC-467M3.3UNC93B4 RP11-395P13.4 KLHL2P1 RP11-448G15.1 CTC-461F20.1 SEC63P2 AACSP1KIAA1210 RP5-877J2.1 RP11-834C11.5 CLSTN2-AS1 TRIM36-IT1 DUTP7 ENPP7P9PPM1AP1 FLJ33360 RP11-640N11.2 ABT1P1 AC007126.1 AC008984.6 GPR162ABHD17AP3 RP11-254I22.1 KNOP1P5 RP11-215P8.4 LINC01511 RP11-39E3.3RP11-517I3.1 RP11-597D13.8 RP11-933H2.4 XXbac- RP11-295K3.1RP11-834C11.7 BPG32J3.19 HNRNPKP5 LINC01596 RP11-6L6.2 CTB-161M19.1KB-1042C11.1 RP11-392B6.1 RP11-366M4.14 C8orf17 RP11-404E16.1RP11-834C11.4 RP11-232L2.1 RP11-451H23.1 RP11-241F15.10 RP11-440I14.4AC138035.1 RP11-1084J3.3 RP5-1063M23.1 RP11-63A11.1 RP11-723O4.3RP11-531A21.4 DCAF13P2 RP11-91H12.4 HNRNPA3P13 RP11-11N5.1 HMGB1P29METTL21EP CTD-2281M20.1 RP11-588L15.2 RP11-632F7.3 CTB-161M19.2 LNX1-AS1ENPP7P11 RP11-402J6.3 AC073635.5 RP13-128O4.3 ORAOV1P1 RP11-159K7.1SLC25A30-AS1 RP11-629B11.4 HMMR-AS1 WBP1LP4 CTC-321K16.4 ZNF969PRP11-168A11.4 RP11-115D19.1 FCF1P8 RP11-701P16.2 RP11-701P16.3RP11-478C1.7 MTND5P5 HOXC-AS3 RP11-45L9.1 OR7E21P RP11-101E3.5RP11-689P11.3 LINC00589 RP1-68D18.2 RP11-54F2.1 RP11-400D2.2 CTC-278L1.1CTD-2187J20.1 RP11-889L3.4 RP11-1057B8.2 CNOT10-AS1 MIR3945HGRP11-540D14.8 RFPL4B RP11-340A13.2 RP11-400D2.3 RP11-506H20.1CTD-2337A12.1 RP11-317G22.2 AC006499.1 RP11-461G12.2 HSPD1P11 MTND3P5RP11-697N18.1 RAB5CP2 AP000350.10 RP11-18H21.3 AC096582.9 RP11-484O2.1YTHDF1P1 RP1-240K6.3 LINC01256 FAM90A25P AC008592.4 CTC-369A16.2 RTEL1P1LINC01094 HAUS1P1 RP11-436H11.5 RP11-46A10.6 IMPA1P RP11-381N20.1CTD-2245E15.3 LINC00605 RP11-478C6.1 CTC-313D10.1 COQ10BP2 HMGB1P35LINC01267 NIFKP7 HADHAP1 RP11-673E1.1 RP11-610P16.1 AC009487.5RP11-826N14.4 UNC93B7 RP11-774D14.1 RP11-119D9.1 RP11-20I20.1 PRB1AC007036.5 RP11-614F17.2 RP11-631M6.3 RP11-181K12.2 RP11-478C6.5RP11-618I10.4 PTX4 ACA59 RNA5SP216 RN7SKP179 RNU4ATAC18P SCARNA17RNU2-27P SNORA31 RN7SKP265 YRNA SCARNA16 SNORA21 RN7SKP272 SCARNA6RN7SKP2 SCARNA1 SCARNA11 RN7SKP64 CTD-2373N4.5 IGLV2-34 RP11-459E5.1CTD-3023L14.2 CTC-436K13.2 RP11-589C21.2 CIR1P1 CTB-47B11.1RP11-279L11.1 CTC-209H22.3 RP11-152C15.1 RP11-1149M3.2 RP11-410L14.1HOXA10-AS AC084082.3 RP11-351A11.1 RP11-359P18.6 RP11-706C16.7RP11-546B8.3 PGAM5P1 NRBF2P4 IGHV3-76 C8orf88 RP11-10A14.6 IGKV2-14RP11-128L5.1 RP11-99A14.1 RP11-238K6.1 MIOXP1 RP11-779O18.1 CTB-160O22.1AC008703.1 SERPINE3 IGHVIII-76-1 RP11-61G23.2 RP11-497H16.8RP13-923O23.6 RP11-420B22.1 CTD-3023L14.3 KB-1460A1.2 RP11-90P5.2RP11-731F5.2 RP11-589F5.4 KB-1254G8.1 AC078852.2 RP11-231D20.2CTB-47B8.4 NCRNA00250 CDC42P5 AC133633.2 RP11-619L12.4 IGLV3-6 IGLV2-28CTD-2363C16.2 IGKV2OR22-3 IGKV1-35 RP11-110G21.2 RP11-1C8.4 IGHVII-26-2ATP6V1G1P2 CTA-398F10.1 RP1-170O19.14 RP11-417F21.2 XRCC6P4 AC106801.1CTD-2114J12.1 RP11-347C18.4 RP11-1174L13.2 RP11-402L5.1 PYDC2 CA3-AS1RP11-115C21.4 CTD-2340D6.2 KB-1184D12.1 RP11-723D22.2 IGHV3-30-2RN7SL260P RP11-369K17.1 AC144568.4 CTC-370J7.1 RP11-486M23.1 IGLVV-58LINCR-0001 CTD-2311A18.1 SOD1P3 NPM1P52 KB-1615E4.2 IGHVII-78-1KB-1410C5.2 CTC-348L5.1 RP11-567J20.2 KBTBD11-OT1 RP11-1259L22.1RP11-51J9.4 RP11-787D18.1 RP11-10N23.4 RP11-893F2.13 LZTS1-AS1 LINC01289RP11-779O18.3 KB-1460A1.3 MARK2P11 RP11-350F16.1 RP11-527N22.2 CYP4F44PRP11-21C4.4 RP11-439C15.4 HMGB1P23 LINC01030 CTD-2363C16.1RP11-1134I14.6 IGLV1-41 KB-173C10.2 RP11-96A1.5 KB-173C10.1 IGLVIV-66-1RP11-16P20.3 IGLVI-38 RP11-770E5.2 RP11-380I10.3 IGLV3-31 CTB-113P19.3IGLVIV-53 HIGD1AP18 CTB-43E15.1 RP11-363L24.3 CTB-178M22.2 LINC00051MAP2K1P1 RP11-10J21.3 BRIX1P1 CTC-436K13.4 RP11-328K2.1 RP11-172E10.1RP11-697N18.2 IGLVV-66 IGLV3-7 AC078852.1 AC005740.5 VENTXP6 RBPMS-AS1CTB-7E3.1 RP11-1007J8.1 RP11-661A12.4 RP11-359P18.5 IGKV2-18RP11-1149M10.1 AB015752.3 RP11-419L20.2 RP11-167P20.1 CTC-558O2.2KB-1043D8.6 RP11-11C20.1 FAM90A12P RP11-582J16.3 RP11-1080G15.2RP11-17A4.2 RP11-398H6.1 RP11-18A15.1 RP11-473O4.4 RP11-131N11.4RP11-382J24.2 RP11-6I2.3 IGHV3-32 CTB-17P3.4 IGLVIV-59 CTD-2045M21.1RP11-267M23.3 RP11-318K15.2 IGHVII-60-1 MAFA-AS1 RP11-10A14.3RP11-760H22.2 RP11-578O24.2 IGLVI-68 RP11-211C9.1 IGHV4-55 RP11-56F10.3RP11-578F21.2 RP11-179A10.1 RP11-215D10.1 RP11-182J1.1 SIGLEC14RP11-347E10.1 RP11-21L19.1 RP11-864G5.3 RP11-33I11.2 RP11-231N3.1RP11-718B12.5 RP11-304C12.3 HSPB2-C11orf52 OR7E11P ALG9-IT1RP11-867G23.4 RP11-867G23.13 PRKRIRP4 RP11-885L14.1 SLC25A1P1RP11-23F23.2 PTP4A2P2 CTA-797E19.1 KB-1073A2.1 AP000487.4 RANP3FBXO3-AS1 RP11-867G23.10 RP11-775A1.2 RP11-113K21.1 RP11-624D11.2RP11-463D19.1 NAV2-AS3 RP11-113D6.9 OMP RP11-196E1.3 MTND2P26 UBTFL9RP11-1007G5.2 RP5-1173A5.1 AP000662.4 RP11-22P4.2 RP11-700F16.2RP11-356J5.4 RP11-702F3.1 CTD-2560E9.3 STT3A-AS1 RP11-109L13.5RP11-265D17.2 RP11-354A14.1 COPS8P3 RP11-659G9.3 RP11-12D16.2RP11-565P22.6 RP11-35J10.4 RP1-145M24.1 RP11-560B16.5 RP11-351I24.3OR7E10P RP11-801G16.2 RP11-691N7.6 RP11-1H15.1 RP11-50B3.1 RP11-27P7.1AC084121.17 AC022182.1 GVINP2 FDPSP4 AC022182.3 RP11-672A2.4RP3-400B16.4 CTD-2530H12.2 SLC22A18AS AF131215.6 RP11-648O15.1RP11-203M5.2 CTD-2523D13.2 RP11-867G23.1 RP11-113D6.3 RP11-945A11.2CTD-2516F10.4 PTPRJ-AS1 NAV2-AS1 RP11-482L11.1 RP11-513D5.2RP11-263C24.3 RP5-1160K1.8 INMT-FAM188B RP11-1081L13.4 RP11-65M17.3RP11-167J8.3 RP11-429J17.7 RP11-702H23.2 ALG1L9P FTLP6 CTD-2509G16.2RP1-68D18.3 AP000442.4 RP11-113K21.3 ARL6IP1P3 RP11-665E10.1RP11-45A12.2 RP11-23J9.4 RP11-347H15.5 RP11-661A12.9 RP1-317E23.6RP11-263C24.1 RP11-843A23.1 AF186192.5 RP11-326C3.10 RP11-58K22.4RP11-794P6.2 RP11-406D1.2 TBC1D26 RP11-159H10.1 AP006621.8 RP11-91P24.3RP11-655M14.12 OVOL1-AS1 RP11-685M7.5 GLTPP1 HNRNPA1P76 CTD-2313N18.8HSPE1P18 AP002954.3 RP11-720D4.3 NANOGP8 RP11-945A11.1 RP4-541C22.5RP11-794P6.3 OR5M11 RP11-304M2.3 RP11-438N5.4 CTD-2655K5.1 CTD-2523D13.1PPP1R1AP1 CTD-322413.3 RP11-430H10.2 RP11-702F3.4 RRM1-AS1 ABCC6P2RP11-91I20.1 RP11-757C15.4 RP11-655C2.3 RP11-624G17.3 RP5-901A4.1 OR52B2RP11-428C19.4 RP11-160H12.2 RP11-91I20.4 CTD-2530H12.4 RP11-484D2.5RP11-299M14.2 CTD-233717.1 NOX5 RP11-700F16.3 RP11-382M14.1 CCDC179RP11-412B14.2 RP11-619A14.3 RP11-672A2.5 RP11-1134I14.8 RP13-726E6.2DUXAP5 CTD-2028E8.1 C8orf49 HCAR3 RP11-770G2.5 PCDHA3 CASC23CTD-2011F17.2 AP002954.4 CTD-2530H12.8 RP11-510I21.1 RP11-632K5.2CTD-2210P24.6 SEPT14P8 RP11-113D6.6 RP11-998D10.1 RP11-687M24.4RP11-1H15.2 RP11-867O8.5 RP11-65M17.1 CTD-2381F24.1 RP11-347H15.2AC005363.9 RP11-164N3.1 RP11-390K5.3 RP11-780O24.2 OR10V2P CTA-797E19.2RP11-727A23.8 RP11-627G23.1 RP11-770G2.2 UNC93B6 RP11-273B20.3AP000462.2 RP11-377D9.3 FAM222A-AS1 RP11-885B4.2 RP1-127H14.3 APOOP3RP11-46H11.2 RP11-529H2.2 RP11-283G6.5 RP11-22B23.2 LINC01479 RMST OR6J1RP5-1154L15.1 RP4-559A3.7 RP11-338K17.8 Metazoa_SRP RP11-612B6.1AC073610.5 CTD-2102P23.1 RP11-286N22.10 RP11-351O2.1 AP003419.16RP11-656E20.5 RP11-69M1.3 RP11-513G19.1 PSMC1P9 RP11-20D14.4 AC084117.3TAS2R63P TCEB1P31 RP11-190A12.7 PAPPA-AS1 RP11-982M15.6 RP11-709A23.2RP11-81H14.3 AP000721.4 RP13-672B3.5 LINC01152 RP5-944M2.4 EGLN3P1RP11-968O1.5 RP11-76C10.5 RP11-820K3.4 SMLR1 RP11-627K11.3 TSPAN9-IT1RP11-439H13.2 AC005255.3 RP11-1018J11.1 RP11-1038A11.2 RP11-771K4.1RPL7AP3 RP11-989F5.1 RP11-504G3.4 METTL8P1 RP11-338E21.3 ABCC6P1RP11-21A7A.3 RP1-7G5.5 NTAN1P3 RP11-349I1.2 RP11-173P15.3 RP11-428G5.4PPIAL4D RP11-1060J15.4 RP11-500M8.4 RP1-102E24.8 RP11-794G24.1RP11-809N8.4 RP11-363J17.1 RP11-428G5.6 RP11-860B13.3 RP11-212D19.5RP11-598F7.6 NANOGNBP2 ENPP7P5 CYP2B7P RP11-815J4.6 MTRNR2L1RP11-76I14.1 RP11-144023.8 RP11-218M22.2 RP11-599J14.2 RP11-444B24.2RP11-785H5.2 PGA5 CACNA1C-IT3 RP11-613F22.7 RP11-45F15.1 RP11-17G12.3RP11-234B24.5 STH RP11-503G7.1 RP13-977J11.5 RP11-76C10.2 RP11-158L12.5TPT1P12 AC138744.2 GS1-410F4.5 RP11-467L13.4 CCND2P1 RP11-664D1.1RP11-503G7.2 IQSEC3P1 RP11-817J15.2 RP11-598F7.3 RP11-6B19.2 LIMS3RP11-972L6.2 RP11-351O2.2 RP11-800A3.7 RP11-137N23.1 RP11-783K16.10RP11-667M19.4 RPL29P33 RPEP6 AE000658.22 CLIP1-AS1 LRRC37A13PRP11-259O18.4 OR4F28P RP11-129B9.2 RP11-320P7.2 RP11-813P10.1CTD-2213F21.3 RP11-58A17.3 RP11-754I20.3 RP11-611O2.5 HNRNPA1P50FAM205BP RP11-54A9.1 RP11-136F16.2 RP11-611E13.3 RP3-405J10.4RP11-767I20.1 RP11-434H14.1 RP11-190J23.1 RP11-557F20.2 RP11-496I2.2RP11-511B23.2 RP11-478B9.3 MGAM RP11-616L12.4 BNIP3P6 RP11-780K2.1RP11-74K11.1 RP11-328C8.2 RP11-644F5.12 RP11-56G10.2 RP11-2H8.2RP11-603J24.9 RP11-263K4.3 RP1-71H24.1 RP11-290L1.3 RP11-159D23.2RP11-359M6.1 RP11-983P16.2 MRPL2P1 RP3-521E19.2 RP11-956E11.1 NPIPB1PRP11-20E24.1 RP3-405J10.2 RP11-144F15.1 RP11-44N21.1 RP11-863H1.1GSTP1P1 RP11-44N21.4 RP1-128M12.3 RP11-570L15.2 RP11-278C7.2RP11-579D7.2 CBX3P5 RP11-76E16.2 RP11-175P13.2 ILF2P2 MGAM2RP11-536C10.21 RP11-186F10.2 OR5BK1P RP11-1143G9.4 RP11-162P23.2CTB-193M12.1 RP11-2H8.4 RP11-46I1.2 RP11-616L12.1 RP11-263K4.1RP11-769N19.2 RP3-432I18.1 RP11-493L12.5 RP11-493L12.3 RP11-46I1.1RP11-620J15.1 RP1-228P16.5 RP1-228P16.4 RP11-61E11.2 RP11-603K19.1RP11-406H4.1 Metazoa_SRP CTD-2021H9.3 RP11-474P2.2 RP11-753H16.3RP11-18O15.1 RP11-1105G2.4 RP11-394J1.2 NKX2-2-AS1 ZNF75BP RP11-654D12.2CLEC5A RP1-46F2.3 RP11-219B4.5 RP11-570L15.1 RP11-887P2.5 POLR2KP1TESC-AS1 BRWD1P2 NUTF2P2 RP11-690J15.1 CTD-2314B22.1 KLF17P1RP1-267L14.3 RP11-161H23.9 RP11-115H15.2 RP11-536G4.2 RP11-603J24.6RP11-651L5.2 SLC25A3P2 RP11-1070N10.4 RP11-831F12.2 RP11-326E7.1 NT5CP2RP11-665C16.6 RP11-711D18.2 RP11-661G16.1 RP11-109N23.5 RP11-903H12.3RP11-361H10.3 SPESP1 SRMP2 ZFP64P1 DIO3OS CTD-2062F14.2 EIF3LP1RP5-892G5.2 RP11-638I2.9 RP11-16B13.1 RP11-159L20.2 CTD-2376120.1CTD-2313J17.3 BLZF2P DUX4L16 RP11-320M16.2 FAM181A-AS1 NBEAP1CTD-3051D23.4 SERPINA2 LINC-ROR COX7A2P1 RP11-492D6.3 RP11-354B3.1RP11-857B24.1 RPL21P5 LINC00930 RP11-509A17.3 RP11-517O13.3 RP11-638I2.8RP11-407N17.2 RP11-74M13.4 LINC01269 RP11-1033H12.1 RP11-433J8.1LINC01193 CKAP2P1 RP11-404P21.6 RP11-603B24.1 LINC00637 RP11-982M15.7RP11-862G15.1 RP11-80A15.1 RP11-688G15.3 RP11-841O20.2 RP11-613G13.1DIO2-AS1 NANOGP7 BMS1P15 KRT18P6 RP11-404P21.9 CTD-2302E22.2 RP11-7F17.3CTD-2555K7.3 CTD-2566J3.1 RP11-355I22.5 RP11-286O18.1 RP11-945F5.1RP11-894P9.2 RP11-463J10.4 CTC-554D6.1 LINC01146 EIF4EBP1P1 FDPSP3RP11-270M14.5 HIGD1AP17 RP11-193F5.1 SCOCP1 RP11-260M19.2 BHLHB9P1NPM1P5 RP11-47I22.1 RP11-463J10.2 RP11-1078H9.2 RP11-255G12.2RP11-857B24.5 SALRNA1 RP11-747H7.1 RP11-829H16.5 RP11-934B9.3 LINC01467COX5AP2 RP11-125H8.1 RP11-368P15.2 RP11-398E10.1 DOCK11P1 RP11-671J11.7RP11-8L8.2 RP3-449M8.6 RP11-973N13.2 RP11-561B11.6 DNAJC8P1RP11-810K23.6 DUX4L18 CTD-2062F14.3 RP11-409I10.2 AE000661.50CTD-2058B24.2 AE000662.93 RP11-1140I5.1 PEBP1P1 RP11-386M24.5RP1-261D10.1 RP11-488C13.6 SEPT7P1 TRAV30 RP11-348M3.2 RP11-270M14.4RP4-687K1.2 LINC00924 CTD-2240H23.2 RP1-261D10.2 DUX4L17 CTD-2017C7.3RP11-463C8.4 RP11-154B12.3 UBE2CP4 RP11-424I19.2 RP11-253M7.3RP11-133K1.6 RP11-209K10.2 CTD-2071N1.1 LINC00928 CTD-3076O17.2 SLC35G6HNRNPA1P62 CTD-2555C10.3 RP11-349G13.1 GOLGA8VP RP11-361D15.2RP11-521C20.1 RP11-313P18.2 AC002306.1 TTTY25P RP11-616M17.1RP11-325L12.3 NDUFA3P4 AC007950.1 ANKRD62P1 CTD-2501E16.2 RP11-122D10.1RP11-355N15.1 CTA-339C12.1 RP11-37J13.1 PLCB2-AS1 RP11-561C5.7 OR11K1PLINC00596 HNRNPMP1 RP11-323I15.5 TGIF1P1 RP11-349G13.2 RP11-798K3.2RP11-111E14.1 RP11-90E5.1 RP11-307C19.1 RP11-64K12.9 RP11-815J21.4CTD-2240J17.1 RP11-815J21.2 RP11-505E24.3 RP11-605F22.1 RP11-313H3.1RP11-430B1.1 RP11-30K9.4 ISCA1P4 HERC2P7 RP11-7M10.2 RP11-158M2.5HNRNPCP3 RP11-593F23.1 RP11-35O15.1 CTD-2651B20.4 NPM1P43 RP11-403B2.5RP11-736N17.8 NIFKP8 RP11-815J21.1 CPEB1-AS1 RP11-540O11.7 AHCYP7NDUFAF4P1 RP11-621H8.2 RP11-19J5.1 RP11-244F12.3 RP11-616K22.2RP11-74D7.1 RP11-661D19.3 UBE2Q2L CYCSP38 RP11-685G9.2 CTD-2651B20.3RP11-540O11.4 RP11-272D12.2 RP11-325E5.4 CYCSP2 RP11-335K5.2CTD-2329K10.1 KRT8P23 RBM17P4 RP11-317G6.1 RP11-429B14.3 RP11-540O11.6RP11-562A8.5 RP11-597K23.1 RP11-467H10.2 RP11-557C18.4 PCAT29RP11-351M8.1 RP11-89K11.1 LINGO1-AS1 RP11-485O10.2 RP11-702L15.4RP11-139F4.2 RP11-499F3.2 RP11-485O10.3 RP11-227D13.1 RP11-752G15.4NUTF2P6 CTD-3032H12.1 CSPG4P11 RP11-356M20.3 AC066615.1 RP11-158M2.4RP11-90B9.2 RP11-182J1.13 RP11-1006G14.2 RP11-20I23.3 RP11-359K18.3RP11-554A11.9 LYPD8 RP11-63E9.1 LINC00567 HERC2P10 RP11-467L24.1AC097374.2 RP11-177N22.2 RP11-1012E15.2 RP11-293B20.2 RP11-1H8.4RP11-343C2.7 RP6-91H8.2 CTC-527H23.2 AC022819.3 RP11-322D14.1RP11-218M11.1 CTD-2323K18.2 CTD-2651B20.7 RP11-48G14.2 CTD-2012K14.3RP11-170L3.4 AC009133.15 CTD-2547G23.2 RP11-652G5.1 RP11-2E17.2 CDC37P1RP11-252K23.1 TGFBR3L RP11-65J21.1 RP11-1035H13.2 RP11-480I12.10CTC-527H23.1 CTD-2651B20.6 CTC-527H23.3 GOLGA2P11 RP11-182J23.1CTD-2313J23.1 RP11-254F7.2 RP11-615I2.1 RP11-92G12.3 RP11-77K12.7LINC01070 AOC4P RP11-883G10.1 RP11-177B4.2 LA16C-312E8.2 RP11-258F22.2CSPG4P13 RP11-322D14.2 RP11-748L13.6 CH17-53B9.2 CTC-471J1.2 MTCYBP28RP11-95H11.1 LINC01413 RP11-2I17.4 CTD-2022H16.3 RP11-432I5.6RP11-756H20.1 RP11-108B14.5 CTD-2026K11.2 RP11-680F20.10 RP13-395E19.2CCDC187 FRRS1L CTD-2026K11.3 RP11-588K22.2 RP11-46D6.4 EIF4EBP2P2C6orf229 RP11-973H7.1 RP11-386M24.6 RP11-152P23.2 DNM1P34 RP11-343C2.9AQP4-AS1 RP11-540B6.2 WBP11P1 RP11-1129I3.1 CTD-2649C14.1 RP11-800A3.4RP11-505K9.3 RP3-406A7.7 LA16c-444G7.2 LINC01544 RP11-96D1.7RP11-304L19.2 NBAT1 KCNJ18 RP4-536B24.2 RP11-834C11.11 CTD-2196E14.9RP11-151H2.1 RP11-297C4.3 RP11-166B2.7 CTD-3193O13.1 AC004381.7RP11-368N21.1 CTD-2576F9.1 RP5-1085F17.4 CTB-134F13.1 MT1L RP11-457I16.2RP11-63M22.1 RP11-403N16.3 TPST2P1 CTA-363E6.6 CTD-2055G21.1 DUX4RP1-140K8.5 RP3-522J7.6 RP11-1166P10.1 RP11-439L8.5 RP11-1299A16.3HERC2P5 RP1-178F10.1 RP11-315D16.4 RP11-368L12.1 RP11-69H7.2RP11-152L20.3 AC004158.3 RP11-744D14.1 RP11-278A23.2 CTD-2576D5.3RP11-546O6.4 RP11-146F11.4 RP11-513N24.1 RP11-744D14.2 VN1R67PRP11-165M1.2 RP11-329J18.3 VPS35P1 RP11-107F6.3 RP11-24M17.3RP11-319G9.3 RP11-256I9.2 RP11-403P17.5 RP11-615I2.3 CTA-331F8.1RP11-10K17.3 TAT-AS1 CKBP1 RP11-96D1.5 RP11-554A11.7 RP11-95M5.1AC008088.4 LINC00565 RP11-196G11.2 CTD-3154N5.1 SPCS2P1 RP11-476D10.1LINC00557 RP11-297L17.2 RP11-333I13.1 MKRN3-AS1 LA16c-395F10.2RP13-122B23.8 RP11-534L20.5 RP11-546B15.1 RP11-1437A8.5 RP11-116D2.1RP11-744K17.1 GS1-279B7.1 RP11-84D1.2 CTD-3247F14.2 AC012322.1CTD-2588J6.2 RP11-209D14.2 RP11-24M17.6 RP11-673P17.4 RP11-6O2.4RP11-7K24.3 RP11-554A11.8 RP11-5N19.3 RP11-435I10.3 RP11-96K14.1TMEM178B RP11-62H20.1 ADAMTS7P3 RP11-58A18.1 RP11-68I18.10 RP11-356C4.5RP11-844G16.1 CTD-2015G9.2 RP11-805I24.1 RNF126P1 RP11-863P13.5 NIFKP4RP11-344A16.2 CTD-2006K23.1 RP11-304L19.4 RP11-517C16.4 RP11-545A16.1RP11-44I10.3 MUC22 RP11-276H1.2 RP11-359E8.5 RP11-653J6.1 RP11-279O17.1EIF4BP5 LINC01616 RP11-46D6.5 RP11-626G11.1 PYCARD-AS1 RP11-388M20.2RP11-21B23.1 RP11-165M1.3 CTD-2012K14.2 RP11-578F21.3 ATP5F1P7LA16c-390E6.3 RP11-22C11.2 RP11-399O19.9 RP11-347C12.9 CTD-2576D5.4RP11-589C21.5 RP11-626G11.5 RP11-429B14.4 RP11-578F21.6 RP11-63B13.1RP11-407P15.1 RP11-82O18.2 RP11-304L19.8 CTA-30512.1 RP11-319G9.5RP11-626K17.3 RP11-16E23.3 FSCN1P1 RP11-744I24.2 RP11-553K8.5RP1-168P16.2 HERC2P11 AC002310.17 RP11-178L8.3 RP11-426L16.9 HERC2P8CTD-2033A16.1 RP11-243A14.1 RP11-79H23.3 RP11-189E14.4 RP11-357N13.3RP11-390D11.1 RP11-618N24.1 LA16c-390E6.5 RP11-489G11.3 GOLGA6L7PRP11-21L1.1 BEAN1-AS1 RP11-1C8.5 RP11-573G6.6 RP1-168P16.1 RP11-719K4.6RP11-178L8.5 LINC00165 CTD-2562G15.2 CTD-2196E14.3 RP11-480G7.3RP11-307O13.1 RP11-669C19.1 AC002551.1 RP11-506E9.3 RP11-498D10.3RP11-328J14.2 CTD-2354A18.1 DNM1P28 RP11-350O14.18 LOXL1-AS1RP11-44F14.2 RP11-691G17.1 RP11-264L1.3 RP11-303E16.6 RP11-67A1.2RP5-867C24.5 MTND5P33 GFY KYNUP1 RP11-700H6.4 AC003009.1 RP11-66H6.3RP11-177N22.3 RP11-81K2.1 RP11-1260E13.4 DKFZP434A062 AC139099.5CTD-2561B21.10 CTC-524C5.5 RP11-455O6.2 BCAR4 MTCO1P28 CTD-2033A16.3CTC-479C5.11 CTD-2318B16.2 RP11-81A22.5 RP11-462G12.1 RP11-353N14.4AC144836.1 RP11-1260E13.2 CTD-2561B21.4 MTND4P34 CTD-319515.4LA16c-380H5.2 CTB-193M12.3 RP11-676J12.8 TVP23CP2 SAMD11P1RP11-1099M24.8 RP11-95J11.1 TXNP4 LA16c-349E10.1 CTA-276F8.2RP11-334C17.5 RP11-77K12.5 RP5-1107A17.2 RP11-156P1.2 RP13-1032I1.10AJ003147.9 GLIS2-AS1 RP11-44F14.8 RP11-214O1.1 U91319.1 CTD-2545H1.1CYCSP40 CTD-2561B21.11 RP11-669E14.4 CTD-3060P21.1 RP5-1029F21.2RP11-1260E13.1 RP11-141J13.3 RP11-189E14.5 RPL23AP86 KARSP3RP11-457I16.4 CTD-2047H16.2 CTD-3088G3.6 RP11-396B14.2 RP11-388C12.1RP11-382B18.3 AC004878.8 RP11-95P2.3 RP11-189E14.3 RP5-1107A17.4RP11-1055B8.2 RP11-542C16.1 CTC-479C5.6 LA16c-306E5.3 RP11-109M19.4RP11-204E4.3 RP11-65J21.4 RP11-530N7.3 ABHD17AP5 RP11-822E23.5TMEM220-AS1 RN7SL460P CTD-2541J13.2 RN7SL471P RP11-17M24.2 RP11-973F15.2PPIAL4C RP1-56K13.2 RP11-338L22.2 RP11-78F17.1 RN7SL716P RP11-805L22.3AF186192.6 PPP4R1-AS1 RP11-269G24.3 RP11-471L13.3 RP11-321A17.4RP11-466A19.6 OOSP1P2 RP11-746B8.1 SNORA4 RP11-321A17.3 RP11-6N17.9RN7SL426P RP11-334E6.12 EEF1DP7 CTD-3010D24.3 RP11-344B2.3 RP11-53I6.2RP11-571L19.7 RP11-210K20.2 RP11-180P8.1 RP11-579O24.3 RN7SL32PRPll-434D2.11 RN7SL850P RP11-504I13.3 RN7SL42P RN7SL336P RP11-1124B17.1RN7SL744P RN7SL455P RP11-20B24.2 RP11-856M7.4 RP11-227G15.9 RN7SL784PSCML2P1 RP11-20B24.3 RP11-715F3.1 RP1-253P7.1 RP1-37N7.1 RP11-171G2.1RP11-283C24.1 RPL35AP25 RNU4ATAC ANXA8L1 RP11-6N17.1 RP11-474I11.7RN7SL488P CCDC58P1 RP11-769O8.2 SNORA77 CTD-2006O16.2 RP11-338L22.3RP4-594I10.3 RP11-110H1.8 RP11-861L17.3 RP11-605F20.1 RP11-640N20.5RP4-777O23.2 WI2-1959D15.1 RP11-145E5.5 RP11-464D20.6 RN7SL793PRN7SL326P MAPT-AS1 RN7SL732P RP11-118G23.2 CTD-2267D19.4 RP11-381P6.1RP11-498C9.17 RP11-143K11.5 RN7SL45P RP11-107K17.2 RN7SL230P AC100830.5ALOX12P1 RP11-53I6.3 RP11-661C3.2 RN7SL262P RN7SL622P AC010761.6RN7SL664P RN7SL246P FTLP12 RP11-70O5.2 RP11-31I22.2 RP11-285E9.5RP11-31I22.3 CTB-187M2.2 RP13-638C3.6 MIR133A1HG RBP3 RP11-403A21.3RP11-775G23.1 RP11-822E23.7 PGDP1 AC104984.4 RN7SL199P RP11-466A19.5RP11-16C1.1 GLUD1P7 RP11-1148O4.2 RP11-361L15.4 RN7SL656P RP11-449D8.1RP11-131K5.2 FCGR1C RP11-60A24.3 AA06 RP11-183C12.1 RP11-958F21.3RN7SL652P GLUD1P8 TUFMP1 RN7SL378P RP11-5A19.5 RP11-82O19.2 RN7SL648PRP11-883A18.3 RN7SL5P RP11-354P11.3 KYNUP2 RN7SL444P RN7SL624P RNASEH1P1CTD-2349P21.10 RP11-387H17.6 RN7SL376P EEF1E1-BLOC1S5 RP11-20B24.5RP11-737O24.2 MIR5195 RN7SL577P RP11-16C1.3 RP11-567L7.5 BAHCC1RN7SL574P RP11-118E18.2 RP5-906A24.2 FBXO36P1 RP11-354P11.2RP11-190I17.2 RP11-855A2.5 RP11-552O4.2 RP1-66C13.4 RP11-100K18.1 NPM1P2RP11-159D12.10 RP11-173M1.4 RP11-51L5.3 RP11-344E13.4 RP11-142O6.1RP11-710M11.1 RP11-180P8.3 RP11-91I8.3 RP11-822E23.2 RN7SL220PRP11-401F2.3 FAM106CP RP11-138P22.1 RP11-385D13.3 RP11-881L2.1 LINC01443RN7SL377P RP1-71H19.2 RP11-583F2.5 RP11-856M7.6 RP11-927P21.2RP11-1376P16.1 RP11-160E2.21 RP11-30L3.2 RP11-214O1.2 RP11-855A2.3RP11-1109M24.7 RP11-678G15.2 RP11-218M11.6 RP1-77H15.1 RP11-6N17.2RP11-599B13.7 ITM2BP1 RP11-744K17.8 RP11-567M16.5 CTB-171A8.1RP5-1022P6.7 SLC25A6P4 ZNF793-AS1 CTB-70G10.1 RP11-400F19.8 AC104532.3RP11-820I16.3 AC006126.3 RP11-712P20.2 RP11-116O18.1 CTC-232P5.1RP11-354P11.8 LLNLR-284B4.2 RP11-127I20.7 RP11-703I16.3 RP11-886H22.1AC002984.2 RP11-800A18.4 TCF4-AS1 RP11-807E13.2 RP11-384O8.1RP11-58G13.1 CTD-3193K9.4 RP11-128P17.2 CTB-30L5.1 AC005336.4 AC005943.2RP11-127I20.5 RP11-666A8.9 KRT18P61 RP11-15J10.9 AC005789.9 PCAT19CTD-2587H24.4 CTB-129P6.11 CTD-3064H18.2 RP11-64C12.7 CTB-31O20.6RP11-449J21.5 AC005954.3 AC005262.3 RP11-383D22.1 SDHDP1 RP11-78A19.3RP11-527L4.9 RP11-397A16.3 PHF5CP RP11-813F20.4 RP11-693L9.2CTD-2132N18.2 RP11-49K24.6 AC005786.5 HNRNPA3P16 CTB-184G21.3RP11-64C12.6 RP11-209M4.1 ZNF790-AS1 RP11-1151B14.4 CTD-2008P7.9CTC-543D15.3 CTB-129P6.4 RP5-951N9.2 RP11-567M16.1 CTB-186G2.1RP11-703I16.2 RP11-178C3.1 LINC01415 AC002398.12 RP11-411B10.3RP11-1094M14.12 RP11-1094M14.8 CTD-2231E14.5 CTC-548K16.5 RP11-1151B14.3TCF4-AS2 CTC-296K1.4 CTD-2319I12.2 AC005616.2 AC006116.15 DNAH17-AS1CTC-454I21.4 RP1-37N7.5 SMUG1P1 CTB-39G8.2 RP11-13K12.5 LOC440461RP11-126O1.4 CTC-398G3.6 RP11-815J4.5 CTC-518P12.6 CTD-3116E22.6RP11-845C23.2 RP11-13K12.1 ZNF285 CTD-2621I17.6 RP11-815J4.7 LINC00868AC007229.3 AC005779.2 AC005264.2 RP5-1052I5.2 CTC-503J8.4 STK25P1AC104532.4 CTD-2540B15.11 RP11-322E11.5 RP11-687F6.4 NDUFA3P1 RPIAP1RP11-323N12.5 CTD-3116E22.7 AC138472.6 RP11-219G17.6 RP11-1136J12.1AC138430.4 RP11-64C12.4 CTD-2008P7.10 RP11-686D22.3 RP11-95O2.1RP11-973H7.4 RP11-807E13.3 RP11-358B23.1 CTB-55O6.4 AC010525.5RP11-1030E3.1 ERVK-28 CTD-2013N17.4 RP11-108P20.3 CTD-2105E13.6RP11-95O2.5 RP11-147L13.7 AC024592.9 CTD-2189E23.1 AC010761.14RP11-64C12.3 RP4-604K5.3 HMGB2P1 AC061992.2 RP11-686D22.8 RP11-358B23.5RP11-559N14.6 RP11-677O4.4 RP11-2N1.2 RP11-154H12.3 SLC25A36P1CTB-55O6.10 CTD-2659N19.2 RP11-49K24.5 CTB-191K22.5 CTB-133G6.2RP5-1023B21.1 RP11-120K24.3 ZSCAN5D CCDC177 CTD-2525I3.2 CTD-2620I22.3CTB-189B5.3 CTD-252513.3 CTC-244M17.1 AC067969.2 CTD-3032J10.2 BNIP3P40TOP1P1 SLC6A14 CTB-60B18.12 VN1R84P CTD-3193O13.11 AC003002.4Metazoa_SRP AC010524.4 AC004076.9 RP11-556I13.2 AC002985.3 FKBP4P6CTB-60B18.18 CTD-2623H2.7 CTD-3222D19.11 BNIP3P25 LRRC2-AS1 L34079.2CTD-2568A17.8 CTC-360J11.4 FENDRR TRMT112P6 CTD-2626G11.2 AC011551.3AC011530.4 BNIP3P27 BNIP3P38 ABC7-42418200C9.1 AC018755.18 CTD-2545M3.8RP11-32B5.8 AC004076.7 AC005523.3 AC003956.1 RP11-514A9.1 VN1R80PCTD-2207O23.10 CTB-52I2.3 RP1-122P22.4 RP11-739B23.1 CTB-33G10.11CTD-3187F8.7 CTB-60B18.10 LETM1P2 FAM231B CTD-2553L13.4 RP11-588H23.5CTC-444N24.9 CTD-2105E13.14 CTD-2561J22.1 CTB-61M7.2 CTD-2396E7.7CTD-3030D20.1 AC104534.2 ADGRE4P CTC-450M9.1 VN1R90P CITF22-62D4.1SIGLEC22P CTB-167G5.6 PNMA6B CTD-3099C6.7 CTD-3233P19.8 CSAG3RP11-886P16.6 AC005387.3 CT45A1 ERVV-2 AC005253.4 SPANXN2 RP11-439A17.5RP1-172N19.1 KRT18P40 MTRNR2L12 CTC-513N18.6 CTC-360G5.6 CTD-2528A14.5RP11-256I23.2 CTD-3222D19.10 AC010646.3 CTD-2525I3.5 TRABD2B BRI3BPP1RP3-431P23.5 CTC-218B8.3 AC005387.2 ZNF350-AS1 CTB-83J4.2 CTD-2105E13.15CTD-2527I21.7 AC010522.1 CTD-2278110.6 CTC-453G23.4 CTC-312O10.2CTD-2616J11.11 LINC01224 BNIP3P8 CTD-3032J10.3 Z69720.2 CTB-174O21.2DMRTC1 CYP4F23P CLIC4P2 CTD-2192J16.21 CTD-3222D19.5 TDGF1P7 CTB-167G5.3RP11-542M13.2 CTD-2521M24.11 AC005614.5 CTB-60E11.9 CTB-180A7.3GLTSCR1-AS1 SCGB2B3P RP11-11A5.1 CTD-2537I9.16 CTD-2587H19.3 AC004754.3RP11-463C8.7 RP11-266J6.2 RP11-477H21.2 RP5-1139B12.2 RP4-740C4.5RP11-178L8.9 RP6-99M1.3 RP11-442H21.2 RP6-91H8.3 RP5-1139B12.3RP11-394O4.5 RP11-214K3.20 RP11-2B6.3 RP11-248J23.6 RP11-324I22.3RP11-148O21.6 SPACA6P-AS RP11-498E2.9 RP3-426I6.5 RP3-430N8.10RP11-130L8.2 RP11-282O18.7 RP3-430N8.11 AF003625.3 RP11-272L13.3RP3-449M8.9 RP11-218C14.8 RP11-93H12.4 CTD-2132N18.4 RP11-380L11.4RP11-685G9.4 RP11-416A14.1 RP11-214K3.22 WI2-80269A6.1 MIR222HGRP11-750H9.7 RP11-351121.11 KB-1958F4.1 AP000473.8 RP11-214K3.18 RNU11RP11-245P10.6 RP11-326C3.14 RP5-1139B12.4 VTRNA2-1 RP11-118F19.1RP11-214K3.23 TERC RP11-568J23.6 LA16C-380H5.3 RP11-494H4.3RP1-170O19.24 RP11-803D5.4 RP11-89C3.2 AC015849.2 RP11-779O18.4CTC-471J1.10 RP11-420B22.2 RP11-17P16.2 RP13-122B23.9 RP11-731D1.4RP11-453E17.4 RP11-566F5.1 STX8P1 RP11-461L13.4 GS1-165B14.2 B0RCS7-ASMTRP11-697E2.10 BNIP3P9 UNGP3 RP11-547M24.1 RP11-470B22.1 CTC-412M14.5RP11-44D5.1 RP11-351O1.4 RP11-1348G14.6 OR7E108P RP11-511111.2RP11-972P1.8 RP11-411B10.8 IGHV3-29 RP11-230C9.3 MKI67P1 YTHDF2P1RP11-24C14.1 RP11-145P16.3 RP11-311H10.7 RP11-15E18.5 RP11-225N10.3RP11-362B23.1 RP11-713H12.2 RP1-134O19.3 LOC401913 RP11-373D23.2 TSIXHNRNPA1P67 CTB-17911.3 CTC-512J12.7 RP11-349G13.3 RP11-381K20.4RP11-568J23.7 RP11-568G11.5 RP11-231P20.5 RP4-802A10.1 IGKV2OR2-1 DEARRP11-138E2.1 CTD-2324A24.2 AD001527.7 PDHA1P1 RP13-685P2.7 RP11-501C14.9PDLIM1P1 RP11-632K20.8 DPRXP6 RP11-416H1.1 RP11-574K11.27 CHCHD2P11RP11-730B22.1 RP3-466P17.2 RP1-168P16.3 CTC-571O20.1 RP11-674I16.1VDAC1P5 RP11-420K10.1 RP11-609L3.1 RP11-311B14.1 GPR75-ASB3RP11-272L13.4 RP11-27M5.1 SRD5A3P1 XXbac- RP5-879K22.1 RP5-966M1.5HSPE1P7 BPGBPG24O18.1 RP11-62H7.3 RP11-54C4.2 RP11-137J7.3 RP11-123C21.2RP11-439C15.5 RP11-844P9.4 CTHRC1P1 CTC-539A10.7 RP11-60E8.2RP11-963H1.1 RP5-933K21.3 RP11-1113N2.4 CTD-2342N23.2 CTD-2553L13.7RP11-479I16.2 RP11-457M11.6 PHBP20 NAMA SUMO2P14 RP11-223J6.1RP11-123C5.5 RP11-33A14.3 RP5-966M1.4 YWHAQP7 RP11-479F13.1 RP11-642C5.1RP11-409O11.3 RP11-629P16.1 RP5-855F16.1 RP4-555D20.3 RP13-216E22.5RP3-523E19.2 RP11-369K17.2 KRT18P9 RP5-894D12.4 SUMO2P15 RP11-424I3.1CTD-2117L12.3 RP11-1109F11.5 TCEB1P33 CTC-412M14.6 DPRXP2 RP11-1152H14.1RP11-1109F11.3 RP5-891H21.5 RP11-797J4.1 RP11-701H24.7 RP11-843B15.3RP11-81A1.8 RP3-483K16.4 RP11-253I19.4 RP11-33I11.3 C8orf59P2RP11-382D12.2 RP1-161P9.5 IGKV2OR2-2 MZT1P2 PRR13P3 RP11-751K21.1RPL23AP90 RP11-295B17.6 MMP28 CT45A2 CICP24 RP4-799G3.1 CTC-559E9.9RP11-603B24.6 RP11-36B6.1 ARF4P1 RP11-692M12.5 RP11-579D7.8 RP4-665N4.8RP11-52M17.1 RP3-418A9.3 HSPE1P14 ACTG1P22 RP11-435I10.5 RP11-289A15.1MARK3P1 RP11-270B14.1 RP11-95I16.4 RP11-1E1.2 RP11-564A8.8RP11-1259L22.2 RP11-393B14.2 BNIP3P20 RP11-312P12.3 CTD-2256P15.5RP11-169K17.4 CTD-3020H12.4 RP11-787I22.3 RP5-1182A14.5 CTB-113I20.2RP4-680D5.9 XXbac- RP11-87N3.6 BPGBPG55C20.3 RP11-254F7.3 SNORA51RP11-426L16.10 RN7SKP4 RP5-894D12.5 RP11-337N6.2 RP11-1C8.7RP11-436D23.1 CTD-2228A4.1 RP4-789D17.5 RP11-44N12.5 RP11-63L7.5RP11-222K16.1 CTD-3064M3.7 CTD-2140B24.6 RP11-134K13.4 U47924.29AC226119.4 RP11-28H5.2 RP11-345P4.10 CTC-350I8.1 CTB-40H15.4 FAM231DRP11-332J15.4 CTD-2376I4.2 RP11-542A14.2 CTD-2653M23.3 XXcos-LUCA11.5AC005754.8 CTD-2366F13.2 KB-1836B5.4 RP11-360I2.1 RP11-107C16.2LINC01607 RP11-465B22.8 RP11-350N15.6 RNU4-5P PROX1-AS1 CASC15RP11-387M24.5 RP4-657D16.6 RN7SL803P AC004775.5 RP3-500L14.2 RP11-11N5.3RP5-855D21.1 KB-1958F4.2 RP11-346C20.4 RP11-489E7.4 RP11-305P22.9TPTE2P2 RP11-394A14.4 RP11-506K6.4 KB-1517D11.4 RP1-151F17.2RP11-307L14.2 RNU4-89P RP11-359I18.5 RP11-446N19.1 RP11-25O10.2RP11-441F2.5 RP11-556O9.4 RP11-284F21.10 RP11-185E12.2 RP3-511B24.5RN7SL778P RP11-54O7.16 RP1-225E12.3 RP1-136B1.1 RP11-95G17.2RP11-158G18.1 RP1-317E23.7 RP11-474O21.5 RP11-169K17.3 RP11-284J1.1RP5-1024N4.4 RP4-535B20.4 RP11-96C23.14 RP11-255P5.2 RP11-351J23.2RP11-324L17.1 RP11-480C16.1 RP11-462G22.2 OR10AH1P RP11-737O24.5GS1-259H13.13 AP000320.7 RP11-190A12.8 PCDHB16 RP11-797D24.4RP11-216L13.18 AC004471.10 RP11-290M5.4 RP1-63G5.8 RP11-78A19.4RP11-534C12.1 CTB-161C1.1 OR7E47P KB-208E9.1 RP11-222G7.2 RP11-155D18.12RP11-74E22.5 RP11-433A10.3 RP1-170O19.23 U91328.22 RP11-15I20.1RP6-74O6.6 RP11-91K8.5 OR10AE3P RP1-137D17.2 RP11-332H14.1 RP5-1103G7.10RP11-98C1.2 RP1-309K20.6 RP11-299H21.1 RP11-121A8.1 RP11-724N1.1RP11-330O11.3 RP11-500M8.7 RP11-307C18.1 OR7A19P RP11-190C22.9RP11-329B9.4 RP11-284F21.11 RP5-1180E21.4 RP11-85E16.1 RP11-150D20.5ARL2-SNX15 CTD-2303H24.2 RP11-508N22.13 RP11-285F16.1 FAM95C ATF4P2RP4-569D19.8 RP11-834C11.14 RP11-834C11.12 CTA-714B7.7 GRIN2BRP11-1275H24.3 RP11-201K10.3 RP11-532L16.3 RP3-508I15.20 RP11-350G8.9RP11-350J20.12 RP11-290D2.6 RP11-406H21.2 RP11-104L21.3 RP11-307N16.6CTB-96E2.2 RP3-510H16.3 RP11-20I20.4 CTD-3148I10.15 AP000692.10RP4-549L20.3 RP11-107N15.1 CTC-432M15.3 RP11-644N4.1 RP5-1180E21.5KB-7G2.8 SERPINA3 ZBTB8B RP6-109B7.5 RP11-445N20.3 CTB-13L3.1 RBAKDNRP11-141M3.6 RP5-899E9.1 RP11-466F5.10 RP11-96C23.15 RP4-597N16.4RP1-170O19.22 AC006946.17 RP11-54O7.18 RP5-1147A1.2 RP11-305O4.3RP11-102N12.3 RP11-108L7.14 RP4-671G15.2 RP4-621B10.8 RP11-80H18.4RP11-50D16.4 HIST1H4K OR4F16 CTD-2049O4.2 CTD-2024I7.18 RP11-426C22.7RP11-861L17.4 RP11-433A19.2 ST7-OT4_1 RP11-392A14.9 CTD-2564P9.3RP11-66N24.7 uc_338 MIR142 RP11-15E1.4 RP11-406H23.5 RP11-566K19.8RP5-837J1.6 CT45A7 LHX1 RP5-1021I20.8 U1 LLfos-48D6.2 RP11-420C9.1RP11-370I10.11 CEACAM20 RP11-620J15.4 RP11-81H14.1 RP11-394O2.3AL078471.5 RP11-133K1.12 RP11-174N3.4 RP11-603J24.21 RP11-227D13.5RN7SL733P RP11-346J10.3 CTD-2306A12.1 Metazoa_SRP RP11-332H18.7RP11-585P4.6 Metazoa_SRP RP11-732M18.4 RP11-340F14.6 RP11-570L14.1ABC12-47964100C23.1 RN7SL539P RP11-140H17.2 FAM27AP1 RP11-474C8.8Metazoa_SRP AC018737.1 RP11-407N8.6 AL133243.3 RP4-568C11.4LLNLR-284B4.1 KB-68A7.1 RP11-357P18.2 RP4-545L17.12 ADRA2B RP11-20G13.5SNORA71E PCA3_1 RP11-239C9.1 RP11-717F1.2 RP11-227G15.10 TTC28-AS1_3RP11-40B20.1 RP11-203I16.7 RP11-216L13.21 LL22NC03-84E4.13 RP5-994D16.11RP11-154H23.5 CTD-2540L5.9 RN7SL196P RP11-972P1.10 C8orf89 RP11-323P17.2RP11-58A18.2 RP4-583P15.16 Metazoa_SRP RP5-965G21.5 CTC-338M12.13RP11-146B14.1 SEBOX RP1-62D2.4 RP11-434C1.6 CTD-3035K23.7 RP11-819M15.2RP11-474P2.5 ST7-OT4_4 CTC-260E6.12 RP11-49G2.3 TBC1D3J RP11-986G18.2Metazoa_SRP RP11-2C24.7 Metazoa_SRP RP1-47A17.1 RP11-618L22.1 CCL23TCEB3CL2 RP1-59D14.10 AC131056.3 RP11-407N8.5 Metazoa_SRP Metazoa_SRPRP11-49I11.4 RP11-136L23.2 RP11-214K3.25 RP11-65I12.1 CTB-167G5.7CTD-2311M21.4 RP5-1009E24.9 SPDYE13P RP3-492J12.2 RN7SL600P CTB-58E17.2MIR6753 AC233755.1 CH17-262O2.1 GNAS-AS1_5 SNORD91B RP11-442O1.3RP11-711K1.8 RP11-182J1.17 CH17-219N22.1 RP11-324D17.3 CCL16RP11-385J1.3 RP11-4B16.3 AC008984.2 RN7SL544P FTX_3 RP11-428O18.6Metazoa_SRP RP11-234G16.4 SPDYE19P RP11-83N9.6 CTD-2017F17.1RP3-425C14.6 RP11-329N22.2 ZEB2_AS1_1 RP11-346J10.2 RP11-125A15.3 HNF1BRP11-844G16.3 RP11-126O1.6 LA16c-360A4.1 RP11-569G13.3 RP11-793H13.12RP11-322E11.2 RNVU1-19 TCEB3CL RP11-3K24.3 Metazoa_SRP XKR5RP11-802O23.4 RP11-35J10.6 RP11-12A20.12 RP11-209D20.2 KCNQ1OT1_1RP11-876N24.7 RP11-1021O19.2 CCL15-CCL14 U47924.32 RP4-777L9.3RP11-100G15.12 HNRNPCL2 RN7SL736P HTR1DP1 RP4-697K14.15 RP11-479O9.3CTC-421K24.1 LINC00162 IKBKGP1 RP11-497G19.7 Metazoa_SRP RP1-278C19.8uc_338 EIF3FP1 AC108479.3 RP11-180M15.6 CTD-2240J17.4 REXO1L12PKCNQ1OT1_5 CTD-2027I19.3 RN7SL197P CH507-152C13.3 RP11-507M3.1RP11-734B5.2 RP11-455O6.8 RP4-790G17.7 CTD-2008A1.3 RP11-154D6.2 SNORA43TP73-AS1 LINC00226 RP4-781B1.5 PIK3R6 SCARNA10 OR4E1 CTB-91J4.1CTB-32O4.3 AC011043.1 RBBP4P3 GTF2IP8 UPF3BP1 RP11-241M13.2 RP5-928E24.4RP11-106D4.3 Metazoa_SRP FLJ36000 VN1R9P RP11-490B18.5 CCL14 HIST1H2BBRP11-157L3.9 RP11-266K4.13 NPPA-AS1_1 RP11-210K20.6 RP11-400G3.5Metazoa_SRP BMS1P14 CMB9-94B1.2 RP11-295H24.5 RAB7B RP11-300D11.3 DACH1Metazoa_SRP RP11-35J10.7 IGKV1OR1-1 RP5-1057I20.5 RP13-977J11.9RP11-3D4.4 Metazoa_SRP YWHAEP7 Metazoa_SRP RP11-381O6.1 RP11-500G22.4RP11-461A8.5 CH17-125A10.1 RP5-1116H23.5 CTD-2515H24.2 RP11-290H9.5RP11-374M1.10 RP11-19G24.2 Metazoa_SRP CH17-360D5.2 RP5-875H18.9AL662801.1 RP4-608O15.3 GSTTP1 RP11-318K12.1 HYDIN2 CTD-3128G10.7LA16c-359F1.1 MIAT_exon5_3 RP11-476H16.1 RP3-453C12.15 SNORA71RP11-101P17.15 RP5-1116H23.6 RP11-520B13.8 RP11-113A11.3 CTD-2024F21.1SNORA9 RP13-554M15.8 RP11-89G4.1 AC007325.2 CH17-125A10.2 RP11-74E22.8SDR42E1P2 RP4-550H1.7 RP11-153I24.4 Metazoa_SRP RP13-580B18.2 RN7SL556PATP5A1P10 AP003041.1 RP11-699C17.1 RP11-157L3.3 RP11-462D18.4RP11-141M1.4 Metazoa_SRP CH17-385C13.2 REXO1L6P RP5-1116H23.3 XXbac-BPG154L12.5 RP11-256K9.1 RP11-538C21.2 CTB-96E2.10 RN7SL473P RN7SL286PAC213203.1 AL022345.10 PKD1L3 Metazoa_SRP RP13-347D8.7 RP11-298C2.1RP11-746P2.6 RP11-73M11.3 RP5-1057B20.3 UPF3BP4 RP3-468O1.6 CTD-2525I3.8CTC-268N12.3 CTD-3116E22.8 RP11-12A20.8 RP11-295M3.4 RP11-255M2.3AC009133.22 Metazoa_SRP XXbac- RP11-459O16.9 Metazoa_SRP ZFAT-AS1_2FP325317.1 RP11-693J15.6 B33L19.15 Metazoa_SRP GOLGA6L17P RP11-757O6.7H2AFB3 ABC7-42404400C24.1 CTD-2588E21.1 RN7SL763P Metazoa_SRPAC005752.10 SMAD5-AS1_1 GOLGA6L22 FAM230A RP11-33N14.3 RP11-467P22.5RP11-122G18.9 SNORA76C RP5-851M4.1 RP11-333J10.2 RN7SL478P uc_338Metazoa_SRP RP11-90D4.4 HOXA11-AS1_4 XXbac- B562F10.12 RP11-428P16.3RP11-735A19.3 SNORA67 RP11-356M6.1 RP11-426C22.8 RP11-157L3.11RP11-35O15.2 SOX2OT_exon4 CTD-2240J17.2 NEAT1_2 TEX28 RP11-466M21.1RP11-15E1.6 RP11-525G12.1 U1 RP11-972P1.11 AC116050.1 NEAT1_1CTD-3028N15.3 RP11-476I15.5 CH17-262O2.2 SSTR3 RP13-766D20.4 CNTNAP3P5RP5-906C1.1 uc_338 AC020956.3 UPF3BP3 Metazoa_SRP SNORA61 RP11-55J15.2RP3-324O17.8 CT45A6 GRAMD4P3 RP11-1006G14.5 XXbac- BPGBPG34I8.2CTD-2267D19.7 OR7E104P MIAT_exon1 RP11-255P5.3 CTD-2240J17.3RP11-261C10.8 RP11-66B24.9 RP11-165D6.1 RP11-19E18.2 RP11-144H23.2UPF3BP2 RP11-123C21.3 RP11-108K14.12 RP11-432I13.6 IGKV2OR2-8 OR4F29CTA-313A17.5 RN7SL113P TBC1D3E RP11-405M12.3 RP11-506H21.5 CTD-2318O12.1CTC-268N12.2 CDK2AP2P1 RP11-434C1.4 RP11-49K24.9 IQCA1L LA16c-352F7.1AC000403.4 Metazoa_SRP Metazoa_SRP RP5-1116H23.4 AC007325.4 Metazoa_SRPNPPA-AS1_2 RP11-567L7.3 PRO1804 RP11-108A14.1 RP11-183A22.3 CTC-448F2.7CTD-2342N23.1 RP11-65F13.3 RP11-523J2.1 RP11-401P9.7 CTD-2299N12.1RP11-137O10.1 RP11-139H14.5 AC104981.1 SMG6-IT1 RP11-67H24.3 RP11-39H3.2RP5-849H19.3 RP11-662I13.3 CTD-3022L24.1 RP11-426J5.3 RP11-762L8.6RP11-1430O6.1 RP11-360A10.1 RP11-697K23.3 RP11-391L3.4 RP11-131P10.2RP11-81K2.2 AC007787.3 CTC-270D5.1 CTGLF11P CH507-216K13.1 CTD-253719.15CH17-140K24.5 RP11-83B20.3 RP11-322E11.3 RP1-167O22.1 RP11-461F11.2AL356289.1 RP11-823P9.4 CTA-243E7.1 RP11-83B20.5 RP11-394B2.3RP11-76C10.4 RP11-264L1.2 LINC01451 AC139099.7 RP1-163M9.7 RP11-43D4.3RP11-287D1.5 CTA-113A6.1 RP11-632P5.1 RP5-991G20.6 CTA-212A2.3RP11-263G22.1 GPR1-AS RP11-543H23.1 CH507-152C13.5 AC019206.1RP11-195O1.5 CMB9-22P13.2 RP11-536C12.1 LA16c-380A1.2 CTD-3137H5.5RP11-573M3.5 CTA-345G4.1 RP11-64C12.5 CTD-3149D2.2 CH507-145C22.4RP11-75I2.3 RP11-83B20.6 RP11-864N7.4 RP11-776B3.1 AGPAT4-IT1RP11-475D10.4 RP11-360N9.3 RP1-247F3.1 RP11-1182P23.5 RP11-650L12.4CH17-140K24.6 AC003973.3 AC069063.2 AF127577.13 RP11-81A1.4RP11-369J21.12 CTD-2353F22.2 RP11-849I19.2 RP11-382B18.1 LINC00244RP11-641J8.1 RP11-258F1.2 RP11-190A12.9 RP11-218M11.7 CTD-2576N18.1LA16c-313D11.13 AC005915.1 AC006026.2 AC005480.1 RP11-44D5.2RP11-386I8.5 AC009065.4 CTD-2286N8.1 RP11-391L3.3 RP11-91I8.2RP13-977J11.3 RP11-391A7.1 RP11-392A14.8 CTD-2576D5.1 RP11-72I2.2RP11-354E23.4 AC243945.1 RP11-676B18.1 RP11-575M22.1 GS1-306C12.1RP11-83B20.2 CTB-96E2.6 AC009022.1 RP11-133K1.8 OR4X2 AC087762.1AC005786.6 AC002044.1 RP4-566L20.1 RP11-637C24.5 RP11-502F1.1RP11-348J12.5 RP11-235C23.6 AC005796.2 RP11-399C16.3 RP11-573G6.4RP11-989F5.4 RP11-521H3.3 RP11-507J18.5 RP11-1086I4.2 RP11-278J6.5RP11-274A11.5 RP11-755E23.2 MAPT-IT1 ECSCR CH507-9B2.8 RP11-485M7.2RP11-71L14.3 CTD-2028E8.2 CTD-2335A18.2 CTD-3035K23.3 CTA-212A2.2LLNLF-158E9.1 RP11-81A1.7 RP11-416H1.2 AC124312.1 RP11-79C6.2RP11-44F14.9 CH507-42P11.3 CTD-2169H9.1 RP11-278H7.5 AC004813.1RP11-586K12.2 RP11-499E14.1 RP11-665E10.2 RP11-586K12.1 RP11-317F20.3CTC-510F12.3 AC005538.3 RP3-495K2.4 CR392000.1 RP11-394B2.7 AC010287.1RP11-142L16.2 RP11-775C24.4 RP11-648O15.2 RP11-504G3.2 RP1-228P16.9RP11-20F18.1 CH507-216K13.2 AC005618.9 RP11-539L10.4 RP11-570J4.1RP11-420N3.3 CTB-151G24.2 CTD-2315M5.2 RP11-483E17.1 RP11-264L1.1FLJ42393 GHc-857G6.7 BIRC6-AS2 RP11-360N9.2 RP11-481J8.3 FO538757.3RP11-145E17.3 LA16c-312E8.4 RP11-243M5.5 CH17-76K2.6 RP11-483I24.1WI2-85898F10.2 RP11-141B14.2 RP5-1181K21.4 RP11-472K17.3 CTD-2553L13.5RP11-243M5.4 GABARAPL3 CH17-140K24.8 CTC-436P18.4 RP11-76C10.3CTB-139P11.2 AL353997.3 AC005086.2 CTD-2123J17.2 RP4-671O14.7RP11-118E18.1 CH17-140K24.2 RP11-10J21.2 RP11-540O11.8 DNM1P41AL133335.1 CTC-463A16.1 RP11-61K12.2 RP11-5G9.6 LA16c-380F5.1RP11-907D1.3 RP11-361H10.5 CTC-312O10.3 AC002044.3 OR1B1 CH507-42P11.7RP11-334E15.1 RP11-423G4.8 RP11-133M8.3 RP11-158L12.6 AC093642.1CTD-3137H5.4 AC073333.1 AC016142.1 RP11-331F4.5 RP11-314N13.9RP11-354E23.3 CH507-210P18.3 RP5-906A24.1 CH507-42P11.6 RP11-319G9.1CH507-42P11.5 RP11-243M5.2 RP11-504I13.2 RP11-174G17.3 RP11-454F8.3RP11-67L14.1 AL590235.1 RP11-321N4.4 RP11-159D12.3 RP11-145P16.2RP11-574K11.26 AL049794.1 RP5-1037N22.2 MTCO1P1 RP11-44N21.3RP11-466A19.4 RP11-6L6.6 RP5-1007F24.1 RP11-340F16.2 RP11-560F18.1RP11-556H2.1 RP11-314C9.1 RP11-340L3.1 FRG1KP RP11-177H2.1 RP11-78J21.6RP11-583F2.7 RP11-64C12.1 CTD-3076M17.1 RP11-665E10.4 RP1-111J24.1RP11-1110F20.1 RP11-545D22.1 RP11-667K14.14 RP11-15F12.6 RP11-438L7.1CH507-152C13.4 RP5-1065O2.4 RP11-83B20.4 AC092159.1 RP11-9H20.2RP13-204A15.5 RP11-93O14.3 CTC-503J8.8 RP5-898I4.1 RP11-42F12.1RP11-818O24.2 AC007326.10 CITF22-92A6.2 RP11-446E24.3 AC104057.1Metazoa_SRP SNORA16A AC092636.2 RP11-35J1.2 AL031777.1 Metazoa_SRPLINC01348 SCAANT1 RP11-96C21.2 Metazoa_SRP AP002518.1 SH3PXD2A-AS1RP11-275E15.3 PCAT5 AC133644.2 AC137695.1 AC090181.1 RP13-465B17.5Metazoa_SRP AL049822.1 AC239868.2 RP11-68E19.2 AC009133.23 LINC00628Metazoa_SRP Metazoa_SRP RP1-12G14.9 RP4-777O23.3 U91328.1 AC239868.3LINC01127 LINC01097 AL009179.1 LINC00997 Metazoa_SRP Metazoa_SRPLINC00506 Metazoa_SRP BLACAT1 TGFB2-OT1 AC010168.1 RP11-223J6.2DNAJB5-AS1 LINC00538 Metazoa_SRP ERC2-IT1 AC093373.1 C2-AS1RP11-567F11.2 AL031777.2 Metazoa_SRP Metazoa_SRP RP11-439M15.1Metazoa_SRP RP3-510D11.4 CTB-127M13.1 RP11-126O22.10 RP11-126O22.9CTD-2336O2.3 TMBIM4 RP11-506F3.1 CTA-286B10.8 RP4-621F18.2 CICP19HSP90AB4P OR4G3P RP11-27G14.4 RP11-126O22.8 CYP3A7-CYP3A51PRP11-126O22.2 RP11-126O22.4 RP11-496N12.9 RP5-1052M9.5 FAM138FCTA-286B10.7 C11orf71 CH17-31A6.1 AC008993.3 FRG1DP AKR1C3RP11-307E17.11 RP11-731J8.3 LA16c-407A10.3 BLOC1S5 CTD-2195M15.4RHOXF1P3 TRBV7-2 RP11-683L23.7 RP11-807C20.2 KB-1396H2.2 CDC27P3RP1-273N12.4 RP11-176H8.3 DUX4L37 RN7SL1 RP11-557N21.1 FRG1FPRP11-210L7.3 RP11-417N10.5 RP11-834C11.15 CTD-2331H12.8ABC11-4932300O16.1 RP11-964E11.3 CTC-325H20.8 RP11-107E5.4 HYMAI WASIR1IL3RA CRLF2 RP13-297E16.4 RPL14P5 LINC00685 DDX11L16 LINC00102RP13-465B17.5 CLSTN3 EIF3H EDF1 JMJD8 ASPM E2F4 USP33 FBXO9RP11-143J12.3 AFF3 CCBE1 AC000120.7 KPNA6 GPR183 CTD-2616J11.9 SMAD2CDKN2B-AS_3 PVT1_1 COPS2 LOXL3 OFD1 SCARNA8 Y_RNA SNORA1 CSPG4P5 BRS3KLF14 NOTO PLEKHS1 PLA2G4E-AS1 CTD-2525P14.5 RP11-252I13.1 IHH NECAB1CTD-2647E9.1 RP1-80N2.4 RP1-257C22.2 ARIH2P1 EEF1A1P22 ZNF415 RPL4P3MYO5BP1 ABCC5 SRPK2P GLYAT SDC2 HNRNPA1P37 SEPT14P2 OR52B3P HMGN2P6OR7E37P VN2R10P PRPF38AP2 TSPAN15 DBF4P1 IL1RAP HIGD1AP14 HBE1AC006116.27 RP11-734K2.3 YWHAZP6 CACNA1C-AS4 RP11-433P17.1 AC010987.6CDC27P1 RP11-390P2.4 RP13-580B18.4 RP11-756J15.2 RN7SL466P RP11-309L24.4PSMA2P3 RP11-112J3.16 HERC2 IGHEP1 RP11-434D2.9 RP1-50O24.6 ZNF354CRPL15P2 ERHP1 RP11-92C4.4 AC012363.4 HMGB3P10 RP11-286H14.4 AC002064.7RPL34P34 RP11-686G8.5 CTD-3131K8.3 RP11-322E11.6 BCAS3 TRAV14DV4 TBX21AF196972.4 MUC1 CTD-2284J15.1 RP11-276E17.2 RP11-323F24.4 PGAM1P10 SEZ6GPR151 RP11-542F9.1 KCTD16 ZNF330 RP11-732A19.2 RP11-523O18.1RP11-452L6.5 CTC-251I16.1 MAGT1 NF1 SERPING1 U3 RP11-475E11.9 PRR4CTAGE15 PP14571 RADIL PCDHGB2 WASH6P WASH6P RP11-329N22.1 ME2 BHLHE41WBP1 CFHR3 RP4-694B14.8 GPATCH1 RP11-427L15.2 MARCH7 DUTP2 GLO1 SLC8A1RP11-466F5.3 PRKAG1 C1orf216 RP5-1009N12.1 ACAA1 HNRNPA1P5 CEP85LAC003005.2 RNU2-2P TMPRSS6 TMX2P1 RP4-706A16.3 RP11-76H14.2 PRPSAP2RP11-164P12.5 RP11-535A19.1 NKPD1 CLUL1 SLC16A2 RP11-667K14.8 YWHAZPAX8-AS1 G3BP1 RP11-524F11.2 RP11-247A12.7 TMEM25 RP3-380B8.4RP11-160A9.3 RN7SKP160 NTNG1 RP11-133K1.9 CTC-534A2.2 GNB1L S100A16CTC-246B18.10 COX5BP6 AATF RN7SL77P RP11-265B8.5 S100Z LDHAP2 ACTR3RBBP7 RP11-347P5.1 C19orf84 PRRT2 TCF25 RPS2P7 NFATC1 AC009005.2 MORC3CKM HIC2 RP11-468O2.1 SNORD22 RP3-405J10.5 CEP57L1P1 PAK2 RP11-12A20.6RP11-53OC5.1 AF196972.9 EIF1AX-AS1 CFL2 CALB1 RP11-876N24.4 NDUFB6SDHDP2 C6orf163 WNT2 RP11-98D18.16 LDHAL6A DDX50P2 IFITM3 MAP2K5 BAG2LAMC2 RP4-593C16.4 RP11-848P1.5 CTD-3035D6.1 LCMT2 CYP3A4 NT5DC4 H2AFZP6ZDHHC20P4 FOXD3 DNAJA1P3 RPL21P119 HNRNPA3P1 HLA-DQB1 RPSAP76 GPR45LAMB3 RP11-756A22.7 CCDC181 RNF5 RP11-316M21.6 RALB RP11-15B17.2 P3H3RP11-429B14.1 HOXC10 SAMM50P1 PPP1CB RP11-323I15.2 RP11-428C19.5 SS18L2EXOSC4 RP11-2K6.1 GYS2 VDAC2P3 TENM1 UBXN4 TBC1D7 RP11-507E23.1 ANKRD49SMIM12 RP11-71L14.4 GLTP RP5-1092A3.5 RP11-317N8.4 XXbac- B444P24.14AP003068.18 RP3-414A15.2 LDHBP2 RP5-1050D4.3 CCDC183 USP5 AC007249.3ABCF3 RP11-671J11.4 HNRNPKP2 RP11-80I15.1 ZCCHC11 RPS21P1 CYS1 RGPD4RP11-284F21.9 RP11-571M6.15 LRRC69 F5 AF131215.1 RAD18 RP11-872D17.8GRPR ST3GAL2 RBBP8P1 TACSTD2 RP11-316O14.1 RP11-638I2.10TBC1D3P1-DHX40P1 RP11-326A19.3 RP11-1070N10.5 RUNX2 SULT2A1 PDE8B ITIH4TG MORF4L2-AS1 GAS1 STC2 RN7SKP269 RP11-440I14.2 HSPD1P5 RP11-503I22.2RP11-757G1.6 RP3-467L1.4 SEPHS1P4 RPL18 NOTUM WWP1P1 RP3-391O22.3CTD-2587H24.1 CTA-384D8.36 ASAP1-IT2 NOXO1 AL603831.1 RP11-84C10.1THCAT158 HARS RP11-158M2.2 RN7SKP150 SYT5 S100A11P2 TERF1P4XXcos-LUCA16.1 ANGPTL3 GTF2IP5 SHH AC004057.1 NEPNP GDF7 RPL21P75RP11-438L7.3 RP11-329N15.3 CEBPZ CTA-150C2.20 KCNC4-AS1 AC079354.5 SDC1RP11-250B2.3 EIF5A2 RP11-259O2.3 PSMD5 ATAD2 RP11-17E4.1 MARCH8RP11-405L18.4 RP11-242D8.3 RP11-723D22.3 MAGEA6 LINC00242 CTC-499B15.7SCDP1 RP11-1072C15.6 VPS13A PSME4 RP11-1090M7.3 KB-1460A1.1 SERPIND1CENPUP2 PHGR1 LLNLF-173C4.2 HMGN2P3 FOXD1-AS1 CLCP2 AC007163.3 KRIT1NPTN-IT1 TGOLN2 RP4-811H24.9 RP11-582E3.4 RP11-80H5.7 MTCO1P31CTD-2073O6.1 VASN PTTG4P RP11-498C9.16 VWA5B2 RP11-572N21.1 HSFY3PFBXO40 RP11-96C23.13 RP11-111J6.2 DYNLL1 MTRF1 ZNF488 SDC4 AK3P5RP11-82O19.1 ZNF962P SPARC RP11-820K3.3 IL7 RPL29P23 RP11-13J8.1LINC00462 RP11-541P9.3 RP11-66B24.2 AC004951.5 SNRNP40 OAS1 AC159540.14RP11-770J1.7 CASS4 RP11-544O24.2 CPNE7 KNOP1 RP13-638C3.5 STX2 PHKG2RP11-709D24.8 RBM41 AC007743.1 FCN1 HSPE1P4 RP11-576I22.2 CBX5P1RP11-303E16.5 EGF HECW2 RP11-693J15.3 RP11-323J4.1 GTF2IP23 RP11-379B8.1RP1-93H18.1 ECM2 RP11-1094M14.7 SLC5A3 RP11-426C22.1 NAT8L RP11-596D21.1CTA-363E6.7 LL22NC03-32F9.1 DPPA3P1 XXbac- BPGBPG55C20.2 STX12RP11-172E9.2 YWHAEP5 TMEM258 RP11-244F12.2 AP001610.5 RN7SL130PRP4-533D7.5 CTB-12O2.1 MIR762HG SETP16 EIF4BP3 LYPLA2P1 RPS4XP17RPL29P14 GPR37L1 FAXC PEBP1P2 RP11-1167A19.6 RP5-864K19.7 RP11-67L3.5RP11-45M22.5 AC133633.1 STX3 P4HA3 AC017002.2 CTD-2313J17.7 UMODL1-AS1GCM1 OVOL3 HRASLS2 RP1-261G23.7 C16orf58 COL19A1 RP11-567F11.1RP4-584D14.6 RP1-63M2.5 RP11-584P21.2 MRPS27 RAPGEF1 MYH9 RP11-258F1.1RP1-80N2.3 RP11-356J5.12 MAPK3 WDR63 Metazoa_SRP RP11-973N13.4 SMIM15ZSCAN26 RP11-428G5.7 CTC-429P9.1 CTA-397H3.3 RP11-603J24.14 IGBP1P1RP11-50D9.4 RPL7P46 AC004237.1 EPHB2 AGT CELF1 CHCHD6 RP11-109L13.1 FZD4CTC-435M10.3 CC2D2B RP1-206D15.6 NPM1P19 RP11-445N20.2 DR1 SCARNA6LMNTD2 CEP135 RAI1 RPS10P18 FLT1 BCL2L11 AL021546.6 RP11-495P10.7FAR1-IT1 RP11-252O18.2 TLE6 MROH7-TTC4 CTD-3028N15.1 C16orf45 ANKRD40RP11-514P8.2 NPW RP11-459O16.8 SRSF12 NDRG2 SMPD1 RAP1AP RP3-414A15.11SH3BP4 RP11-531A24.5 AC100830.3 RP11-1060G2.1 KTN1-AS1 FBXL3 PRNCR1ZNF587B RP11-573D15.2 MCFD2 AC110769.3 ZNF702P RP11-25L3.1 RP11-303E16.7NIPAL4 AC018766.6 RPS15AP12 RP11-334E6.10 AC009120.10 RP11-104H15.10EEF2 Metazoa_SRP CPE COL28A1 AADAC RP5-1119A7.14 VDAC2P2 SPATS2L USP8P1SERPINA11 TXLNG AC079466.1 RP1-102H19.7 STAU2-AS1 YBX1 MBOAT2 GCOM2RPSAP13 RP11-17J14.2 RP11-405M12.4 MIR193BHG NAP1L4 TGFA RP11-274A11.3RN7SL851P SLC25A2 FAM221B NACC2 RP11-694I15.7 CTD-2008P7.1 FLNCRP11-162A12.4 AC096649.2 MCM3 CTD-2017C7.1 C10orf67 TUBA1B RP11-171I2.3AC003682.16 DDX59 AC011747.6 SNHG1 NOP14 CPS1 CTB-32O4.2 RP11-835E18.4RP13-487P22.1 AFM RP11-261P9.4 HR CTA-14H9.5 SEMA6B RN7SKP70RP11-111A21.1 MCOLN3 RP11-387H17.4 SDAD1 RP1-102K2.9 RP11-727F15.13AC093110.3 RP11-59H7.3 RP11-6D1.3 C16orf52 R3HDM1 RP11-34A14.3HDAC11-AS1 DPY19L1P1 LINC01234 RP4-794I6.4 RNF157 RLN1 RP11-326I19.2AC140725.4 CTC-325J23.2 AC021876.4 AC253572.1 RP11-557J10.4 LDHBP1TMEM121 PHLDA3 PLVAP PDXDC2P LINC01400 RPL7P9 CTB-55O6.13 LRRD1AC005154.8 PIK3R1 RP11-73M18.11 HMGB1P14 HTR3A VSNL1 RP11-84A19.4AL163953.3 PSMA7 RP11-697E22.2 RP11-38G5.2 TFG TRIM11 LMAN1L PHBP12TAS2R18 CNOT6L IGFBP3 EFNA1 C20orf196 AC006538.4 CH507-9B2.4 KCNE1AC012594.1 AC079779.6 IMPACT PTPN21 RBM38 RP13-977J11.6 CTD-2201E18.5GBP4 RP11-303E16.8 BHMG1 CTBP2P7 KLHL10 MYOF IGBP1 ZKSCAN3 CDC73 ILKAPRP11-351I24.1 ACTG1P15 IMPA1 CABP7 MIR3179-1 RPS15AP38 CTC-137K3.1SRGAP2 RP11-723O4.6 RP11-96D1.3 RP11-182N22.8 RP11-122G18.7 CTC-756D1.3AC009060.2 CHRM5 ANO10 MFHAS1 ABCC2 LL22NC03-24A12.9 DNAJA2 OPHN1 CCDC58SERPINE2 NDEL1 RP11-16E23.4 FAM234A RP4-593H12.1 ZFP69B RP11-9E13.4LA16c-OS12.2 RP11-426C22.5 CELF2-AS1 CTA-253N17.1 CCDC106 RP11-493L12.4AC009948.7 HMGB1P8 HECA UBE2J2 PCNPP5 TRAPPC8 FCGR2A PITPNM3 YPEL5P2FDPSP8 IDNK RP11-454L9.2 RP11-602N24.3 CYP2F1 EWSR1 RABGAP1L-IT1RP11-169E6.1 RPL14P3 UBA52P8 KCNV2 ADSL RP11-46F15.2 RBMX2 RP11-478C6.6PWAR1 ARAP1-AS2 RP11-214K3.5 NID2 RP11-45A17.3 HSFX1 GAS2L3 PHACTR3RPS17 PIK3R4 AC083843.2 KIZ-AS1 SARNP DES RP11-400N9.1 CRKL ULK4P2CTB-83J4.1 RP1-253P7.4 RP11-39C10.1 GREB1L HGD LINC01126 RPL13P6MIA-RAB4B SYPL2 KRT18P31 SP6 GPHA2 CYP4A22 E2F6P1 RENBP ACSM2B SHCBP1GRPEL2-AS1 RP11-262H14.3 TBC1D8 RPL14P1 LRRC19 RP11-120K18.2 GAPDHP2CTD-2619J13.27 CHRNA4 RNF152 RP11-109A6.3 RP11-516A11.1 TRAPPC13 MT1GTCTE1 RP11-66N5.2 WDR26 AC005082.12 CTD-2515A14.1 BIVM ADCK1RP11-299G20.5 PEBP1 CTD-2012K14.8 STRN AC009950.2 LLNLR-304A6.1EEF1A1P10 TRMT61B PPP1R37 GPR52 DOLPP1 CTD-2349P21.6 RP11-317P15.4 HADHBRP11-51J9.6 RPS6 TNFSF13B RN7SL535P FBLIM1 CD274 RP11-84C13.2RP1-288H2.2 SLC25A14P1 AC009245.3 EOMES RP11-395N3.1 SLC22A13 CDC42EP4CLDN9 GAS6 CENPCP1 SLC9A5 AC003104.1 GAPVD1 RP11-1250I15.2 AK4P3 PSMG2KLF1 AC099668.5 C11orf65 CFHR5 AC006160.5 MPRIP KIAA1468 UNC80 PREX1DNAH14 YWHAH NFE2L3P1 RP11-500B12.1 ASB13 CTD-2583A14.9 ELFN1RP11-45A17.2 ENPP7P8 SMAD3 FAM206A ZNF554 RP4-733B9.1 RP11-528I4.2 TEX15RP11-121C6.4 ARHGAP26 TCERG1 RP11-395A13.2 U2SURP TTC14 GJC2 PCDHGB9PFANCD2OS MBOAT4 CDV3 EIF2S3 CCDC53 RP11-344P13.3 WBP4 HIGD1B TNPO3FAM228B ACVR2B-AS1 ACSL4 RPL41P2 PARK7 GOLGA8T RP11-617B3.2RP11-427J23.1 RP4-785G19.5 RP11-767C1.2 KCNS3 FAM187A TOB2 WNT7B NEDD1ATMIN RP11-3D4.3 RP11-101E7.2 IFIT1P1 BLOC1S4 RP11-266L9.6 RFESDRP1-278E11.3 MORN4 KCTD3 LINC01088 ZNF705A KCNS1 RPL4 POLA1RP11-452H21.4 RPL36 CDRT1 BAIAP2 URGCP-MRPS24 RP11-166B2.5 PCDHGA3SLC30A3 RP11-50D9.3 RP11-692D12.1 WASF3 RPL30 FOXK1 NENFP1 THOC7 ABCE1SEC24C AC005534.8 HSP90AB2P MBP RP5-1050D4.4 ZMYND19P1 CHRM4RP11-523H24.3 ARNT2 DHX57 RP11-307P22.1 SERPINA4 FOXA3 AC023491.1AC007325.3 RP11-111H13.1 CDKN2A-AS1 RP4-669L17.8 ACE2 FBXO21 CARD9COMMD6 COASY ZNF622 XXbac- MUC20 BPG246D15.9 RP11-135A1.2 ZNF714MTATP6P1 HOXC6 GAPDHP48 RP11-687F6.5 CTB-102L5.7 KPNB1 RP11-304L19.3RP11-471B22.2 RP11-560A15.6 NUPR1 MARK2P9 AC105052.2 ZNF320 HMGB1P19RP11-295I5.3 RP11-155O18.6 MAPRE1 MLK7-AS1 NPM1P26 RP11-277P12.6IGLVIVOR22-1 EI24P2 RP11-305K5.1 ZCCHC14 RTN3P1 RP11-59C5.3 ZFAS1 DIS3RP11-498C9.4 RP3-426I6.2 MOXD1 AC009133.12 TDH RHOBTB2 DNAJC11RP5-981O7.2 OSR1 COX6B1 RP11-61L19.1 TRIM45 ADRBK2 PLCL1 MAN1A1 IQCA1MIR3180-2 MIR3180-3 HPCAL1 RP11-571F15.3 CSNK1G2-AS1 RPL12P6 AC093642.3U52111.14 RP11-357N13.6 GS1-166A23.2 RP11-973H7.3 RP11-141M1.3RP11-488P3.1 ADAMTS7 RNF34 SRRM1P3 GATSL2 ZNF17 RP11-277P12.9RP11-37B2.1 AZGP1 RP11-339B21.10 AL109927.1 CYP21A2 RP11-873E20.1AC010642.2 ISOC2 CTD-3037G24.4 CD163L1 ZSCAN12 NRARP LMOD3 AP003419.11RP11-90H3.1 NDUFS1 BTN2A2 SF3B6 GABRP AC004540.5 PCED1B HIST1H3PS1 EIF5ARUNDC3A-AS1 ANKRD20A3 UROD AGA IGLV1-51 TYW1B TRPM7 LRRC24 THAP11 AQP3HOTAIRM1 VAV1 AC001226.7 CCDC144B DNAJC9 RP11-369C8.1 RPL31P52 SCRT1RP11-380N8.7 TIMM23B FTH1P8 RPL7P23 UBA52 PROSER2-AS1 ST13P19RP11-736N17.4 OTUB2 GDPD5 NDST2 CTA-268H5.14 ZNF471 RP11-635N19.1 RAMP2LINC00264 WDR55 SERPINA6 PCDHA10 RP13-270P17.3 CSE1L-AS1 ADIRF CTSERP11-712B9.2 RP11-677M14.6 AGO2 RP11-244N20.7 PSMD13 RP11-384P7.7 NR5A1DENND6A LINC00907 GVQW1 CCDC13 FPR3 AC009303.1 RP11-261C10.7 GUSBP5LINC01036 ZNF593 RP11-1191J2.2 RAB17 CLPX CTD-2542C24.5 DCAF11 MAPK6PS3RP11-517C16.2 RP3-522J7.7 CTD-2516F10.2 LINC00857 RP5-1142A6.2 RPP14MUC19 NSD1 RP5-1049G16.4 G3BP2 GALNT13 KLF2P1 ATXN7 SYTL1 DYRK2RP11-647K16.1 AC104451.2 NDUFAB1 GBP3 MPND LYG1 RP3-465N24.6 RPS4Y1DAPK1 TMCO3 SSC4D DCTN3 KB-1572G7.3 MFSD1P1 AC007365.3 RP11-536C10.12CH17-262A2.1 TRGV3 HSPA8P5 SORD ATE1-AS1 ZMYND15 RP11-188P20.3 GPC2PHRF1 CTB-129O4.1 BANF1P3 DDX42 RP11-468E2.2 FAM193B RPL36A-HNRNPH2ZCCHC17 RN7SL273P RP11-550F7.1 HNRNPCP1 MSN RP11-126L15.4 UTP6 CRLF3YWHABP2 CEACAMP3 UBE2V1P2 RP11-295K2.3 ARHGAP31 RBMS3-AS2 FBXO34SEPSECS-AS1 VNN3 DENND1C WHSC1L1 PRR14 LFNG RPAP3 CTA-398F10.2 ACRV1LINC01270 ROMO1 TOX3 HIATL2 MYO1A NLRP4 POLN P3H4 RP11-473M20.16 JMJD1CLL22NC03-23C6.13 DAB2 RP11-421F16.3 MYADML2 LYPLA2 CCDC40 MED26 IPO4LINC00365 MCAM ZNF141 RP5-884G6.2 FOLR2 CTB-50L17.7 RP11-496I2.5AC026271.5 ATP1B3 LTBR MGC39584 SUMF2 RP11-384C4.2 DRC1 APOC1 THRAP3RP11-505P4.6 PKD2 PRKCA-AS1 RP11-244H3.4 THUMPD1 NPM1P27 PRKG1RP11-24I21.1 NUP98 RP11-252I14.2 MPRIPP1 PLAC4 CTD-2006C1.12CITF22-92A6.1 XKR6 RP11-843P14.2 RP11-199F11.2 SERF1A ZNF770 ZNF792DUTP6 HLA-V RP4-564F22.7 RP1-102E24.9 RUSC2 HMHA1 C16orf72 RP11-149F8.3KIF5B IGHV2-70 CCL27 PSMC2 HBA2 RP11-378A13.1 RANBP2 RP11-248B24.1RP11-1398P2.1 DCDC2B MAK16 RMI1 TRIM33 RN7SL263P LA16c-360H6.2 CHD1RP11-667M19.5 BMP7 SERPINA3 ANKRD31 CTD-2026K11.4 TMEM115 CLIC4P3 OGNDIDO1 RP11-89F3.2 ANKRD13D WFIKKN2 RP11-383G6.3 AC009014.3 RP4-695O20.1AC003005.4 PABPC1P3 PDLIM2 RP11-475E11.2 GJB2 RP13-20L14.6 RP11-255H23.4PEX7 RP11-26J3.3 NEDD9 RP11-349N19.2 GMEB2 RP1-212P9.3 HKDC1 EDA2R HDLBPZNF639 IGLV2-5 RP5-1142J19.2 NLRC5 PRSS33 FNIP1 RPL34P17 DNMT1 DONSONRP11-1348G14.5 NHS MEIS3 RP1-232L22_B.1 SOX15 HIGD2A ARF4P2 TMEM56 SMIM6CLTB CTD-2213F21.2 GTF2I LMF1-AS1 IFNA20P ZNF497 TGM2 C8orf37-AS1RP5-1125A11.6 COG6 MT-ATP8 IL10 SPDYE16 WNK1 AC006372.4 FPGSRP11-798G7.5 YTHDC2 AC004221.2 ATAD5 LENG8-AS1 EEF1G ADH5P4 MTRR AEBP2MRPS33P2 CSPG4 AC007161.5 RP11-616K22.1 LINC01419 TFF1 LINC00158RP4-665J23.1 RP11-685A21.1 HBA1 INHBC TTI2 YAE1D1 MRPL3 RP11-1376P16.2RP11-275I14.4 DPRXP4 SNHG11 NAA25 TCEB1 RP4-539M6.21 FKBP15 RP11-423H2.3COX5BP3 RP11-443P15.2 AC002075.4 CPEB2-AS1 VIM GPR35 RAVER1 ZNF853RP11-126K15.1 GS1-124K5.13 RP11-793I11.1 RAB5CP1 AP000640.10 CREB3L1ALOX15B AC007292.7 COL14A1 KIDINS220 AC005786.3 RP1-65P5.3 ANAPC5Z98744.1 RP11-146E13.5 RP11-326C3.7 ZNF148 STEAP1 KCNH6 GPRC5C CHRAC1RPL39P36 SNORA5C GLIS3 AC000041.8 STIM2 RP11-296K13.4 SNORA48 uc_338ABCA11P SEPT14P4 RP11-295D4.7 RNU2-11P ABHD15-AS1 SDS POMP FGD5CTD-2349P21.7 RP11-304M2.6 RP11-12A20.10 AC074117.13 ZAR1L ZFP69 AFF4RP11-4M23.3 HHIPL1 U3 RP13-582O9.7 CTC-204F22.1 RP11-455O6.5 HSP90AA2PRP11-85B7.5 SOX2OT_exon1 RP11-24J19.1 AC005838.2 C1QA TMEM127 SNORA45ASNORA2 SNORA49 RP3-365I19.2 CH17-232I21.1 MIR1248 BRCA2 RP11-792A8.3FAM155A KIAA1644 ABCA13 CDC42BPA RP11-66B24.7 CD24P4 CTD-2311M21.3ANGPTL1 SOX9 ANKRD20A8P SPATA31C2 KLHL34 RIMS1 RP5-998N21.4 GPR88 LINGO4BEND2 FAM83C GLP1R RP11-712C19.1 PARP1P1 SNX19P2 NR2F2 TARID GNG4 INSM1ABCB11 FOXI3 CXCL9 TNPO1P3 FER1L5 ICOS KCNA4 ERVMER34-1 CXCR1 CTAGE10PCTAGE11P CICP2 CLEC14A RP11-84A19.2 RP11-522N14.2 LINC00839 SLC9A3P3TRHDE RP11-742D12.2 CEBPA-AS1 TMEM78 AC092535.3 MAPK6PS4 RP11-305A4.3NOX3 FAM66B SDAD1P2 SULT4A1 C3orf80 RP11-389G6.3 LAMA4 SPRY4RP11-331G2.6 NDN MICAL2 KB-176G8.1 RP1-136J15.5 ELN RP11-190D6.1RP11-561O4.1 RP11-1216L17.1 MAATS1 RP11-769O8.1 TPD52L3 LINC01018 KLRG2GSX1 TIMP4 RP11-185E8.2 CYLC1 ZFP2 CTD-2535L24.2 RPL23AP92 RP11-59D5_B.2RP11-26J3.1 PLA1A AF064858.8 RP11-420O16.2 LL22NC03-84E4.11 PSMD12PBTBD10P1 CTD-2126E3.5 EPO CTD-2126E3.3 ADAD1 CTD-2651B20.1 RBBP4P5 PPICACTR3P2 RP11-350G24.2 IL1RN RP11-324E6.6 RP11-211N11.5 FLJ22447RPL21P132 HAO2 ANXA3 RP11-804M7.1 CEACAMP10 RAB32 EIF4A1P9 KCTD9P3KCTD9P1 RP11-259P15.4 POLR3GP1 NAP1L4P3 DSPP RP11-483G21.3 RP11-288C17.1CTC-512J14.7 HNRNPA1P26 REP15 FDPSP1 PRODH2 HMGA1P1 CTD-2331H12.5 ZNF41TCP10L2 RAET1G LINC00941 GAPDHP44 RP11-473M10.3 HCG4P11 AC104389.28RP11-510N19.5 RP11-761B3.1 AC073316.1 HNRNPA3P7 HMGN1P30 PLAC1 RBMX2P5AC068491.3 HSD17B1P1 MTND1P8 SMARCA5-AS1 OR4K7P CTD-2571L23.9 WDR82P1FRG1JP SPINK1 ESRRAP2 RP11-364P2.2 LINC01320 CNTNAP3P1 SLC25A5P2 SDCBPP3SDCBPP2 RP11-388B24.4 RP11-183G22.1 GPR79 NPM1P35 RP11-268P4.4RP11-346C16.2 AC064852.4 VDAC3P1 RP13-20L14.2 IGKV1OR9-2 XXbac- BMS1P8RP11-477J21.6 B476C20.10 RP1-202O8.3 LINC01169 MTND1P10 RP11-411B10.4PEX5L-AS1 CT45A10 ATP1B3P1 RPL37AP1 CTB-20D2.1 CTD-2528A14.3RP11-452K12.4 RP11-367H1.1 VGLL1 RN7SL221P RN7SL605P RP1-164L12.1 RPS4Y2AC007204.2 AC069363.1 RPS4XP22 RP11-778J16.2 AJ271736.10 AJ271736.10RPS4XP11 RP11-462L8.1 CDC42EP3P1 RBP7 RP1-302G2.5 RP11-197K6.1 RN7SKP266RPL34P21 RP11-467L19.8 RP11-109N23.6 TMEM31 RP11-63E16.1 RN7SL502PRP11-982M15.5 RPL7P34 SNCG RP13-714J12.1 RN7SKP57 GTF2IP2 CLYBL-AS2BCRP1 RP3-412A9.15 AP000282.2 RP11-650K20.3 RP11-486P11.1 RP11-458F8.1RN7SL799P MRPS36P4 ZNF444P1 SMR3A RN7SL745P RP11-365H23.1 RP11-556O5.6SNHG10 RP11-174G6.1 RP11-478H16.1 RP11-256L6.2 Metazoa_SRP AC016722.3RP1-310O13.13 RP11-219G10.1 AC010884.1 RN7SL128P RP11-627J17.1 AK4P5PEX5L-AS2 RP11-195C7.2 RP11-686D22.7 LLPH-AS1 LDHAP5 RP11-325L12.7RPL9P32 RP11-344P13.4 CTB-70D19.1 CTD-2595P9.4 CTD-3110H11.1RP1-102G20.5 RP11-736E3.1 RP1-273G13.2 RP11-90D4.3 IGHA1 CTD-2583A14.1HMGB3P6 HMGN1P35 RP11-411G7.2 RP11-599B13.8 RPL19P21 RP11-669B18.1RP11-35J10.5 CTD-2207O23.12 H2AFB1 Metazoa_SRP RN7SKP292 NUDT19P4RP11-527F13.1 HOXC-AS1 AC011933.2 RP11-93O14.2 RP4-612C19.1 RP5-1018K9.1AP001464.4 IGKV2-23 AC004837.3 AF127577.10 RP11-483P21.2 RP5-940J5.8RP11-325K19.1 IGKV1-22 AC007272.3 RP11-407A16.3 RP1-27K12.4 RP11-19J5.2RP11-573D15.1 CTD-2568A17.1 RPL17P46 RP3-343K2.4 CTD-2358C21.3RP11-34P1.2 COX8C RP11-10N23.5 RPS12P27 HOTTIP_3 Z69890.1 CTD-2105E13.16VPS13A-AS1 RPL12P21 MTND3P10 CTD-2538C1.3 CTB-102L5.4 PTMAP4 AL450992.2AC015936.3 RP11-232D9.1 NCOA7-AS1 RP11-288E14.2 ST6GALNAC4P1 RP11-74C1.2FAM83C-AS1 RP11-16F15.4 RP11-474I11.8 CFL1P6 LINC01545 RP11-301G21.1RP11-203M5.8 RP11-95I19.2 RPL21P134 RP11-672L10.6 RPSAP14 RP11-254G11.1AF213884.2 RP11-49K24.3 AC006373.1 AC006116.14 RP11-493L12.6RP11-813P10.2 RP11-387D10.4 PPIAP32 RPS27AP1 GTSCR1 RP11-611O2.2RP11-542G1.1 RP11-316M1.3 RP11-476B13.2 EIF5AP4 RP11-874G11.1CTD-2609K8.3 CTD-2288F12.1 CTD-2538G9.5 CTC-459M5.1 RP11-554E23.4HOTTIP_2 PTRH2 A2ML1-AS1 RP11-508M8.1 IGKV1-27 RP11-194G10.3CTD-2529O21.1 CTB-52I2.7 LINC00555 IGLV1-62 RPS15AP6 RP11-613E4.4RP11-476H20.1 RPS24P18 CCDC58P5 AC008074.5 RP11-49O14.3 RP11-243M5.1AC015849.12 ZDHHC20P1 RP13-444K19.1 RP11-21M24.3 PRR13P2 RP3-333H23.9RP11-54O7.14 CTD-2287O16.3 AC011290.4 CTD-2623N2.5 RP13-49I15.6 DPPA2RN7SL176P RPL23AP1 LINC01123 SYNJ2BP-COX16 IL15RA RP11-327P2.5 RPL35APRPF4B RPS27A RN7SL573P C19orf53 POPDC2 LHX6 RP11-175O19.4 bP-21264C1.1PRPS1 CSNK2B PTGIS TMEM116 RP5-875H18.4 ANXA7 TRAPPC6A RP11-274E7.2UROC1 IL17RD OLA1 TRHR AC068831.3 IGHVII-30-1 SUV39H1 TMEM27 BLOC1S5AP001062.8 CTC-548K16.2 PCDHGB7 RP11-863K10.7 FABP12 LA16c-425C2.1RNASEH2B-AS1 GID8 ZNF358 OPLAH PAIP1 RP11-444E17.6 STAB2 CPD UBXN10OR2D2 TSEN2 ZNF192P1 DNAJC2 CD4 FAM131C TBC1D3K IFNLR1 UQCRQRP11-452L6.6 SYMPK RASSF8 KDM4C RP11-123K3.4 RP11-717K11.2 RP11-161M6.6AC009237.8 OSBPL10-AS1 RP11-196B3.1 MMP14 GLUD1P3 JPH4 RP11-1000B6.5MKNK1-AS1 RP11-287D1.3 CHODL ASXL1 TSPAN14 USP32P2 FCER2 XPO5 PLAGL2SLC5A2 ATAD2B SSSCA1 GNAL BRWD3 RHOB WNT9A ARAP3 CD1B GNLY ENO1-AS1AC105393.2 ARMC10P1 RP11-1334A24.5 RP13-638C3.3 XPNPEP2 RASSF4 PMS2P9KLF11 PLCG1-AS1 RP1-232P20.1 MVD RP11-457M11.7 AC002128.5 OXCT2P1RP11-3D23.1 RP11-1143G9.5 RP11-59H7.4 KBTBD6 ORM1 RP5-1171I10.5RDH10-AS1 ODCP RP11-567P19.1 LL09NC01-139C3.1 RP11-170M17.2 PER1 DRAM1WDHD1 RP11-165N19.2 IGKV1-8 CTD-3193O13.8 RP11-148K1.10 RP11-661O13.1FTO-IT1 ACTG2 SPATA2L EFCAB8 ZBTB6 RP11-73M18.7 CLLU1OS NXPH3 TMA16 UCK1C9orf173-AS1 RP1-40E16.12 KRT19 KPNA3 LINC00664 SLA2 VAMP5 MCUR1RP3-496C20.1 PRELID1P4 RPL23AP95 TPP2 ASB7 RP11-214K3.19 TSPO PTTG2 CHMLPIPOX CHMP1A TFF2 PCSK4 CTD-3074O7.11 PRSS36 PHF12 RHNO1 HIST1H2BIHSP90AA4P MYO7A RP4-605O3.4 Z95114.7 ADAMTSL5 NBR1 AJUBA AD000684.2 DDI2GSTA4 ACSM2A ZNF165 TTI1 DDX18P5 CTA-38K21.2 XIAP RBMXL2 RP11-142A22.3B3GALNT1 MICD CH507-513H4.5 MTHFD2 PLEKHN1 CTAGE5 MON1B RP11-770E5.1LINC01002 UBTF RP11-293I14.2 AC125232.1 ZNF254 RP5-1039K5.13 IGKV1D-22MANSC1 SNORD3A SNRK CTD-2369P2.8 HMGB1P31 TMEM55B ZHX1 H2AFY COL1A2AC092580.3 SYNRG ZNF737 RP11-235E17.3 RP11-45M22.3 IFNNP1 RP11-129M16.4RP11-196B3.4 GMPR AARSD1 PLK5 RP11-121C6.5 RP11-248J18.3 RP13-36G14.4TNFAIP8L1 RP11-535A19.2 LINC00632 RASA1 PSENEN RP11-649E7.7 CTA-212A2.1AC005220.3 AC092295.4 PSMD6 RP4-613A2.1 C11orf72 LCP2 UBA5 RP11-153F10.2RP11-196G11.6 RP11-438L19.1 RP11-417P24.1 KCTD14 TPI1 SULT1C2 RPS3AP26QRICH1 PSMD8 CTD-2026D20.2 GYPC ESPNP RP11-468E2.6 SLC52A2 NCKIPSDPM20D1 GBAS AC017101.10 CTC-276P9.4 RP11-755O11.2 RP11-161I2.1 HAUS4KRTAP5-9 MED28P1 SNORD15B DLG3-AS1 DOCK11 SLC20A1 RP11-269M20.3 FAM96BRP11-196B3.2 MID1IP1 CEP57L1 CTB-134H23.3 CFAP47 RP11-6O2.3 CICP8RP11-428P16.2 SPZ1 C17orf50 LIPI AC092620.2 TASP1 RPL37A RP11-298C3.2RP11-848P1.3 PPIA RP11-403I13.7 NPPA AC104297.1 RP11-419I17.1 MTX1P1C10orf25 AF015262.2 RP11-132A1.4 KCNMB3P1 CALCRL IBTK ABTB1 RPS24P8RP11-762H8.4 RP11-384K6.6 VRK3 PPID RP13-314C10.5 ING2 DNAJB13 PRKRIRP7IL5 RP11-195F19.30 IMPDH1P10 CSRP2BP PGAM1P7 RP11-235E17.5 TXNDC16AC026248.1 TRUB2 RP11-362F19.1 NUP205 AC004019.13 RP11-521C20.2 DLX2GTPBP4 CTD-3148110.9 GAPDHP42 RPL5P29 SSSCA1-AS1 CTC-543D15.1 LINC00346CTAGE1 LINC01220 LAGE3 JMJD7 NHSL2 AC097724.3 FRGCA CAPS UVRAG HEATR9SLC2A6 CREM RN7SKP287 MED29 CTB-33G10.6 ERRFI1 C11orf52 AGAP11 RN7SL657PNFKBIL1 TPO ART4 TXNDC9 RP11-452H21.1 APITD1 GSDMC MIR3681HGCTD-3222D19.2 RP11-398A8.5 TYW1 FAM133DP CSNK1A1P1 CFAP54 PSMB3 MAP3K3RNASE1 ANKRD53 RP11-680A11.5 KRAS PGM5P2 FAM71E1 GGTA1P AKIRIN1LINC00384 LILRB2 LLNLR-268E12.1 RAD17 RP11-783K16.14 HIPK1-AS1 UBE2MP1PDE4DIPP1 ZCCHC24 SRSF9 TEX2 RP11-348N5.7 HIST1H1D NLE1 SGSM3 FBXO33AFF2-IT1 DDX50P1 FNBP1P1 GNL3L TAF10 RP11-418H16.1 AKAP1 NME1 AC137934.1VNN1 HSD11B1 TPCN2 PLA2G2A UBE2Z AMDHD1 PDP2 APOC4 AC015849.14 POLR3ARP11-432B6.1 CDK16 LINC00698 LA16c-431H6.7 RP11-791G16.2 SDHAP3 GLT8D1FTCD POM121 SLC35A5 EFTUD2 TMEM262 LGALS9B TMEM54 YBX1P4 AKAP6 SF3A1ALOXE3 SLC19A1 CNPPD1 MRPL37P1 LA16c-313D11.9 RP11-690I21.3 MAPKAP1ZSCAN18 SERTAD3 RP11-1007O24.2 PYCR2 HPX SLC12A1 F10 BCL2L14RP11-123K3.9 RASSF3 RP11-697E2.11 SNHG12 RP11-465N4.4 EDEM1 RPL7AP31PRKAR1B DANCR VTN GPX1P1 RP11-425L10.1 GDNF-AS1 RP11-498C9.2 ERCC8 PRMT1EIF3M CTNNA3 NFRKB CEACAM6 CTC-250P20.2 PAPPA2 SPATS2 AC092597.3 SENP2RP4-778K6.3 DCTN6 STK24-AS1 URB2 COX6CP1 MED27 TMPRSS4 bP-21264C1.2RP11-624C23.1 C11orf57 RQCD1 RP11-629N8.4 EXOSC9 RPLP1 FBXO31 CCDC109BEPHA3 C4BPA ANKMY2 PI4KA OXER1 RP11-486A14.2 MLXIP RP5-884M6.1 RPL3P4RP11-829H16.3 DDX39A RP11-770J1.4 RSRC1 IL11 RP11-371I20.2 CARF GRIK1LINC01341 NCOA7 RNASEH1 SLC2A12 CHST9 CYP4A11 WDR88 TATDN2 POFUT1 RRP36RP11-333J10.3 SNHG22 RIMBP3C FEZ2 DHX33 WASH5P RN7SL425P RP11-341G23.4CLDN5 PIWIL2 GCK RP11-425M5.7 SNX18P8 C5orf63 LINC00880 NFAM1 POP5SYNPO2L AGXT RP11-267N12.1 RP11-493E12.1 SYP PEG3 LARP4 RP11-762I7.4RANP1 AC137932.6 MYO1B LINC01481 ZNF324 USP42 RP4-725K1.1 ASB16RP11-264B17.2 RPS10P3 CTD-2358C21.4 RP4-800M22.1 EXOC3-AS1 LTC4SRP3-342P20.2 LYPD6 DLG2 TTC27 CSMD1 RP11-1008C21.1 RPA4 CSNK1G1 PDZD3RP3-368A4.6 RP11-644F5.11 ZNF283 CTC-336P14.1 RP11-875O11.3 RP1-199J3.6RP13-977J11.8 AKAP13 RPL5P1 KCMF1 CACYBPP3 CTB-75G16.3 RP11-285E9.6EXOC8 LA16c-380H5.6 FAM126B RP11-804A23.2 RP11-864J10.2 UBE2V1 SLC34A1M1AP RP11-295I5.4 SYCP2L AC093107.7 CICP9 RAB33A HNRNPA1P8 PEX11AATP5A1P3 NEAT1_3 ZDHHC20 PSMA6 SERPINB9P1 NUP133 STAT3 CDC25B ADH6GOLGA2P5 RP5-971N18.3 SKAP2 RP11-886P16.10 RP11-177H2.2 AC007326.1 LHBCHMP2A AC073342.12 RP11-423G4.10 CTD-3126B10.4 RP11-20I23.11 HNRNPA1P53TRA2B MRPS18AP1 MLYCD CREB3 CARM1 NUFIP1 ZNF823 RP11-304L19.1RP11-261C10.5 RP11-810M2.2 ALMS1P GTPBP8 AC159540.1 CTD-2021A8.2 IL23RMGC45922 RP11-544I20.2 LARP1P1 TMEM14DP ARHGEF28 RBM34 RP11-77H9.5 HPRGPX8 SGK223 CTD-2023M8.1 AC006994.3 RP11-359P18.1 CFHR2 PRR34RP11-376O6.2 SUPT4H1P1 RP11-33B1.3 CTD-2325P2.4 MRPS36P1 PGBD5RP11-451F14.1 THRSP CBX1P1 GATM-AS1 AP006621.5 KIF13A CCDC68 CDRT4 FOXL1RP1-59D14.1 TRAV36DV7 PKNOX1 RP4-678D15.1 TUBB8P7 TRIP13 SPEF2 GTF2H2CMVB12B CDO1 CDC40 ASH1L-IT1 SETP17 RP11-669N7.2 RPSAP11 RPS6P25 FCF1P5GMPS SEC24A XXyac-YX155B6.7 ZNF620 KLF3-AS1 XXbac- SIK2 PMEPA1RP13-228J13.8 TMC7 BPG181M17.5 NDUFS8 NR0B2 RP3-354N19.3 C1DP5AC005329.7 RPSAP72 SSR4 ZNF300 RP5-1024G6.2 RN7SL521P B3GALT2RP11-254F7.4 COL15A1 WFDC3 AP000560.3 LY6G5B KIAA1143 SLC25A5RP11-848P1.7 RP11-303E16.3 RP5-1042K10.10 AC007381.3 RP11-4B14.3RP11-872J21.3 AP2M1 SPICE1 GTF2IP14 SGOL1-AS1 RP11-149I2.4 TRAF4 KLK2RORA-AS1 PDIK1L SPTAN1 RP11-284H18.1 RP11-77G23.5 PITPNA-AS1 BCDIN3D-AS1LL0XNC01-36H8.1 TRA2A RP11-234O6.2 RP11-52A20.2 NSUN4 PALMD C2orf72IMPDH1P6 UBE2V2P3 FXYD5 DHRSX-IT1 DHRSX-IT1 BTBD2 ARPP19 C9orf69PDCD6IPP2 SLC5A9 SMIM1 RP11-546K22.3 ANGPTL2 RN7SL663P RP11-629O1.2CIRH1A RP11-91P24.5 RP11-386M24.3 VHL FSCN1 AC008746.10 CLIC1P1 NREPDOCK4-AS1 OAZ1 ATP13A4-AS1 FGL1 LINC01134 ZNF333 CTD-2562J17.6RP11-144O23.22 ZNF518A RP11-63G10.3 LINC00563 MANEA PGRMC2 CICP20 NPRL3ENTPD3 CTD-2527I21.5 AP000593.7 CTD-2620I22.2 AC000095.9 RPL21P3 ZNF830PRADC1 ZNF567 AURKA KHSRPP1 AL135745.1 AC002400.1 ZNF397 TWF1P1 PCDHB7SNRPA1 AC005363.11 MEIS1 AC009120.5 RP11-660M5.1 CHMP7 FAM187B2P FXNP2ACOT8 MYL6BP1 ACOT12 TANGO6 INHBE DUS1L SOX5 CFAP44-AS1 UCP3 AC016708.2SMAD4 RP11-56B16.1 LSM4 ARRDC5 EIF4H MAFG ALYREF RP5-937E21.8 CAMK2GPTMAP1 MS4A14 AC012512.1 C15orf52 AC017081.1 RIOK1 RP11-797D24.3RP11-20G6.1 PTP4A1P3 FAM181A PATL1 RNU2-6P ASPDH WDR82 ARGLU1 PRSS2RPL37P2 RGPD8 PTPRE MAP3K7 SCOC THPO RPL3P2 TMEM243 CTD-2224J9.8CTD-2553L13.9 TULP4 RBM14-RBM4 ZNF45 AC004538.3 RP11-455B3.1 HCFC1R1TMED10P1 HRAS FTH1P20 SHMT1P1 RPL7AP15 CCHCR1 RP11-589P10.7 RP11-330H6.5RP11-162A12.3 C11orf73 LTV1 SELP RP11-162G10.5 CLDN1 TMEM110-MUSTN1RP3-340B19.2 AC005954.4 TBC1D20 RN7SKP23 MYO15A RP11-234A1.1 PDIA5HEATR4 AC141586.5 RP11-388M20.1 MEF2C-AS1 PMPCB MDM2 RP11-834C11.10RP11-498M15.1 NOL8 NRAS ITIH1 SLC2A3 RP11-384L8.1 RP11-423H2.1KB-1732A1.1 ISLR2 DDX18P1 RAD1P1 RP11-175P19.2 GABARAPL2 VN1R1 CPSF3MRPL27 PGBD3 KNOP1P2 CISH COX5B FBXO8 LINC00261 MICAL3 RP11-34F13.3CLTCL1 TMEM241 PPAT USP22 USB1 FAM86EP RFXAP ZNF107 EPRS PDS5A TRABDKRT18P15 GLE1 OSBPL7 RPL23AP20 CAB39L RP11-203B9.4 TTC12 CTD-2008P7.8ENDOU RP11-440L14.1 SNORD3C RSBN1L TRAPPC6B ZNF695 SRSF10P1 CBL RPL21P7DDX19B C6orf99 FGFR3 MOCS3 AKR1C2 RP11-348N5.9 RP11-89C3.3 GOLGB1 CPNE9LSAMP NOP10 RP11-570G20.1 RP11-327F22.2 GRIN3B BHMT2 MIR4432HG PRRC1MAT2A GPR3 RP11-344B5.2 SPTLC1P1 RP11-1148L6.5 NAP1L1P1 TAC4 HSF5 ASB6SPDYE15P SLC29A3 LIPC NPY6R IGKV2OR2-7 IGKV2OR2-7D TEX14 CFAP58-AS1GMCL1 CTD-2308B18.1 LRBA MMAA RP11-51F16.8 CD200R1 AL021807.1RP11-618P17.4 CYTH2 AGGF1 ANOS2P ZBTB3 NAT6 CD83 UQCC3 CRYZL1RP11-435I10.4 MT1P1 SLC43A2 LTK AF146191.4 PXDNL AP000266.7 POLR2HCTD-3149D2.4 FAM114A2 RP11-138B4.1 ZNF628 ERGIC3 FAM184B DNAJC27-AS1RP11-685M7.3 VSX2 PSMC1P5 LDLRAD4-AS1 PAK6 RP3-370M22.8 CTB-134H23.2UQCRH POM121L8P MYO5BP2 RP11-875O11.2 ITIH5 XXbac- FASTKD5 B444P24.10RP1-149C7.1 OR5BA1P CH17-270A2.2 RP11-38J22.1 RP11-380I10.2 ATP5C1P1RPL5P22 HNRNPA1P44 HOTAIRM1_1 AC011284.3 C11orf74 RP11-624L4.1Metazoa_SRP RP11-731C17.1 CTC-505O3.3 ALKBH2 HIST1H1A SEPHS1P6 PCSK6-AS1PRRT3-AS1 RP11-173P15.7 RP11-77O7.1 CH17-478G19.2 RP11-799M12.2CTC-534B23.1 SPG21 AC068522.4 RPL21P120 IGKV2-26 PSMD10P3 DNM1P38IGHV1-3 RP11-573G6.8 RP11-881M11.1 RP11-696F12.1 RP11-91H12.1CTD-2561J22.5 RP11-674E16.1 RP11-1057B6.1 TSPAN5 RP1-93H18.6 BZW1RP11-767N6.7 ARFGAP2 CALR ABCG5 XPO1 PRKAB1 MRPS31P2 C4B EXOSC5AC079922.3 CTD-2589H19.6 ZFYVE19 RRM2P3 ZNF200 LSM10 MFAP1P1CTC-1337H24.3 EIF4A1P5 MGAT4B RP11-498P14.3 SLC6A8 RP11-552M6.1 ZNF483VAMP7 VAMP7 PRMT5 IGFLR1 TMEM94 ACTG1P4 CDK5RAP1 RP11-257O5.2 AKAP8MIEF1 AC006946.12 RP5-1174N9.2 RP11-264M12.2 PLA2G4E TTLL8 HK2 TERF1P5RP11-166O4.4 RP11-426C22.6 CYB5R3 CCDC69 KANSL3 EPHA10 CHRNA1 ZNF79CTB-131K11.1 CTD-2228K2.1 TTC7B RP11-626G11.3 TAF1A-AS1 HNRNPA3RP11-96O20.4 S100P RP11-432F4.2 CTD-3088G3.8 FAM216A RP11-10H3.1 SDHAP1GCHFR ARHGEF17 MIR22HG SRSF9P1 PNMT KIF21A RP1-149A16.3 CCDC84 RN7SKP175NAA15 RP11-179H18.5 SGK2 DPPA4 CTD-2583A14.8 COA1 PACSIN2 RP11-250B2.5CTD-2542L18.1 ZNF2 RP11-778D9.12 KLHL8 TIPIN IGHG4 POU5F2 LINC00891RBM45 RP11-395L14.18 CTC-1337H24.4 MPHOSPH10 SCN11A LYZ RP11-1070N10.7KB-1440D3.14 LIPT1 ARMCX3 RP11-778D9.13 ADCY9 MLLT1 ST13P13RP11-108O10.2 RPS12P28 GPR62 RP11-715J22.6 CTD-3001H11.2 RP11-30P6.1MAGEA9B KRT18P7 RP11-701H24.5 ACP1 PAXBP1-AS1 PALM IBA57-AS1RP11-328P23.3 TJP1 KLRB1 PTCH2 KCNK4 YIPF1 RALBP1 WNT4 AKR1A1 QRSL1CTD-2528L19.4 RP5-1139I1.2 TPD52L1 POLR1E CTB-58E17.3 RP11-736K20.6 LAP3SMC6 SH3BP5L AC009133.17 RPL7 ZNF674-AS1 CCDC71 ZYG11A RP11-178D12.2SPATA2 RP3-425P12.4 LL22NC03-2H8.4 CCDC34 RP11-497G19.2 GIMAP4 TUNARP2RY1 RUNX1 RP11-1006G14.1 RP11-171I2.1 PRR14L MRPL35P3 RP11-30L15.6MTRNR2L4 CPSF1 CHCHD1 RP11-649A18.3 RP11-295G24.4 RP11-165M1.1 CEP170CYP4F11 RP11-800A3.3 DDX51 AC013460.1 RP11-626E13.1 MYCT1 RP11-297C4.2GGTLC2 AC004449.6 CCT8 MTMR12 GFRA3 RP11-533F5.2 MYOZ2 GOT2P3 RNF181SNORA84 LINC00618 ITGAM RPS14 AC000095.11 COPS7B DNM2 AC009299.2 ATP13A2DNAJC3-AS1 AC022405.1 AC010412.1 DBIL5P RN7SL650P GPAM SF3A3P2 C1orf127RP11-905K4.1 KIF17 AC006272.1 CABP1 AP000892.4 SLC12A6 TCEA1P4RP11-386G11.5 RPL13 TMEM203 OR2W6P FNDC1 FAM35CP Metazoa_SRP POLE3MAN1C1 RP5-965G21.6 RIMKLA RP11-383B4.4 CPOX CHST14 RP11-728G15.1RP11-129G17.2 FAM76A RP4-740C4.7 RP11-34E5.4 CTC-344H19.4 CCDC93RP11-44F14.5 CACNB4 RUVBL1 LINC01535 RP11-512F24.1 USP37 FXN GLRA1 E4F1TNFRSF11A PSORS1C1 RPSAP69 ZDHHC9 ANKRD30BP2 RP11-122M14.1 RP11-602M11.4GTF3C2 RPS21 SPEF1 RPL7L1P8 RPL9 ENPP4 CTD-2026K11.5 IGHV3-73 RASL11BPSMD10P2 KIAA1191 TNS2 METTL5 RP11-325E14.5 SEC11C RP13-258O15.1RP11-378A13.2 ZBTB12P1 CTD-2619J13.3 WSB1 VAPA LYSMD4 APOA1 NUDT21 VPS36BTBD19 PFN1P1 ILF3 RP11-364L4.1 ANAPC2 ELOVL2 RP11-490N5.3 TMEM9B FAM3C2WEE1 RP11-54O15.3 AF129075.5 DRAIC RP11-400F19.12 JUNB RP11-573M3.2 ORC3RBM7 GK5 GDPD2 STK17A RP11-146N23.1 MGAT5B RP11-115N12.1 AC006014.7TRIAP1 FERMT3 PTPRN GJA1P1 IAH1 CCT6P1 PSMB7 CALM3 C19orf73 TM4SF19NUTM2E VWA3B RPL29P12 RP11-11C20.3 EPS15 RP11-587D21.1 TP53I3 ERCC3RP11-49K24.8 RP3-415N12.1 LSM3 FARSB PHF14 CCAR2 ZYG11B FAM200B ZNF764LRRC17 RP11-455J15.1 RP5-915N17.11 POP7 RP11-374M1.2 PKD1P6 FAM172BPABCB7 FLT3 CDC37 ZNRF1 RP11-295G20.2 AP000280.66 GLIS2 GEMIN4 POLR2BCTA-384D8.34 DDX18 C14orf159 CTD-2619J13.23 MYD88 LA16c-385E7.1MLLT4-AS1 RP11-298I3.4 RP11-681L4.2 RPL32P26 BCAP29 RP11-113K21.6RP1-89D4.1 TDGP1 MTND5P14 PRELID3B GEMIN5 DIP2A-IT1 DNAJB12 IGHV3-71GAS8-AS1 GNRH2 SMIM8 FTH1P1 AIFM3 CTAGE6 OGFOD3 RP11-119F19.4 ZNF699PLEKHO2 LMAN2 RP3-414A15.12 MASP2 SLC8A2 IGHV3-30 Metazoa_SRP OR2C1ATP8B5P CTD-2035E11.4 NDRG4 CTD-2286N8.2 FOXD1 YBX2 MRPS26 OR7D2 CLEC2BPXN-AS1 PDLIM7 NRTN BOLA2P2 AGRN DEPTOR RP11-386I23.1 LAMTOR5 DNM1P35PAWR STT3A DAPP1 DDN FAM133CP LINC01587 FAM41C AC011558.5 CDKN2A ITM2ATMOD3 AC092192.1 SOCS2 RBPMS2 RP11-355F16.1 PPEF1 RP5-1021I20.2 YWHAZP2RP11-1070A24.2 RAC2 RPS2P41 FLJ26850 RP11-1000B6.3 RP11-615J4.4 CFAP99MTND4P14 RP11-680F20.12 BCL2L10 RPS26P6 PARP4P2 RINT1 CTC-498J12.3ZNHIT2 CBX3P4 FAM213B SEC61A2 MKRN1 NUP50 LINC00612 UBE2A RP11-120K19.4RP11-264B17.5 USP47 RP11-617F23.2 WNT16 RP11-367G18.1 RP11-81A22.4IER3IP1 LVRN C10orf71-AS1 RP11-38L15.8 BNIP3P17 CH17-264L24.1 ATP5D DSTAC005251.3 RP11-124N2.1 MTX3 PABPC1P4 CMYA5 RP11-608O8.2 OR2A4RP11-446H18.5 DDX55P1 RP11-104H15.7 RPL22 RP11-131L12.4 CTD-2015H6.3ZC3H7B LSG1 CPB2-AS1 RP11-111A22.1 RP11-1012A1.4 GSTM4 RPGRIP1 DPF2RP11-383C5.5 RP11-627K11.6 RN7SL798P CTD-3194G12.2 CTD-2283N19.1 C2orf61AC005943.6 RPL23AP67 PLAC8L1 RBCK1 RP11-454K7.3 DPY19L2P1 RPL7P49CTD-2515O10.5 RP11-18B3.2 STX19 DSG2 RP5-951N9.1 RP5-963E22.6 DGCR6LRP11-365N19.2 SLC25A6 SLC25A6 HIST1H1PS1 TAS2R30 RP11-895M11.3 CXCL11LXN RP11-15J22.8 ZNF587 REEP3 SH2D4B TUBB1 HDDC2 EHD4-AS1 KCTD9P4 PRC1RP11-290H9.2 AMZ2P1 FAM86B1 IGLC4 SPATA17 C19orf66 RP11-413M3.4 RPL5P12RP11-340I6.6 PWWP2B RP11-707G14.8 PLSCR2 CISD3 APOA1-AS AC008985.1 ESPNHSP90B1 RP11-58K22.5 SNORA18 RP11-170N16.3 RPS7P11 RP3-414A15.10RP11-314A20.5 ZMAT5 MFSD10 CTD-3035K23.6 TRIM50 FRG1CP RP11-726G23.10CTD-2013N17.1 CELF6 GALNT16 TRAPPC11 ITGA11 LYPLAL1-AS1 CTC-492K19.7SPRYD4 PLIN1 RP1-102E24.10 RP11-16K12.2 MTHFD1 PPM1B DESI2 RP11-159F24.5RP11-154D6.1 AC091633.3 BX255923.3 RP11-756H6.1 RP11-23J18.1 EPX CERKRTKN RP11-637O19.3 CTB-102L5.8 CTD-2588C8.8 PC GTF3C4 RP11-98D18.9SORD2P RP11-446H18.1 LPGAT1 SNRPB RP11-443B7.3 RP11-507K13.6 RNASE10KRT17P8 CDC16 RP13-228J13.1 AC093616.4 ARHGEF12 NCL SCG2 RP11-302F12.10CTC-246B18.8 AC006538.8 TUBB7P ARHGAP33 SNX15 AP3B2 CTC-448F2.4 SFNKIRREL FAU KCNH3 RP5-864K19.6 RP5-892K4.1 RP11-777B9.1 PFN1P4Metazoa_SRP RP11-326L17.1 RP11-568J23.1 HLA-DQA2 BCL2L12P1 ZNF92P3RP13-88F20.1 RP11-311D14.1 CASP6 RP11-563N6.6 RP11-152H18.4 AP006621.6FOXD4L4 RP11-861E21.3 MIXL1 CHMP2B RP3-461P17.10 AC004951.6 CTD-2199O4.6DIO1 LINC00571 PDZD7 RAB38 RP11-517P14.7 MIEN1 CTD-2616J11.2 RFPL4AOR1J1 OFD1P17 CIITA RP11-64K12.8 OR2B6 SAAL1 HAAO PAAF1 FAM86B2 TDGF1P5RP11-549B18.1 REEP6 AC008982.2 RP11-114H24.6 FUT11 PPM1G RP11-430H10.1RNF215 PLCB3 GRAP2 RP11-671E7.1 FER1L4 FKBPL RP11-793H13.11 CTB-35F21.3OR2A7 ZCCHC12 SNX4 LL09NC01-251B2.3 TBC1D16 RP11-83A24.2 CALHM1 MTCO3P12Z95114.6 RP11-334J6.7 EEF1A1P9 UBE2FP3 UBLCP1 RPL7L1P9 MARCKSL1P1RP11-379B18.5 FAM103A2P ZNF670 MSRB2 POTEA AC006378.2 TYSND1 ZBTB7AHNRNPAB LARP1B KANK2 ATP8A2P2 TTC21A RP11-432I5.4 RP11-144C15.2 PRSS12RP11-546J1.1 PPIAP3 RPS8 NELFE RP5-1065J22.4 VWA3A SHANK3 RP11-14N7.2HSD11B2 THUMPD3 RP11-384M20.1 FAM101B RP11-493P1.2 MCRS1 RYKP1 NAB1RP11-631M6.2 PRR11 LINC01436 FER1L6 SNTB2 YRDCP1 TDG HNRNPA1P45RN7SKP225 RP11-3D4.2 CH507-145C22.1 GP5 RP11-197P3.5 CRYL1 CNOT1 SH3GL1TMEM230 ZCCHC2 WWTR1 TSPAN1 NFYC MIER1 RWDD4P2 NBAS CTD-3051D23.1 SRSF4RP11-90P5.5 FOXM1 RP13-126P21.2 C1orf229 RP11-423H2.4 RP11-672A2.6TRAPPC3 RP11-876N24.5 STK35 RAB1C PPP2R4 C12orf50 RP11-47G11.2RP4-539M6.20 ZNF638 CTC-459F4.6 RP11-105C19.2 RP11-356B19.11 LINC00551PPIL1 MT1F UHRF2P1 RPL19 RP11-4B16.4 RAB4B-EGLN2 RP11-804H8.6 CCDC116HSPA8P19 KIF1BP RP11-447L10.1 AC004878.2 RPL23AP55 ZNF24 RP11-146E13.4CCDC155 ALG3P1 ADPRHL2 RP11-561O23.9 HLA-C OR6S1 LINC00271 TADA2A ANTXRLATG12 AP000662.9 KIF24 FCN2 C7orf71 CTD-2653D5.1 RP11-159F24.6RP11-484D2.2 TMEM248 CRBN RP11-97O12.5 QRICH2 MTHFD2L SMCO3 EVPLL POLGLINC00987 AC110926.4 RNF5P1 CCT4 RP1-99E18.2 TAOK1 C19orf47 CTA-384D8.33SACM1L RPL14 RP11-713M15.1 ZFC3H1 IGKV2D-28 PFDN5 PLEKHD1 RBMXP4RPS15AP36 FAF2 S100A11 FABP3 ZNF25 CMC1 ACSL5 CALML6 SLC22A23 AK8RP5-1107A17.3 RBL2 DYNLRB2 GNB2L1 RP11-1399P15.1 DHFR CBARP ULK2 EIF3BRP3-476K8.3 CHPF2 CTB-129P6.7 AC008074.1 CTD-3074O7.5 ULBP1 SSNA1AL022476.2 BCL2L15 RP11-502I4.3 AC093249.1 HCG14 RP5-874C20.8RP11-16L9.2 ERAS ZNHIT3 RN7SL737P RP11-493E3.1 RP11-478C6.2 FAM129BKCTD2 ZNF890P AC104024.2 MCM7 C1orf101 KRT18P57 Z69666.2 OSBPRP11-361M10.3 ZBED3-AS1 IGKV2-28 HLA-DRB1 RP11-182N22.9 HEATR1RP5-1007H16.1 RAB40AL AC004985.12 EIF2B3 DNLZ BRPF3 RPL7P57 GPRC5BRP11-91P24.1 KB-1507C5.3 SUSD2 CATIP-AS1 LINC01184 C9orf173 ALG1L2CTD-2616J11.14 SDHAF4 RP11-1114A5.4 RP11-434P11.1 TM6SF1 GPS2P1RP11-134K13.2 Metazoa_SRP BNIP3P10 RSF1 SRP14 CYTH3 AC012442.6 LINC01399CTA-722E9.1 AC011406.2 LUC7L3 KAT8 AF131215.2 CTD-2574D22.6 ARGFXP2ZNF880 KCNQ5-AS1 FAM177A1 CCDC43 POMZP3 FBXO45 RP11-198M15.1 RPS15AP24LANCL2 NFKBIE FAM167B RP11-613F22.8 KLHDC8A LRFN4 RP11-80H5.2 RPL27ARP11-110I1.5 LNP1 RP11-18C24.8 PHKA1P1 DIEXF TMEM63A RP11-1E4.1 PDCD2CTC-273B12.5 RYR2 CPEB2 EFR3B SETSIP CTB-31O20.3 HIP1R USP41 RPL34P22MAU2 PDCD6IP PNMA3 RP5-1153D9.5 RP11-24N18.1 RP11-92F20.1 EI24 ZNF736RP11-51F16.1 PNPLA8 MTX2 PITX3 RP11-268P4.6 RGAG4 PHBP15 HSF1RP11-118M9.3 AC115115.3 NRBF2P3 KRT8P34 RPS12P26 PPIHP1 PKD2L2RP11-181E10.3 LY6K RP11-395L14.17 CTD-2203K17.1 RP11-707P17.2RP11-749I16.3 IGFBP7 ATP10A RP11-65L3.4 MAP4 RP11-550I24.3 RP11-15B17.4RP11-248G5.9 CXADRP3 AC005757.7 COX20 NDUFC2-KCTD14 RPL23AP74 AC109642.1SLC22A14 RP11-417L19.4 NBEAL1 ZNF575 CTD-2302E22.5 SMARCB1 TRGV4 KNOP1P4AC124944.3 APP MGP RP11-6F2.5 NUDT9 HSPA12A CTD-2373N4.3 TUBGCP3 CALHM3RP11-75A9.3 ADGRE1 SERF2 RBM15 RP11-255B23.1 TAS2R42 RP11-642A1.1 ZNF282RP11-666A8.7 L29074.3 SUPT4H1 ZFHX4 XPOT TUBGCP5 RP11-142I2.1 PYGMALOX12P2 PTGES RP11-80I15.4 FAM92B VN2R17P CUBN CBX3P1 RP11-347C12.10CNN2P4 ABHD11-AS1 DDX53 ASIC4 OCIAD1-AS1 NRADDP RP11-320A16.1 CCDC150NELFB RP11-438J1.1 RP11-7I15.3 CTD-2260A17.3 HMGN1P24 TMC2 LINC00266-3AC006547.15 AL772307.1 GFPT1 RP11-472G21.2 C21orf140 LDHAL6FP PARP8RBM27 NCOA6 GFI1B RP11-401L13.7 ZNF394 U47924.31 AL590762.7 TNNC2 DOT1LPCED1B-AS1 RP11-1084A12.1 ZW10 PARP4 RPL23P2 RP5-1198O20.4 R3HDM4 BAP1PPP1R16B RP11-845C23.3 ABHD1 SCAMP1-AS1 PROC RP4-753M9.1 CTD-2529P6.3RP11-147G7.3 RP11-679C8.2 THTPA AQP6 AC009303.3 ICAM3 OSTCP1RP11-34F13.2 PART1 ELOVL4 NOSIP RIMBP3 LOX AC109631.1 C1GALT1P1 RPL5P9NQO1 TMEM171 RP11-442G21.2 ABL1 ZFP36L2 UBE2L4 SEC1P PPHLN1RP11-754B17.1 RP11-82K18.2 AC079779.4 CDHR5 TRIM71 RP11-720D4.2 TIGD6ZNF414 AC129492.1 PNP SLU7 FGFR1OP AC009274.6 LRRC31 DBIL5P2 API5AF111168.2 CMTM2 YDJC C22orf29 TAF7L CSTF3 WISP3 AC062017.1 OCLNAC064836.3 C11orf31 GPBP1 PCDHGA5 RRAGD RBM23 ADGRV1 TRG-AS1RP1-197B17.5 RP11-1072C15.1 RP11-79D8.2 CAMK2N2 MYOT CTD-2587H19.2 HK2P1CRYAB RPH3AL XKR9 RNF26 FAM163A RP11-159N11.4 IL1B NUP160 CNOT11RP11-96O20.5 FAM83A E2F8 RP11-395I14.2 RP5-973N23.4 IPPK RP11-761I4.5SIGLEC17P RASGRP4 SLC39A5 BX004987.4 FOXN3-AS2 PERP JMJD1C-AS1 KAT5RP4-584D14.7 KIAA1958 ZNF484 CRAMP1 LRP5 GGPS1 RP11-265N6.1 ABT1 RPL35P1LL22NC03-30E12.13 RP11-235C23.5 CTD-2547L24.4 FADS3 OSBPL1A AC007365.1IGLC5 RPS10 DPCR1 CDIPT LINC00942 RP11-276H1.3 LA16c-380H5.1 WBSCR22CYR61 RP1-130H16.18 SLC1A1 PDE12 EIF2S2P3 CATIP HSPD1P6 COL6A4P2UBE2Q1-AS1 ACAT1 PTP4A1 RP11-167N4.2 RPE LTB AC007193.9 AC018755.16ECT2L RP11-329J18.4 EAF1 UNC13D NARF-IT1 UTP20 SSX1 RP11-474G23.3 TBPMYO19 EEF1DP1 TGIF2 RP11-196I18.3 RANBP3L CYP46A1 SLC6A6 KLHL2 GAPDHP22CTD-319515.3 NSUN5P2 FBL RP3-355L5.4 CPEB1 RP11-635N19.2 NCBP2 SLC1A7RP11-757G1.5 RP11-85G20.1 RP11-38L15.2 SERBP1P5 TAS2R6P RLIMP1RP11-609L3.2 PRDX1 FOXO1 HCG4P5 MTCH1 BNIP3P26 VAC14 RP11-514P8.7 SEC22BRP11-397E7.4 RSBN1 UNK GORASP2 CTD-2611O12.6 RSF1-IT1 RP11-77K12.3APOBEC3D SVEP1 DHRS4-AS1 PCDHB19P C10orf10 RP11-195F19.9 RP11-166B2.8ST7-AS1 RPL23AP81 RP11-756P10.6 CDK11A ARHGAP39 GPATCH3 C6orf183CTC-459F4.9 ANKRD20A19P ELP4 H2AFX FCF1P7 DDTP1 ZNF816-ZNF321PRP11-38G5.4 SYCE1 EMD RP11-108L7.15 RP11-480N24.4 RP11-503N18.5 RAD50RP11-109A6.2 RP11-497H16.7 KLC3 MAB21L2 OR6E1P PAICSP4 GOLGA6L4RP11-256P1.1 HIST1H3B RCBTB2 RP11-531A24.7 ERI3 CBR3-AS1 KCND3RP4-673M15.1 CTC-548K16.6 CTB-191K22.6 RP11-378J18.6 RP11-235E17.6RPS20P35 ISM2 C7orf61 EIF6 PGK1P2 RPL17 STAP2 LACC1 RP11-44M6.3RP13-735L24.1 FAM53B-AS1 CTB-58E17.5 UPB1 ZGLP1 TCF3P1 RP11-480I12.9PABPN1 SLC23A1 RPL5P4 RP1-224A6.8 G2E3 GRK6P1 RP11-181K12.1 LINC00240RAB40C CYP20A1 PTGDR2 XRCC4 PTGER3 HMGXB3 GSTM1 RP11-3K16.1 NANP FAM86FPRP11-613C6.2 RP3-404F18.5 HMCN1 RP11-49C9.2 RP11-423C15.3 MARCKS VIM-AS1ANKRD54 ABI1 MRPS23 RP11-256I23.1 FAM171B RP13-15M17.1 TAT HHLA2 PIGHP1RPL21P65 HNRNPA1P14 PWAR5 RP11-190C22.8 NTHL1 CD99 CD99 WDR37 ABCB8 PBX2RP11-1096G20.5 XX-C283C717.1 PCOLCE-AS1 ATP6V1A GS1-257G1.1 CTD-2545M3.2CNP RP11-1250I15.3 RP11-84A14.5 SERINC3 KLF2P2 RP11-550A5.2 FAM192AHLA-L MOB4 TRIB3 BEND3P3 MAPK14 RPL21P40 RP11-76P2.4 LINC00336RP11-154H23.3 OTUD6B RAPGEFL1 S100PBP PCDH11Y SPATA41 SCG3 LSM2 WASH1ACTL8 FEM1C RP11-485G7.6 NACAD B3GAT3 RP11-497H16.5 RP11-705C15.2 PAHAC124997.1 SRPK1 RPL32P29 RP4-614O4.11 CTD-2017C7.2 TTC9 RP11-416N13.1NOP58 ODF2L C6orf201 CHMP4A OR7M1P TAP2 DDX23 RP11-34P13.15 ATXN2TAS2R13 RP11-327F22.1 RP4-669H2.1 PHTF2 UBXN1 RP2 C6orf58 NMRAL1RP11-19G24.1 FAM13A-AS1 RP4-625H18.2 PPP1R1A RP11-138I18.1 HOXD12IMMP1LP2 APIP PAGR1 SUDS3P1 MADD PRMT6 CTB-50L17.9 CCDC6 ZNF675 DUTDENND5B-AS1 RBBP6 DIS3L2 TM9SF1 IGKV2D-29 RP11-75C10.7 CLCF1 PMS2P3CCND3P1 RPS13 RPL7AP2 PRPS1P2 MYLK2 GCNT1P1 RP11-109P14.10 AC006116.19PAK1IP1 AC000089.3 RP11-96D1.9 RP11-182J1.5 KRT8P29 ESCO1 CAPN7 FAM91A3PRP1-102E24.6 STMN1P1 LZTR1 RP11-243M5.3 FLJ12825 RP11-114F3.5 PPP3CAMST1P2 RP11-884K10.7 APOC2 LSM14A ALG1L CTC-508F8.1 CALR3 MTATP6P11PTDSS1 ITGB6 KRT18P55 LINC00548 PABPC4 EEF1DP2 GGA3 PRPS2 SPX AL358852.1CTB-176F20.3 ARF3 SH3BGR C11orf63 PPP1R3G COLQ BTF3P6 RP11-138A9.1RP11-512M8.5 SETD8P1 ZNF134 AC010525.4 LINC01132 RP1-78B3.1 EMBP1 CD24APOBEC2 RN7SL138P RP11-764D10.2 RP3-508I15.14 NOL11 TIMM23 ACADL SNX29P1MSH4 RP11-549J18.1 RPL17P50 RP11-467D18.2 RP11-848G14.2 LINC00680HSD17B11 RP11-485M7.1 FRY WNT3 RP11-16O9.2 RP11-55K13.1 C21orf58 WBP1LP2MBNL1 PQBP1 KRT8P11 UBR7 NDUFB7 EPHA1-AS1 RP11-380M21.1 SEMA3G NSRP1P1RP11-52L5.6 AC010761.9 RPL7P60 AC241377.2 RP11-1074O12.1 AC015849.19HNRNPH1 RP11-352G18.2 RP11-700J17.2 AF131216.1 CTD-2373J6.1 CASP8RP11-1221G12.2 RAD1P1 SDHDP6 RP11-278C7.5 WAC CTD-2526A2.2 ARIH2 EXOC5P1AC018738.2 PPIAP31 RNF14 SMIM7 NICN1 XXyac-YX65C7_A.2 RABIF EIF4G1 DLL4HNRNPA1P16 IDH2 PHB C18orf8 P2RX5-TAX1BP3 ERBB2IP RP4-814D15.1RP11-668G10.2 TSSK5P FLJ27354 RP11-530N7.2 RP11-161H23.10 SRGAP3 ERICH6BRAPGEF3 WDR46 SPDYE21P RP11-796G6.1 LILRA4 CTD-3185P2.1 RHBDL1 USP2-AS1MICALL1 RP11-173C1.1 RP13-476E20.1 EVA1B OTUD4 RP11-57H14.5 BCL2A1RSL1D1 SUZ12 RP11-227D13.2 NVL KYNUP3 GPR179 EEF1A1P3 ST20-MTHFS FAM111BRP1-168L15.5 RP11-333O1.1 ATP5J RNMT COL11A2 ABHD18 AC016907.3 OSBPL2BAG6 RP5-827C21.1 TTC38 CTD-2233K9.1 POLR2J GCNT6 AC006509.4 RSPH4A LY86SNORA7A C21orf62-AS1 AC007952.6 RP1-163M9.8 RP11-744A16.4 LAG3 IQCH-AS1GTF2A2 RP11-133N21.10 TAF1D MARC2 RP1-13D10.2 CTC-453G23.5 PPP2R5D GCOM1AC005614.3 RP11-13N13.6 ZNF430 IMP3 HNRNPA1P68 MLH1 GOLGA8J SERPINH1P1IL17REL RP11-360F5.1 DMXL1 SCN5A NLRP1 CXorf23 KLLN KCNJ10 SP7 PSORS1C2C1D CTD-3096M3.1 CASC10 LZIC PPAN WDR61 MT-ND4L ANKEF1 RP11-521C20.5ARL17A FYCO1 RP11-115H18.1 FABP5 DFNB31 ZKSCAN5 ADNP-AS1 KLHDC9 DNAI1NUDC TRAK1 PPP3R1 ATP6V1G2-DDX39B PSMB6 RP11-374P20.4 CTD-2265O21.3TAF15 SRSF2 RAB42 RP11-1102P22.1 RP11-20I23.5 RP11-649A18.4 MYLPF SRSF8RP11-374M1.11 ATF2 AC195454.1 IL13 RBM28 RNF125 HEATR3 MTRNR2L3 DNAJC7C19orf48 RP11-674I16.2 SNX29P2 RP11-267M23.4 RP11-452I5.2 STEAP3RP11-325E5.1 LPAR6 RP11-91I20.3 KCNK15 XPO4 AP001350.4 RPL18A KARSHMGB1P21 ZNF887P PSMC6 RP11-800A18.3 ZMYM3 FAM157B SEMA3B DDX39B-AS1PIM1 CFAP57 RP13-554M15.2 DHRS13 PDPK1 CES1 CTB-33G10.1 RPL5P30 DNAJC19SLC33A1 RP11-173A6.3 ENPP7 MAP4K4 PEX5 RP11-16E12.2 AL023806.1 KLHL1RP11-661A12.8 CTD-2081C10.7 PSMC4 CD47 AC016722.4 NUBP1 EXOC1RP11-17A1.3 UPK1A CTD-2020K17.4 RASD1 RP11-468E2.4 RANGAP1 VDAC1P11SNORA31 ZBTB48 MCM9 RHOXF1-AS1 GPR152 RPS6P16 RP11-46A10.5 ARMCX7PRP11-85K15.3 DNAJB4 JRK RP11-141C7.3 RP11-563D10.1 CTD-2228K2.2 SOBPNAPG RP11-109D20.2 LINC01556 GMFB SRSF11 NECAB3 RP11-1024P17.1 DNAJC25AP1G2 LINC00960 SPATA32 HIRA ZC3H10 ACOT9 RP11-452G18.2 UBE2D3AP000892.6 GSPT1 CTD-2619J13.5 RP11-323F24.3 TNNI3K RP5-1065J22.8RP11-244H3.1 DUSP11 DRAP1 AC009095.4 RP11-737O24.3 OSBP2 XXbac- PTPN22ASH2LP1 FBXO48 CD79B B562F10.11 NXT2 ARL14 GLIPR1 UBE2CP2 CCDC103KCNIP2-AS1 ZNF398 ZNF280A ABHD17A CHAC2 INPP4B AL133243.4 VWA2 HSD11B1LRNF168 RP11-15E18.1 CTD-3065B20.3 CHD9 LINC00950 DBNDD2 RPS3 CFLAR TBL3ZDHHC5 BRCC3P1 PITRM1 MYEOV2 COA6 API5P1 ADAT1 CTD-2132N18.3RP11-302B13.5 CHN1 MTSS1L UCKL1 RP4-806M20.4 RP11-370A5.2 GAD1GS1-124K5.4 TAF11 RPSAP36 CPLX3 RRM2P2 MS4A1 HIGD1A SLITRK6RP11-212D19.4 PRDX3P1 CTD-3137H5.1 E2F7 CDH23 RP11-327E2.5 TAS2R19 MPDU1KRT18P43 TBX15 SPTY2D1 IPMK RMRP RP4-761J14.8 S100A2 DGCR12 RPL7AP30CACNB1 USP4 RP11-445J14.1 MAK RP11-46H11.3 FDX1L BNIP3P4 CTD-2325P2.3RP11-645C24.4 RIC1 C5AR2 HAMP MRPS24 IGLVI-56 BTG1P1 FO538757.2 AIMP1COPS5 B3GAT2 EMC4 WDR45B IL10RB AC026150.6 SIK1 SAA4 CTC-550B14.6 OSGIN2MRPS11 RP11-598P20.5 EXOSC8 CABIN1 TSNAX-DISC1 PGM5 RP11-326C3.13RP11-195B17.1 RP11-211N8.3 UCKL1-AS1 AC083843.4 RP11-216L13.17 STAT6ROCK1 GNL3 SPDYE12P DFFA TNP2 AC026954.6 VPS26A RP11-66H6.4RP11-775C24.5 SMIM17 VPS4A ZBTB32 TXN AP000436.4 CTB-181H17.1 JCHAINPLEKHH1 RRN3 ABHD14A C5orf47 RAD9A AC068533.7 HSPA4 PPIP5K2 TIMM10 MSH3INF2 DPP9 CYB5D1 POLR2J2 DBF4 FBXL15 TEX30 CCDC189 CALM1 CNBPRP5-1071N3.1 ATF6B RP11-307C12.13 NGLY1 SRCIN1 AOAH RP11-756G20.1 MARCH6RP11-415F23.4 ADIPOR2 KCTD11 RPA2 AC005618.8 RP5-1180D12.1 C2orf82HNRNPRP1 RP11-439E19.9 PIGX ARHGAP1 AC002398.11 RAB5C C7orf25 MCTP1HHIPL2 PPIH ZNF280B SQSTM1 RP11-178L8.8 RP11-77P16.4 RP11-64K7.1 KLHL29CH507-145C22.3 AC002519.8 BAG5 CCDC13-AS1 RP11-252A24.3 TAS2R5 HIAT1AMIGO2 RP11-1379J22.5 SMKR1 VBP1 OLA1P1 GPBAR1 TOMM20L ENO1-IT1 ZIK1SNORA71B SLC25A25-AS1 SLAMF7 GP6 SIK3 TANGO2 TMEM217 SLC25A12 AC144831.3DALRD3 PTPRB ALAD AANAT VSTM4 RP4-681N20.5 RP11-411H5.1 MRPL15 CDCA5CD22 RAB11FIP1 ATF7IP PSMB9 RP11-301L8.2 GTF2H2 RPL7P1 CTD-2349P21.12RP11-665C16.9 THBS1 NKG7 PSMA2 GVQW2 RABGGTB LINC00847 PLAT GIGYF2ATP13A4 DNM1P47 RAB34 SH3PXD2B ANKFY1 CMTR2 AC026202.3 CYP2D6 DPRXP3ARHGAP35 NFXL1 ATM MUT PYCR1 PDE6C RSPH10B RP1-224A6.3 NOL4L FKBP14TCEB3 MAD2L2 CCDC115 RP11-195C7.3 ASS1P1 IREB2 C15orf57 FABP6 ULBP3MAP4K5 MRPS16P3 RP11-248C1.3 RP5-854E16.2 NAA30 CTC-265F19.2 ZC3H11BP2RY10 NPFF RP11-1008C21.2 VN1R42P TACC1 HCK LA16c-313F4.1 RP11-362K14.5CLCC1 RAB35 CCNL1 CICP4 TP53TG1_2 NSDHL RP11-68E19.1 CTD-2555K7.2CH17-264B6.4 PFKL CTD-2249K22.1 MANBAL WDR81 LINC00969 CTD-2013N17.6DPF3 CTSD RP3-402G11.26 FGFR1OP2 FBXW12 HFM1 BMS1P2 PFN1P6 RP11-864J10.4CSE1L ZNF222 ARSK SMIM18 SMYD3 LA16c-360H6.3 HMGN1P8 TRIM60P18 HOXA-AS2SMC5 NCOA3 SIKE1 SYNJ2BP CTAGE9 NAA20 TTC19 TNK2 DPY19L2P2 RP11-383C5.3TRIM13 FH BANF1 IQCK TMEM255B IGLV3-21 NPAS1 PIP4K2B NT5M HYAL2RP11-27I1.6 RBM25 RP11-247I13.11 PPME1 RP11-473O4.5 RP11-804A23.4 LANCL3CENPM CTD-2302E22.6 CTD-2196E14.5 PLRG1 WDR77 UQCRC1 NDUFB2 RAB22A KIF9AC005077.14 PPAN-P2RY11 ZNF771 ASUN DDX3P1 NOP9 RP11-640N20.6 GATC MC4RC6orf47 TIMM8A C1orf27 CTD-2522E6.4 TRIM52 KTI12 RBM5 BRD8 BOP1 RNF114IGHV7-81 AC007292.6 FAN1 C11orf54 THA1P SKIDA1 DCUN1D2-AS BOK-AS1MED28P3 LBR PGS1 RP11-452L6.7 SSBP1 HSP90B2P PRR5L SURF6 ELFN2 PTPN14RP11-126O1.5 PTGR1 ARHGEF37 POTEF HACD3 RP11-160E2.6 RP5-1061H20.4 PSD2MCF2L-AS1 RP11-143I21.1 UNC79 RP11-111M22.3 NR1I2 MB GART PTPN11CTC-378H22.2 NKRF RNFT1P3 GAS6-AS1 RP11-210N13.1 RP11-346D14.1 CENPURP4-616B8.5 AVIL RP13-753N3.3 ZBTB43 MIF4GD CTD-2014D20.1 SLC25A32RP11-20I23.6 HMGA1 CTCFL PAQR4 IGHV3-33 RP11-231L11.3 RP11-214F16.8NSRP1 EGR3 NEK11 CTB-131B5.2 ZWILCH ISY1 RP11-686O6.1 ADAMTS4RP11-423P10.2 RP5-1112D6.4 CCBL2 LAMC3 CHORDC1 DECR2 SH2D3A CPTPAP003385.2 SGMS1 HECTD1 PPP2R1B CCDC114 TFAP2A AP000580.1 USP44 TTC1CTD-202417.13 RP11-609N14.4 PIK3CB RP11-151N17.1 AVPI1 RP11-445L13_B.3WDR12 AC145110.1 MMP24 SLC2A5 LINC01137 RP11-573D15.8 CHAC1 UBP1 ATP5BRP11-171I2.4 S1PR1 APAF1 METTL2B C14orf178 CALM2P3 NGDN MIR1539AC005306.3 TRMT11 TMEM186 WDR87 WDR83OS Metazoa_SRP ALDH1A1 C8GRP11-624A21.1 ZBTB26 STRC RP11-354E23.5 RAB15 GSTA1 LINC00998 ZNF101EIF4EBP1 RP11-486I11.2 SLC30A4 PSMD5-AS1 RP11-996F15.2 GEMIN8 USP16MICU2 SRCAP CHRNA9 PCF11 YLPM1 RFX7 LRRC8D INO80B RP11-745O10.4 WDYHV1ADCK2 LCN12 RP11-225N10.1 RPL9P9 SNORA74A TBR1 RP11-348H3.2 RFC1 MGARPSNIP1 WASH7P LINC00945 EFCC1 FTH1P12 SCARNA13 RP11-815I9.4 MMP24-AS1APOBEC3C EIF5 MED4 VIPR1 CLDND2 GFRA2 RP11-165F24.3 NHSL1 TLK1AC136352.6 LINC00493 CTC-559E9.1 LINC00176 IPO13 TFPT BNIP3P37 ZNF235IGHV4-31 NPIPB4 OTUB1 AC003075.4 SMG1 FAM217B C10orf131 PLEKHA4 HAUS1GRK5 MIS18BP1 C5 PCGF3 RP11-43F13.1 POT1-AS1 CNIH2 RFX1 DDAH1 ERCC6LAC005740.6 FGF9 RP11-325K4.3 LAD1 CD27-AS1 TUBA4A TMEM219 GS1-259H13.2CYCSP10 ATP10D BBS7 RP11-314N13.3 ZNF668 MESDC2 NACA3P RP11-333E1.2RP11-255E6.5 RAI1-AS1 CTD-2555O16.1 FAM136A AFAP1L1 CTD-2666L21.2 FBXO3ZC3H6 ARCN1 PA2G4P2 C2CD2L ERN2 RP11-458J1.1 CH507-24F1.1 RP11-179B2.2NIFK BLOC1S6 ACSM3 P4HB KIF27 ATP6V1C1 SEC61B RP11-440I14.3 AC068134.10RP11-10C24.1 RP11-154H23.4 C4orf48 MRPL4 SVIP CDK5RAP3 RP11-803B1.8RP11-511B23.1 TMEM245 ACBD4 NDUFS3 RP11-178L8.7 CDK12 YARS2 AP000487.5ZNF426 FAT2 MED13 MT-CYB AP001059.6 UBE3C RP11-96H19.1 DDX49 ZFYVE28IL27RA CORIN PCDHB18P DCK A1BG FTSJ3 MTERF3 SLC15A4 PAX6 RP11-680G24.4RP11-301G19.1 RP11-749H17.1 ACTR8 RIMS4 UQCR10 SNX3 STT3B ZNF592 CARSTAF1L RP4-592A1.2 TIMM10B ATP5J2 ZCCHC8 AHSG RP11-799D4.4 AK4P1 KIF1BDNAH7 RP11-100G15.3 C12orf43 LSM6 TRIP11 COPS8 PMS2CL TAF2 RP1-228P16.1ZC3HAV1 PRG4 DCAF4 RP11-36I17.2 PTP4A2 RIC8A GXYLT1P5 TCP10L SF3B3 NRIP2CTC-479C5.12 RP11-1212A22.4 RP11-583F2.1 WNK4 SAMD1 KRT7 SNU13 RPS3AMDC1 C16orf46 NSUN3 RP11-568J23.2 CNIH1 MTCO1P30 ZNF614 APLP1 MTL5 COG8RP11-296E7.1 CCPG1 COG7 TOMM6 RP11-16L9.1 GIGYF1 RP11-420A6.2 NEU3 HEBP1C12orf49 RPS4XP1 TUSC2 RP11-319G6.1 UTRN AP001046.6 SLC25A20 FAM87B VHLLTMEM81 ATF7IP2 MPI IQGAP1 TGFB1I1 PTGES3P4 AP001042.1 POLR2CPGLTSCR2-AS1 ALG1L9P RP11-561C5.4 SRGAP2C RP11-571L19.8 GPR180 MYL12BP2AC098820.4 RP11-539L10.3 MST1 RP11-1148L6.9 PDF ADPGK ULK4 CEP57 SELTACAP2 FSD2 RP11-89C3.4 LINC01426 BNIP3 FDXACB1 LINC00662 CTD-2267D19.1TGM1 AC006042.8 PSMA2P1 RTCB C9orf114 RP11-456P18.2 BCL7B GUF1 CCDC153ARPIN SDR39U1 RP11-448A19.1 LL22NC03-63E9.3 RP11-15K19.2 TMSB4Y LETM2CTA-228A9.4 DQX1 ZNF658B ARPC1A ANKRD18DP UBE2J1 SNAPC3 IGKV5-2 ESAMCARNS1 FAM199X OLFML3 RP11-359B12.2 SERHL DLK2 HOXA11 SMARCAL1 XKR8LGALS4 NOXA1 RP11-338K13.1 UPF3AP3 BRE ATP6V1G3 MFN1 PINK1 ARHGAP9CTD-2206N4.4 GPR160 COQ10A RTFDC1 RP11-466J24.1 RP11-106D4.2RP11-20D14.6 DNAJC10 RP11-158H5.2 CFAP97 PEX13 RP5-1021I20.6 MYLK TPI1P1DNAJC1 MRPL54 BTN3A1 TMEM220 RP11-120M18.2 NPC2 RP4-561L24.3 KLHDC10SNHG19 ASB1 RPS4XP2 PFDN6 RPL24 RP1-111B22.3 RAB1A OIP5 GRM1 SERGEFFASTKD3 ZSCAN5A MRRF CHCHD3P3 LINC01422 DPY30 LYRM9 ATP5I FUNDC1 ATG7SRRM5 COL25A1 PSMB5 PSMB2 RP11-434D12.1 EEF1A2 RP5-1120P11.3 LINC00309LINC01189 USP9X MYC RP11-791G16.4 NFIB RP11-12M9.4 CHM NOB1 RPSAP19PANK2 FAM126A RP11-271K11.1 RP11-20G13.4 SND1 NOL6 RP3-467N11.2 PHF10RP1-281H8.3 HSPA12B RN7SL49P RABL2A OCIAD1 RP11-15A1.4 KDM4A-AS1 LIN7APTPRCAP MICALL2 MTMR14 BPHL RP11-145M9.5 LUC7L2 AC000123.2 PPATP1NFATC2IP MFGE8 PROZ RP11-795F19.1 ZGRF1 RCOR1 LIMK2 MPHOSPH6 MTND1P11FTH1P2 GOLGA4 WNT6 DDX21 CTC-559E9.13 UBFD1 SLC2A4 AL136097.1 KNG1TMEM180 RP5-1157M23.2 CLK1 RP11-981P6.1 COQ9 POLQ CARD8-AS1 NUFIP2SNAPC5 LL22NC03-80A10.11 EPAS1 ENO3 ZNF564 RP11-1148O4.1 LONRF1RP11-111K18.2 RP5-1159O4.2 CTD-2331H12.7 RSL24D1 RP11-214K3.24RP11-20B24.7 UBL7 RP11-598P20.3 SUMO2P19 RP11-640N20.9 INAFM1 WFIKKN1FXYD7 DAAM1 TMEM167A ACYP1 GNS ZNF420 RBM26 CTD-2293H3.2 RP1-267D11.6NHLRC1 SLC9C1 CTC-542B22.2 RP11-76C10.6 RP1-224A6.9 SEC13 AC074183.3RP11-498C9.13 MLLT10P1 TRRAP F12 RP3-400B16.1 RGS9BP RTF1 PTPRVP FAM134CRP11-475I24.8 YES1P1 PCDHGA2 DYRK1A LONP1 RP11-723J4.3 ZNF81 FTH1P10TEFM CTD-2049O4.1 RP11-1C8.6 TNIP2 KRR1 ABI3 CTC-297N7.1 RNF13 STRAPAP3M1 ATP6AP1L RP11-701H16.4 PTPMT1 RP5-991G20.2 RP11-887P2.6 LAMTOR3LINC01602 C7orf43 ALDH8A1 MITD1 SRR USP3 CDK11B HLA-H PRMT3 ZNF664 ICE2RP11-431M7.3 TSSC1 TEKT2 RP11-231E19.1 MAD2L1 RP11-946P6.6 TNFAIP8 CAPN2LSM7 T RP11-17E13.2 PALM2 CSK SPG7 RP11-152F13.8 HAO1 CYCS TBC1D3LPPP2R2A SKA3 LLNLR-246C6.1 RP11-379K17.9 ZFHX2 RP11-432B6.3 BLMHCTC-215O4.4 C21orf91 DCTN5 LINS1 UBIAD1 GOSR1 SRP72P2 RP1-69M21.2SLC39A12 RGP1 FAM186A TMTC3 LA16c-313D11.12 DNTTIP1 GPCPD1 DCP2CTB-50L17.14 VPREB1 AC002398.9 NAV3 APOO RP11-806L2.2 APH1B PRPF38BRP11-895M11.2 CTD-2145A24.5 AC074367.1 NOL10 SEC61A1 ZMIZ1 RN7SL81PCXCR3 RP11-1293J14.1 AC016910.1 IDH3B ANKLE2 AC005104.3 CTD-2349P21.1DCDC1 ISCU CYP2D8P SLC5A6 PCMT1 RP11-318E3.9 RP5-1112D6.8 RP11-61N20.3DCTN4 LINC01260 RP5-867C24.4 ZCCHC10 RP11-79P5.9 RP11-45A12.1 MTBPTSPAN4 AGR3 FBXL18 RP11-649E7.5 RP11-151A6.6 CD28 SEPT7P6 TSSK3 SEMA4BSIRT2 TRMT10A RPL7A LATS1 RANGRF FRG1HP RP11-180O5.2 TNFRSF14 RBBP5NDUFA7 UFSP1 AC093162.5 CPT1B RP11-325P15.2 KBTBD7 RP4-616B8.4 KIAA1549SRSF10 NOA1 YWHAE CTD-2152M20.2 GDI2 XXbac- ATP5G1P4 B476C20.13 PLGLB2RP11-486F17.1 ST5 MED10 RP11-214J9.1 CTD-2044J15.1 MFAP5 BOKRP11-569G9.7 RAD21-AS1 LRRC27 CCDC130 OGFRL1 AC006942.4 EXOSC2RP11-379F4.9 SLC35B3 FLJ38576 NACA FASTKD2 IGKV1D-13 FGL2 DYNLT3 RECQL4SUGP2 RLIM SENP5 RAB24 RP11-414J4.2 PIH1D1 RP11-385D13.1 VDAC1P9RP11-194N12.2 SEPHS2 RP11-342K6.4 BAZ1A LINC01534 VDAC3 EIF4ERP11-700A24.1 NUP54 ICOSLG RP11-46C24.7 RP13-516M14.10 RP11-559M23.1NECAP1 ZNF100 RP11-65D17.1 PCDHGA7 PLAC8 TSEN34 RP11-137H2.4 GPR143GTF2E1 RP11-266L9.5 OXCT2 NME3 AC022154.7 ORC2 CDC45 LRRC8B DHRS3RP11-39K24.4 FAM188A ARVCF SBF1 UHRF1BP1 RICTOR IGHE LINC01473 FAM214AITFG2 GBP1 TRMT10C AL133245.2 KREMEN1 FAM89B CNKSR1 RP11-245J9.5 MTRF1LNIM1K FAM102A AEN C2CD4C LINC00167 MEMO1 LINC01185 COQ3 PSME1 GCLMPROSER2 CD44 RUFY3 POLE CDCA4 RP13-131K19.1 CTA-989H11.1 KLHL36 TMEM75CMIP FKBP3 SLC39A2 RRP9 PLPP2 SLC16A6 RPL3P7 RP11-264J4.8 CCDC54HNRNPA1P70 MIS18A-AS1 AC008993.2 SPTBN5 ZNF732 RPAIN POU5F1P3 CICP23HERPUD2 PRKDC RP11-164J13.1 USP10 FOXJ2 TMEM45A AC004549.6 RP11-543B16.2ACTG1P14 RHBDD3 FANCF TRAPPC2 NAPSA FAM8A1 PPFIA4 ISCA1 RP3-337H4.6HMG20B RP4-801G22.3 GPBP1L1 PRKACA RP11-295P9.13 RP11-250B2.4 LINC01619HIST1H1E RBM48 RPL6 RP11-363N22.3 MYSM1 RP11-421E14.2 ARF4 DTD2 PTPRATMED5 Metazoa_SRP RAPSN RP11-173A16.1 FARSA RP11-168O16.1 RN7SL559PST3GAL1 SF3A3P1 TAPBP VAPB GALNT4 ZNF713 CYP51A1P1 GTF2H5 OR2AG2RP11-284M14.1 RP11-102M11.2 GPS1 RP11-46H11.11 VAV2 MPPE1 BRAP RPS7RP11-449G16.1 PVRL1 ZNF681 KIAA1109 RP5-902P8.12 CENPH RP11-410L14.2BAK1 SMAD9 RP11-227G15.3 ERICH6-AS1 SORBS2 RPL27 RP11-181D18.4 CANX SDHBIGLV11-55 FAM208A ZNF746 CTD-2649C14.3 RPL7AP65 RP11-739N20.2 FLVCR1-AS1RP11-519C12.1 GFI1 RP5-1165K10.2 RPS20P4 MOCOS MRPS31P4 ANKMY1 MAF1DHRS7 RSPH6A ZBTB9 DTHD1 CA13 RP11-295D4.4 HEMGN COPS6 GLRX2 MTMR8RP11-473M20.5 NDUFV2 FAM217A NLRP14 WDR7 RP6-159A1.2 CTC-366B18.2 USP24TXNDC12 HAUS6 RP11-454F8.4 LINC00528 MRPL40P1 ALKBH5 PDHA1 ATL2 THOP1SNX1 BACE1 IBA57 AFG3L1P ASXL2 ADPGK-AS1 RP4-584D14.5 RP11-390K5.6 NBNTMEM251 RP11-421L21.3 RP11-597A11.4 RPUSD2 PIGS TMEM150B ZNF558 SAPCD2POM121L1P ZNF396 RIN2 ZFPM2-AS1 NDUFV2P1 ZNF146 ASAP2 CTD-3154N5.2 ODC1CTA-363E6.8 MXD4 EPB41 ASF1B SLC2A3P4 RP11-755F10.1 RNF126 ALDH2 SUPT7LRP11-69J7.1 RP11-386J22.3 RP11-411B10.7 SERPINE1 RN7SL834P BTN3A2RP4-564F22.5 BNIP3P24 CTC-325H20.7 LRP2BP PRKAR2A-AS1 FAM3C NCAPD3RP11-728K20.3 TTLL5 NEO1 LENG8 SSR3 CDK5R2 RP11-762H8.2 PRKRIRRP11-107E5.3 MTR GCFC2 AC007292.3 TREML2 RP5-1021I20.4 UBE4A CORO1CHENMT1 RP3-449O17.1 TOMM5 RP11-290F5.2 MED7 IFT20 CCDC82 BTF3RP11-30K9.5 PIAS2 PIF1 AC145124.2 UBXN11 RP11-140L24.4 NR2E3 C5orf45RP11-347C12.11 ABCD1 CYSRT1 RP5-1021120.1 RP11-537H15.3 PMS2P6RP11-120E11.2 DRICH1 LA16c-60D12.1 RP6-218J18.2 WASF4P RP11-307L14.1GPR150 GJC1 RP4-647C14.2 AL590762.11 RP11-727A23.7 CTD-2210P15.3 RNVU1-7GNPTAB CH507-9B2.9 AP000692.9 YAF2 NOP56P3 ERGIC2 VCPKMT RP11-98J23.1UBOX5-AS1 STXBP2 RP11-488L18.4 RP11-736N17.11 MTND4P12 RP11-169K16.8RP11-345J4.5 C7orf57 NFIC SEPT14P19 RPS28 RP11-142L4.3 ATP6AP2 PAXBP1SCARNA10 ATP6V0E1 RASL11A OSTF1 LUC7L UBE2L6 ACAT2 FN1 HIVEP3 HSPA1LRP11-103B5.4 RP13-514E23.1 TMBIM4 DDX58 DHRS4L2 CDR2 TAF1B NCR3LG1C17orf47 RP11-295G24.5 CNDP2 PHKA2 LSM1 ESRRA AHNAK2 GOLGA8S RNF219-AS1WNT2B SMG1P3 RP11-837J7.3 RP5-1112D6.7 RP11-667K14.5 RPL21P122RP11-676J12.9 BSPRY HOTTIP SPDYA COPE FAM186B LINC01484 BTF3L4P2 BLOC1S3RP11-44F14.6 AC005785.5 ADAM29 RP11-536C5.7 SMYD4 LLNLR-222A1.1 COX7A2LRP5-890E16.5 AHCTF1 DSN1 ERO1B RP11-477N3.1 RP11-426D19.1 NUP35RP11-681H18.2 RP11-539G18.3 PHF5A RP11-331F9.4 RP11-210K20.5 IMMT ALDOAFRG1 PAOX THOC1 RP11-705C15.4 RP11-1020A11.1 CTB-50L17.5 AC010132.11DNAJB11 GNAO1 RPL11 RP11-161H23.5 TF RP11-385F7.1 HDAC1 RP11-15E1.5 PPIECTD-2301A4.3 RP11-667K14.3 RP11-165D7.5 TMEM145 TM4SF20 BUD31CTD-2083E4.4 HLA-K CRLS1 LINC01506 RPS2P32 RP11-416N2.4 RP11-570P14.1CTD-2248H3.1 GORASP1 ACOXL GAPDHP52 ELMOD2 RCOR3 RP11-242J7.1 C11orf98DOK4 AURKB RP11-475I24.3 CYB5RL TMEM14C DUS2 RP11-110I1.11 RP11-803P9.1PCNPP1 HDHD2 SMYD5 MIR194-2HG ZNF70 ZNF618 HES1 CEP131 AC007038.7 ARF1CCL5 CTD-2561B21.8 CHURC1-FNTB LA16c-358B7.4 RP11-707O23.1 CALU PIBF1AP000255.6 RP11-474D14.2 RP11-297D21.4 PHACTR4 RP11-982M15.8 THAP5 TLR6RERE RP11-1046B16.3 DET1 SLC44A4 RP11-316M21.7 VCPIP1 ZRANB2-AS2 ECSITDDR1 KLF2 RBM43 SZRD1 CMAS PMCH DIXDC1 CRYBB2P1 HLA-DOB PRPF4 RP1-30M3.5CTC-366B18.4 RP5-908M14.9 RP11-212P7.3 RP11-424M24.3 RP3-425C14.5AC007389.1 VPS26B NAF1 URI1 CTC-260E6.4 FNDC8 RP11-493G17.4 PRKRIP1CTD-2616J11.3 SLC39A7 SNHG21 DPY19L3 ACTG1P17 MON2 RAPGEF6 EIF2B2RPL12P9 GOLGA5 BMS1P10 RALY-AS1 RP11-334J6.6 CTD-2510F5.6 NDOR1 METTL3GS1-293C5.1 FANCE SUSD1 HIST1H4E IGLV3-9 PHBP2 EIF3F CRHBP HM13 SNX5P1RP11-455F5.5 BFAR OASL RP11-463I20.1 RP11-159D12.8 CASP4 ESYT1 DLEU1DCHS1 EDRF1-AS1 B4GALT6 LRRC58 ZDHHC11 RPL30P11 RP11-484D2.3 HGSNATALOX15 TNPO1 KIAA0196-AS1 AC024937.4 DDX56 RP1-317E23.3 GLG1 FUBP3CTD-2313J17.5 PLCH1 TRMT13 KLRD1 ZNF689 ATP5L DHDDS RPL17-C18orf32RP11-424C20.2 ZRANB2 SS18L1 AC090505.6 ZNF33A RP11-467L13.7 NHLRC2RP11-139H15.6 NUTM2F VNN2 A2M ZNF696 TRAPPC5 RP11-662B19.2 RP11-410E4.1RPL7AP11 RP11-676M6.1 FAM21C SYT1 LMO2 RP1-313I6.12 ODF2-AS1 INTS6P1FAM96AP2 CENPB CDC123 HDHD3 DNAH12 EVPL PPIAP29 ADSS CREB1 GMPR2CTD-2013N24.2 GPR135 PROSER1 OR1F1 RPS16P9 ZHX3 RP11-45A17.4RP11-108K14.8 RPL18P10 HIST1H3E C12orf73 INO80E BRD2-IT1 TCAIMRP11-57A19.5 LINC01268 MRPL34 NOC4L GTF2F2 RP11-203H19.2 FNTAAC073063.10 STX5 MRGBP METTL23 RPS3AP25 CMTR1 IRF9 SHQ1 TMEM62DDX26B-AS1 SASS6 PPARGC1B RAP1A GTF3A CYB5R1 RP11-58A11.2 PWWP2ACTD-2017D11.1 RAP1GAP RP4-635A23.4 PCDHGC4 KCNC4 TUBB8P8 ZNF213-AS1DENND2D DOCK9 RP11-147L13.12 PAN3 CTD-2184C24.2 EXTL1 RP11-87E22.2 TMEM9RHBDD2 RP11-63K6.1 RP11-264E20.2 ARHGEF1 YY1 SUGT1P2 GTF2H3 RP11-817I4.2SLC30A5 APEH MIPEPP3 TRIM74 RP4-613B23.5 RP11-894P9.1 BNIP1 CPED1 ARFIP2CORO7-PAM16 GPI NOL3 ABHD14B RP11-545E17.3 TEX261 IKZF2 COMMD5 RN7SL75PTMEM126B RP4-616B8.6 MPP5 RP11-503P10.1 PCDHGB8P HLA-DMA ATP2A1 DCUN1D5SOCS7 PSMB1 PPP6R3 CTA-268H5.12 ITGB3BP RP11-775C24.3 HIST1H4D TMEM189SEMA6C TMEM88 MPHOSPH9 SYAP1 FBXO41 CTD-2036P10.6 IQSEC1 XPOTP1RP11-23P13.6 C4orf47 RP11-731F5.1 RAB6A C1orf131 BIRC6 CTC-251D13.1INAFM2 CTD-2396E7.10 AC005253.2 NOL7 SEPT7P7 ATP6V0B CHRNB1 TMEM200BEXOC3 HCN3 ZDHHC3 HAUS7 PLIN5 LRGUK SUSD6 NEMP1 USP45 RP3-455J7.3 ETFARP11-158L12.4 COA7 TIMP1 KLRC4 PTOV1-AS1 DSTNP1 SMCR8 ACTG1P10RP11-572B2.1 CTD-2002H8.2 ZNF763 CHPT1 RP11-407G23.7 RP11-268J15.5RP5-994D16.3 RP11-136K14.3 LA16c-325D7.2 RAB30-AS1 MAP3K2 ECE2CH17-80A12.1 RP1-117O3.2 USP43 RP11-54C4.3 VTI1A WASH2P NCAPG2 HSPA6SVBP CHI3L2 RP11-229D13.3 AC106875.1 CBWD2 CTD-2086O20.1 RBBP4P2 MRPL41NEK4 DOC2GP SEMA7A NAPA-AS1 SFT2D1 RP11-142E9.1 SF3A2 DTX3L AC010761.13GS1-124K5.3 TMEM126A ACTA2-AS1 CLIC1 FLJ37O35 PANK4 RP11-172F4.2 ERCC6ORC4 LYAR EIF2S2 CIAO1 MYO18A AC097721.2 CTD-2369P2.12 CCL4 C7orf55B4GALT4 AFTPH ACTR3C NTAN1P2 RP11-706O15.3 RP11-83A24.1 DBR1 ADAMTS13AK3 VPS4B SDAD1P1 TMEM205 PDHB ZXDC RP11-461A8.1 TOMM34 SNHG4 C4B-AS1C4A-AS1 EPM2AIP1 NUPL2 GGA1 ACAA2 CDK17 ZNF433 CTD-2561B21.3 MRPL57WNT8B ATG3 YBX1P1 AUH UBE2SP2 INTS5 PGD ST13P15 BRWD1 POLD3 GNPNAT1PP7080 DERL2 NHLRC4 HINT3 KB-1410C5.5 RPL7P22 MGAT2 ZMYM6NB RP11-849F2.9HCG4B RMND1 UBE2B ANXA9 RP11-977B10.2 CH507-513H4.1 CH507-528H12.1GRAMD1B TRIM68 TMEM179B RP3-425C14.4 RP11-417L19.5 AUP1 ADAT2RP11-417N10.4 C15orf62 RP11-855A2.2 LINC01125 RP11-1000B6.7 FAM124AARMCX5-GPRASP2 GALNT3 STX18 NMD3 C19orf25 RP11-28G8.1 TSPAN12 IGHV4-61C9orf78 ZNF775 TPD52 KIAA2026 PRKAR2B SARAF HAUS6P3 PIGP NPM1 MT-ATP6CTC-260F20.3 GALNT11 CDC37L1 RP11-460N11.2 RP11-270C12.3 RP11-500G22.5NOL9 WDR19 ADGRL4 RP11-203B7.2 PHLDB1 PFKFB1 CCDC136 BCAT2 RP3-402G11.27RP11-343L5.2 PPIL4 MNS1 TBC1D31 CENPC RFXANK DGCR6 RP1-197B17.4 CHMP5NUBP2 CTU2 ANKLE1 HERC2P2 POM121L9P BAG4 TRDV3 TTC33 SLC2A1 ZNF597TMEM222 SLC41A2 RP11-234B24.6 TMEM38B BTBD18 TBC1D3I KLHL12 POLG2 MT-ND6LAMB1 RP11-702F3.3 FDX1P1 USP36 RP11-526I2.1 Sep-08 AP5Z1 MRPL42 POLKMRPL35 RP11-253M7.1 SETD8 THAP1 OPA1 RAB1B AC034243.1 RP5-1009E24.8IMMP2L SBDSP1 RP3-325F22.5 PHOSPHO1 SCOC-AS1 DNAJC8 OVCA2 RP11-474P2.7B4GALT1-AS1 IL17C EIF3LP2 AKR7A2P1 MT-ND2 RP1-39G22.4 XXbac- IL15 ZNF674BPG249D20.9 NUP58 STK24 METRN MASTL RPL31P49 RP11-382A20.1 RP13-554M15.7SERBP1 C2orf88 ZNF138 TRAPPC10 TUBAP2 DNPH1 C3orf58 RNF11 RP11-932O9.9FBXO24 HTR2B RP11-521C22.2 DCLRE1C TRMT10B DSP VN1R108P RP11-20I23.1PEG13 TEKT5 CH507-154B10.2 RP11-574E24.3 PQLC1 GOLGA8K SYS1 RN7SL431PCTD-2020K17.3 NAP1L4P1 RIF1 MTRF1LP1 SRXN1 RP11-333E1.1 PROCA1RP11-567G24.1 SYCE2 TECPR1 CENPO RP11-135N5.3 AP001469.9 DUX4L50 MRPL39TREX1 TMEM164 RPRD1B RP11-837J7.4 COG2 PRR26 PSMG3 DTX2P1 DOCK7RP11-456J20.1 TUBG1 ABCC5-AS1 OTUD3 EED RAD51D PREB RP11-513I15.6PRR23D2 ERP44 MAPKAPK3 RPS10L EXOSC7 CTA-390C10.9 TMPRSS9 RP11-303E16.2NOTCH4 PCID2 SLC9A3R2 DNAJC3 NDUFB4 MXI1 SUN2 MPHOSPH8 LINC01160 DPP7EEF1A1P13 DPH5 PIGZ CTD-2095E4.3 TMEM63B POGLUT1 MCCC1 RP11-42O15.3HSPA9 RP11-127B20.3 LRRC57 MYOM1 NLRP6 SPCS1 ERGIC1 SCRIB AXIN1 PNO1FGF22 CTD-237614.1 PSME3 RP11-493E12.2 MPLKIP ADGRF5P1 RHOA ZNF264ABHD17C MRPL49 POLR2F MAGEA2 ATP6V1D CLDN23 TRMT5 TOR1A CIAPIN1 SLC25A51POTEE IRAK2 RSPRY1 RPL29 MRPS33 RP11-356J5.13 SH3GLB2 REST AC005523.2MPZL2 SPTY2D1-AS1 HMGB3P24 OAS2 ZFHX3 PPA1 GEMIN6 LL0XNC01-116E7.5RP11-477D19.2 FIS1 PRKAR2A RP11-288I21.1 EEF1A1P14 TGDS FMR1 TRIM69DENND4C MMS22L P2RX5 WDR18 TMED4 RP11-74J13.9 AP000487.6 RP11-690I21.2NPHP3 RNPEPL1 ACTR2 RP11-554J4.1 PPM1A FRAT1 DHRS7B RP11-355O1.11RP11-465B22.3 CTC-523E23.3 RP11-50D9.1 NDUFB9 TMLHE DNAAF5 MVB12A POC1BAC010883.5 HSPA2 TMCO6 RP11-932O9.8 C17orf75 APCDD1L-AS1 FOXN3-AS1 KMT2DDCAF13P1 CTD-3092A11.2 RUNX3 MED14OS C5orf51 RP3-412A9.16 IGKV2-30ZNF215 RP11-667M19.2 PCNP EMC9 REXO1 CCDC25 ZNF395 NEK3 C1QBP FAM185BPCPLX1 LA16c-390H2.4 BAIAP2-AS1 MACC1 GS1-124K5.12 RP11-713N11.6 RPL7P32AC010504.2 FBXO47 IRAK4 ERAL1 VPS37A PRR23D1 ECHS1 LINC00674 PRDX5RANBP10 HECTD4 AKAP11 AP001619.2 XPO6 SLC25A37 RP11-1000B6.8 AC137932.5MYCBP2-AS1 LINC00886 MRE11A CHERP SETD1B PMS1 RP11-259N19.1 ZFP91-CNTFPML TLE3 PTPRH PIGT INTS4P2 RP11-379K17.12 RP11-295P9.3 RP11-274B18.4RP4-816N1.6 SLC11A2 RP11-16P6.1 RP11-25K19.1 NUP37 ZNF66 RP11-401N16.2DISC1FP1 ZNF445 RP11-120D5.1 OPA3 PHKA2-AS1 ATP5C1 RP11-408A13.4RP11-30K9.6 C6orf106 NNT-AS1 EEF2KMT WDR59 EIF2S2P4 VPS37B PPP1CA GFERRPS27L RP11-700P18.1 AKAP17BP RNF216P1 MGA TSR3 RP11-567I13.1 ADCY3 GLI1TBCE RP11-734K2.4 RP11-19P22.8 RP11-63A1.1 MT-ND3 GUSBP1 NAALAD2CTD-3088G3.4 SPG11 KCNQ5 HAT1 USE1 RNGTT ESF1 STOML2 C6orf3 MMADHCRPS20P33 CUL4A TMEM52 FTL KCNJ14 RP11-298I3.6 CTC-756D1.1 SMN2 CNTFUSP20 TSG101 RP11-128N14.4 SEC62 RRN3P2 EPB42 RRP15 BTK GPR75 ZNF747AVL9 LA16c-380F5.3 COQ10B RRS1 BCAS2 GOLPH3 HSPD1 RP11-468E2.10 PPT1MTND1P23 CA5BP1 POTEC MRPS17 CTC-260E6.3 RP11-666A8.12 SNX19RP11-378J18.9 RP11-867G23.8 CTC-398G3.1 ERN1 SGIP1 ANAPC13 TMEM147AC092580.1 OR13A1 DCAF17 RP1-266L20.2 SPDYE1 HNRNPA3P10 AC113189.5AL928768.3 ZDHHC6 TMEM104 GRPEL1 ANP32BP1 HOXA4 RP11-192H23.8 PTGER4RP11-326C3.11 ADD1 LINC01315 RP11-435O5.5 CCNT1 ZNF500 ABCF1RP11-266L9.4 NDUFA6 GINS1 AASDHPPT TSR1 MKRN3 FAAP100 SLC38A10 SLC26A6RGS17P1 RNF123 RP11-72I8.1 UBE2R2-AS1 ZSCAN30 DFFB AOC3 ATP1B3-AS1EFCAB14 AC022182.2 HMG20A CEP152 INO80D AGFG2 GEMIN8P4 WASH3P PNPOTBC1D1 TIMM9 NUS1P1 RPL7AP66 B3GNT4 FTSJ1 PASK CDK5 HAL FYB HMGN3-AS1AGAP6 RP11-247I13.3 SRM RP11-599B13.3 SAP30BP AF230666.2 ACTG1P24 ENPP1NSFP1 LTN1 TMEM80 TRIM25 RP3-465N24.5 COA3 B4GALT2 TIMM8B VWA8-AS1 UBE2MFBXW11 HLA-A OSGEP ACBD5 RP11-216B9.9 C15orf40 ARHGAP11B PYCARDRP11-465N4.5 HINFP MGME1 CTD-2545G14.7 RP11-378E13.3 RPL5P34RP11-81H14.2 RP11-855A2.1 APTX MRPL33 RP11-15A1.7 PTGES3 DNAJB5AC087294.2 ARF5 OSBPL8 RNPS1 RP11-1072A3.3 PANK3 RWDD1 Metazoa_SRPIRF2BP2 CBX3P2 CDKL5 RP11-525G13.2 CEP68 SEPSECS JAK3 TIMM50 FAM120AMLC1 NUDT16L1 DCAF13P3 YAP1 HCP5B SMS SLC35E1 SIRT7 ZNF491 SPDYE5 NABP2ZNF367 SP2-AS1 URB1 VARS2 CENPT TAF1 DNPEP CRIPAK UBOX5 RP5-1185I7.1CCDC62 RP11-304F15.3 REL CEP95 AIG1 MAP3K12 UQCRFS1 SIGMAR1 RP5-1160K1.6RP11-293M10.6 IFNB1 NHP2P1 DPP3 STK32C RP11-295D4.3 RP11-476C8.2 NDUFAF2MRPS30 RPSAP41 PANK1 UNG EFCAB11 LLGL2 PDCD10 ST14 TMEM191A CD53 ACLYCOA4 CTD-2350C19.2 SPIN2B AC008746.5 TMSB4XP4 MED4-AS1 MTG2 RAPGEF2TMEM184C PIM3 IGLV6-57 ARPC4 TUBD1 NEFH MT-ND5 RP13-104F24.3 HKR1RP11-130L8.1 GDAP1 SNHG17 GLS ZNF829 FARS2 FAM208B LRRC37A17P RGS19SERPINB1 REEP2 MTERF1 CORT AC005154.6 ARFGEF2 FLJ20021 EDEM2 ANKRD26P1CITF22-49E9.3 IGKV2-24 IFT122 BMP8B MFNG PTBP1P TYW5 CETN2 RP13-672B3.2STAG3L4 SMUG1 CMPK1 PRPF39 PER3 ARID4B RP11-732A19.8 AHI1 PVRIG FAM69BEIF3C RP1-101K10.6 ZP3 NEMP2 AC026150.8 MRS2 ATP5G1 CISD1 RP11-706O15.7ZNF800 NAIP SLIT1 IGLV3-1 COA5 CTD-3092A11.1 RP1-191J18.66 AP001056.1LRRC28 INTS2 TSPYL5 RP11-419C5.2 NUP88 FP325331.1 ZRANB2-AS1CTD-2517M22.17 ZNF805 CCDC102A SNAP23 C5orf15 PHF11 TIMM44 RP1-228H13.5PTPN13 NARS PNLDC1 GXYLT1 EID3 UPF1 HCG2040054 RP11-321A17.6 HAUS3C5orf24 RP11-240G22.5 ZFPL1 MRPL50 TRIP10 LEPROT PCP4L1 PKDREJ FTH1ZNF197 ANKRA2 ZNF783 TYROBP CTB-193M12.5 SCYL1 VN1R81P PLA2G4C SUCLG2LYSMD3 OGDH DNTT EFCAB10 TMEM38A ZNF362 TRNT1 TAPT1-AS1 CELF5RP11-343H19.1 ITGAE MIR3179-3 PURB PDE6A CARHSP1 RP11-458D21.1 MBLAC1MTND5P28 OTUD6B-AS1 RABGAP1 TXNL4B RP11-79O8.1 ZNF815P PLA2G10 GEMIN7CHEK1 AP5M1 AC092338.5 TCEB3-AS1 ATP1A3 USP19 LRRTM4 MAP4K2 U47924.27SGPP2 PCSK7 KPNA1 FAR2P3 SDHAF2 GMNN EXTL2 PA2G4P1 AMIGO3 SMIM14 PRPF19FAM32A RP13-638C3.4 HEXIM2 ZCCHC4 RPL35 ZNF19 FGD1 GAMT RP1-228P16.8NDE1 RP11-109G23.3 KCNJ13 ANKHD1-EIF4EBP3 PRRT4 TANC1 EIF5BRP11-318A15.2 PPDPF RNFT1 RAC1 SLC25A1 RP5-855D21.3 MRPL16 DAG1RP11-1167A19.2 RP11-231I16.1 RP4-671O14.5 FASTK RP11-640I15.1 LRRIQ4RP11-267M23.1 CLSTN1 FAM120AOS CCDC85B AGAP2-AS1 TMED7 ARPC3 PHF20RP11-429D19.1 NSL1 ST3GAL4-AS1 WDR5 RAD23A MTND6P4 ARMC10 PEF1XXyac-YRM2039.3 DHFRL1 EIF2D MRPL23 ALG13 MRPL44 RAET1E HSPBP1 EPHB4MAFF MAMDC4 NME4 C20orf24 CREB5 RP13-104F24.1 BOLA2 FCHO2 FAM129A HTRA4RPAP2 ARAP1-AS1 HYKK HMGCR TMEM44 DCTN2 VDAC1P8 IARS2 TLK2P1RP11-545I5.3 RP11-127B20.2 ARPC2 CCT6P3 SAMSN1 MFAP3 NOSTRIN FANCARP11-163E9.2 LINC00865 OGFRP1 CISD2 GGT6 ZNF219 TIPARP-AS1 USP40RP11-266L9.3 MTHFD1L RP11-66N11.8 RP11-638I2.2 ZNF391 SUN1 EARS2 CD68NOC2L RP3-408N23.4 RP11-313P13.4 FYTTD1 CTF1 TIRAP APOBEC3F FAM223BFAM223A AC023590.1 TM4SF1 RAB44 EXOSC6 RYR3 RP11-114N19.3 HYI REEP5CTD-2199O4.7 EXT1 CEBPZOS RP11-229P13.2 CHIC2 RP11-398A8.1 TOMM22 AGBL5ZFYVE9 TMEM39A RP11-388C12.5 PDCD6 LYST ATP6V1E1 STAP1 RBAK-RBAKDNRP11-165F24.5 AREG PPIL2 ZNF788 METTL2A TMEM9B-AS1 PAQR5 HSPD1P10 PPP6CBCKDK PSMD7 RP11-524O1.4 PTPRJ CH507-9B2.1 KPTN RAB14 SPDYE2BRP13-890H12.2 SLC30A7 POLR3K MRPS31 SHISA5 SPIN2A STXBP3 TMEM106CZDHHC23 DRG1 CTD-3224K15.2 ITGB7 PALLD AAMP COG1 C16orf91 Metazoa_SRPRHD ELF4 RP11-306G20.1 RP11-159F24.3 TMEM60 BAG1 AC083843.1 S1PR2RP1-148H17.1 RPSAP26 SLC7A5 KB-1507C5.4 CTDNEP1 SNAPC1 BCAR1 PSMA6P1AC012363.8 EIF4BP7 EP400NL RNF222 A2M-AS1 RP11-738E22.3 AC093627.9ZNRD1-AS1 OACYLP AC068831.15 CSAG1 AP000648.5 ZNF514 GRB2 GBA2 SAR1AZNF774 LINC01225 RP11-464F9.20 CARNMT1 AFG3L2 APRT ZNF768 MEF2A ESDAP000295.10 RP4-635E18.7 MATN2 SPOP ANKRD36C GPX7 AP000769.1RP11-555K12.1 RP11-337N6.3 MCCC2 PMS2P1 RP5-1039K5.19 ATP5G3 SCFD1 SAP25WNT5A RP11-580I16.2 SLC46A3 SLC23A2 STXBP5L INADL ENDOG NIPSNAP3AKIAA1462 TLR1 TMEM109 CTA-414D7.1 ZNF589 DPM2 NKIRAS2 NR2C2 NINJ2 PGAM4GUK1 SCAND1 MAPT HIC1 IMPG1 LINC01063 ZBTB34 AC005822.1 AC098820.3ERLEC1 NCAN RPL36AL AP000349.2 DNAH2 TMEM249 RP5-991G20.1 RP11-803D5.1EXD1 ALKBH1 FAM87A SUCLA2 RP11-567M16.6 TIMM22 PRKACB RASIP1 C2orf50HEMK1 DCAF4L1 DNAJC27 RP4-530I15.9 NIPA2 RN7SL333P RP11-552F3.4 COX19ABI3BP RP11-507K2.6 MUSTN1 SLC38A9 ZC3H12A NTPCR ZNF185 LIN7C AC009501.4NRSN2-AS1 TAS2R14 FAM72B ANXA2R MBD1 C22orf39 DNM1L RP11-574F11.3 PDSS1TGFBR1 NRBF2P5 COQ2 RP13-192B19.2 RP11-358N2.2 KLHL28 VDAC2 LILRA6AC135050.5 PSAT1 C14orf37 CTD-2622I13.3 CCNB1 MYDGF RP11-435O5.6 GCDHUHRF1 ACTG1P20 RFC2 CTC-451P13.1 GPATCH8 STK10 MYBPC3 RAD51-AS1 F8C3orf17 GRIN3A AC006116.17 SPTLC1 ZNF680 INSM2 RP11-255E6.6RP11-192H23.4 RP11-799B12.2 KHDC1L WIPI2 MRPS5 PSME2P2 HOOK2 TRIM61LMBRD2 LRRC37A4P AC004893.10 CATSPERG Mar-02 AC024560.3 RBAK SLC9A1KIAA1328 GJC3 MRPL47 RNASE4 LYRM5 IMPDH2 RP11-50I19.2 FOXP3 NDUFAF7RP11-109N23.4 TMEM50A RP11-384K6.8 RP11-356I2.4 CBFB RWDD4P1RP11-547D23.1 CD55 RP11-474L23.3 RAB5A RALA HHEX EEF1A1P12 MRPL20 TMIGD1RP11-266L9.1 RP11-697E2.6 CCDC124 GOT2 AGL PIK3C3 CYP51A1-AS1CTD-2553L13.10 AC005785.2 AC027612.6 RP11-316M20.1 KLHL3 AC104653.1RP11-488L18.8 SPTBN1 LRRC37B ANXA6 METTL22 HMOX2 RPL9P25 SEH1L SLC15A2AP001059.5 FAM200A ANAPC1P1 RP11-778J15.1 SVILP1 RNF166 C12orf10 FAM135AARAP2 DAB2IP METTL14 LNPEP MYL9 SPDYE11 PAXIP1-AS2 DUSP2 NKAP TMEM218C16orf70 IL32 PFKFB2 UBE2T TMEM43 RP3-329A5.8 SULT1A2 ZNF750 PRIMPOLNTNG2 GEN1 ERVFRD-3 ARPC1B RP11-697E2.9 SRRM2 RP11-25L3.3 DNAH1LINC00355 KIF3B FAM188B RP11-496I9.1 SIN3A RP11-277P12.20 RP11-345J4.1PARS2 MTPAP STAR NADK2-AS1 BEST1 CEP44 SURF4 AF131215.4 AC012123.1SLC5A10 RP11-286N22.14 RUNDC3B LINC01337 TXNRD1 PTGES2-AS1 SUCLG1 VMP1MAGEA12 POU5F1P6 RPL18AP7 RASSF1 THBS2 WRB MTCO2P12 AP000437.3 FAM98CCOQ4 RP11-596C23.6 PRSS27 ARL16 MRPS36 RRH CACTIN C4orf26 RRP1 MROH8CTB-152G17.6 METTL6 CEP120 COX7A2 RCC1 CCDC85C RP11-260M2.1 AC092667.2ALDH3A2 IGLV1-47 HTR7P1 LEPROTL1 ZNF787 TMEM208 CHID1 WDR36 EFHB SELOKB-1440D3.13 HLA-F PDE4A RPL23AP10 RAB7A ZFY-AS1 PGF SHMT1 RBM44 MED15OSGEPL1-AS1 ZSCAN29 RP11-490K7.4 UCHL5 RP11-242C19.2 RP4-569M23.4RP11-6N17.3 RP3-508I15.9 RARS2 ATP13A3 Sep-15 CHMP6 MTMR7 TBC1D29 TMX3MPP7 CRK RP11-138I1.4 PAPD4 BSCL2 CTD-2587H24.10 RPPH1 TOR2A STARD3C5AR1 GS1-393G12.13 CTC-457L16.1 TGFBRAP1 AC135048.13 RP1-292L20.3ZNF724P RP11-798G7.6 RNF4 TPRG1L PDIA3 SNHG20 AC105760.2 PHB2 COX4I1FAM49B CEP192 HSPA9P1 ARPC5L ZCRB1 ZNF319 IER5L SQLE ZNF317 CFAP43TYRO3P KANSL1 SH3RF1 RP5-908M14.10 SMAD5-AS1 ELK4 RP11-10O17.1 HSPA1BLINC00431 TPST2 NUDT15 ASPSCR1 NPEPPS ARAP1 ZNF773 NAV1 CYB5R4 SC5DKPNA4 HEY1 RP11-474G23.1 COTL1 RP5-1014D13.2 DAGLB CTD-2342J14.6 IDI1AC116366.6 URGCP ABTB2 CEPT1 MLX SMG1P5 UBE2L3 SLC10A1 ZSCAN25 RFKWDR11-AS1 POLE2 CHST11 GADD45GIP1 HSPB11 TOMM20P4 HADHA RP11-53I6.4CTC-277H1.7 PTS MRPL18 TOP3B SYT16 MRPS18C LMBRD1 TTC30B RP13-977J11.2MUTYH PSMA3 TMOD4 MCC CTD-3126B10.2 AP4B1 RP11-81A1.3 CUL3 SLC25A17POLDIP2 ELOF1 WDR54 RP11-861E21.2 AC009473.1 RP11-977G19.5 IRAK1 WNT10ARP11-121M22.1 DKFZp779M0652 RP11-1072C15.4 RP11-51O6.1 THAP7 IGHA2 VRK2STRADA ENO2 SLC41A3 ST3GAL1P1 ITPRIPL1 RP11-317N8.5 ACSS2 RSAD2 RBM3RPS11P6 ZNF44 DEPDC1 MAB21L1 SMIM11B ERVH48-1 NDUFA5 RP11-504P24.9TMEM120A RP11-297N6.4 RP11-307E17.8 MT-ND1 PCYT1A GPALPP1 C1orf162 WWC1RP1-265C24.5 CTB-39G8.3 PCDHB2 ERO1A RP11-84G21.1 PTPN1 RP11-403P17.4CD74 RRP1B RP11-408A13.3 AC010468.1 MKRN2OS LINC01001 AC002310.10 FAM81APTTG1IP GPX1 GUCD1 C1orf35 CTD-2270N23.1 DCP1A RTTN IDUA RP5-1041C10.3PSME2 NT5C3B SLC5A11 CDC34 THAP9-AS1 L3MBTL2 DDX28 AKAP10 SRD5A3-AS1ATP5O ADAM21 GET4 C7orf31 HPD GACAT2 PRELID1 C1QTNF9B-AS1 RPL23AP24SRRM1 OIP5-AS1 IL12RB2 RILPL1 TMEM70 ATP6V0C CHRFAM7A CYHR1 CHAF1B OS9ARHGEF40 OSBPL10 SLCO4A1-AS1 RP11-384F7.1 A1BG-AS1 C22orf15 LRG1 RTCAFBLN1 TBC1D25 CTC-487M23.6 TSNAX PLP2 BTN1A1 RN7SL608P TMEM259 WDR92MROH2A UGDH-AS1 RHOQ PSKH1 XRCC6BP1 RP4-758J24.6 LYRM1 SNX20 CDC42SE2LETM1 SMIM4 RP11-66B24.4 RP11-589M4.1 CD8A SLC25A14 ARHGAP4 CTC-453G23.7ZNF337-AS1 SCARF2 AP1S3 SNX5 RP11-642A1.2 KIAA1715 CACTIN-AS1 QARS UBTD2CTB-75G16.1 KLC1 GOSR2 SPINT2 UNC50 TRAPPC2P1 CAMTA2 TYW3 CNBD2 ANKZF1CFD PLEKHA2 ACVR1 SLC25A23 FAR1 ALG6 RP11-342M1.3 CD3EAP RP11-430G17.3ZNF547 RP11-342K2.1 MMGT1 KRT9 BRMS1 SLC27A1 COX11 NEK9 CTD-2650P22.1PKN1 RP11-831H9.11 STYXL1 RP1-199J3.7 EPS15L1 CEP170B CAPNS1 ARF6COL4A3BP SBDS PA2G4 CBR4 CUL5 PPP1CC RCAN3 INPP5B CEP162 CTC-512J14.5AGAP9 AMD1 CBWD1 CTB-50E14.5 ZNF302 PLXDC1 PTGES3L MINOS1 PYROXD1SLC38A7 NEURL2 CXorf40A SRP68 ANAPC11 PACS1 PTGES3L-AARSD1 XXbac-TBC1D12 BPG157A10.21 TAF1A ACSF2 PET100 DARS RP1-309F20.3 AIFM1 MAST1LRIF1 FAM122A RP11-822E23.8 HOXC9 FN3KRP STAM2 FLNB-AS1 RIOK3 UTP11LMAN1B1 PGLS RIPK2 UBE2V2 RP11-380O24.1 CRIPT RP11-93G5.1 MSL2 CCZ1 WDR24RP11-166A12.1 ZBTB16 TTC28-AS1 RP11-506M12.1 OTUD4P1 FAM13B RP11-534L6.2RP11-453E17.3 KL CACNB3 HS2ST1 HIGD1AP1 VPS11 MACF1 RP11-1149O23.4 AESCEBPB ZFR SFXN1 RP11-936I5.1 ZMYM6 SUGT1 LCA5L CRAT AP2S1 FBXO2 MMP15DNAAF2 RP5-1099D15.1 SESN2 MIR155HG USP30-AS1 ILVBL AC093690.1 TPMTEGFL7 WDR25 C6orf203 MIEF2 FLJ30679 SPDYE9P CTC-756D1.2 RP11-950C14.3RP11-481C4.2 BNIP3P1 RASSF5 ELOVL5 RP11-381E24.4 MRVI1 RP11-337N6.1CASC1 SMIM19 AL133243.2 CXorf56 NEK10 PPP6R1 SOCS5P4 RP11-982M15.2RP11-439E19.7 TAX1BP3 MRPL11 RP11-394O4.3 SRPR TMEM11 ANAPC16 ZSWIM8-AS1SLC1A4 NDUFA6-AS1 ZNF346-IT1 SPRYD7 TTLL1 RP11-867G23.3 AC010976.2DCUN1D1 C19orf70 FANCB PCDHB11 KANSL2 JPH3 IP6K1 TGFB2 ETF1 CCL28 PCYT2AAGAB CTD-2196E14.7 EFR3A NFS1 CTD-2313J17.6 MPP6 RP11-378J18.8 SCO2FUCA1 CTD-2278110.4 NAA40 ZBTB47 RP11-479G22.8 DIABLO GPN3 MTND4P26 CNSTMYCBP2 BRI3BP SLC25A5P1 CYB5B RP11-392O17.2 FAM166B TNIP1 TMUB2 CCDC86EPSTI1 LA16c-306A4.1 CTD-2184D3.5 ALOX12 ASB14 AC136289.1 CTD-2358C21.5CCDC18 SLC7A6 RGS18 RP11-251G23.5 DAD1 PPP3CC TBC1D19 FAM229A FRMD5CASC4P1 CDADC1 NARF SNCB DNAJC28 RP11-473M20.9 MEFV EML6 AC000123.4LINC00957 DNM1 NUBPL CTA-984G1.5 MRPS35 C6orf120 C11orf71 RP11-18H7.1CTB-92J24.2 CTD-2330K9.3 RP11-505K9.1 RP11-77H9.8 ANKRD28 RP11-381E24.1BPTF STK25 AP001962.3 TMEM253 SPDYE3 ZNF584 MALSU1 MBLAC2 KAZN ATP5HEEA1 TBCCD1 PMS2P4 BIRC5 KIAA1919 XX-FW83563B9.5 AHCY AC005519.4RP11-345J4.3 RP11-434P11.2 MRPL22 TUBGCP6 AL592183.1 KIRREL2 FAM27E3PMM1 RP11-958N24.1 RP11-371E8.4 RP11-15J10.1 C16orf71 SLC25A13 PCIF1RALGDS BAIAP2L2 RP11-158H5.8 AC002467.7 PDAP1 UFM1 SETDB2 MEN1 HOXB7DIS3L RP11-7O11.3 RP11-428G5.5 OBSCN AASDH C10orf105 C1orf233 ANKRD20A5PDTWD1 SIRT3 LINC01424 TPTE2P5 LA16c-380H5.5 RP11-336A10.2 ATG4D TUBA1CGSR PLIN3 ZNF761 HNRNPA3P9 TMEM87A DLAT CTD-2012K14.7 PTRF ITPR3 STX16RP11-34P13.14 RN7SL1 ANO7P1 MVK CCDC59 GOLGA8B GYS1 CEP104 PCMTD2 SLC7A1ANKRD13A FAM174A RP11-57H14.2 M6PR CDC42P6 GRPEL2 XRCC1 AC007192.4 CTBSCEP83-AS1 JUP TBRG1 SPOCK1 NIP7 RNF113A MARCH1 TMEM256 QTRTD1RP11-314A20.2 TAF12 LRCH1 NUDT18 CTNS ZNF638-IT1 BSN PPIB PMS2P7C9orf152 POP4 TTC41P RP1-55C23.7 FUT10 CANT1 AMZ2 NEBL AC005618.6 MDP1DGKE WDR78 ATL3 GCSHP5 CTRL ATPIF1 MAVS ATP5F1 SLC4A2 ZMAT3 PGBD4 MAP2K1TCIRG1 TIMM13 ABR SLC25A4 BNIP2 FRS2 LRRC59 PMPCA SP110 SPCS3 HMMR GPD1LERP29 RP11-73O6.3 PLEKHG4 MIR181A2HG CTC-444N24.8 RP11-399B17.1 LY75DDX10 RP4-784A16.5 AC002115.9 RPL9P29 PCDHGA11 CMC2 RP11-111M22.4 UHRF2RP3-395M20.8 CTD-2270P14.1 RPN2 NKTR ERCC6L2 ANKRD61 SELM CUL7 DTWD2NCR3 ARIH2OS GOLGA6L5P HESX1 PARP9 ZNF286A LINC00299 LYPLAL1RP11-325N19.3 TBC1D17 ARHGAP24 IFIH1 MTHFD2P7 SNORD22 GTF2H1 SARS2 DAND5TMOD1 RPRD1A JRKL AC004893.11 REEP1 TPCN1 RP5-857K21.4 EIF2AK2 OR7E38PMRPL32 ARMC2 RP11-158H5.7 C9orf142 RP11-175P13.3 WDR31 RP11-326C3.15ARV1 RP11-96K19.5 RP11-1072A3.4 CHCHD4 DENR EIF1AX TAS2R15P PRCP PUSL1CTD-3126B10.5 ZNF268 LPIN1 PRDX4 MRPS22 MTATP8P2 ERVK3-1 PPP1R15B MOCS2GNPTG ZFYVE26 AGFG1 RNASEK-C17orf49 RP11-299P2.1 DNAJC6 ADGRD1 TUBA8RP11-960L18.1 ISCA1P1 PTPRC LINC01136 RMDN3 RP11-282O18.3 NIPA1 ATP5A1P5GATAD2A CCDC39 DIP2C DMGDH FBXL6 CDC37L1-AS1 RNF43 USP53 ARL2BP ANKS6RP11-171I2.2 CCND1 TRDC GRSF1 N6AMT2 C8orf82 RP11-1149O23.2 VWA7RP11-766F14.2 CTC-492K19.4 WDR7-OT1 PBDC1 SLIRP SDR42E1 SLFNL1 KREMEN2RP11-307C12.11 RPS7P1 RP5-966M1.7 PPT2 XK RPS26 ANO7 C12orf60 TMEM50BRP11-727A23.1 DHRS12 DPM1 RBPMS GCSH GUSB AC011330.13 IGFBP2 ATP6AP1MNX1-AS1 AC068499.10 CBWD5 RP11-250H24.2 FUCA2 RP11-425D10.10 NUS1 IKBKGDFNB59 COL6A6 CD320 PPP1R3D TCHP TUFM ECH1 AAAS GPNMB DDX55 MOB1ATIMM17A GSN-AS1 CTC-265F19.3 TECR MFF COX5A IFRD1 RP11-666O2.2 STAG3L1THOC2 BRIX1 SLC12A3 TMEM69 DAP PSMG3-AS1 RP11-10C24.2 EEF2KRP11-793H13.8 MCOLN2 PTP4A2P1 RP11-250B2.6 SYS1-DBNDD2 BCORL1 HSPA8P8SLC14A1 ZNF550 GIPC2 LRRC18 RP11-658F2.8 OMA1 DERL3 TIMM21 RP11-729L2.2FGFRL1 SUPV3L1 CCDC7 TSN AL928654.7 CTA-363E19.2 HCAR1 VWA9 LARP4BRP11-67L3.4 RP11-819M15.1 KDM4D SPOPL MTPN C19orf52 CHKA PPIL3 POLR2EPES1 RP11-326I11.5 EMC10 AC133528.2 PLEKHA5 RP6-109B7.2 NDUFS7 CLEC16AXXbac- RP11-298I3.1 BPG299F13.14 NQO2 BCDIN3D PSD HCG27 CDKN2AIPNLRP11-881M11.2 NR4A1 TMEM173 RRS1-AS1 POLR3G DDT PIP5KL1 CINP TTC30ALINC00342 KCNA6 CACNB2 CAMKK2 TMEM30A SNX18P27 MRPL14 ARFRP1RP4-785G19.2 ZNF790 SSH2 PDRG1 RP11-10E18.7 ZNF324B HN1L CEBPE MCTS1RP11-500G10.5 SLC4A10 CTB-25B13.5 DCP1B CFAP44 NFKBIZ ETAA1 ANKDD1BCTA-445C9.14 ELP3 RP11-383I23.2 RP11-374F3.5 RP11-574K11.5 RP11-359P18.7SMC5-AS1 CTD-2349P21.9 MRPL13 ZNF304 AC087163.2 TPRKB RP11-66N24.4 CD86RP11-831F12.3 TFRC AIMP2 AURKAIP1 CTC-543D15.8 EIF4E1B RP13-395E19.3IFIT2 SLC39A14 VASH2 ALG8 CTD-2555O16.4 AP001505.10 RP11-338K17.6 RAB3ALSMEM1 RP11-219D15.3 DDHD1 RP11-563E2.2 DVL1 RP11-472B18.1 ESRP1 INPP1DENND1A SPTSSA DDX3X RPF2 NKX3-1 AF131215.9 IMPDH1 KANK1 DENND4ARP11-191G24.1 TOMM20 CHURC1 RP11-206L10.2 RP11-347C12.1 TMEM161B-AS1RP11-690D19.3 PPARD RP11-490G8.1 ARMC12 RP11-603J24.17 TMEM59 SH3D19NRN1 RP11-447D11.3 LYPLA1 RP11-661A12.5 MYBBP1A CEP83 RAB4A ZBTB25 CHPFUBR2 IRF7 AC108676.1 DEAF1 C18orf21 PSMD12 KIF4B DCTPP1 HIST1H3J PIGKRPUSD3 SLC35C2 C5orf22 RP1-29C18.8 DGUOK-AS1 VKORC1L1 RPP40 ALG9 DNAJA3ATP1A1 KHK RNF141 RPUSD4 RP11-1348G14.4 NR3C1 IPO9 RP11-752G15.10 LOXL4RP11-212P7.2 CKMT2 PPIAP11 FCER1G ZSCAN31 ABRACL LL22NC03-86G7.1 DNAJC5CEP290 AREL1 MCCC1-AS1 KTN1 ZNF124 MRPS10 PPTC7 PHYHD1 ZNF777 MRPL46LINC01237 CTD-2010I16.1 DLD OAT RP11-453N18.1 RP11-63A1.4 C12orf76 STMN3RECQL5 UBAP2 RP11-317B3.2 POLR3F CTD-3099C6.9 JHDM1D-AS1 CTD-3193O13.12DDX60 CS UBR3 RP11-218F10.3 CTD-2357A8.2 NDUFB10 RP11-767N6.2 NAPRTOSBPL3 LAMTOR1 ASIC3 CTA-228A9.3 CICP14 UPF3A TBL1Y JDP2 RPS3AP6 COMMD4VGF C11orf16 HCG4P7 RP11-421M1.8 ATG4B WDR6 RP11-88E10.5 BOLA3 ELLCTC-444N24.7 MRPL12 ESCO2 PMM2 FAM219B ST13P18 CTD-2231E14.8 CTB-180A7.6ARL5A TLL2 RP11-347I19.7 APOBEC3G RP11-263K19.4 RPL29P11 RP11-136K14.1APMAP THAP7-AS1 MZT1 UFL1 TMEM131 RP11-34P13.8 USP25 CTD-2349P21.3RPL7L1 SDCCAG8 ZNF839 PNRC2 ACTRT3 RFC5 RP5-1085F17.3 FAM3A SLC9A6DPAGT1 URB1-AS1 MPV17L2 SURF1 SLC25A38 FOSL1 NUCB2 RP11-101E13.5 CAPN1CES4A DENND1B PRORSD1P ZNF837 MRTO4 AP001189.4 PIDD1 IFT57 IZUMO4MAPK1IP1L EMC1 HOXA5 RPL7P50 SSFA2 SH3GL1P2 TMED8 HSH2D RPAP1RP11-342K6.1 ZNF700 USHBP1 RRM2B RP11-324I22.4 CTAGE7P CCNL2 FRYLTSC22D4 RP11-110I1.12 RP5-1042I8.7 RP11-761I4.4 CARD19 RP11-840I19.3C1RL STRN3 CDK14 HTATIP2 EBPL EBAG9 CAB39P1 PSPN NSMF TXNDC17 CUEDC1SLC39A11 ACOX1 SLC35C1 RRAS NDUFC2 ZNF84 RP11-131H24.4 NAGPA CENPK GCH1PRKXP1 RP5-862P8.2 PDE4C MRPL53 PIAS4 RP11-802D6.1 RP11-348P10.2 THADARAET1K RP4-775C13.1 MIA3 FAAP20 RP11-505K9.5 SLC35D1 STARD9 LST1 GNL1TDRKH EIF4A1P10 RP13-210D15.8 VMA21 CFB CASD1 BRCA1 ADAL WARS DGUOKC3orf20 EFCAB13 WASF2 HOXA13 HOXA10 TSACC GAS8 LSS KCTD13 MRPL38 ATRAIDEIF2B4 OXCT1 RP13-516M14.8 AGPAT4 RP1-97D16.1 SAMD12-AS1 CNEP1R1 CPT2SNRNP25 FAM91A1 LINC01215 SAMD8 SPIN3 RP11-20O24.4 TTN-AS1 DHX38LIPE-AS1 NOP14-AS1 TTC39C-AS1 RP11-400F19.6 TRMT61A TNFRSF10CRP11-274B21.9 RP11-474N24.6 RTN3 CLN6 ADAM1B TNKS2-AS1 IDH3G BCKDHBFAM72A SDCCAG3P1 AC023271.1 AC005786.7 ZMPSTE24 CCDC163P NOP56 C1orf122RBM47 RP4-622L5.2 CTD-2521M24.8 ABCC4 AC093818.1 PTER APEX2LLNLF-176F2.1 KLF8 CYB561 CD99P1 CD99P1 PLEKHF2 PORCN IGFBP6 PTBP3 EIF3IAGBL3 ADI1 RP11-656D10.7 HSD3B7 ICT1 LENG1 TSPY26P TIMM10B DUSP14 ADCY4CTD-3105H18.4 CCDC150P1 CIRBP-AS1 SNN RP11-435F17.3 RP11-138A9.2AC069282.6 SERINC1 RP11-722E23.2 ZRANB3 ATG13 RNASEK LMBR1 FAM157C CEMP1IGDCC4 ARHGAP8 RP11-166B2.3 THAP6 NUTM2A RTN2 RP11-783K16.13 PWAR6 KLBTHAP4 TVP23B FTSJ2 Sep-09 RHPN1-AS1 MPG RP11-12A20.4 SCCPDH RP11-4B16.1ABHD16A KB-431C1.5 RP11-592N21.1 QTRT1 RP11-186B7.4 TMEM242 GOLGA7RP11-16F15.2 UBE3A RP11-288C18.1 SOD2 RP11-66N24.3 ADPRHL1 RP11-120K19.3Metazoa_SRP RP11-93B14.6 BOD1 AC005606.15 SPIDR RRP7A MRPS9 TNKS COPS7AEFHD2 AC068282.3 SMG1P6 KDM7A NDUFA11 PA2G4P4 RP11-1099M24.6 ACOT13TMUB1 ZNF76 ZNF214 TOB1 RGCC CTD-3014M21.1 EPHX1 ACAD9 EEF1B2P6RP3-461F17.3 PIK3C2A RBBP8 RP1-100J12.1 FAM86DP ARL8B RP11-844P9.2ATG16L2 GLA MRPS28 RP11-575L7.8 TMED10 SEC11A ABCF2 EXPH5 TMEM185ATALDO1 TMEM167B RTP4 STARD7 RP11-697N18.4 TMEM120B CSPP1 TAP1 TAOK3 CTHPCDHGB4 C9orf3 DPY19L4 RBMS3-AS3 SYPL1 VWA8 TNNI2 MTMR11 IMP4 DGKZP1SRD5A1 NAPA RP11-342K6.2 IFNAR1 CTDSP1 SAMHD1 AC009404.2 VCLRP11-819C21.1 MAP3K6 PPM1K KIAA1841 MARVELD3 RP11-274B21.12 RP5-1050D4.5GSN RP13-923O23.7 CNTD1 RP11-449J21.3 ORMDL1 PPP6R2 PLAG1 CATSPERBSNAP29 RP11-532F12.5 SLC31A2 RPP25L ZNF446 FAM173A PRMT1P1 GPAA1 POLBNBEAL2 RP5-821D11.7 LRRN4CL GRIP1 TMBIM6 TOB1-AS1 TOMM40 CIPC ETNK1C1orf123 ARG1 STON1 RP11-20B24.4 PICALM TMEM260 PAXIP1-AS1 RP11-21K12.3RN7SL268P DLX3 DOHH AC007318.5 PCCB CLN5 KDELR2 TMED3 BMPR1APS2C14orf119 STAG3L2 SPRTN ANKRD27 ANKS1A HMGN2P46 PIK3CD-AS2 SEC22ARP11-697E22.1 ASS1P2 GCA XPC UBE2K PLEKHB2 RP11-196G11.5 RBFARP1-72A23.4 CTC-429P9.5 CTD-2260A17.2 LL22NC03-2H8.5 ZNF217 CLK4 RPS7P10TIPARP BCS1L POLR2L DRG2 RPL12P16 DNAJC15 SPAG1 FBXL17 TP53I11 FLRT1RP11-574K11.32 FBXW9 RP11-600F24.7 GOLT1B TXLNGY MT-ND4 ZNF169RP11-75C10.6 SYTL2 ERBB3 AC010894.3 KRT18P63 CRELD2 TEN1 GHRL CXCR5OR7E47P ACOT2 RP11-661A12.12 C11orf45 CDAN1 TUBB8P1 PPP1R7 PCYOX1 CCDC64RSPH9 SLC9A8 H3F3B CTC-529I10.2 MCOLN1 MRPL17 ZNF266 GANAB GTF3C2-AS1LAMA3 RP11-795H16.2 UBTD1 ZNF182 NSA2 CHRNA5 ANKRD37 SLC25A30 AC074286.1CTD-3184A7.4 SZT2 ZBTB44 RP11-996F15.6 PITPNB CYB5D2 TLR2 CALM2P2 MTDHREXO4 SOS1 GPAT4 LAPTM4B RNF39 TM9SF4 AP003774.1 RPL9P7 FARP1RP11-645C24.5 AP000223.42 NUAK2 CTD-2410N18.3 RP11-517B11.4 C14orf1TULP3 TMEM214 KRTCAP3 RIBC1 SMO PURA RP11-390P24.1 TRIM23 TFEBRP11-31F19.1 ZNF295-AS1 HDAC10 EPB41L4B GTPBP10 ST13P4 CTD-2001C12.1PRR22 SNX25 RP11-245D16.4 RP11-320M2.1 RP11-783K16.5 MTND2P28RP11-1007O24.3 RP4-682C21.2 TRAF3IP2-AS1 ZSWIM6 C17orf97 RP11-347C18.5KLRG1 PGAM5 RP11-230F18.5 RP13-254B10.1 TXNL4A TANK FOXRED1 EPT1RP11-93B14.10 PGAP3 PDIA6 PSEN2 NRM CTB-79E8.3 DTYMK VIMP VPS25 NKAPP1C17orf51 LRCH4 TPGS1 SNX18P9 SAMD13 AC005540.3 RP11-165E7.1 PLD6LRRC37BP1 CTB-26E19.1 ZNF585A POC1A MED11 AC010226.4 WDR43 CHKB-AS1 REV1CRIP1 GUSBP3 IMPAD1 LINC00843 RB1 CTD-2506P8.6 VPS37C BRIP1 PMFBP1UBE2G2 C19orf12 RP11-56B16.2 TMEM101 IKBIP PICK1 ACADM SNX29 UFSP2 DPEP2FBXO42 ERMAP NDUFAF6 CCDC146 TMEM68 RP11-499E18.1 TPK1 XPA CH17-260O16.1EMC7 QPCTL GMPPB PITPNA OLFML1 RP1-138B7.7 MME TMED2 RP11-632K20.7ATP5A1 RP11-152N13.16 LINC01353 RP11-278C7.1 DDOST RP11-467P9.1RP11-435D7.3 RP1-239B22.5 CTA-29F11.1 COL8A2 CTD-2619J13.17 CLDN20CTC-429P9.3 FGFR1 RP11-1379J22.2 SENCR MDN1 ZNF726 CNTNAP1 NASP UNC93B5TRAP1 CTD-2574D22.2 SHB RP11-231C14.7 CTA-384D8.35 RABEPK SLC25A15SOWAHD PLCXD1 PLCXD1 TLK2 CTD-2017D11.2 RP11-332M2.1 FAM122B ZNF827RP13-104F24.2 RP11-118K6.3 CTD-2574D22.4 RP11-530C5.4 AC007383.3RP11-218L14.4 RP11-259K5.2 HAUS6P1 HINT2 LIAS RMI2 ZNF423 ZNF69AC007192.6 IGLV7-46 PROX2 RP13-216E22.4 MRPS18A BCAS4 IFRD2 NAIF1 TRIM14KAT2A FAS RP11-77H9.2 VPS52 RBMS3 RP11-632C17_A.1 FANCM DEPDC1-AS1AC012358.8 MTFMT COMTD1 RP1-20B21.4 RP11-757O6.6 RARS PPP2R5E TDRD12MAP2K2 TCFL5 ISG15 TPI1P2 SDC3 C6orf89 RPA3 TRIM31 HNRNPA1P49 DPH2 CCNHKLF16 DOLK GYG1 RP4-800G7.3 FAM73A MTMR3 DYNLL2 MRPL10 STX4 FCF1P2ATP6V1H ZNF836 WRN RP11-48B3.3 MYL12BP1 PKIA-AS1 TMEM198 RPL21P28 USP15LLNLR-276H7.1 KIAA1161 PHF21A MLST8 RUVBL2 PDZD9 SCUBE3 SLC25A36 CCSTLR3 MFSD11 RP11-983P16.4 STRBP RBM18 CTD-2623N2.3 SPDYE10P MILR1 APOL4NHP2 AC090945.1 NME9 SETD7 ADIPOR1 NT5C3AP1 TEX9 FOXN2 GSS SERPINB8SH2B3 RP11-353N14.2 CCDC125 TMEM128 UBALD2 ZDHHC4 C12orf71 AC002116.7FBXL19-AS1 UBE3B SPATC1L CH17-431G21.1 WDR75 ZNF576 RP11-226M10.3 ARAFAC097495.2 ZNF678 RP5-1148A21.3 RP11-731C17.2 APPL1 MFSD5 OXCT1-AS1COX16 BOLA3-AS1 RABL6 NDUFAF3 NPM1P9 RBM33 RP11-65L3.2 RP11-411B6.6AGPAT5 C16orf95 ZNF530 CTD-2006C1.13 GIN1 BCRP2 XRRA1 TBX6 CTD-2017F17.2FAM47E SOGA1 TCEANC2 ACAP2-IT1 CTD-2012J19.1 ZFY ORAI2 LMF1 CHL1 ATP5EP2AKT1S1 MSS51 SLC35B2 FCF1 ANKRD20A18P AP1S1 LINC00116 C19orf18 TP53TG5ORC5 CEP41 ITM2C ZHX1-C8orf76 TTYH2 SIRT5 FRS3 PRR7 C10orf54 NSMCE1PDE9A ZBTB10 LINC00205 INE1 RP11-131M11.3 TMEM106B IRF2BPL RP11-50B3.4TRAF5 UBAC2-AS1 AC011999.1 NDUFB5 MUL1 ZC3H8 NAGLU SGTA FILIP1 CCDC22LINC00106 LINC00106 ZNF582-AS1 COMMD8 RP11-166P13.4 WWP1 CTD-3234P18.6TEX264 RP3-337H4.9 GHDC SLC25A19 LINC00337 CTGLF12P CALML4 SAMM50 TAOK2DTNB RHOF RP11-73M18.8 CCDC117 SP140 BX322557.10 SLC43A1 MFSD12RP11-448G15.3 HN1 CTB-36H16.2 NEB CHCHD3 ASTN2 PHTF1 PUS1 ANKRD39RP11-278J6.4 GTDC1 FAM227B FTCDNL1 LRRC4 INTS8 CCDC51 MOB3A B4GALT5RP11-1277A3.2 SLX4IP PYGO1 HIST4H4 KIAA0895L SUMF1 BNIPL ZNF341 LILRA2PEX12 TMEM138 RP11-12J10.3 LCTL PRG2 APBA3 UGGT2 COMT RP11-434B12.1TAF13 SMIM20 TRIM47 RP11-950C14.10 SIVA1 ANKRD20A1 CELSR2 FAM210A MRPS12MBNL2 NPRL2 RP4-657D16.3 RP11-93B14.9 PSMC3IP PABPC1L RN7SL481P CDKN2BPIGQ PTPN2 VAMP8 MBD2 SPAG8 DERA SDCBP2-AS1 LINC01277 CTC-360G5.9RP11-110G21.1 TOPORS-AS1 TIGAR TMEM184B GPR107 MT-CO1 TRIM4 SYNGR2HNRNPH1P1 TMEM147-AS1 HSPA1A TMED1 TM7SF2 ZBTB41 TMEM53 AGRP MTFR2 STAT1AMY2B SRD5A3 C21orf59 AC004067.5 LHFPL2 TRIM67 LMAN2L NUP85 PNKDADORA2A-AS1 NDUFV3 ASAH1 LARS2 RP11-10C24.3 ITPKA TAS2R20 HMBS ZNF582C3orf33 ALDH3B2 SAC3D1 DSCR3 C17orf96 PSMB8 RP11-274B21.14 AKAP9RP11-68I3.11 CHKB LGALS8 CTD-2600H12.2 CCDC96 CCNC PPP1R32 ROCK2RP11-382A20.3 PXMP4 MIER2 AP000240.9 AK2 ARMC10 TMX2 RP11-617F23.1DNAJC5B FLOT2 CTC-444N24.11 RSPH3 Z83851.4 AP3M2 RP11-370A5.1 CAB39GABPB1-AS1 HARS2 MED14 RP11-11N7.5 FGD3 ZFP41 TMEM192 ZNF852 NLN DNHD1SNX33 NR6A1 METTL8 C19orf60 FBP2 NAPEPLD SUV420H1 CDH13 LINC01004CTD-2547L16.1 ATXN2L RP11-73M18.6 KLHL21 NLRP2 NNAT STK19 TUBG2 TMEM237CD46 GNPAT KB-226F1.2 STEAP4 BORCS8 CTC-338M12.4 PEX26 CTD-252513.6L3HYPDH RP11-400F19.18 STRIP2 RPSAP12 RP1-198K11.5 TXN2 C10orf128RP11-174G6.5 RP11-552M11.8 RP11-121C2.2 ATP5HP4 CPT1A SH3BP5-AS1 SNHG16RP11-568N6.1 YIPF2 TBC1D22A TFPI2 RP11-407N17.4 BCO2 ENTHD2 APPBP2RNMTL1 SHC4 MIR17HG LYRM7 UCHL3 RP11-1149O23.3 FOPNL C16orf13 GNRH1TFDP1 C12orf66 TMPPE RNF135 VPS9D1-AS1 PSMG1 TSSK4 RP11-44M6.7RP3-508I15.19 RP11-345K20.2 RP5-1187M17.10 CTD-2650P22.2 KXD1 C12orf45ANKRD30BP1 DNAJC24 VOPP1 ANKRD19P PLA2G15 C15orf56 ZCWPW2 ASIC1 CEL DLSTTRAPPC2L NT5C1B NEDD8-MDP1 DOC2A PTPN6 TMEM156 IDI2-AS1 RP11-442N24_B.1SGK494 CYB561D2 MYCBP RP11-655M14.13 NEU1 CARD8 RMND5B HLA-F-AS1 RBFOX2RNF167 TMEM86B LRRC37A3 RP11-12M9.3 BET1L MRPL45 SPR TRPV1 NAT9 PORRP11-468E2.11 SLC3A1 ZDHHC7 RCE1 TMEM150A RP4-614O4.13 SLC8B1 MSRB1RP11-80H18.3 USP35 ZNF813 RP11-73M18.2 ZNF260 RP11-379F4.7 RP11-192M23.1RPL4P6 UQCC2 RP11-705C15.3 MFSD1 HIVEP1 DOCK9-AS2 ZBED6CL NEDD4L EIF2S1TRAF1 CES3 RP11-420K14.6 CSTF3-AS1 AC021188.4 CTC-471J1.8 RP11-304L19.12RP11-817O13.8 C22orf46 NSUN2 ZNF383 SLC30A6 HDAC3 UBL7-AS1 LINC00920CECR7 RP11-563J2.3 RP11-90L1.8 H2AFJ APOOL RP11-7F18.2 PAPD5 SLFNL1-AS1RGL2 CAD ACVR1B BIN3 YIPF4 GINM1 SLC35F6 KIAA0753 RP11-1020A11.2RP11-712L6.5 ZCWPW1 RP13-514E23.2 SLC25A26 AHSA2 SLC16A14 RP11-177B4.1BBC3 RP11-284B18.3 KRBA2 ASL RP3-405J10.3 RP11-141B14.1 CDK4 BECN1 SWI5ICAM4 ALG10B SLC27A4 FGFR4 SLC51A RP4-798A10.2 NAA35 SNRNP27 CCZ1BRP11-697N18.3 ABHD10 PCDHGB5 CA9 IFT74 CIB1 COX14 TATDN2P2 LMNA PCDHGB3RP11-546D6.3 LDHAL6B AK5 RP11-79P5.10 PKIB UIMC1 SP140L WEE2-AS1RP11-48B3.5 RABGGTA CTD-253719.13 CTC-241N9.1 SNHG3 MRPL30 PGAP2 ANGEL1MEMO1P1 IL17RC FOS CLCN4 ZBTB45 NFIA SP100 MBD5 TMEM97 CLDN15 PPFIA1RP11-106M3.2 RP11-196G11.4 TAF9 GALE C1GALT1 CHCHD5 HCCS LINC01572TRAPPC9 ZNF26 C15orf65 BCKDHA CTD-2410N18.4 PRDX2 STARD4 IPO7P2RP11-523O18.5 CELSR3 TUBGCP4 PUS7 CSTB GNL3LP1 RP11-360L9.4RP11-407N17.5 ORAI3 RAD54L LRP4-AS1 MMP25-AS1 NPIPB11 MTTP U2AF1 TXNDC5C2orf16 RP11-299J3.8 PAFAH1B2 MDH2 NT5C3A SWSAP1 ERICD RP5-1039K5.12NCKAP5L HEXA CFAP36 RP11-16E23.5 CREBZF RP11-211N8.2 RP11-373L24.1 ITCHTRAF7 HACD2 SLC12A5 GSTK1 AC024592.12 PSMD6-AS2 FSBP IGLV4-69 PHBP5SNX17 GSTP1 CLASP1 PLCXD2 FAM159A TMEM41B ZNF655 ST8SIA4 LINC00501 PINX1IFNGR1 VDAC1P1 OARD1 ACTG1P3 RTN4IP1 RP11-355B11.2 RP11-215P8.3 MANBAAKR7A2 ZNF616 SCARB2 TRIT1 LY6E AC092171.4 AC083899.3 SLC16A1RP11-6N17.6 CCDC47 RP11-297B17.3 SCN8A CTC-250I14.3 MOSPD2 MYO1D VAMP3TTC13 ELF3 MOV10 VSTM5 NTMT1 THEM6 ZMYND10 FAM131A CYB561D2 HSD17B6UNC119B SETD3 CPNE5 JAK2 TNFRSF10D SCAI PTCD2 TM2D2 CTD-2528L19.6 EMG1LINC00562 PANX2 FAM71F2 IDH3A GATAD1 UBE2D2 PALD1 MTMR10 RP11-85I17.2RP11-517P14.2 LRRC61 CPNE3 ALKBH4 RP11-667M19.9 MOV10L1 MTFR1RP4-657E11.10 LINC00094 PTGR2 ZBTB11 PINLYP SETMAR CTD-2083E4.5 SETD4RP11-497H17.1 CLK3 PIGW TAC01 RNF130 SLC37A1 SHANK2 C8orf44-SGK3 NOXRED1SSR1 PIGO STX1A LYRM2 FAM227A RP11-151A6.4 RP11-402J7.2 C1orf61 GM2ANDUFAF4 CTD-2308B18.4 TBC1D2 VTI1B UBN2 CCNE2 COG5 CTD-2521M24.5 EXD2HHLA3 CTD-2521M24.4 CFAP206 FBXW11P1 TAZ MALAT1 CTD-2095E4.5 RNASEH2APCDHGA8 RP11-1094M14.11 VDAC1 TBCD IKBKB PTDSS2 CTC-265F19.1RP11-637A17.2 RP1-12G14.7 MRPS25 APOL5 AL136419.6 LRRC23 PLGRKT BZW1P2MRPL37 NOMO2 NCOA1 ZNF551 PIGU HNRNPKP1 IFI44L HSDL2 ISCA2 LCOR TFCP2L1RP11-155G14.5 AC007285.6 SLC2OA2 RPN1 METTL16 RP11-334G22.1RP11-274B21.3 MRPL19 LPIN3 LA16c-358B7.3 ENTPD5 LRRC37A15P DCAF10 DDX60LABHD2 ITSN1 DGAT1 RCN1 SMC1B UBE2R2 AC109826.1 CUL9 RP13-131K19.2SLC31A1 CTC-454I21.3 BDH1 RTN4 OXNAD1 ATP5SL RP13-516M14.4 RP4-635E18.9LSM12P1 TIAF1 MT-CO3 RP11-977G19.10 RDH14 RP13-188A5.1 CD302 SGK3 BBOX1SMTN SPECC1L-ADORA2A RP11-167P11.2 GPM6B LINC01140 DBT CCDC120RP11-117D22.2 VPS39 PAK6 RPL23AP7 SMIM11A ZC3H12D STRA13 RP11-134E15.2C8orf33 NONOP2 COQ6 RPL26L1 RP11-757O6.1 FAM95B1 FAM169A TICRR MRPL21HIATL1 HSD17B7P2 KCTD5 PAM16 CTC-479C5.10 SCAMP2 RP11-182L21.5 SLC24A1RNF44 ZFP36 VPS13C LARGE MAPK8IP2 BID RP3-426I6.6 SLC35A2 RP11-527J8.1RP11-74J13.8 CNR2 TTC39A CREBRF RP11-205M5.3 RP11-231E4.5 BCL2L13 NAA10EMC6 CHST7 C1orf210 TUBG1P ENOSF1 C1orf109 RP11-1H8.5 RP13-392I16.1MTMR9LP MCEE MAP3K13 AC018804.7 ALG2 RP11-70L8.4 ZNF821 PLOD1 DDRGK1RP11-521B24.4 FMO4 PDCD5 CTD-2616J11.10 STAG3L3 ACADS RP11-809N8.2PIK3IP1 NFKBIB BNIP3P11 LMAN1 ZNF785 APOL2 CABP4 RP11-87C12.2 BLCAPTMEM33 KB-1125A3.12 C1orf159 GCNT2 PCDHGA6 IQCC ZNF600 CARS2 TMEM141KLF13 HSF2BP CCNT2 TMEM256-PLSCR3 SLC25A41 GRK6 C2orf47 MRPS2 LAMP2CYP3A5 RP11-104O19.4 AP001055.6 APOBEC3B COCH KSR1 TMX1 SLC25A42 DNAJC18BROX RP11-497G19.1 AC008697.1 SLC25A35 FADD PRPF40A SLC1A5 LIN52 FAM83HGDF9 ERVW-1 EBNA1BP2 CTB-43E15.2 SEC63 FBXL4 ATP2A1-AS1 MTAP USP34 CLN8RP11-247L20.3 C20orf203 ECHDC2 RP11-861A13.3 PROB1 CLIC2 RP11-1148L6.8RP11-467L13.5 RP5-1057I20.2 PANO1 RP11-379K17.2 SEPT7-AS1 SEC22C FHITNCK1-AS1 AC046143.3 HAS3 MLLT10 RP11-45P15.4 CTC-550B14.7 CHEK2AC009133.21 PTRH1 SLC37A4 RTEL1-TNFRSF6B GALT HIBADH TMEM107 MCMDC2DDX11-AS1 TCTA TCL6 SLC27A5 HEXB RP11-381K20.2 TEAD2 LINC01355 NME6 VDRFBRSL1 GRIK5 ZNF599 MON1A TRIM39 RP11-61L23.2 RP11-255C15.3 CLPB INPP5ESTK3 C19orf38 MUC6 GPR176 EMC8 NANS ST20 SCARNA15 SKP1P1 RP11-46D6.1AIF1L P2RY11 DNAJC30 FLJ42969 YIF1B NAA50 GGTA2P BCAS1 SNX21 CD19 ABCB10ZSWIM4 AP000289.6 ANKDD1A HSCB PTPRD CTD-3216D2.5 SEPW1 TTYH1 MMP23BUBA52P6 ABCD4 ZFAND4 GRAPL EIF3K EMB NRG4 RP11-488C13.5 RP11-5C23.1RP11-613D13.5 P2RX1 FAM117B MTCO1P12 C20orf96 RP11-2B6.2 LYL1 C8orf58RP11-324O2.3 RP4-647C14.3 ZNF611 CACNA2D4 PI4KAP2 SKOR1 AC016747.3 APOMRP11-574K11.29 RP11-536K7.3 LMTK2 ABCB9 RP11-497H16.9 IMPG2 RRP8 DERL1NSUN6 FRZB ASMTL-AS1 ASMTL-AS1 SLC25A16 TSPAN33 LRIT3 TET1 RP11-514P8.6C1orf147 TAMM41 GPT RNF138 PWP2 CBWD3 AC004980.7 RP11-77E14.2 CYC1 GRK4AC091729.9 PUM3 RELT ZFAND6 SLFN13 ENTPD3-AS1 SLC39A4 OTP TAGLN LACE1PRR7-AS1 LINC00852 TFR2 ZDHHC12 NAA16 USF3 CTSO NOCT TFAM PLPP6 SPCS2ABHD8 RP11-585P4.5 LAMTOR4 TRMU CTD-2292M16.8 CTD-2544N14.3 AGPAT3RP11-258C19.7 RP11-345P4.7 MINCR CTD-2353F22.1 NRSN2 RAP1B LRRFIP1P1SH3GL1P1 C15orf39 TROVE2 RP11-383F6.1 DNASE1L2 LINC00471 MAP3K8 YJEFN3RAP1GAP2 RP1-59D14.5 PRIM1 DUS4L RP11-426A6.5 TLN2 PUS10 MTIF2 MAML2SH2B1 MFI2 POLR1C BRCC3 RP11-271K11.5 SCO1 GPR82 SMAD6 TMED9 VASPLA16c-321D4.2 IFT81 MT-CO2 RPL24P2 TRMT44 NPM1P24 AC034220.3 RAPH1FAM109B SNRNP48 CTC-471J1.11 LINC00893 CCER2 LAMP3 SDCCAG3 DNAH3 PRR13RP4-734P14.4 HLA-DRA PNPT1 GFM2 BORA RP11-582J16.5 APOL3 ATG14 PLSCR1PRKCSH NAPB PSMA8 TIMMDC1 LRRFIP1 BORCS8-MEF2B RP11-723O4.2 PREPL FUKRDH11 NPEPL1 CD164 RP11-138I18.2 CYGB FASN HEXA-AS1 GFM1 MZF1 TAF6LRP11-676J12.4 CASZ1 NEIL2 ZNF563 NDUFA8 RP11-134G8.5 C12orf77 PIGFCTA-292E10.8 LINC01521 CTB-131B5.5 NUDT14 BAX ALG5 SUB1 CMPK2 AC005083.1CCDC64B AF131216.6 ACO2 LINC00654 PARP12 LA16c-390E6.4 TFB1M NEIL1SWAP70 FAM118A MB21D1 RP1-266L20.9 RP11-291L22.9 TMEM175 MTFP1 RPS6KB2TNFSF9 PARD6B KCNK6 GLCE CDKL1 KCNAB1 AC142528.1 APOBR RP11-563J2.2LINC00643 RP11-685N10.1 NCF1C VAC14-AS1 RP11-415F23.3 MCU SERPINF1DDX11L2 RWDD2B CTD-2369P2.10 GPR68 SUSD3 LRRC37A2 LPCAT3 JAM3CTA-313A17.3 RP11-186N15.3 PHF7 ARMC7 ZNF487 RP11-727F15.12 KRT18P59ZNF18 TAS2R64P MFSD9 SREK1 TFE3 DPH1 RIMKLBP1 STARD7-AS1 RP11-802O23.3MIRLET7BHG LINC00449 CKB RP11-16E18.3 SDCBP2 RP11-700J17.1 CCT6BRP11-21J18.1 SAT1 C17orf58 RP11-770J1.5 RNF121 MIR4435-2HG RARGRP11-538I12.2 RP5-966M1.6 PIGG AFMID ATP5S TTC28 MAP7 B4GALT7 KDF1CTD-2228K2.7 ICAM5 CD63 TTC26 RP5-827C21.4 TM9SF2 N4BP3 SFXN4 CXXC4BNIP3P18 AK1 AC002116.8 ZNF132 NBR2 B4GALT1 GPR157 TECRP1 DHRS11 GALNT6LGR4 LRRC56 LRPPRC AMFR LINC01232 HSPB1 RP4-563E14.1 NDC1 MYLIP CBSLFAM53B EBP SLC4A7 MYO9A RP11-752G15.8 CDCA4P1 CTD-2196E14.6 ZMAT2RP11-10A14.4 IFT88 ARHGAP27 FSTL3 RCN1P2 ITSN2 CTD-3162L10.1 RHOV GHRLOSRP3-323A16.1 AKIP1 LCT RAB12 GLB1L RP11-347C12.3 ZKSCAN2 GCNT1 MLLT3CARKD RP11-677I18.3 RRN3P1 PISD RP1-92O14.3 MTCH2 RP11-1036E20.9 TXNRD2TP53INP2 RP11-503E24.2 NFU1 CTB-92J24.3 CDPF1 FOCAD MXD3 PARVB STPG1TSPAN17 CTD-2240E14.4 LY6G5C ATP6V0D1 CASP10 RP11-674N23.4 RP11-486O12.2RASL10A RCL1 MGAT3-AS1 DDHD2 ARFGEF1 CLCN7 DUSP7 LLNLF-173C4.1 ZNF23ZNF34 CHKB-CPT1B CCR6 SLC38A6 RP11-97O12.6 NEAT1 ERLIN2 PAPLN LRPAP1MTHFR EME1 ACAP3 SDHAF3 RP11-521I2.3 TCP11L2 PI4KAP1 CTD-2396E7.11 ALDOCC19orf24 TP53I13 LINC00926 RP11-4O1.2 SV2B FURIN AIFM2 MRPS15 CDKN2B-AS1CTD-2540L5.6 C1GALT1C1 N6AMT1 TPPP ZNF224 RP3-388M5.9 AD000671.6 CMC4C2orf74 KDELR1 RP11-50E11.2 LINC00216 CD180 CAPG GRIN2D ISG20 AC006014.8CTNND1 RP11-802E16.3 ALKBH6 SLC39A3 C19orf71 MPEG1 RP5-1120P11.1 BMP1SPINT1 PMAIP1 SPNS2 TCF20 RP11-104N10.2 ZNF585B AC099850.1 RP11-278C7.4ALKBH7 SRP19 RP11-326A19.5 PCMTD1 ZNF561 TMEM57 CYP51A1 AC012146.7RP11-640L9.2 RP11-180C16.1 HMGN5 COLEC11 TMEM99 GATB MYBPC1 ALG10 RSG1ALOX12-AS1 AC114271.2 ZNHIT1 RIBC2 MAP6D1 TKT CLIP1 LPAR2 TBC1D3C BCAP31RP11-415F23.2 SDHD LIME1 GALNT12 TMEM181 TFB2M PBX4 IFT22 XXbac- GRAMD1CB461K10.4 RP11-274B21.4 WDFY4 FBXW4P1 SNX16 GPR137B HERC2P3 TTF2 COX18RP11-488L18.10 RP11-490O6.2 LBX2-AS1 SLC25A34 YRDC DSTNP2 ZZZ3RP11-96D1.8 ZBED5-AS1 SSH1 SYNE2 RP11-48B3.4 ANKRD18EP LTB4R2RP11-130L8.3 MNT ZNF619 CCDC183-AS1 ZDHHC18 C9orf43 NDUFAF1 HAUS2 DHCR24GSE1 AQP11 MYO6 AC007880.1 SLC29A1 CRCP XX- WDR97 STARD4-AS1 PQLC3METTL15 C00717C00720L.1 YTHDF3-AS1 CCBL1 RP11-206L10.9 BST2 WASH7PCCDC134 MIB2 RP11-418J17.1 NRBP2 KLHDC1 FBXO44 FADS1 CTA-217C2.2 XXbac-UBE2D4 ACSL3 KCTD21-AS1 TBL2 BPG32J3.22 OXSM HMGCS1 RP11-798G7.8 HMGA1P4PLBD2 CTPS2 RP11-553K8.2 RP11-274B21.2 SLX1A-SULT1A3 CCDC137 SLC25A11SLC35F5 ZNF860 RP11-482G13.1 MFSD4 KIN MRPS7 TPD52L2 NFIA-AS1 TPT1-AS1DBNDD1 MINK1 AGAP5 RP3-368A4.5 DNAJB14 NIPAL3 CXCL16 MMP11 PPM1M DEGS1RP11-97C16.1 XBP1P1 RP6-65G23.3 RNF19B WDR45 ASCC1 MED18 TMEM44-AS1CTD-2186M15.3 RP3-486I3.4 LLNLR-307A6.1 TMEM87B P4HA1 SPON2 CCNG1ZDHHC21 AGGF1P1 KMT2E-AS1 RP11-500C12.1 RP11-386G11.10 HEXIM1 HSP90AB3PKIAA1549L ITM2B NPHP4 ADCK4 NUCB1 ALMS1-IT1 ARHGAP42 POFUT2 MSR1 FAAP24FAM96A CTD-3224K15.3 AKR7L NOP16 COLCA2 IGLL5 RDH13 ZNF32 SEC24B-AS1ZNF573 KIFC2 CSF2RB NSUN5P1 RP11-689B22.2 SLC9A3R1 CAAP1 MSMO1 FLVCR1ACP5 CTD-2012K14.6 GLIDR DLX1 ZNRF3 ARHGAP19-SLIT1 C1QL3 FAHD2CPRP3-468K18.6 NCBP3 DOCK8 C14orf142 LTBP2 INCA1 MXD1 RP11-498C9.3 MED28NABP1 RP11-326C3.12 STYX FAM156A CTA-276F8.1 RP11-73M18.10 AC002310.7ENDOV CTD-2587H24.14 GPR18 SLC35A3 TM2D1 IFNW1 AC002310.12 ADGRE5SLC35E3 RP4-756G23.5 PALM2-AKAP2 MBTPS2 ITGAV GTF2IRD2P1 TPP1 SYTL3RP11-372K14.2 CTC-203F4.2 MRPS18B CTC-487M23.8 MRPL28 RP11-134G8.7 BSGLZTFL1 PIGL NDUFV1 ZMIZ2 ITGA6 AF127936.5 SLC43A3 HRK RDM1 RP11-930P14.2AC127904.2 PRR15L MAN2C1 ERMP1 AC145343.2 PPT2-EGFL8 NPR2 PM20D2Z97634.3 SPDYE6 ATP11A MAGIX C9orf9 ANKRD9 ORAI1 HELLPAR TST HVCN1LRTOMT RP13-638C3.2 HSD17B12 NAGA RP11-888D10.4 SLC22A31 WDR4 EIF4EBP3CTB-89H12.4 CYP4F35P LL0XNC01-116E7.1 GOLM1 ST7L ANKRD20A4 NIFK-AS1 NAAAARRB2 SERPINI1 LRRC20 RP1-197B17.7 RC3H2 HDDC3 TBX10 SLC6A4 PRR34-AS1FBLN7 DISP2 UCP2 AP000432.1 RP11-33O4.2 MBOAT7 ANKRD42 NPC1 CTB-5E10.3DAPK3 RP11-529K1.3 PTPN7 EME2 REEP4 RP11-496H1.1 RPS15AP1 ARRDC3-AS1PLPP5 TSPAN13 TMC6 KLHDC7B OCLM MECP2 RASA4CP NOMO1 FAM212A RP11-23N2.4LDLR PRICKLE4 NCKAP1 RP11-356M20.1 PAN2 TMEM201 CYP51A1P2 DLL1 FAR2P1C11orf53 COPRS RP11-143K11.7 RP11-141O15.1 CTD-2574D22.3 TMEM161A TMBIM1EFEMP2 RP11-576C2.1 CNN2P9 RP11-513M16.8 ICAM2 BBS4 TBKBP1 TXNDC15RP5-1092A3.4 DESI1 ELOVL6 PHPT1 SIRT6 TCEB1P19 RP11-686F15.2 L2HGDHMTND5P11 STK11IP RP11-34P13.13 ELOVL1 RP11-295D4.1 RPL12P25 LINC00339FAM129C IQCE LAPTM5 CRB3 ATP9B SIDT2 DNASE2 CACNA1C-AS1 HSD17B8 PACRGLPHYKPL ANGEL2 CYBA DNAJB6 NCF1 SPATA12 TDRD6 BCLAF1P2 RGS14 IGLV7-43PCDHGA4 DCXR ZFP14 RP11-342I1.2 PIK3R2 L3MBTL4 TMEM161B ZNF613 RAB11FIP4RASA3 TYRO3 IFT140 METTL1 AGER MRI1 MACROD1 D2HGDH ZNF692 BZRAP1 ARID3BRHPN2 MRPL2 NUDT19 PDXDC1 PIEZO1 PARP16 NMI RABL2B FBXL2 RP11-146D12.2FAM86C1 PTCD3 RP11-296I10.3 UBR5-AS1 GRHPR PILRA ZNF440 FBXL22 SNAI3NUDCD2 CXorf38 CD72 STX10 FAM160A2 LRP1 VASH1 APOPT1 GP1BA FLYWCH1 AGR2ANTXR2 SMDT1 PRR33 AC017104.6 RP11-381O7.3 GMPPA NFAT5 RP6-159A1.4RAB40B ARHGEF33 AP006222.2 RP11-127I20.8 FAM76B MAPK12 APOL6 MYO5CFASTKD1 POLR2J3 AC024560.2 MTHFS CKLF WDR66 PELI3 RP1-179N16.3 EHD4TYMSOS CRYBA4 CEP19 RP11-809O17.1 SLC22A18 BET1 LRRC34 SSTR2 ZNF572DNAH17 UNKL NDUFB2-AS1 ARL2 C8orf37 TNRC6C-AS1 ATP6V1C2 BTBD6P1LINC01547 AP000347.2 MROH1 SORBS3 PSMG4 ANKRD23 SATB1 RP11-33B1.4PDCD6IPP1 AC003092.1 TP63 ALG3 CCDC38 RP11-161M6.2 SLC12A9 MIPEPRP11-111F5.5 ZBTB21 ENDOD1 DNAAF3 SCAMP5 IQCG CTD-2538C1.2 ARSG EPB41L1ABCB6 PPCDC TRIM16L HAGHL ABCA1 LRIG2 CYP4V2 MST1L RP11-480A16.1 NDFIP2ANKRD26 LRRC43 DLEU2L RP11-529K1.2 NDST1 JSRP1 GLB1 CCDC30 OXA1LDYX1C1-CCPG1 CABYR RP5-1074L1.4 HOMEZ NR1H3 CBR1 TMEM174 CMTM4 EIF1ADC6orf136 DRC3 ZNF717 RAB11FIP1P1 TBC1D2B PDHX PPP1R21 SLC16A13CTD-3094K11.1 CMB9-22P13.1 SDK1 GOLGA8H RP11-866E20.3 DCAKDRP11-486B10.4 RETSAT AC013461.1 FAM86B3P FAM132B EPB41L4A TLCD1CTA-246H3.12 LRFN1 CAMP REC8 SETD9 NIPSNAP3B FECH FAM21FP ODF3B TTN SDHACTB-147N14.6 CRYZP1 RBM6 LGALS3BP GMDS-AS1 MAN1B1-AS1 ADAM8 RP4-800G7.2C2CD2 CH17-340M24.3 ABHD12 XPNPEP3 CD40 CTA-292E10.6 PIGBOS1 SLC9A7CH507-9B2.3 SPRYD3 INSIG1 GS1-124K5.2 IL9RP3 SMIM10 RP5-967N21.11 CCDC87FAM114A1 IL18BP C17orf104 FKBP11 RP4-758J18.13 TRPV2 DHRS1 PCOLCERP11-517H2.6 ADAP2 CTSA TNK2-AS1 SHPK SPN ACAD11 DLGAP4-AS1 DNAJC17NFYAP1 JMY HMGB3P4 FRMD4A PDSS2 TXNDC11 CYP27B1 AC005944.2 CLN3 PPM1FSPATA33 AC006486.10 RP11-577H5.1 ARHGAP20 RP11-657O9.1 STAG3L5P ANK3SLC2A11 ATP13A1 SACS RP11-613M10.8 C1S MOB3C SH3YL1 AC005532.5RP11-343C2.11 STIM1 ATP6V0A1 ZNF181 CTB-52I2.4 TMEM199 FAM160B2RP11-234B24.4 LAT2 RP11-566K19.6 MX1 SLC25A40 LPCAT1 SCD CHRNA6ATP5J2-PTCD1 S1PR4 CORO1B TK1 TSPAN3 PPP2R5A TCTN2 APOL1 CYTH1 NADK2RP4-591C20.9 GANC RP13-516M14.1 NPTX1 CLCN6 RP1-60O19.2 GNPDA1CTD-3105H18.14 CLDN7 MAG SCARNA12 NIPAL2 LRRC39 CSRP1 DMD HSBP1 TCAF1AC062029.1 SLC25A33 RP11-291B21.2 CTD-2012J19.3 TRIM73 TRIM66 POMT1BBOF1 SHTN1 TXLNB PTGS1 PCBP1-AS1 ACPP SULT1A4 GDPGP1 SLC16A1-AS1RP4-694A7.2 ACER3 OAS3 SLC16A3 LA16c-306A4.2 CRTC1 MEIG1 UBAC2 MLANAANKRD7 ABCC10 SBF2-AS1 BLVRA NOTCH1 ZNF658 RP11-930P14.1 CBS CENPPRP11-848P1.2 NPB MRPL40 EXD3 GUCA1B DHX58 CRTAP PQLC2 FOXH1 EPB41L5NDUFA10 AC006547.8 WI2-87327B8.2 PDXK TARBP1 CGREF1 UAP1L1 LINC01006ZNF660 RP11-309L24.10 CICP27 ESPNL WDR90 RP11-552F3.12 ZNF701 PDDC1KIF9-AS1 TJP2 ADORA2A SENP8 YIPF6 SPNS1 CTD-2026D20.3 ZNF485 ZFP90 ITGB4RP11-513M16.7 FDXR TYMP KLRAP1 RP11-521B24.3 CITF22-1A6.3 SLX1B-SULT1A4BISPR C3orf35 TNFSF15 METAP1D CTD-2083E4.7 B4GAT1 MTFR1L LINC01222 FRG2CWASIR2 STK36 RP11-394B2.5 HMGCL RNF149 RP5-832C2.5 DCTD RP11-797A18.5CNTNAP2 ACOT1 HLA-E RP11-111F5.4 HYAL3 AC005076.5 PCYOX1L LCAT RAB29UMAD1 LIPJ SPTLC2 ADK CRYM-AS1 TSPAN31 FOXRED2 PODXL DND1P1RP5-1142A6.10 IQCH PON2 RGPD5 TSTD3 RP11-574K11.24 RP11-124D2.7 ADAM15ZNF460 RP11-504P24.3 RP11-424G14.1 GALK1 NUMBL ACACA NEK8 HACD4 C16orf86TMEM209 XXbac- POMT2 CAPN12 BPG181B23.7 PTK6 PNPLA4 PRMT5-AS1 BBX EPS8L2VSIG10 PVT1 RND1 ZBTB46 NCS1 CTD-2366F13.1 MANEAL RP11-31H5.3CTC-281F24.5 WWOX PLCG1 SERTAD2 RP11-864I4.1 DUSP3 RP11-574K11.31 PLOD3RP11-20G6.3 OR7E126P MAP7D2 SEC14L1 HDAC11 P4HTM RP11-471B22.3 LINC00877PCBD1 ELFN1-AS1 RASA4B XXbac- NHLRC3 TMC8 B9D1 BPG181M17.6 CAMKK1MKLN1-AS TMCO4 FAM9B RPS6KB1 RP11-362K14.7 LTB4R STAG3L5P-PVRIG2P-AC011747.3 IPCEF1 DARS-AS1 RP11-311C24.1 PILRB DISC1 HNRNPU-AS1AC156455.1 ARMC9 RP11-13P5.1 GPER1 PXN RDH5 LETMD1 RFT1 SMPDL3B PDLIM5WDR73 RP11-53O19.3 PLS1 RNPEP RP11-166O4.6 CTC-425O23.5 CEBPDRP11-228B15.4 PGPEP1 ABHD11 CTD-2587M2.1 Sep-11 GATS SCAMP4 ULK4P1ORAOV1 DNAH8 TRIM65 RP11-932O9.10 IVD CCDC57 CATSPER2 SREBF1 PLLPLINC00467 RASL10B RP4-669L17.10 RP11-98I9.4 CTA-941F9.10 RP11-458F8.4PMEL RILPL2 KIAA1033 NBL1 CD37 H6PD UNC93B1 C17orf99 ZNF789 DEGS2C12orf75 CRIP3 ANKRD10-IT1 AC008079.10 SEPN1 TGIF2-C20orf24 RRAGB UBA7PYCRL THYN1 RP5-965G21.4 CELSR1 AC025171.1 DMPK PILRB SLC45A3 LINC01347SLC29A2 LCMT1-AS2 RPL23AP82 CD27 RP4-583P15.15 CPEB4 ACOT4 TMEM91CASKIN2 ETFB CICP3 TMEM198B RAB36 SLC17A9 MOB1B FARP2 GNGT2 IGHV3-23IGSF6 TM4SF19-AS1 TMOD2 HRSP12 HLA-DMB RLN2 PCSK6 IQUB TRIP6RP11-455F5.3 BLVRB CD6 GCAT NUMB TNK1 GS1-124K5.11 C8orf44 MAP1LC3AZNF705E UPP1 WDTC1 FAM95B1 NCF1B TMEM229B SAPCD1 DPH6 OR7E128P HERC6SCML4 ZNF461 CXXC5 ARHGAP10 PFKM CERS4 DOCK6 GPRASP1 GRAMD4 BFSP2LA16c-329F2.1 RRAS2 MFSD8 RP11-485G7.5 HPDL NDFIP1 CNNM3 ARHGEF16RP11-563N4.1 LAMP1 RP11-395I6.3 CTSZ CMTM3 EPCAM ANKRD30B MARK4 SMARCA2DLEU1_1 TUBB4A RP4-738P15.6 ETHE1 TMC5 PRRG2 MUC4 MND1 MPST LINC00884RP11-92C4.3 RP11-38C17.1 ZNF276 VPREB3 MAN2B1 C1orf228 RP11-96D1.10RP11-362K14.6 TMEM255A ATAD3B HID1 MGAT4A GTF2IP13 NWD1 PLD2 TMEM132ACTC-510F12.4 CCDC171 LRRC14B LSR OLFML2A ELMOD3 TP73-AS1 CLEC17A MED13LZNF579 ZFP3 LINC01588 SPPL2A NFATC3 TLR9 SPIRE2 RP11-77K12.9 NAV2 TNFCBY1 LRP11 RP11-231C14.4 RP11-723O4.9 METTL7A RP11-16E12.1 LINC01128PNPLA2 BATF SLC16A4 RGMB SRC RP11-561B11.2 TNFRSF10B ZDHHC24 PKD1P6 FBF1PROSC FDFT1 ENPP3 USP6 GTF2IP12 FAM86C2P TAS1R1 SLC2A1-AS1 AP5S1 UEVLDNMNAT1 PLA2G12A BRI3 DHRS4 THRA ZNF876P ARHGEF39 CKAP4 CENPBD1 ZBED2LIMA1 NPPA-AS1 CDK10 ACAD8 LACTB2 RP11-547D13.1 RP11-325F22.2 KDSR NMBGRINA RP11-660L16.2 RP11-69E11.4 TSGA10 PARP14 AC024937.6 SLC25A10 SCLYIL21R-AS1 ABHD15 N4BP2L2-IT2 DNASE1L1 RP11-577H5.5 KCNRG TRIM9 FAM49ASLC37A3 ALDH1B1 USP30 SPPL2B SAT2 FAM86JP ITGB1BP2 FBXO6 TMED6 ACCSZNF791 LEKR1 ELK3 SLC16A6P1 RP11-15A1.3 IFIT3 RILP FAM195A JMJD7-PLA2G4BFAM78A AC010524.2 NCF4 LTA EPN2 MAST2 PSAP PSPH POLI BNIP3P41 HEXDCLIMD1-AS1 CTNNBIP1 GRAMD3 RP11-159D12.5 LIMD1 TATDN3 TTC23 EIF3J-AS1ABCA7 CHIT1 RNASET2 ANGPTL6 RP11-439E19.10 SNAI3-AS1 MGST2 EPB41L4A-AS1C19orf54 CD96 PRF1 OSTM1 IL6ST GRM2 PMS2P5 NR3C2 RMDN1 CYB561A3 SCART1SRP14-AS1 LBHD1 TECPR2 NT5DC1 ATP1A1-AS1 C21orf33 RNF213 PECAM1 SLC2A4RGALPK3 GID4 SLC4A4 SCHIP1 RBM26-AS1 LITAF IPP RPS6KA1 RP11-799B12.1 MYO5BMCAT MACROD2 PARD6A MYCL PARD6G UGCG PRKCD RP4-717I23.3 LRRC45 PLXNC1RP11-890B15.3 NR2F6 IFT46 POLD4 OXLD1 AP000347.4 RP11-498C9.15RP11-499P20.2 AC108488.4 LINC00174 LA16c-316G12.2 RP4-714D9.5 TC2NFRMD4B NMT1 CTD-2636A23.2 LGALS9 FBXO4 SSBP4 ANO9 ETS2 ZNF546 CBWD7RP11-545P7.9 RP11-609D21.3 NLRC4 FAM83H-AS1 LINC01585 RP13-20L14.10AGPAT2 PRPF40B CTD-2135D7.2 ILDR1 SUOX FES TSEN54 VPS33B RP11-305E6.4SLC22A5 DDB2 ZNF682 TOR4A MAPK13 ATHL1 DHCR7 FAM150B TMEM106A CLUAP1RP4-635E18.8 GTF2IP20 INPP5J CLYBL RP11-429P3.8 GSTZ1 RP11-12J10.4HIST1H2BN CD59 UBXN8 CDNF SLC48A1 LIPG TNS1 PEX5L AC009403.2 A4GALTRP11-478C19.2 RP11-360L9.7 SARM1 SYT13 IFNG-AS1 POLR3H GIPR IRF5RP11-747H7.3 SPTBN2 GRB7 ACAD10 PLEKHF1 QPRT SLC35G2 XAF1 MSX1 ZNF490RP11-218M22.1 AC073133.2 AACS RP11-768B22.2 HYPK RP11-526I2.5 OCEL1 OMGRP11-274B21.1 FBXO36 PNPLA7 LINC00888 NLRP7 SMIM22 GINS4 RAB19MSH5-SAPCD1 RP11-288H12.3 TESC AC074212.5 CTD-2036P10.3 RASA4 FSTL5DICER1-AS1 CLHC1 DYNC1I1 MUC16 GADD45B SULF2 MSH5 CSNK1E CRYGS LINC00910ESRP2 SIL1 CNNM4 MIR9-3HG STOM AGTRAP SNTA1 MIR210HG MIOX PPM1N CFAP70FAXDC2 SOX8 PPP3CB-AS1 B3GNT7 NAPSB COL9A2 EMP3 CCDC159 AMT LAT SAMD10C2orf15 SLC29A4 ZNF540 METTL20 NEK6 NLRX1 RRBP1 MET ACKR4 ID2RP11-388P9.2 LINC01569 RP11-96D1.11 RP11-473I1.9 SELPLG PARP3 DYNC2LI1RP4-671O14.6 MAP3K7CL ATAD3C CD82 CCDC110 BAZ2B AP001625.6 RAC3 SPHK1APLN KDM4B NAALADL2-AS2 CABLES1 PIGV DLGAP4 C4orf22 SESN1 TNFSF13AC007620.3 USP18 ADAM28 RP4-813D12.3 HMOX1 ZC2HC1C TRIM16 USP3-AS1ALDH6A1 CTC-510F12.6 CD151 PPARA MKS1 ZNF577 RP11-326C3.2 FAM63A CLCN2AHRR FAM26F TMCC1-AS1 BATF2 RREB1 BMS1P4 COL9A3 CCDC78 AGBL2 BANK1LINC01485 TMED7-TICAM2 MARVELD2 LDLRAP1 SLC46A1 FRG2B PCK2 ACY1 KIF26BIFIT1 ZNF780A RP11-449P15.2 SLC16A10 ZNF826P NPIPB6 ITPKB-IT1 SULT1A1FAH C7orf50 PLD3 PARVG ZNF404 SLC23A3 KCNAB3 UBE2O DMXL2 TBC1D24 GLIPR2RP11-809C18.3 TMEM63C PRSS53 GNB4 CH5O7-42P11.8 IFI35 MATN1-AS1 RNF32PLCD3 DAPK2 PTAFR MAPK10 MYRF DEF8 MMAB ITGB1P1 MYO1C GOLGA8R RTBDNFBLN5 DHRS2 ZNF239 HSBP1L1 GOLGA8A IGHD AC007386.4 FAM46C DNAH6 SLC17A7LY96 FADS2 TNFRSF1A SEMA3F-AS1 LYSMD2 SH2D5 DAPL1 MAML3 HNRNPLL C6orf223CAMKV RP11-320N21.1 AGAP10P B3GNTL1 LAIR1 PPP4R4 AC144831.1 C11orf85DDIT4 PLAU FMNL3 LRRC25 AP001057.1 BTBD6 SGPP1 NUDT8 KLHL23 HPGD DUSP16FAM210B AP001058.3 DUSP19 ZNF318 LHPP UBE2Q2P1 TMPRSS15 HFE SH3BP2METRNL LAMTOR5-AS1 UBAP1L IFI30 LINC01104 TMEM143 TBC1D4 CRYBB1 OLMALINCAP001046.5 SAMD7 ENKD1 GRN STAC3 RP11-85B7.2 THEMIS2 PINK1-AS ECE1GPRIN3 ITGA10 PCAT7 IFITM2 KIAA1257 KB-1572G7.2 RP5-965G21.3 RYR1LL22NC03-75H12.2 TCF7L2 SCARB1 BHLHE40 RP11-159D12.2 RP11-1149M10.2ITPRIPL2 DFNA5 ZNF486 SLCO4A1 MYT1 EIF2AK4 ZNF793 SOAT2 NKX6-3 XBP1REPIN1 ADCY7 RBM5-AS1 AC073133.1 GNG7 GPR34 PFKFB4 ITGB1 RAB3DRP11-403A21.1 NCALD FRG2 CYBB ZNF570 EVI2B LAMA5 C16orf54 CTTN MAPK11ADM2 PTK2 C1orf186 IFI27 MMRN1 GALM AC092580.4 CD1A VEGFA PTPRG EYA4ENTPD6 SLC38A5 SLC12A4 GYLTL1B FAM65A IFI44 IGHV1-24 ICAM1 GNG11LINC01021 PAG1 TPM2 ADARB2-AS1 PYGB TRAF3 NINJ1 ANK1 GLRA3 ISYNA1SLC15A3 ERI1 RPP25 LRRC32 SPSB1 MST1R ACSS1 SPOCK3 CCDC85A OXR1 KIAA0930IFITM1 POF1B PRTG NTN1 CSRNP3 MYBPC2 CDKN1A DENND6B FBP1 DIRAS1 IL21RACY3 DENND3 RP11-482H16.1 FNBP1 TTC39C PLXNB2 CD9

TABLE 4 Proteomic Data: Changes in protein expression in OCI-Ly1-S vs.OCI-Ly1-R P21926 P09467 Q96RU3 Q96HD9 Q8N584 Q6K0P9 Q5TEJ8 P09326 O15031Q9Y6K8 Q5EG05 Q96C23 O00182 E9PF32 Q8TF42 O95340-2 Q06278 Q96BY6 Q92542P42892 Q05397-5 P05362 Q9Y228 Q9UKB3 J3KNB4 O43252 Q6ZVF9 J3KQV0 Q6JBY9Q16566 P11216 Q9UPR0 Q6ZTQ3 P11217 Q16880 P04211 Q5H945 Q92974 P06737Q15126 Q16666 P29466 Q8TEA8 O15460 P35610 Q86WJ1 Q92766-2 Q15121 O14862Q5R372 P51858 O60262 P01880-2 Q86VW0 Q9Y2Q0-3 Q86TP1 Q14644 Q9P2K8P55265-2 Q96L92 Q9P2K5 Q14247-2 P55265-4 P15104 Q7Z3K3 Q9BZ72 Q7Z6I6P26447 Q9BTT0 P27540 O95848 O95994 P04839 P61024 Q86X27 Q92733 O60346Q6ZS17-4 Q9BT43 Q9ULH0 O15020 G3V3T2 Q10471 Q6NXT6 P48960 Q5VUA4 Q9Y6Y0P11137 Q14249 Q9C0C9 Q9UNI6 Q15306 P30041 Q8WV74 Q15418-2 Q00534 P16930Q5VT52-3 Q68EM7 Q68EM7-2 Q8N1G0 P07738 P42684 Q9Y3C8 P09601 Q5T5H1Q9P0B6 Q8IZE3 P07355-2 Q05823 Q8NFU3 O75663 Q8WZ42-6 O00584 Q99541Q86TG7 Q5VSY0 Q5SW96 Q86U28 P05556 Q5VT52 Q9H869-9 O14828 Q9BUK6Q14814-4 Q53GL0 P14324-2 Q9BWG4 Q16555 Q8WWI1-3 P48382 Q8NCW5 P29353-3Q96LR5 Q9P2E9 Q9P2E9-2 Q9NPH2 Q7Z7E8 Q9NX05 Q8N6N7 Q8WVV4-1 P52758P06753-3 P06753-6 Q15149 Q8N0V3 P50440 Q9H4A5 P05771-2 P11137-4 Q9UM54Q9UHB6-4 P11047 Q8N6R0 G5E9Q6 Q13568-2 E9PL24 Q9H869 Q9NXJ5 C9JG80Q8IW45 P25445 Q16222 A0PJW8 O15231-6 Q9BXL7 F8W6H6 P30043 P35520-2Q13772 P50440-2 Q8TB37 Q86TG7-2 Q8N9I9-2 P15428 Q96DA2 Q5R372-5 Q5VZK9Q86V21 Q9H2G2-2 B5MCA4 Q9BR61 O75600-2 Q07817 P06753-2 Q07065 Q16822Q00013 Q05655 Q9UKU7 P49189 P14854 Q8N465 P26440 Q9H5K3 Q15052 Q9BUL9Q96QF0 Q9UHB6 Q9HBG7 G3V5T0 P21854 Q9BTZ2 O60504 P07919 Q9Y6H3 Q86X76-2O94964-2 Q9Y6K5 Q8NFQ8 Q96S99 Q8NFF5 Q92535 Q9P215 Q8N4S9 P29350-3Q9Y5K3 Q9NZ45 Q15427 H0YKM0 Q15654 F5GXK8 Q93050-3 Q7L9B9 P51570 Q9UIB8Q9Y6X9 Q53EL6 P29353-6 P25942 F8W726 O43291 Q9UQR0 Q9UKT5 Q6ZMZ3Q96JY6-5 P31641 Q8WXI9 Q9BR76 O95568 O00764 P15121 Q14157-5 M0QXB5Q8WVB3-2 O00159-3 P35080 Q9BZD4 Q9UBF8 Q14157-1 Q8N9M5 P49757 Q9UBQ7Q9Y3D6 P12109 O95466-2 Q8N4P3 P86397 P49585 Q96G23 Q99797 O94985-2Q9BWE0-4 Q7Z2T5 O95236-2 Q14451-3 Q14353 O00560 F5GX28 Q96S90 P82921P19174-2 P51965 Q9BZQ6 Q8WV28-3 Q9NVQ4-2 P19174 Q9BV40 P54819 Q92522Q7Z7K0 Q9HCU8 Q9UBR2 Q7L513-10 Q9UPR3 Q92934 P00813 P52732 Q9H0F7-2Q02818 P09668 Q8NDH3 P23743 Q96DP5 Q96CV9 O43405 Q9BWL3 Q8WV28 Q8TAT5Q15758 P50238 P61925 P11049 P28288 Q5VT06 Q12955 P13674 Q12955-4 Q9BYN0P20592 Q7Z4W1 P0CG34 P31995 Q9UKA9-4 Q9BPX5 Q14766-3 Q8NI37 Q9H0P0-1Q6V0I7 H0UI06 Q9BUI4 Q9Y5B8 Q9HB71 O00115 P34910-2 P14859-2 Q96ER9P10606 Q9H1E5 P32942 P09493-10 O60568 Q8NBN7 O43920 Q4G0N4 P51452P13674-2 Q99519 P35270 Q06481 Q9Y5J9 Q6UXH0 Q9NYJ1 Q14764 Q01415 Q8NF91Q8NFV4 P20273 P62256 B4DNW0 P28799 Q12873-3 Q12873-2 Q765P7 Q5T3I0-3Q9NVI1 P53778 Q9H3D4 Q8IV08 Q58WW2-3 P82912 P53602 E7ESJ3 O94826Q9Y606-2 P30042 Q13946 Q9H223 O15264 Q8IWC1 Q6P996 Q9HBH0 O75506 Q5HYI8Q9Y624 Q96DU3 P19971-2 Q9UBL0-2 Q9H497 Q8ND83 Q9NV96 Q56A73 P16152O95817 Q9BQE5 Q99496 Q6ICG6-2 Q8IUH5 P51553 P11388-4 Q14153 Q86WX3P57086 P00167 P40855 O75844 A6NJ78 Q14894 Q9BXS9 Q9BX95 Q15047 Q6UUV7P04424 Q5JTJ3-3 Q02880-2 Q9Y2Y0 P05129 Q15596 Q969P0 Q9NQT8 Q96MW7P21291 F8WCP2 O14777 O00418 P04844-2 Q9BTK6 Q9H4A4 B5ME60 Q96LB3 P34949P56381 Q9BW92 Q8NDB2 Q8NBM4 Q7Z7K6 Q13761-2 Q8IW35-2 G3V3G9 Q9NR45Q9Y6R0 Q8N6F7-2 Q92540 Q8IWL3 O14921 O14936 Q5T440 P35219 Q9NX61Q9BX40-3 Q15274 O43819 Q9P0P0 P52630 O75976 O94762 O43924 Q96PU8 O14773P16219 Q9P016 Q8TAD7 Q13496 P56377 Q5SQP8 Q13795 Q99653 P98194-3 Q9Y657Q9NSY1 Q8IXU6 Q9NXH8 P40200 Q96RD7 Q9UK58 Q9BWW4 P07339 Q99447 P39880-3A6BM72 Q9UPW6 Q8N2K0 Q13418 Q96L93 Q8IUC4 Q460N5 P04637 Q9BUP3-3 P53365Q96DT6 O95716 Q86UU0 Q9UP95-7 Q9NRZ9 Q96NT1 Q9UH65 Q99574 O15164 Q4U2R6Q9UF12 Q6PIW4 P18850 Q96K30-3 P43307 P82909 Q9Y5P8 F8WCZ3 P35580 Q53ET0P11279 Q6UWP2 P09669 P35580-2 Q9UDY2-3 Q3T8J9 E7EQA9 P67936 P55263-2Q9H6T0 P13284 O96006 P50053 O75648 P17252 Q9Y5V3-2 Q9UDY2 Q9HBI1P17947-2 Q9UNF1 O75116 Q9UQ13 Q9HA82 Q7Z5K2-3 Q8TEM1 P55263 Q14765Q9H7X7 P28290 P47985 Q9NRP2 Q96MH2 Q9BRK5 Q9Y287 Q8TDY2 Q9NRR5 Q9NRD1P04792 P19367 Q6PGN9 Q9BV29-2 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P35611-3 Q5QP82-2 Q13148 Q96QD9 Q96MW5Q01780 Q9H3C7 O15228 J3KNF8 Q9BS34 Q8WVC0 Q9P260 Q96PK6 Q96Q27-2 S4R3H4Q9BVA0 P60842 Q9NPE3 Q8N6S5 Q6NXE6 P46060 E9PBK7 P98164 Q6YHU6 Q9NZL4Q8NE35 Q86Z02 O15084-1 Q9BVV6-3 Q05469 O95835 Q96S66 Q9NRL3-3 Q9HB90P55039 Q9BR77 Q9Y5B0 Q06265-2 Q8NEM7-3 Q9P2J9 Q8WXR4-7 Q15032-3 Q92575P12110 Q15572-6 P78317 Q9H5V7 O00533-2 P55198 O43251-8 Q9UFH2 P06730-2Q96Q05-2 Q9BT92 Q9UI10 P17544-6 B4DY08 Q15648 O60271-4 Q9H0L4 C9JCK5Q9NZC9 O95707 Q9H6R4 O94906 P11831 Q9BUB4 Q6DKK2 J3KPY6 Q01813 Q9H7X3Q2TAL8 Q52LJ0-2 P52298 P68363 Q96DX7 O75934 P04843 Q99543 P27695 Q08334P00491 O95248-4 Q5T0B9 P42331-4 Q8IV38 Q9NVM6 Q969L4 P20338 G5E9V6Q5T2E6 Q06413-5 P55201-2 Q8N139 B5MDU6 E7EQR8 P22670 Q13619 O14976O43683 Q9Y2V2 Q9UIA9 Q99460 Q96N46 Q14964 Q9UKX7 P23396 Q9UH03 Q96SN8Q04446 O76003 Q9Y6C9 P38606 Q15013-3 O43502 P61981 Q92643 P30307Q9UQL6-3 Q9NUL3-7 Q96CB8 Q8WYH8 Q9BY32 Q05048 P06454 Q9BZ29-4 P04035-3P23759 Q9P0J1-2 Q13813 Q96DF8 Q14568 Q15029 Q8WTT2 Q9ULR0-1 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Q14C86-6 Q9UJ78 O95613 O95219 Q12772Q9UBI9 Q13825 O94817 P53992 J3QLM1 Q9HD20 Q9HD20-2 Q15390 Q9P253 P13797Q6ZSZ5 O14908 O95159 P13535 E9PAU2 Q9UDY8 Q9NUU7 Q9UKZ1 O75164 P36915Q8IV04 F8W8D3 Q07352 Q8WVQ1 Q68CZ2 Q96RL1 Q9P2R3-2 B3KS98 Q9NUP9 Q14761P56181 E7EX90 Q9NS86 Q9BRT6 O60308 Q9H6Z4 Q9UM11 P01116-2 O60749 A6NC98P52566 Q9BUL5 P28068 B7WPE2 Q16629 P39748 P50395 Q9P2R6 P13473-3 Q92945O95166 Q9H5V9 Q8N684-3 P07384 Q01844 O43264 Q9BXS6-7 J3KQJ1 Q9Y2X3O75964 Q9HCI7 F5GY05 Q96HU1-2 Q5F1R6-3 Q8IVH8 O60237 P45974-2 Q9BV73Q86Y07 Q6P5Z2 O60337 Q96EP0 Q9Y5P4-3 Q05519 Q7Z591 P31946 P31946-2Q7L273 Q9BWS9 Q8NFZ0-2 P49915 H3BRJ5 Q9Y4E5-4 C9JEH3 O75330-3 Q15631Q9NS73 Q8NEK5-2 O15382 Q96DR4 P51648-2 Q9BTE6 P63146 P41182 Q9H0K6Q96PE3 P08243 O95433 Q12788 Q86X55 P14550 Q96AX1 Q9HC38-2 Q2QGD7O14686-3 Q8N4S0 P60900 Q9Y217 Q6ZSR9 J3KMZ7 Q9H1A3 P29374 Q9Y2W2 Q587I9Q9NQW1 Q16204 Q8NFW8 Q9Y4F3 O75787 P49427 Q9UHX1-5 E9PES4 Q9H7L9 P33240O00151 Q15008 Q9Y6I3 Q9NW68 Q12834 Q8NEL9 P20671 P0C0S8 Q93077 Q13867P42331 Q9HC10 O75935 P32004 Q969V5 X6RLX0 Q8TB96 Q15431 Q9HCE7 Q8TEQ6Q5QP82 P23368 Q969F1 P27361 Q96MF7 P20929-2 P26641 O60232 P01111 Q9Y2U9K7ERU7 Q9Y3F4 O60925 Q9H5H4 Q9P2G1 Q9NQ29 Q9NV88 Q86W92 Q6P1M9 Q3YEC7Q9BXS6 Q6QNY0 Q9UHL4 Q9Y6X3 Q6AI39 Q8IWV8 O60427 P13489 Q9BS16 P07902Q9NSD9 P27694 Q8IY95 O75208 O95232 Q9BVI4 Q14847 Q86TX2 Q13748 Q96AG4P04233-2 O75534 Q8NBF6 G8JLB6 M0QY62 P35998 O43237 O75446 Q92888-3Q8N9N2-2 Q9BXS6-6 P25787 Q13610 Q9H944 Q9H116 Q16526 P27144 P13994Q9UBE0 Q5VZF2 Q9NVU0 Q96IK1 Q9NS56 Q5SQI0 Q9NNW7 Q96FW1 Q86VE9-4 Q9Y3D2Q96EP5 J3KNI1 Q92615 P36543 Q15973 Q92804 Q6QNY1 Q3SXM0 Q5T9S5 O15525Q6P4A7 P41223 Q5RKV6 Q6ZUJ8 Q9NVF7 Q6PJT7-3 P01112 Q9Y6G5 Q9C0B2 O00458O43324 Q9Y320 Q66K14 Q16563-2 Q6P3S6 Q96DY2 A2BF26 P61769 Q7Z7A1 Q5VWJ9P17812 P61313 O95793 Q56NI9 Q5T8I9 Q6B0I6 Q92738 P62875 P52434 A2AJT9P37108 O95985 Q9H0J9 Q15067-2 Q00537-2 Q9UKV8 Q9UBI4 Q96BZ9-3 Q8WUX1Q14563 C9JCC6 Q9BUW7 Q9H4H8 P50548 Q9C0D2-3 Q5T6J7-2 P17031 Q9UKV3-3Q15003 Q9UJV9 Q15102 O75151 Q9NSI6-2 Q9GZS3 Q9Y3B2 Q12965 Q9H1U9 Q03001Q86YT6 Q12851 P45954 Q16342 Q6P2E9 Q6NXR4 E7EWN3 Q13751 Q8N653 Q8N5C7Q15493 Q8NFU7 Q7Z340 Q7Z624 O60513 Q8WUJ0 Q9NZB2-6 Q8WUZ0-2 P13796Q16637 Q86YC2 Q9Y3S1 Q15019-2 J3KQ48 Q99487 Q9NW38-2 Q5W0U4 O60869Q16514 Q9BQE3 Q96CS4 Q9UET6 Q86U06 O75306 P31146 Q8NEY8-3 Q6PJG6 Q8TEA1Q9NUG6 Q9UHG3 Q86UA6-8 P02788 G5E9N2 P00505 P00441 Q9UL59 Q96JF6 Q52M93P99999 Q9HAN9 P01024 P01023 P20742 P19823 P17900 P51508 P07996 P02774-3Q16854 P23142 P0C0L5 P98182 Q15063 Q13424 Q9BSG1 Q9UIE0 O95363 Q6PF04Q06033 P02751-15 P04733 Q5TEC3 Q9BSK2 P08697 P47989 Q86VK4-5 B7ZKJ8Q9BU19 Q92902 Q8IVS8 O15239 Q86SE9 O75298 Q8NE62 P54284 Q9HDC5 P51884A8MX12 P36955 Q9Y6T7 Q9UPV9 Q8WUY8 Q6ICH7 Q5VYJ5 P50454 Q9NWT8 O94941Q16772 P0CG23 Q15406 Q6ZNH5 Q8TCU6 Q12766 Q8N7B6 Q9H0V9-2 Q9NQV7 J3KTH2P01579 Q13609 P08603 P01008 Q9H6S1 P43652 Q96T25 O95445 Q5JUQ0 Q6ZSB9E9PIM0 Q494V2-2 Q86UK5 Q12923-4 Q13563 P08151

Use of Signature Genes

The invention provides BCL-2 related gene signatures for use in avariety of diagnostic and/or therapeutic indications. For example, theinvention provides BCL-2 related signatures that are useful in a varietyof diagnostic and/or therapeutic indications. In certain embodiments,the invention provides for signatures of BCL-2 inhibitor resistance.

“Signatures” in the context of the present invention encompasses,without limitation nucleic acids, together with their polymorphisms,mutations, variants, modifications, subunits, fragments, and otheranalytes or sample-derived measures.

Exemplary signatures are shown in Tables 1, 2, 3 and 4 and arecollectively referred to herein as, inter alia, “BCL-2 associatedgenes,” “BCL-2 inhibitor resistance associated genes,” “BCL-2-associatednucleic acids,” “signature genes,” or “signature nucleic acids.”

These signatures are useful in methods of diagnosing, prognosing and/orstaging a treatment or response in a subject by detecting a first levelof expression, activity and/or function of one or more signature genesor one or more products of one or more signature genes selected fromthose listed in Tables 1, 2, 3 and 4 and comparing the detected level toa control of level of signature gene or gene product expression,activity and/or function, wherein a difference in the detected level andthe control level indicates that the presence of a response in thesubject.

These signatures are useful in methods of monitoring an treatment orresponse in a subject by detecting a level of expression, activityand/or function of one or more signature genes or one or more productsof one or more signature genes selected from those listed in Tables 1,2, 3 and 4 at a first time point, detecting a level of expression,activity and/or function of one or more signature genes or one or moreproducts of one or more signature genes selected from those listed inTables 1, 2, 3 and 4 at a second time point, and comparing the firstdetected level of expression, activity and/or function with the seconddetected level of expression, activity and/or function, wherein a changein the first and second detected levels indicates an effect of thetreatment of change in the response in the subject.

The terms “diagnosis” and “monitoring” are commonplace andwell-understood in medical practice. By means of further explanation andwithout limitation the term “diagnosis” generally refers to the processor act of recognizing, deciding on or concluding on a disease orcondition in a subject on the basis of symptoms and signs and/or fromresults of various diagnostic procedures (such as, for example, fromknowing the presence, absence and/or quantity of one or more biomarkerscharacteristic of the diagnosed disease or condition). The term“monitoring” generally refers to the follow-up of a disease or acondition in a subject for any changes which may occur over time.

The terms “prognosing” or “prognosis” generally refer to an anticipationon the progression of a disease or condition and the prospect (e.g., theprobability, duration, and/or extent) of recovery. A good prognosis ofthe diseases or conditions taught herein may generally encompassanticipation of a satisfactory partial or complete recovery from thediseases or conditions, preferably within an acceptable time period. Agood prognosis of such may more commonly encompass anticipation of notfurther worsening or aggravating of such, preferably within a given timeperiod. A poor prognosis of the diseases or conditions as taught hereinmay generally encompass anticipation of a substandard recovery and/orunsatisfactorily slow recovery, or to substantially no recovery or evenfurther worsening of such.

These signatures are useful in methods of identifying patientpopulations at risk or suffering from a BCL-2 or BCL-2 family drivendisease or disorder based on a detected level of expression, activityand/or function of one or more signature genes or one or more productsof one or more signature genes selected from those listed in Tables 1,2, 3 and 4. These signatures are also useful in monitoring subjectsundergoing treatments and therapies to determine efficaciousness of thetreatment or therapy. These signatures are also useful in monitoringsubjects undergoing treatments and therapies for aberrant BCL-2 or BCL-2family driven disease(s) or disorder(s) to determine whether the patientis responsive to the treatment or therapy. These signatures are alsouseful for selecting or modifying therapies and treatments that would beefficacious in treating, delaying the progression of or otherwiseameliorating a symptom of a BCL-2 or BCL-2 family driven disease ordisorder. The signatures provided herein are useful for selecting agroup of patients at a specific state of a disease with accuracy thatfacilitates selection of treatments.

In certain embodiments, the signature genes are used to determine BCL-2responsive pathways. For example, groups of signature genes may indicatepathways that are differentially active or inactive in BCL-2 inhibitorresistant subjects. In contrast to gene-level analysis, pathway-levelgeneset enrichment analysis (GSEA) based on RNA expression or proteinexpression can be used to reveal significantly enriched pathways. Theanalysis of data for the BCL-2 responsive genes revealed 35significantly enriched pathways (Table 5). Consistent with pathway-levelresults from Applicants' gain- and loss-of-function screens (Tables 1and 2), positively regulated pathways included lymphoid differentiationand chromatin maintenance, while top negatively regulated pathwaysrelated to metabolism and the endoplasmic reticulum. In addition, asobserved in Applicants' functional genomics screens, the mostcoordinately upregulated transcripts and proteins (Tables 3 and 4)originated from genes critical to cellular metabolism (AOX1, GLUL,PAPSS1, GATM, TSTD1, GALM, FBP1). The other upregulatedtranscripts/proteins highlighted other mechanisms of interest, includingcell cycle regulation (CDK6, CDKN1A [encoding p21], TT39C), B-cellbiology (DOCK10) as well as autophagy (DENND3, OPTN) and reactive oxygenspecies generation (CYBB). In certain embodiments, pathway specificbiomarkers may be used in methods of diagnosing, prognosing and/orstaging a treatment or response in a subject. For example, detectingmetabolites or intermediates related to OXPHOS or glycolysis in asubject tumor sample can be used in monitoring, diagnosing, prognosingand/or staging a treatment or response. The pathways may indicateappropriate treatments that modulate such pathways. Screening for agentscapable of modulating pathways are described further herein.

TABLE 5 GENESET ENRICHMENT ANALYSIS NAME SIZE NES NOM p-val FDR q-valPOSITIVELY REGULATED PATHWAYS PCG PROTEIN COMPLEX 43 1.9235198 0.00.014543598 STEROID HYDROXYLASE ACTIVITY 24 1.8683462 0.0 0.05157862 TCELL DIFFERENTIATION 117 1.8198463 0.0 0.120191924 LYMPHOCYTEDIFFERENTIATION 193 1.8131264 0.0 0.10498436 POSITIVE REGULATION OFSTRIATED 45 1.804444 0.0 0.1016172 MUSCLE CELL DIFFERENTIATION DNAPACKAGING COMPLEX 100 1.7810507 0.0 0.14139923 REGULATION OF SYNAPTICTRANSMISSION GABAERGIC 24 1.7761554 0.001980198 0.13557017 VENTRALSPINAL CORD DEVELOPMENT 32 1.7603424 0.0 0.16121376 SYMPATHETIC NERVOUSSYSTEM DEVELOPMENT 17 1.7601466 0.0 0.14384659 BILE ACID TRANSMEMBRANETRANSPORTER ACTIVITY 15 1.7552881 0.0 0.14266519POSITIVE_REGULATION_OF_HEART_RATE 19 1.751453 0.008032128 0.14007458PALATE_DEVELOPMENT 75 1.7337528 0.0 0.18172325 POSITIVE REGULATION OFSYNAPTIC 16 1.7321408 0.0 0.17230986 TRANSMISSION GLUTAMATERGICPOSITIVE_REGULATION_OF_DNA_REPLICATION 79 1.7309617 0.0 0.16379696RETINAL_GANGLION_CELL_AXON_GUIDANCE 15 1.7172953 0.0018552876 0.19632848CHROMATIN_ASSEMBLY_OR_DISASSEMBLY 160 1.7099936 0.0 0.20630613SOMATIC_STEM_CELL_POPULATION_MAINTENANCE 58 1.709694 0.0 0.19516784RESPONSE_TO_THYROID_HORMONE 20 1.7076536 0.0 0.18985793DORSAL_VENTRAL_PATTERN_FORMATION 68 1.7060037 0.0 0.18497069POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY 23 1.7044773 0.005893910.18069062 REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION 26 1.69938060.0041067763 0.18644898 SPINAL_CORD_DEVELOPMENT 77 1.6937388 0.00.1966693 POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION 31 1.68706110.0020618557 0.20881929 NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT 261.6839164 0.0 0.20982039 CHEMOREPELLENT_ACTIVITY 22 1.67880610.004282655 0.22063723 PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION 2111.6782055 0.0 0.21470988 WNT_PROTEIN_BINDING 27 1.6703441 0.0040485830.23074459 REGULATION_OF_INTERLEUKIN_2_PRODUCTION 48 1.66734840.0018832391 0.2332876 EPHRIN_RECEPTOR_SIGNALING_PATHWAY 79 1.666566 0.00.22796643 SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION 23 1.66340610.015414258 0.23156029 PHOSPHATIDYLCHOLINE_BINDING 19 1.65882170.0020533882 0.23783724 HISTONE_BINDING 166 1.6528594 0.0 0.24368814DORSAL_VENTRAL_AXIS_SPECIFICATION 20 1.6481357 0.0040650405 0.24738972THYMOCYTE_AGGREGATION 45 1.6458653 0.0055658626 0.24832642LEUKOCYTE_CELL_CELL_ADHESION 237 1.6438192 0.0 0.24956845 NEGATIVELYREGULATED PATHWAYS MANNOSE_BINDING 17 −1.7186749 0.0 0.7195255LIPID_DIGESTION 15 −1.7161826 0.0 0.5036717 MODIFIED AMINO ACIDTRANSMEMBRANE 15 −1.6844256 0.0 0.6472107 TRANSPORTER ACTIVITYRECEPTOR_AGONIST_ACTIVITY 16 −1.6562554 0.0 0.8093361 DIGESTION 105−1.6091654 0.0 0.9079605 INTRINSIC COMPONENT OF ENDOPLASMIC 117−1.5847611 0.0 0.8077308 RETICULUM MEMBRANE OXIDOREDUCTASE ACTIVITYACTING ON THE CH_OH 102 −1.5729672 0.0 0.82296866 GROUP OF DONORS NAD ORNADP AS ACCEPTOR

Detection of Biomarkers

In certain embodiments, a BCL-2 inhibitor resistance signature isdetected in a subject in need thereof. In certain embodiments, the genesselected from the group consisting of: PMAIP1, BAX, NFKBIA, IKZF5, BAK1,ID3, EP300, ZEB2, NFIA, BCL2L11 and OTUD5; or FNBP1, CD9, PLXNB2, TTC39Cand DENND3; or XBP1, CYBB, PAG1 and DIRAS1; or CD9, PLXNB2, TTC39C,DENND3, ICAM1, GNG7, ID2, FNBP1, FBP1, ACY3, CDKN1A, GALM, PTK2 andCYBB, are downregulated as compared to a reference value. In certainembodiments, the genes selected from the group consisting of: BCL2L1,BCL2L2, BCL2, MCL1, SRPX, RNF26, HSPB9, OR1S2, ADIPOQ, PIGF, CSGALNACT1,OTUD6A, SLC25A3, PRKAR2B, DNM2, SPHAR, APOBEC3C, RPL17, INMT, THADA,SBNO2, PRKAA2, BRMS1L, TRNAU1AP, CNNM3, ADAM33, PRKD2, FCHSD2,LOC399886, BABAM1, C1orf146, LMAN2L, ZNF460, TEX2, YRDC, ARHGAP11A,SPEG, FBXO9, USP54, SLC22A6, RPS4Y1, FAM71C, SH3BGRL2, HCRTR1, BST1,PH1F10, UCKL1, ATG5, RPS15A, CDC20B, PPIE, TUT1, RPL36, HSD11B1L,MTERF4, PTS, S1PR4, HJURP, HMMR, BOLA2, DNASE1L1, OSGEP, TMBIM4, BTNL3,CHRM3, FBX015, KLK8, ASPN, STYK1 and SRSF6; or SYT11, PARM1, ROBO2,CD48, FCRL1 and MCL1; or PLCL2, KCNA3, TNFRSF21, CYP2U1, TRAM2 andRAPGEF5; or TSTD1, DNAJC12, TRAF3IP3, OPTN, DOCK10, PYHINI, CD48, P4HA2,PLCL2, AOX1, CDK6, GATM, GLUL, PAPSS1, MCL1 and GATM, are upregulated ascompared to a reference value. In certain embodiments, if a BCL-2inhibitor resistance signature is detected, the subject may require atreatment that includes a combination therapy described herein or atherapy according to any embodiment herein that includes more than aBCL-2 inhibitor or an alternative to a BCL-2 inhibitor.

The signatures herein provide biomarkers (e.g., phenotype specific orcell type) for the identification, diagnosis, prognosis and manipulationof cell properties, for use in a variety of diagnostic and/ortherapeutic indications. Biomarkers in the context of the presentinvention encompasses, without limitation nucleic acids, proteins,reaction products, and metabolites, together with their polymorphisms,mutations, variants, modifications, subunits, fragments, and otheranalytes or sample-derived measures. In certain embodiments, biomarkersinclude the signature genes or signature gene products, and/or cells asdescribed herein.

Biomarkers are useful in methods of diagnosing, prognosing and/orstaging a cellular response, such as an apoptotic response, in a subjectby detecting a first level of expression, activity and/or function ofone or more biomarkers and comparing the detected level to a controllevel wherein a difference in the detected level and the control levelindicates that the presence of an immune response in the subject.

The biomarkers of the present invention are useful in methods ofidentifying patient populations at risk or suffering from resistance tocancer treatments based on a detected level of expression, activityand/or function of one or more biomarkers. These biomarkers are alsouseful in monitoring subjects undergoing treatments and therapies forsuitable or aberrant response(s) to determine efficaciousness of thetreatment or therapy and for selecting or modifying therapies andtreatments that would be efficacious in treating, delaying theprogression of or otherwise ameliorating a symptom. The biomarkersprovided herein are useful for selecting a group of patients at aspecific state of a disease with accuracy that facilitates selection oftreatments.

The biomarkers may be used to predict disease progression. The terms“predicting” or “prediction” generally refer to an advance declaration,indication or foretelling of a disease or condition in a subject not(yet) having said disease or condition. For example, a prediction of adisease or condition in a subject may indicate a probability, chance orrisk that the subject will develop said disease or condition, forexample within a certain time period or by a certain age. Saidprobability, chance or risk may be indicated inter alia as an absolutevalue, range or statistics, or may be indicated relative to a suitablecontrol subject or subject population (such as, e.g., relative to ageneral, normal or healthy subject or subject population). Hence, theprobability, chance or risk that a subject will develop a disease orcondition may be advantageously indicated as increased or decreased, oras fold-increased or fold-decreased relative to a suitable controlsubject or subject population. As used herein, the term “prediction” ofthe conditions or diseases as taught herein in a subject may alsoparticularly mean that the subject has a ‘positive’ prediction of such,i.e., that the subject is at risk of having such (e.g., the risk issignificantly increased vis-à-vis a control subject or subjectpopulation). The term “prediction of no” diseases or conditions astaught herein as described herein in a subject may particularly meanthat the subject has a ‘negative’ prediction of such, i.e., that thesubject's risk of having such is not significantly increased vis-à-vis acontrol subject or subject population.

Hence, the methods may rely on comparing the quantity of biomarkers, orgene or gene product signatures measured in samples from patients withreference values, wherein said reference values represent knownpredictions, diagnoses and/or prognoses of diseases or conditions astaught herein.

For example, distinct reference values may represent the prediction of arisk (e.g., an abnormally elevated risk) of having a given disease orcondition as taught herein vs. the prediction of no or normal risk ofhaving said disease or condition. In another example, distinct referencevalues may represent predictions of differing degrees of risk of havingsuch disease or condition.

In a further example, distinct reference values can represent thediagnosis of a given disease or condition as taught herein vs. thediagnosis of no such disease or condition (such as, e.g., the diagnosisof healthy, or recovered from said disease or condition, etc.). Inanother example, distinct reference values may represent the diagnosisof such disease or condition of varying severity.

In yet another example, distinct reference values may represent a goodprognosis for a given disease or condition as taught herein vs. a poorprognosis for said disease or condition. In a further example, distinctreference values may represent varyingly favourable or unfavourableprognoses for such disease or condition.

Such comparison may generally include any means to determine thepresence or absence of at least one difference and optionally of thesize of such difference between values being compared. A comparison mayinclude a visual inspection, an arithmetical or statistical comparisonof measurements. Such statistical comparisons include, but are notlimited to, applying a rule.

Reference values may be established according to known procedurespreviously employed for other cell populations, biomarkers and gene orgene product signatures. For example, a reference value may beestablished in an individual or a population of individualscharacterized by a particular diagnosis, prediction and/or prognosis ofsaid disease or condition (i.e., for whom said diagnosis, predictionand/or prognosis of the disease or condition holds true). Suchpopulation may comprise without limitation 2 or more, 10 or more, 100 ormore, or even several hundred or more individuals.

A “deviation” of a first value from a second value may generallyencompass any direction (e.g., increase: first value > second value; ordecrease: first value <second value) and any extent of alteration.

For example, a deviation may encompass a decrease in a first value by,without limitation, at least about 10% (about 0.9-fold or less), or byat least about 20% (about 0.8-fold or less), or by at least about 30%(about 0.7-fold or less), or by at least about 40% (about 0.6-fold orless), or by at least about 50% (about 0.5-fold or less), or by at leastabout 60% (about 0.4-fold or less), or by at least about 70% (about0.3-fold or less), or by at least about 80% (about 0.2-fold or less), orby at least about 90% (about 0.1-fold or less), relative to a secondvalue with which a comparison is being made.

For example, a deviation may encompass an increase of a first value by,without limitation, at least about 10% (about 1.1-fold or more), or byat least about 20% (about 1.2-fold or more), or by at least about 30%(about 1.3-fold or more), or by at least about 40% (about 1.4-fold ormore), or by at least about 50% (about 1.5-fold or more), or by at leastabout 60% (about 1.6-fold or more), or by at least about 70% (about1.7-fold or more), or by at least about 80% (about 1.8-fold or more), orby at least about 90% (about 1.9-fold or more), or by at least about100% (about 2-fold or more), or by at least about 150% (about 2.5-foldor more), or by at least about 200% (about 3-fold or more), or by atleast about 500% (about 6-fold or more), or by at least about 700%(about 8-fold or more), or like, relative to a second value with which acomparison is being made.

Preferably, a deviation may refer to a statistically significantobserved alteration. For example, a deviation may refer to an observedalteration which falls outside of error margins of reference values in agiven population (as expressed, for example, by standard deviation orstandard error, or by a predetermined multiple thereof, e.g., ±1×SD or±2×SD or ±3×SD, or ±1×SE or ±2×SE or ±3×SE). Deviation may also refer toa value falling outside of a reference range defined by values in agiven population (for example, outside of a range which comprises 40%,50%, ≥60%, ≥70%, ≥75% or 80% or 85% or 90% or 95% or even 100% of valuesin said population).

In a further embodiment, a deviation may be concluded if an observedalteration is beyond a given threshold or cut-off. Such threshold orcut-off may be selected as generally known in the art to provide for achosen sensitivity and/or specificity of the prediction methods, e.g.,sensitivity and/or specificity of at least 50%, or at least 60%, or atleast 70%, or at least 80%, or at least 85%, or at least 90%, or atleast 95%.

For example, receiver-operating characteristic (ROC) curve analysis canbe used to select an optimal cut-off value of the quantity of a givenimmune cell population, biomarker or gene or gene product signatures,for clinical use of the present diagnostic tests, based on acceptablesensitivity and specificity, or related performance measures which arewell-known per se, such as positive predictive value (PPV), negativepredictive value (NPV), positive likelihood ratio (LR+), negativelikelihood ratio (LR−), Youden index, or similar.

In one embodiment, the signature genes, biomarkers, and/or cells may bedetected or isolated by immunofluorescence, immunohistochemistry (IHC),fluorescence activated cell sorting (FACS), mass spectrometry (MS), masscytometry (CyTOF), RNA-seq, single cell RNA-seq, quantitative RT-PCR,single cell qPCR, FISH, RNA-FISH, MERFISH (multiplex (in situ) RNA FISH)and/or by in situ hybridization. Other methods including absorbanceassays and colorimetric assays are known in the art and may be usedherein. Detection may comprise primers and/or probes or fluorescentlybar-coded oligonucleotide probes for hybridization to RNA (see e.g.,Geiss G K, et al., Direct multiplexed measurement of gene expressionwith color-coded probe pairs. Nat Biotechnol. 2008 March; 26(3):317-25).

MS Methods

Biomarker detection may also be evaluated using mass spectrometrymethods. A variety of configurations of mass spectrometers can be usedto detect biomarker values. Several types of mass spectrometers areavailable or can be produced with various configurations. In general, amass spectrometer has the following major components: a sample inlet, anion source, a mass analyzer, a detector, a vacuum system, andinstrument-control system, and a data system. Difference in the sampleinlet, ion source, and mass analyzer generally define the type ofinstrument and its capabilities. For example, an inlet can be acapillary-column liquid chromatography source or can be a direct probeor stage such as used in matrix-assisted laser desorption. Common ionsources are, for example, electrospray, including nanospray andmicrospray or matrix-assisted laser desorption. Common mass analyzersinclude a quadrupole mass filter, ion trap mass analyzer andtime-of-flight mass analyzer. Additional mass spectrometry methods arewell known in the art (see Burlingame et al., Anal. Chem. 70:647 R-716R(1998); Kinter and Sherman, New York (2000)).

Protein biomarkers and biomarker values can be detected and measured byany of the following: electrospray ionization mass spectrometry(ESI-MS), ESI-MS/MS, ESI-MS/(MS)n, matrix-assisted laser desorptionionization time-of-flight mass spectrometry (MALDI-TOF-MS),surface-enhanced laser desorption/ionization time-of-flight massspectrometry (SELDI-TOF-MS), desorption/ionization on silicon (DIOS),secondary ion mass spectrometry (SIMS), quadrupole time-of-flight(Q-TOF), tandem time-of-flight (TOF/TOF) technology, called ultraflexIII TOF/TOF, atmospheric pressure chemical ionization mass spectrometry(APCI-MS), APCI-MS/MS, APCI-(MS).sup.N, atmospheric pressurephotoionization mass spectrometry (APPI-MS), APPI-MS/MS, andAPPI-(MS).sup.N, quadrupole mass spectrometry, Fourier transform massspectrometry (FTMS), quantitative mass spectrometry, and ion trap massspectrometry.

Sample preparation strategies are used to label and enrich samplesbefore mass spectroscopic characterization of protein biomarkers anddetermination biomarker values. Labeling methods include but are notlimited to isobaric tag for relative and absolute quantitation (iTRAQ)and stable isotope labeling with amino acids in cell culture (SILAC).Capture reagents used to selectively enrich samples for candidatebiomarker proteins prior to mass spectroscopic analysis include but arenot limited to aptamers, antibodies, nucleic acid probes, chimeras,small molecules, an F(ab′)₂ fragment, a single chain antibody fragment,an Fv fragment, a single chain Fv fragment, a nucleic acid, a lectin, aligand-binding receptor, affybodies, nanobodies, ankyrins, domainantibodies, alternative antibody scaffolds (e.g. diabodies etc)imprinted polymers, avimers, peptidomimetics, peptoids, peptide nucleicacids, threose nucleic acid, a hormone receptor, a cytokine receptor,and synthetic receptors, and modifications and fragments of these.

Immunoassays

Immunoassay methods are based on the reaction of an antibody to itscorresponding target or analyte and can detect the analyte in a sampledepending on the specific assay format. To improve specificity andsensitivity of an assay method based on immunoreactivity, monoclonalantibodies are often used because of their specific epitope recognition.Polyclonal antibodies have also been successfully used in variousimmunoassays because of their increased affinity for the target ascompared to monoclonal antibodies Immunoassays have been designed foruse with a wide range of biological sample matrices Immunoassay formatshave been designed to provide qualitative, semi-quantitative, andquantitative results.

Quantitative results may be generated through the use of a standardcurve created with known concentrations of the specific analyte to bedetected. The response or signal from an unknown sample is plotted ontothe standard curve, and a quantity or value corresponding to the targetin the unknown sample is established.

Numerous immunoassay formats have been designed. ELISA or EIA can bequantitative for the detection of an analyte/biomarker. This methodrelies on attachment of a label to either the analyte or the antibodyand the label component includes, either directly or indirectly, anenzyme. ELISA tests may be formatted for direct, indirect, competitive,or sandwich detection of the analyte. Other methods rely on labels suchas, for example, radioisotopes (I¹²⁵) or fluorescence. Additionaltechniques include, for example, agglutination, nephelometry,turbidimetry, Western blot, immunoprecipitation, immunocytochemistry,immunohistochemistry, flow cytometry, Luminex assay, and others (seeImmunoAssay: A Practical Guide, edited by Brian Law, published by Taylor& Francis, Ltd., 2005 edition).

Exemplary assay formats include enzyme-linked immunosorbent assay(ELISA), radioimmunoassay, fluorescent, chemiluminescence, andfluorescence resonance energy transfer (FRET) or time resolved-FRET(TR-FRET) immunoassays. Examples of procedures for detecting biomarkersinclude biomarker immunoprecipitation followed by quantitative methodsthat allow size and peptide level discrimination, such as gelelectrophoresis, capillary electrophoresis, planarelectrochromatography, and the like.

Methods of detecting and/or quantifying a detectable label or signalgenerating material depend on the nature of the label. The products ofreactions catalyzed by appropriate enzymes (where the detectable labelis an enzyme; see above) can be, without limitation, fluorescent,luminescent, or radioactive or they may absorb visible or ultravioletlight. Examples of detectors suitable for detecting such detectablelabels include, without limitation, x-ray film, radioactivity counters,scintillation counters, spectrophotometers, colorimeters, fluorometers,luminometers, and densitometers.

Any of the methods for detection can be performed in any format thatallows for any suitable preparation, processing, and analysis of thereactions. This can be, for example, in multi-well assay plates (e.g.,96 wells or 384 wells) or using any suitable array or microarray. Stocksolutions for various agents can be made manually or robotically, andall subsequent pipetting, diluting, mixing, distribution, washing,incubating, sample readout, data collection and analysis can be donerobotically using commercially available analysis software, robotics,and detection instrumentation capable of detecting a detectable label.

Hybridization Assays

Such applications are hybridization assays in which a nucleic acid thatdisplays “probe” nucleic acids for each of the genes to beassayed/profiled in the profile to be generated is employed. In theseassays, a sample of target nucleic acids is first prepared from theinitial nucleic acid sample being assayed, where preparation may includelabeling of the target nucleic acids with a label, e.g., a member of asignal producing system. Following target nucleic acid samplepreparation, the sample is contacted with the array under hybridizationconditions, whereby complexes are formed between target nucleic acidsthat are complementary to probe sequences attached to the array surface.The presence of hybridized complexes is then detected, eitherqualitatively or quantitatively. Specific hybridization technology whichmay be practiced to generate the expression profiles employed in thesubject methods includes the technology described in U.S. Pat. Nos.5,143,854; 5,288,644; 5,324,633; 5,432,049; 5,470,710; 5,492,806;5,503,980; 5,510,270; 5,525,464; 5,547,839; 5,580,732; 5,661,028;5,800,992; the disclosures of which are herein incorporated byreference; as well as WO 95/21265; WO 96/31622; WO 97/10365; WO97/27317; EP 373 203; and EP 785 280. In these methods, an array of“probe” nucleic acids that includes a probe for each of the biomarkerswhose expression is being assayed is contacted with target nucleic acidsas described above. Contact is carried out under hybridizationconditions, e.g., stringent hybridization conditions as described above,and unbound nucleic acid is then removed. The resultant pattern ofhybridized nucleic acids provides information regarding expression foreach of the biomarkers that have been probed, where the expressioninformation is in terms of whether or not the gene is expressed and,typically, at what level, where the expression data, i.e., expressionprofile, may be both qualitative and quantitative.

Optimal hybridization conditions will depend on the length (e.g.,oligomer vs. polynucleotide greater than 200 bases) and type (e.g., RNA,DNA, PNA) of labeled probe and immobilized polynucleotide oroligonucleotide. General parameters for specific (i.e., stringent)hybridization conditions for nucleic acids are described in Sambrook etal., supra, and in Ausubel et al., “Current Protocols in MolecularBiology”, Greene Publishing and Wiley-interscience, NY (1987), which isincorporated in its entirety for all purposes. When the cDNA microarraysare used, typical hybridization conditions are hybridization in 5×SSCplus 0.2% SDS at 65C for 4 hours followed by washes at 25° C. in lowstringency wash buffer (1×SSC plus 0.2% SDS) followed by 10 minutes at25° C. in high stringency wash buffer (0.1SSC plus 0.2% SDS) (see Shenaet al., Proc. Natl. Acad. Sci. USA, Vol. 93, p. 10614 (1996)). Usefulhybridization conditions are also provided in, e.g., Tijessen,Hybridization With Nucleic Acid Probes”, Elsevier Science PublishersB.V. (1993) and Kricka, “Nonisotopic DNA Probe Techniques”, AcademicPress, San Diego, Calif. (1992).

RNA Sequencing

In certain embodiments, the invention involves targeted nucleic acidprofiling (e.g., sequencing, quantitative reverse transcriptionpolymerase chain reaction, and the like). In certain embodiments, atarget nucleic acid molecule (e.g., RNA molecule), may be sequenced byany method known in the art, for example, methods of high-throughputsequencing, also known as next generation sequencing or deep sequencing.A nucleic acid target molecule labeled with a barcode (for example, anorigin-specific barcode) can be sequenced with the barcode to produce asingle read and/or contig containing the sequence, or portions thereof,of both the target molecule and the barcode. Exemplary next generationsequencing technologies include, for example, Illumina sequencing, IonTorrent sequencing, 454 sequencing, SOLiD sequencing, and nanoporesequencing amongst others.

In certain embodiments, the invention involves single cell RNAsequencing (see, e.g., Kalisky, T., Blainey, P. & Quake, S. R. GenomicAnalysis at the Single-Cell Level. Annual review of genetics 45,431-445, (2011); Kalisky, T. & Quake, S. R. Single-cell genomics. NatureMethods 8, 311-314 (2011); Islam, S. et al. Characterization of thesingle-cell transcriptional landscape by highly multiplex RNA-seq.Genome Research, (2011); Tang, F. et al. RNA-Seq analysis to capture thetranscriptome landscape of a single cell. Nature Protocols 5, 516-535,(2010); Tang, F. et al. mRNA-Seq whole-transcriptome analysis of asingle cell. Nature Methods 6, 377-382, (2009); Ramskold, D. et al.Full-length mRNA-Seq from single-cell levels of RNA and individualcirculating tumor cells. Nature Biotechnology 30, 777-782, (2012); andHashimshony, T., Wagner, F., Sher, N. & Yanai, I. CEL-Seq: Single-CellRNA-Seq by Multiplexed Linear Amplification. Cell Reports, Cell Reports,Volume 2, Issue 3, p 666-673, 2012).

In certain embodiments, the invention involves plate based single cellRNA sequencing (see, e.g., Picelli, S. et al., 2014, “Full-lengthRNA-seq from single cells using Smart-seq2” Nature protocols 9, 171-181,doi:10.1038/nprot.2014.006).

In certain embodiments, the invention involves high-throughputsingle-cell RNA-seq. In this regard reference is made to Macosko et al.,2015, “Highly Parallel Genome-wide Expression Profiling of IndividualCells Using Nanoliter Droplets” Cell 161, 1202-1214; Internationalpatent application number PCT/US2015/049178, published as WO2016/040476on Mar. 17, 2016; Klein et al., 2015, “Droplet Barcoding for Single-CellTranscriptomics Applied to Embryonic Stem Cells” Cell 161, 1187-1201;International patent application number PCT/US2016/027734, published asWO2016168584A1 on Oct. 20, 2016; Zheng, et al., 2016, “Haplotypinggermline and cancer genomes with high-throughput linked-read sequencing”Nature Biotechnology 34, 303-311; Zheng, et al., 2017, “Massivelyparallel digital transcriptional profiling of single cells” Nat. Commun.8, 14049 doi: 10.1038/ncomms14049; International patent publicationnumber WO2014210353A2; Zilionis, et al., 2017, “Single-cell barcodingand sequencing using droplet microfluidics” Nat Protoc. Jan;12(1):44-73; Cao et al., 2017, “Comprehensive single celltranscriptional profiling of a multicellular organism by combinatorialindexing” bioRxiv preprint first posted online Feb. 2, 2017, doi:dx.doi.org/10.1101/104844; Rosenberg et al., 2017, “Scaling single celltranscriptomics through split pool barcoding” bioRxiv preprint firstposted online Feb. 2, 2017, doi: dx.doi.org/10.1101/105163; Rosenberg etal., “Single-cell profiling of the developing mouse brain and spinalcord with split-pool barcoding” Science 15 Mar. 2018; Vitak, et al.,“Sequencing thousands of single-cell genomes with combinatorialindexing” Nature Methods, 14(3):302-308, 2017; Cao, et al.,Comprehensive single-cell transcriptional profiling of a multicellularorganism. Science, 357(6352):661-667, 2017; and Gierahn et al.,“Seq-Well: portable, low-cost RNA sequencing of single cells at highthroughput” Nature Methods 14, 395-398 (2017), all the contents anddisclosure of each of which are herein incorporated by reference intheir entirety.

In certain embodiments, the invention involves single nucleus RNAsequencing. In this regard reference is made to Swiech et al., 2014, “Invivo interrogation of gene function in the mammalian brain usingCRISPR-Cas9” Nature Biotechnology Vol. 33, pp. 102-106; Habib et al.,2016, “Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adultnewborn neurons” Science, Vol. 353, Issue 6302, pp. 925-928; Habib etal., 2017, “Massively parallel single-nucleus RNA-seq with DroNc-seq”Nat Methods. 2017 October; 14(10):955-958; and International patentapplication number PCT/US2016/059239, published as WO2017164936 on Sep.28, 2017, which are herein incorporated by reference in their entirety.

An altered expression of one or more genome sequences associated with asignaling biochemical pathway can be determined by assaying for adifference in the mRNA levels of the corresponding genes between thetest model cell and a control cell, when they are contacted with acandidate agent. Alternatively, the differential expression of thesequences associated with a signaling biochemical pathway is determinedby detecting a difference in the level of the encoded polypeptide orgene product.

To assay for an agent-induced alteration in the level of mRNAtranscripts or corresponding polynucleotides, nucleic acid contained ina sample is first extracted according to standard methods in the art.For instance, mRNA can be isolated using various lytic enzymes orchemical solutions according to the procedures set forth in Sambrook etal. (1989), or extracted by nucleic-acid-binding resins following theaccompanying instructions provided by the manufacturers. The mRNAcontained in the extracted nucleic acid sample is then detected byamplification procedures or conventional hybridization assays (e.g.Northern blot analysis) according to methods widely known in the art orbased on the methods exemplified herein.

Detection of the gene expression level can be conducted in real time inan amplification assay. In one aspect, the amplified products can bedirectly visualized with fluorescent DNA-binding agents including butnot limited to DNA intercalators and DNA groove binders. Because theamount of the intercalators incorporated into the double-stranded DNAmolecules is typically proportional to the amount of the amplified DNAproducts, one can conveniently determine the amount of the amplifiedproducts by quantifying the fluorescence of the intercalated dye usingconventional optical systems in the art. DNA-binding dye suitable forthis application include SYBR green, SYBR blue, DAPI, propidium iodine,Hoeste, SYBR gold, ethidium bromide, acridines, proflavine, acridineorange, acriflavine, fluorcoumanin, ellipticine, daunomycin,chloroquine, distamycin D, chromomycin, homidium, mithramycin, rutheniumpolypyridyls, anthramycin, and the like.

In another aspect, other fluorescent labels such as sequence specificprobes can be employed in the amplification reaction to facilitate thedetection and quantification of the amplified products. Probe-basedquantitative amplification relies on the sequence-specific detection ofa desired amplified product. It utilizes fluorescent, target-specificprobes (e.g., TaqMan® probes) resulting in increased specificity andsensitivity. Methods for performing probe-based quantitativeamplification are well established in the art and are taught in U.S.Pat. No. 5,210,015.

An agent-induced change in expression of sequences associated with asignaling biochemical pathway can also be determined by examining thecorresponding gene products. Determining the protein level typicallyinvolves a) contacting the protein contained in a biological sample withan agent that specifically bind to a protein associated with a signalingbiochemical pathway; and (b) identifying any agent:protein complex soformed. In one aspect of this embodiment, the agent that specificallybinds a protein associated with a signaling biochemical pathway is anantibody, preferably a monoclonal antibody. The reaction is performed bycontacting the agent with a sample of the proteins associated with asignaling biochemical pathway derived from the test samples underconditions that will allow a complex to form between the agent and theproteins associated with a signaling biochemical pathway. The formationof the complex can be detected directly or indirectly according tostandard procedures in the art. In the direct detection method, theagents are supplied with a detectable label and unreacted agents may beremoved from the complex; the amount of remaining label therebyindicating the amount of complex formed. For such method, it ispreferable to select labels that remain attached to the agents evenduring stringent washing conditions. It is preferable that the labeldoes not interfere with the binding reaction. In the alternative, anindirect detection procedure may use an agent that contains a labelintroduced either chemically or enzymatically. A desirable labelgenerally does not interfere with binding or the stability of theresulting agent:polypeptide complex. However, the label is typicallydesigned to be accessible to an antibody for an effective binding andhence generating a detectable signal.

A wide variety of labels suitable for detecting protein levels are knownin the art. Non-limiting examples include radioisotopes, enzymes,colloidal metals, fluorescent compounds, bioluminescent compounds, andchemiluminescent compounds.

The amount of agent:polypeptide complexes formed during the bindingreaction can be quantified by standard quantitative assays. Asillustrated above, the formation of agent:polypeptide complex can bemeasured directly by the amount of label remained at the site ofbinding. In an alternative, the protein associated with a signalingbiochemical pathway is tested for its ability to compete with a labeledanalog for binding sites on the specific agent. In this competitiveassay, the amount of label captured is inversely proportional to theamount of protein sequences associated with a signaling biochemicalpathway present in a test sample

A number of techniques for protein analysis based on the generalprinciples outlined above are available in the art. They include but arenot limited to radioimmunoassays, ELISA (enzyme linked immunoradiometricassays), “sandwich” immunoassays, immunoradiometric assays, in situimmunoassays (using e.g., colloidal gold, enzyme or radioisotopelabels), western blot analysis, immunoprecipitation assays,immunofluorescent assays, and SDS-PAGE.

Antibodies that specifically recognize or bind to proteins associatedwith a signaling biochemical pathway are preferable for conducting theaforementioned protein analyses. Where desired, antibodies thatrecognize a specific type of post-translational modifications (e.g.,signaling biochemical pathway inducible modifications) can be used.Post-translational modifications include but are not limited toglycosylation, lipidation, acetylation, and phosphorylation. Theseantibodies may be purchased from commercial vendors. For example,anti-phosphotyrosine antibodies that specifically recognizetyrosine-phosphorylated proteins are available from a number of vendorsincluding Invitrogen and Perkin Elmer. Antiphosphotyrosine antibodiesare particularly useful in detecting proteins that are differentiallyphosphorylated on their tyrosine residues in response to an ER stress.Such proteins include but are not limited to eukaryotic translationinitiation factor 2 alpha. Alternatively, these antibodies can begenerated using conventional polyclonal or monoclonal antibodytechnologies by immunizing a host animal or an antibody-producing cellwith a target protein that exhibits the desired post-translationalmodification.

In practicing the subject method, it may be desirable to discern theexpression pattern of an protein associated with a signaling biochemicalpathway in different bodily tissue, in different cell types, and/or indifferent subcellular structures. These studies can be performed withthe use of tissue-specific, cell-specific or subcellular structurespecific antibodies capable of binding to protein markers that arepreferentially expressed in certain tissues, cell types, or subcellularstructures.

An altered expression of a gene associated with a signaling biochemicalpathway can also be determined by examining a change in activity of thegene product relative to a control cell. The assay for an agent-inducedchange in the activity of a protein associated with a signalingbiochemical pathway will dependent on the biological activity and/or thesignal transduction pathway that is under investigation. For example,where the protein is a kinase, a change in its ability to phosphorylatethe downstream substrate(s) can be determined by a variety of assaysknown in the art. Representative assays include but are not limited toimmunoblotting and immunoprecipitation with antibodies such asanti-phosphotyrosine antibodies that recognize phosphorylated proteins.In addition, kinase activity can be detected by high throughputchemiluminescent assays such as AlphaScreen™ (available from PerkinElmer) and eTag™ assay (Chan-Hui, et al. (2003) Clinical Immunology 111:162-174).

Where the protein associated with a signaling biochemical pathway ispart of a signaling cascade leading to a fluctuation of intracellular pHcondition, pH sensitive molecules such as fluorescent pH dyes can beused as the reporter molecules. In another example where the proteinassociated with a signaling biochemical pathway is an ion channel,fluctuations in membrane potential and/or intracellular ionconcentration can be monitored. A number of commercial kits andhigh-throughput devices are particularly suited for a rapid and robustscreening for modulators of ion channels. Representative instrumentsinclude FLIPR™ (Molecular Devices, Inc.) and VIPR (Aurora Biosciences).These instruments are capable of detecting reactions in over 1000 samplewells of a microplate simultaneously, and providing real-timemeasurement and functional data within a second or even a minisecond.

Systems and Devices

The systems described herein can be embodied on diagnostic devices. Anumber of substrates and configurations may be used. The devices may becapable of defining multiple individual discrete volumes within thedevice. As used herein an “individual discrete volume” refers to adiscrete space, such as a container, receptacle, or other defined volumeor space that can be defined by properties that prevent and/or inhibitmigration of target molecules, for example a volume or space defined byphysical properties such as walls, for example the walls of a well,tube, or a surface of a droplet, which may be impermeable orsemipermeable, or as defined by other means such as chemical, diffusionrate limited, electro-magnetic, or light illumination, or anycombination thereof that can contain a sample within a defined space.Individual discrete volumes may be identified by molecular tags, such asnucleic acid barcodes. By “diffusion rate limited” (for examplediffusion defined volumes) is meant spaces that are only accessible tocertain molecules or reactions because diffusion constraints effectivelydefining a space or volume as would be the case for two parallel laminarstreams where diffusion will limit the migration of a target moleculefrom one stream to the other. By “chemical” defined volume or space ismeant spaces where only certain target molecules can exist because oftheir chemical or molecular properties, such as size, where for examplegel beads may exclude certain species from entering the beads but notothers, such as by surface charge, matrix size or other physicalproperty of the bead that can allow selection of species that may enterthe interior of the bead. By “electro-magnetically” defined volume orspace is meant spaces where the electro-magnetic properties of thetarget molecules or their supports such as charge or magnetic propertiescan be used to define certain regions in a space such as capturingmagnetic particles within a magnetic field or directly on magnets. By“optically” defined volume is meant any region of space that may bedefined by illuminating it with visible, ultraviolet, infrared, or otherwavelengths of light such that only target molecules within the definedspace or volume may be labeled. One advantage to the use of non-walled,or semipermeable discrete volumes is that some reagents, such asbuffers, chemical activators, or other agents may be passed through thediscrete volume, while other materials, such as target molecules, may bemaintained in the discrete volume or space. Typically, a discrete volumewill include a fluid medium, (for example, an aqueous solution, an oil,a buffer, and/or a media capable of supporting cell growth) suitable forlabeling of the target molecule with the indexable nucleic acididentifier under conditions that permit labeling. Exemplary discretevolumes or spaces useful in the disclosed methods include droplets (forexample, microfluidic droplets and/or emulsion droplets), hydrogel beadsor other polymer structures (for example poly-ethylene glycoldi-acrylate beads or agarose beads), tissue slides (for example, fixedformalin paraffin embedded tissue slides with particular regions,volumes, or spaces defined by chemical, optical, or physical means),microscope slides with regions defined by depositing reagents in orderedarrays or random patterns, tubes (such as, centrifuge tubes,microcentrifuge tubes, test tubes, cuvettes, conical tubes, and thelike), bottles (such as glass bottles, plastic bottles, ceramic bottles,Erlenmeyer flasks, scintillation vials and the like), wells (such aswells in a plate), plates, pipettes, or pipette tips among others. Incertain embodiments, the compartment is an aqueous droplet in awater-in-oil emulsion. In specific embodiments, any of the applications,methods, or systems described herein requiring exact or uniform volumesmay employ the use of an acoustic liquid dispenser.

In certain example embodiments, the device comprises a flexible materialsubstrate on which a number of spots may be defined. Flexible substratematerials suitable for use in diagnostics and biosensing are knownwithin the art. The flexible substrate materials may be made of plantderived fibers, such as cellulosic fibers, or may be made from flexiblepolymers such as flexible polyester films and other polymer types.Within each defined spot, reagents of the system described herein areapplied to the individual spots. Each spot may contain the same reagentsexcept for a different guide RNA or set of guide RNAs, or whereapplicable, a different detection aptamer to screen for multiple targetsat once. Thus, the systems and devices herein may be able to screensamples from multiple sources (e.g. multiple clinical samples fromdifferent individuals) for the presence of the same target, or a limitednumber of targets, or aliquots of a single sample (or multiple samplesfrom the same source) for the presence of multiple different targets inthe sample. In certain example embodiments, the elements of the systemsdescribed herein are freeze dried onto the paper or cloth substrate.Example flexible material based substrates that may be used in certainexample devices are disclosed in Pardee et al. Cell. 2016,165(5):1255-66 and Pardee et al. Cell. 2014, 159(4):950-54. Suitableflexible material-based substrates for use with biological fluids,including blood are disclosed in International Patent ApplicationPublication No. WO/2013/071301 entitled “Paper based diagnostic test” toShevkoplyas et al. U.S. Patent Application Publication No. 2011/0111517entitled “Paper-based microfluidic systems” to Siegel et al. and Shafieeet al. “Paper and Flexible Substrates as Materials for BiosensingPlatforms to Detect Multiple Biotargets” Scientific Reports 5:8719(2015). Further flexible based materials, including those suitable foruse in wearable diagnostic devices are disclosed in Wang et al.“Flexible Substrate-Based Devices for Point-of-Care Diagnostics” Cell34(11):909-21 (2016). Further flexible based materials may includenitrocellulose, polycarbonate, methylethyl cellulose, polyvinylidenefluoride (PVDF), polystyrene, or glass (see e.g., US20120238008). Incertain embodiments, discrete volumes are separated by a hydrophobicsurface, such as but not limited to wax, photoresist, or solid ink.

In other example embodiments, the elements of the systems describedherein may be place on a single use substrate, such as swab or cloththat is used to swab a surface or sample fluid. For example, the systemcould be used to test for the presence of a pathogen on a food byswabbing the surface of a food product, such as a fruit or vegetable.Similarly, the single use substrate may be used to swab other surfacesfor detection of certain microbes or agents, such as for use in securityscreening. Single use substrates may also have applications inforensics, where the CRISPR systems are designed to detect, for exampleidentifying DNA SNPs that may be used to identify a suspect, or certaintissue or cell markers to determine the type of biological matterpresent in a sample. Likewise, the single use substrate could be used tocollect a sample from a patient—such as a saliva sample from themouth—or a swab of the skin. In other embodiments, a sample or swab maybe taken of a meat product on order to detect the presence of absence ofcontaminants on or within the meat product.

In certain example embodiments, a single guide sequences specific to asingle target is placed in separate volumes. Each volume may thenreceive a different sample or aliquot of the same sample. In certainexample embodiments, multiple guide sequences each to separate targetmay be placed in a single well such that multiple targets may bescreened in a different well. In order to detect multiple guide RNAs ina single volume, in certain example embodiments, multiple effectorproteins with different specificities may be used. For example,different orthologs with different sequence specificities may be used.For example, one orthologue may preferentially cut A, while otherspreferentially cut C, G, U/T. Accordingly, masking constructs completelycomprising, or comprised of a substantial portion, of a singlenucleotide may be generated, each with a different fluorophore that canbe detected at differing wavelengths. In this way, up to four differenttargets may be screened in a single individual discrete volume. Incertain example embodiments, different orthologues from a same class ofCRISPR effector protein may be used, such as two Cas13a orthologues, twoCas13b orthologues, or two Cas13c orthologues. The nucleotidepreferences of various Cas13 proteins is shown in FIGS. 67A and 67B. Incertain other example embodiments, different orthologues with differentnucleotide editing preferences may be used such as a Cas13a and Cas13borthologs, or a Cas13a and a Cas13c orthologs, or a Cas13b orthologs anda Cas13c orthologs etc. In certain example embodiments, a Cas13 proteinwith a polyU preference and a Cas13 protein with a polyA preference areused. In certain example embodiments, the Cas13 protein with a polyUpreference is a Prevotella intermedia Cas13b. and the Cas13 protein witha polyA preference is a Prevotella sp. MA2106 Cas13b protein(PsmCas13b). In certain example embodiments, the Cas13 protein with apolyU preference is a Leptotrichia wadei Cas13a (LwaCas13a) protein andthe Cas13 protein with a poly A preference is a Prevotella sp. MA2106Cas13b protein. In certain example embodiments, the Cas13 protein with apolyU preference is Capnocytophaga canimorsus Cas13b protein(CcaCas13b).

In certain embodiments, the systems, methods, and devices describedherein may be used to screen gene signatures that identify a particularcell type, cell phenotype, or cell state. Likewise, through the use ofsuch methods as compressed sensing, the embodiments disclosed herein maybe used to detect transcriptomes. Gene expression data are highlystructured, such that the expression level of some genes is predictiveof the expression level of others. Knowledge that gene expression dataare highly structured allows for the assumption that the number ofdegrees of freedom in the system are small, which allows for assumingthat the basis for computation of the relative gene abundances issparse. It is possible to make several biologically motivatedassumptions that allow Applicants to recover the nonlinear interactionterms while under-sampling without having any specific knowledge ofwhich genes are likely to interact. In particular, if Applicants assumethat genetic interactions are low rank, sparse, or a combination ofthese, then the true number of degrees of freedom is small relative tothe complete combinatorial expansion, which enables Applicants to inferthe full nonlinear landscape with a relatively small number ofperturbations. Working around these assumptions, analytical theories ofmatrix completion and compressed sensing may be used to designunder-sampled combinatorial perturbation experiments. In addition, akernel-learning framework may be used to employ under-sampling bybuilding predictive functions of combinatorial perturbations withoutdirectly learning any individual interaction coefficient Compressessensing provides a way to identify the minimal number of targettranscripts to be detected in order obtain a comprehensivegene-expression profile. Methods for compressed sensing are disclosed inPCT/US2016/059230 “Systems and Methods for Determining RelativeAbundances of Biomolecules” filed Oct. 27, 2016, which is incorporatedherein by reference. Having used methods like compressed sensing toidentify a minimal transcript target set, a set of corresponding guideRNAs may then be designed to detect said transcripts. Accordingly, incertain example embodiments, a method for obtaining a gene-expressionprofile of cell comprises detecting, using the embodiments disclosed,herein a minimal transcript set that provides a gene-expression profileof a cell or population of cells.

Therapeutic Methods

In certain embodiments, the identified signatures, biomarkers andpathways described herein are modulated in order to treat a subject inneed thereof, such as a subject suffering from cancer (e.g., alymphoma). In one aspect, the present invention provides for a method ofinhibiting tumor growth of a BCL-2-driven cancer in a subject in needthereof, the method comprising administering to said subject atherapeutically effective amount of one or more agents that induces orenhances expression, activity, and/or function of one or more BCL-2inhibitor resistance signature genes (see, Tables 1, 2, 3 and 4). Incertain embodiments, a resistant signature is shifted to a sensitivesignature. In certain embodiments, a combination treatment isadministered in order to overcome resistance to the primary treatment(e.g., a BCL-2 inhibitor in combination with an MCL1 inhibitor, ID2 orID3 agonist, or OXPHOS inhibitor).

The term “treat”, “treated,” “treating” or “treatment” is used herein tomean to relieve, reduce or alleviate at least one symptom of a diseasein a subject. For example, treatment can be diminishment of one orseveral symptoms of a disorder or complete eradication of a disorder,such as cancer. Within the meaning of the present invention, the term“treat” also denote to arrest, delay the onset (i.e., the period priorto clinical manifestation of a disease) and/or reduce the risk ofdeveloping or worsening a disease. The term “protect” is used herein tomean prevent delay or treat, or all, as appropriate, development orcontinuance or aggravation of a disease in a subject. Within the meaningof the present invention, the disease is associated with a cancer.

The term “subject” or “patient” is intended to include animals, whichare capable of suffering from or afflicted with a cancer or any disorderinvolving, directly or indirectly, a cancer. Examples of subjectsinclude mammals, e.g., humans, dogs, cows, horses, pigs, sheep, goats,cats, mice, rabbits, rats, and transgenic non-human animals. In certainembodiments, the subject is a human, e.g., a human having, at risk ofhaving, or potentially capable of having cancer.

The methods described herein may be applicable to the treatment,diagnosis, or prognosis of any cancer. The term “cancer” is used hereinto mean malignant solid tumors as well as hematological malignancies. Insome instances, the cancer is melanoma. The melanoma may be metastaticmelanoma. Additional examples of such tumors include but are not limitedto leukemias, lymphomas, myelomas, carcinomas, metastatic carcinomas,sarcomas, adenomas, nervous system cancers and genitourinary cancers. Inexemplary embodiments, the foregoing methods are useful in treatingadult and pediatric acute lymphoblastic leukemia, acute myeloidleukemia, adrenocortical carcinoma, AIDS-related cancers, anal cancer,cancer of the appendix, astrocytoma, basal cell carcinoma, bile ductcancer, bladder cancer, bone cancer, osteosarcoma, fibrous histiocytoma,brain cancer, brain stem glioma, cerebellar astrocytoma, malignantglioma, ependymoma, medulloblastoma, supratentorial primitiveneuroectodermal tumors, hypothalamic glioma, breast cancer, male breastcancer, bronchial adenomas, Burkitt lymphoma, carcinoid tumor, carcinomaof unknown origin, central nervous system lymphoma, cerebellarastrocytoma, malignant glioma, cervical cancer, childhood cancers,chronic lymphocytic leukemia, chronic myelogenous leukemia, chronicmyeloproliferative disorders, colorectal cancer, cutaneous T-celllymphoma, endometrial cancer, ependymoma, esophageal cancer, Ewingfamily tumors, extracranial germ cell tumor, extragonadal germ celltumor, extrahepatic bile duct cancer, intraocular melanoma,retinoblastoma, gallbladder cancer, gastric cancer, gastrointestinalstromal tumor, extracranial germ cell tumor, extragonadal germ celltumor, ovarian germ cell tumor, gestational trophoblastic tumor, glioma,hairy cell leukemia, head and neck cancer, hepatocellular cancer,Hodgkin lymphoma, non-Hodgkin lymphoma, hypopharyngeal cancer,hypothalamic and visual pathway glioma, intraocular melanoma, islet celltumors, Kaposi sarcoma, kidney cancer, renal cell cancer, laryngealcancer, lip and oral cavity cancer, small cell lung cancer, non-smallcell lung cancer, primary central nervous system lymphoma, Waldenstrommacroglobulinema, malignant fibrous histiocytoma, medulloblastoma,melanoma, Merkel cell carcinoma, malignant mesothelioma, squamous neckcancer, multiple endocrine neoplasia syndrome, multiple myeloma, mycosisfungoides, myelodysplastic syndromes, myeloproliferative disorders,chronic myeloproliferative disorders, nasal cavity and paranasal sinuscancer, nasopharyngeal cancer, neuroblastoma, oropharyngeal cancer,ovarian cancer, pancreatic cancer, parathyroid cancer, penile cancer,pharyngeal cancer, pheochromocytoma, pineoblastoma and supratentorialprimitive neuroectodermal tumors, pituitary cancer, plasma cellneoplasms, pleuropulmonary blastoma, prostate cancer, rectal cancer,rhabdomyosarcoma, salivary gland cancer, soft tissue sarcoma, uterinesarcoma, Sezary syndrome, non-melanoma skin cancer, small intestinecancer, squamous cell carcinoma, squamous neck cancer, supratentorialprimitive neuroectodermal tumors, testicular cancer, throat cancer,thymoma and thymic carcinoma, thyroid cancer, transitional cell cancer,trophoblastic tumors, urethral cancer, uterine cancer, uterine sarcoma,vaginal cancer, vulvar cancer, and Wilms tumor.

Therapeutic Agents

In certain embodiments, the present invention provides for one or moretherapeutic agents against single or combinations of targets identified.Targeting the identified combinations may provide for enhanced orotherwise previously unknown activity in the treatment of disease. Incertain embodiments, an agent against one of the targets in acombination may already be known or used clinically. In certainembodiments, targeting the combination may require less of the agent ascompared to the current standard of care and provide for less toxicityand improved treatment. In certain embodiments, the one or more agentscomprises a small molecule inhibitor, small molecule degrader (e.g.,PROTAC), genetic modifying agent, antibody, antibody fragment,antibody-like protein scaffold, aptamer, protein, or any combinationthereof.

The terms “therapeutic agent”, “therapeutic capable agent” or “treatmentagent” are used interchangeably and refer to a molecule or compound thatconfers some beneficial effect upon administration to a subject. Thebeneficial effect includes enablement of diagnostic determinations;amelioration of a disease, symptom, disorder, or pathological condition;reducing or preventing the onset of a disease, symptom, disorder orcondition; and generally counteracting a disease, symptom, disorder orpathological condition.

In one aspect, the present invention provides for a method of inhibitingtumor growth of a BCL-2-driven cancer in a subject in need thereofcomprising administering to the subject one or more agents capable ofinhibiting the oxidative phosphorylation system (OXPHOS). In certainembodiments, the method comprises administering to the subject acombination therapy comprising an inhibitor of BCL-2 and one or moreinhibitors selected from the group consisting of an AMPK inhibitor andmitochondrial electron transport chain (mETC) inhibitor.

In another aspect, the present invention provides for a method ofinhibiting tumor growth of a BCL-2-driven cancer in a subject in needthereof comprising administering to the subject a combination therapycomprising an inhibitor of BCL-2 and one or more NF kappa B inhibitors.

BCL-2

In certain embodiments, the present invention uses inhibitors of BCL-2to modulate BCL-2 driven tumors. Targeted and selective BCL-2 inhibitorsinclude, but are not limited to, antisense oligonucleotide drugs such asoblimersen, small molecule inhibitors such as ABT-737 and navitoclax(ABT-263) and mimetic drugs such as venetoclax (ABT-199).

Bcl-2 has been shown to interact with: BAK1, BCAP31, BCL2-like 1,BCL2L11, BECN1, BID, BMF, BNIP2, BNIP3, BNIPL, BAD, BAX, BIK, C-Raf,CAPN2, CASP8, Cdk1, HRK, IRS1, Myc, NR4A1, Noxa, PPP2CA, PSEN1, RAD9A,RRAS, RTN4, SMN1, SOD1, and TP53BP2.

Venetoclax resistance modulating agents are useful therapeutic tools incancers, as BCL-2 has been implicated in these indications. Unlikeoncogenes that promote uncontrolled cellular proliferation, BCL-2encodes an anti-apoptotic protein that inhibits cell death. Venetoclax,previously known as ABT-199 is the first FDA-approved treatment thattargets the B-cell lymphoma 2 (BCL-2) protein. The BCL-2 protein playsan important role in enabling CLL cells to survive.

BCL-2 plays a role in many tumor types. BCL-2 was first discovered as anoncogene in B-cell malignancies. It is also expressed in normal lymphoidcells including T-cells and BCL-2 inhibitors are useful for treatment.Accordingly, venetoclax resistance modulating agents are used to treatB-cell and T-cell malignancies. Moreover, the venetoclax resistancemodulating agents are used more generally in BCL-2 driven cancers withother BCL-2 inhibitors when resistance develops to those inhibitors.BCL-2 inhibitors includes, without limitation, navitoclax (ABT-263),obatoclax (GX15-070), and gossypol compounds. (See e.g., Lampson et al.,“The Development and Current Use of BCL-2 Inhibitors for the Treatmentof Chronic Lymphocytic Leukemia.” Curr Hematol Malig Rep. 2017 February;12(1): 11-19. doi:10.1007/s11899-017-0359-0). Furthermore, theresistance modulating agents are more generally used in combination withBCL-2 inhibitors at a stage where resistance has not developed.Moreover, the agents can be used with BCL-2 inhibitors in cancers thatotherwise are not responsive to BCL-2 inhibition.

BCL2 is expressed in non-lymphoid cells and has been described inneuronal tumors. (See, e.g., I. Garcia, I. Martinou, Y. Tsujimoto, andJ. Martinou, “Prevention of programmed cell death of sympathetic neuronsby the bcl-2 proto-oncogene,” Science, vol. 258, no. 5080, pp. 302-304,1992.) Accordingly, resistance modulating agents according to theinvention can be combined with BCL2 inhibitors, more generallyBCL2-family inhibitors for treatment of such tumor types.

Expression of BCL2 in normal epithelium indicates that BCL2 is expressedin carcinoma. For example, high expression of BCL2 is found in prostatecancer, including in androgen-independent tumors. (See, e.g., T. J.McDonnell, P. Troncoso, S. M. Brisbay et al., “Expression of theprotooncogene bcl-2 in the prostate and its association with emergenceof androgen-independent prostate cancer,” Cancer Research, vol. 52, no.24, pp. 6940-6944, 1992.)

High BCL2 expression has been reported in many different tumor typesincluding non-small cell and small lcell lung cancer (See, e.g., F.Pezzella, H. Turley, I. Kuzu et al., “bcl-2 protein in non-small-celllung carcinoma,” The New England Journal of Medicine, vol. 329, no. 10,pp. 690-694, 1993; N. Ikegaki, M. Katsumata, J. Minna, and Y. Tsujimoto,“Expression of bcl-2 in small cell lung carcinoma cells,” CancerResearch, vol. 54, no. 1, pp. 6-8, 1994.) BCL-2 expression is observedin ovarian cancer (See, e.g., Y. Kuwashima, T. Uehara, K. Kishi, K.Shiromizu, M. Matsuzawa, and S. Takayama, “Immunohistochemicalcharacterization of undifferentiated carcinomas of the ovary,” Journalof Cancer Research and Clinical Oncology, vol. 120, no. 11, pp. 672-677,1994.) and breast cancer (See, e.g., P. Monaghan, D. Robertson, T. A. S.Amos, M. J. S. Dyer, D. Y. Mason, and M. F. Greaves, “Ultrastructurallocalization of BCL-2 protein,” Journal of Histochemistry andCytochemistry, vol. 40, no. 12, pp. 1819-1825, 1992.). The function ofBCL2 in inhibiting apoptosis has been proven in many independentstudies, for example, by overexpression or knockdown. (See, e.g., R.X.-D. Song, Z. Zhang, G. Mor, and R. J. Santen, “Down-regulation ofBcl-2 enhances estrogen apoptotic action in long-term estradiol-depletedER⁺ breast cancer cells,” Apoptosis, vol. 10, no. 3, pp. 667-678, 2005.)Accordingly, resistance modulating agents according to the invention canbe combined with BCL2 inhibitors, more generally BCL2-family inhibitorsfor treatment of such tumor types. In certain such embodiments, thecontributions of the BCL-2 or BCL-2 family inhibitor and resistancemodulating agents are additive. In other embodiments, the contributionsare synergistic. In certain embodiments, the resistance modulating agenteffects or enables the action of the BCL-2 or BCL-2 family inhibitor,i.e. the effect of the inhibitor is observed when the resistancemodulating agent is present.

NF kappa B (NF-κB)

In certain embodiments, the present invention uses inhibitors of NFkappa B to modulate BCL-2 driven tumors. As discussed further herein,NKBIA was identified in the loss-of-function screen for BCL-2 inhibitorresistance. Thus, loss of an inhibitor of NF kappa B provided forresistance to BCL-2 inhibition. Protein inhibitors of NF kappa Bactivity include, but are not limited to, IFRD1 and SIRT1. Other drugsthat inhibit NF kappa B activity include, but are not limited to,denosumab, disulfiram, olmesartan, dithiocarbamates, anatabine, BAY11-7082 and iguratimod. In certain embodiments, a combination therapycomprising an NF kappa B inhibitor and BCL-2 inhibitor is used to treata subject in need thereof.

Oxidative Phosphorylation

In certain embodiments, the present invention uses inhibitors ofoxidative phosphorylation to modulate BCL-2 driven tumors. OXPHOSInhibitors for use in treating cancer have been described and areapplicable to the present invention (see, e.g., Nayak et al., OxidativePhosphorylation: A Target for Novel Therapeutic Strategies AgainstOvarian Cancer. Cancers (Basel). 2018 September; 10(9): 337). In certainembodiments, inhibitors of oxidative phosphorylation include, but arenot limited to biguanides, atovaquone, plumbagin, thiazolidinediones andubiquinone. Complex I Biguanides include metformin, proguanil, andIACS-0107059. Thiazolidinediones include rosiglitazone. Dorsomorphin isa cell-permeable and reversible ATP-competitive inhibitor ofAMP-activated protein kinase (AMPK) with Ki value of 10⁹ nM (see, e.g.,Lu Y, Akinwumi B C, Shao Z, Anderson H D. Ligand Activation ofCannabinoid Receptors Attenuates Hypertrophy of Neonatal RatCardiomyocytes. J Cardiovasc Pharmacol. 2014 Jun. 26). Oligomycin is aspecific inhibitor of the ATPase and blocks proton translocation leadingto a hyperpolarization of the inner mitochondrial membrane. Antimycin Ais an inhibitor of cellular respiration, specifically oxidativephosphorylation. Antimycin A binds to the Qi site of cytochrome creductase, inhibiting the oxidation of ubiquinone in the Qi site ofubiquinol thereby disrupting the Q-cycle of enzyme turn over.

MCL-1

Myeloid cell leukemia-1 (MCL-1), a member of anti-apoptotic BCL-2 familyproteins, is a key regulator of mitochondrial homeostasis and isfrequently overexpressed in human primary and drug-resistant cancercells (see, e.g., Xiang et al., MCL-1 inhibition in cancer treatment.Onco Targets Ther. 2018; 11: 7301-7314). Non-limiting inhibitors includeAT-101, TW-37, GA, Sabutoclax (BI-97C1), maritoclax, UMI-77, A-1210477,MIK665/S64315 and S63845, AMG176, and AZD5991. Previous studies havedescribed venetoclax and MCL-1 inhibition (see, e.g., Luedtke et al.,Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selectiveinhibitor ABT-199 in acute myeloid leukemia cells. Signal TransductTarget Ther. 2017; 2( ):17012).

Small Molecules

In certain embodiments, the one or more agents is a small molecule. Theterm “small molecule” refers to compounds, preferably organic compounds,with a size comparable to those organic molecules generally used inpharmaceuticals. The term excludes biological macromolecules (e.g.,proteins, peptides, nucleic acids, etc.). Preferred small organicmolecules range in size up to about 5000 Da, e.g., up to about 4000,preferably up to 3000 Da, more preferably up to 2000 Da, even morepreferably up to about 1000 Da, e.g., up to about 900, 800, 700, 600 orup to about 500 Da. In certain embodiments, the small molecule may actas an antagonist or agonist (e.g., blocking an enzyme active site oractivating a receptor by binding to a ligand binding site).

One type of small molecule applicable to the present invention is adegrader molecule. Proteolysis Targeting Chimera (PROTAC) technology isa rapidly emerging alternative therapeutic strategy with the potentialto address many of the challenges currently faced in modern drugdevelopment programs. PROTAC technology employs small molecules thatrecruit target proteins for ubiquitination and removal by the proteasome(see, e.g., Zhou et al., Discovery of a Small-Molecule Degrader ofBromodomain and Extra-Terminal (BET) Proteins with Picomolar CellularPotencies and Capable of Achieving Tumor Regression. J. Med. Chem. 2018,61, 462-481; Bondeson and Crews, Targeted Protein Degradation by SmallMolecules, Annu Rev Pharmacol Toxicol. 2017 Jan. 6; 57: 107-123; and Laiet al., Modular PROTAC Design for the Degradation of Oncogenic BCR-ABLAngew Chem Int Ed Engl. 2016 Jan. 11; 55(2): 807-810).

Genetic Modifying Agents

In certain embodiments, the one or more modulating agents may be agenetic modifying agent. The genetic modifying agent may comprise aCRISPR system, a zinc finger nuclease system, a TALEN, a meganuclease orRNAi system.

In general, a CRISPR-Cas or CRISPR system as used in herein and indocuments, such as WO 2014/093622 (PCT/US2013/074667), referscollectively to transcripts and other elements involved in theexpression of or directing the activity of CRISPR-associated (“Cas”)genes, including sequences encoding a Cas gene, a tracr(trans-activating CRISPR) sequence (e.g. tracrRNA or an active partialtracrRNA), a tracr-mate sequence (encompassing a “direct repeat” and atracrRNA-processed partial direct repeat in the context of an endogenousCRISPR system), a guide sequence (also referred to as a “spacer” in thecontext of an endogenous CRISPR system), or “RNA(s)” as that term isherein used (e.g., RNA(s) to guide Cas, such as Cas9, e.g. CRISPR RNAand transactivating (tracr) RNA or a single guide RNA (sgRNA) (chimericRNA)) or other sequences and transcripts from a CRISPR locus. Ingeneral, a CRISPR system is characterized by elements that promote theformation of a CRISPR complex at the site of a target sequence (alsoreferred to as a protospacer in the context of an endogenous CRISPRsystem). See, e.g, Shmakov et al. (2015) “Discovery and FunctionalCharacterization of Diverse Class 2 CRISPR-Cas Systems”, Molecular Cell,DOI: dx.doi.org/10.1016/j.molcel.2015.10.008.

In certain embodiments, a protospacer adjacent motif (PAM) or PAM-likemotif directs binding of the effector protein complex as disclosedherein to the target locus of interest. In some embodiments, the PAM maybe a 5′ PAM (i.e., located upstream of the 5′ end of the protospacer).In other embodiments, the PAM may be a 3′ PAM (i.e., located downstreamof the 5′ end of the protospacer). The term “PAM” may be usedinterchangeably with the term “PFS” or “protospacer flanking site” or“protospacer flanking sequence”.

In a preferred embodiment, the CRISPR effector protein may recognize a3′ PAM. In certain embodiments, the CRISPR effector protein mayrecognize a 3′ PAM which is 5′H, wherein His A, C or U.

In the context of formation of a CRISPR complex, “target sequence”refers to a sequence to which a guide sequence is designed to havecomplementarity, where hybridization between a target sequence and aguide sequence promotes the formation of a CRISPR complex. A targetsequence may comprise RNA polynucleotides. The term “target RNA” refersto a RNA polynucleotide being or comprising the target sequence. Inother words, the target RNA may be a RNA polynucleotide or a part of aRNA polynucleotide to which a part of the gRNA, i.e. the guide sequence,is designed to have complementarity and to which the effector functionmediated by the complex comprising CRISPR effector protein and a gRNA isto be directed. In some embodiments, a target sequence is located in thenucleus or cytoplasm of a cell.

In certain example embodiments, the CRISPR effector protein may bedelivered using a nucleic acid molecule encoding the CRISPR effectorprotein. The nucleic acid molecule encoding a CRISPR effector protein,may advantageously be a codon optimized CRISPR effector protein. Anexample of a codon optimized sequence, is in this instance a sequenceoptimized for expression in eukaryote, e.g., humans (i.e. beingoptimized for expression in humans), or for another eukaryote, animal ormammal as herein discussed; see, e.g., SaCas9 human codon optimizedsequence in WO 2014/093622 (PCT/US2013/074667). Whilst this ispreferred, it will be appreciated that other examples are possible andcodon optimization for a host species other than human, or for codonoptimization for specific organs is known. In some embodiments, anenzyme coding sequence encoding a CRISPR effector protein is a codonoptimized for expression in particular cells, such as eukaryotic cells.The eukaryotic cells may be those of or derived from a particularorganism, such as a plant or a mammal, including but not limited tohuman, or non-human eukaryote or animal or mammal as herein discussed,e.g., mouse, rat, rabbit, dog, livestock, or non-human mammal orprimate. In some embodiments, processes for modifying the germ linegenetic identity of human beings and/or processes for modifying thegenetic identity of animals which are likely to cause them sufferingwithout any substantial medical benefit to man or animal, and alsoanimals resulting from such processes, may be excluded. In general,codon optimization refers to a process of modifying a nucleic acidsequence for enhanced expression in the host cells of interest byreplacing at least one codon (e.g. about or more than about 1, 2, 3, 4,5, 10, 15, 20, 25, 50, or more codons) of the native sequence withcodons that are more frequently or most frequently used in the genes ofthat host cell while maintaining the native amino acid sequence. Variousspecies exhibit particular bias for certain codons of a particular aminoacid. Codon bias (differences in codon usage between organisms) oftencorrelates with the efficiency of translation of messenger RNA (mRNA),which is in turn believed to be dependent on, among other things, theproperties of the codons being translated and the availability ofparticular transfer RNA (tRNA) molecules. The predominance of selectedtRNAs in a cell is generally a reflection of the codons used mostfrequently in peptide synthesis. Accordingly, genes can be tailored foroptimal gene expression in a given organism based on codon optimization.Codon usage tables are readily available, for example, at the “CodonUsage Database” available at kazusa.orjp/codon/ and these tables can beadapted in a number of ways. See Nakamura, Y., et al. “Codon usagetabulated from the international DNA sequence databases: status for theyear 2000” Nucl. Acids Res. 28:292 (2000). Computer algorithms for codonoptimizing a particular sequence for expression in a particular hostcell are also available, such as Gene Forge (Aptagen; Jacobus, Pa.), arealso available. In some embodiments, one or more codons (e.g. 1, 2, 3,4, 5, 10, 15, 20, 25, 50, or more, or all codons) in a sequence encodinga Cas correspond to the most frequently used codon for a particularamino acid.

In certain embodiments, the methods as described herein may compriseproviding a Cas transgenic cell in which one or more nucleic acidsencoding one or more guide RNAs are provided or introduced operablyconnected in the cell with a regulatory element comprising a promoter ofone or more gene of interest. As used herein, the term “Cas transgeniccell” refers to a cell, such as a eukaryotic cell, in which a Cas genehas been genomically integrated. The nature, type, or origin of the cellare not particularly limiting according to the present invention. Alsothe way the Cas transgene is introduced in the cell may vary and can beany method as is known in the art. In certain embodiments, the Castransgenic cell is obtained by introducing the Cas transgene in anisolated cell. In certain other embodiments, the Cas transgenic cell isobtained by isolating cells from a Cas transgenic organism. By means ofexample, and without limitation, the Cas transgenic cell as referred toherein may be derived from a Cas transgenic eukaryote, such as a Casknock-in eukaryote. Reference is made to WO 2014/093622(PCT/US13/74667), incorporated herein by reference. Methods of US PatentPublication Nos. 20120017290 and 20110265198 assigned to SangamoBioSciences, Inc. directed to targeting the Rosa locus may be modifiedto utilize the CRISPR Cas system of the present invention. Methods of USPatent Publication No. 20130236946 assigned to Cellect is directed totargeting the Rosa locus may also be modified to utilize the CRISPR Cassystem of the present invention. By means of further example referenceis made to Platt et. al. (Cell; 159(2):440-455 (2014)), describing aCas9 knock-in mouse, which is incorporated herein by reference. The Castransgene can further comprise a Lox-Stop-polyA-Lox(LSL) cassettethereby rendering Cas expression inducible by Cre recombinase.Alternatively, the Cas transgenic cell may be obtained by introducingthe Cas transgene in an isolated cell. Delivery systems for transgenesare well known in the art. By means of example, the Cas transgene may bedelivered in for instance eukaryotic cell by means of vector (e.g., AAV,adenovirus, lentivirus) and/or particle and/or nanoparticle delivery, asalso described herein elsewhere.

It will be understood by the skilled person that the cell, such as theCas transgenic cell, as referred to herein may comprise further genomicalterations besides having an integrated Cas gene or the mutationsarising from the sequence specific action of Cas when complexed with RNAcapable of guiding Cas to a target locus.

In certain aspects the invention involves vectors, e.g. for deliveringor introducing in a cell Cas and/or RNA capable of guiding Cas to atarget locus (i.e. guide RNA), but also for propagating these components(e.g. in prokaryotic cells). A used herein, a “vector” is a tool thatallows or facilitates the transfer of an entity from one environment toanother. It is a replicon, such as a plasmid, phage, or cosmid, intowhich another DNA segment may be inserted so as to bring about thereplication of the inserted segment. Generally, a vector is capable ofreplication when associated with the proper control elements. Ingeneral, the term “vector” refers to a nucleic acid molecule capable oftransporting another nucleic acid to which it has been linked. Vectorsinclude, but are not limited to, nucleic acid molecules that aresingle-stranded, double-stranded, or partially double-stranded; nucleicacid molecules that comprise one or more free ends, no free ends (e.g.circular); nucleic acid molecules that comprise DNA, RNA, or both; andother varieties of polynucleotides known in the art. One type of vectoris a “plasmid,” which refers to a circular double stranded DNA loop intowhich additional DNA segments can be inserted, such as by standardmolecular cloning techniques. Another type of vector is a viral vector,wherein virally-derived DNA or RNA sequences are present in the vectorfor packaging into a virus (e.g. retroviruses, replication defectiveretroviruses, adenoviruses, replication defective adenoviruses, andadeno-associated viruses (AAVs)). Viral vectors also includepolynucleotides carried by a virus for transfection into a host cell.Certain vectors are capable of autonomous replication in a host cellinto which they are introduced (e.g. bacterial vectors having abacterial origin of replication and episomal mammalian vectors). Othervectors (e.g., non-episomal mammalian vectors) are integrated into thegenome of a host cell upon introduction into the host cell, and therebyare replicated along with the host genome. Moreover, certain vectors arecapable of directing the expression of genes to which they areoperatively-linked. Such vectors are referred to herein as “expressionvectors.” Common expression vectors of utility in recombinant DNAtechniques are often in the form of plasmids.

Recombinant expression vectors can comprise a nucleic acid of theinvention in a form suitable for expression of the nucleic acid in ahost cell, which means that the recombinant expression vectors includeone or more regulatory elements, which may be selected on the basis ofthe host cells to be used for expression, that is operatively-linked tothe nucleic acid sequence to be expressed. Within a recombinantexpression vector, “operably linked” is intended to mean that thenucleotide sequence of interest is linked to the regulatory element(s)in a manner that allows for expression of the nucleotide sequence (e.g.in an in vitro transcription/translation system or in a host cell whenthe vector is introduced into the host cell). With regards torecombination and cloning methods, mention is made of U.S. patentapplication Ser. No. 10/815,730, published Sep. 2, 2004 as US2004-0171156 A1, the contents of which are herein incorporated byreference in their entirety. Thus, the embodiments disclosed herein mayalso comprise transgenic cells comprising the CRISPR effector system. Incertain example embodiments, the transgenic cell may function as anindividual discrete volume. In other words samples comprising a maskingconstruct may be delivered to a cell, for example in a suitable deliveryvesicle and if the target is present in the delivery vesicle the CRISPReffector is activated and a detectable signal generated.

The vector(s) can include the regulatory element(s), e.g., promoter(s).The vector(s) can comprise Cas encoding sequences, and/or a single, butpossibly also can comprise at least 3 or 8 or 16 or 32 or 48 or 50 guideRNA(s) (e.g., sgRNAs) encoding sequences, such as 1-2, 1-3, 1-4 1-5,3-6, 3-7, 3-8, 3-9, 3-10, 3-8, 3-16, 3-30, 3-32, 3-48, 3-50 RNA(s)(e.g., sgRNAs). In a single vector there can be a promoter for each RNA(e.g., sgRNA), advantageously when there are up to about 16 RNA(s); and,when a single vector provides for more than 16 RNA(s), one or morepromoter(s) can drive expression of more than one of the RNA(s), e.g.,when there are 32 RNA(s), each promoter can drive expression of twoRNA(s), and when there are 48 RNA(s), each promoter can drive expressionof three RNA(s). By simple arithmetic and well established cloningprotocols and the teachings in this disclosure one skilled in the artcan readily practice the invention as to the RNA(s) for a suitableexemplary vector such as AAV, and a suitable promoter such as the U6promoter. For example, the packaging limit of AAV is ˜4.7 kb. The lengthof a single U6-gRNA (plus restriction sites for cloning) is 361 bp.Therefore, the skilled person can readily fit about 12-16, e.g., 13U6-gRNA cassettes in a single vector. This can be assembled by anysuitable means, such as a golden gate strategy used for TALE assembly(genome-engineering.org/taleffectors/). The skilled person can also usea tandem guide strategy to increase the number of U6-gRNAs byapproximately 1.5 times, e.g., to increase from 12-16, e.g., 13 toapproximately 18-24, e.g., about 19 U6-gRNAs. Therefore, one skilled inthe art can readily reach approximately 18-24, e.g., about 19promoter-RNAs, e.g., U6-gRNAs in a single vector, e.g., an AAV vector. Afurther means for increasing the number of promoters and RNAs in avector is to use a single promoter (e.g., U6) to express an array ofRNAs separated by cleavable sequences. And an even further means forincreasing the number of promoter-RNAs in a vector, is to express anarray of promoter-RNAs separated by cleavable sequences in the intron ofa coding sequence or gene; and, in this instance it is advantageous touse a polymerase II promoter, which can have increased expression andenable the transcription of long RNA in a tissue specific manner. (see,e.g., nar.oxfordjournals.org/content/34/7/e53.short andnature.com/mt/journal/v16/n9/abs/mt2008144a.html). In an advantageousembodiment, AAV may package U6 tandem gRNA targeting up to about 50genes. Accordingly, from the knowledge in the art and the teachings inthis disclosure the skilled person can readily make and use vector(s),e.g., a single vector, expressing multiple RNAs or guides under thecontrol or operatively or functionally linked to one or morepromoters-especially as to the numbers of RNAs or guides discussedherein, without any undue experimentation.

The guide RNA(s) encoding sequences and/or Cas encoding sequences, canbe functionally or operatively linked to regulatory element(s) and hencethe regulatory element(s) drive expression. The promoter(s) can beconstitutive promoter(s) and/or conditional promoter(s) and/or induciblepromoter(s) and/or tissue specific promoter(s). The promoter can beselected from the group consisting of RNA polymerases, pol I, pol II,pol III, T7, U6, H1, retroviral Rous sarcoma virus (RSV) LTR promoter,the cytomegalovirus (CMV) promoter, the SV40 promoter, the dihydrofolatereductase promoter, the β-actin promoter, the phosphoglycerol kinase(PGK) promoter, and the EF1α promoter. An advantageous promoter is thepromoter is U6.

Additional effectors for use according to the invention can beidentified by their proximity to cas1 genes, for example, though notlimited to, within the region 20 kb from the start of the cas1 gene and20 kb from the end of the cas1 gene. In certain embodiments, theeffector protein comprises at least one HEPN domain and at least 500amino acids, and wherein the C2c2 effector protein is naturally presentin a prokaryotic genome within 20 kb upstream or downstream of a Casgene or a CRISPR array. Non-limiting examples of Cas proteins includeCas1, Cas1B, Cas2, Cas3, Cas4, Cas5, Cas6, Cas7, Cas8, Cas9 (also knownas Csn1 and Csx12), Cas10, Csy1, Csy2, Csy3, Cse1, Cse2, Csc1, Csc2,Csa5, Csn2, Csm2, Csm3, Csm4, Csm5, Csm6, Cmr1, Cmr3, Cmr4, Cmr5, Cmr6,Csb1, Csb2, Csb3, Csx17, Csx14, Csx10, Csx16, CsaX, Csx3, Csx1, Csx15,Csf1, Csf2, Csf3, Csf4, homologues thereof, or modified versionsthereof. In certain example embodiments, the C2c2 effector protein isnaturally present in a prokaryotic genome within 20 kb upstream ordownstream of a Cas 1 gene. The terms “orthologue” (also referred to as“ortholog” herein) and “homologue” (also referred to as “homolog”herein) are well known in the art. By means of further guidance, a“homologue” of a protein as used herein is a protein of the same specieswhich performs the same or a similar function as the protein it is ahomologue of. Homologous proteins may but need not be structurallyrelated, or are only partially structurally related. An “orthologue” ofa protein as used herein is a protein of a different species whichperforms the same or a similar function as the protein it is anorthologue of Orthologous proteins may but need not be structurallyrelated, or are only partially structurally related.

Guide Molecules

The methods described herein may be used to screen inhibition of CRISPRsystems employing different types of guide molecules. As used herein,the term “guide sequence” and “guide molecule” in the context of aCRISPR-Cas system, comprises any polynucleotide sequence havingsufficient complementarity with a target nucleic acid sequence tohybridize with the target nucleic acid sequence and directsequence-specific binding of a nucleic acid-targeting complex to thetarget nucleic acid sequence. The guide sequences made using the methodsdisclosed herein may be a full-length guide sequence, a truncated guidesequence, a full-length sgRNA sequence, a truncated sgRNA sequence, oran E+F sgRNA sequence. In some embodiments, the degree ofcomplementarity of the guide sequence to a given target sequence, whenoptimally aligned using a suitable alignment algorithm, is about or morethan about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or more. Incertain example embodiments, the guide molecule comprises a guidesequence that may be designed to have at least one mismatch with thetarget sequence, such that a RNA duplex formed between the guidesequence and the target sequence. Accordingly, the degree ofcomplementarity is preferably less than 99%. For instance, where theguide sequence consists of 24 nucleotides, the degree of complementarityis more particularly about 96% or less. In particular embodiments, theguide sequence is designed to have a stretch of two or more adjacentmismatching nucleotides, such that the degree of complementarity overthe entire guide sequence is further reduced. For instance, where theguide sequence consists of 24 nucleotides, the degree of complementarityis more particularly about 96% or less, more particularly, about 92% orless, more particularly about 88% or less, more particularly about 84%or less, more particularly about 80% or less, more particularly about76% or less, more particularly about 72% or less, depending on whetherthe stretch of two or more mismatching nucleotides encompasses 2, 3, 4,5, 6 or 7 nucleotides, etc. In some embodiments, aside from the stretchof one or more mismatching nucleotides, the degree of complementarity,when optimally aligned using a suitable alignment algorithm, is about ormore than about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or more.Optimal alignment may be determined with the use of any suitablealgorithm for aligning sequences, non-limiting example of which includethe Smith-Waterman algorithm, the Needleman-Wunsch algorithm, algorithmsbased on the Burrows-Wheeler Transform (e.g., the Burrows WheelerAligner), ClustalW, Clustal X, BLAT, Novoalign (Novocraft Technologies;available at www.novocraft.com), ELAND (Illumina, San Diego, Calif.),SOAP (available at soap.genomics.org.cn), and Maq (available atmaq.sourceforge.net). The ability of a guide sequence (within a nucleicacid-targeting guide RNA) to direct sequence-specific binding of anucleic acid-targeting complex to a target nucleic acid sequence may beassessed by any suitable assay. For example, the components of a nucleicacid-targeting CRISPR system sufficient to form a nucleic acid-targetingcomplex, including the guide sequence to be tested, may be provided to ahost cell having the corresponding target nucleic acid sequence, such asby transfection with vectors encoding the components of the nucleicacid-targeting complex, followed by an assessment of preferentialtargeting (e.g., cleavage) within the target nucleic acid sequence, suchas by Surveyor assay as described herein. Similarly, cleavage of atarget nucleic acid sequence (or a sequence in the vicinity thereof) maybe evaluated in a test tube by providing the target nucleic acidsequence, components of a nucleic acid-targeting complex, including theguide sequence to be tested and a control guide sequence different fromthe test guide sequence, and comparing binding or rate of cleavage at orin the vicinity of the target sequence between the test and controlguide sequence reactions. Other assays are possible, and will occur tothose skilled in the art. A guide sequence, and hence a nucleicacid-targeting guide RNA may be selected to target any target nucleicacid sequence.

In certain embodiments, the guide sequence or spacer length of the guidemolecules is from 15 to 50 nt. In certain embodiments, the spacer lengthof the guide RNA is at least 15 nucleotides. In certain embodiments, thespacer length is from 15 to 17 nt, e.g., 15, 16, or 17 nt, from 17 to 20nt, e.g., 17, 18, 19, or 20 nt, from 20 to 24 nt, e.g., 20, 21, 22, 23,or 24 nt, from 23 to 25 nt, e.g., 23, 24, or 25 nt, from 24 to 27 nt,e.g., 24, 25, 26, or 27 nt, from 27-30 nt, e.g., 27, 28, 29, or 30 nt,from 30-35 nt, e.g., 30, 31, 32, 33, 34, or 35 nt, or 35 nt or longer.In certain example embodiment, the guide sequence is 15, 16, 17, 18, 19,20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,38, 39 40, 41, 42, 43, 44, 45, 46, 47 48, 49, 50, 51, 52, 53, 54, 55,56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73,74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91,92, 93, 94, 95, 96, 97, 98, 99, or 100 nt.

In some embodiments, the guide sequence is an RNA sequence of between 10to 50 nt in length, but more particularly of about 20-30 ntadvantageously about 20 nt, 23-25 nt or 24 nt. The guide sequence isselected so as to ensure that it hybridizes to the target sequence. Thisis described more in detail below. Selection can encompass further stepswhich increase efficacy and specificity.

In some embodiments, the guide sequence has a canonical length (e.g.,about 15-30 nt) is used to hybridize with the target RNA or DNA. In someembodiments, a guide molecule is longer than the canonical length(e.g., >30 nt) is used to hybridize with the target RNA or DNA, suchthat a region of the guide sequence hybridizes with a region of the RNAor DNA strand outside of the Cas-guide target complex. This can be ofinterest where additional modifications, such deamination of nucleotidesis of interest. In alternative embodiments, it is of interest tomaintain the limitation of the canonical guide sequence length.

In some embodiments, the sequence of the guide molecule (direct repeatand/or spacer) is selected to reduce the degree secondary structurewithin the guide molecule. In some embodiments, about or less than about75%, 50%, 40%, 30%, 25%, 20%, 15%, 10%, 5%, 1%, or fewer of thenucleotides of the nucleic acid-targeting guide RNA participate inself-complementary base pairing when optimally folded. Optimal foldingmay be determined by any suitable polynucleotide folding algorithm. Someprograms are based on calculating the minimal Gibbs free energy. Anexample of one such algorithm is mFold, as described by Zuker andStiegler (Nucleic Acids Res. 9 (1981), 133-148). Another example foldingalgorithm is the online webserver RNAfold, developed at Institute forTheoretical Chemistry at the University of Vienna, using the centroidstructure prediction algorithm (see e.g., A. R. Gruber et al., 2008,Cell 106(1): 23-24; and P A Carr and G M Church, 2009, NatureBiotechnology 27(12): 1151-62).

In some embodiments, it is of interest to reduce the susceptibility ofthe guide molecule to RNA cleavage, such as to cleavage by Cas13.Accordingly, in particular embodiments, the guide molecule is adjustedto avoid cleavage by Cas13 or other RNA-cleaving enzymes.

In certain embodiments, the guide molecule comprises non-naturallyoccurring nucleic acids and/or non-naturally occurring nucleotidesand/or nucleotide analogs, and/or chemically modifications. Preferably,these non-naturally occurring nucleic acids and non-naturally occurringnucleotides are located outside the guide sequence. Non-naturallyoccurring nucleic acids can include, for example, mixtures of naturallyand non-naturally occurring nucleotides. Non-naturally occurringnucleotides and/or nucleotide analogs may be modified at the ribose,phosphate, and/or base moiety. In an embodiment of the invention, aguide nucleic acid comprises ribonucleotides and non-ribonucleotides. Inone such embodiment, a guide comprises one or more ribonucleotides andone or more deoxyribonucleotides. In an embodiment of the invention, theguide comprises one or more non-naturally occurring nucleotide ornucleotide analog such as a nucleotide with phosphorothioate linkage, alocked nucleic acid (LNA) nucleotides comprising a methylene bridgebetween the 2d/or non-naturally occurring nucleotides and/or nucleotideanalogs, and/or chemically modifications. Preferably, thesenon-naturally occurring nucleic acids and nouoro analogs. Furtherexamples of modified bases include, but are not limited to,2-aminopurine, 5-bromo-uridine, pseudouridine, inosine,7-methylguanosine. Examples of guide RNA chemical modifications include,without limitation, incorporation of 2ccurrinhyl (M), 2′-O-methyl3′phosphorothioate (MS), S-constrained ethyl(cEt), or 2ained ethyl(cEtxamples of guide RNA chemical modifications include, withoutlimitation, incorporation of 2ccurrinhyl (M), 2′-O-methyl3′phosphorothioate (MS), r chemically modificauides, though on-targetvs. off-target specificity is not predictable. (See, Hendel, 2015, NatBiotechnol. 33(9):985-9, doi: 10.1038/nbt.3290, published online 29 Jun.2015 Ragdarm et al., 0215, PNAS, E7110-E7111; Allerson et al., J. MedChem. 2005, 48:901-904; Bramsen et al., Front. Genet., 2012, 3:154; Denget al., PNAS, 2015, 112:11870-11875; Sharma et al., Med Chem Comm.,2014, 5:1454-1471; Hendel et al., Nat. Biotechnol. (2015) 33(9):985-989; Li et al., Nature Biomedical Engineering, 2017, 1, 0066DOI:10.1038/s41551-017-0066). In some embodiments, the 5′ and/or 3′ endof a guide RNA is modified by a variety of functional moieties includingfluorescent dyes, polyethylene glycol, cholesterol, proteins, ordetection tags. (See Kelly et al., 2016, J. Biotech. 233:74-83). Incertain embodiments, a guide comprises ribonucleotides in a region thatbinds to a target RNA and one or more deoxyribonucletides and/ornucleotide analogs in a region that binds to Cas13. In an embodiment ofthe invention, deoxyribonucleotides and/or nucleotide analogs areincorporated in engineered guide structures, such as, withoutlimitation, stem-loop regions, and the seed region. For Cas13 guide, incertain embodiments, the modification is not in the 5′-handle of thestem-loop regions. Chemical modification in the 5′-handle of thestem-loop region of a guide may abolish its function (see Li, et al.,Nature Biomedical Engineering, 2017, 1:0066). In certain embodiments, atleast 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19,20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, or 75nucleotides of a guide is chemically modified. In some embodiments, 3-5nucleotides at either the 3′ or the 5′ end of a guide is chemicallymodified. In some embodiments, only minor modifications are introducedin the seed region, such as 2′-F modifications. In some embodiments,2′-F modification is introduced at the 3′ end of a guide. In certainembodiments, three to five nucleotides at the 5′ and/or the 3′ end ofthe guide are chemically modified with 2′-O-methyl (M), 2′-O-methyl 3′phosphorothioate (MS), S-constrained ethyl(cEt), or 2′-O-methyl 3′thioPACE (MSP). Such modification can enhance genome editing efficiency(see Hendel et al., Nat. Biotechnol. (2015) 33(9): 985-989). In certainembodiments, all of the phosphodiester bonds of a guide are substitutedwith phosphorothioates (PS) for enhancing levels of gene disruption. Incertain embodiments, more than five nucleotides at the 5′ and/or the 3′end of the guide are chemically modified with 2′-O-Me, 2′-F orS-constrained ethyl(cEt). Such chemically modified guide can mediateenhanced levels of gene disruption (see Ragdarm et al., 0215, PNAS,E7110-E7111). In an embodiment of the invention, a guide is modified tocomprise a chemical moiety at its 3′ and/or 5′ end. Such moietiesinclude, but are not limited to amine, azide, alkyne, thio,dibenzocyclooctyne (DBCO), or Rhodamine. In certain embodiment, thechemical moiety is conjugated to the guide by a linker, such as an alkylchain. In certain embodiments, the chemical moiety of the modified guidecan be used to attach the guide to another molecule, such as DNA, RNA,protein, or nanoparticles. Such chemically modified guide can be used toidentify or enrich cells generically edited by a CRISPR system (see Leeet al., eLife, 2017, 6:e25312, DOI:10.7554).

In some embodiments, the modification to the guide is a chemicalmodification, an insertion, a deletion or a split. In some embodiments,the chemical modification includes, but is not limited to, incorporationof 2′-O-methyl (M) analogs, 2′-deoxy analogs, 2-thiouridine analogs,N6-methyladenosine analogs, 2′-fluoro analogs, 2-aminopurine,5-bromo-uridine, pseudouridine (Ψ), N1-methylpseudouridine (me1Ψ),5-methoxyuridine (5moU), inosine, 7-methylguanosine, 2′-O-methyl3′phosphorothioate (MS), S-constrained ethyl(cEt), phosphorothioate(PS), or 2′-O-methyl 3′thioPACE (MSP). In some embodiments, the guidecomprises one or more of phosphorothioate modifications. In certainembodiments, at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,16, 17, 18, 19, 20, or 25 nucleotides of the guide are chemicallymodified. In certain embodiments, one or more nucleotides in the seedregion are chemically modified. In certain embodiments, one or morenucleotides in the 3′-terminus are chemically modified. In certainembodiments, none of the nucleotides in the 5′-handle is chemicallymodified. In some embodiments, the chemical modification in the seedregion is a minor modification, such as incorporation of a 2′-fluoroanalog. In a specific embodiment, one nucleotide of the seed region isreplaced with a 2′-fluoro analog. In some embodiments, 5 to 10nucleotides in the 3′-terminus are chemically modified. Such chemicalmodifications at the 3′-terminus of the Cas13 CrRNA may improve Cas13activity. In a specific embodiment, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10nucleotides in the 3′-terminus are replaced with 2′-fluoro analogues. Ina specific embodiment, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 nucleotides inthe 3′-terminus are replaced with 2′-O-methyl (M) analogs.

In some embodiments, the loop of the 5′-handle of the guide is modified.In some embodiments, the loop of the 5′-handle of the guide is modifiedto have a deletion, an insertion, a split, or chemical modifications. Incertain embodiments, the modified loop comprises 3, 4, or 5 nucleotides.In certain embodiments, the loop comprises the sequence of UCUU, UUUU,UAUU, or UGUU.

In some embodiments, the guide molecule forms a stemloop with a separatenon-covalently linked sequence, which can be DNA or RNA. In particularembodiments, the sequences forming the guide are first synthesized usingthe standard phosphoramidite synthetic protocol (Herdewijn, P., ed.,Methods in Molecular Biology Col 288, Oligonucleotide Synthesis: Methodsand Applications, Humana Press, New Jersey (2012)). In some embodiments,these sequences can be functionalized to contain an appropriatefunctional group for ligation using the standard protocol known in theart (Hermanson, G. T., Bioconjugate Techniques, Academic Press (2013)).Examples of functional groups include, but are not limited to, hydroxyl,amine, carboxylic acid, carboxylic acid halide, carboxylic acid activeester, aldehyde, carbonyl, chlorocarbonyl, imidazolylcarbonyl,hydrozide, semicarbazide, thio semicarbazide, thiol, maleimide,haloalkyl, sufonyl, ally, propargyl, diene, alkyne, and azide. Once thissequence is functionalized, a covalent chemical bond or linkage can beformed between this sequence and the direct repeat sequence. Examples ofchemical bonds include, but are not limited to, those based oncarbamates, ethers, esters, amides, imines, amidines, aminotrizines,hydrozone, disulfides, thioethers, thioesters, phosphorothioates,phosphorodithioates, sulfonamides, sulfonates, fulfones, sulfoxides,ureas, thioureas, hydrazide, oxime, triazole, photolabile linkages, C—Cbond forming groups such as Diels-Alder cyclo-addition pairs orring-closing metathesis pairs, and Michael reaction pairs.

In some embodiments, these stem-loop forming sequences can be chemicallysynthesized. In some embodiments, the chemical synthesis uses automated,solid-phase oligonucleotide synthesis machines with 2′-acetoxyethylorthoester (2′-ACE) (Scaringe et al., J. Am. Chem. Soc. (1998) 120:11820-11821; Scaringe, Methods Enzymol. (2000) 317: 3-18) or2′-thionocarbamate (2′-TC) chemistry (Dellinger et al., J. Am. Chem.Soc. (2011) 133: 11540-11546; Hendel et al., Nat. Biotechnol. (2015)33:985-989).

In certain embodiments, the guide molecule comprises (1) a guidesequence capable of hybridizing to a target locus and (2) a tracr mateor direct repeat sequence whereby the direct repeat sequence is locatedupstream (i.e., 5′) from the guide sequence. In a particular embodimentthe seed sequence (i.e. the sequence essential critical for recognitionand/or hybridization to the sequence at the target locus) of th guidesequence is approximately within the first 10 nucleotides of the guidesequence.

In a particular embodiment the guide molecule comprises a guide sequencelinked to a direct repeat sequence, wherein the direct repeat sequencecomprises one or more stem loops or optimized secondary structures. Inparticular embodiments, the direct repeat has a minimum length of 16 ntsand a single stem loop. In further embodiments the direct repeat has alength longer than 16 nts, preferably more than 17 nts, and has morethan one stem loops or optimized secondary structures. In particularembodiments the guide molecule comprises or consists of the guidesequence linked to all or part of the natural direct repeat sequence. Atypical Type V or Type VI CRISPR-cas guide molecule comprises (in 3′ to5′ direction or in 5′ to 3′ direction): a guide sequence a firstcomplimentary stretch (the “repeat”), a loop (which is typically 4 or 5nucleotides long), a second complimentary stretch (the “anti-repeat”being complimentary to the repeat), and a poly A (often poly U in RNA)tail (terminator). In certain embodiments, the direct repeat sequenceretains its natural architecture and forms a single stem loop. Inparticular embodiments, certain aspects of the guide architecture can bemodified, for example by addition, subtraction, or substitution offeatures, whereas certain other aspects of guide architecture aremaintained. Preferred locations for engineered guide moleculemodifications, including but not limited to insertions, deletions, andsubstitutions include guide termini and regions of the guide moleculethat are exposed when complexed with the CRISPR-Cas protein and/ortarget, for example the stemloop of the direct repeat sequence.

In particular embodiments, the stem comprises at least about 4 bpcomprising complementary X and Y sequences, although stems of more,e.g., 5, 6, 7, 8, 9, 10, 11 or 12 or fewer, e.g., 3, 2, base pairs arealso contemplated. Thus, for example X2-10 and Y2-10 (wherein X and Yrepresent any complementary set of nucleotides) may be contemplated. Inone aspect, the stem made of the X and Y nucleotides, together with theloop will form a complete hairpin in the overall secondary structure;and, this may be advantageous and the amount of base pairs can be anyamount that forms a complete hairpin. In one aspect, any complementaryX:Y basepairing sequence (e.g., as to length) is tolerated, so long asthe secondary structure of the entire guide molecule is preserved. Inone aspect, the loop that connects the stem made of X:Y basepairs can beany sequence of the same length (e.g., 4 or 5 nucleotides) or longerthat does not interrupt the overall secondary structure of the guidemolecule. In one aspect, the stemloop can further comprise, e.g. an MS2aptamer. In one aspect, the stem comprises about 5-7 bp comprisingcomplementary X and Y sequences, although stems of more or fewerbasepairs are also contemplated. In one aspect, non-Watson Crickbasepairing is contemplated, where such pairing otherwise generallypreserves the architecture of the stemloop at that position.

In particular embodiments the natural hairpin or stemloop structure ofthe guide molecule is extended or replaced by an extended stemloop. Ithas been demonstrated that extension of the stem can enhance theassembly of the guide molecule with the CRISPR-Cas protein (Chen et al.Cell. (2013); 155(7): 1479-1491). In particular embodiments the stem ofthe stemloop is extended by at least 1, 2, 3, 4, 5 or more complementarybasepairs (i.e. corresponding to the addition of 2, 4, 6, 8, 10 or morenucleotides in the guide molecule). In particular embodiments these arelocated at the end of the stem, adjacent to the loop of the stemloop.

In particular embodiments, the susceptibility of the guide molecule toRNAses or to decreased expression can be reduced by slight modificationsof the sequence of the guide molecule which do not affect its function.For instance, in particular embodiments, premature termination oftranscription, such as premature transcription of U6 Pol-III, can beremoved by modifying a putative Pol-III terminator (4 consecutive U's)in the guide molecules sequence. Where such sequence modification isrequired in the stemloop of the guide molecule, it is preferably ensuredby a basepair flip.

In a particular embodiment, the direct repeat may be modified tocomprise one or more protein-binding RNA aptamers. In a particularembodiment, one or more aptamers may be included such as part ofoptimized secondary structure. Such aptamers may be capable of binding abacteriophage coat protein as detailed further herein.

In some embodiments, the guide molecule forms a duplex with a target RNAcomprising at least one target cytosine residue to be edited. Uponhybridization of the guide RNA molecule to the target RNA, the cytidinedeaminase binds to the single strand RNA in the duplex made accessibleby the mismatch in the guide sequence and catalyzes deamination of oneor more target cytosine residues comprised within the stretch ofmismatching nucleotides.

A guide sequence, and hence a nucleic acid-targeting guide RNA may beselected to target any target nucleic acid sequence. The target sequencemay be mRNA.

In certain embodiments, the target sequence should be associated with aPAM (protospacer adjacent motif) or PFS (protospacer flanking sequenceor site); that is, a short sequence recognized by the CRISPR complex.Depending on the nature of the CRISPR-Cas protein, the target sequenceshould be selected such that its complementary sequence in the DNAduplex (also referred to herein as the non-target sequence) is upstreamor downstream of the PAM. In the embodiments of the present inventionwhere the CRISPR-Cas protein is a Cas13 protein, the compelementarysequence of the target sequence is downstream or 3′ of the PAM orupstream or 5′ of the PAM. The precise sequence and length requirementsfor the PAM differ depending on the Cas13 protein used, but PAMs aretypically 2-5 base pair sequences adjacent the protospacer (that is, thetarget sequence). Examples of the natural PAM sequences for differentCas13 orthologues are provided herein below and the skilled person willbe able to identify further PAM sequences for use with a given Cas13protein.

Further, engineering of the PAM Interacting (PI) domain may allowprograming of PAM specificity, improve target site recognition fidelity,and increase the versatility of the CRISPR-Cas protein, for example asdescribed for Cas9 in Kleinstiver B P et al. Engineered CRISPR-Cas9nucleases with altered PAM specificities. Nature. 2015 Jul. 23;523(7561):481-5. doi: 10.1038/nature14592. As further detailed herein,the skilled person will understand that Cas13 proteins may be modifiedanalogously.

In particular embodiment, the guide is an escorted guide. By “escorted”is meant that the CRISPR-Cas system or complex or guide is delivered toa selected time or place within a cell, so that activity of theCRISPR-Cas system or complex or guide is spatially or temporallycontrolled. For example, the activity and destination of the 3CRISPR-Cas system or complex or guide may be controlled by an escort RNAaptamer sequence that has binding affinity for an aptamer ligand, suchas a cell surface protein or other localized cellular component.Alternatively, the escort aptamer may for example be responsive to anaptamer effector on or in the cell, such as a transient effector, suchas an external energy source that is applied to the cell at a particulartime.

The escorted CRISPR-Cas systems or complexes have a guide molecule witha functional structure designed to improve guide molecule structure,architecture, stability, genetic expression, or any combination thereof.Such a structure can include an aptamer.

Aptamers are biomolecules that can be designed or selected to bindtightly to other ligands, for example using a technique calledsystematic evolution of ligands by exponential enrichment (SELEX; TuerkC, Gold L: “Systematic evolution of ligands by exponential enrichment:RNA ligands to bacteriophage T4 DNA polymerase.” Science 1990,249:505-510). Nucleic acid aptamers can for example be selected frompools of random-sequence oligonucleotides, with high binding affinitiesand specificities for a wide range of biomedically relevant targets,suggesting a wide range of therapeutic utilities for aptamers (Keefe,Anthony D., Supriya Pai, and Andrew Ellington. “Aptamers astherapeutics.” Nature Reviews Drug Discovery 9.7 (2010): 537-550). Thesecharacteristics also suggest a wide range of uses for aptamers as drugdelivery vehicles (Levy-Nissenbaum, Etgar, et al. “Nanotechnology andaptamers: applications in drug delivery.” Trends in biotechnology 26.8(2008): 442-449; and, Hicke B J, Stephens A W. “Escort aptamers: adelivery service for diagnosis and therapy.” J Clin Invest 2000,106:923-928.). Aptamers may also be constructed that function asmolecular switches, responding to a que by changing properties, such asRNA aptamers that bind fluorophores to mimic the activity of greenflourescent protein (Paige, Jeremy S., Karen Y. Wu, and Samie R.Jaffrey. “RNA mimics of green fluorescent protein.” Science 333.6042(2011): 642-646). It has also been suggested that aptamers may be usedas components of targeted siRNA therapeutic delivery systems, forexample targeting cell surface proteins (Zhou, Jiehua, and John J.Rossi. “Aptamer-targeted cell-specific RNA interference.” Silence 1.1(2010): 4).

Accordingly, in particular embodiments, the guide molecule is modified,e.g., by one or more aptamer(s) designed to improve guide moleculedelivery, including delivery across the cellular membrane, tointracellular compartments, or into the nucleus. Such a structure caninclude, either in addition to the one or more aptamer(s) or withoutsuch one or more aptamer(s), moiety(ies) so as to render the guidemolecule deliverable, inducible or responsive to a selected effector.The invention accordingly comprehends an guide molecule that responds tonormal or pathological physiological conditions, including withoutlimitation pH, hypoxia, O₂ concentration, temperature, proteinconcentration, enzymatic concentration, lipid structure, light exposure,mechanical disruption (e.g. ultrasound waves), magnetic fields, electricfields, or electromagnetic radiation.

Light responsiveness of an inducible system may be achieved via theactivation and binding of cryptochrome-2 and CIB1. Blue lightstimulation induces an activating conformational change incryptochrome-2, resulting in recruitment of its binding partner CIB1.This binding is fast and reversible, achieving saturation in <15 secfollowing pulsed stimulation and returning to baseline <15 min after theend of stimulation. These rapid binding kinetics result in a systemtemporally bound only by the speed of transcription/translation andtranscript/protein degradation, rather than uptake and clearance ofinducing agents. Crytochrome-2 activation is also highly sensitive,allowing for the use of low light intensity stimulation and mitigatingthe risks of phototoxicity. Further, in a context such as the intactmammalian brain, variable light intensity may be used to control thesize of a stimulated region, allowing for greater precision than vectordelivery alone may offer.

The invention contemplates energy sources such as electromagneticradiation, sound energy or thermal energy to induce the guide.Advantageously, the electromagnetic radiation is a component of visiblelight. In a preferred embodiment, the light is a blue light with awavelength of about 450 to about 495 nm. In an especially preferredembodiment, the wavelength is about 488 nm. In another preferredembodiment, the light stimulation is via pulses. The light power mayrange from about 0-9 mW/cm². In a preferred embodiment, a stimulationparadigm of as low as 0.25 sec every 15 sec should result in maximalactivation.

The chemical or energy sensitive guide may undergo a conformationalchange upon induction by the binding of a chemical source or by theenergy allowing it act as a guide and have the Cas13 CRISPR-Cas systemor complex function. The invention can involve applying the chemicalsource or energy so as to have the guide function and the Cas13CRISPR-Cas system or complex function; and optionally furtherdetermining that the expression of the genomic locus is altered.

There are several different designs of this chemical induciblesystem: 1. ABI-PYL based system inducible by Abscisic Acid (ABA) (see,e.g., stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/rs2), 2.FKBP-FRB based system inducible by rapamycin (or related chemicals basedon rapamycin) (see, e.g.,www.nature.com/nmeth/journal/v2/n6/full/nmeth763.html), 3. GID1-GAIbased system inducible by Gibberellin (GA) (see, e.g.,www.nature.com/nchembio/journal/v8/n5/full/nchembio.922.html).

A chemical inducible system can be an estrogen receptor (ER) basedsystem inducible by 4-hydroxytamoxifen (40HT) (see, e.g.,www.pnas.org/content/104/3/1027.abstract). A mutated ligand-bindingdomain of the estrogen receptor called ERT2 translocates into thenucleus of cells upon binding of 4-hydroxytamoxifen. In furtherembodiments of the invention any naturally occurring or engineeredderivative of any nuclear receptor, thyroid hormone receptor, retinoicacid receptor, estrogren receptor, estrogen-related receptor,glucocorticoid receptor, progesterone receptor, androgen receptor may beused in inducible systems analogous to the ER based inducible system.

Another inducible system is based on the design using Transient receptorpotential (TRP) ion channel based system inducible by energy, heat orradio-wave (see, e.g., www.sciencemag.org/content/336/6081/604). TheseTRP family proteins respond to different stimuli, including light andheat. When this protein is activated by light or heat, the ion channelwill open and allow the entering of ions such as calcium into the plasmamembrane. This influx of ions will bind to intracellular ion interactingpartners linked to a polypeptide including the guide and the othercomponents of the Cas13 CRISPR-Cas complex or system, and the bindingwill induce the change of sub-cellular localization of the polypeptide,leading to the entire polypeptide entering the nucleus of cells. Onceinside the nucleus, the guide protein and the other components of theCas13 CRISPR-Cas complex will be active and modulating target geneexpression in cells.

While light activation may be an advantageous embodiment, sometimes itmay be disadvantageous especially for in vivo applications in which thelight may not penetrate the skin or other organs. In this instance,other methods of energy activation are contemplated, in particular,electric field energy and/or ultrasound which have a similar effect.

Electric field energy is preferably administered substantially asdescribed in the art, using one or more electric pulses of from about 1Volt/cm to about 10 kVolts/cm under in vivo conditions. Instead of or inaddition to the pulses, the electric field may be delivered in acontinuous manner. The electric pulse may be applied for between 1 μsand 500 milliseconds, preferably between 1 μs and 100 milliseconds. Theelectric field may be applied continuously or in a pulsed manner for 5about minutes.

As used herein, ‘electric field energy’ is the electrical energy towhich a cell is exposed. Preferably the electric field has a strength offrom about 1 Volt/cm to about 10 kVolts/cm or more under in vivoconditions (see WO97/49450).

As used herein, the term “electric field” includes one or more pulses atvariable capacitance and voltage and including exponential and/or squarewave and/or modulated wave and/or modulated square wave forms.References to electric fields and electricity should be taken to includereference the presence of an electric potential difference in theenvironment of a cell. Such an environment may be set up by way ofstatic electricity, alternating current (AC), direct current (DC), etc,as known in the art. The electric field may be uniform, non-uniform orotherwise, and may vary in strength and/or direction in a time dependentmanner.

Single or multiple applications of electric field, as well as single ormultiple applications of ultrasound are also possible, in any order andin any combination. The ultrasound and/or the electric field may bedelivered as single or multiple continuous applications, or as pulses(pulsatile delivery).

Electroporation has been used in both in vitro and in vivo procedures tointroduce foreign material into living cells. With in vitroapplications, a sample of live cells is first mixed with the agent ofinterest and placed between electrodes such as parallel plates. Then,the electrodes apply an electrical field to the cell/implant mixture.Examples of systems that perform in vitro electroporation include theElectro Cell Manipulator ECM600 product, and the Electro Square PoratorT820, both made by the BTX Division of Genetronics, Inc (see U.S. Pat.No. 5,869,326).

The known electroporation techniques (both in vitro and in vivo)function by applying a brief high voltage pulse to electrodes positionedaround the treatment region. The electric field generated between theelectrodes causes the cell membranes to temporarily become porous,whereupon molecules of the agent of interest enter the cells. In knownelectroporation applications, this electric field comprises a singlesquare wave pulse on the order of 1000 V/cm, of about 100 .mu.sduration. Such a pulse may be generated, for example, in knownapplications of the Electro Square Porator T820.

Preferably, the electric field has a strength of from about 1 V/cm toabout 10 kV/cm under in vitro conditions. Thus, the electric field mayhave a strength of 1 V/cm, 2 V/cm, 3 V/cm, 4 V/cm, 5 V/cm, 6 V/cm, 7V/cm, 8 V/cm, 9 V/cm, 10 V/cm, 20 V/cm, 50 V/cm, 100 V/cm, 200 V/cm, 300V/cm, 400 V/cm, 500 V/cm, 600 V/cm, 700 V/cm, 800 V/cm, 900 V/cm, 1kV/cm, 2 kV/cm, 5 kV/cm, 10 kV/cm, 20 kV/cm, 50 kV/cm or more. Morepreferably from about 0.5 kV/cm to about 4.0 kV/cm under in vitroconditions. Preferably the electric field has a strength of from about 1V/cm to about 10 kV/cm under in vivo conditions. However, the electricfield strengths may be lowered where the number of pulses delivered tothe target site are increased. Thus, pulsatile delivery of electricfields at lower field strengths is envisaged.

Preferably the application of the electric field is in the form ofmultiple pulses such as double pulses of the same strength andcapacitance or sequential pulses of varying strength and/or capacitance.As used herein, the term “pulse” includes one or more electric pulses atvariable capacitance and voltage and including exponential and/or squarewave and/or modulated wave/square wave forms.

Preferably the electric pulse is delivered as a waveform selected froman exponential wave form, a square wave form, a modulated wave form anda modulated square wave form.

A preferred embodiment employs direct current at low voltage. Thus,Applicants disclose the use of an electric field which is applied to thecell, tissue or tissue mass at a field strength of between 1V/cm and20V/cm, for a period of 100 milliseconds or more, preferably 15 minutesor more.

Ultrasound is advantageously administered at a power level of from about0.05 W/cm2 to about 100 W/cm2. Diagnostic or therapeutic ultrasound maybe used, or combinations thereof.

As used herein, the term “ultrasound” refers to a form of energy whichconsists of mechanical vibrations the frequencies of which are so highthey are above the range of human hearing. Lower frequency limit of theultrasonic spectrum may generally be taken as about 20 kHz. Mostdiagnostic applications of ultrasound employ frequencies in the range 1and 15 MHz′ (From Ultrasonics in Clinical Diagnosis, P. N. T. Wells,ed., 2nd. Edition, Publ. Churchill Livingstone [Edinburgh, London & NY,1977]).

Ultrasound has been used in both diagnostic and therapeuticapplications. When used as a diagnostic tool (“diagnostic ultrasound”),ultrasound is typically used in an energy density range of up to about100 mW/cm2 (FDA recommendation), although energy densities of up to 750mW/cm2 have been used. In physiotherapy, ultrasound is typically used asan energy source in a range up to about 3 to 4 W/cm2 (WHOrecommendation). In other therapeutic applications, higher intensitiesof ultrasound may be employed, for example, HIFU at 100 W/cm up to 1kW/cm2 (or even higher) for short periods of time. The term “ultrasound”as used in this specification is intended to encompass diagnostic,therapeutic and focused ultrasound.

Focused ultrasound (FUS) allows thermal energy to be delivered withoutan invasive probe (see Morocz et al 1998 Journal of Magnetic ResonanceImaging Vol. 8, No. 1, pp. 136-142. Another form of focused ultrasoundis high intensity focused ultrasound (HIFU) which is reviewed byMoussatov et al in Ultrasonics (1998) Vol. 36, No. 8, pp. 893-900 andTranHuuHue et al in Acustica (1997) Vol. 83, No. 6, pp. 1103-1106.

Preferably, a combination of diagnostic ultrasound and a therapeuticultrasound is employed. This combination is not intended to be limiting,however, and the skilled reader will appreciate that any variety ofcombinations of ultrasound may be used. Additionally, the energydensity, frequency of ultrasound, and period of exposure may be varied.

Preferably the exposure to an ultrasound energy source is at a powerdensity of from about 0.05 to about 100 Wcm-2. Even more preferably, theexposure to an ultrasound energy source is at a power density of fromabout 1 to about 15 Wcm-2.

Preferably the exposure to an ultrasound energy source is at a frequencyof from about 0.015 to about 10.0 MHz. More preferably the exposure toan ultrasound energy source is at a frequency of from about 0.02 toabout 5.0 MHz or about 6.0 MHz. Most preferably, the ultrasound isapplied at a frequency of 3 MHz.

Preferably the exposure is for periods of from about 10 milliseconds toabout 60 minutes. Preferably the exposure is for periods of from about 1second to about 5 minutes. More preferably, the ultrasound is appliedfor about 2 minutes. Depending on the particular target cell to bedisrupted, however, the exposure may be for a longer duration, forexample, for 15 minutes.

Advantageously, the target tissue is exposed to an ultrasound energysource at an acoustic power density of from about 0.05 Wcm-2 to about 10Wcm-2 with a frequency ranging from about 0.015 to about 10 MHz (see WO98/52609). However, alternatives are also possible, for example,exposure to an ultrasound energy source at an acoustic power density ofabove 100 Wcm-2, but for reduced periods of time, for example, 1000Wcm-2 for periods in the millisecond range or less.

Preferably the application of the ultrasound is in the form of multiplepulses; thus, both continuous wave and pulsed wave (pulsatile deliveryof ultrasound) may be employed in any combination. For example,continuous wave ultrasound may be applied, followed by pulsed waveultrasound, or vice versa. This may be repeated any number of times, inany order and combination. The pulsed wave ultrasound may be appliedagainst a background of continuous wave ultrasound, and any number ofpulses may be used in any number of groups.

Preferably, the ultrasound may comprise pulsed wave ultrasound. In ahighly preferred embodiment, the ultrasound is applied at a powerdensity of 0.7 Wcm-2 or 1.25 Wcm-2 as a continuous wave. Higher powerdensities may be employed if pulsed wave ultrasound is used.

Use of ultrasound is advantageous as, like light, it may be focusedaccurately on a target. Moreover, ultrasound is advantageous as it maybe focused more deeply into tissues unlike light. It is therefore bettersuited to whole-tissue penetration (such as but not limited to a lobe ofthe liver) or whole organ (such as but not limited to the entire liveror an entire muscle, such as the heart) therapy. Another importantadvantage is that ultrasound is a non-invasive stimulus which is used ina wide variety of diagnostic and therapeutic applications. By way ofexample, ultrasound is well known in medical imaging techniques and,additionally, in orthopedic therapy. Furthermore, instruments suitablefor the application of ultrasound to a subject vertebrate are widelyavailable and their use is well known in the art.

In particular embodiments, the guide molecule is modified by a secondarystructure to increase the specificity of the CRISPR-Cas system and thesecondary structure can protect against exonuclease activity and allowfor 5′ additions to the guide sequence also referred to herein as aprotected guide molecule.

In one aspect, the invention provides for hybridizing a “protector RNA”to a sequence of the guide molecule, wherein the “protector RNA” is anRNA strand complementary to the 3′ end of the guide molecule to therebygenerate a partially double-stranded guide RNA. In an embodiment of theinvention, protecting mismatched bases (i.e. the bases of the guidemolecule which do not form part of the guide sequence) with a perfectlycomplementary protector sequence decreases the likelihood of target RNAbinding to the mismatched basepairs at the 3′ end. In particularembodiments of the invention, additional sequences comprising anextented length may also be present within the guide molecule such thatthe guide comprises a protector sequence within the guide molecule. This“protector sequence” ensures that the guide molecule comprises a“protected sequence” in addition to an “exposed sequence” (comprisingthe part of the guide sequence hybridizing to the target sequence). Inparticular embodiments, the guide molecule is modified by the presenceof the protector guide to comprise a secondary structure such as ahairpin. Advantageously there are three or four to thirty or more, e.g.,about 10 or more, contiguous base pairs having complementarity to theprotected sequence, the guide sequence or both. It is advantageous thatthe protected portion does not impede thermodynamics of the CRISPR-Cassystem interacting with its target. By providing such an extensionincluding a partially double stranded guide molecule, the guide moleculeis considered protected and results in improved specific binding of theCRISPR-Cas complex, while maintaining specific activity.

In particular embodiments, use is made of a truncated guide (tru-guide),i.e. a guide molecule which comprises a guide sequence which istruncated in length with respect to the canonical guide sequence length.As described by Nowak et al. (Nucleic Acids Res (2016) 44 (20):9555-9564), such guides may allow catalytically active CRISPR-Cas enzymeto bind its target without cleaving the target RNA. In particularembodiments, a truncated guide is used which allows the binding of thetarget but retains only nickase activity of the CRISPR-Cas enzyme.

CRISPR RNA-Targeting Effector Proteins

In one example embodiment, the CRISPR system effector protein is anRNA-targeting effector protein. In certain embodiments, the CRISPRsystem effector protein is a Type VI CRISPR system targeting RNA (e.g.,Cas13a, Cas13b, Cas13c or Cas13d). Example RNA-targeting effectorproteins include Cas13b and C2c2 (now known as Cas13a). It will beunderstood that the term “C2c2” herein is used interchangeably with“Cas13a”. “C2c2” is now referred to as “Cas13a”, and the terms are usedinterchangeably herein unless indicated otherwise. As used herein, theterm “Cas13” refers to any Type VI CRISPR system targeting RNA (e.g.,Cas13a, Cas13b, Cas13c or Cas13d). When the CRISPR protein is a C2c2protein, a tracrRNA is not required. C2c2 has been described inAbudayyeh et al. (2016) “C2c2 is a single-component programmableRNA-guided RNA-targeting CRISPR effector”; Science; DOI:10.1126/science.aaf5573; and Shmakov et al. (2015) “Discovery andFunctional Characterization of Diverse Class 2 CRISPR-Cas Systems”,Molecular Cell, DOI: dx.doi.org/10.1016/j.molcel.2015.10.008; which areincorporated herein in their entirety by reference. Cas13b has beendescribed in Smargon et al. (2017) “Cas13b Is a Type VI-BCRISPR-Associated RNA-Guided RNases Differentially Regulated byAccessory Proteins Csx27 and Csx28,” Molecular Cell. 65, 1-13;dx.doi.org/10.1016/j.molcel.2016.12.023., which is incorporated hereinin its entirety by reference.

In some embodiments, one or more elements of a nucleic acid-targetingsystem is derived from a particular organism comprising an endogenousCRISPR RNA-targeting system. In certain example embodiments, theeffector protein CRISPR RNA-targeting system comprises at least one HEPNdomain, including but not limited to the HEPN domains described herein,HEPN domains known in the art, and domains recognized to be HEPN domainsby comparison to consensus sequence motifs. Several such domains areprovided herein. In one non-limiting example, a consensus sequence canbe derived from the sequences of C2c2 or Cas13b orthologs providedherein. In certain example embodiments, the effector protein comprises asingle HEPN domain. In certain other example embodiments, the effectorprotein comprises two HEPN domains.

In one example embodiment, the effector protein comprise one or moreHEPN domains comprising a RxxxxH motif sequence. The RxxxxH motifsequence can be, without limitation, from a HEPN domain described hereinor a HEPN domain known in the art. RxxxxH motif sequences furtherinclude motif sequences created by combining portions of two or moreHEPN domains. As noted, consensus sequences can be derived from thesequences of the orthologs disclosed in U.S. Provisional PatentApplication 62/432,240 entitled “Novel CRISPR Enzymes and Systems,” U.S.Provisional Patent Application 62/471,710 entitled “Novel Type VI CRISPROrthologs and Systems” filed on Mar. 15, 2017, and U.S. ProvisionalPatent Application entitled “Novel Type VI CRISPR Orthologs andSystems,” labeled as attorney docket number 47627-05-2133 and filed onApr. 12, 2017.

In certain other example embodiments, the CRISPR system effector proteinis a C2c2 nuclease (also referred to as Cas13a). The activity of C2c2may depend on the presence of two HEPN domains. These have been shown tobe RNase domains, i.e. nuclease (in particular an endonuclease) cuttingRNA. C2c2 HEPN may also target DNA, or potentially DNA and/or RNA. Onthe basis that the HEPN domains of C2c2 are at least capable of bindingto and, in their wild-type form, cutting RNA, then it is preferred thatthe C2c2 effector protein has RNase function. Regarding C2c2 CRISPRsystems, reference is made to U.S. Provisional 62/351,662 filed on Jun.17, 2016 and U.S. Provisional 62/376,377 filed on Aug. 17, 2016.Reference is also made to U.S. Provisional 62/351,803 filed on Jun. 17,2016. Reference is also made to U.S. Provisional entitled “Novel CrisprEnzymes and Systems” filed Dec. 8, 2016 bearing Broad Institute No.10035.PA4 and Attorney Docket No. 47627.03.2133. Reference is furthermade to East-Seletsky et al. “Two distinct RNase activities ofCRISPR-C2c2 enable guide-RNA processing and RNA detection” Naturedoi:10/1038/nature19802 and Abudayyeh et al. “C2c2 is a single-componentprogrammable RNA-guided RNA targeting CRISPR effector” bioRxivdoi:10.1101/054742.

In certain embodiments, the C2c2 effector protein is from an organism ofa genus selected from the group consisting of: Leptotrichia, Listeria,Corynebacterium, Sutterella, Legionella, Treponema, Filifactor,Eubacterium, Streptococcus, Lactobacillus, Mycoplasma, Bacteroides,Flaviivola, Flavobacterium, Sphaerochaeta, Azospirillum,Gluconacetobacter, Neisseria, Roseburia, Parvibaculum, Staphylococcus,Nitratifractor, Mycoplasma, Campylobacter, and Lachnospira, or the C2c2effector protein is an organism selected from the group consisting of:Leptotrichia shahii, Leptotrichia. wadei, Listeria seeligeri,Clostridium aminophilum, Carnobacterium gallinarum, Paludibacterpropionicigenes, Listeria weihenstephanensis, or the C2c2 effectorprotein is a L. wadei F0279 or L. wadei F0279 (Lw2) C2C2 effectorprotein. In another embodiment, the one or more guide RNAs are designedto detect a single nucleotide polymorphism, splice variant of atranscript, or a frameshift mutation in a target RNA or DNA.

In certain example embodiments, the RNA-targeting effector protein is aType VI-B effector protein, such as Cas13b and Group 29 or Group 30proteins. In certain example embodiments, the RNA-targeting effectorprotein comprises one or more HEPN domains. In certain exampleembodiments, the RNA-targeting effector protein comprises a C-terminalHEPN domain, a N-terminal HEPN domain, or both. Regarding example TypeVI-B effector proteins that may be used in the context of thisinvention, reference is made to U.S. application Ser. No. 15/331,792entitled “Novel CRISPR Enzymes and Systems” and filed Oct. 21, 2016,International Patent Application No. PCT/US2016/058302 entitled “NovelCRISPR Enzymes and Systems”, and filed Oct. 21, 2016, and Smargon et al.“Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentiallyregulated by accessory proteins Csx27 and Csx28” Molecular Cell, 65,1-13 (2017); dx.doi.org/10.1016/j.molcel.2016.12.023, and U.S.Provisional Application No. to be assigned, entitled “Novel Cas13bOrthologues CRISPR Enzymes and System” filed Mar. 15, 2017. Inparticular embodiments, the Cas13b enzyme is derived from Bergeyellazoohelcum.

In certain example embodiments, the RNA-targeting effector protein is aCas13c effector protein as disclosed in U.S. Provisional PatentApplication No. 62/525,165 filed Jun. 26, 2017, and PCT Application No.US 2017/047193 filed Aug. 16, 2017.

In some embodiments, one or more elements of a nucleic acid-targetingsystem is derived from a particular organism comprising an endogenousCRISPR RNA-targeting system. In certain embodiments, the CRISPRRNA-targeting system is found in Eubacterium and Ruminococcus. Incertain embodiments, the effector protein comprises targeted andcollateral ssRNA cleavage activity. In certain embodiments, the effectorprotein comprises dual HEPN domains. In certain embodiments, theeffector protein lacks a counterpart to the Helical-1 domain of Cas13a.In certain embodiments, the effector protein is smaller than previouslycharacterized class 2 CRISPR effectors, with a median size of 928 aa.This median size is 190 aa (17%) less than that of Cas13c, more than 200aa (18%) less than that of Cas13b, and more than 300 aa (26%) less thanthat of Cas13a. In certain embodiments, the effector protein has norequirement for a flanking sequence (e.g., PFS, PAM).

In certain embodiments, the effector protein locus structures include aWYL domain containing accessory protein (so denoted after three aminoacids that were conserved in the originally identified group of thesedomains; see, e.g., WYL domain IPR026881). In certain embodiments, theWYL domain accessory protein comprises at least one helix-turn-helix(HTH) or ribbon-helix-helix (RHH) DNA-binding domain. In certainembodiments, the WYL domain containing accessory protein increases boththe targeted and the collateral ssRNA cleavage activity of theRNA-targeting effector protein. In certain embodiments, the WYL domaincontaining accessory protein comprises an N-terminal RHH domain, as wellas a pattern of primarily hydrophobic conserved residues, including aninvariant tyrosine-leucine doublet corresponding to the original WYLmotif. In certain embodiments, the WYL domain containing accessoryprotein is WYLL. WYL1 is a single WYL-domain protein associatedprimarily with Ruminococcus.

In other example embodiments, the Type VI RNA-targeting Cas enzyme isCas13d. In certain embodiments, Cas13d is Eubacterium siraeum DSM 15702(EsCas13d) or Ruminococcus sp. N15.MGS-57 (RspCas13d) (see, e.g., Yan etal., Cas13d Is a Compact RNA-Targeting Type VI CRISPR EffectorPositively Modulated by a WYL-Domain-Containing Accessory Protein,Molecular Cell (2018), doi.org/10.1016/j.molcel.2018.02.028). RspCas13dand EsCas13d have no flanking sequence requirements (e.g., PFS, PAM).

Cas13 RNA Editing

In one aspect, the invention provides a method of modifying or editing atarget transcript in a eukaryotic cell. In some embodiments, the methodcomprises allowing a CRISPR-Cas effector module complex to bind to thetarget polynucleotide to effect RNA base editing, wherein the CRISPR-Caseffector module complex comprises a Cas effector module complexed with aguide sequence hybridized to a target sequence within said targetpolynucleotide, wherein said guide sequence is linked to a direct repeatsequence. In some embodiments, the Cas effector module comprises acatalytically inactive CRISPR-Cas protein. In some embodiments, theguide sequence is designed to introduce one or more mismatches to theRNA/RNA duplex formed between the target sequence and the guidesequence. In particular embodiments, the mismatch is an A-C mismatch. Insome embodiments, the Cas effector may associate with one or morefunctional domains (e.g. via fusion protein or suitable linkers). Insome embodiments, the effector domain comprises one or more cytindine oradenosine deaminases that mediate endogenous editing of via hydrolyticdeamination. In particular embodiments, the effector domain comprisesthe adenosine deaminase acting on RNA (ADAR) family of enzymes. Inparticular embodiments, the adenosine deaminase protein or catalyticdomain thereof capable of deaminating adenosine or cytidine in RNA or isan RNA specific adenosine deaminase and/or is a bacterial, human,cephalopod, or Drosophila adenosine deaminase protein or catalyticdomain thereof, preferably TadA, more preferably ADAR, optionallyhuADAR, optionally (hu)ADAR1 or (hu)ADAR2, preferably huADAR2 orcatalytic domain thereof.

The present application relates to modifying a target RNA sequence ofinterest (see, e.g, Cox et al., Science. 2017 Nov. 24;358(6366):1019-1027). Using RNA-targeting rather than DNA targetingoffers several advantages relevant for therapeutic development. First,there are substantial safety benefits to targeting RNA: there will befewer off-target events because the available sequence space in thetranscriptome is significantly smaller than the genome, and if anoff-target event does occur, it will be transient and less likely toinduce negative side effects. Second, RNA-targeting therapeutics will bemore efficient because they are cell-type independent and not have toenter the nucleus, making them easier to deliver.

A further aspect of the invention relates to the method and compositionas envisaged herein for use in prophylactic or therapeutic treatment,preferably wherein said target locus of interest is within a human oranimal and to methods of modifying an Adenine or Cytidine in a targetRNA sequence of interest, comprising delivering to said target RNA, thecomposition as described herein. In particular embodiments, the CRISPRsystem and the adenonsine deaminase, or catalytic domain thereof, aredelivered as one or more polynucleotide molecules, as aribonucleoprotein complex, optionally via particles, vesicles, or one ormore viral vectors. In particular embodiments, the invention thuscomprises compositions for use in therapy. This implies that the methodscan be performed in vivo, ex vivo or in vitro. In particularembodiments, when the target is a human or animal target, the method iscarried out ex vivo or in vitro.

A further aspect of the invention relates to the method as envisagedherein for use in prophylactic or therapeutic treatment, preferablywherein said target of interest is within a human or animal and tomethods of modifying an Adenine or Cytidine in a target RNA sequence ofinterest, comprising delivering to said target RNA, the composition asdescribed herein. In particular embodiments, the CRISPR system and theadenonsine deaminase, or catalytic domain thereof, are delivered as oneor more polynucleotide molecules, as a ribonucleoprotein complex,optionally via particles, vesicles, or one or more viral vectors.

In one aspect, the invention provides a method of generating aeukaryotic cell comprising a modified or edited gene. In someembodiments, the method comprises (a) introducing one or more vectorsinto a eukaryotic cell, wherein the one or more vectors drive expressionof one or more of: Cas effector module, and a guide sequence linked to adirect repeat sequence, wherein the Cas effector module associate one ormore effector domains that mediate base editing, and (b) allowing aCRISPR-Cas effector module complex to bind to a target polynucleotide toeffect base editing of the target polynucleotide within said diseasegene, wherein the CRISPR-Cas effector module complex comprises a Caseffector module complexed with the guide sequence that is hybridized tothe target sequence within the target polynucleotide, wherein the guidesequence may be designed to introduce one or more mismatches between theRNA/RNA duplex formed between the guide sequence and the targetsequence. In particular embodiments, the mismatch is an A-C mismatch. Insome embodiments, the Cas effector may associate with one or morefunctional domains (e.g. via fusion protein or suitable linkers). Insome embodiments, the effector domain comprises one or more cytidine oradenosine deaminases that mediate endogenous editing of via hydrolyticdeamination. In particular embodiments, the effector domain comprisesthe adenosine deaminase acting on RNA (ADAR) family of enzymes. Inparticular embodiments, the adenosine deaminase protein or catalyticdomain thereof capable of deaminating adenosine or cytidine in RNA or isan RNA specific adenosine deaminase and/or is a bacterial, human,cephalopod, or Drosophila adenosine deaminase protein or catalyticdomain thereof, preferably TadA, more preferably ADAR, optionallyhuADAR, optionally (hu)ADAR1 or (hu)ADAR2, preferably huADAR2 orcatalytic domain thereof.

The present invention may also use a Cas12 CRISPR enzyme. Cas12 enzymesinclude Cas12a (Cpf1), Cas12b (C2c1), and Cas12c (C2c3), describedfurther herein. The Cas12 may be an ultraCas12. IDT developed a “Alt-RCas12a” reagent that has 3 main components: a) optimized crRNA; b) A.s.Cas12a; and (c) an electroporation enhancer (for better transfection).The variant is an improved version of IDT's Alt-R Cas12a and is named“Alt-R Cas12a Ultra.”

A further aspect relates to an isolated cell obtained or obtainable fromthe methods described herein comprising the composition described hereinor progeny of said modified cell, preferably wherein said cell comprisesa hypoxanthine or a guanine in replace of said Adenine in said targetRNA of interest compared to a corresponding cell not subjected to themethod. In particular embodiments, the cell is a eukaryotic cell,preferably a human or non-human animal cell, optionally a therapeutic Tcell or an antibody-producing B-cell.

In some embodiments, the modified cell is a therapeutic T cell, such asa T cell suitable for adoptive cell transfer therapies (e.g., CAR-Ttherapies). The modification may result in one or more desirable traitsin the therapeutic T cell, as described further herein.

The invention further relates to a method for cell therapy, comprisingadministering to a patient in need thereof the modified cell describedherein, wherein the presence of the modified cell remedies a disease inthe patient.

The present invention may be further illustrated and extended based onaspects of CRISPR-Cas development and use as set forth in the followingarticles and particularly as relates to delivery of a CRISPR proteincomplex and uses of an RNA guided endonuclease in cells and organisms:

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Epub 2015 Sep. 16.-   Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas    System, Zetsche et al., Cell 163, 759-71 (Sep. 25, 2015).-   Discovery and Functional Characterization of Diverse Class 2    CRISPR-Cas Systems, Shmakov et al., Molecular Cell, 60(3), 385-397    doi: 10.1016/j.molcel.2015.10.008 Epub Oct. 22, 2015.-   Rationally engineered Cas9 nucleases with improved specificity,    Slaymaker et al., Science 2016 Jan. 1 351(6268): 84-88 doi:    10.1126/science.aad5227. Epub 2015 Dec. 1.-   Gao et al, “Engineered Cpf1 Enzymes with Altered PAM Specificities,”    bioRxiv 091611; doi: http://dx.doi.org/10.1101/091611 (Dec. 4,    2016).-   Cox et al., “RNA editing with CRISPR-Cas13,” Science. 2017 Nov. 24;    358(6366):1019-1027. doi: 10.1126/science.aaq0180. 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each of which is incorporated herein by reference, may be considered inthe practice of the instant invention, and discussed briefly below:

-   -   Cong et al. engineered type II CRISPR-Cas systems for use in        eukaryotic cells based on both Streptococcus thermophilus Cas9        and also Streptococcus pyogenes Cas9 and demonstrated that Cas9        nucleases can be directed by short RNAs to induce precise        cleavage of DNA in human and mouse cells. Their study further        showed that Cas9 as converted into a nicking enzyme can be used        to facilitate homology-directed repair in eukaryotic cells with        minimal mutagenic activity. Additionally, their study        demonstrated that multiple guide sequences can be encoded into a        single CRISPR array to enable simultaneous editing of several at        endogenous genomic loci sites within the mammalian genome,        demonstrating easy programmability and wide applicability of the        RNA-guided nuclease technology. This ability to use RNA to        program sequence specific DNA cleavage in cells defined a new        class of genome engineering tools. These studies further showed        that other CRISPR loci are likely to be transplantable into        mammalian cells and can also mediate mammalian genome cleavage.        Importantly, it can be envisaged that several aspects of the        CRISPR-Cas system can be further improved to increase its        efficiency and versatility.    -   Jiang et al. used the clustered, regularly interspaced, short        palindromic repeats (CRISPR)-associated Cas9 endonuclease        complexed with dual-RNAs to introduce precise mutations in the        genomes of Streptococcus pneumoniae and Escherichia coli. The        approach relied on dual-RNA:Cas9-directed cleavage at the        targeted genomic site to kill unmutated cells and circumvents        the need for selectable markers or counter-selection systems.        The study reported reprogramming dual-RNA:Cas9 specificity by        changing the sequence of short CRISPR RNA (crRNA) to make        single- and multinucleotide changes carried on editing        templates. The study showed that simultaneous use of two crRNAs        enabled multiplex mutagenesis. Furthermore, when the approach        was used in combination with recombineering, in S. pneumoniae,        nearly 100% of cells that were recovered using the described        approach contained the desired mutation, and in E. coli, 65%        that were recovered contained the mutation.    -   Wang et al. (2013) used the CRISPR-Cas system for the one-step        generation of mice carrying mutations in multiple genes which        were traditionally generated in multiple steps by sequential        recombination in embryonic stem cells and/or time-consuming        intercrossing of mice with a single mutation. The CRISPR-Cas        system will greatly accelerate the in vivo study of functionally        redundant genes and of epistatic gene interactions.    -   Konermann et al. (2013) addressed the need in the art for        versatile and robust technologies that enable optical and        chemical modulation of DNA-binding domains based CRISPR Cas9        enzyme and also Transcriptional Activator Like Effectors    -   Ran et al. (2013-A) described an approach that combined a Cas9        nickase mutant with paired guide RNAs to introduce targeted        double-strand breaks. This addresses the issue of the Cas9        nuclease from the microbial CRISPR-Cas system being targeted to        specific genomic loci by a guide sequence, which can tolerate        certain mismatches to the DNA target and thereby promote        undesired off-target mutagenesis. Because individual nicks in        the genome are repaired with high fidelity, simultaneous nicking        via appropriately offset guide RNAs is required for        double-stranded breaks and extends the number of specifically        recognized bases for target cleavage. The authors demonstrated        that using paired nicking can reduce off-target activity by 50-        to 1,500-fold in cell lines and to facilitate gene knockout in        mouse zygotes without sacrificing on-target cleavage efficiency.        This versatile strategy enables a wide variety of genome editing        applications that require high specificity.    -   Hsu et al. (2013) characterized SpCas9 targeting specificity in        human cells to inform the selection of target sites and avoid        off-target effects. The study evaluated >700 guide RNA variants        and SpCas9-induced indel mutation levels at >100 predicted        genomic off-target loci in 293T and 293FT cells. The authors        that SpCas9 tolerates mismatches between guide RNA and target        DNA at different positions in a sequence-dependent manner,        sensitive to the number, position and distribution of        mismatches. The authors further showed that SpCas9-mediated        cleavage is unaffected by DNA methylation and that the dosage of        SpCas9 and guide RNA can be titrated to minimize off-target        modification. Additionally, to facilitate mammalian genome        engineering applications, the authors reported providing a        web-based software tool to guide the selection and validation of        target sequences as well as off-target analyses.    -   Ran et al. (2013-B) described a set of tools for Cas9-mediated        genome editing via non-homologous end joining (NHEJ) or        homology-directed repair (HDR) in mammalian cells, as well as        generation of modified cell lines for downstream functional        studies. To minimize off-target cleavage, the authors further        described a double-nicking strategy using the Cas9 nickase        mutant with paired guide RNAs. The protocol provided by the        authors experimentally derived guidelines for the selection of        target sites, evaluation of cleavage efficiency and analysis of        off-target activity. The studies showed that beginning with        target design, gene modifications can be achieved within as        little as 1-2 weeks, and modified clonal cell lines can be        derived within 2-3 weeks.    -   Shalem et al. described a new way to interrogate gene function        on a genome-wide scale. Their studies showed that delivery of a        genome-scale CRISPR-Cas9 knockout (GeCKO) library targeted        18,080 genes with 64,751 unique guide sequences enabled both        negative and positive selection screening in human cells. First,        the authors showed use of the GeCKO library to identify genes        essential for cell viability in cancer and pluripotent stem        cells. Next, in a melanoma model, the authors screened for genes        whose loss is involved in resistance to vemurafenib, a        therapeutic that inhibits mutant protein kinase BRAF. Their        studies showed that the highest-ranking candidates included        previously validated genes NF1 and MED12 as well as novel hits        NF2, CUL3, TADA2B, and TADA1. The authors observed a high level        of consistency between independent guide RNAs targeting the same        gene and a high rate of hit confirmation, and thus demonstrated        the promise of genome-scale screening with Cas9.    -   Nishimasu et al. reported the crystal structure of Streptococcus        pyogenes Cas9 in complex with sgRNA and its target DNA at 2.5 A°        resolution. The structure revealed a bilobed architecture        composed of target recognition and nuclease lobes, accommodating        the sgRNA:DNA heteroduplex in a positively charged groove at        their interface. Whereas the recognition lobe is essential for        binding sgRNA and DNA, the nuclease lobe contains the HNH and        RuvC nuclease domains, which are properly positioned for        cleavage of the complementary and non-complementary strands of        the target DNA, respectively. The nuclease lobe also contains a        carboxyl-terminal domain responsible for the interaction with        the protospacer adjacent motif (PAM). This high-resolution        structure and accompanying functional analyses have revealed the        molecular mechanism of RNA-guided DNA targeting by Cas9, thus        paving the way for the rational design of new, versatile        genome-editing technologies.    -   Wu et al. mapped genome-wide binding sites of a catalytically        inactive Cas9 (dCas9) from Streptococcus pyogenes loaded with        single guide RNAs (sgRNAs) in mouse embryonic stem cells        (mESCs). The authors showed that each of the four sgRNAs tested        targets dCas9 to between tens and thousands of genomic sites,        frequently characterized by a 5-nucleotide seed region in the        sgRNA and an NGG protospacer adjacent motif (PAM). Chromatin        inaccessibility decreases dCas9 binding to other sites with        matching seed sequences; thus 70% of off-target sites are        associated with genes. The authors showed that targeted        sequencing of 295 dCas9 binding sites in mESCs transfected with        catalytically active Cas9 identified only one site mutated above        background levels. The authors proposed a two-state model for        Cas9 binding and cleavage, in which a seed match triggers        binding but extensive pairing with target DNA is required for        cleavage.    -   Platt et al. established a Cre-dependent Cas9 knockin mouse. The        authors demonstrated in vivo as well as ex vivo genome editing        using adeno-associated virus (AAV)-, lentivirus-, or        particle-mediated delivery of guide RNA in neurons, immune        cells, and endothelial cells.    -   Hsu et al. (2014) is a review article that discusses generally        CRISPR-Cas9 history from yogurt to genome editing, including        genetic screening of cells.    -   Wang et al. (2014) relates to a pooled, loss-of-function genetic        screening approach suitable for both positive and negative        selection that uses a genome-scale lentiviral single guide RNA        (sgRNA) library.    -   Doench et al. created a pool of sgRNAs, tiling across all        possible target sites of a panel of six endogenous mouse and        three endogenous human genes and quantitatively assessed their        ability to produce null alleles of their target gene by antibody        staining and flow cytometry. The authors showed that        optimization of the PAM improved activity and also provided an        on-line tool for designing sgRNAs.    -   Swiech et al. demonstrate that AAV-mediated SpCas9 genome        editing can enable reverse genetic studies of gene function in        the brain.    -   Konermann et al. (2015) discusses the ability to attach multiple        effector domains, e.g., transcriptional activator, functional        and epigenomic regulators at appropriate positions on the guide        such as stem or tetraloop with and without linkers.    -   Zetsche et al. demonstrates that the Cas9 enzyme can be split        into two and hence the assembly of Cas9 for activation can be        controlled.    -   Chen et al. relates to multiplex screening by demonstrating that        a genome-wide in vivo CRISPR-Cas9 screen in mice reveals genes        regulating lung metastasis.    -   Ran et al. (2015) relates to SaCas9 and its ability to edit        genomes and demonstrates that one cannot extrapolate from        biochemical assays.    -   Shalem et al. (2015) described ways in which catalytically        inactive Cas9 (dCas9) fusions are used to synthetically repress        (CRISPRi) or activate (CRISPRa) expression, showing. advances        using Cas9 for genome-scale screens, including arrayed and        pooled screens, knockout approaches that inactivate genomic loci        and strategies that modulate transcriptional activity.    -   Xu et al. (2015) assessed the DNA sequence features that        contribute to single guide RNA (sgRNA) efficiency in        CRISPR-based screens. The authors explored efficiency of        CRISPR-Cas9 knockout and nucleotide preference at the cleavage        site. The authors also found that the sequence preference for        CRISPRi/a is substantially different from that for CRISPR-Cas9        knockout.    -   Parnas et al. (2015) introduced genome-wide pooled CRISPR-Cas9        libraries into dendritic cells (DCs) to identify genes that        control the induction of tumor necrosis factor (Tnf) by        bacterial lipopolysaccharide (LPS). Known regulators of Tlr4        signaling and previously unknown candidates were identified and        classified into three functional modules with distinct effects        on the canonical responses to LPS.    -   Ramanan et al (2015) demonstrated cleavage of viral episomal DNA        (cccDNA) in infected cells. The HBV genome exists in the nuclei        of infected hepatocytes as a 3.2 kb double-stranded episomal DNA        species called covalently closed circular DNA (cccDNA), which is        a key component in the HBV life cycle whose replication is not        inhibited by current therapies. The authors showed that sgRNAs        specifically targeting highly conserved regions of HBV robustly        suppresses viral replication and depleted cccDNA.    -   Nishimasu et al. (2015) reported the crystal structures of        SaCas9 in complex with a single guide RNA (sgRNA) and its        double-stranded DNA targets, containing the 5′-TTGAAT-3′ PAM and        the 5′-TTGGGT-3′ PAM. A structural comparison of SaCas9 with        SpCas9 highlighted both structural conservation and divergence,        explaining their distinct PAM specificities and orthologous        sgRNA recognition.    -   Canver et al. (2015) demonstrated a CRISPR-Cas9-based functional        investigation of non-coding genomic elements. The authors we        developed pooled CRISPR-Cas9 guide RNA libraries to perform in        situ saturating mutagenesis of the human and mouse BCL11A        enhancers which revealed critical features of the enhancers.    -   Zetsche et al. (2015) reported characterization of Cpf1, a class        2 CRISPR nuclease from Francisella novicida U112 having features        distinct from Cas9. Cpf1 is a single RNA-guided endonuclease        lacking tracrRNA, utilizes a T-rich protospacer-adjacent motif,        and cleaves DNA via a staggered DNA double-stranded break.    -   Shmakov et al. (2015) reported three distinct Class 2 CRISPR-Cas        systems. Two system CRISPR enzymes (C2c1 and C2c3) contain        RuvC-like endonuclease domains distantly related to Cpf1. Unlike        Cpf1, C2c1 depends on both crRNA and tracrRNA for DNA cleavage.        The third enzyme (C2c2) contains two predicted HEPN RNase        domains and is tracrRNA independent.    -   Slaymaker et al (2016) reported the use of structure-guided        protein engineering to improve the specificity of Streptococcus        pyogenes Cas9 (SpCas9). The authors developed “enhanced        specificity” SpCas9 (eSpCas9) variants which maintained robust        on-target cleavage with reduced off-target effects.    -   Cox et al., (2017) reported the use of catalytically inactive        Cas13 (dCas13) to direct adenosine-to-inosine deaminase activity        by ADAR2 (adenosine deaminase acting on RNA type 2) to        transcripts in mammalian cells. The system, referred to as RNA        Editing for Programmable A to I Replacement (REPAIR), has no        strict sequence constraints and can be used to edit full-length        transcripts. The authors further engineered the system to create        a high-specificity variant and minimized the system to        facilitate viral delivery.

The methods and tools provided herein are may be designed for use withor Cas13, a type II nuclease that does not make use of tracrRNA.Orthologs of Cas13 have been identified in different bacterial speciesas described herein. Further type II nucleases with similar propertiescan be identified using methods described in the art (Shmakov et al.2015, 60:385-397; Abudayeh et al. 2016, Science, 5; 353(6299)). Inparticular embodiments, such methods for identifying novel CRISPReffector proteins may comprise the steps of selecting sequences from thedatabase encoding a seed which identifies the presence of a CRISPR Caslocus, identifying loci located within 10 kb of the seed comprising OpenReading Frames (ORFs) in the selected sequences, selecting therefromloci comprising ORFs of which only a single ORF encodes a novel CRISPReffector having greater than 700 amino acids and no more than 90%homology to a known CRISPR effector. In particular embodiments, the seedis a protein that is common to the CRISPR-Cas system, such as Cas1. Infurther embodiments, the CRISPR array is used as a seed to identify neweffector proteins.

Also, “Dimeric CRISPR RNA-guided FokI nucleases for highly specificgenome editing”, Shengdar Q. Tsai, Nicolas Wyvekens, Cyd Khayter,Jennifer A. Foden, Vishal Thapar, Deepak Reyon, Mathew J. Goodwin,Martin J. Aryee, J. Keith Joung Nature Biotechnology 32(6): 569-77(2014), relates to dimeric RNA-guided FokI Nucleases that recognizeextended sequences and can edit endogenous genes with high efficienciesin human cells.

Also, Harrington et al. “Programmed DNA destruction by miniatureCRISPR-Cas14 enzymes” Science 2018 doi:10/1126/science.aav4293, relatesto Cas14.

With respect to general information on CRISPR/Cas Systems, componentsthereof, and delivery of such components, including methods, materials,delivery vehicles, vectors, particles, and making and using thereof,including as to amounts and formulations, as well asCRISPR-Cas-expressing eukaryotic cells, CRISPR-Cas expressingeukaryotes, such as a mouse, reference is made to: U.S. Pat. Nos.8,999,641, 8,993,233, 8,697,359, 8,771,945, 8,795,965, 8,865,406,8,871,445, 8,889,356, 8,889,418, 8,895,308, 8,906,616, 8,932,814, and8,945,839; US Patent Publications US 2014-0310830 (U.S. application Ser.No. 14/105,031), US 2014-0287938 A1 (U.S. application Ser. No.14/213,991), US 2014-0273234 A1 (U.S. application Ser. No. 14/293,674),US2014-0273232 A1 (U.S. application Ser. No. 14/290,575), US2014-0273231 (U.S. application Ser. No. 14/259,420), US 2014-0256046 A1(U.S. application Ser. No. 14/226,274), US 2014-0248702 A1 (U.S.application Ser. No. 14/258,458), US 2014-0242700 A1 (U.S. applicationSer. No. 14/222,930), US 2014-0242699 A1 (U.S. application Ser. No.14/183,512), US 2014-0242664 A1 (U.S. application Ser. No. 14/104,990),US 2014-0234972 A1 (U.S. application Ser. No. 14/183,471), US2014-0227787 A1 (U.S. application Ser. No. 14/256,912), US 2014-0189896A1 (U.S. application Ser. No. 14/105,035), US 2014-0186958 (U.S.application Ser. No. 14/105,017), US 2014-0186919 A1 (U.S. applicationSer. No. 14/104,977), US 2014-0186843 A1 (U.S. application Ser. No.14/104,900), US 2014-0179770 A1 (U.S. application Ser. No. 14/104,837)and US 2014-0179006 A1 (U.S. application Ser. No. 14/183,486), US2014-0170753 (U.S. application Ser. No. 14/183,429); US 2015-0184139(U.S. application Ser. No. 14/324,960); Ser. No. 14/054,414 EuropeanPatent Applications EP 2 771 468 (EP13818570.7), EP 2 764 103(EP13824232.6), and EP 2 784 162 (EP14170383.5); and PCT PatentPublications WO2014/093661 (PCT/US2013/074743), WO2014/093694(PCT/US2013/074790), WO2014/093595 (PCT/US2013/074611), WO2014/093718(PCT/US2013/074825), WO2014/093709 (PCT/US2013/074812), WO2014/093622(PCT/US2013/074667), WO2014/093635 (PCT/US2013/074691), WO2014/093655(PCT/US2013/074736), WO2014/093712 (PCT/US2013/074819), WO2014/093701(PCT/US2013/074800), WO2014/018423 (PCT/US2013/051418), WO2014/204723(PCT/US2014/041790), WO2014/204724 (PCT/US2014/041800), WO2014/204725(PCT/US2014/041803), WO2014/204726 (PCT/US2014/041804), WO2014/204727(PCT/US2014/041806), WO2014/204728 (PCT/US2014/041808), WO2014/204729(PCT/US2014/041809), WO2015/089351 (PCT/US2014/069897), WO2015/089354(PCT/US2014/069902), WO2015/089364 (PCT/US2014/069925), WO2015/089427(PCT/US2014/070068), WO2015/089462 (PCT/US2014/070127), WO2015/089419(PCT/US2014/070057), WO2015/089465 (PCT/US2014/070135), WO2015/089486(PCT/US2014/070175), WO2015/058052 (PCT/US2014/061077), WO2015/070083(PCT/US2014/064663), WO2015/089354 (PCT/US2014/069902), WO2015/089351(PCT/US2014/069897), WO2015/089364 (PCT/US2014/069925), WO2015/089427(PCT/US2014/070068), WO2015/089473 (PCT/US2014/070152), WO2015/089486(PCT/US2014/070175), WO2016/049258 (PCT/US2015/051830), WO2016/094867(PCT/US2015/065385), WO2016/094872 (PCT/US2015/065393), WO2016/094874(PCT/US2015/065396), WO2016/106244 (PCT/US2015/067177).

Mention is also made of U.S. application 62/180,709, 17 Jun. 2015,PROTECTED GUIDE RNAS (PGRNAS); U.S. application 62/091,455, filed, 12Dec. 2014, PROTECTED GUIDE RNAS (PGRNAS); U.S. application 62/096,708,24 Dec. 2014, PROTECTED GUIDE RNAS (PGRNAS); U.S. applications62/091,462, 12 Dec. 2014, 62/096,324, 23 Dec. 2014, 62/180,681, 17 Jun.2015, and 62/237,496, 5 Oct. 2015, DEAD GUIDES FOR CRISPR TRANSCRIPTIONFACTORS; U.S. application 62/091,456, 12 Dec. 2014 and 62/180,692, 17Jun. 2015, ESCORTED AND FUNCTIONALIZED GUIDES FOR CRISPR-CAS SYSTEMS;U.S. application 62/091,461, 12 Dec. 2014, DELIVERY, USE AND THERAPEUTICAPPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR GENOMEEDITING AS TO HEMATOPOETIC STEM CELLS (HSCs); U.S. application62/094,903, 19 Dec. 2014, UNBIASED IDENTIFICATION OF DOUBLE-STRANDBREAKS AND GENOMIC REARRANGEMENT BY GENOME-WISE INSERT CAPTURESEQUENCING; U.S. application 62/096,761, 24 Dec. 2014, ENGINEERING OFSYSTEMS, METHODS AND OPTIMIZED ENZYME AND GUIDE SCAFFOLDS FOR SEQUENCEMANIPULATION; U.S. application 62/098,059, 30 Dec. 2014, 62/181,641, 18Jun. 2015, and 62/181,667, 18 Jun. 2015, RNA-TARGETING SYSTEM; U.S.application 62/096,656, 24 Dec. 2014 and 62/181,151, 17 Jun. 2015,CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS; U.S.application 62/096,697, 24 Dec. 2014, CRISPR HAVING OR ASSOCIATED WITHAAV; U.S. application 62/098,158, 30 Dec. 2014, ENGINEERED CRISPRCOMPLEX INSERTIONAL TARGETING SYSTEMS; U.S. application 62/151,052, 22Apr. 2015, CELLULAR TARGETING FOR EXTRACELLULAR EXOSOMAL REPORTING; U.S.application 62/054,490, 24 Sep. 2014, DELIVERY, USE AND THERAPEUTICAPPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETINGDISORDERS AND DISEASES USING PARTICLE DELIVERY COMPONENTS; U.S.application 61/939,154, 12 Feb. 2014, SYSTEMS, METHODS AND COMPOSITIONSFOR SEQUENCE MANIPULATION WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS;U.S. application 62/055,484, 25 Sep. 2014, SYSTEMS, METHODS ANDCOMPOSITIONS FOR SEQUENCE MANIPULATION WITH OPTIMIZED FUNCTIONALCRISPR-CAS SYSTEMS; U.S. application 62/087,537, 4 Dec. 2014, SYSTEMS,METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH OPTIMIZEDFUNCTIONAL CRISPR-CAS SYSTEMS; U.S. application 62/054,651, 24 Sep.2014, DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CASSYSTEMS AND COMPOSITIONS FOR MODELING COMPETITION OF MULTIPLE CANCERMUTATIONS IN VIVO; U.S. application 62/067,886, 23 Oct. 2014, DELIVERY,USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS ANDCOMPOSITIONS FOR MODELING COMPETITION OF MULTIPLE CANCER MUTATIONS INVIVO; U.S. applications 62/054,675, 24 Sep. 2014 and 62/181,002, 17 Jun.2015, DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CASSYSTEMS AND COMPOSITIONS IN NEURONAL CELLS/TISSUES; U.S. application62/054,528, 24 Sep. 2014, DELIVERY, USE AND THERAPEUTIC APPLICATIONS OFTHE CRISPR-CAS SYSTEMS AND COMPOSITIONS IN IMMUNE DISEASES OR DISORDERS;U.S. application 62/055,454, 25 Sep. 2014, DELIVERY, USE AND THERAPEUTICAPPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETINGDISORDERS AND DISEASES USING CELL PENETRATION PEPTIDES (CPP); U.S.application 62/055,460, 25 Sep. 2014, MULTIFUNCTIONAL-CRISPR COMPLEXESAND/OR OPTIMIZED ENZYME LINKED FUNCTIONAL-CRISPR COMPLEXES; U.S.application 62/087,475, 4 Dec. 2014 and 62/181,690, 18 Jun. 2015,FUNCTIONAL SCREENING WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS; U.S.application 62/055,487, 25 Sep. 2014, FUNCTIONAL SCREENING WITHOPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS; U.S. application 62/087,546, 4Dec. 2014 and 62/181,687, 18 Jun. 2015, MULTIFUNCTIONAL CRISPR COMPLEXESAND/OR OPTIMIZED ENZYME LINKED FUNCTIONAL-CRISPR COMPLEXES; and U.S.application 62/098,285, 30 Dec. 2014, CRISPR MEDIATED IN VIVO MODELINGAND GENETIC SCREENING OF TUMOR GROWTH AND METASTASIS.

Mention is made of U.S. applications 62/181,659, 18 Jun. 2015 and62/207,318, 19 Aug. 2015, ENGINEERING AND OPTIMIZATION OF SYSTEMS,METHODS, ENZYME AND GUIDE SCAFFOLDS OF CAS9 ORTHOLOGS AND VARIANTS FORSEQUENCE MANIPULATION. Mention is made of U.S. applications 62/181,663,18 Jun. 2015 and 62/245,264, 22 Oct. 2015, NOVEL CRISPR ENZYMES ANDSYSTEMS, U.S. applications 62/181,675, 18 Jun. 2015, 62/285,349, 22 Oct.2015, 62/296,522, 17 Feb. 2016, and 62/320,231, 8 Apr. 2016, NOVELCRISPR ENZYMES AND SYSTEMS, U.S. application 62/232,067, 24 Sep. 2015,U.S. application Ser. No. 14/975,085, 18 Dec. 2015, European applicationNo. 16150428.7, U.S. application 62/205,733, 16 Aug. 2015, U.S.application 62/201,542, 5 Aug. 2015, U.S. application 62/193,507, 16Jul. 2015, and U.S. application 62/181,739, 18 Jun. 2015, each entitledNOVEL CRISPR ENZYMES AND SYSTEMS and of U.S. application 62/245,270, 22Oct. 2015, NOVEL CRISPR ENZYMES AND SYSTEMS. Mention is also made ofU.S. application 61/939,256, 12 Feb. 2014, and WO 2015/089473(PCT/US2014/070152), 12 Dec. 2014, each entitled ENGINEERING OF SYSTEMS,METHODS AND OPTIMIZED GUIDE COMPOSITIONS WITH NEW ARCHITECTURES FORSEQUENCE MANIPULATION. Mention is also made of PCT/US2015/045504, 15Aug. 2015, U.S. application 62/180,699, 17 Jun. 2015, and U.S.application 62/038,358, 17 Aug. 2014, each entitled GENOME EDITING USINGCAS9 NICKASES.

Each of these patents, patent publications, and applications, and alldocuments cited therein or during their prosecution (“appln citeddocuments”) and all documents cited or referenced in the appln citeddocuments, together with any instructions, descriptions, productspecifications, and product sheets for any products mentioned therein orin any document therein and incorporated by reference herein, are herebyincorporated herein by reference, and may be employed in the practice ofthe invention. All documents (e.g., these patents, patent publicationsand applications and the appln cited documents) are incorporated hereinby reference to the same extent as if each individual document wasspecifically and individually indicated to be incorporated by reference.

In particular embodiments, pre-complexed guide RNA and CRISPR effectorprotein, (optionally, adenosine deaminase fused to a CRISPR protein oran adaptor) are delivered as a ribonucleoprotein (RNP). RNPs have theadvantage that they lead to rapid editing effects even more so than theRNA method because this process avoids the need for transcription. Animportant advantage is that both RNP delivery is transient, reducingoff-target effects and toxicity issues. Efficient genome editing indifferent cell types has been observed by Kim et al. (2014, Genome Res.24(6):1012-9), Paix et al. (2015, Genetics 204(1):47-54), Chu et al.(2016, BMC Biotechnol. 16:4), and Wang et al. (2013, Cell. 9;153(4):910-8).

In particular embodiments, the ribonucleoprotein is delivered by way ofa polypeptide-based shuttle agent as described in WO2016161516.WO2016161516 describes efficient transduction of polypeptide cargosusing synthetic peptides comprising an endosome leakage domain (ELD)operably linked to a cell penetrating domain (CPD), to a histidine-richdomain and a CPD. Similarly these polypeptides can be used for thedelivery of CRISPR-effector based RNPs in eukaryotic cells.

Tale Systems

As disclosed herein editing can be made by way of the transcriptionactivator-like effector nucleases (TALENs) system. Transcriptionactivator-like effectors (TALEs) can be engineered to bind practicallyany desired DNA sequence. Exemplary methods of genome editing using theTALEN system can be found for example in Cermak T. Doyle E L. ChristianM. Wang L. Zhang Y. Schmidt C, et al. Efficient design and assembly ofcustom TALEN and other TAL effector-based constructs for DNA targeting.Nucleic Acids Res. 2011; 39:e82; Zhang F. Cong L. Lodato S. Kosuri S.Church G M. Arlotta P Efficient construction of sequence-specific TALeffectors for modulating mammalian transcription. Nat Biotechnol. 2011;29:149-153 and U.S. Pat. Nos. 8,450,471, 8,440,431 and 8,440,432, all ofwhich are specifically incorporated by reference.

In advantageous embodiments of the invention, the methods providedherein use isolated, non-naturally occurring, recombinant or engineeredDNA binding proteins that comprise TALE monomers as a part of theirorganizational structure that enable the targeting of nucleic acidsequences with improved efficiency and expanded specificity.

Naturally occurring TALEs or “wild type TALEs” are nucleic acid bindingproteins secreted by numerous species of proteobacteria. TALEpolypeptides contain a nucleic acid binding domain composed of tandemrepeats of highly conserved monomer polypeptides that are predominantly33, 34 or 35 amino acids in length and that differ from each othermainly in amino acid positions 12 and 13. In advantageous embodimentsthe nucleic acid is DNA. As used herein, the term “polypeptidemonomers”, or “TALE monomers” will be used to refer to the highlyconserved repetitive polypeptide sequences within the TALE nucleic acidbinding domain and the term “repeat variable di-residues” or “RVD” willbe used to refer to the highly variable amino acids at positions 12 and13 of the polypeptide monomers. As provided throughout the disclosure,the amino acid residues of the RVD are depicted using the IUPAC singleletter code for amino acids. A general representation of a TALE monomerwhich is comprised within the DNA binding domain isX1-11-(X12X13)-X14-33 or 34 or 35, where the subscript indicates theamino acid position and X represents any amino acid. X12X13 indicate theRVDs. In some polypeptide monomers, the variable amino acid at position13 is missing or absent and in such polypeptide monomers, the RVDconsists of a single amino acid. In such cases the RVD may bealternatively represented as X*, where X represents X12 and (*)indicates that X13 is absent. The DNA binding domain comprises severalrepeats of TALE monomers and this may be represented as(X1-11-(X12X13)-X14-33 or 34 or 35)z, where in an advantageousembodiment, z is at least 5 to 40. In a further advantageous embodiment,z is at least 10 to 26.

The TALE monomers have a nucleotide binding affinity that is determinedby the identity of the amino acids in its RVD. For example, polypeptidemonomers with an RVD of NI preferentially bind to adenine (A),polypeptide monomers with an RVD of NG preferentially bind to thymine(T), polypeptide monomers with an RVD of HD preferentially bind tocytosine (C) and polypeptide monomers with an RVD of NN preferentiallybind to both adenine (A) and guanine (G). In yet another embodiment ofthe invention, polypeptide monomers with an RVD of IG preferentiallybind to T. Thus, the number and order of the polypeptide monomer repeatsin the nucleic acid binding domain of a TALE determines its nucleic acidtarget specificity. In still further embodiments of the invention,polypeptide monomers with an RVD of NS recognize all four base pairs andmay bind to A, T, G or C. The structure and function of TALEs is furtherdescribed in, for example, Moscou et al., Science 326:1501 (2009); Bochet al., Science 326:1509-1512 (2009); and Zhang et al., NatureBiotechnology 29:149-153 (2011), each of which is incorporated byreference in its entirety.

The TALE polypeptides used in methods of the invention are isolated,non-naturally occurring, recombinant or engineered nucleic acid-bindingproteins that have nucleic acid or DNA binding regions containingpolypeptide monomer repeats that are designed to target specific nucleicacid sequences.

As described herein, polypeptide monomers having an RVD of HN or NHpreferentially bind to guanine and thereby allow the generation of TALEpolypeptides with high binding specificity for guanine containing targetnucleic acid sequences. In a preferred embodiment of the invention,polypeptide monomers having RVDs RN, NN, NK, SN, NH, KN, HN, NQ, HH, RG,KH, RH and SS preferentially bind to guanine. In a much moreadvantageous embodiment of the invention, polypeptide monomers havingRVDs RN, NK, NQ, HH, KH, RH, SS and SN preferentially bind to guanineand thereby allow the generation of TALE polypeptides with high bindingspecificity for guanine containing target nucleic acid sequences. In aneven more advantageous embodiment of the invention, polypeptide monomershaving RVDs HH, KH, NH, NK, NQ, RH, RN and SS preferentially bind toguanine and thereby allow the generation of TALE polypeptides with highbinding specificity for guanine containing target nucleic acidsequences. In a further advantageous embodiment, the RVDs that have highbinding specificity for guanine are RN, NH RH and KH. Furthermore,polypeptide monomers having an RVD of NV preferentially bind to adenineand guanine. In more preferred embodiments of the invention, polypeptidemonomers having RVDs of H*, HA, KA, N*, NA, NC, NS, RA, and S* bind toadenine, guanine, cytosine and thymine with comparable affinity.

The predetermined N-terminal to C-terminal order of the one or morepolypeptide monomers of the nucleic acid or DNA binding domaindetermines the corresponding predetermined target nucleic acid sequenceto which the TALE polypeptides will bind. As used herein the polypeptidemonomers and at least one or more half polypeptide monomers are“specifically ordered to target” the genomic locus or gene of interest.In plant genomes, the natural TALE-binding sites always begin with athymine (T), which may be specified by a cryptic signal within thenon-repetitive N-terminus of the TALE polypeptide; in some cases thisregion may be referred to as repeat 0. In animal genomes, TALE bindingsites do not necessarily have to begin with a thymine (T) and TALEpolypeptides may target DNA sequences that begin with T, A, G or C. Thetandem repeat of TALE monomers always ends with a half-length repeat ora stretch of sequence that may share identity with only the first 20amino acids of a repetitive full length TALE monomer and this halfrepeat may be referred to as a half-monomer (FIG. 8 ), which is includedin the term “TALE monomer”. Therefore, it follows that the length of thenucleic acid or DNA being targeted is equal to the number of fullpolypeptide monomers plus two.

As described in Zhang et al., Nature Biotechnology 29:149-153 (2011),TALE polypeptide binding efficiency may be increased by including aminoacid sequences from the “capping regions” that are directly N-terminalor C-terminal of the DNA binding region of naturally occurring TALEsinto the engineered TALEs at positions N-terminal or C-terminal of theengineered TALE DNA binding region. Thus, in certain embodiments, theTALE polypeptides described herein further comprise an N-terminalcapping region and/or a C-terminal capping region.

An exemplary amino acid sequence of a N-terminal capping region is:

(SEQ ID No. 3) M D P I R S R T P S P A R E L L S G P Q P D G V Q PT A D R G V S P P A G G P L D G L P A R R T M S R TR L P S P P A P S P A F S A D S F S D L L R F D P SL F N T S L F D S L P P F G A H H T E A A T G E W DE V Q S G L R A A D A P P P T M R V A V T A A R P PR A K P A P R R R A A Q P S D A S P A A Q V D L R TL G Y S Q Q Q Q E K I K P K V R S T V A Q H H E A LV G H G F T H A H I V A L S Q H P A A L G T V A V KY Q D M I A A L P E A T H E A I V G V G K Q W S G AR A L E A L L T V A G E L R G P P L Q L D T G Q L LK I A K R G G V T A V E A V H A W R N A L T G A P L NAn exemplary amino acid sequence of a C-terminal capping region is:

(SEQ ID No. 4) R P A L E S I V A Q L S R P D P A L A A L T N D H LV A L A C L G G R P A L D A V K K G L P H A P A L IK R T N R R I P E R T S H R V A D H A Q V V R V L GF F Q C H S H P A Q A F D D A M T Q F G M S R H G LL Q L F R R V G V T E L E A R S G T L P P A S Q R WD R I L Q A S G M K R A K P S P T S T Q T P D Q A SL H A F A D S L E R D L D A P S P M H E G D Q T R A S

As used herein the predetermined “N-terminus” to “C terminus”orientation of the N-terminal capping region, the DNA binding domaincomprising the repeat TALE monomers and the C-terminal capping regionprovide structural basis for the organization of different domains inthe d-TALEs or polypeptides of the invention.

The entire N-terminal and/or C-terminal capping regions are notnecessary to enhance the binding activity of the DNA binding region.Therefore, in certain embodiments, fragments of the N-terminal and/orC-terminal capping regions are included in the TALE polypeptidesdescribed herein.

In certain embodiments, the TALE polypeptides described herein contain aN-terminal capping region fragment that included at least 10, 20, 30,40, 50, 54, 60, 70, 80, 87, 90, 94, 100, 102, 110, 117, 120, 130, 140,147, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260 or 270amino acids of an N-terminal capping region. In certain embodiments, theN-terminal capping region fragment amino acids are of the C-terminus(the DNA-binding region proximal end) of an N-terminal capping region.As described in Zhang et al., Nature Biotechnology 29:149-153 (2011),N-terminal capping region fragments that include the C-terminal 240amino acids enhance binding activity equal to the full length cappingregion, while fragments that include the C-terminal 147 amino acidsretain greater than 80% of the efficacy of the full length cappingregion, and fragments that include the C-terminal 117 amino acids retaingreater than 50% of the activity of the full-length capping region.

In some embodiments, the TALE polypeptides described herein contain aC-terminal capping region fragment that included at least 6, 10, 20, 30,37, 40, 50, 60, 68, 70, 80, 90, 100, 110, 120, 127, 130, 140, 150, 155,160, 170, 180 amino acids of a C-terminal capping region. In certainembodiments, the C-terminal capping region fragment amino acids are ofthe N-terminus (the DNA-binding region proximal end) of a C-terminalcapping region. As described in Zhang et al., Nature Biotechnology29:149-153 (2011), C-terminal capping region fragments that include theC-terminal 68 amino acids enhance binding activity equal to the fulllength capping region, while fragments that include the C-terminal 20amino acids retain greater than 50% of the efficacy of the full lengthcapping region.

In certain embodiments, the capping regions of the TALE polypeptidesdescribed herein do not need to have identical sequences to the cappingregion sequences provided herein. Thus, in some embodiments, the cappingregion of the TALE polypeptides described herein have sequences that areat least 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%,97%, 98% or 99% identical or share identity to the capping region aminoacid sequences provided herein. Sequence identity is related to sequencehomology. Homology comparisons may be conducted by eye, or more usually,with the aid of readily available sequence comparison programs. Thesecommercially available computer programs may calculate percent (%)homology between two or more sequences and may also calculate thesequence identity shared by two or more amino acid or nucleic acidsequences. In some preferred embodiments, the capping region of the TALEpolypeptides described herein have sequences that are at least 95%identical or share identity to the capping region amino acid sequencesprovided herein.

Sequence homologies may be generated by any of a number of computerprograms known in the art, which include but are not limited to BLAST orFASTA. Suitable computer program for carrying out alignments like theGCG Wisconsin Bestfit package may also be used. Once the software hasproduced an optimal alignment, it is possible to calculate % homology,preferably % sequence identity. The software typically does this as partof the sequence comparison and generates a numerical result.

In advantageous embodiments described herein, the TALE polypeptides ofthe invention include a nucleic acid binding domain linked to the one ormore effector domains. The terms “effector domain” or “regulatory andfunctional domain” refer to a polypeptide sequence that has an activityother than binding to the nucleic acid sequence recognized by thenucleic acid binding domain. By combining a nucleic acid binding domainwith one or more effector domains, the polypeptides of the invention maybe used to target the one or more functions or activities mediated bythe effector domain to a particular target DNA sequence to which thenucleic acid binding domain specifically binds.

In some embodiments of the TALE polypeptides described herein, theactivity mediated by the effector domain is a biological activity. Forexample, in some embodiments the effector domain is a transcriptionalinhibitor (i.e., a repressor domain), such as an mSin interaction domain(SID). SID4X domain or a Kruppel-associated box (KRAB) or fragments ofthe KRAB domain. In some embodiments the effector domain is an enhancerof transcription (i.e. an activation domain), such as the VP16, VP64 orp65 activation domain. In some embodiments, the nucleic acid binding islinked, for example, with an effector domain that includes but is notlimited to a transposase, integrase, recombinase, resolvase, invertase,protease, DNA methyltransferase, DNA demethylase, histone acetylase,histone deacetylase, nuclease, transcriptional repressor,transcriptional activator, transcription factor recruiting, proteinnuclear-localization signal or cellular uptake signal.

In some embodiments, the effector domain is a protein domain whichexhibits activities which include but are not limited to transposaseactivity, integrase activity, recombinase activity, resolvase activity,invertase activity, protease activity, DNA methyltransferase activity,DNA demethylase activity, histone acetylase activity, histonedeacetylase activity, nuclease activity, nuclear-localization signalingactivity, transcriptional repressor activity, transcriptional activatoractivity, transcription factor recruiting activity, or cellular uptakesignaling activity. Other preferred embodiments of the invention mayinclude any combination the activities described herein.

ZN-Finger Nucleases

Other preferred tools for genome editing for use in the context of thisinvention include zinc finger systems. One type of programmableDNA-binding domain is provided by artificial zinc-finger (ZF)technology, which involves arrays of ZF modules to target newDNA-binding sites in the genome. Each finger module in a ZF arraytargets three DNA bases. A customized array of individual zinc fingerdomains is assembled into a ZF protein (ZFP).

ZFPs can comprise a functional domain. The first synthetic zinc fingernucleases (ZFNs) were developed by fusing a ZF protein to the catalyticdomain of the Type IIS restriction enzyme FokI. (Kim, Y. G. et al.,1994, Chimeric restriction endonuclease, Proc. Natl. Acad. Sci. U.S.A.91, 883-887; Kim, Y. G. et al., 1996, Hybrid restriction enzymes: zincfinger fusions to Fok I cleavage domain. Proc. Natl. Acad. Sci. U.S.A.93, 1156-1160). Increased cleavage specificity can be attained withdecreased off target activity by use of paired ZFN heterodimers, eachtargeting different nucleotide sequences separated by a short spacer.(Doyon, Y. et al., 2011, Enhancing zinc-finger-nuclease activity withimproved obligate heterodimeric architectures. Nat. Methods 8, 74-79).ZFPs can also be designed as transcription activators and repressors andhave been used to target many genes in a wide variety of organisms.Exemplary methods of genome editing using ZFNs can be found for examplein U.S. Pat. Nos. 6,534,261, 6,607,882, 6,746,838, 6,794,136, 6,824,978,6,866,997, 6,933,113, 6,979,539, 7,013,219, 7,030,215, 7,220,719,7,241,573, 7,241,574, 7,585,849, 7,595,376, 6,903,185, and 6,479,626,all of which are specifically incorporated by reference.

Meganucleases

As disclosed herein editing can be made by way of meganucleases, whichare endodeoxyribonucleases characterized by a large recognition site(double-stranded DNA sequences of 12 to 40 base pairs). Exemplary methodfor using meganucleases can be found in U.S. Pat. Nos. 8,163,514;8,133,697; 8,021,867; 8,119,361; 8,119,381; 8,124,369; and 8,129,134,which are specifically incorporated by reference.

RNAi

In certain embodiments, the genetic modifying agent is RNAi (e.g.,shRNA). As used herein, “gene silencing” or “gene silenced” in referenceto an activity of an RNAi molecule, for example a siRNA or miRNA refersto a decrease in the mRNA level in a cell for a target gene by at leastabout 5%, about 10%, about 20%, about 30%, about 40%, about 50%, about60%, about 70%, about 80%, about 90%, about 95%, about 99%, about 100%of the mRNA level found in the cell without the presence of the miRNA orRNA interference molecule. In one preferred embodiment, the mRNA levelsare decreased by at least about 70%, about 80%, about 90%, about 95%,about 99%, about 100%.

As used herein, the term “RNAi” refers to any type of interfering RNA,including but not limited to, siRNAi, shRNAi, endogenous microRNA andartificial microRNA. For instance, it includes sequences previouslyidentified as siRNA, regardless of the mechanism of down-streamprocessing of the RNA (i.e. although siRNAs are believed to have aspecific method of in vivo processing resulting in the cleavage of mRNA,such sequences can be incorporated into the vectors in the context ofthe flanking sequences described herein). The term “RNAi” can includeboth gene silencing RNAi molecules, and also RNAi effector moleculeswhich activate the expression of a gene.

As used herein, a “siRNA” refers to a nucleic acid that forms a doublestranded RNA, which double stranded RNA has the ability to reduce orinhibit expression of a gene or target gene when the siRNA is present orexpressed in the same cell as the target gene. The double stranded RNAsiRNA can be formed by the complementary strands. In one embodiment, asiRNA refers to a nucleic acid that can form a double stranded siRNA.The sequence of the siRNA can correspond to the full-length target gene,or a subsequence thereof. Typically, the siRNA is at least about 15-50nucleotides in length (e.g., each complementary sequence of the doublestranded siRNA is about 15-50 nucleotides in length, and the doublestranded siRNA is about 15-50 base pairs in length, preferably about19-30 base nucleotides, preferably about 20-25 nucleotides in length,e.g., 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides inlength).

As used herein “shRNA” or “small hairpin RNA” (also called stem loop) isa type of siRNA. In one embodiment, these shRNAs are composed of ashort, e.g. about 19 to about 25 nucleotide, antisense strand, followedby a nucleotide loop of about 5 to about 9 nucleotides, and theanalogous sense strand. Alternatively, the sense strand can precede thenucleotide loop structure and the antisense strand can follow.

The terms “microRNA” or “miRNA” are used interchangeably herein areendogenous RNAs, some of which are known to regulate the expression ofprotein-coding genes at the posttranscriptional level. EndogenousmicroRNAs are small RNAs naturally present in the genome that arecapable of modulating the productive utilization of mRNA. The termartificial microRNA includes any type of RNA sequence, other thanendogenous microRNA, which is capable of modulating the productiveutilization of mRNA. MicroRNA sequences have been described inpublications such as Lim, et al., Genes & Development, 17, p. 991-1008(2003), Lim et al Science 299, 1540 (2003), Lee and Ambros Science, 294,862 (2001), Lau et al., Science 294, 858-861 (2001), Lagos-Quintana etal, Current Biology, 12, 735-739 (2002), Lagos Quintana et al, Science294, 853-857 (2001), and Lagos-Quintana et al, RNA, 9, 175-179 (2003),which are incorporated by reference. Multiple microRNAs can also beincorporated into a precursor molecule. Furthermore, miRNA-likestem-loops can be expressed in cells as a vehicle to deliver artificialmiRNAs and short interfering RNAs (siRNAs) for the purpose of modulatingthe expression of endogenous genes through the miRNA and or RNAipathways.

As used herein, “double stranded RNA” or “dsRNA” refers to RNA moleculesthat are comprised of two strands. Double-stranded molecules includethose comprised of a single RNA molecule that doubles back on itself toform a two-stranded structure. For example, the stem loop structure ofthe progenitor molecules from which the single-stranded miRNA isderived, called the pre-miRNA (Bartel et al. 2004. Cell 1 16:281-297),comprises a dsRNA molecule.

Antibodies

In certain embodiments, the one or more agents is an antibody. The term“antibody” is used interchangeably with the term “immunoglobulin”herein, and includes intact antibodies, fragments of antibodies, e.g.,Fab, F(ab′)2 fragments, and intact antibodies and fragments that havebeen mutated either in their constant and/or variable region (e.g.,mutations to produce chimeric, partially humanized, or fully humanizedantibodies, as well as to produce antibodies with a desired trait, e.g.,enhanced binding and/or reduced FcR binding). The term “fragment” refersto a part or portion of an antibody or antibody chain comprising feweramino acid residues than an intact or complete antibody or antibodychain. Fragments can be obtained via chemical or enzymatic treatment ofan intact or complete antibody or antibody chain. Fragments can also beobtained by recombinant means. Exemplary fragments include Fab, Fab′,F(ab′)2, Fabc, Fd, dAb, V_(HH) and scFv and/or Fv fragments.

As used herein, a preparation of antibody protein having less than about50% of non-antibody protein (also referred to herein as a “contaminatingprotein”), or of chemical precursors, is considered to be “substantiallyfree.” 40%, 30%, 20%, 10% and more preferably 5% (by dry weight), ofnon-antibody protein, or of chemical precursors is considered to besubstantially free. When the antibody protein or biologically activeportion thereof is recombinantly produced, it is also preferablysubstantially free of culture medium, i.e., culture medium representsless than about 30%, preferably less than about 20%, more preferablyless than about 10%, and most preferably less than about 5% of thevolume or mass of the protein preparation.

The term “antigen-binding fragment” refers to a polypeptide fragment ofan immunoglobulin or antibody that binds antigen or competes with intactantibody (i.e., with the intact antibody from which they were derived)for antigen binding (i.e., specific binding). As such these antibodiesor fragments thereof are included in the scope of the invention,provided that the antibody or fragment binds specifically to a targetmolecule.

It is intended that the term “antibody” encompass any Ig class or any Igsubclass (e.g. the IgG1, IgG2, IgG3, and IgG4 subclassess of IgG)obtained from any source (e.g., humans and non-human primates, and inrodents, lagomorphs, caprines, bovines, equines, ovines, etc.).

The term “Ig class” or “immunoglobulin class”, as used herein, refers tothe five classes of immunoglobulin that have been identified in humansand higher mammals, IgG, IgM, IgA, IgD, and IgE. The term “Ig subclass”refers to the two subclasses of IgM (H and L), three subclasses of IgA(IgA1, IgA2, and secretory IgA), and four subclasses of IgG (IgG1, IgG2,IgG3, and IgG4) that have been identified in humans and higher mammals.The antibodies can exist in monomeric or polymeric form; for example,lgM antibodies exist in pentameric form, and IgA antibodies exist inmonomeric, dimeric or multimeric form.

The term “IgG subclass” refers to the four subclasses of immunoglobulinclass IgG-IgG1, IgG2, IgG3, and IgG4 that have been identified in humansand higher mammals by the heavy chains of the immunoglobulins, V1-γ4,respectively. The term “single-chain immunoglobulin” or “single-chainantibody” (used interchangeably herein) refers to a protein having atwo-polypeptide chain structure consisting of a heavy and a light chain,said chains being stabilized, for example, by interchain peptidelinkers, which has the ability to specifically bind antigen. The term“domain” refers to a globular region of a heavy or light chainpolypeptide comprising peptide loops (e.g., comprising 3 to 4 peptideloops) stabilized, for example, by p pleated sheet and/or intrachaindisulfide bond. Domains are further referred to herein as “constant” or“variable”, based on the relative lack of sequence variation within thedomains of various class members in the case of a “constant” domain, orthe significant variation within the domains of various class members inthe case of a “variable” domain. Antibody or polypeptide “domains” areoften referred to interchangeably in the art as antibody or polypeptide“regions”. The “constant” domains of an antibody light chain arereferred to interchangeably as “light chain constant regions”, “lightchain constant domains”, “CL” regions or “CL” domains. The “constant”domains of an antibody heavy chain are referred to interchangeably as“heavy chain constant regions”, “heavy chain constant domains”, “CH”regions or “CH” domains). The “variable” domains of an antibody lightchain are referred to interchangeably as “light chain variable regions”,“light chain variable domains”, “VL” regions or “VL” domains). The“variable” domains of an antibody heavy chain are referred tointerchangeably as “heavy chain constant regions”, “heavy chain constantdomains”, “VH” regions or “VH” domains).

The term “region” can also refer to a part or portion of an antibodychain or antibody chain domain (e.g., a part or portion of a heavy orlight chain or a part or portion of a constant or variable domain, asdefined herein), as well as more discrete parts or portions of saidchains or domains. For example, light and heavy chains or light andheavy chain variable domains include “complementarity determiningregions” or “CDRs” interspersed among “framework regions” or “FRs”, asdefined herein.

The term “conformation” refers to the tertiary structure of a protein orpolypeptide (e.g., an antibody, antibody chain, domain or regionthereof). For example, the phrase “light (or heavy) chain conformation”refers to the tertiary structure of a light (or heavy) chain variableregion, and the phrase “antibody conformation” or “antibody fragmentconformation” refers to the tertiary structure of an antibody orfragment thereof.

The term “antibody-like protein scaffolds” or “engineered proteinscaffolds” broadly encompasses proteinaceous non-immunoglobulinspecific-binding agents, typically obtained by combinatorial engineering(such as site-directed random mutagenesis in combination with phagedisplay or other molecular selection techniques). Usually, suchscaffolds are derived from robust and small soluble monomeric proteins(such as Kunitz inhibitors or lipocalins) or from a stably foldedextra-membrane domain of a cell surface receptor (such as protein A,fibronectin or the ankyrin repeat).

Such scaffolds have been extensively reviewed in Binz et al.(Engineering novel binding proteins from nonimmunoglobulin domains. NatBiotechnol 2005, 23:1257-1268), Gebauer and Skerra (Engineered proteinscaffolds as next-generation antibody therapeutics. Curr Opin Chem Biol.2009, 13:245-55), Gill and Damle (Biopharmaceutical drug discovery usingnovel protein scaffolds. Curr Opin Biotechnol 2006, 17:653-658), Skerra(Engineered protein scaffolds for molecular recognition. J Mol Recognit2000, 13:167-187), and Skerra (Alternative non-antibody scaffolds formolecular recognition. Curr Opin Biotechnol 2007, 18:295-304), andinclude without limitation affibodies, based on the Z-domain ofstaphylococcal protein A, a three-helix bundle of 58 residues providingan interface on two of its alpha-helices (Nygren, Alternative bindingproteins: Affibody binding proteins developed from a small three-helixbundle scaffold. FEBS J 2008, 275:2668-2676); engineered Kunitz domainsbased on a small (ca. 58 residues) and robust, disulphide-crosslinkedserine protease inhibitor, typically of human origin (e.g. LACI-D1),which can be engineered for different protease specificities (Nixon andWood, Engineered protein inhibitors of proteases. Curr Opin Drug DiscovDev 2006, 9:261-268); monobodies or adnectins based on the 10thextracellular domain of human fibronectin III (10Fn3), which adopts anIg-like beta-sandwich fold (94 residues) with 2-3 exposed loops, butlacks the central disulphide bridge (Koide and Koide, Monobodies:antibody mimics based on the scaffold of the fibronectin type IIIdomain. Methods Mol Biol 2007, 352:95-109); anticalins derived from thelipocalins, a diverse family of eight-stranded beta-barrel proteins (ca.180 residues) that naturally form binding sites for small ligands bymeans of four structurally variable loops at the open end, which areabundant in humans, insects, and many other organisms (Skerra,Alternative binding proteins: Anticalins harnessing the structuralplasticity of the lipocalin ligand pocket to engineer novel bindingactivities. FEBS J 2008, 275:2677-2683); DARPins, designed ankyrinrepeat domains (166 residues), which provide a rigid interface arisingfrom typically three repeated beta-turns (Stumpp et al., DARPins: a newgeneration of protein therapeutics. Drug Discov Today 2008, 13:695-701);avimers (multimerized LDLR-A module) (Silverman et al., Multivalentavimer proteins evolved by exon shuffling of a family of human receptordomains. Nat Biotechnol 2005, 23:1556-1561); and cysteine-rich knottinpeptides (Kolmar, Alternative binding proteins: biological activity andtherapeutic potential of cystine-knot miniproteins. FEBS J 2008,275:2684-2690).

“Specific binding” of an antibody means that the antibody exhibitsappreciable affinity for a particular antigen or epitope and, generally,does not exhibit significant cross reactivity. “Appreciable” bindingincludes binding with an affinity of at least 25 μM. Antibodies withaffinities greater than 1×10⁷ M⁻¹ (or a dissociation coefficient of 1 Mor less or a dissociation coefficient of 1 nm or less) typically bindwith correspondingly greater specificity. Values intermediate of thoseset forth herein are also intended to be within the scope of the presentinvention and antibodies of the invention bind with a range ofaffinities, for example, 100 nM or less, 75 nM or less, 50 nM or less,25 nM or less, for example 10 nM or less, 5 nM or less, 1 nM or less, orin embodiments 500 pM or less, 100 pM or less, 50 pM or less or 25 pM orless. An antibody that “does not exhibit significant crossreactivity” isone that will not appreciably bind to an entity other than its target(e.g., a different epitope or a different molecule). For example, anantibody that specifically binds to a target molecule will appreciablybind the target molecule but will not significantly react withnon-target molecules or peptides. An antibody specific for a particularepitope will, for example, not significantly crossreact with remoteepitopes on the same protein or peptide. Specific binding can bedetermined according to any art-recognized means for determining suchbinding. Preferably, specific binding is determined according toScatchard analysis and/or competitive binding assays.

As used herein, the term “affinity” refers to the strength of thebinding of a single antigen-combining site with an antigenicdeterminant. Affinity depends on the closeness of stereochemical fitbetween antibody combining sites and antigen determinants, on the sizeof the area of contact between them, on the distribution of charged andhydrophobic groups, etc. Antibody affinity can be measured byequilibrium dialysis or by the kinetic BIACORE™ method. The dissociationconstant, Kd, and the association constant, Ka, are quantitativemeasures of affinity.

As used herein, the term “monoclonal antibody” refers to an antibodyderived from a clonal population of antibody-producing cells (e.g., Blymphocytes or B cells) which is homogeneous in structure and antigenspecificity. The term “polyclonal antibody” refers to a plurality ofantibodies originating from different clonal populations ofantibody-producing cells which are heterogeneous in their structure andepitope specificity but which recognize a common antigen. Monoclonal andpolyclonal antibodies may exist within bodily fluids, as crudepreparations, or may be purified, as described herein.

The term “binding portion” of an antibody (or “antibody portion”)includes one or more complete domains, e.g., a pair of complete domains,as well as fragments of an antibody that retain the ability tospecifically bind to a target molecule. It has been shown that thebinding function of an antibody can be performed by fragments of afull-length antibody. Binding fragments are produced by recombinant DNAtechniques, or by enzymatic or chemical cleavage of intactimmunoglobulins. Binding fragments include Fab, Fab′, F(ab′)2, Fabc, Fd,dAb, Fv, single chains, single-chain antibodies, e.g., scFv, and singledomain antibodies.

“Humanized” forms of non-human (e.g., murine) antibodies are chimericantibodies that contain minimal sequence derived from non-humanimmunoglobulin. For the most part, humanized antibodies are humanimmunoglobulins (recipient antibody) in which residues from ahypervariable region of the recipient are replaced by residues from ahypervariable region of a non-human species (donor antibody) such asmouse, rat, rabbit or nonhuman primate having the desired specificity,affinity, and capacity. In some instances, FR residues of the humanimmunoglobulin are replaced by corresponding non-human residues.Furthermore, humanized antibodies may comprise residues that are notfound in the recipient antibody or in the donor antibody. Thesemodifications are made to further refine antibody performance. Ingeneral, the humanized antibody will comprise substantially all of atleast one, and typically two, variable domains, in which all orsubstantially all of the hypervariable regions correspond to those of anon-human immunoglobulin and all or substantially all of the FR regionsare those of a human immunoglobulin sequence. The humanized antibodyoptionally also will comprise at least a portion of an immunoglobulinconstant region (Fc), typically that of a human immunoglobulin.

Examples of portions of antibodies or epitope-binding proteinsencompassed by the present definition include: (i) the Fab fragment,having V_(L), C_(L), V_(H) and C_(H)1 domains; (ii) the Fab′ fragment,which is a Fab fragment having one or more cysteine residues at theC-terminus of the C_(H)1 domain; (iii) the Fd fragment having V_(H) andC_(H)1 domains; (iv) the Fd′ fragment having V_(H) and C_(H)1 domainsand one or more cysteine residues at the C-terminus of the CHI domain;(v) the Fv fragment having the V_(L) and V_(H) domains of a single armof an antibody; (vi) the dAb fragment (Ward et al., 341 Nature 544(1989)) which consists of a V_(H) domain or a V_(L) domain that bindsantigen; (vii) isolated CDR regions or isolated CDR regions presented ina functional framework; (viii) F(ab′)₂ fragments which are bivalentfragments including two Fab′ fragments linked by a disulphide bridge atthe hinge region; (ix) single chain antibody molecules (e.g., singlechain Fv; scFv) (Bird et al., 242 Science 423 (1988); and Huston et al.,85 PNAS 5879 (1988)); (x) “diabodies” with two antigen binding sites,comprising a heavy chain variable domain (V_(H)) connected to a lightchain variable domain (V_(L)) in the same polypeptide chain (see, e.g.,EP 404,097; WO 93/11161; Hollinger et al., 90 PNAS 6444 (1993)); (xi)“linear antibodies” comprising a pair of tandem Fd segments(V_(H)-C_(h)1-V_(H)-C_(h)1) which, together with complementary lightchain polypeptides, form a pair of antigen binding regions (Zapata etal., Protein Eng. 8(10):1057-62 (1995); and U.S. Pat. No. 5,641,870).

As used herein, a “blocking” antibody or an antibody “antagonist” is onewhich inhibits or reduces biological activity of the antigen(s) itbinds. In certain embodiments, the blocking antibodies or antagonistantibodies or portions thereof described herein completely inhibit thebiological activity of the antigen(s).

Antibodies may act as agonists or antagonists of the recognizedpolypeptides. For example, the present invention includes antibodieswhich disrupt receptor/ligand interactions either partially or fully.The invention features both receptor-specific antibodies andligand-specific antibodies. The invention also featuresreceptor-specific antibodies which do not prevent ligand binding butprevent receptor activation. Receptor activation (i.e., signaling) maybe determined by techniques described herein or otherwise known in theart. For example, receptor activation can be determined by detecting thephosphorylation (e.g., tyrosine or serine/threonine) of the receptor orof one of its down-stream substrates by immunoprecipitation followed bywestern blot analysis. In specific embodiments, antibodies are providedthat inhibit ligand activity or receptor activity by at least 95%, atleast 90%, at least 85%, at least 80%, at least 75%, at least 70%, atleast 60%, or at least 50% of the activity in absence of the antibody.

The invention also features receptor-specific antibodies which bothprevent ligand binding and receptor activation as well as antibodiesthat recognize the receptor-ligand complex. Likewise, encompassed by theinvention are neutralizing antibodies which bind the ligand and preventbinding of the ligand to the receptor, as well as antibodies which bindthe ligand, thereby preventing receptor activation, but do not preventthe ligand from binding the receptor. Further included in the inventionare antibodies which activate the receptor. These antibodies may act asreceptor agonists, i.e., potentiate or activate either all or a subsetof the biological activities of the ligand-mediated receptor activation,for example, by inducing dimerization of the receptor. The antibodiesmay be specified as agonists, antagonists or inverse agonists forbiological activities comprising the specific biological activities ofthe peptides disclosed herein. The antibody agonists and antagonists canbe made using methods known in the art. See, e.g., PCT publication WO96/40281; U.S. Pat. No. 5,811,097; Deng et al., Blood 92(6):1981-1988(1998); Chen et al., Cancer Res. 58(16):3668-3678 (1998); Harrop et al.,J. Immunol. 161(4):1786-1794 (1998); Zhu et al., Cancer Res.58(15):3209-3214 (1998); Yoon et al., J. Immunol. 160(7):3170-3179(1998); Prat et al., J. Cell. Sci. III (Pt2):237-247 (1998); Pitard etal., J. Immunol. Methods 205(2):177-190 (1997); Liautard et al.,Cytokine 9(4):233-241 (1997); Carlson et al., J. Biol. Chem.272(17):11295-11301 (1997); Taryman et al., Neuron 14(4):755-762 (1995);Muller et al., Structure 6(9):1153-1167 (1998); Bartunek et al.,Cytokine 8(1):14-20 (1996).

The antibodies as defined for the present invention include derivativesthat are modified, i.e., by the covalent attachment of any type ofmolecule to the antibody such that covalent attachment does not preventthe antibody from generating an anti-idiotypic response. For example,but not by way of limitation, the antibody derivatives includeantibodies that have been modified, e.g., by glycosylation, acetylation,pegylation, phosphylation, amidation, derivatization by knownprotecting/blocking groups, proteolytic cleavage, linkage to a cellularligand or other protein, etc. Any of numerous chemical modifications maybe carried out by known techniques, including, but not limited tospecific chemical cleavage, acetylation, formylation, metabolicsynthesis of tunicamycin, etc. Additionally, the derivative may containone or more non-classical amino acids.

Simple binding assays can be used to screen for or detect agents thatbind to a target protein, or disrupt the interaction between proteins(e.g., a receptor and a ligand). Because certain targets of the presentinvention are transmembrane proteins, assays that use the soluble formsof these proteins rather than full-length protein can be used, in someembodiments. Soluble forms include, for example, those lacking thetransmembrane domain and/or those comprising the IgV domain or fragmentsthereof which retain their ability to bind their cognate bindingpartners. Further, agents that inhibit or enhance protein interactionsfor use in the compositions and methods described herein, can includerecombinant peptido-mimetics.

Detection methods useful in screening assays include antibody-basedmethods, detection of a reporter moiety, detection of cytokines asdescribed herein, and detection of a gene signature as described herein.

Another variation of assays to determine binding of a receptor proteinto a ligand protein is through the use of affinity biosensor methods.Such methods may be based on the piezoelectric effect, electrochemistry,or optical methods, such as ellipsometry, optical wave guidance, andsurface plasmon resonance (SPR).

Aptamers

In certain embodiments, the one or more agents is an aptamer. Nucleicacid aptamers are nucleic acid species that have been engineered throughrepeated rounds of in vitro selection or equivalently, SELEX (systematicevolution of ligands by exponential enrichment) to bind to variousmolecular targets such as small molecules, proteins, nucleic acids,cells, tissues and organisms. Nucleic acid aptamers have specificbinding affinity to molecules through interactions other than classicWatson-Crick base pairing. Aptamers are useful in biotechnological andtherapeutic applications as they offer molecular recognition propertiessimilar to antibodies. In addition to their discriminate recognition,aptamers offer advantages over antibodies as they can be engineeredcompletely in a test tube, are readily produced by chemical synthesis,possess desirable storage properties, and elicit little or noimmunogenicity in therapeutic applications. In certain embodiments, RNAaptamers may be expressed from a DNA construct. In other embodiments, anucleic acid aptamer may be linked to another polynucleotide sequence.The polynucleotide sequence may be a double stranded DNA polynucleotidesequence. The aptamer may be covalently linked to one strand of thepolynucleotide sequence. The aptamer may be ligated to thepolynucleotide sequence. The polynucleotide sequence may be configured,such that the polynucleotide sequence may be linked to a solid supportor ligated to another polynucleotide sequence.

Aptamers, like peptides generated by phage display or monoclonalantibodies (“mAbs”), are capable of specifically binding to selectedtargets and modulating the target's activity, e.g., through binding,aptamers may block their target's ability to function. A typical aptameris 10-15 kDa in size (30-45 nucleotides), binds its target withsub-nanomolar affinity, and discriminates against closely relatedtargets (e.g., aptamers will typically not bind other proteins from thesame gene family). Structural studies have shown that aptamers arecapable of using the same types of binding interactions (e.g., hydrogenbonding, electrostatic complementarity, hydrophobic contacts, stericexclusion) that drives affinity and specificity in antibody-antigencomplexes.

Aptamers have a number of desirable characteristics for use in researchand as therapeutics and diagnostics including high specificity andaffinity, biological efficacy, and excellent pharmacokinetic properties.In addition, they offer specific competitive advantages over antibodiesand other protein biologics. Aptamers are chemically synthesized and arereadily scaled as needed to meet production demand for research,diagnostic or therapeutic applications. Aptamers are chemically robust.They are intrinsically adapted to regain activity following exposure tofactors such as heat and denaturants and can be stored for extendedperiods (>1 yr) at room temperature as lyophilized powders. Not beingbound by a theory, aptamers bound to a solid support or beads may bestored for extended periods.

Oligonucleotides in their phosphodiester form may be quickly degraded byintracellular and extracellular enzymes such as endonucleases andexonucleases. Aptamers can include modified nucleotides conferringimproved characteristics on the ligand, such as improved in vivostability or improved delivery characteristics. Examples of suchmodifications include chemical substitutions at the ribose and/orphosphate and/or base positions. SELEX identified nucleic acid ligandscontaining modified nucleotides are described, e.g., in U.S. Pat. No.5,660,985, which describes oligonucleotides containing nucleotidederivatives chemically modified at the 2′ position of ribose, 5 positionof pyrimidines, and 8 position of purines, U.S. Pat. No. 5,756,703 whichdescribes oligonucleotides containing various 2′-modified pyrimidines,and U.S. Pat. No. 5,580,737 which describes highly specific nucleic acidligands containing one or more nucleotides modified with 2′-amino(2′-NH2), 2′-fluoro (2′-F), and/or 2′-O-methyl (2′-OMe) substituents.Modifications of aptamers may also include, modifications at exocyclicamines, substitution of 4-thiouridine, substitution of 5-bromo or5-iodo-uracil; backbone modifications, phosphorothioate or allylphosphate modifications, methylations, and unusual base-pairingcombinations such as the isobases isocytidine and isoguanosine.Modifications can also include 3′ and 5′ modifications such as capping.As used herein, the term phosphorothioate encompasses one or morenon-bridging oxygen atoms in a phosphodiester bond replaced by one ormore sulfur atoms. In further embodiments, the oligonucleotides comprisemodified sugar groups, for example, one or more of the hydroxyl groupsis replaced with halogen, aliphatic groups, or functionalized as ethersor amines. In one embodiment, the 2′-position of the furanose residue issubstituted by any of an O-methyl, O-alkyl, 0-allyl, S-alkyl, S-allyl,or halo group. Methods of synthesis of 2′-modified sugars are described,e.g., in Sproat, et al., Nucl. Acid Res. 19:733-738 (1991); Cotten, etal, Nucl. Acid Res. 19:2629-2635 (1991); and Hobbs, et al, Biochemistry12:5138-5145 (1973). Other modifications are known to one of ordinaryskill in the art. In certain embodiments, aptamers include aptamers withimproved off-rates as described in International Patent Publication No.WO 2009012418, “Method for generating aptamers with improved off-rates,”incorporated herein by reference in its entirety. In certain embodimentsaptamers are chosen from a library of aptamers. Such libraries include,but are not limited to those described in Rohloff et al., “Nucleic AcidLigands With Protein-like Side Chains: Modified Aptamers and Their Useas Diagnostic and Therapeutic Agents,” Molecular Therapy Nucleic Acids(2014) 3, e201. Aptamers are also commercially available (see, e.g.,SomaLogic, Inc., Boulder, Colo.). In certain embodiments, the presentinvention may utilize any aptamer containing any modification asdescribed herein.

Administration and Pharmaceutical Agents

It will be appreciated that administration of therapeutic entities inaccordance with the invention will be administered with suitablecarriers, excipients, and other agents that are incorporated intoformulations to provide improved transfer, delivery, tolerance, and thelike. A multitude of appropriate formulations can be found in theformulary known to all pharmaceutical chemists: Remington'sPharmaceutical Sciences (15th ed, Mack Publishing Company, Easton, Pa.(1975)), particularly Chapter 87 by Blaug, Seymour, therein. Theseformulations include, for example, powders, pastes, ointments, jellies,waxes, oils, lipids, lipid (cationic or anionic) containing vesicles(such as Lipofectin™), DNA conjugates, anhydrous absorption pastes,oil-in-water and water-in-oil emulsions, emulsions carbowax(polyethylene glycols of various molecular weights), semi-solid gels,and semi-solid mixtures containing carbowax. Any of the foregoingmixtures may be appropriate in treatments and therapies in accordancewith the present invention, provided that the active ingredient in theformulation is not inactivated by the formulation and the formulation isphysiologically compatible and tolerable with the route ofadministration. See also Baldrick P. “Pharmaceutical excipientdevelopment: the need for preclinical guidance.” Regul. ToxicolPharmacol. 32(2):210-8 (2000), Wang W. “Lyophilization and developmentof solid protein pharmaceuticals.” Int. J. Pharm. 203(1-2): 1-60 (2000),Charman W N “Lipids, lipophilic drugs, and oral drug delivery-someemerging concepts.” J Pharm Sci. 89(8):967-78 (2000), Powell et al.“Compendium of excipients for parenteral formulations” PDA J Pharm SciTechno 1. 52:238-311 (1998) and the citations therein for additionalinformation related to formulations, excipients and carriers well knownto pharmaceutical chemists. In practicing any of the methods disclosedherein, a suitable vector can be introduced to a cell or an embryo viaone or more methods known in the art, including without limitation,microinjection, electroporation, sonoporation, biolistics, calciumphosphate-mediated transfection, cationic transfection, liposometransfection, dendrimer transfection, heat shock transfection,nucleofection transfection, magnetofection, lipofection, impalefection,optical transfection, proprietary agent-enhanced uptake of nucleicacids, and delivery via liposomes, immunoliposomes, virosomes, orartificial virions. In some methods, the vector is introduced into anembryo by microinjection. The vector or vectors may be microinjectedinto the nucleus or the cytoplasm of the embryo. In some methods, thevector or vectors may be introduced into a cell by nucleofection.Provided herein are pharmaceutical formulations comprising singleagents, such as BCL-2 inhibitors, NF kappa B inhibitors, AMPK inhibitorsand/or mitochondrial electron transport chain (mETC) inhibitors (and/orpharmacologically active metabolites, salts, solvates and racematesthereof).

Agents may contain one or more asymmetric elements such as stereogeniccenters or stereogenic axes, e.g., asymmetric carbon atoms, so that thecompounds can exist in different stereoisomeric forms. These compoundscan be, for example, racemates or optically active forms. For compoundswith two or more asymmetric elements, these compounds can additionallybe mixtures of diastereomers. For compounds having asymmetric centers,it should be understood that all of the optical isomers and mixturesthereof are encompassed. In addition, compounds with carbon-carbondouble bonds may occur in Z- and E-forms; all isomeric forms of thecompounds are included in the present invention. In these situations,the single enantiomers (optically active forms) can be obtained byasymmetric synthesis, synthesis from optically pure precursors, or byresolution of the racemates. Resolution of the racemates can also beaccomplished, for example, by conventional methods such ascrystallization in the presence of a resolving agent, or chromatography,using, for example a chiral HPLC column.

Unless otherwise specified, or clearly indicated by the text, referenceto compounds useful in the therapeutic methods of the invention includesboth the free base of the compounds, and all pharmaceutically acceptablesalts of the compounds. The term “pharmaceutically acceptable salts”includes derivatives of the disclosed compounds, wherein the parentcompound is modified by making non-toxic acid or base addition saltsthereof, and further refers to pharmaceutically acceptable solvates,including hydrates, of such compounds and such salts. Examples ofpharmaceutically acceptable salts include, but are not limited to,mineral or organic acid addition salts of basic residues such as amines;alkali or organic addition salts of acidic residues such as carboxylicacids; and the like, and combinations comprising one or more of theforegoing salts. The pharmaceutically acceptable salts include non-toxicsalts and the quaternary ammonium salts of the parent compound formed,for example, from non-toxic inorganic or organic acids. For example,non-toxic acid salts include those derived from inorganic acids such ashydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, and nitric;other acceptable inorganic salts include metal salts such as sodiumsalt, potassium salt, and cesium salt; and alkaline earth metal salts,such as calcium salt and magnesium salt; and combinations comprising oneor more of the foregoing salts. In some embodiments, the salt is ahydrochloride salt.

Pharmaceutically acceptable organic salts include salts prepared fromorganic acids such as acetic, trifluoroacetic, propionic, succinic,glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic,maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic,mesylic, esylic, besylic, sulfanilic, 2-acetoxybenzoic, fumaric,toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic,HOOC(CH.sub.2).sub.nCOOH where n is 0-4; organic amine salts such astriethylamine salt, pyridine salt, picoline salt, ethanolamine salt,triethanolamine salt, dicyclohexylamine salt,N,N′-dibenzylethylenediamine salt; and amino acid salts such asarginate, asparginate, and glutamate, and combinations comprising one ormore of the foregoing salts.

The agents of the invention are administered in effective amounts. An“effective amount” is an amount sufficient to provide an observableimprovement over the baseline clinically observable signs and symptomsof the disorder treated with the combination.

The effective amount may be determined using known methods and willdepend upon a variety of factors, including the activity of the agents;the age, body weight, general health, gender and diet of the subject;the time and route of administration; and other medications the subjectis taking. Effective amounts may be established using routine testingand procedures that are well known in the art.

A physician or veterinarian having ordinary skill in the art can readilydetermine and prescribe the effective amount of the pharmaceuticalcomposition required. For example, the physician or veterinarian couldstart at doses lower than those required to achieve the desiredtherapeutic effect and gradually increase the dosage until the desiredeffect is achieved. In general, a suitable daily dose of will be thatamount of the compound that is the lowest dose effective to produce atherapeutic effect.

Generally, therapeutically effective doses of the compounds of thisinvention for a patient will range from about 0.0001 to about 1000 mgper kilogram of body weight per day, more preferably from about 0.01 toabout 50 mg per kg per day.

If desired, the effective daily dose of the active compound may beadministered as two, three, four, five, six or more sub-dosesadministered separately at appropriate intervals throughout the day,optionally, in unit dosage forms.

The agents may be administered using a variety of routes ofadministration known to those skilled in the art. The agents may beadministered to humans and other animals orally, parenterally,sublingually, by aerosolization or inhalation spray, rectally,intracisternally, intravaginally, intraperitoneally, bucally, ortopically in dosage unit formulations containing conventional nontoxicpharmaceutically acceptable carriers, adjuvants, and vehicles asdesired. Topical administration may also involve the use of transdermaladministration such as transdermal patches or ionophoresis devices. Theterm parenteral as used herein includes subcutaneous injections,intravenous, intramuscular, intrasternal injection, or infusiontechniques.

Administration of the combination includes administration of thecombination in a single formulation or unit dosage form, administrationof the individual agents of the combination concurrently but separately,or administration of the individual agents of the combinationsequentially by any suitable route. The dosage of the individual agentsof the combination may require more frequent administration of one ofthe agents as compared to the other agent in the combination. Therefore,to permit appropriate dosing, packaged pharmaceutical products maycontain one or more dosage forms that contain the combination of agents,and one or more dosage forms that contain one of the combinations ofagents, but not the other agent(s) of the combination. Administrationmay be concurrent or sequential.

The pharmaceutical formulations may additionally comprise a carrier orexcipient, stabilizer, flavoring agent, and/or coloring agent. Methodsof formulation are well known in the art and are disclosed, for example,in Remington: The Science and Practice of Pharmacy, Mack PublishingCompany, Easton, Pa., 19th Edition (1995). Pharmaceutical compositionsfor use in the present invention can be in the form of sterile,non-pyrogenic liquid solutions or suspensions, coated capsules,suppositories, lyophilized powders, transdermal patches or other formsknown in the art.

Injectable preparations, for example, sterile injectable aqueous oroleaginous suspensions may be formulated according to the known artusing suitable dispersing or wetting agents and suspending agents. Thesterile injectable preparation may also be a sterile injectablesolution, suspension or emulsion in a nontoxic parenterally acceptablediluent or solvent, for example, as a solution in 1,3 propanediol or 1,3butanediol. Among the acceptable vehicles and solvents that may beemployed are water, Ringer's solution, U.S.P. and isotonic sodiumchloride solution. In addition, sterile, fixed oils are conventionallyemployed as a solvent or suspending medium. For this purpose any blandfixed oil may be employed including synthetic mono or di glycerides. Inaddition, fatty acids such as oleic acid find use in the preparation ofinjectables. The injectable formulations can be sterilized, for example,by filtration through a bacterial-retaining filter, or by incorporatingsterilizing agents in the form of sterile solid compositions which canbe dissolved or dispersed in sterile water or other sterile injectablemedium prior to use.

In order to prolong the effect of a drug, it is often desirable to slowthe absorption of the drug from subcutaneous or intramuscular injection.This may be accomplished by the use of a liquid suspension ofcrystalline or amorphous material with poor water solubility. The rateof absorption of the drug then depends upon its rate of dissolutionwhich, in turn, may depend upon crystal size and crystalline form.Alternatively, delayed absorption of a parenterally administered drugform may be accomplished by dissolving or suspending the drug in an oilvehicle. Injectable depot forms are made by forming microencapsulematrices of the drug in biodegradable polymers such as polylactidepolyglycolide. Depending upon the ratio of drug to polymer and thenature of the particular polymer employed, the rate of drug release canbe controlled. Examples of other biodegradable polymers includepoly(orthoesters) and poly(anhydrides). Depot injectable formulationsmay also be prepared by entrapping the drug in liposomes ormicroemulsions, which are compatible with body tissues.

The pharmaceutical products can be released in various forms.“Releasable form” is meant to include instant release,immediate-release, controlled-release, and sustained-release forms.

“Instant-release” is meant to include a dosage form designed to ensurerapid dissolution of the active agent by modifying the normal crystalform of the active agent to obtain a more rapid dissolution.

“Immediate-release” is meant to include a conventional or non-modifiedrelease form in which greater than or equal to about 50% or morepreferably about 75% of the active agents is released within two hoursof administration, preferably within one hour of administration.

“Sustained-release” or “extended-release” includes the release of activeagents at such a rate that blood (e.g., plasma) levels are maintainedwithin a therapeutic range but below toxic levels for at least about 8hours, preferably at least about 12 hours, more preferably about 24hours after administration at steady-state. The term “steady-state”means that a plasma level for a given active agent or combination ofactive agents, has been achieved and which is maintained with subsequentdoses of the active agent(s) at a level which is at or above the minimumeffective therapeutic level and is below the minimum toxic plasma levelfor a given active agent(s).

The pharmaceutical products can be administrated by oral dosage form.“Oral dosage form” is meant to include a unit dosage form prescribed orintended for oral administration. An oral dosage form may or may notcomprise a plurality of subunits such as, for example, microcapsules ormicrotablets, packaged for administration in a single dose.

Compositions for rectal or vaginal administration are preferablysuppositories which can be prepared by mixing the compounds of thisinvention with suitable non irritating excipients or carriers such ascocoa butter, polyethylene glycol or a suppository wax which are solidat ambient temperature but liquid at body temperature and therefore meltin the rectum or vaginal cavity and release the active compound.

Solid dosage forms for oral administration include capsules, tablets,pills, powders, and granules. In such solid dosage forms, the activecompound is mixed with at least one inert, pharmaceutically acceptableexcipient or carrier such as sodium citrate or dicalcium phosphateand/or a) fillers or extenders such as starches, lactose, sucrose,glucose, mannitol, and silicic acid, b) binders such as, for example,carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidinone,sucrose, and acacia, c) humectants such as glycerol, d) disintegratingagents such as agar-agar, calcium carbonate, potato or tapioca starch,alginic acid, certain silicates, and sodium carbonate, e) solutionretarding agents such as paraffin, f) absorption accelerators such asquaternary ammonium compounds, g) wetting agents such as, for example,acetyl alcohol and glycerol monostearate, h) absorbents such as kaolinand bentonite clay, and i) lubricants such as talc, calcium stearate,magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate,and mixtures thereof. In the case of capsules, tablets and pills, thedosage form may also comprise buffering agents.

Solid compositions of a similar type may also be employed as fillers insoft and hard-filled gelatin capsules using such excipients as lactoseor milk sugar as well as high molecular weight polyethylene glycols andthe like.

The solid dosage forms of tablets, dragees, capsules, pills, andgranules can be prepared with coatings and shells such as entericcoatings and other coatings well known in the pharmaceutical formulatingart. They may optionally contain opacifying agents and can also be of acomposition that they release the active ingredient(s) only, orpreferentially, in a certain part of the intestinal tract, optionally,in a delayed manner. Examples of embedding compositions that can be usedinclude polymeric substances and waxes.

The active compounds can also be in micro-encapsulated form with one ormore excipients as noted above. The solid dosage forms of tablets,dragees, capsules, pills, and granules can be prepared with coatings andshells such as enteric coatings, release controlling coatings and othercoatings well known in the pharmaceutical formulating art. In such soliddosage forms the active compound may be admixed with at least one inertdiluent such as sucrose, lactose or starch. Such dosage forms may alsocomprise, as is normal practice, additional substances other than inertdiluents, e.g., tableting lubricants and other tableting aids such amagnesium stearate and microcrystalline cellulose. In the case ofcapsules, tablets and pills, the dosage forms may also comprisebuffering agents. They may optionally contain opacifying agents and canalso be of a composition that they release the active ingredient(s)only, or preferentially, in a certain part of the intestinal tract,optionally, in a delayed manner. Examples of embedding compositions thatcan be used include polymeric substances and waxes.

Liquid dosage forms for oral administration include pharmaceuticallyacceptable emulsions, microemulsions, solutions, suspensions, syrups andelixirs. In addition to the active compounds, the liquid dosage formsmay contain inert diluents commonly used in the art such as, forexample, water or other solvents, solubilizing agents and emulsifierssuch as ethyl alcohol, isopropyl alcohol, ethyl carbonate, EtOAc, benzylalcohol, benzyl benzoate, propylene glycol, 1,3 butylene glycol,dimethylformamide, oils (in particular, cottonseed, groundnut, corn,germ, olive, castor, and sesame oils), glycerol, tetrahydrofurfurylalcohol, polyethylene glycols and fatty acid esters of sorbitan, andmixtures thereof. Besides inert diluents, the oral compositions can alsoinclude adjuvants such as wetting agents, emulsifying and suspendingagents, sweetening, flavoring, and perfuming agents.

Dosage forms for topical or transdermal administration of a compound ofthis invention include ointments, pastes, creams, lotions, gels,powders, solutions, sprays, inhalants or patches. The active componentis admixed under sterile conditions with a pharmaceutically acceptablecarrier and any needed preservatives or buffers as may be required.Ophthalmic formulations, ear drops, and the like are also contemplatedas being within the scope of this invention.

The ointments, pastes, creams and gels may contain, in addition to anactive compound of this invention, excipients such as animal andvegetable fats, oils, waxes, paraffins, starch, tragacanth, cellulosederivatives, polyethylene glycols, silicones, bentonites, silicic acid,talc and zinc oxide, or mixtures thereof.

Compositions of the invention may also be formulated for delivery as aliquid aerosol or inhalable dry powder. Liquid aerosol formulations maybe nebulized predominantly into particle sizes that can be delivered tothe terminal and respiratory bronchioles.

Aerosolized formulations of the invention may be delivered using anaerosol forming device, such as a jet, vibrating porous plate orultrasonic nebulizer, preferably selected to allow the formation of anaerosol particles having with a mass medium average diameterpredominantly between 1 to 5 microns. Further, the formulationpreferably has balanced osmolarity ionic strength and chlorideconcentration, and the smallest aerosolizable volume able to delivereffective dose of the compounds of the invention to the site of theinfection. Additionally, the aerosolized formulation preferably does notimpair negatively the functionality of the airways and does not causeundesirable side effects.

Aerosolization devices suitable for administration of aerosolformulations of the invention include, for example, jet, vibratingporous plate, ultrasonic nebulizers and energized dry powder inhalers,that are able to nebulize the formulation of the invention into aerosolparticle size predominantly in the size range from 1 to 5 microns.Predominantly in this application means that at least 70% but preferablymore than 90% of all generated aerosol particles are within 1 to 5micron range. A jet nebulizer works by air pressure to break a liquidsolution into aerosol droplets. Vibrating porous plate nebulizers workby using a sonic vacuum produced by a rapidly vibrating porous plate toextrude a solvent droplet through a porous plate. An ultrasonicnebulizer works by a piezoelectric crystal that shears a liquid intosmall aerosol droplets. A variety of suitable devices are available,including, for example, AERONEB and AERODOSE vibrating porous platenebulizers (AeroGen, Inc., Sunnyvale, Calif.), SIDESTREAM nebulizers(Medic Aid Ltd., West Sussex, England), PARI LC and PARI LC STAR jetnebulizers (Pari Respiratory Equipment, Inc., Richmond, Va.), andAEROSONIC (DeVilbiss Medizinische Produkte (Deutschland) GmbH, Heiden,Germany) and ULTRAAIRE (Omron Healthcare, Inc., Vernon Hills, Ill.)ultrasonic nebulizers.

Compounds of the invention may also be formulated for use as topicalpowders and sprays that can contain, in addition to the compounds ofthis invention, excipients such as lactose, talc, silicic acid, aluminumhydroxide, calcium silicates and polyamide powder, or mixtures of thesesubstances. Sprays can additionally contain customary propellants suchas chlorofluorohydrocarbons.

Transdermal patches have the added advantage of providing controlleddelivery of a compound to the body. Such dosage forms can be made bydissolving or dispensing the compound in the proper medium. Absorptionenhancers can also be used to increase the flux of the compound acrossthe skin. The rate can be controlled by either providing a ratecontrolling membrane or by dispersing the compound in a polymer matrixor gel. The compounds of the present invention can also be administeredin the form of liposomes. As is known in the art, liposomes aregenerally derived from phospholipids or other lipid substances.Liposomes are formed by mono or multi lamellar hydrated liquid crystalsthat are dispersed in an aqueous medium. Any non-toxic, physiologicallyacceptable and metabolizable lipid capable of forming liposomes can beused. The present compositions in liposome form can contain, in additionto a compound of the present invention, stabilizers, preservatives,excipients, and the like. The preferred lipids are the phospholipids andphosphatidyl cholines (lecithins), both natural and synthetic. Methodsto form liposomes are known in the art. See, for example, Prescott(ed.), “Methods in Cell Biology,” Volume XIV, Academic Press, New York,1976, p. 33 et seq.

Screening Methods Modulating Agents

A further aspect of the invention relates to a method for identifying anagent capable of modulating one or more phenotypic aspects of a cell orcell population as disclosed herein, comprising: a) applying a candidateagent to the cell or cell population; b) detecting modulation of one ormore phenotypic aspects of the cell or cell population by the candidateagent, thereby identifying the agent. The phenotypic aspects of the cellor cell population that is modulated may be a gene signature, biomarkeror pathway specific to a cell type or cell phenotype or phenotypespecific to a population of cells (e.g., a BCL-2 inhibitor resistancephenotype). In certain embodiments, steps can include administeringcandidate modulating agents to cells, detecting changes in signatures,or identifying relative changes in cell populations which may comprisedetecting relative abundance of particular gene signatures. In certainembodiments, the one or more candidate agents increase expression,activity, and/or function of one or more BCL-2 inhibitor resistancegenes or gene products. In certain embodiments, the one or morecandidate agents increase expression, activity, and/or function of oneor more target genes or one or more products of one or more target geneswhich comprise inhibitors of the NF-Kappa B pathway, lymphoidtranscription factors and modulators, ubiquitination components, and/orpro-apoptotic BCL-2 family proteins. In certain embodiments, the one ormore candidate agents decrease expression, activity, and/or function ofone or more target genes or one or more products of one or more targetgenes which comprise energy-stress sensor signaling pathway components,a mitochondrial energy metabolism component, vesicle transport/autophagycomponents, ribosomal components, and/or ubiquitination components.

The term “modulate” broadly denotes a qualitative and/or quantitativealteration, change or variation in that which is being modulated. Wheremodulation can be assessed quantitatively—for example, where modulationcomprises or consists of a change in a quantifiable variable such as aquantifiable property of a cell or where a quantifiable variableprovides a suitable surrogate for the modulation—modulation specificallyencompasses both increase (e.g., activation) or decrease (e.g.,inhibition) in the measured variable. The term encompasses any extent ofsuch modulation, e.g., any extent of such increase or decrease, and maymore particularly refer to statistically significant increase ordecrease in the measured variable. By means of example, modulation mayencompass an increase in the value of the measured variable by at leastabout 10%, e.g., by at least about 20%, preferably by at least about30%, e.g., by at least about 40%, more preferably by at least about 50%,e.g., by at least about 75%, even more preferably by at least about100%, e.g., by at least about 150%, 200%, 250%, 300%, 400% or by atleast about 500%, compared to a reference situation without saidmodulation; or modulation may encompass a decrease or reduction in thevalue of the measured variable by at least about 10%, e.g., by at leastabout 20%, by at least about 30%, e.g., by at least about 40%, by atleast about 50%, e.g., by at least about 60%, by at least about 70%,e.g., by at least about 80%, by at least about 90%, e.g., by at leastabout 95%, such as by at least about 96%, 97%, 98%, 99% or even by 100%,compared to a reference situation without said modulation. Preferably,modulation may be specific or selective, hence, one or more desiredphenotypic aspects of a cell or cell population may be modulated withoutsubstantially altering other (unintended, undesired) phenotypicaspect(s).

The term “agent” broadly encompasses any condition, substance or agentcapable of modulating one or more phenotypic aspects of a cell or cellpopulation as disclosed herein. Such conditions, substances or agentsmay be of physical, chemical, biochemical and/or biological nature. Theterm “candidate agent” refers to any condition, substance or agent thatis being examined for the ability to modulate one or more phenotypicaspects of a cell or cell population as disclosed herein in a methodcomprising applying the candidate agent to the cell or cell population(e.g., exposing the cell or cell population to the candidate agent orcontacting the cell or cell population with the candidate agent) andobserving whether the desired modulation takes place.

Agents may include any potential class of biologically activeconditions, substances or agents, such as for instance antibodies,proteins, peptides, nucleic acids, oligonucleotides, small molecules, orcombinations thereof, as described herein.

In certain embodiments, this invention provides a method of developing abiologically active agent that modulates a cell signaling eventassociated with a disease gene. The method comprises contacting a testcompound with a cell comprising one or more vectors that driveexpression of one or more of a CRISPR enzyme, and a direct repeatsequence linked to a guide sequence; and detecting a change in a readoutthat is indicative of a reduction or an augmentation of a cell signalingevent associated with, e.g., a mutation in a disease gene contained inthe cell.

The methods of phenotypic analysis can be utilized for evaluatingenvironmental stress and/or state, for screening of chemical libraries,and to screen or identify structural, syntenic, genomic, and/or organismand species variations. For example, a culture of cells, can be exposedto an environmental stress, such as but not limited to heat shock,osmolarity, hypoxia, cold, oxidative stress, radiation, starvation, achemical (for example a therapeutic agent or potential therapeuticagent) and the like. After the stress is applied, a representativesample can be subjected to analysis, for example at various time points,and compared to a control, such as a sample from an organism or cell,for example a cell from an organism, or a standard value. By exposingcells, or fractions thereof, tissues, or even whole animals, todifferent members of the chemical libraries, and performing the methodsdescribed herein, different members of a chemical library can bescreened for their effect on phenotypes thereof simultaneously in arelatively short amount of time, for example using a high throughputmethod.

In some embodiments, screening of test agents involves testing acombinatorial library containing a large number of potential modulatorcompounds. A combinatorial chemical library may be a collection ofdiverse chemical compounds generated by either chemical synthesis orbiological synthesis, by combining a number of chemical “buildingblocks” such as reagents. For example, a linear combinatorial chemicallibrary, such as a polypeptide library, is formed by combining a set ofchemical building blocks (amino acids) in every possible way for a givencompound length (for example the number of amino acids in a polypeptidecompound). Millions of chemical compounds can be synthesized throughsuch combinatorial mixing of chemical building blocks.

In certain embodiments, the present invention provides for genesignature screening. The concept of signature screening was introducedby Stegmaier et al. (Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nature Genet. 36,257-263 (2004)), who realized that if a gene-expression signature wasthe proxy for a phenotype of interest, it could be used to find smallmolecules that effect that phenotype without knowledge of a validateddrug target. The signatures or pathways of the present invention may beused to screen for drugs that reduce the signature or pathway in cellsas described herein. The signature or pathways may be used for GE-HTS.In certain embodiments, pharmacological screens may be used to identifydrugs that are selectively toxic to cells having a signature.

The Connectivity Map (cmap) is a collection of genome-widetranscriptional expression data from cultured human cells treated withbioactive small molecules and simple pattern-matching algorithms thattogether enable the discovery of functional connections between drugs,genes and diseases through the transitory feature of commongene-expression changes (see, Lamb et al., The Connectivity Map: UsingGene-Expression Signatures to Connect Small Molecules, Genes, andDisease. Science 29 Sep. 2006: Vol. 313, Issue 5795, pp. 1929-1935, DOI:10.1126/science.1132939; and Lamb, J., The Connectivity Map: a new toolfor biomedical research. Nature Reviews Cancer January 2007: Vol. 7, pp.54-60). In certain embodiments, Cmap can be used to screen for smallmolecules capable of modulating a signature or pathway(s) of the presentinvention in silico.

Resistance Mechanisms

In certain embodiments, the invention provides methods and compositionsfor identifying genome-scale loss- (LOF) and gain-of-function (GOF)genetic modifiers of resistance to BCL-2 and BCL-2 family inhibitorssuch as but not limited to venetoclax. The invention provides screens tobe performed to identify target genes and resistance mechanisms in BCL-2family protein driven cancers. These target genes are identified, forexample, by contacting a cell expressing BCL-2 or BCL-2 family proteincell, e.g., a BCL-2 driven tumor cell, with a BCL-2 inhibitor andanother modulating agent and monitoring the effect on viability. Thesetarget genes In other embodiments, a cell expressing BCL-2 or BCL-2family protein, e.g., a BCL-2 driven tumor cell is contacted with aBCL-2 inhibitor or other modulating agent and the effect, if any, on theexpression of one or more signature genes or one or more products of oneor more signature genes is monitored.

In certain embodiments, the present invention provides forgenome-scale-loss (LOF) and gain-of-function (GOF) screens. Loss offunction screens may use CRISPR systems to knockout individual genes inindividual cells in a population of cells. For CRISPR methods, see, e.g.U.S. Pat. Nos. 9,840,713; 9,822,372; 9,790,490; 8,999,641; 8,993,233;8,945,839; 8,932,814; 8,906,616; 8,895,308; 8,889,418; 8,889,356;8,871,445; 8,865,406; 8,795,965; 8,771,945; 8,697,359 and US PatentPublication Nos. 20180274017; 20180235961; 20180171297; 20180127783;20180068062; 20170211142; 20160338326; 20160305934; 20160282354;20140335620; 20140287938; 20140273232; 20140273231; 20140256046;20140248702; 20140242700; 20140242699; 20140242664; 20140234972;20140227787; 20140186843; 20140179770; 20140179006 and 20140170753. Gainof function screens may use vectors that overexpress individual genes inindividual cells in a population of cells. In certain embodiments, thescreening method screens for cell viability. Cell viability may betested for by measuring enrichment of cells comprising either guidesequences or vectors specific to a target gene. Cell viability may betested for by measuring depletion of cells comprising either guidesequences or vectors specific to a target gene as compared to theoriginal proportion in the initial population. Thus, targets affectingviability may be detected.

In certain embodiments, genomewide screens according to the presentinvention may be performed in additional cell lines, in particularcancer cell lines. In certain embodiments, the cell is derived fromcells taken from a subject, such as a cell line. A wide variety of celllines for tissue culture models are known in the art. Examples of celllines include, but are not limited to, OCI-LY1, HT115, RPE1, C8161,CCRF-CEM, MOLT, mIMCD-3, NHDF, HeLa-S3, Huh1, Huh4, Huh7, HUVEC, HASMC,HEKn, HEKa, MiaPaCell, Panc1, PC-3, TF1, CTLL-2, C1R, Rat6, CV1, RPTE,A10, T24, J82, A375, ARH-77, Calu1, SW480, SW620, SKOV3, SK-UT, CaCo2,P388D1, SEM-K2, WEHI-231, HB56, TIB55, Jurkat, J45.01, LRMB, Bcl-1,BC-3, IC21, DLD2, Raw264.7, NRK, NRK-52E, MRC5, MEF, Hep G2, HeLa B,HeLa T4, COS, COS-1, COS-6, COS-M6A, BS-C-1 monkey kidney epithelial,BALB/3T3 mouse embryo fibroblast, 3T3 Swiss, 3T3-L1, 132-d5 human fetalfibroblasts; 10.1 mouse fibroblasts, 293-T, 3T3, 721, 9L, A2780,A2780ADR, A2780cis, A172, A20, A253, A431, A-549, ALC, B16, B35, BCP-1cells, BEAS-2B, bEnd.3, BHK-21, BR 293, BxPC3, C3H-10T1/2, C6/36,Cal-27, CHO, CHO-7, CHO-IR, CHO-K1, CHO-K2, CHO-T, CHO Dhfr −/−,COR-L23, COR-L23/CPR, COR-L23/5010, COR-L23/R23, COS-7, COV-434, CML T1,CMT, CT26, D17, DH82, DU145, DuCaP, EL4, EM2, EM3, EMT6/AR1,EMT6/AR10.0, FM3, H1299, H69, HB54, HB55, HCA2, HEK-293, HeLa,Hepa1c1c7, HL-60, HMEC, HT-29, Jurkat, JY cells, K562 cells, Ku812,KCL22, KG1, KYO1, LNCap, Ma-Mel 1-48, MC-38, MCF-7, MCF-10A, MDA-MB-231,MDA-MB-468, MDA-MB-435, MDCK II, MDCK II, MOR/0.2R, MONO-MAC 6, MTD-1A,MyEnd, NCI-H69/CPR, NCI-H69/LX10, NCI-H69/LX20, NCI-H69/LX4, NIH-3T3,NALM-1, NW-145, OPCN/OPCT cell lines, Peer, PNT-1A/PNT 2, RenCa, RIN-5F,RMA/RMAS, Saos-2 cells, Sf-9, SkBr3, T2, T-47D, T84, THP1 cell line,U373, U87, U937, VCaP, Vero cells, WM39, WT-49, X63, YAC-1, YAR, andtransgenic varieties thereof. Cell lines are available from a variety ofsources known to those with skill in the art (see, e.g., the AmericanType Culture Collection (ATCC) (Manassas, Va.)).

Kits

The present invention also comprises a kit with a detection reagent thatbinds to one or more signature nucleic acids. Also provided by theinvention is an array of detection reagents, e.g., oligonucleotides thatcan bind to one or more signature nucleic acids. Suitable detectionreagents include nucleic acids that specifically identify one or moresignature nucleic acids by having homologous nucleic acid sequences,such as oligonucleotide sequences, complementary to a portion of thesignature nucleic acids packaged together in the form of a kit. Theoligonucleotides can be fragments of the signature genes. For example,the oligonucleotides can be 200, 150, 100, 50, 25, 10 or fewernucleotides in length. The kit may contain in separate container orpackaged separately with reagents for binding them to the matrix),control formulations (positive and/or negative), and/or a detectablelabel such as fluorescein, green fluorescent protein, rhodamine, cyaninedyes, Alexa dyes, luciferase, radio labels, among others. Instructions(e.g., written, tape, VCR, CD-ROM, etc.) for carrying out the assay maybe included in the kit. The assay may for example be in the form of aNorthern hybridization or DNA chips or a sandwich ELISA or any othermethod as known in the art. Alternatively, the kit contains a nucleicacid substrate array comprising one or more nucleic acid sequences.

Although the present invention and its advantages have been described indetail, it should be understood that various changes, substitutions andalterations can be made herein without departing from the spirit andscope of the invention as defined in the appended claims.

Further embodiments are illustrated in the following Examples which aregiven for illustrative purposes only and are not intended to limit thescope of the invention.

EXAMPLES Example 1—Loss of Function (LOF) and Gain of Function (GOF)Screens for Venetoclax Resistance

The B-cell lymphoma 2 (BCL-2) family includes both pro- andanti-apoptotic proteins that govern mitochondrial apoptosis. Inleukemias and solid cancers, apoptosis dysregulation can result fromoverexpression of the anti-apoptotic BCL-2 protein that can sequestercertain pro-apoptotic BH3-only proteins (BIM, BID) to avoid BAX and BAKoligomerization and subsequent mitochondrial outer membranepermeabilization. Within B cell tumors, BCL-2 dysregulation commonlyarises from genetic abnormalities such as the translocationt(14;18)(q32;q21), which places BCL2 under the control of IGH promoter(in follicular lymphoma)^(1,2); or focal deletion of chromosome 13(del[13q14]), which leads to loss of a negative regulatory microRNA ofBCL-2, miR-15a/16-1 (in chronic lymphocytic leukemia (CLL))³. Thus,BCL-2 has been a rational therapeutic target in lymphoid cancers.

Venetoclax (formerly ABT-199/GDC-0199) is a first-in-class BCL-2inhibitor and has been recently FDA-approved for the treatment of CLL⁴.It displaces pro-apoptotic BH3-only proteins from BCL-2, allowing themto activate the mitochondrial pore-forming proteins BAK or BAX⁵. Despiteits potent clinical activity in CLL cases failing control withchemotherapy regimens such as those carrying disruption of TP53⁴,disease progression on venetoclax is becoming an increasing therapeuticchallenge^(6,7).

Here, Applicants aimed to uncover the determinants of venetoclaxresistance by using genome-scale survival screens, phenotypiccharacterization of venetoclax-resistant lymphoid cell lines, andexome-wide sequencing-based analysis of drug-resistant cell lines andprimary CLL samples. The complementary analyses revealed venetoclaxresistance to involve not only modulation of BCL2-family members, butalso broader changes in mitochondrial metabolism.

Genome-scale screens identify BCL-2 family members and novel candidatedrivers of venetoclax resistance. To systematically identify drivers ofresistance to venetoclax, Applicants performed parallel genome-scaleloss-of-function (LOF) and gain-of-function (GOF) genetic modifierscreens, using the BCL-2-driven OCI-Ly1 lymphoma cell line (FIG. 1 a ).For the LOF screen, OCI-Ly1 cells, modified to stably express Cas9, wereinfected with the Brunello lentiviral library of 76,441 sgRNAs targeting19,114 genes and 1,000 control sgRNAs⁸, and treated with venetoclax (orDMSO, as control) for 14 days (FIG. 7 a ). To evaluate changes in sgRNArepresentation due to drug treatment, genomic DNA from viable cells onday 14 underwent sequencing for detection of the sgRNA sequences.Although average sgRNA representation was overall decreased in thetransduced cells treated with venetoclax compared to duplicate sets ofuntreated and DMSO-treated transduced cells, a clear subset ofvenetoclax-treated transduced cells were enriched (FIG. 1 b ). Byanalysis with the STARS software (v1.3, Broad Institute)⁸, sgRNAscorresponding to 11 genes were consistently enriched over 2 replicatesafter drug treatment compared to DMSO after 14 days (STARS score >4;FIG. 1 d , Table 1), with high consistency in the changes inrepresentation amongst the 4 sgRNAs per gene (FIG. 7 b ). Notsurprisingly, four of 11 knocked-out genes encoded pro-apoptoticBCL-2-family proteins (PMAIP1, BAX, BAK1, BCL-2L11). Moreover, the levelof representation by sgRNAs corresponding to the other BCL-2 membersmatched their known functions as either pro- or anti-apoptotic familymembers (FIG. 7 c ). Notably, the other 7 candidate hit genes were notBCL-2-family members, but were involved in pathways highly relevant tolymphoid biology. These included NFKBIA, an inhibitor of the NF-Kappa Bpathway, lymphoid transcription factors and modulators (IKZF5, ID3,EP300, NFIA), and components of the processes of ubiquitination (OTUD5,UBR5). Several of the discovered genes are recurrently mutated in B cellmalignancies: UBR5 in 18% of mantle cell lymphomas⁹, ID3 in 68% ofBurkitt lymphomas¹⁰, and NFKBIA in 20% of Hodgkin lymphomas¹¹.

In an analogous fashion, Applicants performed a GOF screen by using agenome-scale library including 17,255 barcoded ORFs encoding 12,952unique proteins with at least 99% nucleotide and protein match tocomprehensively identify genes that confer resistance to venetoclax whenoverexpressed in OCI-Ly1 cells. A total of 71 ORFs (arising from 70genes) had a log₂ fold change (LFC) greater than 2 (FIG. 1 e , Table 2).The top four genes that generated resistance when overexpressed werethose encoding known anti-apoptotic proteins (BCL2L1, BCL2L2, BCL2,MCL1). Included among the top 50 genes of the screen were components ofthe energy-stress sensor PKA/AMPK signaling pathway (ADIPOQ, PRKAR2B,PRKAA2), mitochondrial energy metabolism (SLC25A3) or vesicletransport/autophagy (RNF26, DNM2, PRKD2, ATG5), ribosomal proteins(RPL17, RPS4Y1, RPS15A), and components of ubiquitination (OTUD6A,FBXO9, USP54) (FIG. 1 e ).

To confirm the LOF screen results, Applicants generated single-geneknockout OCI-Ly1 cell lines for each of the 11 hits (2 cell lines pergene, generated from the 2 most efficient sgRNAs per gene). Applicantsalso generated control lines corresponding to 2 non-targeting sgRNAs andfor 2 sgRNAs targeting TP53 (FIG. 7 d ). From the GOF screen, Applicantsdetected two protein kinases components from related signaling pathways(PRKAR2B, PRKAA2). Applicants hence prioritized the generation of 2OCI-Ly1 cell lines, one with overexpression of the regulatory subunit ofcAMP-dependent protein kinase (protein kinase A, PKA) encoded by PRKAR2Band the other, of the catalytic subunit of the AMP-activated proteinkinase (AMPK) encoded by PRKAA2, both of which are key regulators ofcellular metabolism (FIG. 7 e )^(12,13).

Across the individual knockout cell lines, Applicants observed adecreased sensitivity to venetoclax with median increase in IC50 of2.1-fold (range, 1.3- to 13.8-fold; P<0.05, extra-sum-of-squares F test)compared to cell lines transduced with 2 non-targeting control sgRNAs(FIG. 1 f , FIG. 7 f ). Moreover, all generated knockout andoverexpression lines showed increased cumulative growth over 10 days ofin vitro venetoclax treatment (FIG. 1 h ). Exposure of the knockout celllines to venetoclax increased the degree of depletion of the targetedprotein and enriched the frequency of frameshift indels generated by theintroduction of sgRNAs into the cell lines (FIG. 7 d, g , Table 3).Altogether, these results confirmed the on-target effects of the sgRNAsand the ORFs identified in the analyses of the parallel genome-widescreens.

Determining the Signature of Venetoclax Resistance

In complementary experiments, Applicants characterized thetranscript-level and protein expression profiles of avenetoclax-resistant cell line (OCI-Ly1-R, IC50 1 μM), generated throughchronic in vitro drug exposure of the parental (OCI-Ly1-S, IC50 4 nM)cells (FIG. 2 a ). By RNA-sequencing (RNA-Seq) of the resistant andsensitive cell lines, Applicants identified 19 upregulated and 28downregulated genes (adjusted P-value <0.05; |LFC|>2) (FIG. 8 a , Table3). Comparison of the transcriptomes and the proteomes (identified viamass spectrometry-based proteomics, see Methods) of the OCI-Ly1-S andOCI-Ly1-R cells revealed close concordance across these two platforms(R²=0.4, all genes; R²=0.8, restricted to differentially expressedgenes; FIG. 2 b ), with 14 upregulated and 13 downregulated proteins(adjusted P-value <0.05, |LFC|>2) (Tables 3 and 4).

When evaluated at the gene-level, MCL-1 emerged as the onlysignificantly and coordinately deregulated transcript and protein thatalso overlapped with the gene hits from the genome-scale screens (FIG. 2b ). MCL-1 overexpression has been previously reported in thecharacterizations of cancer cell lines rendered resistant to BCL-2inhibition and has been described to sequester the pro-apoptotic BIMprotein^(14,15). Applicants confirmed the relative increase in proteinexpression of MCL-1 in OCI-Ly1-R cells compared to OCI-Ly1-S cells (FIG.2 c ), and observed in vitro synergy between venetoclax and the MCL-1inhibitor S63845¹⁶ on OCI-Ly1-S cells (combination index <1, FIG. 2 d-e). MCL-1 inhibition could furthermore restore venetoclax sensitivity tothe OCI-Ly1-R cells (FIG. 2 f ). These results confirm a key role ofMCL-1 overexpression in mediating venetoclax resistance.

In contrast to gene-level analysis, pathway-level geneset enrichmentanalysis (GSEA) based on RNAseq data revealed 35 significantly enrichedpathways (nominal P-value <0.05, FDR <0.25) (Table 5). Consistent withpathway-level results from Applicants' gain- and loss-of-functionscreens, positively regulated pathways included lymphoid differentiationand chromatin maintenance, while top negatively regulated pathwaysrelated to metabolism and the endoplasmic reticulum (nominal P-value<0.002, FDR <0.9) (FIG. 2 g ). In addition, as observed in Applicants'functional genomics screens, the most coordinately upregulatedtranscripts and proteins (Tables 3 and 4) originated from genes criticalto cellular metabolism (AOX1, GLUL, PAPSS1, GATM, TSTD1, GALM, FBP1)(FIG. 2 b ). GLUL encodes the glutamine synthetase that plays a role incell survival¹⁷; FBP1 encodes the fructose-bisphosphatase 1 and itsrepression was previously shown to efficiently promote glycolysis¹⁸. Theother upregulated transcripts/proteins highlighted other mechanisms ofpotential interest, including cell cycle regulation (CDK6, CDKN1A[encoding p21], TT39C), B-cell biology (DOCK10) as well as autophagy(DENND3, OPTN) and reactive oxygen species generation (CYBB).

Metabolic reprogramming plays a critical role in the resistance to BCL-2inhibition. Given the dysregulation of proteins critical to AMPKsignaling and metabolism in both the GOF screen and in OCI-Ly1-R cells,Applicants hypothesized that metabolic reprogramming also contributes toresistance of malignant B cells to venetoclax. A recent genome-wideCRISPR screen identified AMPK subunits as regulators of oxidativephosphorylation¹⁹. Applicants therefore evaluated mitochondrialrespiration by measuring the oxygen consumption rate over time followingthe addition of mitochondrial electron transplant chain (mETC)modulators (Seahorse assay, Methods). Compared to OCI-Ly1-S cells,OCI-Ly1-R cells demonstrated markedly higher rate of oligomycinsensitive oxygen consumption, suggesting a state of higher oxidativephosphorylation (OXPHOS) (FIG. 3 a , P<0.0001). Applicants also notedthe OCI-Ly1-R cells to have higher levels of reactive oxygen species andhigher mitochondrial membrane potential (FIG. 3 b , FIG. 8 b ).Applicants ascertained that this was not a result of an increased massof mitochondria per cell in the resistant cells, since the quantity ofmitochondrial DNA was equivalent between the drug-resistant and-sensitive cells (FIG. 3 c ). Applicants found that OCI-Ly1-R alsoexhibited a higher basal level of glycolysis, as assessed byextracellular acidification rate (ECAR) (FIG. 3 e , P<0.0001).

To investigate whether venetoclax directly affects cellular energymetabolism, Applicants measured oxygen consumption of the cell linesfollowing venetoclax exposure. Consistent with impairment of OXPHOS byvenetoclax, Applicants observed both an immediate decrease in oxygenconsumption (by 2-fold within 20 minutes after drug exposure) and animmediate increase in ECAR following venetoclax in the OCI-Ly1-S cells,but not in the OCI-Ly1-R cells (FIGS. 3 d and 3 e , P<0.0001). Theimpact on OXPHOS was apoptosis-independent, as it was not fullyprevented with the caspase inhibitor zVAD.

In line with these findings, the AMPK inhibitor dorsomorphin (compoundC) and drugs targeting the mETC (i.e. oligomycin, antimycin) synergizedwith venetoclax in the OCI-Ly1-S cells (combination index <1, FIG. 3 f ,FIG. 8 c ). Additionally, dorsomorphin and oligomycin could each restoresensitivity to venetoclax in the OCI-Ly1-R cells (FIG. 3 g ).Altogether, these results show that venetoclax not only induces celldeath through caspase activation but also induces rapid changes inmetabolism. Furthermore, multiple lines of evidence suggest thatresistance to this compound results at least in part from metabolicreprogramming.

To define the possible mechanisms by which the candidate hit genesidentified from the survival screens were related to venetoclaxresistance, Applicants first evaluated MCL-1 expression in therespective knockout and overexpression cell lines. None of 14 testedcell lines demonstrated elevated MCL-1 levels (FIG. 5 a ) nor clearsensitivity to MCL-1 inhibition (FIG. 5 b ), suggesting their engagementin alternative mechanisms of resistance to venetoclax. Transcriptomeprofiling of each of the knockout cell lines corresponding to 6non-BCL-2 family member gene candidates revealed the knockout line ofthe lymphoid transcription factor ID3 as the most similar to theOCI-Ly1-R cell line (FIG. 5 c ). Shared were transcripts involved inlymphoid signaling (PLCL2, KCNA3, PAG1) or transcription (XBP1),metabolism (CYP2U1, CYBB), apoptosis (TNFRSF21) and Ras signaling(DIRAS1, GNG7, RAPGEF5). Of note, ID2 (closely related to ID3) wasamongst the coordinately deregulated transcripts and proteins in theOCI-Ly1-R cell line (indicated in FIG. 2 b ). Recent work has implicatedlymphoid transcriptional factors as metabolic gatekeepers²⁰ and the IDfamily of genes has been previously suggested to regulate the functionof specific mETC complexes, thereby modulating mitochondrialOXPHOS^(21,22).

In keeping with these reports, PRKAR2B, which Applicants had previouslyuncovered in the GOF screen, was the most significantly upregulated geneof the ID3 knockout cell line (adjusted P-value <0.05, LFC>2; FIG. 5 d). Other strongly dysregulated transcripts fell in the mTOR pathway(e.g. DEPTOR [DEP domain-containing mTOR-interacting protein] gene), andthe pathways of Ras signaling (DIRAS1, RHOB, GNG7, SYNGAP1 genes) andB-cell differentiation (EGR1, EGR2). Conversely, overexpression ofPRKAR2B (encoding a PKA subunit) or PRKAA2 (encoding the catalytic AMPKsubunit) led to repression of both ID3 and ID2 genes (FIG. 5 e ). Singlecell clones derived from the ID3 knockout cell line (FIG. 8 d ) weremore sensitive to the combination of venetoclax and either dorsmorphinor oligomycin than control cells (FIG. 5 f ), suggesting AMPK dependencyand metabolic adaptation related to ID3 repression. PKA and AMPKoverexpressing cells demonstrated similar increased sensitivity to thecombination of venetoclax and oligomycin (FIG. 8 e ). Thus, metabolicdysregulation through ID3 links the findings of Applicants'complementary GOF and LOF screens.

Venetoclax resistance in CLL patients is associated with clonal shifts.To determine if there was a genetic basis for the observed drugresistance in the OCI-Ly1-R cells, Applicants compared the results ofwhole-exome sequencing (WES) of DNA isolated from the OCI-Ly1-R andOCI-Ly1-S cell lines. No non-silent somatic single nucleotide variants(sSNVs) overlapping with Applicants' screen data were identified exceptin BCL2, a common target of aberrant somatic hypermutation frequentlyaffected in B lymphomas and most B-cell lines.²¹ However, none involvedBH3 domain residues previously linked to venetoclax resistance in celllines²⁴. Regarding somatic copy number variations (sCNVs), a clearregion was amplified on chromosome 1q23 (amp[1q]) in the OC-Ly1-R butnot in the OCI-Ly-S cells. No other differential sCNVs were identified(FIG. 6 a , FIG. 9 a ).

Similarly, in a WES-based analysis of paired CLL DNA samples isolatedfrom 6 patients at treatment initiation and at the time of progressionon venetoclax (median time to relapse 16.4 months [range, 5.1-22.8].

TABLE 6 Venetoclax resistance in CLL patients. Pre-venetoclax baselineTime to Age (y) cytogenetic IGHV Daily Best progression Patient GenderPrior therapy features status dose response (months) 1 70 F FCRdel(17p), ND 400 mg PR 22.8 del(11q), CK 2 80 M FCR, BR, del(17p), UM400 mg PR 7.1 R-MP, tri 12, CK alemtuzumab 3 64 F FCR del(17p) UM 400 mgPR 16.4 4 54 F FCR, R-MP del(17p), ND 400 mg PR 5.1 del(11q), tri 12,del(13q), CK 5 66 M FR, BR, normal FISH UM 400 mg PR 8.2 ibrutinib,idelalisib 6 46 M FCR, BTKi normal FISH UM 1200 PR 22.8 (AVL292) mg then400 mg

TABLE 7 Sample Characteristics Pre-venetoclax Post-venetoclax GermlinePatient sample sample sample 1 Marrow MCs Marrow MCs saliva 2 PBMCsPBMCs saliva 3 FFPE marrow FFPE marrow absent biopsy biopsy 4 FFPEmarrow Fresh lymph saliva biopsy node biopsy 5 PBMCs PBMCs saliva 6PBMCs PBMCs Saliva Mononuclear cells were isolated with Ficoll/Hypaquedensity-gradient centrifugation, cryopreserved with 10% DMSO and storedin vapor-phase liquid nitrogen until the time of analysis. MCs,mononuclear cells; PB, peripheral blood; FFPE, formalin-fixed,paraffin-embedded.

Applicants did not identify any sSNVs in BCL2 itself at baseline or atprogression, nor in any coding region of BCL-2 family members, despitethe observation of marked clonal shifts in all patients (FIG. 6 b-c ,Methods). No differences in the median mutation rate between baselineand relapse samples across patients were observed (FIG. 9 b ;Mann-Whitney two-tailed P=0.40). Numerous instances of shifting cancercell fractions (CCF) of subclones with ATM, TP53 or SF3B1 mutation, evenof distinct subclones with differing mutated alleles of the same genewithin an individual (FIG. 6 c , FIG. 9 c-d ) were observed, but nosSNVs of known CLL driver mutations were consistently selected withresistance.

The shifts in sCNVs were more revealing. In both Patients 1 and 2,resistance was associated with a large expansion of a subclone carryinga combination of recurrent cancer alterations comprised of del(17p)[TP53], amp(8q) [MYC] and del(8p) [encompasses the TRAIL receptor] (FIG.5 b , FIGS. 9 b and 10). Applicants previously described enrichment ofdel(8p) in the setting of resistance to the targeted BTK inhibitoribrutinib²⁵, and BCL-2 inhibition has been shown to sensitize humancancer cells to TRAIL-induced apoptosis by inducing the expression ofits receptor²⁶. Applicants' finding of amp(8q) (MYC locus) together withthe recently reported del(9p) (CDKN2A/B locus) in venetoclax resistantpatients²⁷, supports the idea that changes in cell cycle regulation areimportant in resistance. Applicants noted that Patients 1 and 2 both hadtruncal SF3B1 and TP53 mutations, suggesting the selection of thiscomplex subclone as a common trajectory (FIG. 6 b , FIG. 9 c ). In linewith the cell line data, Applicants observed growing subclones withamp(1q) in 4 of 6 cases (Patients 1, 2, 3 and 4; FIG. 6 b , FIG. 9 d andFIG. 10 ). Applicants confirmed a common region of gain of 8 Mb whenoverlapping cell lines and Patients 1, 2, and 3 data. Contained withinthis amplified region were several genes of interest including MCL1 andPRKAB2, encoding the regulatory subunit of AMPK (FIG. 6 d ). In linewith cell line data, these results support the involvement of MCL-1 andAMPK in patients.

TABLE 8 Patient sSNVs and sCNVs Hugo_Symbol Patient ID ChromosomeStart_position End_position Variant_Classification Unknown MDA-1 205049934 5049934 IGR AATK MDA-1 17 79100307 79100307 Silent ABCD4 MDA-114 74769649 74769649 5′UTR ABCF1 MDA-1 6 30557939 30557939 Silent ABTB2MDA-1 11 34189512 34189512 Missense_Mutation ACAD10 MDA-1 12 112140025112140025 Missense_Mutation ACAT1 MDA-1 11 108013201 108013201 SilentACD MDA-1 16 67693054 67693054 Intron ACIN1 MDA-1 14 23547434 23547434Silent ACKR3 MDA-1 2 237489447 237489447 Silent ADC MDA-1 1 3356377133563771 Missense_Mutation ADORA3 MDA-1 1 112031338 112031338Missense_Mutation AHNAK2 MDA-1 14 105418236 105418236 Intron ALG8 MDA-111 77850647 77850647 5′UTR ANO9 MDA-1 11 418786 418786 Silent ARMC12MDA-1 6 35716408 35716408 Missense_Mutation ARSK MDA-1 5 9490182694901826 Missense_Mutation ASAP2 MDA-1 2 9458703 9458703 Silent ATP13A1MDA-1 19 19766380 19766380 Silent ATP6V0B MDA-1 1 44443534 44443534Intron ATP6V0B MDA-1 1 44443854 44443854 3′UTR ATP8B4 MDA-1 15 5022334550223345 Missense_Mutation BFSP1 MDA-1 20 17474966 17474966Missense_Mutation C15orf27 MDA-1 15 76484383 76484383 Silent C15orf39MDA-1 15 75500385 75500385 Missense_Mutation C16orf45 MDA-1 16 1567703315677033 Intron C19orf18 MDA-1 19 58469962 58469962 3′UTR C21orf58 MDA-121 47737231 47737231 5′UTR C2CD2 MDA-1 21 43327136 43327136Missense_Mutation CACNA1S MDA-1 1 201008831 201008831 3′UTR CAD MDA-1 227438370 27438370 5′Flank CADM3 MDA-1 1 159169596 159169596 SilentCAPRIN2 MDA-1 12 30866733 30866733 Missense_Mutation CASP5 MDA-1 11104879640 104879640 Intron CCDC57 MDA-1 17 80146161 80146161Missense_Mutation CDC42BPB MDA-1 14 103412888 103412888Missense_Mutation CDK6 MDA-1 7 92462649 92462649 5′UTR CENPT MDA-1 1667859170 67859170 IGR CEPT1 MDA-1 1 111724875 111724875Missense_Mutation CES4A MDA-1 16 67034915 67034915 Intron CFTR MDA-1 7117171082 117171082 Missense_Mutation CHRNA4 MDA-1 20 61975048 61975048IGR CHRNA4 MDA-1 20 61977100 61977100 3′UTR CHRNB3 MDA-1 8 4258727642587276 Missense_Mutation CHTF18 MDA-1 16 839639 839639Missense_Mutation CLTB MDA-1 5 175843297 175843297 Missense_MutationCOL18A1 MDA-1 21 46925155 46925155 Silent COMMD4 MDA-1 15 7563245175632451 3′UTR CSMD2 MDA-1 1 34192274 34192274 Missense_Mutation CTBP1MDA-1 4 1222131 1222131 Splice_Site CYP1A2 MDA-1 15 75047364 75047364Missense_Mutation DEFA4 MDA-1 8 6793444 6793444 3′UTR DEFB1 MDA-1 86728155 6728155 3′UTR DIABLO MDA-1 12 122710543 122710543Missense_Mutation DOPEY2 MDA-1 21 37581028 37581028 Silent DST MDA-1 656472185 56472185 Missense_Mutation DYNC1H1 MDA-1 14 102493523 102493523Silent DYSF MDA-1 2 71778274 71778274 Silent EIF2AK4 MDA-1 15 4028436540284365 Intron ENPEP MDA-1 4 111469387 111469387 Missense_MutationEP300 MDA-1 22 41575101 41575101 3′UTR EPHB4 MDA-1 7 100410369 100410369Splice_Site ERCC6 MDA-1 10 50732137 50732137 Missense_Mutation ESYT1MDA-1 12 56532010 56532010 Missense_Mutation EXPH5 MDA-1 11 108384034108384034 Missense_Mutation EXPH5 MDA-1 11 108381304 108381304Missense_Mutation FAM111B MDA-1 11 58892455 58892455 Silent FAM65B MDA-16 24936164 24936164 5′UTR FAM71B MDA-1 5 156593004 156593004Missense_Mutation FBXL16 MDA-1 16 745861 745861 Silent FLNB MDA-1 358109215 58109215 Silent FLYWCH2 MDA-1 16 2946755 2946755Missense_Mutation FNBP4 MDA-1 11 47788853 47788853 5′UTR FNBP4 MDA-1 1147776121 47776121 Missense_Mutation FZD8 MDA-1 10 35928269 359282693′UTR GCC1 MDA-1 7 127223259 127223259 Silent GNA15 MDA-1 19 31486503148650 Silent GPR144 MDA-1 9 127230406 127230406 Silent GRIP1 MDA-1 1266742963 66742963 Missense_Mutation HAVCR1 MDA-1 5 156482307 156482307Missense_Mutation HGD MDA-1 3 120393783 120393783 Silent HNRNPM MDA-1 198528518 8528518 Missense_Mutation HNRNPUL2 MDA-1 11 62489302 62489302Missense_Mutation HSD17B12 MDA-1 11 43876811 43876811 3′UTR HSDL2 MDA-19 115232876 115232876 3′UTR IGHM MDA-1 14 106322331 106322331 RNA INTS6MDA-1 13 51938412 51938412 IGR IQGAP1 MDA-1 15 90931555 90931555 5′UTRITPR1 MDA-1 3 4687151 4687151 Silent JMJD1C MDA-1 10 64927838 64927838Silent JMJD1C MDA-1 10 64974886 64974886 Missense_Mutation JPH3 MDA-1 1687678135 87678135 Silent JPH4 MDA-1 14 24040505 24040505Missense_Mutation KDELR2 MDA-1 7 6505949 6505949 Silent KIAA0020 MDA-1 92827078 2827078 Missense_Mutation KIAA1109 MDA-1 4 123131078 123131078Splice_Site KLF11 MDA-1 2 10187822 10187822 Missense_Mutation KNTC1MDA-1 12 123087655 123087655 Intron KRT35 MDA-1 17 39637094 39637094Missense_Mutation KRTAP24-1 MDA-1 21 31654701 31654701 Missense_MutationLINC00207 MDA-1 22 44966400 44966400 lincRNA LRIG2 MDA-1 1 113661942113661942 Missense_Mutation LRRC16B MDA-1 14 24526377 24526377Splice_Site LSM14B MDA-1 20 60705322 60705322 Missense_Mutation MB21D2MDA-1 3 192516813 192516813 Missense_Mutation MCF2L2 MDA-1 3 182923971182923971 Missense_Mutation MED12L MDA-1 3 151101587 151101587 SilentMIR1207 MDA-1 8 129061462 129061462 RNA MLXIP MDA-1 12 122618415122618415 Missense_Mutation MSLNL MDA-1 16 825490 825490Missense_Mutation MST1 MDA-1 3 49723393 49723393 Missense_Mutation MT1LMDA-1 16 56651379 56651379 RNA MT3 MDA-1 16 56624854 56624854Missense_Mutation MTHFD2L MDA-1 4 75091057 75091057 Missense_MutationMUC17 MDA-1 7 100675393 100675393 Silent MYO10 MDA-1 5 16701732 16701732Missense_Mutation NARS MDA-1 18 55273918 55273918 Missense_MutationNCBP1 MDA-1 9 100409817 100409817 Missense_Mutation NCOR2 MDA-1 12124862913 124862913 Silent NDUFB10 MDA-1 16 2013040 2013040 IGR NEK9MDA-1 14 75568358 75568358 Splice_Site NEU4 MDA-1 2 242757729 242757729Silent NFATC4 MDA-1 14 24836781 24836781 Intron NKX2-6 MDA-1 8 2356391223563912 Missense_Mutation NNT MDA-1 5 43651894 43651894Missense_Mutation NPAT MDA-1 11 108093355 108093355 5′UTR NRXN1 MDA-1 250574367 50574367 Intron NUMBL MDA-1 19 41174010 41174010Missense_Mutation OGFOD2 MDA-1 12 123463489 123463489 Missense_MutationORAI3 MDA-1 16 30965479 30965479 Intron OTUD7B MDA-1 1 149907209149907209 IGR OXSR1 MDA-1 3 38207236 38207236 De_novo_Start_OutOfFramePAFAH1B3 MDA-1 19 42806354 42806354 Intron PALD1 MDA-1 10 7228581472285814 Missense_Mutation PAPPA MDA-1 9 118997737 118997737 SilentPCDHGB3 MDA-1 5 140778157 140778157 Intron PCID2 MDA-1 13 113833282113833282 Missense_Mutation PDE6A MDA-1 5 149276036 149276036 SilentPI4KA MDA-1 22 21165309 21165309 Silent PIK3C2A MDA-1 11 1716738617167386 Intron PKD1L1 MDA-1 7 47921683 47921683 Splice_Site PKD1L3MDA-1 16 71976911 71976911 RNA PKD2L2 MDA-1 5 137275656 137275656 3′UTRPMEL MDA-1 12 56351763 56351763 Missense_Mutation POU5F1 MDA-1 631130524 31130524 IGR PPM1D MDA-1 17 53677718 58677718 5′UTR PPP1R1BMDA-1 17 37783643 37783643 5′UTR PPP4R1 MDA-1 18 9583132 9583132Missense_Mutation PRKD3 MDA-1 2 37501808 37501808 Silent PRR24 MDA-1 1947778307 47778307 Missense_Mutation PSD4 MDA-1 2 113943416 113943416Intron RAB3GAP2 MDA-1 1 220320914 220320914 IGR RAC2 MDA-1 22 3763717437637174 Intron RAPGEF6 MDA-1 5 130788792 130788792 Missense_MutationRASGRF1 MDA-1 15 79254437 79254437 3′UTR RP11-54D18.3 MDA-1 9 1504790415047904 RNA RP11-794P6.2 MDA-1 11 111327280 111327280 Intron RTKN MDA-12 74657626 74657626 Missense_Mutation RTN3 MDA-1 11 63521144 63521144Silent SDCCAG8 MDA-1 1 243433414 243433414 Silent SH3BGR MDA-1 2140887097 40887097 3′UTR SLC13A3 MDA-1 20 45217841 45217841Missense_Mutation SLC17A4 MDA-1 6 25778222 25778222 Missense_MutationSLC25A15 MDA-1 13 41373522 41373522 Intron SLIRP MDA-1 14 7818960678189606 IGR SON MDA-1 21 34926768 34926768 Missense_Mutation SORCS2MDA-1 4 7194810 7194810 Missense_Mutation SPAG6 MDA-1 10 2268082922680829 Missense_Mutation SRRM2 MDA-1 16 2802811 2802811 5′UTR SUSD2MDA-1 22 24580150 24580150 Silent SYT14 MDA-1 1 210337320 210337320 IGRSZT2 MDA-1 1 43916570 43916570 3′UTR TDRD6 MDA-1 6 46657514 46657514Missense_Mutation TDRD6 MDA-1 6 46656177 46656177 Silent THBS1 MDA-1 1539885328 39885328 Silent TIE1 MDA-1 1 43779586 43779586Missense_Mutation TIE1 MDA-1 1 43770936 43770936 Missense_Mutation TLR4MDA-1 9 120476185 120476185 Nonsense_Mutation TMED4 MDA-1 7 4461902944619029 3′UTR TNFAIP8 MDA-1 5 118690924 118690924 5′UTR TNIK MDA-1 3170811733 170811733 Silent TRPC1 MDA-1 3 142443349 142443349 5′UTRTSPAN4 MDA-1 11 850346 850346 Silent UBA7 MDA-1 3 49851352 498513525′UTR USP37 MDA-1 2 219423357 219423357 Missense_Mutation USP4 MDA-1 349365185 49365185 Silent VPS4A MDA-1 16 69352811 69352811 IGR VWA8 MDA-113 42179335 42179335 Missense_Mutation WDR78 MDA-1 1 67390719 673907195′Flank WIPF1 MDA-1 2 175426977 175426977 3′UTR YPEL4 MDA-1 11 5741451057414510 Missense_Mutation ZCCHC4 MDA-1 4 25334843 25334843Missense_Mutation ZFHX4 MDA-1 8 77763768 77763768 Silent ZMYM6 MDA-1 135472669 35472669 Missense_Mutation ZNF215 MDA-1 11 6977338 6977338Missense_Mutation ZNF219 MDA-1 14 21567088 21567088 5′UTR ZNF28 MDA-1 1953303413 53303413 IGR ZNF408 MDA-1 11 46726678 46726678 Silent ZNF408MDA-1 11 46726773 46726773 Missense_Mutation ZNF408 MDA-1 11 4672677446726774 Silent ZNF517 MDA-1 8 146033535 146033535 Missense_MutationZNF560 MDA-1 19 9577708 9577708 Missense_Mutation ZNF696 MDA-1 8144378499 144378499 Silent ZNF883 MDA-1 9 115760450 115760450 lincRNAloss_17p MDA-1 17 11268 11268 arm_level DIS3 MDA-1 13 73346034 73346034Splice_Site FLG MDA-1 1 152285533 152285533 Missense_Mutation MTOR MDA-11 11273600 11273600 Silent DYSF MDA-1 2 71816674 71816674 IntronC1orf141 MDA-1 1 67591462 67591462 In_Frame_Del NFKBIA MDA-1 14 3587114435871144 3′UTR COL1A1 MDA-1 17 48268874 48268874 Intron SIPA1 MDA-1 1165417544 65417544 Intron DPAGT1 MDA-1 11 118972984 118972984 5′UTRPRPSAP1 MDA-1 17 74303641 74303641 IGR FN3K MDA-1 17 80707026 80707026Intron MGP MDA-1 12 15037257 15037257 Intron GUCY2D MDA-1 17 79064957906495 In_Frame_Del LMBR1 MDA-1 7 156549023 156549023 Intron COL6A1MDA-1 21 47407300 47407300 Intron TRPM4 MDA-1 19 49669256 49669256Intron RP11-295K3.1 MDA-1 11 1775188 1775188 Intron AE000661.50 MDA-1 1422887651 22887651 lincRNA C17orf66 MDA-1 17 34185385 34185385 IntronCLEC17A MDA-1 19 14706064 14706064 Intron EXOSC9 MDA-1 4 122731087122731087 Intron FARP2 MDA-1 2 242381871 242381871 Intron SON MDA-1 2134924280 34924280 In_Frame_Del NUDT17 MDA-1 1 145588656 145588656 IntronAKAP12 MDA-1 6 151672689 151672689 Missense_Mutation PLEKHG1 MDA-1 6151161157 151161157 Missense_Mutation SYNE1 MDA-1 6 152702311 152702311Missense_Mutation HORMAD2 MDA-1 22 30494844 30494844 Frame_Shift_DelATP8B2 MDA-1 1 154315677 154315677 Silent CTD-2090I13.1 MDA-1 1227618307 227618307 lincRNA LYST MDA-1 1 235901547 235901547 IntronEXOC6B MDA-1 2 72723734 72723734 Intron ADAMTS13 MDA-1 9 136303408136303408 Missense_Mutation ADRA1A MDA-1 8 26721824 26721824 SilentAGAP1 MDA-1 2 236708124 236708124 Silent ALOX15B MDA-1 17 79428587942858 Missense_Mutation ALOX15B MDA-1 17 7942611 7942611 Silent ASXL3MDA-1 18 31241641 31241641 Silent BAI3 MDA-1 6 70042825 70042825Missense_Mutation BMP2 MDA-1 20 6759416 6759416 Missense_MutationC1orf228 MDA-1 1 45163892 45163892 Missense_Mutation C6orf223 MDA-1 643968844 43968844 Missense_Mutation CDH23 MDA-1 10 73434870 73434870Splice_Site CHST9 MDA-1 18 24496858 24496858 Missense_Mutation CHSY3MDA-1 5 129520406 129520406 Missense_Mutation CLCN6 MDA-1 1 1190029811900298 3′UTR CLCN6 MDA-1 1 11900279 11900279 Nonstop_Mutation DMXL1MDA-1 5 118539121 118539121 Missense_Mutation EDC3 MDA-1 15 7496399774963997 Missense_Mutation FAM160B1 MDA-1 10 116623340 116623340 3′UTRGIMAP7 MDA-1 7 150217208 150217208 Missense_Mutation HERC2 MDA-1 1528525392 28525392 Missense_Mutation HIST1H2AC MDA-1 6 26124770 26124770Missense_Mutation HTR7 MDA-1 10 92508591 92508591 3′UTR IGSF9B MDA-1 11133792571 133792571 Missense_Mutation JUNB MDA-1 19 12902748 12902748Missense_Mutation KIRREL MDA-1 1 158047907 158047907 Missense_MutationMAGI2 MDA-1 7 78150857 78150857 5′UTR NLRP5 MDA-1 19 56565030 56565030Missense_Mutation OAS2 MDA-1 12 113447025 113447025 Missense_MutationPAX9 MDA-1 14 37132532 37132532 Silent PIWIL2 MDA-1 8 22168789 22168789Silent PSG9 MDA-1 19 43763145 43763145 Silent SEC11C MDA-1 18 5681677856816778 Missense_Mutation SEC14L3 MDA-1 22 30860845 30860845Missense_Mutation SLC18A3 MDA-1 10 50819048 50819048 Missense_MutationSLC26A9 MDA-1 1 205887995 205887995 Silent TMEM91 MDA-1 19 4186934841869348 Intron USP8 MDA-1 15 50782476 50782476 Missense_Mutation XRN1MDA-1 3 142119314 142119314 Missense_Mutation XRRA1 MDA-1 11 7455631574556315 Splice_Site ZNF318 MDA-1 6 43336757 43336757 Missense_MutationATM MDA-1 11 108203621 108203621 Nonsense_Mutation ATM MDA-1 11108206648 108206648 Missense_Mutation SERPINB13 MDA-1 18 6126439161264391 Missense_Mutation SF3B1 MDA-1 2 198266834 198266834Missense_Mutation TP53 MDA-1 17 7577539 7577539 Missense_Mutationgain_1q23.3 MDA-1 1 155899084 155899084 focal_level gain_TERT MDA-1 5 00 focal_level SFSWAP MDA-1 12 132262624 132262624 In_Frame_Insloss_10q25.1 MDA-1 10 0 0 focal_level gain_6p21.1 MDA-1 6 0 0focal_level gain_22q11.21 MDA-1 22 0 0 focal_level gain_MCL1 MDA-1 1 0 0focal_level gain_9p24.2 MDA-1 9 0 0 focal_level gain_11q13.2 MDA-1 11 00 focal_level AMOTL1 MDA-1 11 94532695 94532695 Silent CADPS2 MDA-1 7122056192 122056192 Missense_Mutation GAS2L3 MDA-1 12 101012342101012342 Missense_Mutation IDO1 MDA-1 8 39782839 39782839Missense_Mutation KBTBD11 MDA-1 8 1949784 1949784 Silent NPR2 MDA-1 935811698 35811698 IGR OR10K1 MDA-1 1 158435618 158435618Missense_Mutation PGBD1 MDA-1 6 28269532 28269532 Missense_MutationPLCH1 MDA-1 3 155199029 155199029 Missense_Mutation PSMD9 MDA-1 12122326731 122326731 5′UTR TAPT1 MDA-1 4 16228907 16228907 5′Flank TP53MDA-1 17 7578263 7578263 Nonsense_Mutation TSC2 MDA-1 16 2106716 2106716Silent SLC4A4 MDA-1 4 72102269 72102269 Intron BAZ2A MDA-1 12 5699518456995184 Frame_Shift_Ins gain_KRAS MDA-1 12 25243120 25243120focal_level loss_6q MDA-1 6 89926979 89926979 arm_level DRG2 MDA-1 1717991306 17991306 5′Flank homdel_2q37.3 MDA-1 2 242135224 242135224focal_level gain_AKT3 MDA-1 1 244999804 244999804 focal_levelAP000275.65 MDA-1 21 33975570 33975570 Frame_Shift_Ins ASCC3 MDA-1 6101248307 101248307 Silent CTNNA2 MDA-1 2 80136918 80136918Missense_Mutation DST MDA-1 6 56330919 56330919 Missense_MutationFAM179B MDA-1 14 45465138 45465138 Intron MTERFD2 MDA-1 2 242036571242036571 Intron PNLDC1 MDA-1 6 160222206 160222206 Missense_MutationRASSF8 MDA-1 12 26217538 26217538 Missense_Mutation RDH16 MDA-1 1257345813 57345813 Nonstop_Mutation SYNM MDA-1 15 99678194 99678194 IGRTCTN2 MDA-1 12 124172597 124172597 Splice_Site TRBV25-1 MDA-1 7142378971 142378971 RNA TRIM24 MDA-1 7 138210057 138210057Missense_Mutation gain_MDM4 MDA-1 1 0 0 focal_level gain_11q14.1 MDA-111 0 0 focal_level loss_9p13.1 MDA-1 9 0 0 focal_level gain_19q13.42MDA-1 19 0 0 focal_level gain_11q22.2 MDA-1 11 0 0 focal_levelgain_CCND1 MDA-1 11 0 0 focal_level gain_8q21.13 MDA-1 8 0 0 focal_levelMTMR3 MDA-1 22 30384504 30384504 5′UTR MYPN MDA-1 10 69961683 69961683Silent SPIDR MDA-1 8 48585972 48585972 Intron VNN1 MDA-1 6 133014444133014444 Missense_Mutation ERCC2 MDA-1 19 45860751 45860751Missense_Mutation homdel_19q13.32 MDA-1 19 45643447 45643447 focal_levelgain_NKX2-1 MDA-1 14 0 0 focal_level homdel_3p26.3 MDA-1 3 0 0focal_level homdel_11p15.5 MDA-1 11 372620 372620 focal_levelgain_5q35.3 MDA-1 5 0 0 focal_level loss_16q23.1 MDA-1 16 0 0focal_level gain_10p15.1 MDA-1 10 93514 93514 focal_level loss_1p36.23MDA-1 1 0 0 focal_level homdel_STK11 MDA-1 19 66207 66207 focal_levelgain_ZNF217 MDA-1 20 0 0 focal_level homdel_BRCA1 MDA-1 17 0 0focal_level gain_3q29 MDA-1 3 184035626 184035626 focal_level FAM13CMDA-1 10 61120839 61120839 Intron IGHV1-24 MDA-1 14 106733177 106733177RNA NDUFA9 MDA-1 12 4768297 4768297 Missense_Mutation PABPC4L MDA-1 4135121930 135121930 Missense_Mutation TDRD9 MDA-1 14 104493257 104493257Missense_Mutation homdel_16p13.3 MDA-1 16 64355 64355 focal_levelhomdel_17q25.3 MDA-1 17 78933941 78933941 focal_level loss_9q34.3 MDA-19 134738488 134738488 focal_level gain_E2F3 MDA-1 6 17600996 17600996focal_level loss_19q MDA-1 19 26500001 26500001 arm_level loss_19p MDA-119 7794161 7794161 arm_level loss_15q MDA-1 15 20169963 20169963arm_level homdel_12q24.33 MDA-1 12 124158259 124158259 focal_levelgain_17q11.2 MDA-1 17 22023424 22023424 focal_level gain_13q34 MDA-1 13111009859 111009859 focal_level gain_13q MDA-1 13 28636105 28636105arm_level loss_18p MDA-1 18 3135636 3135636 arm_level loss_1q44 MDA-1 1244999804 244999804 focal_level homdel_4p16.3 MDA-1 4 502688 502688focal_level loss_APC MDA-1 5 98192256 98192256 focal_level gain_ERBB2MDA-1 17 36352492 36352492 focal_level gain_9p MDA-1 9 14783 14783arm_level homdel_10q26.3 MDA-1 10 129839197 129839197 focal_levelgain_NEDD9 MDA-1 6 203616 203616 focal_level homdel_21q22.3 MDA-1 2141032953 41032953 focal_level homdel_16q23.1 MDA-1 16 74908224 74908224focal_level homdel_IKZF2 MDA-1 2 211421050 211421050 focal_levelhomdel_1p36.23 MDA-1 1 1391715 1391715 focal_level loss_22q MDA-1 2219026506 19026506 arm_level AMOTL2 MDA-2 3 134090204 134090204 SilentANAPC4 MDA-2 4 25382101 25382101 Splice_Site ANKRD11 MDA-2 16 8934151889341518 Nonsense_Mutation BIRC3 MDA-2 11 102207790 102207790Missense_Mutation C8orf48 MDA-2 8 13424852 13424852 Nonsense_MutationCDH11 MDA-2 16 65026835 65026835 Missense_Mutation COL6A5 MDA-2 3130188150 130188150 Silent CORO1A MDA-2 16 30198004 30198004Missense_Mutation CPEB2 MDA-2 4 15005914 15005914 Silent DIRAS3 MDA-2 168512864 68512864 Silent DNAH9 MDA-2 17 11648208 11648208Missense_Mutation EGR2 MDA-2 10 64573332 64573332 Missense_Mutation ELP3MBA-2 8 28019514 28019514 Splice_Site ENKD1 MDA-2 16 67696094 67696094IGR ENO2 MDA-2 12 7026829 7026829 Intron FLNB MDA-2 3 57994391 57994391Missense_Mutation FPR2 MDA-2 19 52272264 52272264 Missense_MutationGABARAPL2 MDA-2 16 75601950 75601950 Missense_Mutation GPR133 MDA-2 12131488811 131488811 Nonsense_Mutation HCN1 MDA-2 5 45396641 45396641Missense_Mutation IGHMBP2 MDA-2 11 68697880 68697880 Intron IKBIP MDA-212 99020023 99020023 Silent INTU MDA-2 4 128608937 128608937Missense_Mutation IRS2 MDA-2 13 110436229 110436229 Silent KIAA0196MDA-2 8 126073352 126073352 Missense_Mutation MED7 MDA-2 5 156566010156566010 Missense_Mutation MICAL3 MDA-2 22 18387572 18387572Missense_Mutation MTMR12 MDA-2 5 32263277 32263277 Missense_MutationOBSL1 MDA-2 2 220417648 220417648 Silent PCGF5 MDA-2 10 9300030393000303 Missense_Mutation SCO1 MDA-2 17 10584508 10584508 SilentSLC12A4 MDA-2 16 67980168 67980168 Missense_Mutation SLC26A8 MDA-2 635987370 35987370 Missense_Mutation SNED1 MDA-2 2 241988534 241988534Missense_Mutation SOX5 MDA-2 12 23793755 23793755 Silent SYNE1 MDA-2 6152776560 152776560 Splice_Site TACR2 MDA-2 10 71164666 71164666 SilentTBX6 MDA-2 16 30100374 30100374 Missense_Mutation TDRD6 MDA-2 6 4665609746656097 Missense_Mutation TMEM175 MDA-2 4 947036 947036Missense_Mutation UBA52 MDA-2 19 18686046 18686046 3′UTR ZNF408 MDA-2 1146722598 46722598 Start_Codon_SNP ATM MDA-2 11 108199835 108199835Missense_Mutation IRF4 MDA-2 6 394950 394950 Missense_Mutation IRF4MDA-2 6 394951 394951 Missense_Mutation TP53 MDA-2 17 7578406 7578406Missense_Mutation gain_21q MDA-2 21 0 0 arm_level homdel_17q25.3 MDA-217 76692090 76692090 focal_level homdel_22q13.32 MDA-2 22 4254037442540374 focal_level homdel_19q13.32 MDA-2 19 40400564 40400564focal_level homdel_14q32.33 MDA-2 14 102323122 102323122 focal_levelloss_18q23 MDA-2 18 74962837 74962837 focal_level homdel_17p13.3 MDA-217 11268 11268 focal_level gain_1q23.3 MDA-2 1 153631640 153631640focal_level NLGN1 MDA-2 3 173993271 173993271 Frame_Shift_Delgain_22q11.21 MDA-2 22 19466599 19466599 focal_level gain_MDM4 MDA-2 1204234120 204234120 focal_level homdel_10q25.1 MDA-2 10 0 0 focal_levelhomdel_STK11 MDA-2 19 1108895 1108895 focal_level loss_12q24.33 MDA-2 120 0 focal_level homdel_19q13.43 MDA-2 19 54819095 54819095 focal_levelhomdel_2q37.3 MDA-2 2 0 0 focal_level gain_ZNF217 MDA-2 20 0 0focal_level gain_E2F3 MDA-2 6 203616 203616 focal_level loss_19p MDA-219 66207 66207 arm_level homdel_7p22.3 MDA-2 7 193501 193501 focal_levelgain_4p MDA-2 4 6578378 6578378 arm_level gain_12q MDA-2 12 3580000135800001 arm_level gain_MDM2 MDA-2 12 57957163 57957163 focal_levelgain_NEDD9 MDA-2 6 203616 203616 focal_level loss_5q35.3 MDA-2 5179538518 179538518 focal_level loss_20p MDA-2 20 68379 68379 arm_levelgain_8p MDA-2 8 0 0 arm_level gain_CCND1 MDA-2 11 0 0 focal_levelhomdel_21q22.3 MDA-2 21 46078042 46078042 focal_level homdel_16q23.1MDA-2 16 0 0 focal_level gain_18q MDA-2 18 0 0 arm_level loss_16p MDA-216 15680630 15680630 arm_level loss_11q23.1 MDA-2 11 82444131 82444131focal_level NELL1 MDA-2 11 20699494 20699494 Frame_Shift_Del loss_22qMDA-2 22 16157621 16157621 arm_level gain_17q24.2 MDA-2 17 0 0focal_level gain_IGF1R MDA-2 15 90347519 90347519 focal_level loss_MLL3MDA-2 7 0 0 focal_level homdel_1p36.23 MDA-2 1 12175 12175 focal_levelgain_NKX2-1 MDA-2 14 0 0 focal_level gain_13q MDA-2 13 0 0 arm_levelloss_15q15.1 MDA-2 15 0 0 focal_level gain_CDK4 MDA-2 12 5795716357957163 focal_level loss_8p21.2 MDA-2 8 0 0 focal_level gain_10p15.1MDA-2 10 0 0 focal_level gain_11q14.1 MDA-2 11 0 0 focal_levelgain_7q36.3 MDA-2 7 154720339 154720339 focal_level gain_12p MDA-2 1219592927 19592927 arm_level homdel_10q26.3 MDA-2 10 134062573 134062573focal_level gain_12p13.33 MDA-2 12 78865 78865 focal_level gain_9p24.2MDA-2 9 0 0 focal_level homdel_9q34.3 MDA-2 9 136081283 136081283focal_level homdel_4p16.3 MDA-2 4 59385 59385 focal_level gain_KRASMDA-2 12 19592927 19592927 focal_level homdel_5q35.3 MDA-2 5 0 0focal_level gain_3q MDA-2 3 130313169 130313169 arm_level loss_17p MDA-217 11268 11268 arm_level loss_4p MDA-2 4 6578378 6578378 arm_levelgain_5q MDA-2 5 69736634 69736634 arm_level gain_11q13.2 MDA-2 11 0 0focal_level homdel_15q15.1 MDA-2 15 20169963 20169963 focal_level AGXT2MDA-3 5 35037047 35037047 Splice_Site BCL11B MDA-3 14 99640472 996404723′UTR BTBD19 MDA-3 1 45279566 45279566 3′UTR CAPRIN2 MDA-3 12 3088175530881755 Nonsense_Mutation CDH2 MDA-3 18 25565083 25565083Missense_Mutation CEP112 MDA-3 17 64125931 64125931 Missense_MutationCPN1 MDA-3 10 101823394 101823394 Missense_Mutation DDX49 MDA-3 1919038937 19038937 Splice_Site DNAH17 MDA-3 17 76456002 76456002Missense_Mutation DTNA MDA-3 18 32392010 32392010 Missense_MutationHNF1B MDA-3 17 36099531 36099531 Silent HNF4A MDA-3 20 43053034 43053034Intron HTRA3 MDA-3 4 8288312 8288312 Silent IL1R2 MDA-3 2 102641126102641126 Missense_Mutation ITGA4 MDA-3 2 182402403 182402403 IGR LAPTM5MDA-3 1 31230602 31230602 De_novo_Start_OutOfFrame MAN1B1 MDA-3 9140002966 140002966 Missense_Mutation NBPF22P MDA-3 5 85578423 85578423RNA NCKAP1 MDA-3 2 183800091 183800091 Missense_Mutation NIPAL4 MDA-3 5156894089 156894089 Missense_Mutation NRXN2 MDA-3 11 64435958 64435958Missense_Mutation OBSCN MDA-3 1 228399849 228399849 Missense_MutationOR4C6 MDA-3 11 55433623 55433623 3′UTR OR4C6 MDA-3 11 55433624 554336243′UTR OR4N5 MDA-3 14 20612441 20612441 Nonsense_Mutation OR52N2 MDA-3 115842456 5842456 Silent P4HA3 MDA-3 11 74022497 74022497Missense_Mutation PCSK2 MDA-3 20 17462397 17462397 Silent PDCD11 MDA-310 105184926 105184926 Silent PDE6C MDA-3 10 95372819 95372819Missense_Mutation PDE6H MDA-3 12 15131080 15131080 Splice_Site PNOCMDA-3 8 28186755 28186755 Silent POU5F1 MDA-3 6 31138427 31138427 IntronPRKAA2 MDA-3 1 57169881 57169881 Silent RBL2 MDA-3 16 53503957 53503957Missense_Mutation RPS7 MDA-3 2 3625354 3625354 Missense_Mutation SH3TC2MDA-3 5 148384418 148384418 Silent SLCO3A1 MDA-3 15 92663804 92663804Silent SNAP25 MDA-3 20 10277587 10277587 Missense_Mutation SPATA17 MDA-31 217915399 217915399 Missense_Mutation SYNPO2 MDA-3 4 119978776119978776 Missense_Mutation SYT3 MDA-3 19 51140536 51140536Missense_Mutation TMEM222 MDA-3 1 27662013 27662013 3′UTR TRIP10 MDA-319 6741049 6741049 Missense_Mutation VPS13B MDA-3 8 100147957 100147957Missense_Mutation VWDE MDA-3 7 12409877 12409877 Silent WDFY3 MDA-3 485729561 85729561 Missense_Mutation ZCCHC10 MDA-3 5 132362200 132362200Silent loss_11q23.1 MDA-3 11 103780484 103780484 focal_level SF3B1 MDA-32 198267361 198267361 Missense_Mutation gain_MCL1 MDA-3 1 0 0focal_level CYB5RL MDA-3 1 54640457 54640457 Frame_Shift_Del gain_8qMDA-3 8 54142123 54142123 arm_level homdel_STK11 MDA-3 19 0 0focal_level TP53 MDA-3 17 7578480 7578480 In_Frame_Del homdel_APC MDA-35 0 0 focal_level gain_IGF1R MDA-3 15 0 0 focal_level loss_14q32.33MDA-3 14 106330010 106330010 focal_level loss_8p MDA-3 8 417733 417733arm_level homdel_14q32.33 MDA-3 14 0 0 focal_level gain_11q22.2 MDA-3 110 0 focal_level homdel_RB1 MDA-3 13 0 0 focal_level loss_19q MDA-3 19 00 arm_level loss_19p MDA-3 19 0 0 arm_level loss_6p MDA-3 6 0 0arm_level loss_3p26.3 MDA-3 3 0 0 focal_level loss_17p MDA-3 17 1126811268 arm_level homdel_15q15.1 MDA-3 15 35045126 35045126 focal_levelEIF4A1 MDA-3 17 7474085 7474085 5′Flank Unknown DFCI-5243 13 114453897114453897 IGR AC015849.16 DFCI-5243 17 34235657 34235657 lincRNAAC015849.16 DFCI-5243 17 34235658 34235658 lincRNA AHNAK DFCI-5243 1162298814 62298814 Silent ANPEP DFCI-5243 15 90346930 90346930Missense_Mutation ATP4A DFCI-5243 19 36051399 36051399 Missense_MutationB3GALT2 DFCI-5243 1 193150535 193150535 Missense_Mutation BHLHE40DFCI-5243 3 5021888 5021888 Intron BUB1 DFCI-5243 2 111413397 111413397Missense_Mutation C17orf70 DFCI-5243 17 79517349 79517349Missense_Mutation C1orf101 DFCI-5243 1 244715837 244715837 SilentC1orf141 DFCI-5243 1 67561036 67561036 Missense_Mutation C8orf37DFCI-5243 8 96264494 96264494 Missense_Mutation CEP152 DFCI-5243 1549085631 49085631 Missense_Mutation CHD2 DFCI-5243 15 93557977 93557977Nonsense_Mutation CHRNB2 DFCI-5243 1 154542795 154542795Missense_Mutation COL12A1 DFCI-5243 6 75818846 75818846Missense_Mutation CPZ DFCI-5243 4 8620213 8620213 Missense_MutationCRIM1 DFCI-5243 2 36739471 36739471 Missense_Mutation CRIP2 DFCI-5243 14105944697 105944697 Splice_Site DKK3 DFCI-5243 11 11989955 11989955Missense_Mutation DNAH8 DFCI-5243 6 38819441 38819441 Silent DOCK1DFCI-5243 10 129249683 129249683 Missense_Mutation FAR2 DFCI-5243 1229446197 29446197 Intron FLNB DFCI-5243 3 58132626 58132626 Silent FTMTDFCI-5243 5 121187843 121187843 Missense_Mutation GAL3ST2 DFCI-5243 2242742809 242742809 Missense_Mutation GIT1 DFCI-5243 17 2790268227902682 Missense_Mutation GUCA2A DFCI-5243 1 42628585 42628585Missense_Mutation IGHG1 DFCI-5243 14 106208271 106208271 RNA IGHJ6DFCI-5243 14 106330112 106330112 RNA IGHJ6 DFCI-5243 14 106330303106330303 RNA IGHM DFCI-5243 14 106322169 106322169 RNA IGHV2-26DFCI-5243 14 106757764 106757764 RNA IGHV3-23 DFCI-5243 14 106725322106725322 RNA IGHV3-23 DFCI-5243 14 106725401 106725401 RNA IGHV3-23DFCI-5243 14 106725638 106725638 RNA IGLV3-21 DFCI-5243 22 2305543923055439 RNA IGLV3-21 DFCI-5243 22 23055509 23055509 RNA IGLV3-21DFCI-5243 22 23055535 23055535 RNA IGLV4-3 DFCI-5243 22 2321393923213939 RNA IGLV4-3 DFCI-5243 22 23213951 23213951 RNA IGLV4-3DFCI-5243 22 23214029 23214029 RNA IGLV4-3 DFCI-5243 22 2321403223214032 RNA IGLV4-3 DFCI-5243 22 23214070 23214070 RNA LAMB4 DECI-52437 107748104 107748104 Missense_Mutation LPPR4 DFCI-5243 1 9977147899771478 Missense_Mutation LRP1 DFCI-5243 12 57593084 57593084Nonsense_Mutation MEFV DFCI-5243 16 3304458 3304458 Intron MLH3DFCI-5243 14 75515428 75515428 Nonsense_Mutation MMP16 DFCI-5243 889053931 89053931 Missense_Mutation MYH7 DFCI-5243 14 23884924 23884924Missense_Mutation NAALADL2 DFCI-5243 3 174814707 174814707 Silent NLRC5DFCI-5243 16 57060669 57060669 Missense_Mutation NPAT DFCI-5243 11108031824 108031824 Missense_Mutation NRXN3 DFCI-5243 14 8032817080328170 Missense_Mutation NUAK1 DFCI-5243 12 106477645 106477645 SilentOR4K14 DFCI-5243 14 20482830 20482830 Missense_Mutation PAQR4 DFCI-524316 3021331 3021331 Intron PCLO DFCI-5243 7 82582228 82582228Missense_Mutation PLA2G2E DFCI-5243 1 20246902 20246902Missense_Mutation PLCB1 DFCI-5243 20 8665676 8665676 Missense_MutationPPA1 DFCI-5243 10 71977629 71977629 Missense_Mutation RAPGEF2 DFCI-52434 160279443 160279443 3′UTR RCC2 DFCI-5243 1 17752073 17752073Missense_Mutation REEP6 DFCI-5243 19 1497371 1497371 3′UTR RGMADFCI-5243 15 93595250 93595250 Silent RING1 DFCI-5243 6 3317773633177736 Missense_Mutation RNF213 DFCI-5243 17 78313787 78313787Missense_Mutation SALL1 DFCI-5243 16 51174769 51174769 5′Flank SCNN1ADFCI-5243 12 6464558 6464558 Silent SLC35E2B DFCI-5243 1 1602985 1602985Missense_Mutation SNAP91 DFCI-5243 6 84300969 84300969 Missense_MutationSNAP91 DFCI-5243 6 84417596 84417596 Silent SNCAIP DFCI-5243 5 121776408121776408 Missense_Mutation SPDYE4 DFCI-5243 17 8660637 8660637Nonsense_Mutation SYMPK DFCI-5243 19 46351042 46351042 Missense_MutationTENM3 DFCI-5243 4 183674641 183674641 Missense_Mutation TIMD4 DFCI-52435 156381444 156381444 Missense_Mutation TMEM178A DFCI-5243 2 3993127139931271 Missense_Mutation TMEM216 DFCI-5243 11 61160711 61160711Missense_Mutation TMEM242 DFCI-5243 6 157744517 157744517 Silent TMPRSS9DFCI-5243 19 2399142 2399142 Silent TRIM27 DFCI-5243 6 28879492 28879492Missense_Mutation TRIML2 DFCI-5243 4 189019400 189019400Nonsense_Mutation UGT3A1 DFCI-5243 5 35965535 35965535 Missense_MutationWDR46 DFCI-5243 6 33256726 33256726 Missense_Mutation ZFP36L2 DFCI-52432 43452046 43452046 Silent ZNF488 DFCI-5243 10 48370750 48370750Missense_Mutation SF3B1 DFCI-5243 2 198267364 198267364Missense_Mutation SF3B1 DFCI-5243 2 198267360 198267360Missense_Mutation SF3B1 DFCI-5243 2 198267355 198267355Missense_Mutation TP53 DFCI-5243 17 7577568 7577568 Missense_Mutationgain_8q24.3 DFCI-5243 8 0 0 focal_level ADNP2 DFCI-5243 18 7789657677896576 Frame_Shift_Del loss_9p21.2 DFCI-5243 9 0 0 focal_levelloss_9p21.3 DFCI-5243 9 0 0 focal_level SEC16A DFCI-5243 9 139354108139354108 Intron homdel_14q32.33 DFCI-5243 14 106436541 106436541focal_level loss_18p DFCI-5243 18 0 0 arm_level gain_MYC DFCI-5243 8 0 0focal_level loss_9q34.3 DFCI-5243 9 0 0 focal_level gain_1q23.3DFCI-5243 1 0 0 focal_level gain_22q11.21 DFCI-5243 22 0 0 focal_levelloss_5p DFCI-5243 5 0 0 arm_level loss_14q DFCI-5243 14 0 0 arm_levelloss_5q DFCI-5243 5 0 0 arm_level C5orf45 DFCI-5243 5 179278379179278379 Intron DNAH6 DFCI-5243 2 84851685 84851685 Frame_Shift_Delloss_8p11.21 DFCI-5243 8 0 0 focal_level gain_4q DFCI-5243 4 0 0arm_level gain_4p DFCI-5243 4 0 0 arm_level loss_18q23 DFCI-5243 18 0 0focal_level loss_9p24.1 DFCI-5243 9 0 0 focal_level ZFC3H1 DFCI-5243 1272004352 72004352 Intron loss_PARK2 DFCI-5243 6 0 0 focal_levelgain_MCL1 DFCI-5243 1 0 0 focal_level LIFR DFCI-5243 5 38506742 38506742Intron loss_4q DFCI-5243 4 0 0 arm_level gain_8q DFCI-5243 8 9181393091813930 arm_level gain_8p DFCI-5243 8 0 0 arm_level loss_4p DFCI-5243 40 0 arm_level gain_10q DFCI-5243 10 0 0 arm_level gain_18p DFCI-5243 180 0 arm_level PDE6A DFCI-5243 5 149247333 149247333 Frame_Shift_DelC10orf137 DFCI-5243 10 127422796 127422796 Intron gain_8q23.3 DECI-52438 0 0 focal_level loss_RB1 DFCI-5243 13 0 0 focal_level loss_10qDFCI-5243 10 0 0 arm_level gain_8q22.2 DFCI-5243 8 0 0 focal_levelloss_8p DFCI-5243 8 0 0 arm_level RAB4B-EGLN2 DFCI-5243 19 4128651341286513 Intron gain_13q DFCI-5243 13 0 0 arm_level CHD2 DFCI-5243 1593489277 93489277 Frame_Shift_Del DDX11 DFCI-5243 12 31255035 31255035Intron gain_7q36.3 DFCI-5243 7 0 0 focal_level MYB DFCI-5243 6 135507082135507082 Frame_Shift_Del homdel_RB1 DFCI-5243 13 46946342 46946342focal_level gain_6q DFCI-5243 6 0 0 arm_level SRSF12 DFCI-5243 689816808 89816808 Intron gain_7q DFCI-5243 7 0 0 arm_level gain_7pDFCI-5243 7 0 0 arm_level loss_6p DFCI-5243 6 0 0 arm_level loss_17p13.3DFCI-5243 17 11268 11268 focal_level loss_17p DFCI-5243 17 0 0 arm_levelloss_10p15.3 DFCI-5243 10 0 0 focal_level gain_6p DFCI-5243 6 0 0arm_level gain_5q DFCI-5243 5 0 0 arm_level loss_21q DFCI-5243 21 0 0arm_level MTR DFCI-5243 1 237013559 237013559 Intron ANGPTL6 DFCI-559119 10204247 10204247 Missense_Mutation BCAR1 DFCI-5591 16 7527119875271198 Silent BHLHA15 DFCI-5591 7 97841917 97841917 Missense_MutationBID DFCI-5591 22 18218233 18218233 3′UTR C10orf11 DFCI-5591 10 7781842777818427 Nonsense_Mutation C7 DFCI-5591 5 40972658 40972658Nonsense_Mutation CEND1 DFCI-5591 11 788346 788346 Missense_MutationCXCR2 DFCI-5591 2 219000146 219000146 Missense_Mutation DEFB114DFCI-5591 6 49928146 49928146 Silent DNAH5 DFCI-5591 5 13810295 13810295Silent DNHD1 DFCI-5591 11 6561128 6561128 Missense_Mutation EDNRADFCI-5591 4 148406926 148406926 Silent EXOC6B DFCI-5591 2 7272707872727078 Silent GRM5 DFCI-5591 11 88323800 88323800 Silent HADHDFCI-5591 4 108926012 108926012 Intron IRF8 DFCI-5591 16 8595226885952268 Missense_Mutation KIF20B DFCI-5591 10 91528048 91528048Splice_Site LPHN3 DFCI-5591 4 62936529 62936529 Missense_Mutation MPP5DFCI-5591 14 67768145 67768145 Nonsense_Mutation MT1A DFCI-5591 1656669949 56669949 5′Flank MTIF3 DFCI-5591 13 28009715 28009715 IGR NAV2DFCI-5591 11 20044578 20044578 Intron NCKAP5 DFCI-5591 2 133543162133543162 Silent NDRG1 DFCI-5591 8 134260968 134260968 Missense_MutationPDZRN4 DFCI-5591 12 41966165 41966165 Splice_Site RBM38 DFCI-5591 2055967758 55967758 Missense_Mutation RD3 DFCI-5591 1 211654657 211654657Missense_Mutation RIOK1 DFCI-5591 6 7403005 7403005 Intron ROBO4DFCI-5591 11 124756289 124756289 Intron SAMHD1 DFCI-5591 20 3554545335545453 Splice_Site SAMHD1 DFCI-5591 20 35545450 35545450Nonsense_Mutation SEMA4G DFCI-5591 10 102738735 102738735Missense_Mutation SEMA6D DFCI-5591 15 48062908 48062908 Silent SLC25A10DFCI-5591 17 79682553 79682553 Missense_Mutation SPATS2 DFCI-5591 1249893882 49893882 Missense_Mutation TENM2 DFCI-5591 5 167379775167379775 Missense_Mutation TMEM176B DFCI-5591 7 150487604 150487604 IGRTMPRSS15 DFCI-5591 21 19666585 19666585 Splice_Site TNIP3 DFCI-5591 4122085425 122085425 Intron TRAF5 DFCI-5591 1 211526705 211526705Missense_Mutation TRBC2 DFCI-5591 7 142498969 142498969 RNA ZNF16DFCI-5591 8 146157523 146157523 Missense_Mutation ZNF292 DFCI-5591 687964825 87964825 Missense_Mutation ZNF296 DFCI-5591 19 4557537045575370 Missense_Mutation ZNF629 DFCI-5591 16 30793826 30793826Missense_Mutation FAT1 DFCI-5591 4 187628840 187628840 Silent KELDFCI-5591 7 142658532 142658532 Silent NRAS DFCI-5591 1 115256529115256529 Missense_Mutation loss_14q32.33 DFCI-5591 14 106478155106478155 focal_level SAMHD1 DFCI-5591 20 35545235 35545235 Splice_SiteIRF8 DFCI-5591 16 85954853 85954853 Frame_Shift_Del homdel_APC DFCI-55915 89854675 89854675 focal_level homdel_14q32.33 DFCI-5591 14 0 0focal_level HAL DFCI-5591 12 96379985 96379985 Intron NOTCH1 DFCI-5591 9139390649 139390649 Frame_Shift_Del XPO4 DFCI-5591 13 21370223 21370223Frame_Shift_Del SAMHD1 DFCI-5591 20 35526886 35526886 Frame_Shift_InsRAI1 DFCI-5591 17 17699398 17699398 Frame_Shift_Ins ABCA13 JB-0126 748314267 48314267 Silent ANO5 JB-0126 11 22283745 22283745Missense_Mutation ASXL3 JB-0126 18 31318986 31318986 Missense_MutationATP12A JB-0126 13 25283966 25283966 Splice_Site BRSK2 JB-0126 11 14665751466575 Missense_Mutation C17orf62 JB-0126 17 80401837 80401837 IntronCDK5R1 JB-0126 17 30815159 30815159 Missense_Mutation COL12A1 JB-0126 675851747 75851747 Splice_Site COX15 JB-0126 10 101476107 101476107Nonsense_Mutation CTD-3064M3.7 JB-0126 8 142446906 142446906 RNA DROSHAJB-0126 5 31422948 31422948 Missense_Mutation DSEL JB-0126 18 6518036165180361 Missense_Mutation FAM120A JB-0126 9 96318716 96318716Missense_Mutation FSIP2 JB-0126 2 186673166 186673166 Nonsense_MutationGALNT5 JB-0126 2 158156101 158156101 IGR GPT JB-0126 8 145731356145731356 Intron GRIK3 JB-0126 1 37267592 37267592 Missense_MutationIRAK1BP1 JB-0126 6 79607875 79607875 Missense_Mutation MIR518C JB-012619 54209520 54209520 RNA MYH9 JB-0126 22 36689375 36689375 Splice_SiteNXF1 JB-0126 11 62571282 62571282 Missense_Mutation OR5AR1 JB-0126 1156431642 56431642 Missense_Mutation OR5J2 JB-0126 11 55944294 55944294Silent PDIA3 JB-0126 15 44062481 44062481 Missense_Mutation PGLYRP3JB-0126 1 153283186 153283186 5′UTR RCC1 JB-0126 1 28835165 28835165Intron RP11-343C2.12 JB-0126 16 69362870 69362870 3′UTR RPL22L1 JB-01263 170585988 170585988 Intron SLC12A5 JB-0126 20 44675042 44675042Missense_Mutation SNHG14 JB-0126 15 25328564 25328564 RNA TENM3 JB-01264 183600992 183600992 Missense_Mutation TOM1L2 JB-0126 17 1778797817787978 Silent TP53 JB-0126 17 7577498 7577498 Splice_Site TP53 JB-012617 7577610 7577610 Splice_Site TRIM37 JB-0126 17 57125047 57125047Missense_Mutation TRIP4 JB-0126 15 64698567 64698567 Missense_MutationTUBGCP2 JB-0126 10 135111566 135111566 Missense_Mutation ZNF12 JB-0126 76746108 6746108 5′UTR ZNF254 JB-0126 19 24216365 24216365 5′UTR ZNF560JB-0126 19 9577562 9577562 Silent loss_14q32.33 JB-0126 14 106757700106757700 focal_level PTPN11 JB-0126 12 112888166 112888166Missense_Mutation SF3B1 JB-0126 2 198266611 198266611 Splice_Site SF3B1JB-0126 2 198267360 198267360 Missense_Mutation TP53 JB-0126 17 75783957578395 Missense_Mutation TP53 JB-0126 17 7578538 7578538Missense_Mutation TP53 JB-0126 17 7577563 7577563 Missense_Mutationhomdel_RB1 JB-0126 13 0 0 focal_level TC2N JB-0126 14 92251797 92251797Intron gain_22q11.21 JB-0126 22 0 0 focal_level loss_11p15.5 JB-0126 11619532 619532 focal_level SYNE1 JB-0126 6 152763448 152763448 Intronhomdel_APC JB-0126 5 0 0 focal_level BAZ2A JB-0126 12 56994757 56994757Frame_Shift_Del Hugo_Symbol Variant_Type Reference_AlleleTumor_Seq_Allele1 Tumor_Seq_Allele2 Unknown SNP C C T AATK SNP G G AABCD4 SNP G G C ABCF1 SNP G G A ABTB2 SNP C C T ACAD10 SNP G G T ACAT1SNP T T C ACD SNP T T G ACIN1 SNP T T C ACKR3 SNP C C T ADC SNP C C GADORA3 SNP C C T AHNAK2 SNP G G A ALG8 SNP G G A ANO9 SNP A A G ARMC12SNP C C T ARSK SNP G G A ASAP2 SNP G G A ATP13A1 SNP G G A ATP6V0B SNP GG A ATP6V0B SNP G G A ATP8B4 SNP T T c BFSP1 SNP G G T C15orf27 SNP C CG C15orf39 SNP G G A C16orf45 SNP A A C C19orf18 SNP G G A C21orf58 SNPC C T C2CD2 SNP C C T CACNA1S SNP C C G CAD SNP G G A CADM3 SNP C C TCAPRIN2 SNP G G A CASP5 SNP T T G CCDC57 SNP G G A CDC42BPB SNP C C TCDK6 SNP G G T CENPT SNP C C T CEPT1 SNP T T G CES4A SNP G G A CFTR SNPA A T CHRNA4 SNP C C A CHRNA4 SNP C C A CHRNB3 SNP A A G CHTF18 SNP A AG CLTB SNP G G A COL18A1 SNP C C G COMMD4 SNP C C G CSMD2 SNP C C TCTBP1 SNP C C T CYP1A2 SNP G G T DEFA4 SNP A A T DEFB1 SNP T T C DIABLOSNP A A T DOPEY2 SNP C C G DST SNP T T C DYNC1H1 SNP A A G DYSF SNP C CG EIF2AK4 SNP T T C ENPEP SNP G G A EP300 SNP T T C EPHB4 SNP C C TERCC6 SNP G G A ESYT1 SNP G G A EXPH5 SNP C C G EXPH5 SNP G G T FAM111BSNP C C T FAM65B SNP C C G FAM71B SNP T T G FBXL16 SNP G G A FLNB SNP GG A FLYWCH2 SNP G G A FNBP4 SNP C C T FNBP4 SNP G G C FZD8 SNP C C GGCC1 SNP G G A GNA15 SNP C C T GPR144 SNP C C T GRIP1 SNP C C T HAVCR1SNP G G A HGD SNP C C T HNRNPM SNP C C T HNRNPUL2 SNP T T C HSD17B12 SNPG G A HSDL2 SNP T T C IGHM SNP C C A INTS6 SNP A A G IQGAP1 SNP A A GITPR1 SNP G G A JMJD1C SNP G G A JMJD1C SNP G G T JPH3 SNP G G A JPH4SNP G G A KDELR2 SNP G G A KIAA0020 SNP T T C KIAA1109 SNP A A G KLF11SNP A A G KNTC1 SNP C C A KRT35 SNP C C A KRTAP24-1 SNP T T A LINC00207SNP T T C LRIG2 SNP A A G LRRC16B SNP C C A LSM14B SNP G G A MB21D2 SNPT T C MCF2L2 SNP C C A MED12L SNP G G A MIR1207 SNP A A G MLXIP SNP T TC MSLNL SNP G G A MST1 SNP A A G MT1L SNP T T C MT3 SNP G G A MTHFD2LSNP A A G MUC17 SNP G G A MYO10 SNP G G C NARS SNP T T G NCBP1 SNP G G TNCOR2 SNP C C T NDUFB10 SNP T T C NEK9 SNP A A G NEU4 SNP C C A NFATC4SNP G G A NKX2-6 SNP A A G NNT SNP C C T NPAT SNP G G C NRXN1 SNP G G ANUMBL SNP G G T OGFOD2 SNP C C T ORAI3 SNP G G A OTUD7B SNP A A G OXSR1SNP C C A PAFAH1B3 SNP C C G PALD1 SNP A A G PAPPA SNP T T C PCDHGB3 SNPG G A PCID2 SNP T T C PDE6A SNP G G A PI4KA SNP G G A PIK3C2A SNP C C TPKD1L1 SNP G G T PKD1L3 SNP A A G PKD2L2 SNP C C A PMEL SNP C C T POU5F1SNP C C A PPM1D SNP C C G PPP1R1B SNP G G C PPP4R1 SNP T T C PRKD3 SNP AA C PRR24 SNP C C T PSD4 SNP C C T RAB3GAP2 SNP G G A RAC2 SNP G G ARAPGEF6 SNP C C T RASGRF1 SNP C C A RP11-54D18.3 SNP T T C RP11-794P6.2SNP C C A RTKN SNP C C T RTN3 SNP C C A SDCCAG8 SNP C C T SH3BGR SNP C CA SLC13A3 SNP C C T SLC17A4 SNP C C T SLC25A15 SNP C C T SLIRP SNP G G ASON SNP G G A SORCS2 SNP C C G SPAG6 SNP T T C SRRM2 SNP A A T SUSD2 SNPC C T SYT14 SNP T T C SZT2 SNP G G A TDRD6 SNP A A G TDRD6 SNP C C ATHBS1 SNP G G A TIE1 SNP A A G TIE1 SNP G G A TLR4 SNP G G A TMED4 SNP AA T TNFAIP8 SNP C C T TNIK SNP G G A TRPC1 SNP G G A TSPAN4 SNP C C TUBA7 SNP A A G USP37 SNP T T C USP4 SNP G G A VPS4A SNP C C T VWA8 SNP TT G WDR78 SNP G G C WIPF1 SNP G G A YPEL4 SNP C C T ZCCHC4 SNP A A GZFHX4 SNP A A G ZMYM6 SNP C C T ZNF215 SNP A A G ZNF219 SNP G G C ZNF28SNP C C T ZNF408 SNP C C T ZNF408 SNP G G T ZNF408 SNP G G T ZNF517 SNPA A G ZNF560 SNP C C T ZNF696 SNP C C T ZNF883 SNP C C A loss_17p CNVNone None None DIS3 SNP C C A FLG SNP C C A MTOR SNP T T C DYSF DEL C C— C1orf141 DEL TTGTCT TTGTCT — NFKBIA DEL TTTTC TTTTC — COL1A1 DEL G G —SIPA1 DEL G G — DPAGT1 DEL A A — PRPSAP1 DEL ACTCT ACTCT — FN3K DEL GAGTGAGT — MGP INS — — T GUCY2D DEL CTG CTG — LMBR1 DEL TATC TATC — COL6A1DEL T T — TRPM4 DEL G G — RP11-295K3.1 DEL CCAGCC CCAGCC — AE000661.50INS — — A C17orf66 INS — — A CLEC17A DEL C C — EXOSC9 DEL CA CA — FARP2INS — — A SON DEL AGGTTAGCTCA AGGTTAGCTCA — GGATCCTTAC GGATCCTTAC NUDT17DEL G G — AKAP12 SNP C C G PLEKHG1 SNP G G A SYNE1 SNP G G C HORMAD2 DELAC AC — ATP8B2 SNP C C T CTD-2090I13.1 SNP C C A LYST SNP A A G EXOC6BINS — — GG ADAMTS13 SNP G G A ADRA1A SNP G G A AGAP1 SNP G G A ALOX15BSNP A A G ALOX15B SNP T T C ASXL3 SNP A A T BAI3 SNP T T C BMP2 SNP C CT C1orf228 SNP G G A C6orf223 SNP C C A CDH23 SNP C C T CHST9 SNP C C GCHSY3 SNP A A T CLCN6 SNP T T A CLCN6 SNP G G T DMXL1 SNP G G T EDC3 SNPT T C FAM160B1 SNP T T G GIMAP7 SNP A A T HERC2 SNP C C T HIST1H2AC SNPG G A HTR7 SNP C C A IGSF9B SNP G G A JUNB SNP G G A KIRREL SNP G G AMAGI2 SNP C C T NLRP5 SNP C C T OAS2 SNP A A G PAX9 SNP G G A PIWIL2 SNPC C A PSG9 SNP G G A SEC11C SNP G G C SEC14L3 SNP A A G SLC18A3 SNP G GT SLC26A9 SNP G G A TMEM91 SNP C C T USP8 SNP C C T XRN1 SNP C C A XRRA1SNP A A T ZNF318 SNP G G A ATM SNP C C T ATM SNP C C T SERPINB13 SNP G GA SF3B1 SNP T T C TP53 SNP G G C gain_1q23.3 CNV None None Nonegain_TERT CNV NA NA NA SFSWAP INS — — CCC loss_10q25.1 CNV NA NA NAgain_6p21.1 CNV NA NA NA gain_22q11.21 CNV NA NA NA gain_MCL1 CNV NA NANA gain_9p24.2 CNV NA NA NA gain_11q13.2 CNV NA NA NA AMOTL1 SNP C C TCADPS2 SNP T T C GAS2L3 SNP C C T IDO1 SNP G G A KBTBD11 SNP G G T NPR2SNP G G A OR10K1 SNP G G T PGBD1 SNP A A G PLCH1 SNP C C A PSMD9 SNP C CT TAPT1 SNP C C T TP53 SNP G G A TSC2 SNP C C T SLC4A4 DEL T T — BAZ2AINS — — A gain_KRAS CNV None None None loss_6q CNV None None None DRG2SNP C C T homdel_2q37.3 CNV None None None gain_AKT3 CNV None None NoneAP000275.65 INS — — GCCTCTGCCT ASCC3 SNP T T C CTNNA2 SNP A A C DST SNPC C A FAM179B SNP A A C MTERFD2 SNP C C T PNLDC1 SNP G G C RASSF8 SNP AA G RDH16 SNP T T G SYNM SNP G G T TCTN2 SNP G G T TRBV25-1 SNP C C ATRIM24 SNP A A G gain_MDM4 CNV NA NA NA gain_11q14.1 CNV NA NA NAloss_9p13.1 CNV NA NA NA gain_19q13.42 CNV NA NA NA gain_11q22.2 CNV NANA NA gain_CCND1 CNV NA NA NA gain_8q21.13 CNV NA NA NA MTMR3 SNP A A TMYPN SNP C C T SPIDR SNP T T G VNN1 SNP A A C ERCC2 SNP G G Chomdel_19q13.32 CNV None None None gain_NKX2-1 CNV NA NA NAhomdel_3p26.3 CNV NA NA NA homdel_11p15.5 CNV None None None gain_5q35.3CNV NA NA NA loss_16q23.1 CNV NA NA NA gain_10p15.1 CNV None None Noneloss_1p36.23 CNV NA NA NA homdel_STK11 CNV None None None gain_ZNF217CNV NA NA NA homdel_BRCA1 CNV NA NA NA gain_3q29 CNV None None NoneFAM13C SNP C C T IGHV1-24 SNP T T C NDUFA9 SNP A A C PABPC4L SNP C C TTDRD9 SNP A A G homdel_16p13.3 CNV None None None homdel_17q25.3 CNVNone None None loss_9q34.3 CNV None None None gain_E2F3 CNV None NoneNone loss_19q CNV None None None loss_19p CNV None None None loss_15qCNV None None None homdel_12q24.33 CNV None None None gain_17q11.2 CNVNone None None gain_13q34 CNV None None None gain_13q CNV None None Noneloss_18p CNV None None None loss_1q44 CNV None None None homdel_4p16.3CNV None None None loss_APC CNV None None None gain_ERBB2 CNV None NoneNone gain_9p CNV None None None homdel_10q26.3 CNV None None Nonegain_NEDD9 CNV None None None homdel_21q22.3 CNV None None Nonehomdel_16q23.1 CNV None None None homdel_IKZF2 CNV None None Nonehomdel_1p36.23 CNV None None None loss_22q CNV None None None AMOTL2 SNPG G A ANAPC4 SNP C C T ANKRD11 SNP G G A BIRC3 SNP G G T C8orf48 SNP G GT CDH11 SNP G G A COL6A5 SNP G G A CORO1A SNP A A G CPEB2 SNP G G ADIRAS3 SNP G G A DNAH9 SNP T T A EGR2 SNP C C T ELP3 SNP G G A ENKD1 SNPC C T ENO2 SNP G G A FLNB SNP A A G FPR2 SNP T T C GABARAPL2 SNP G G TGPR133 SNP C C T HCN1 SNP C C T IGHMBP2 SNP G G A IKBIP SNP C C T INTUSNP G G C IRS2 SNP C C T KIAA0196 SNP G G A MED7 SNP G G C MICAL3 SNP GG A MTMR12 SNP T T C OBSL1 SNP C C A PCGF5 SNP C C G SCO1 SNP G G ASLC12A4 SNP T T G SLC26A8 SNP G G A SNED1 SNP G G A SOX5 SNP G G C SYNE1SNP C C G TACR2 SNP C C T TBX6 SNP G G A TDRD6 SNP G G A TMEM175 SNP G GA UBA52 SNP C C G ZNF408 SNP A A G ATM SNP T T G IRF4 SNP C C A IRF4 SNPT T A TP53 SNP C C T gain_21q CNV NA NA NA homdel_17q25.3 CNV None NoneNone homdel_22q13.32 CNV None None None homdel_19q13.32 CNV None NoneNone homdel_14q32.33 CNV None None None loss_18q23 CNV None None Nonehomdel_17p13.3 CNV None None None gain_1q23.3 CNV None None None NLGN1DEL T T — gain_22q11.21 CNV None None None gain_MDM4 CNV None None Nonehomdel_10q25.1 CNV NA NA NA homdel_STK11 CNV None None Noneloss_12q24.33 CNV NA NA NA homdel_19q13.43 CNV None None Nonehomdel_2q37.3 CNV NA NA NA gain_ZNF217 CNV NA NA NA gain_E2F3 CNV NoneNone None loss_19p CNV None None None homdel_7p22.3 CNV None None Nonegain_4p CNV None None None gain_12q CNV None None None gain_MDM2 CNVNone None None gain_NEDD9 CNV None None None loss_5q35.3 CNV None NoneNone loss_20p CNV None None None gain_8p CNV NA NA NA gain_CCND1 CNV NANA NA homdel_21q22.3 CNV None None None homdel_16q23.1 CNV NA NA NAgain_18q CNV NA NA NA loss_16p CNV None None None loss_11q23.1 CNV NoneNone None NELL1 DEL G G — loss_22q CNV None None None gain_17q24.2 CNVNA NA NA gain_IGF1R CNV None None None loss_MLL3 CNV NA NA NAhomdel_1p36.23 CNV None None None gain_NKX2-1 CNV NA NA NA gain_13q CNVNA NA NA loss_15q15.1 CNV NA NA NA gain_CDK4 CNV None None Noneloss_8p21.2 CNV NA NA NA gain_10p15.1 CNV NA NA NA gain_11q14.1 CNV NANA NA gain_7q36.3 CNV None None None gain_12p CNV None None Nonehomdel_10q26.3 CNV None None None gain_12p13.33 CNV None None Nonegain_9p24.2 CNV NA NA NA homdel_9q34.3 CNV None None None homdel_4p16.3CNV None None None gain_KRAS CNV None None None homdel_5q35.3 CNV NA NANA gain_3q CNV None None None loss_17p CNV None None None loss_4p CNVNone None None gain_5q CNV None None None gain_11q13.2 CNV NA NA NAhomdel_15q15.1 CNV None None None AGXT2 SNR C C A BCL11B SNP G G ABTBD19 SNR G G A CAPRIN2 SNP G G A CDH2 SNP C C T CEP112 SNP G G A CPN1SNP G G A DDX49 SNP G G C DNAH17 SNP C C T DTNA SNP C C T HNF1B SNP C CT HNF4A SNP A A C HTRA3 SNP G G T IL1R2 SNP C C T ITGA4 SNP A A T LAPTM5SNP G G A MAN1B1 SNP G G C NBPF22P SNP G G A NCKAP1 SNP A A T NIPAL4 SNPA A G NRXN2 SNP G G C OBSCN SNP G G A OR4C6 SNP C C A OR4C6 SNP A A GOR4N5 SNP C C T OR52N2 SNP C C G P4HA3 SNP A A G PCSK2 SNP C C T PDCD11SNP A A G PDE6C SNP A A G PDE6H SNP G G A PNOC SNP A A T POU5F1 SNP C CT PRKAA2 SNP C C T RBL2 SNP C C T RPS7 SNP C C T SH3TC2 SNP C C TSLCO3A1 SNP G G A SNAP25 SNP A A C SPATA17 SNP T T A SYNPO2 SNP C C ASYT3 SNP G G A TMEM222 SNP T T C TRIP10 SNP C C T VPS13B SNP A A G VWDESNP T T A WDFY3 SNP T T A ZCCHC10 SNP G G T loss_11q23.1 CNV None NoneNone SF3B1 SNP T T C gain_MCL1 CNV NA NA NA CYB5RL DEL CTCTTGGTAACTCTTGGTAA — gain_8q CNV None None None homdel_STK11 CNV NA NA NA TP53DEL TGTGGAATCAA TGTGGAATCAA — CCCACAGCTGC CCCACAGCTGC ACAGGGCAGGTACAGGGCAGGT CTTGGC CTTGGC homdel_APC CNV NA NA NA gain_IGF1R CNV NA NANA loss_14q32.33 CNV None None None loss_8p CNV None None Nonehomdel_14q32.33 CNV NA NA NA gain_11q22.2 CNV NA NA NA homdel_RB1 CNV NANA NA loss_19q CNV NA NA NA loss_19p CNV NA NA NA loss_6p CNV NA NA NAloss_3p26.3 CNV NA NA NA loss_17p CNV None None None homdel_15q15.1 CNVNone None None EIF4A1 DEL GA GA — Unknown SNP G G A AC015849.16 SNP C CT AC015849.16 SNP A A G AHNAK SNP C C A ANPEP SNP A A T ATP4A SNP G G AB3GALT2 SNP G G T BHLHE40 SNP C C T BUB1 SNP C C A C17orf70 SNP G G AC1orf101 SNP T T C C1orf141 SNP C C A C8orf37 SNP C C T CEP152 SNP T T ACHD2 SNP G G T CHRNB2 SNP G G A COL12A1 SNP T T C CPZ SNP G G A CRIM1SNP T T C CRIP2 SNP G G A DKK3 SNP C C A DNAH8 SNP C C T DOCK1 SNP G G AFAR2 SNP C C A FLNB SNP G G T FTMT SNP C C A GAL3ST2 SNP A A G GIT1 SNPA A T GUCA2A SNP C C T IGHG1 SNP G G C IGHJ6 SNP C C T IGHJ6 SNP C C GIGHM SNP C C T IGHV2-26 SNP G G A IGHV3-23 SNP G G A IGHV3-23 SNP A A GIGHV3-23 SNP C C T IGLV3-21 SNP A A G IGLV3-21 SNP C C A IGLV3-21 SNP CC T IGLV4-3 SNP G G A IGLV4-3 SNP G G C IGLV4-3 SNP C C T IGLV4-3 SNP CC G IGLV4-3 SNP G G T LAMB4 SNP G G A LPPR4 SNP C C T LRP1 SNP C C TMEFV SNP G G A MLH3 SNP G G A MMP16 SNP C C A MYH7 SNP C C T NAALADL2SNP G G A NLRC5 SNP G G A NPAT SNP A A G NRXN3 SNP T T A NUAK1 SNP A A TOR4K14 SNP C C A PAQR4 SNP C C T PCLO SNP C C A PLA2G2E SNP G G T PLCB1SNP G G T PPA1 SNP C C T RAPGEF2 SNP C C A RCC2 SNP G G T REEP6 SNP G GT RGMA SNP G G A RING1 SNP G G A RNF213 SNP G G A SALL1 SNP G G A SCNN1ASNP G G T SLC35E2B SNP C C T SNAP91 SNP C C T SNAP91 SNP A A G SNCAIPSNP G G T SPDYE4 SNP G G A SYMPK SNP C C T TENM3 SNP G G A TIMD4 SNP G GA TMEM178A SNP C C T TMEM216 SNP T T A TMEM242 SNP G G A TMPRSS9 SNP C CT TRIM27 SNP T T C TRIML2 SNP G G A UGT3A1 SNP C C T WDR46 SNP G G CZFP36L2 SNP G G A ZNF488 SNP A A T SF3B1 SNP T T c SF3B1 SNP T T G SF3B1SNP C C A TP53 SNP C C G gain_8q24.3 CNV NA NA NA ADNP2 DEL AG AG —loss_9p21.2 CNV NA NA NA loss_9p21.3 CNV NA NA NA SEC16A DEL CGAGAAGGCGAGAAGG — homdel_14q32.33 CNV None None None loss_18p CNV NA NA NAgain_MYC CNV NA NA NA loss_9q34.3 CNV NA NA NA gain_1q23.3 CNV NA NA NAgain_22q11.21 CNV NA NA NA loss_5p CNV NA NA NA loss_14q CNV NA NA NAloss_5q CNV NA NA NA C5orf45 DEL GGAATGAGATT GGAATGAGATT — CTATGGACTTGCTATGGACTTG GA GA DNAH6 DEL TACAC TACAC — loss_8p11.21 CNV NA NA NAgain_4q CNV NA NA NA gain_4p CNV NA NA NA loss_18q23 CNV NA NA NAloss_9p24.1 CNV NA NA NA ZFC3H1 DEL AAGACAGGGAA AAGACAGGGAA — GCATAGAAGTGCATAGAAGT loss_PARK2 CNV NA NA NA gain_MCL1 CNV NA NA NA LIFR DEL A A —loss_4q CNV NA NA NA gain_8q CNV None None None gain_8p CNV NA NA NAloss_4p CNV NA NA NA gain_10q CNV NA NA NA gain_18p CNV NA NA NA PDE6ADEL CCAGAATTCA CCAGAATTCA — C10orf137 DEL C C — gain_8q23.3 CNV NA NA NAloss_RB1 CNV NA NA NA loss_10q CNV NA NA NA gain_8q22.2 CNV NA NA NAloss_8p CNV NA NA NA RAB4B-EGLN2 DEL AGAG AGAG — gain_13q CNV NA NA NACHD2 DEL G G — DDX11 DEL GTCCCTG GTCCCTG — gain_7q36.3 CNV NA NA NA MYBDEL GTGAC GTGAC — homdel_RB1 CNV None None None gain_6q CNV NA NA NASRSF12 DEL AATACATATAT AATACATATAT GTATAAGCACG GTATAAGCACG CATA CATAgain_7q CNV NA NA NA gain_7p CNV NA NA NA loss_6p CNV NA NA NAloss_17p13.3 CNV None None None loss_17p CNV NA NA NA loss_10p15.3 CNVNA NA NA gain_6p CNV NA NA NA gain_5q CNV NA NA NA loss_21q CNV NA NA NAMTR DEL TAAAA TAAAA — ANGPTL6 SNP C C T BCAR1 SNP G G A BHLHA15 SNP G GA BID SNP C C T C10orf11 SNP C C A C7 SNP G G A CEND1 SNP G G T CXCR2SNP C C T DEFB114 SNP C C T DNAH5 SNP C C T DNHD1 SNP G G A EDNRA SNP CC T EXOC6B SNP A A T GRM5 SNP T T C HADH SNP T T C IRF8 SNP A A T KIF20BSNP A A G LPHN3 SNP G G A MPP5 SNP C C T MT1A SNP G G C MTIF3 SNP C C TNAV2 SNP C C A NCKAP5 SNP G G A NDRG1 SNP C C T PDZRN4 SNP G G A RBM38SNP A A T RD3 SNP G G A RIOK1 SNP A A G ROBO4 SNP G G A SAMHD1 SNP C C TSAMHD1 SNP C C T SEMA4G SNP G G A SEMA6D SNP A A G SLC25A10 SNP G G ASPATS2 SNP C C T TENM2 SNP G G A TMEM176B SNP T T C TMPRSS15 SNP A A GTNIP3 SNP G G A TRAF5 SNP C C G TRBC2 SNP C C T ZNF16 SNP G G T ZNF292SNP C C A ZNF296 SNP G G A ZNF629 SNP G G A FAT1 SNP C C T KEL SNP C C TNRAS SNP T T C loss_14q32.33 CNV None None None SAMHD1 DEL TAGAAGGTAGAAGG — IRF8 DEL TCATTTT TCATTTT — homdel_APC CNV None None Nonehomdel_14q32.33 CNV NA NA NA HAL DEL T T — NOTCH1 DEL AG AG — XPO4 DELCTGAAAT CTGAAAT — SAMHD1 INS — — A RAI1 INS — — G ABCA13 SNP T T C ANO5SNP T T A ASXL3 SNP T T C ATP12A SNP G G A BRSK2 SNP G G C C17orf62 SNPT T C CDK5R1 SNP C C T COL12A1 SNP C C T COX15 SNP G G A CTD-3064M3.7SNP G G A DROSHA SNP C C T DSEL SNP G G T FAM120A SNP G G C FSIP2 SNP TT A GALNT5 SNP G G C GPT SNP G G A GRIK3 SNP G G A IRAK1BP1 SNP A A TMIR518C SNP C C T MYH9 SNP C C T NXF1 SNP T T A OR5AR1 SNP A A G OR5J2SNP A A T PDIA3 SNP A A G PGLYRP3 SNP G G A RCC1 SNP C C T RP11-343C2.12SNP A A G RPL22L1 SNP A A G SLC12A5 SNP C C T SNHG14 SNP G G A TENM3 SNPA A T TOM1L2 SNP G G A TP53 SNP C C A TP53 SNP T T A TRIM37 SNP G G TTRIP4 SNP G G T TUBGCP2 SNP T T C ZNF12 SNP G G A ZNF254 SNP C C GZNF560 SNP G G A loss_14q32.33 CNV None None None PTPN11 SNP A A T SF3B1SNP C C T SF3B1 SNP T T G TP53 SNP G G A TP53 SNP T T A TP53 SNP T T Chomdel_RB1 CNV NA NA NA TC2N INS — — AA gain_22q11.21 CNV NA NA NAloss_11p15.5 CNV None None None SYNE1 INS — — C homdel_APC CNV NA NA NABAZ2A DEL AG AG —

While discrete gene mutations of the target of therapeutic inhibitorshave been long-identified as a common mechanism of resistance totargeted therapies²⁸⁻³⁰, no recurrent mutations of BCL-2 family membershave been yet reported in limited series thus far²⁷, nor withinApplicants' small patient cohort. Rather, Applicants' studies implicatemajor clonal shifts, alterations in the expression profiles of cells,and more complex genomic changes in venetoclax resistance. On the onehand, Applicants' aggregate results underscore that alterations leadingto overexpression of MCL-1, and therefore the ability to sequester BIMand therefore to compensate BCL-2 inhibition, are the most consistentadaptive mechanism of resistance for this drug.^(15,31,32) On the otherhand, Applicants' genome-wide screens together with functionalcharacterization of a resistant cell line have implicated deregulatedmetabolism via altered expression of components of the AMPK signalingpathway in this process. In support of the notion of a dual impact ofvenetoclax on the mitochondria, Applicants notably identified arecurrence of amp(1q), encompassing both MCL1 and the AMPK pathwaycomponent PRKAB2 in both representative cell lines and in patientsamples. Applicants' work thus characterizes venetoclax resistance asinvolving both reprogramming of the outer membrane biology of themitochondria, leading to expression changes in BCL-2 family members, aswell as increased OXPHOS activity which is resident in the organelle'sinner membrane (FIG. 6 e ).

Applicants' findings thus demonstrate that venetoclax imposes a broaderscope of ‘mitochondrial stress’ than previously suggested. Through thislens, Applicants' study casts new light on the mechanisms underlyingdiverse metabolic strategies previously evaluated to overcome resistanceto BCL-2 inhibition, which have included hypoxia 33, caloric restriction4 or the use of the kinase inhibitors (including of AMPK), such assunitinib^(35,36). First, Applicants find that at least in part, theregulation of such optimized metabolism depends on repression of the IDfamily of lymphoid transcriptional regulators. These results mesh wellwith recent work demonstrating that lymphoid transcription factorsfunction as metabolic gatekeepers by limiting the amount of cellular ATPto levels that are insufficient for malignant transformation.²⁰ Hence,although Applicants' studies focused on the impact of ID3, a broaderinvolvement of altered lymphoid differentiation state on venetoclaxresistance is anticipated since repression of additional lymphoidtranscription factors (IKZF5, EP300) were identified in Applicants'knockout screen. Second, Applicants' work adds to the growing evidenceof crosstalk between the BCL-2 family and the mETC. Early studiesdemonstrated that even prior to downstream activation of caspases, theapoptosis program results in a defect in the mETC³⁷. Maintenance of mETCintegrity was recently shown to allow cells to proliferate afterapoptosis induction.³⁸. Conversely, the BCL-2 family proteins canparticipate in non-apoptotic functions such as regulation ofmitochondrial morphology, autophagy or metabolism.³⁹⁻⁴²

These new insights have the potential to provide new therapeuticopportunities. Applicants point out that mutations affecting thesefactors have been detected across B-cell malignancies, and thusApplicants expect them to confer venetoclax resistance. Applicants'findings may therefore guide the further development of BCL-2 inhibitorsin diseases lacking these mutations. Applicants' data support the ideathat targeting MCL-1 with emerging inhibitors would be a rationale andeffective way to counteract venetoclax resistance. Given the associationwith higher OXPHOS status with resistance, this adaptive activity can beexploited to overcome venetoclax resistance.

Methods are provided below.

Human samples. Genomic DNA was isolated (DNAeasy Blood and Tissue Kit,Qiagen) from specimens collected from CLL patients enrolled on clinicaltrials of venetoclax treatment (NCT01328626, NCT02141282), approved byand conducted in accordance with the principles of the Declaration ofHelsinki and with the approval of the Institutional Review Boards (IRB)of the University of Texas/MD Anderson Cancer Center (MDACC; Patients 1,3, 4) or of Dana-Farber Cancer Institute (DFCI; Patient 2, 5, 6). Bloodand/or tissue tumor samples were collected at baseline, beforeinitiation of venetoclax therapy, and at relapse or progression onvenetoclax.

Cells lines. OCI-Ly1 cells (DSMZ, Braunschweig Germany) were cultured inIscove's Modified Dulbecco's Media (Gibco) supplemented with 10% fetalbovine serum (FBS) and 1% penicillin/streptomycin/glutamine. An OCI-Ly1cell line resistant to venetoclax was generated over 10 weeks byexposing the cells to increasing doses of venetoclax starting at 10 nM,and then doubling this dose when the cells were able to grow at a rateequivalent to the parental lines until the cells were able to tolerate 1μM of venetoclax.

Drugs. Venetoclax (ABT-199; Selleck Chemicals), dorsomorphin (Sigma),oligomycin A (Sigma), antimycin A (Sigma), and the MCL-1 inhibitorS63845 (Chemietek) were used for drug treatment experiments. All drugswere resuspended in DMSO (Sigma).

Cell viability assay. The Cell Titer-Glo Luminescent Cell ViabilityAssay (Promega) was used to determine the relative number of viablecells after drug treatment. 0.2×10⁶ cells/mL were seeded in a 24well-plate and treated with drugs for 24 or 48 hours. The viabilityassay was conducted using the manufacturer's protocol after treatment.Values were normalized to DMSO-treated cells. Plates were read on aSpectraMax M3 reader (Molecular Devices).

Western blotting. Total protein from cells was isolated using RIPABuffer (20 mM Tris-HCl pH 7.5, 150 mM NaCl, 1 mM Na₂EDTA, 1 mM EGTA, 1%NP-40, 1% sodium deoxycholate, 2.5 mM sodium pyrophosphate, 1 mM8-glycerophosphate, 1 mM Na₃VO₄, 1 ug/mL leupeptin), supplemented withprotease inhibitors (Thermo Fisher Scientific) and phosphataseinhibitors (Thermo Fisher Scientific). Protein concentration wasdetermined with the BCA Protein Assay (Pierce). Protein samples (25 μg)were separated on either 4-12% Bis-Tris gels (proteins <250 kDa) orTris-acetate gels (proteins >250 kDa). Protein was transferred to anitrocellulose or PVDF membrane (Life Technologies) using the iBlot2system (Life Technologies). Membranes were incubated overnight withprimary antibodies recognizing BCL-2 (1:1000; Abcam), MCL-1 (1:200;Santa Cruz), BCL-XL (1:100; Santa Cruz), BIM (1:1000; Cell SignalingTechnology), BAK (1:1000; Cell Signaling Technology), BAX (1:1000; CellSignaling Technology), Pegasus (1:1000; Santa Cruz), OTUD5 (1:1000; CellSignaling Technology), NOXA (1:100; Santa Cruz), ID3 (1:1000; CellSignaling Technology), ID2 (1:1000; Cell Signaling Technology), p300(1:1000; Santa Cruz), UBR5 (1:1000; Cell Signaling Technology), IκBα(1:1000; Cell Signaling Technology), NF-1 (1:200; Santa Cruz), AMPKα(1:1000; Cell Signaling Technology), PKA beta (1:500, Abcam) and GAPDH(1:1000; Cell Signaling Technology). After incubation in the appropriatesecondary antibodies (anti-rabbit IgG, 1:5000, HRP-linked, Millipore;anti-mouse IgG, 1:1000, HRP-linked, GE Healthcare UK), protein wasdetected using chemiluminescence (Western Lightning Plus-ECL, PerkinElmer).

Genome-scale screens: Conduct of the genome-wide CRISPR-screen. Thestrategy used was similar in approach as previously reported 4. 300×10⁶Cas9-OCI-Ly1 cells were suspended in media supplemented with 8 μg/mLpolybrene and seeded into 9 12-well plates (1 mL per well). Titration ofthe dose of puromycin and of polybrene on OCI-Ly1 cells was undertakento achieve 100% and minimal death of non-infected cells, respectively.The BRUNELLO sgRNA viral library in lentiGuide-puro (GeneticPerturbation Platform, Broad Institute) was added to each well (200μL/mL), titrated to achieve an infection rate of 30% without excessivecell death and to minimize multiplicity of infection. The plates werespun at 2000 rpm for 2 h at 37° C. and incubated at 37° C. for 24 h.Polybrene was diluted by adding 2 mL of standard media to each well.Puromycin selection (1 μg/mL) was initiated 48 hours post-transductionand sustained for 5 days. Two days after puromycin selection, transducedOCI-Ly1 cells were treated with venetoclax (100 nM—a dose identified tobe growth suppressive at day 14) or DMSO as control for 14 days in T225flasks. Cells were counted and re-split every three days, maintaining aconcentration of 200,000 cells/mL Approximately 40 million cells werefrozen before and after venetoclax or DMSO selection for sequencing.This experiment was performed in duplicates.

Genomic DNA (gDNA) was isolated (Maxiprep kits, Qiagen), and PCR andbarcoded sgRNA or ORF-sequencing were performed, as previouslydescribed.⁸ Samples were sequenced on a HiSeq2000 (Illumina). Foranalysis, the read counts were normalized to reads per million and thenlog 2 transformed. The log 2 fold-change of each sgRNAs was determinedrelative to the initial time point for each. Significance of the sgRNAs'enrichment was assessed using the STARS software (v1.3, BroadInstitute).

Conduct of the genome-wide ORF-screen. The approach used was based onprevious reports^(44,45). Optimal transduction conditions weredetermined in order to achieve 30-50% infection efficiency,corresponding to a multiplicity of infection (MOI) of ˜0.5-1. Briefly,1.5×10⁶ of OCI-Ly1 cells were spun-infected in 6 wells of a 12-wellplates with different virus volumes. The day after, OCI-Ly1 cells wereseeded in 2 wells of a 6-well plate, each with complete medium, onesupplemented with 1 μg/mL of puromycin. Cells were counted 4 dayspost-selection to determine the infection efficiency, comparing survivalwith and without puromycin selection. Volumes of virus that yielded˜30-50% infection efficiency were used for screening.

Applicants used an ORFeome barcoded library that contains 17,255barcoded ORFs overexpressing 12,952 unique genes (Broad Institute).Large-scale infections were performed in 12-well format as the viraltitration described above using the optimized volume of virus, andpooled 24 hours post-centrifugation. Infections were performed with anadequate number of cells to achieve a representation of at least 1000cells per ORF following puromycin selection (˜2×10⁷ surviving cellscontaining 17,255 ORFs). ˜24 hours after infection, all wells within areplicate were pooled and were split into T225 flasks. 48 hours afterinfection, cells were selected with puromycin for 72 hours to removeuninfected cells. Seventy-two hours after selection, OCI-Ly1 cells weretreated with either DMSO or 100 nM venetoclax and passaged in freshmedia containing either DMSO or drug every 3-4 days. Cells wereharvested 10 days after initiation of treatment. Isolation of genomicDNA, sequencing and analyses were performed as for the CRISPR-Cas9screen. The log 2 fold-change of each ORF was determined relative to theinitial time point for each. This experiment was performed induplicates.

Generation of CRISPR-Cas9 engineered isogenic cell lines andoverexpression cell lines was as described below.

Cloning of sgRNA vectors. Two of 4 sgRNAs per target were selected fromthe BRUNELLO genome-scale library (based on highest levels ofrepresentation from the genome-wide screen) and related DNAoligonucleotides were synthesized (Gene Link; Table 1), along witholigonucleotides corresponding to 2 control non-targeting sgRNAs pergene. Oligonucleotides were phosphorylated and annealed using T4 PNK(New England Biolabs). The backbone vector (pLKO5.sgRNA.EFS.GFP, Addgene#57822) was digested with FastDigest BsmBI (Thermo Scientific), and thevector and oligonucleotides were ligated with T7 DNA ligase (New EnglandBiolabs). The ligation reaction was treated with Plasmid-Safeexonuclease (Epicentre) to prevent unwanted recombination products. Thefinal product (1 μL) was transformed into 25 μL of DH5a competent cells(New England Biolabs). Colonies were selected and sequenced beforeundergoing plasmid DNA extraction (Endotoxin-Free Plasmid Maxiprep,Qiagen).

Cloning of ORFs vectors. The ORFs for PRKAR2B and PRKAA2 (clone ID:TRCN0000480583 and TRCN0000492160, respectively; Broad Institute GeneticPerturbation Platform ORFeome library(https://portals.broadinstitute.org/gpp/public/)) were cloned into thepLX_TRC317. This is a lentiviral expression vector that encodes apuromycin resistance cassette and an ORF expression cassette undercontrol of the EF1-alpha promoter.

Generation of a Cas9 overexpressing cell line. Stable Cas9-expressingOCI-Ly1 cells were generated by transducing parental cells withlentivirus prepared with lentiCas9-Blast pXR101 (Addgene plasmid#52962)⁴⁶ encoding Cas9 and blasticidin resistance. Selection withblasticidin (10 μg/mL) was initiated 48 h after transduction andsustained throughout culture of Cas9-expressing cell lines. Cas9activity was checked as previously reported by using the pXPR-011 vector(Addgene plasmid #52702).47

Lentivirus production and purification. To produce lentivirus, ˜800,000HEK293T cells were seeded per well in a 6-well plate in 2.7 mL ofantibiotic-free DMEM supplemented with 10% FBS. For each well, 150 μL ofOptiMEM (Life Technologies) was mixed with 5 μg of pLKO5_sgRNA plasmid,0.4 μg of pVSV.G, and 1.5 μg of psPAX2 (Addgene #12260). Separately, 9μl of Lipofectamine 2000 (Life Technologies) was diluted in 150 μlOptiMEM. After a 15 min incubation at room temperature, the DNA andLipofectamine mixes were combined and incubated together at roomtemperature for 30 min before being added to the cells. After 12 h, themedia was changed to DMEM supplemented with 20% FBS. 48 hpost-transfection, 3 mL of media was removed and filtered through a 0.45μm low protein binding membrane (Millipore Steriflip HV/PVDF) and addedto 1 mL of LentiX Concentrator (Clontech). This mixture was thenincubated at 4° C. for 2 h, and centrifuged at 1500×g for 45 min at 4°C. The pellet was resuspended in 100 μL of PBS and stored in aliquots at−80° C.

Generation of engineered cell lines. 0.5×10⁶ target OCI-Ly1 cells weresuspended in media supplemented with 8 μg/mL polybrene and seeded into6-well plates (1 mL per well), to which lentivirus was added (50 μL/mLto each well). The plates were spun at 2000 rpm for 2 h at 37° C. andincubated at 37° C. for 24 h. The polybrene-containing media was thenreplaced by 2 mL of fresh media per well. After 3 days, transduced cellswere selected (i.e. by puromycin (1 μg/mL) for 1 week for theORF-overexpressing cells) or sorted (i.e. based GFP or mCherryexpression for the CRISPR gene-edited lines) and cryopreserved forfurther experiments. As confirmation that the engineered cell linesexpressed the expected alterations, Applicants: (i) evaluated theexpression of the targeted protein by western-blotting (FIG. 6 d ), and(ii) for the CRISPR-Cas9 engineered cell lines, performed targeted DNAsequencing for the CRISPR target sites before and after 2 weeks ofexposure to venetoclax (100 nM), and assessed the proportion offrameshift indels (FIG. 6 g ). In brief, Applicants used a two-steptouchdown PCR protocol. Genomic DNA from the pre- and post-treatedsamples was PCR-amplified using KAPA HiFi DNA polymerase and primersspecific for the target sequence of the gRNAs. Products from the firstreaction were barcoded with Illumina sequencing adaptor sequences andindexes during a second round of PCR. Following PCR, samples werepurified with Agencourt AMPure XP beads (Beckman Coulter) and quantifiedon a Bioanalyzer (Agilent) with High Sensitivity DNA chips. Samplelibraries were diluted to 4 nM, pooled, and ran on the Illumina MiSeqplatform using single-end sequencing with the following parameters: read1: 296nt, index 1: 6nt.

Single-cell cloning of the ID3 knockout. OCI-Ly1 cells was performedusing dose-limiting dilution strategy. Cells from the bulk ID3 OCI-Ly1were seeded at a concentration of 0.5 cells/well in a 96-well plate (5plates per cell line). To investigate the presence of mutations, 6clones per sgRNA were analyzed by PCR and Sanger sequencing usingprimers flanking the target sites for the sgRNAs (Forward primer:5′-TGACAAGTTCCGGAGTGAGC-3′ (SEQ ID NO:1);Reverse:5′-CGGTATCAGCGCTTCCTCAT-3′ (SEQ ID NO:2)). The absence of ID3protein were confirmed in clones harboring loss-of-function mutations bywestern blot (FIG. 8 d ). Three different knockout single-cell clonesfor each sgRNA were used for further functional studies.

Whole-exome sequencing and data analyses. Library construction from CLLand matched germline DNA of Patients 1-6 was performed as previouslydescribed 48, with the following modifications: (i) initial genomic DNAinput into shearing was reduced from 3 μg to 10-100 ng in 50 μl ofsolution; (ii) for adapter ligation, Illumina paired-end adapters werereplaced with palindromic forked adapters (from Integrated DNATechnologies), with unique dual-indexed molecular barcode sequencesincluded in the adapter sequence to facilitate downstream pooling. Withthe exception of the palindromic forked adapters, the reagents used forend repair, A-base addition, adapter ligation and library enrichment PCRwere purchased from KAPA Biosciences in 96-reaction kits, (iii) duringthe post-enrichment solid-phase reversible immobilization (SPRI)cleanup, elution volumes were reduced to 30 μL to maximize libraryconcentration, and a vortexing step was added to maximize the amount oftemplate eluted. Any libraries with concentrations below 40 ng/ml (perPicoGreen assay, automated on an Agilent Bravo) were considered failuresand reworked from the start of the protocol. Following libraryconstruction, hybridization and capture were performed using therelevant components of Illumina's Nextera Rapid Capture Exome Kit andfollowing the manufacturer's suggested protocol. with the followingexceptions: first, all libraries within a library construction platewere pooled prior to hybridization. Second, the Midi plate fromIllumina's Nextera Rapid Capture Exome Kit was replaced with a skirtedPCR plate to facilitate automation. All hybridization and capture stepswere automated on the Agilent Bravo liquid handling system. Afterpost-capture enrichment, library pools were quantified using qPCR(automated assay on the Agilent Bravo), using a kit purchased from KAPABiosystems with probes specific to the ends of the adapters. On thebasis of qPCR quantification, libraries were normalized to 2 nM, andthen denatured using 0.1N NaOH on the Hamilton Starlet. Afterdenaturation, libraries were diluted to 20 pM using hybridization bufferpurchased from Illumina.

Cluster amplification of denatured templates was performed according tothe manufacturer's protocol (Illumina) using HiSeq 4000 clusterchemistry and HiSeq 4000 flowcells. The flowcells are then analyzedusing RTA v.1.18.64 or later. Each pool of whole exome libraries was runon paired 76 bp runs, reading the dual-indexed sequences to identifymolecular indices and sequenced across the number of lanes needed tomeet coverage for all libraries in the pool.

Alignments to hg19 using bwa version 0.5.9-r16⁴⁹ and quality controlwere performed using the Picard (http://picard.sourceforge.net/) andFirehose (pipelines at the Broad Institute). Firehose is a frameworkcombining workflows for the analysis of cancer-sequencing data. Theworkflows perform quality control, local re-alignment, mutation calling,small insertion and deletion identification, rearrangement detection andcoverage calculations, among other analyses. A dbGaP accession numberfor the depositing of WES data for this study is pending.

Identification of somatic mutations. Sequencing output was processedwith the Picard and GATK toolkits developed at the Broad Institute, aprocess that involves marking duplicate reads, recalibrating basequalities and realigning around somatic small insertions and deletions(sINDELs). All BAM files were generated by aligning with bwa version0.5.9 to the NCBI Human Reference Genome Build hg19. Prior to variantcalling, the impact of oxidative damage (oxoG) and FFPE damage to DNAduring sequencing was quantified according to Costello et al.⁵⁰ Thecross-sample contamination was measured with ContEst based on the allelefraction of homozygous SNPs⁵¹, and this measurement was used in MuTect.From the aligned BAM files, somatic alterations were identified using aset of tools developed at the Broad Institute(www.broadinstitute.org/cancer/cga). The details of Applicants'sequencing data processing have been described elsewhere^(52,53).

Following Applicants' standard procedure, sSNVs were detected usingMuTect⁹ (version 1.1.6); sINDELs were detected using Strelka⁵⁴.Applicants then applied a stringent set of filters to improve thespecificity of Applicants' sSNV and sINDEL calls and remove likely FFPEartifacts. Applicants applied an allele fraction specificpanel-of-normals filter, which compares the detected variants to a largepanel of normal exomes and removes variants that were observed in thepanel-of-normals. Applicants then applied a realignment based filter,which removes variants that can be attributed entirely to ambiguouslymapped reads. All filtered events in candidate CLL genes were alsomanually reviewed using the Integrated Genomics Viewer (IGV)⁵⁵. In thematched sample sets from 6 individuals, Applicants utilized “forcedcalling” to quantify the number of reads supporting the alternate andreference alleles at sites which were detected in any sample from thatindividual. Estimation of and correction for tumour contamination innormal was performed using the deTiN algorithm⁵⁶ to recover somaticmutations that would have otherwise been filtered out due to evidence ofthe mutation in the normal. To address the lack of a matched normalsample (in Patient 3) Applicants used a stringent panel-of-normals andpopulation allele frequency criteria, and excluded non-coding variantsfrom analysis. To address the lack of a matched normal sample (inPatient 6), Applicants used a stringent panel-of-normals and populationallele frequency criteria, and excluded non-coding variants fromanalysis. Furthermore, parental OCI-Ly1-S cells were used as a sourcecontrol DNA in order to highlight sSNVs that were acquired in theresistant OCI-Ly1-R cells. Reference lists for sSNVs and sINDELs inknown putative CLL driver genes as well as for recurrent CNAs wereconcatenated based on previous sequencing studies of large CLLcohorts⁵⁷⁻⁶¹. Total copy number was measured using ReCapSeg(www.broadinstitute.org/cancer/cga), then segmented into allelic copynumber with AllelicCapSeg⁶² based on heterozygous germline sitesdetected with HaplotypeCaller according to the protocol describedpreviously (http://archive.broadinstitute.org/cancer/cga/acsbeta).

Estimation of mutation cancer cell fraction using ABSOLUTE and clonalevolution mapping. The cancer cell fraction (represented as aprobability density distribution∈[0, 1]) of individual somaticalterations were estimated using the ABSOLUTE algorithm (v1.5) whichcalculates the sample purity, ploidy, and local absolute DNA copy-numberof each mutation, as previously described^(59,63). CCFs were clusteredas previously described⁵⁹ to delineate distinct subclonal populations.Phylogenetic relationships between these populations were inferred usingpatterns of shared mutations and CCF using the PhylogicNDT analysis.

RNA sequencing and cDNA Library Construction. Total RNA was quantifiedusing the Quant-iT™ RiboGreen® RNA Assay Kit and normalized to 5 ng/μl.Following plating, 2 μL of ERCC controls (using a 1:1000 dilution) werespiked into each sample. An aliquot of 200 ng for each sample wastransferred into library preparation which uses an automated variant ofthe Illumina TruSeq™ Stranded mRNA Sample Preparation Kit. This methodpreserves strand orientation of the RNA transcript. It uses oligo dTbeads to select mRNA from the total RNA sample, followed by heatfragmentation and cDNA synthesis from the RNA template. The resultant400 bp cDNA then goes through dual-indexed library preparation: ‘A’ baseaddition, adapter ligation using P7 adapters, and PCR enrichment usingP5 adapters. After enrichment, the libraries were quantified usingQuant-iT PicoGreen (1:200 dilution). After normalizing samples to 5ng/μL, the set was pooled and quantified using the KAPA LibraryQuantification Kit for Illumina Sequencing Platforms. The entire processwas in a 96-well format and all pipetting is done by either AgilentBravo or Hamilton Starlet.

Illumina Sequencing. Pooled libraries were normalized to 2 nM anddenatured using 0.1 N NaOH prior to sequencing. Flowcell clusteramplification and sequencing were performed according to themanufacturer's protocols using either the HiSeq 2000 or HiSeq 2500instrument. Each run generated a 101 bp paired-end with an eight-baseindex barcode read. Data was analyzed using the Broad Picard Pipeline,which includes de-multiplexing and data aggregation.

Data analyses. RNA-seq data were aligned to GRCh38.p5 withSTAR-2.5.1b.⁶⁴ Gene expression was quantified with RSEM-1.2.31.⁶⁵DESeq2⁶⁶ was applied to call differentially expressed genes between eachcell line and control group. Pathway enrichment analysis was performedwith GSEA⁶⁷ in GenePattern.⁶⁸ Heatmap and Volcano plots were generatedusing R software.

Mass spectrometry-based proteome investigations: In Solution Digestion.OCI-Ly1 cell pellets were lysed at 4° C. in 8 M urea, 50 mM Tris-HCl pH8.0, 150 mM NaCl, 1 mM EDTA, 2 μg/μl aprotinin (Sigma-Aldrich), 10 μg/μlleupeptin (Roche), and 1 mM phenylmethylsulfonyl fluoride (PMSF)(Sigma). Protein concentration was determined using a bicinchoninic acid(BCA) protein assay (Pierce). Proteins were reduced with 5 mM (DTT) for45 min at room temperature (RT), followed by alkylation with 10 mMiodoacetamide for 30 min at room temperature in the dark. Ureaconcentration was reduced to 2 M with 50 mM Tris-HCl, pH 8. Samples werepre-digested for 2 h at 30° C. with endoproteinase Lys-C (WakoLaboratories) at an enzyme-to-substrate ratio of 1:50. Samples weredigested overnight at 37° C. with sequencing grade trypsin (Promega) atan enzyme-to-substrate ratio of 1:50. Following overnight digest,samples were acidified with neat formic acid to a final concentration of1%. Acidified samples were subsequently desalted on a 100 mg tC18Sep-Pak SPE cartridge (Waters). Briefly, cartridges were conditionedwith 1 mL of 100% MeCN, 1 mL of 50% MeCN/0.1% FA, and 4× with 1 mL of0.1% TFA. The sample was loaded, and washed 3× with 1 mL of 0.1% TFA, lxwith 1 mL of 1% FA, and eluted 2× with 600 μl of 50% MeCN/0.1% FA.Following desalting, 100 μg of the sample was dried to completion andstored at −80° C.

TMT labeling of peptides. Desalted peptides were labeled with TMT10-plex isobaric mass tagging reagents (Thermo Fisher Scientific) aspreviously described⁶⁹. Each TMT reagent was resuspended in 41 μL ofMeCN. Peptides were resuspended in 100 μL of 50 mM HEPES and combinedwith TMT reagent. Samples were incubated at RT for 1 h while shaking.The TMT reaction was quenched with 8 μL of 5% hydroxylamine at RT for 15min with shaking. TMT labeled samples were combined, dried tocompletion, reconstituted in 100 μL of 0.1% FA, and desalted onStageTips or 100 mg SepPak columns as described above.

Basic Reverse Phase (bRP) Fractionation. The TMT labeled samples werefractionated using offline high pH reversed-phase chromatography (bRP)as previously described⁶⁹. Samples were fractionated using Zorbax 300Extend C18 column (4.6×250 mm, 300 Å, 5 μm, Agilent) on an Agilent 1100series high-pressure liquid chromatography (HPLC) system. Samples werereconstituted in 900 μL of 5 mM ammonium formate (pH 10.0)/2% (vol/vol)acetonitrile (MeCN) (bRP solvent A). Samples were injected with SolventA at a flow rate of 1 mL/min and separated using a 96 min gradient. Thegradient consisted of an initial increase to 16% solvent B (90% MeCN, 5mM ammonium formate, pH 10), followed by 60 min linear gradient from 16%solvent B to 40% B and successive ramps to 44% and 60% at a flow rate of1 mL/min. Fractions were collected in a 96-deep well plate (GEHealthcare) and pooled in a non-contiguous manner into final 24 proteomefractions. Pooled fractions were dried to completeness using a SpeedVacconcentrator.

Liquid chromatography and mass spectrometry. Desalted peptides wereresuspended in 9 μL of 3% MeCN/0.1% FA and analyzed by online nanoflowliquid chromatography tandem mass spectrometry (LC-MS/MS) usingQ-Exactive+mass spectrometer (Thermo Fisher Scientific) coupled on-lineto a Proxeon Easy-nLC 1200 (Thermo Fisher Scientific) as previouslydescribed⁶⁹. Briefly, 4 μL of each sample was loaded onto amicrocapillary column (360 m outer diameter×75 m inner diameter)containing an integrated electrospray emitter tip (10 m), packed toapproximately 22 cm with ReproSil-Pur C18-AQ 1.9 μm beads (Dr. MaischGmbH) and heated to 50° C. Samples were analyzed with 110 min method.The 110 min method contained a mobile phase with a flow rate of 200nL/min, comprised of 3% acetonitrile/0.1% formic acid (Solvent A) and90% acetonitrile/0.1% formic acid (Solvent B), with the followinggradient profile: (min:% B) 0:2; 1:6; 85:30; 94:60; 95:90; 100:90;101:50; 110:50 (the last two steps at 500 nL/min flow rate). TheQ-Exactive+MS was operated in the data-dependent mode acquiring HCDMS/MS scans (r=35,000) after each MS1 scan (r=70,000) on the 12 mostabundant precursor ions using an MS1 target of 3×10⁶ and an MS2 targetof 5×10⁴. The maximum ion time utilized for MS/MS scans was 120 ms; theHCD-normalized collision energy was set to 30; the dynamic exclusiontime was set to 20 s, isotope exclusion function was enabled, andpeptide match function was set to preferred. Charge exclusion wasenabled for charge states that were unassigned, 1 and >6.

Data Analysis. All data were analyzed using Spectrum Mill softwarepackage v 6.1 pre-release (Agilent Technologies). Similar MS/MS spectraacquired on the same precursor m/z within +/−60 s were merged. MS/MSspectra were excluded from searching if they were not within theprecursor MH+ range of 750-4000 Da or if they failed the quality filterby not having a sequence tag length >0. MS/MS spectra were searchedagainst UniProt human database. All spectra were allowed +/−20 ppm masstolerance for precursor and product ions, 30% minimum matched peakintensity, and “trypsin allow P” enzyme specificity with up to 2 missedcleavages. The fixed modifications were carbamidomethylation atcysteine, and TMT at N-termini and internal lysine residues. Variablemodifications included oxidized methionine and N-terminal proteinacetylation. Individual spectra were automatically designated asconfidently assigned using the Spectrum Mill autovalidation module.Specifically, a target-decoy based FDR scoring threshold criteria via atwo-step auto threshold strategy at the spectral and protein levels wasused. First, peptide mode was set to allow automatic variable rangeprecursor mass filtering with score thresholds optimized to yield aspectral level FDR of <1.2%. A protein polishing autovalidation wasapplied to further filter the peptide spectrum matches using a targetprotein-level FDR threshold of 0. Following autovalidation, aprotein-protein comparison table was generated, which containedexperimental ratios. For all experiments, non-human contaminants andreversed hits were removed. Furthermore, data were filtered to onlyconsider proteins with 2 or more unique peptides and was mediannormalized.

For statistical analysis, a moderated t-test was implemented in R-Shinyusing the limma R library. Correction for multiple testing was performedusing the Benjamini-Hochberg false discovery rate method.

Measurement of oxygen consumption and extracellular acidification rate.For each condition, 1.25×10⁵ cells were counted and plated on a Seahorseplate coated with Cell-Tak (Corning Life Sciences) in Seahorse XF DMEMmedia (Agilent). OCR and ECAR were recorded using a Seahorse XF96Analyzer (Agilent) for 24 consecutive measurements. OCR is measuredbefore and after the addition of inhibitors to assess mitochondrialfunction by deriving several parameters of mitochondrial respiration:(i) basal respiration, (ii) ATP-linked respiration and proton leakrespiration (after 3 μM oligomycin [Sigma], a complex V inhibitor) and(iii) maximal respiration (after 1 μM carbonyl cyanide m-chlorophenylhydrazine (CCCP) [Sigma], a protonophore). Mitochondrial respiration isfinally inhibited by 1 μM antimycin A (Sigma), a complex III inhibitor.

To measure the effect of venetoclax on OCR/ECAR, cells were pre-treatedfor 1 h with 10 M of zVAD-FMK (Abcam) or left untreated and OCR/ECARwere recorded for 4 measurements before injection of venetoclax at afinal concentration of 100 nM. DMSO injection was used as control.

Mitochondrial DNA copy number. Relative mtDNA copy number was determinedusing a multiplexed qPCR assay previously reported⁷⁰.

Measurement of mitochondrial superoxide levels. To measure relativelevels of mitochondrial superoxide, cells were stained with 5 μM MitoSOXRed (Invitrogen, cat #M36008) for 10 min at 37° C. Cells were thenwashed three times with the media. Using a flow cytometer (FACSymphony,BD), MitoSOX Red was excited at 488 nm and fluorescence emission at610/20 nm (BB630) was measured. Relative fluorescence intensity frombiological triplicate of 10,000 cells were used as an indicator ofmitochondrial superoxide levels.

Mitochondrial membrane potential. Cells were stained with 2.5 μM JC-1(ThermoFisher Scientific, cat #T3168) for 30 min at 37° C. Cells werethen washed three times with the media and subjected to the flowcytometry (FACS-Canto) following manufacturer instruction. Briefly, JC-1was excited at 488 nm and its emission at both 525 nm (FITC-A) and 585nm (PE-A) were measured. By comparing the ratio of emission at 585nm/525 nm, relative levels of mitochondrial membrane potential weredetermined from 10,000 cells in biological triplicate.

Statistical analysis. Data analyses were carried out using GraphPadPrism version 7 and R software. The data are summarized as mean±s.e.m.or s.d. as indicated, and are presented as individual values as scatterplots with column bar graphs and were analyzed using Student's t-tests(two-sided). One-way ANOVA was used to compare three or more groups intime point analyses. Differences were considered significant whenP<0.05.

Synergy analysis for venetoclax drug combinations were performed usingthe Chou-Talalay method based on the median-effect principle.⁷¹Combination index values and isobolograms were generated using CompuSyn.

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Various modifications and variations of the described methods,pharmaceutical compositions, and kits of the invention will be apparentto those skilled in the art without departing from the scope and spiritof the invention. Although the invention has been described inconnection with specific embodiments, it will be understood that it iscapable of further modifications and that the invention as claimedshould not be unduly limited to such specific embodiments. Indeed,various modifications of the described modes for carrying out theinvention that are obvious to those skilled in the art are intended tobe within the scope of the invention. This application is intended tocover any variations, uses, or adaptations of the invention following,in general, the principles of the invention and including suchdepartures from the present disclosure come within known customarypractice within the art to which the invention pertains and may beapplied to the essential features herein before set forth.

1. A method of inhibiting tumor growth of a BCL-2-driven cancer in asubject in need thereof, increasing sensitivity of a cell or populationof cells to a BCL-2 inhibitor, or decreasing a BCL-2 inhibitorresistance signature of a cell or population of cells comprisingadministering to the subject, cell or population of cells: one or moreagents capable of inhibiting the oxidative phosphorylation system(OXPHOS); or one or more agents that induces or enhances expression,activity, and/or function of one or more BCL-2 inhibitor resistancesignature genes selected from the group consisting of those listed inTable 1, downregulated genes in Table 3, and/or downregulated genes inTable 4: or an agent that inhibits expression, activity, and/or functionof one or more BCL-2 inhibitor resistance signature genes selected fromthe group consisting of those listed in Table 2, upregulated genes inTable 3, and/or upregulated genes in Table 4, preferably, atherapeutically effective amount of one or more agents; or a combinationtherapy comprising an inhibitor of BCL-2 and one or more NF kappa Binhibitors.
 2. The method of claim 1, wherein the method comprisesadministering to the subject a combination therapy comprising aninhibitor of BCL-2 and one or more inhibitors selected from the groupconsisting of an AMPK inhibitor and mitochondrial electron transportchain (mETC) inhibitor, preferably, wherein the BCL-2 inhibitor isVenetoclax; and/or wherein the AMPK inhibitor is dorsomorphin (compoundC); and/or wherein the mitochondrial electron transport chain (mETC)inhibitor comprises oligomycin or antimycin.
 3. (canceled)
 4. (canceled)5. (canceled)
 6. (canceled)
 7. The method of claim 1, wherein the one ormore agents increase expression, activity, and/or function of one ormore target genes or one or more products of one or more target genesselected from the group consisting of: a. PMAIP1, BAX, NFKBIA, IKZF5,BAK1, ID3, EP300, ZEB2, NFIA, BCL2L11 and OTUD5; or b. FNBP1, CD9,PLXNB2, TTC39C and DENND3; or c. XBP1, CYBB, PAG1 and DIRAS1; or d. CD9,PLXNB2, TTC39C, DENND3, ICAM1, GNG7, ID2, FNBP1, FBP1, ACY3, CDKN1A,GALM, PTK2 and CYBB.
 8. The method of claim 1, wherein the one or moreagents decrease expression, activity, and/or function of one or moretarget genes or one or more products of one or more target genesselected from the group consisting of: a. BCL2L1, BCL2L2, BCL2, MCL1,SRPX, RNF26, HSPB9, OR1S2, ADIPOQ, PIGF, CSGALNACT1, OTUD6A, SLC25A3,PRKAR2B, DNM2, SPHAR, APOBEC3C, RPL17, INMT, THADA, SBNO2, PRKAA2,BRMS1L, TRNAU1AP, CNNM3, ADAM33, PRKD2, FCHSD2, LOC399886, BABAM1,C1orf146, LMAN2L, ZNF460, TEX2, YRDC, ARHGAP11A, SPEG, FBXO9, USP54,SLC22A6, RPS4Y1, FAM71C, SH3BGRL2, HCRTR1, BST1, PHF10, UCKL1, ATG5,RPS15A, CDCl20B, PPIE, TUT1, RPL36, HSD11B1L, MTERF4, PTS, S1PR4, HJURP,HMMR, BOLA2, DNASE1L1, OSGEP, TMBIM4, BTNL3, CHRM3, FBX015, KLK8, ASPN,STYK1 and SRSF6; or b. SYT11, PARM1, ROBO2, CD48, FCRL1 and MCL1; or c.PLCL2, KCNA3, TNFRSF21, CYP2U1, TRAM2 and RAPGEF5; or d. TSTD1, DNAJC12,TRAF3IP3, OPTN, DOCK10, PYHINI, CD48, P4HA2, PLCL2, AOX1, CDK6, GATM,GLUL, PAPSS1, MCL1 and GATM.
 9. The method of claim 1, wherein the tumoroverexpresses BCL-2; and/or wherein the tumor is resistant to aninhibitor of BCL-2; and/or wherein the tumor is resistant to Venetoclax.10. (canceled)
 11. (canceled)
 12. The method of claim 1, furthercomprising administering to said subject a therapeutically effectiveamount of an inhibitor of BCL-2, preferably, wherein the inhibitor ofBCL-2 is Venetoclax.
 13. (canceled)
 14. (canceled)
 15. The method ofclaim 1, wherein the NF kappa B inhibitor is selected from the groupconsisting of denosumab, disulfiram, olmesartan, dithiocarbamates,anatabine, BAY 11-7082 and iguratimod.
 16. (canceled)
 17. (canceled) 18.(canceled)
 19. The method of claim 1, wherein the one or more agentsenhance expression, activity, and/or function of one or more genesselected from the group consisting of: a) PMAIP1, BAX, BAK1, orBCL-2L11, b) NFKBIA, IKZF5, ID3, EP300, NFIA, OTUD5, or UBR5; or c)FNBP1, CD9, PLXNB2, TTC39C, DENND3, XBP1, CYBB, PAG1, DIRAS1, ICAM1,GNG7, ID2, FBP1, ACY3, CDKN1A, GALM or PTK2; or decrease expression,activity, and/or function of one or more genes selected from the groupconsisting of: a) BCL2L1, BCL2L12, BCL2 or MCL1, b) ADIPOQ, PRKAR2B,PRKAA2, SLC25A3, RFN26, DNM2, PRKD2, ATG5, RPL17, RPS4Y1, RPS15A,OUTUD6A, FBXO9, or USP54, or c) SYT11, PARM1, ROBO2, CD48, FCRL1, MCL1,PLCL2, KCNA3, TNFRSF21, CYP2U1, TRAM2, RAPGEF5, TSTD1, DNAJC12,TRAF3IP3, OPTN, DOCK10, PYHINI, CD48, P4HA2, AOX1, CDK6, GATM, GLUL,PAPSS1 or GATM.
 20. A method of screening for one or more agents thatincreases a BCL-2 inhibitor sensitive signature or decreases a BCL-2inhibitor resistance signature of a cell or a population of cells thatexpresses BCL-2 comprising: delivering to the cell one or more candidateagents and selecting one or more agents that increases expression,activity, and/or function of one or more target genes or one or moreproducts of one or more genes selected from the group consisting ofthose listed in Table 1, downregulated genes in Table 3, and/ordownregulated genes in Table 4; or decreases expression, activity,and/or function of one or more target genes or one or more products ofone or more target genes selected from the group consisting of thoselisted in Table 2, upregulated genes in Table 3, and/or upregulatedgenes in Table
 4. 21. The method of claim 20, wherein the one or morecandidate agents increase expression, activity, and/or function of oneor more target genes or one or more products of one or more target geneswhich comprise inhibitors of the NF-Kappa B pathway, lymphoidtranscription factors and modulators, ubiquitination components, and/orpro-apoptotic BCL-2 family proteins; or wherein the one or morecandidate agents decrease expression, activity, and/or function of oneor more target genes or one or more products of one or more target geneswhich comprise energy-stress sensor signaling pathway components, amitochondrial energy metabolism component, vesicle transport/autophagycomponents, ribosomal components, and/or ubiquitination components; orwherein the one or more candidate agents increase expression, activity,and/or function of one or more target genes or one or more products ofone or more target genes selected from the group consisting of: a.PMAIP1, BAX, NFKBIA, IKZF5, BAK1, ID3, EP300, ZEB2, NFIA, BCL2L11 andOTUD5; or b. FNBP1, CD9, PLXNB2, TTC39C and DENND3; or c. XBP1, CYBB,PAG1 and DIRAS1: or d. CD9, PLXNB2, TTC39C, DENND3, ICAM1, GNG7, ID2,FNBP1, FBP1, ACY3, CDKN1A, GALM, PTK2 and CYBB; or wherein the one ormore candidate agents decrease expression, activity, and/or function ofone or more target genes or one or more products of one or more targetgenes selected from the group consisting of: a. BCL2L1, BCL2L2, BCL2,MCL1, SRPX, RNF26, HSPB9, OR1S2, ADIPOQ, PIGF, CSGALNACT1, OTUD6A,SLC25A3, PRKAR2B, DNM2, SPHAR, APOBEC3C, RPL17, INMT, THADA, SBNO2,PRKAA2, BRMS1L, TRNAU1AP, CNNM3, ADAM33, PRKD2, FCHSD2, LOC399886,BABAM1, C1orf146, LMAN2L, ZNF460, TEX2, YRDC, ARHGAP11A, SPEG, FBXO9,USP54, SLC22A6, RPS4Y1, FAM71C, SH3BGRL2, HCRTR1, BST1, PHF10, UCKL1,ATG5, RPS15A, CDC20B, PPIE, TUT1, RPL36, HSD11B1L, MTERF4, PTS, S1PR4,HJURP, HMMR, BOLA2, DNASE1L1, OSGEP, TMBIM4, BTNL3, CHRM3, FBX015, KLK8,ASPN, STYK1 and SRSF6; or b. SYT11, PARM1, ROBO2, CD48, FCRL1 and MCL1;or c. PLCL2, KCNA3, TNFRSF21, CYP2U1, TRAM2 and RAPGEF5; or d. TSTD1,DNAJC12, TRAF3IP3, OPTN, DOCK10, PYHINI, CD48, P4HA2, PLCL2, AOX1, CDK6,GATM, GLUL, PAPSS1, MCL1 and GATM.
 22. (canceled)
 23. (canceled) 24.(canceled)
 25. The method of claim 20, wherein the cell or population ofcells overexpresses BCL-2.
 26. The method of claim 20, wherein themethod further comprises exposing the cell or population of cells to anagent that modulates the expression or activity of at least one BCL-2antagonist of cell death (BAD) pathway component, preferably, whereinthe method further comprises exposing the cell or population of cells toan agent that inhibits BCL-2, more preferably, wherein the agent thatinhibits BCL-2 is Venetoclax.
 27. (canceled)
 28. (canceled)
 29. Themethod of claim 1, wherein the agent is a small molecule, small moleculedegrader, genetic modifying agent, antibody, antibody fragment,antibody-like protein scaffold, aptamer, protein, or any combinationthereof.
 30. The method of claim 29, wherein the genetic modifying agentcomprises a CRISPR system, RNAi system, a zinc finger nuclease system, aTALE system, or a meganuclease, preferably, wherein the CRISPR systemcomprises a Class 2, Type II, V, or VI CRISPR-Cas system; or wherein theCRISPR system comprises a dCas fused or otherwise linked to a nucleotidedeaminase, more preferably, wherein the nucleotide deaminase is acytidine deaminase or an adenosine deaminase.
 31. (canceled) 32.(canceled)
 33. (canceled)
 34. A method of detecting a BCL-2 inhibitorresistance signature in a subject in need thereof comprising detectingin a tumor sample obtained from the subject the expression of one ormore genes selected from the group consisting of those listed in Table1, Table 2, Table 3, and/or Table
 4. 35. The method of claim 34, whereinthe genes selected from the group consisting of: a. PMAIP1, BAX, NFKBIA,IKZF5, BAK1, ID3, EP300, ZEB2, NFIA, BCL2L11 and OTUD5; or b. FNBP1,CD9, PLXNB2, TTC39C and DENND3; or c. XBP1, CYBB, PAG1 and DIRAS1; or d.CD9, PLXNB2, TTC39C, DENND3, ICAM1, GNG7, ID2, FNBP1, FBP1, ACY3,CDKN1A, GALM, PTK2 and CYBB, are downregulated as compared to areference value; or wherein the genes selected from the group consistingof: a. BCL2L1, BCL2L2, BCL2, MCL1, SRPX, RNF26, HSPB9, OR1S2, ADIPOQ,PIGF, CSGALNACT1, OTUD6A, SLC25A3, PRKAR2B, DNM2, SPHAR, APOBEC3C,RPL17, INMT, THADA, SBNO2, PRKAA2, BRMS1L, TRNAU1AP, CNNM3, ADAM33,PRKD2, FCHSD2, LOC399886, BABAM1, C1orf146, LMAN2L, ZNF460, TEX2, YRDC,ARHGAP11A, SPEG, FBXO9, USP54, SLC22A6, RPS4Y1, FAM71C, SH3BGRL2,HCRTR1, BST1, PHF10, UCKL1, ATG5, RPS15A, CDC20B, PPIE, TUT1, RPL36,HSD11B1L, MTERF4, PTS, S1PR4, HJURP, HMMR, BOLA2, DNASE1L1, OSGEP,TMBIM4, BTNL3, CHRM3, FBXO15, KLK8, ASPN, STYK1 and SRSF6; or b. SYT11,PARM1, ROBO2, CD48, FCRL1 and MCL1; or c. PLCL2, KCNA3, TNFRSF21,CYP2U1, TRAM2 and RAPGEF5; or d. TSTD1, DNAJC12, TRAF3IP3, OPTN, DOCK10,PYHINI, CD48, P4HA2, PLCL2, AOX1, CDK6, GATM, GLUL, PAPSS1, MCL1 andGATM, are upregulated as compared to a reference value.
 36. (canceled)37. The method of claim 34, wherein if a BCL-2 inhibitor resistancesignature is detected the method further comprises administering atreatment to the subject according to claim
 1. 38. A method ofidentifying a signature gene, a gene signature, or other genetic elementassociated with a BCL-2 family function, activity or phenotypecomprising: a) contacting a cell or population of cells with an agentthat inhibits an anti-apoptotic BCL-2 family protein or a gene thatencodes the protein; and b) identifying one or more gene loci whoseactivity is modulated by step (a); thereby identifying a signature gene,a gene signature, or other genetic element associated with a BCL-2family function.
 39. The method of claim 38, wherein the cell orpopulation of cells comprises a Cas protein or nucleic acid encoding theCas protein and one or more guides or nucleic acids encoding the one ormore guides, wherein the guide(s) target one or more nucleic acid(s) inthe cell or population of cells, whereby one or more nucleic acid(s) inthe cell or population of cells is modified, whereby the viability of acell or population of cells comprising the one or more modified nucleicacid(s) is modulated; and/or wherein the cell or population of cellscomprises nucleic acids modified by a CRISPR-Cas system comprising a Casprotein and one or more guides; and/or wherein the viability of the cellor cell population comprising the one or more modified nucleic acid(s)is correlated with representation of one or more of the one or moreguides; and/or wherein the cell or population of cells comprises one ormore gene knock-outs; and/or wherein the CRISPR-Cas system comprises aCas9; and/or wherein the BCL-2 family protein is BCL-2.
 40. (canceled)41. (canceled)
 42. (canceled)
 43. (canceled)
 44. (canceled)
 45. A kitcomprising reagents to detect at least one gene or gene productaccording to claim 34.